- Miscellaneous
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Hydroxyurea associated ileocecal valve ulcer: evidence for causality
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Thevaraajan Jayaraman, Ruveena Bhavani Rajaram, Gin Gin Gan, Ida Hilmi
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Intest Res 2021;19(4):468-471. Published online December 1, 2020
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DOI: https://doi.org/10.5217/ir.2020.00099
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 Abstract
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- Hydroxyurea is an antimetabolite drug that is commonly used in many hematological disorders. Ulcer formation in the gastrointestinal tract is a rare phenomenon associated with this drug. We report a case of a 73-year-old woman who was found to have an isolated ileocecal valve ulcer while on hydroxyurea 1 g daily for essential thrombocythemia. A comprehensive evaluation ruled out all other causes. The cytoreductive therapy was switched to anagrelide and the endoscopic evaluation 6 months later showed complete healing of the ulcer. However, the hydroxyurea was resumed due to increasing platelet counts and intolerance to dose increments of the anagrelide. Subsequently, the patient was found to have a recurrence of the ulcer. Apart from oral ulcers, there have also been reports of ulcers involving the small bowel and the colon associated with the use of hydroxyurea. The pathophysiology of the non-oral gastrointestinal ulceration in relation to this drug is unclear. Withdrawal of the drug typically leads to complete resolution. Increasing awareness of the rare association between the use of hydroxyurea and nonoral gastrointestinal ulcers is essential for early detection to prevent related complications.
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Citations
Citations to this article as recorded by  - Hydroxyurea-related ileocecal region ulcers as a rare complication: A case report
Wen-Jin Yuan, Yi-Juan Zheng, Bing-Rong Zhang, Yi-Jie Lin, You Li, Yan-Yan Qiu, Xue-Ping Yu
World Journal of Clinical Cases.2025;[Epub] CrossRef - Repairing of recurrent leg ulcer induced by hydroxyurea with posterior tibial artery perforator propeller flap: Case report
Zheng-Dong Wan, Wu-Zhou Li
International Journal of Surgery Case Reports.2024; 114: 109049. CrossRef - Esophageal and Ileal Ulcers Caused by Hydroxycarbamide: A Case Report and Literature Review
Takumi Inaba, Yu Yamamoto, Kaho Hirayama, Takuma Kobayashi, Naoto Izumi, Hirotsugu Sakamoto, Shuji Hatakeyama, Masami Matsumura
Internal Medicine.2024;[Epub] CrossRef
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