Intestinal Research

Bruno Geloneze

1 Article

Changes in serum levels of lipopolysaccharides and CD26 in patients with Crohn's disease: Daniéla Oliveira Magro, Paulo Gustavo Kotze, Carlos Augusto Real Martinez, Michel Gardere Camargo, Dioze Guadagnini, Antonio Ramos Calixto, Ana Carolina Junqueira Vasques, Maria de Lourdes Setsuko Ayrizono, Bruno Geloneze, José Carlos Pareja, Mario José Saad, Claudio Saddy Rodrigues Coy; Intest Res 2017;15(3):352-357. Published online June 12, 2017; DOI: https://doi.org/10.5217/ir.2017.15.3.352

<b>Background/Aims</b><br/>

Lipopolysaccharide (LPS) is a molecule formed by lipids and polysaccharides and is the major cell wall component of gram-negative bacteria. High LPS levels are known to block CD26 expression by activating Toll-like receptor 4. The aim of this study was to correlate the serum levels of LPS and CD26 in Crohn's disease (CD) patients with serum levels of C-reactive protein (CRP), interleukins, CD activity index, and tumor necrosis factor-α (TNF-α).

Methods

Serum samples were collected from 27 individuals (10 with active CD, 10 with inactive CD, and 7 controls) and the levels of LPS, CD26, TNF-α, interleukin-1β (IL-1β), IL-6, IL-17, and CRP were determined by enzyme-linked immunosorbent assay. The levels of LPS and CD26 were then tested for correlation with TNF-α, IL-1β, IL-6, IL-17, and CRP.

Results

Serum levels of LPS were significantly elevated in the active CD group (P=0.003). Levels of IL-1β (P=0.002), IL-6 (P=0.003), and IL-17 (P<0.001) were lower in the CD groups. Serum TNF-α levels were increased in the active CD group. The CRP levels were elevated in the CD groups when compared to controls (P<0.001). The CD26 levels were lower in the CD groups than in the control group (P<0.001). Among the variables analyzed, there was a correlation between LPS and CRP (r=−0.53, P=0.016) in the CD groups.

Conclusions

Individuals with CD exhibited higher serum levels of LPS varying from a 2- to 6-fold increase depending on disease activity, when compared with healthy controls. CD26 levels were lower in the CD groups. Both LPS and CD26 correlated with disease severity and serve as potential CD biomarkers.

Citations

Citations to this article as recorded by

ATHEROSCLEROTIC CARDIOVASCULAR COMPLICATIONS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE
Ondřej Kučerka, Martin Malý, Petra Mináriková, Jan M. Horáček
Military Medical Science Letters.2024;[Epub] CrossRef
Revolutionizing Treatment Strategies for Autoimmune and Inflammatory Disorders: The Impact of Dipeptidyl-Peptidase 4 Inhibitors
Kashif Rahim, Muhammad Shan, Ihtisham Ul Haq, Muhammad Nawaz, Sajida Maryam, Mansour Alturki, Abdulaziz Al Khzem, Kamel Metwally, Simona Cavalu, Saleh Alqifari, Galal Yahya
Journal of Inflammation Research.2024; Volume 17: 1897. CrossRef
Interaction between diet and genetics in patients with inflammatory bowel disease
Daniéla Oliveira Magro, Ligia Yukie Sassaki, Júlio Maria Fonseca Chebli
World Journal of Gastroenterology.2024; 30(12): 1644. CrossRef
Quantitative urinary proteome analysis reveals potential biomarkers for disease activity of Behcet’s disease uveitis
Weiwei Qin, Anyi Liang, Xiaoxu Han, Meifen Zhang, Youhe Gao, Chan Zhao
BMC Ophthalmology.2024;[Epub] CrossRef
Dietary fat induced chylomicron-mediated LPS translocation in a bicameral Caco-2cell model
Monic M. M. Tomassen, Coen Govers, A. Paul Vos, Nicole J. W. de Wit
Lipids in Health and Disease.2023;[Epub] CrossRef
Endothelial Glycocalyx Preservation—Impact of Nutrition and Lifestyle
Paula Franceković, Lasse Gliemann
Nutrients.2023; 15(11): 2573. CrossRef
Toll-like Receptors and Cytokine Modulation by Goat Milk Extracellular Vesicles in a Model of Intestinal Inflammation
Chiara Grazia De Ciucis, Floriana Fruscione, Livia De Paolis, Samanta Mecocci, Susanna Zinellu, Lisa Guardone, Giulia Franzoni, Katia Cappelli, Elisabetta Razzuoli
International Journal of Molecular Sciences.2023; 24(13): 11096. CrossRef
Longitudinal flux balance analyses of a patient with episodic colonic inflammation reveals microbiome metabolic dynamics
Arianna Basile, Almut Heinken, Johannes Hertel, Larry Smarr, Weizhong Li, Laura Treu, Giorgio Valle, Stefano Campanaro, Ines Thiele
Gut Microbes.2023;[Epub] CrossRef
Hyperimmune bovine colostrum containing lipopolysaccharide antibodies (IMM124-E) has a nondetrimental effect on gut microbial communities in unchallenged mice
Rachele Gore, Mitra Mohsenipour, Jennifer L. Wood, Gayathri K. Balasuriya, Elisa L. Hill-Yardin, Ashley E. Franks, Manuela Raffatellu
Infection and Immunity.2023;[Epub] CrossRef
MEFV and NLRP3 Inflammasome Expression Is Attributed to Immature Macrophages and Correlates with Serum Inflammatory Proteins in Crohn´s Disease Patients
Frida Gorreja, Charles Caër, Stephen T. A. Rush, Sophia K. Forsskål, Anetta Härtlova, Maria K. Magnusson, Elinor Bexe Lindskog, Lars G. Börjesson, Mattias Block, Mary Jo Wick
Inflammation.2022; 45(4): 1631. CrossRef
Emerging Role of Dipeptidyl Peptidase-4 in Autoimmune Disease
Jie Huang, Xinxin Liu, Yingying Wei, Xinlu Li, Shupei Gao, Lingli Dong, Xiaoquan Rao, Jixin Zhong
Frontiers in Immunology.2022;[Epub] CrossRef
Genetic Deletion of LRP5 and LRP6 in Macrophages Exacerbates Colitis-Associated Systemic Inflammation and Kidney Injury in Response to Intestinal Commensal Microbiota
Indumathi Manoharan, Daniel Swafford, Arulkumaran Shanmugam, Nikhil Patel, Puttur D. Prasad, Riyaz Mohamed, Qingqing Wei, Zheng Dong, Muthusamy Thangaraju, Santhakumar Manicassamy
The Journal of Immunology.2022; 209(2): 368. CrossRef
The Role of Dipeptidyl Peptidase 4 as a Therapeutic Target and Serum Biomarker in Inflammatory Bowel Disease: A Systematic Review
Francisco Jorge Melo, Pedro Pinto-Lopes, Maria Manuela Estevinho, Fernando Magro
Inflammatory Bowel Diseases.2021; 27(7): 1153. CrossRef
Effects of Anthocyanin on Intestinal Health: A Systematic Review
Thaísa Agrizzi Verediano, Hércia Stampini Duarte Martino, Maria Cristina Dias Paes, Elad Tako
Nutrients.2021; 13(4): 1331. CrossRef
Anti-inflammatory activity of Jasminum grandiflorum L. subsp. floribundum (Oleaceae) in inflammatory bowel disease and arthritis models
Riham A. El-Shiekh, Dorria Hussein, Attia H. Atta, Samar M. Mounier, Mohamed R. Mousa, Essam Abdel-Sattar
Biomedicine & Pharmacotherapy.2021; 140: 111770. CrossRef
Thromboembolic and atherosclerotic cardiovascular events in inflammatory bowel disease: epidemiology, pathogenesis and clinical management
Jasmijn A. M. Sleutjes, Jeanine E. Roeters van Lennep, C. Janneke van der Woude, Annemarie C. de Vries
Therapeutic Advances in Gastroenterology.2021;[Epub] CrossRef
Phase angle through electrical bioimpedance as a predictor of cellularity in inflammatory bowel disease
Sabrina A Fernandes, Carina Rossoni, Vivian W Koch, Marcello Imbrizi, Rosana Evangelista-Poderoso, Letícia Pereira Pinto, Daniéla Oliveira Magro
Artificial Intelligence in Gastroenterology.2021; 2(4): 111. CrossRef
Correlation between Antibodies to Bacterial Lipopolysaccharides and Barrier Proteins in Sera Positive for ASCA and ANCA
Aristo Vojdani, Elroy Vojdani, Martha Herbert, Datis Kharrazian
International Journal of Molecular Sciences.2020; 21(4): 1381. CrossRef
CD26/DPP4 - a potential biomarker and target for cancer therapy
Njanja Enz, Gwendolyn Vliegen, Ingrid De Meester, Wolfgang Jungraithmayr
Pharmacology & Therapeutics.2019; 198: 135. CrossRef
Is there a possible correlation between antibodies against lipopolysaccharide, intestinal and blood-brain barrier proteins in IBD subjects?
Aristo Vojdani
Autoimmunity Reviews.2019; 18(6): 639. CrossRef
CD26 in autoimmune diseases: The other side of “moonlight protein”
Yunjuan Zhao
International Immunopharmacology.2019; 75: 105757. CrossRef
Remission in Crohn’s disease is accompanied by alterations in the gut microbiota and mucins production
Daniéla Oliveira Magro, Andrey Santos, Dioze Guadagnini, Flavia Moreira de Godoy, Sylvia Helena Monteiro Silva, Wilson José Fernandes Lemos, Nicola Vitulo, Sandra Torriani, Lilian Vital Pinheiro, Carlos Augusto Real Martinez, Mario José Abdalla Saad, Clau
Scientific Reports.2019;[Epub] CrossRef
Dipeptidyl Peptidase 4 Inhibitors and Risk of Inflammatory Bowel Disease: Real-world Evidence in U.S. Adults
Tiansheng Wang, Jeff Y. Yang, John B. Buse, Virginia Pate, Huilin Tang, Edward L. Barnes, Robert S. Sandler, Til Stürmer
Diabetes Care.2019; 42(11): 2065. CrossRef
Emerging concepts in non-invasive monitoring of Crohn’s disease
Wojciech Marlicz, Karolina Skonieczna-Żydecka, Konstantinos John Dabos, Igor Łoniewski, Anastasios Koulaouzidis
Therapeutic Advances in Gastroenterology.2018;[Epub] CrossRef
VISCERAL FAT IS INCREASED IN INDIVIDUALS WITH CROHN’S DISEASE: A COMPARATIVE ANALYSIS WITH HEALTHY CONTROLS
Daniéla Oliveira MAGRO, Maria Rita Lazzarini BARRETO, Everton CAZZO, Michel Gardere CAMARGO, Paulo Gustavo KOTZE, Claudio Saddy Rodrigues COY
Arquivos de Gastroenterologia.2018; 55(2): 142. CrossRef

6,256 View
54 Download
24 Web of Science
25 Crossref

Author index