Skip Navigation
Skip to contents

Intest Res : Intestinal Research

IMPACT FACTOR

Author index

Page Path
HOME > Browse articles > Author index
Search
Archana George 1 Article
Inflammatory bowel diseases
Quantitative histology-based classification system for assessment of the intestinal mucosal histological changes in patients with celiac disease
Prasenjit Das, Gaurav PS Gahlot, Alka Singh, Vandana Baloda, Ramakant Rawat, Anil K Verma, Gaurav Khanna, Maitrayee Roy, Archana George, Ashok Singh, Aasma Nalwa, Prashant Ramteke, Rajni Yadav, Vineet Ahuja, Vishnubhatla Sreenivas, Siddhartha Datta Gupta, Govind K Makharia
Intest Res 2019;17(3):387-397.   Published online April 22, 2019
DOI: https://doi.org/10.5217/ir.2018.00167
AbstractAbstract PDFPubReaderePub
Background/Aims
The existing histological classifications for the interpretation of small intestinal biopsies are based on qualitative parameters with high intraobserver and interobserver variations. We have developed and propose a quantitative histological classification system for the assessment of intestinal mucosal biopsies.
Methods
We performed a computer-assisted quantitative histological assessment of digital images of duodenal biopsies from 137 controls and 124 patients with celiac disease (CeD) (derivation cohort). From the receiver-operating curve analysis, followed by multivariate and logistic regression analyses, we identified parameters for differentiating control biopsies from those of the patients with CeD. We repeated the quantitative histological analysis in a validation cohort (105 controls and 120 patients with CeD). On the basis of the results, we propose a quantitative histological classification system. The new classification was compared with the existing histological classifications for interobserver and intraobserver agreements by a group of qualified pathologists.
Results
Among the histological parameters, intraepithelial lymphocyte count of ≥25/100 epithelial cells, adjusted villous height fold change of ≤0.7, and crypt depth-to-villous height ratio of ≥0.5 showed good discriminative power between the mucosal biopsies from the patients with CeD and those from the controls, with 90.3% sensitivity, 93.5% specificity, and 96.2% area under the curve. Among the existing histological classifications, our quantitative histological classification showed the highest intraobserver (69.7%–85.03%) and interobserver (24.6%–71.5%) agreements.
Conclusions
Quantitative assessment increases the reliability of the histological assessment of mucosal biopsies in patients with CeD. Such a classification system may be used for clinical trials in patients with CeD. (Intest Res, Published online)

Citations

Citations to this article as recorded by  
  • Celiac Disease Deep Learning Image Classification Using Convolutional Neural Networks
    Joaquim Carreras
    Journal of Imaging.2024; 10(8): 200.     CrossRef
  • CD, or not CD, that is the question: a digital interobserver agreement study in coeliac disease
    James Denholm, Benjamin A Schreiber, Florian Jaeckle, Mike N Wicks, Emyr W Benbow, Tim S Bracey, James Y H Chan, Lorant Farkas, Eve Fryer, Kishore Gopalakrishnan, Caroline A Hughes, Kathryn J Kirkwood, Gerald Langman, Betania Mahler-Araujo, Raymond F T Mc
    BMJ Open Gastroenterology.2024; 11(1): e001252.     CrossRef
  • Role of Serology, Dietary Assessment, and Fecal Gluten Immunogenic Peptides for Predicting Histologic Recovery in Children with Celiac Disease
    Keerthivasan Seetharaman, Sadhna Bhasin Lal, Kaushal Kishor Prasad, Yashwant Kumar, Alka Bhatia, Sunita Malhotra
    Digestive Diseases and Sciences.2023; 68(2): 529.     CrossRef
  • Usefulness of a double immunofluorescence technique for detection of intestinal tTG-IgA deposits in diabetic and non-diabetic children with celiac disease
    Raghav Lal, Ranjeet Bhardwaj, Ranjana Walker Minz, Kaushal Kishore Prasad, Sadhna Lal, Devi Dayal, Yashwant Kumar
    Pediatrics & Neonatology.2023; 64(4): 388.     CrossRef
  • The global burden of coeliac disease: opportunities and challenges
    Govind K. Makharia, Prashant Singh, Carlo Catassi, David S. Sanders, Daniel Leffler, Raja Affendi Raja Ali, Julio C. Bai
    Nature Reviews Gastroenterology & Hepatology.2022; 19(5): 313.     CrossRef
  • Gluten Induces Subtle Histological Changes in Duodenal Mucosa of Patients with Non-Coeliac Gluten Sensitivity: A Multicentre Study
    Kamran Rostami, Arzu Ensari, Michael N. Marsh, Amitabh Srivastava, Vincenzo Villanacci, Antonio Carroccio, Hamid Asadzadeh Aghdaei, Julio C. Bai, Gabrio Bassotti, Gabriel Becheanu, Phoenix Bell, Camillo Di Bella, Anna Maria Bozzola, Moris Cadei, Giovanni
    Nutrients.2022; 14(12): 2487.     CrossRef
  • The Role of Nerve Fibers in the Tumor Immune Microenvironment of Solid Tumors
    Sharia Hernandez, Alejandra G. Serrano, Luisa M. Solis Soto
    Advanced Biology.2022;[Epub]     CrossRef
  • Case Report: Morphologic and Functional Characteristics of Intestinal Mucosa in a Child With Short Bowel Syndrome After Treatment With Teduglutide: Evidence in Favor of GLP-2 Analog Safety
    Enrico Costantino Falco, Antonella Lezo, Pierluigi Calvo, Caterina Rigazio, Anna Opramolla, Ludovica Verdun, Giovanna Cenacchi, Marianna Pellegrini, Marco Spada, Gabriella Canavese
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Quantitative histology as a diagnostic tool for celiac disease in children and adolescents
    Mateus M. Vargas, Ricardo Artigiani Neto, Vera L. Sdepanian
    Annals of Diagnostic Pathology.2022; 61: 152031.     CrossRef
  • Best practices of handling, processing, and interpretation of small intestinal biopsies for the diagnosis and management of celiac disease: A joint consensus of Indian association of pathologists and microbiologists and Indian society of gastroenterology
    Prasenjit Das, Kim Vaiphei, AnjaliD Amarapurkar, Puja Sakhuja, Ritambhra Nada, RoopaRachel Paulose, Rachana Chaturvedi, Anuradha Sekaran, Usha Kini, Archana Rastogi, Niraj Kumari, Anna Pulimood, Mala Banerjee, Prateek Kinra, Lavleen Singh, AmarenderSingh
    Indian Journal of Pathology and Microbiology.2021; 64(5): 8.     CrossRef
  • Artificial intelligence in small intestinal diseases: Application and prospects
    Yu Yang, Yu-Xuan Li, Ren-Qi Yao, Xiao-Hui Du, Chao Ren
    World Journal of Gastroenterology.2021; 27(25): 3734.     CrossRef
  • Opportunities and challenges in the management of celiac disease in Asia
    Ashish Agarwal, Ashish Chauhan, Vineet Ahuja, Govind K Makharia
    JGH Open.2020; 4(5): 795.     CrossRef
  • Digital histology in celiac disease: A practice changer
    Daniel Vasile Balaban, Mariana Jinga
    Artificial Intelligence in Gastroenterology.2020; 1(1): 1.     CrossRef
  • Digital histology in celiac disease: A practice changer
    Daniel Vasile Balaban, Mariana Jinga
    Artificial Intelligence in Gastroenterology.2020; 1(1): 1.     CrossRef
  • 7,729 View
  • 181 Download
  • 13 Web of Science
  • 14 Crossref
Close layer

Intest Res : Intestinal Research
Close layer
TOP