- Infection
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An overview of the gut side of the SARS-CoV-2 infection
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Bruna Barbosa da Luz, Natalia Mulinari Turin de Oliveira, Isabella Wzorek França dos Santos, Luana Zampieron Paza, Lara Luisa Valerio de Mello Braga, Fernanda da Silva Platner, Maria Fernanda de Paula Werner, Elizabeth Soares Fernandes, Daniele Maria-Ferreira
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Intest Res 2021;19(4):379-385. Published online November 6, 2020
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DOI: https://doi.org/10.5217/ir.2020.00087
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Abstract
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- In late 2019, an outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initiated in Wuhan, Hubei province, China. The major clinical symptoms described for coronavirus disease (COVID-19) include respiratory distress and pneumonia in severe cases, and some patients may experience gastrointestinal impairments. In accordance, viral RNA or live infectious virus have been detected in feces of patients with COVID-19. Binding of SARS-CoV-2 to the angiotensin‐converting enzyme 2 (ACE2) is a vital pathway for the virus entry into human cells, including those of the respiratory mucosa, esophageal epithelium as well as the absorptive enterocytes from ileum and colon. The interaction between SARS-CoV-2 and ACE2 receptor may decrease the receptor expression and disrupt the function of B0AT1 transporter influencing the diarrhea observed in COVID-19 patients. In this context, a fecal-oral transmission route has been considered and points out a role for the digestive tract in disease transmission and severity. Here, in order to further understand the impact of COVID-19 in human physiology, the cellular and molecular mechanisms of SARS-CoV-2 infection and disease severity are discussed in the context of gastrointestinal disturbances.
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Citations
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- COVID‐19 in a common woolly monkey (Lagothrix lagothricha): First evidence of fatal outcome in a nonhuman primate after natural SARS‐CoV‐2 infection
Eduardo A. Diaz, Carolina Sáenz, Francisco Cabrera, Javier Rodríguez, Mateo Carvajal, Verónica Barragán American Journal of Primatology.2024;[Epub] CrossRef - The COVID‐19 pandemic as a modifier of DGBI symptom severity: A systematic review and meta‐analysis
Dmitrii Kulin, Ayesha Shah, Thomas Fairlie, Reuben K. Wong, Xiucai Fang, Uday C. Ghoshal, Purna C. Kashyap, Agata Mulak, Yeong Yeh Lee, Nicholas J. Talley, Natasha Koloski, Michael P. Jones, Gerald J. Holtmann Neurogastroenterology & Motility.2024;[Epub] CrossRef - Disorders of gut-brain interaction in post-acute COVID-19 syndrome
Rithvik Golla, Sudheer Kumar Vuyyuru, Bhaskar Kante, Saurabh Kedia, Vineet Ahuja Postgraduate Medical Journal.2023; 99(1174): 834. CrossRef - Long-term Gastrointestinal Sequelae Following COVID-19: A Prospective Follow-up Cohort Study
Rithvik Golla, Sudheer Vuyyuru, Bhaskar Kante, Peeyush Kumar, David Mathew Thomas, Govind Makharia, Saurabh Kedia, Vineet Ahuja Clinical Gastroenterology and Hepatology.2023; 21(3): 789. CrossRef - Impacts of COVID-19 in Breast Cancer: From Molecular Mechanism to
the Treatment Approach
Maria Carolina Stipp, Claudia Rita Corso, Alexandra Acco Current Pharmaceutical Biotechnology.2023; 24(2): 238. CrossRef - Vaccination strategies for Korean patients with inflammatory bowel disease
Yoo Jin Lee, Eun Soo Kim The Korean Journal of Internal Medicine.2022; 37(5): 920. CrossRef - Korean Association for the Study of Intestinal Diseases guidance for clinical practice of adult inflammatory bowel disease during the coronavirus disease 2019 pandemic: expert consensus statements
Yong Eun Park, Yoo Jin Lee, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seong-Eun Kim, Seung-Jae Myung Intestinal Research.2022; 20(4): 431. CrossRef - Diarrhea Is a Hallmark of Inflammation in Pediatric COVID-19
Marco Poeta, Francesco Nunziata, Margherita Del Bene, Francesca Morlino, Alessia Salatto, Sara Maria Scarano, Valentina Cioffi, Michele Amitrano, Eugenia Bruzzese, Alfredo Guarino, Andrea Lo Vecchio Viruses.2022; 14(12): 2723. CrossRef - Shared inflammatory pathways and therapeutic strategies in COVID-19 and cancer immunotherapy
Lorenzo Iovino, Laurel A Thur, Sacha Gnjatic, Aude Chapuis, Filippo Milano, Joshua A Hill Journal for ImmunoTherapy of Cancer.2021; 9(5): e002392. CrossRef - KASID Guidance for Clinical Practice Management of Adult Inflammatory Bowel Disease during the COVID-19 Pandemic: Expert Consensus Statement
Yong Eun Park, Yoo Jin Lee, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seong-Eun Kim, Seung-Jae Myung The Korean Journal of Gastroenterology.2021; 78(2): 105. CrossRef - Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases
Baibaswata Nayak, Geetanjali Lal, Sonu Kumar, Chandan J. Das, Anoop Saraya, Shalimar Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef - Diosmectite inhibits the interaction between SARS-CoV-2 and human enterocytes by trapping viral particles, thereby preventing NF-kappaB activation and CXCL10 secretion
Marco Poeta, Valentina Cioffi, Vittoria Buccigrossi, Merlin Nanayakkara, Melissa Baggieri, Roberto Peltrini, Angela Amoresano, Fabio Magurano, Alfredo Guarino Scientific Reports.2021;[Epub] CrossRef - Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention
Nikola Gligorijevic, Mirjana Radomirovic, Olgica Nedic, Marija Stojadinovic, Urmila Khulal, Dragana Stanic-Vucinic, Tanja Cirkovic Velickovic International Journal of Molecular Sciences.2021; 22(22): 12385. CrossRef - Clinical Course of COVID-19 in Patients with Inflammatory Bowel Disease in Korea: a KASID Multicenter Study
Jin Wook Lee, Eun Mi Song, Sung-Ae Jung, Sung Hoon Jung, Kwang Woo Kim, Seong-Joon Koh, Hyun Jung Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park Journal of Korean Medical Science.2021;[Epub] CrossRef
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