Skip Navigation
Skip to contents

Intest Res : Intestinal Research

IMPACT FACTOR

Author index

Page Path
HOME > Browse articles > Author index
Search
Brijnandan Gupta 1 Article
Colorectal neoplasia
Topographic, histological and molecular study of aberrant crypt foci identified in human colon in different clinical groups
Shouriyo Ghosh, Brijnandan Gupta, Pavan Verma, Sreenivas Vishnubathla, Sujoy Pal, Nihar R Dash, Siddhartha Datta Gupta, Prasenjit Das
Intest Res 2018;16(1):116-125.   Published online January 18, 2018
DOI: https://doi.org/10.5217/ir.2018.16.1.116
AbstractAbstract PDFPubReaderePub
<b>Background/Aims</b><br/>

Aberrant crypt foci (ACF) are early microscopic lesions of the colonic mucosa, which can be detected by magnified chromoendoscopy. Herein, we have investigated whether ACF identified in different clinical groups can be differentiated based on their characteristics.

Methods

Macroscopically unremarkable mucosal flaps were collected from 270 fresh colectomies and divided into 3 clinical groups: colorectal carcinoma (group A), disease controls having known pre-neoplastic potential (group Bc), and disease controls without risk of carcinoma development (group Bn). Topographic and histologic analysis, immunohistochemistry, and molecular studies (high-resolution melt curve analysis, real-time polymerase chain reaction, and Sanger sequencing) were conducted for certain neoplasia-associated markers.

Results

ACF were seen in 107 cases, out of which 72 were left colonic ACF and 35 right colonic ACF (67.2% vs. 32.7%, P=0.02). The overall density of left colonic ACF was 0.97/cm, which was greater than the right colonic ACF density of 0.81/cm. Hypercrinia was present in 41 out of 72 left colonic ACF and in 14 out of 35 right colonic ACF (P=0.01). Immunohistochemical expression of p53 was also greater in left colonic ACF than in right colonic ACF (60.5% vs. 38.2%, P=0.03). However, ACF identified among the 3 clinical groups did not show any distinguishing topographic, histological, or genetic changes.

Conclusions

Left colonic ACF appear to be high-risk based on their morphological and prototypic tumor marker signature. ACF identified in different clinical groups do not show significant genotypic or topographic differences. Further detailed genetic studies are required to elucidate them further.

Citations

Citations to this article as recorded by  
  • Methylation study of tumor suppressor genes in human aberrant crypt foci, colorectal carcinomas, and normal colon
    Jayati Sarangi, Prasenjit Das, Aijaz Ahmad, Mohamed Sulaiman, Shouriyo Ghosh, Brijnandan Gupta, Rajesh Panwar, Sujoy Pal, Rajni Yadav, Vineet Ahuja, Sudip Sen, Asish D. Upadhyay, Nihar R. Dash, Atul Sharma, Siddhartha D. Gupta
    Journal of Cancer Research and Therapeutics.2024; 20(1): 268.     CrossRef
  • 7,314 View
  • 68 Download
  • 1 Web of Science
  • 1 Crossref
Close layer

Intest Res : Intestinal Research
Close layer
TOP