-
Response to Biofeedback Therapy for Patients with Rectal Hyposensitivity
-
Kee Wook Jung, Seung-Jae Myung, Jeong-Sik Byeon, In Ja Yoon, Jung Eun Ko, So Young Seo, Soon Man Yoon, Mi Young Do, Do Hoon Kim, Benjamin Kim, Seunghyun Kwon, Byong Duk Ye, Hwoon-Yong Jung, Suk-Kyun Yang, Jin-Ho Kim
-
Intest Res 2008;6(1):56-69. Published online June 30, 2008
-
-
-
 Abstract
 PDF
- Background/Aims
Rectal hyposensitivity (RH) has been treated with conventional biofeedback therapy (BFT), whereas the effectiveness and long term results of this therapy are not known. We aimed to investigate the effectiveness of BFT for patients with RH by conducting a retrospective review of prospectively collected data. Methods: From June 2004 to March 2007, we enrolled those RH patients who underwent BFT. BFT was performed two or three times every week. Six months after BFT, the clinical response was evaluated by subjective and objective parameters. Results: A total of 82 RH patients underwent BFT. Fifty three patients finished BFT and the other 29 patients dropped out during BFT. Thirty six patients (67.9%) showed responsiveness (R) to BFT and 17 (31.5%) showed non-responsiveness (NR). The characteristics between the two groups showed no difference, except for the "desire to defecate" volume (116.1±25.2 in the R group vs. 140.0±43.9 in the NR group, p value ＜0.05) and the rectoanal inhibitory reflex (RAIR) (15.6±0.5 in the R group R vs. 27.6±18.2 in the NR group, p value ＜0.05). The R group showed a shorter colon transit time compared to NR group. At six months after BFT, a total of 20 patients were interviewed; 15 patients answered that they still had responsiveness (75%). Conclusions: The patients with RH showed a similar BFT response to that of the constipated patients. However, the patients with a more hyposensitive rectum and a longer colonic transit showed NR to BFT, suggesting RH is an important factor in BFT responsiveness. (Intest Res 2008;6:56-69)
-
Clinical Manifestations and Course of Intestinal Behet's Disease: An Analysis in Relation to Disease Subtypes
-
Dae-Kyoum Kim, Suk-Kyun Yang, Jeong-Sik Byeon, Seung-Jae Myung, Ji-Yun Jo, Kee Don Choi, Gin Hyug Lee, Hwoon-Yong Jung, Weon-Seon Hong, Jin-Ho Kim, Young Il Min, Chang Sik Yu
-
Intest Res 2005;3(1):48-54. Published online June 30, 2005
-
-
-
Abstract
PDF
- Background/Aims
Intestinal Behet's disease (BD) is one of the main causes of morbidity and mortality of BD because it frequently results in serious complications such as perforation and bleeding. But clinical course of intestinal BD is not well-known. The aim of this study was to review clinical manifestations of intestinal BD, and to compare clinical findings of complete and incomplete types with those of suspected type. Methods: From June 1989 to January 2005, 87 patients who had colonoscopic evidence of intestinal BD and met the criteria proposed by BD Research Committee of Japan were enrolled in this study. Clinical manifestations were collected by retrospective review of medical records. Results: Mean age at diagnosis was 38.4 years (14-66) and sex ratio was 2：1. Abdominal pain was the most frequent gastrointestinal symptom. A single, round ulcer localized at the ileocecal area was the most common colonoscopic finding. Cumulative incidence of first and second operation in 10 years was 30.9% and 38.2%, respectively. Clinical manifestations of suspected type were not different from those of complete and incomplete types. Conclusions: Long-term follow up and close observation is needed for patients with intestinal BD. Although suspected type does not meet the criteria proposed by International Study Group for BD, it should be considered as BD. (Intest Res 2005; 3:48-54)
-
The Influence of Inflammatory Bowel Disease and Its Treatment with 5-Aminosalicylic Acid on Pregnancy and Fetal Outcome
-
Ji Hun Choi, Hye Seung Yoo, Suk-Kyun Yang, Seung-Jae Myung, Yun Kyung Cho, Yun-Jung Lee, Jeong-Sik Byeon, Gin Hyug Lee, Hwoon-Yong Jung, Weon-Seon Hong, Jin-Ho Kim, Young Il Min
-
Intest Res 2004;2(1):26-30. Published online April 16, 2004
-
-
-
Abstract
PDF
- Background/Aims
5-Aminosalicylic acid (5-ASA) preparations are the first-line drugs in the treatment of inflammatory bowel disease (IBD). The aim of this study was to examine the influence of IBD and its treatment with 5-ASA on pregnancy and fetal outcome. Methods: A total of 56 patients (ulcerative colitis 41, Crohn's disease 15) experienced 84 pregnancies among 634 female patients with IBD between June 1989 and August 2003. The outcomes of 42 pregnancies exposed to 5-ASA during pregnancy were compared with those of 42 non-exposed pregnancies. Results: Pregnancy outcomes were not different between the exposed and non-exposed pregnancies in terms of live birth (85.7% vs 80.9%), abortion (11.9% vs 19.0%), stillbirth (2.4% vs 0%), preterm delivery (11.1% vs 5.9%), low birth weight (11.1% vs 8.8%), congenital malformation (2.8% vs 2.9%), and aggravation of disease during pregnancy (21.4% vs 16.7%). These figures appear to be similar to those of general population. Conclusions: Neither ulcerative colitis nor Crohn's disease has any significant impact on pregnancy outcome, and 5-ASA does not increase the risk of congenital malformation. (Intestinal Research 2004;2:26-30)
-
The Prevalence of Colorectal Neoplasms and the Role of Screening Colonoscopy in Asymptomatic Korean Adults
-
Hye-Sook Chang, Jae-Won Choe, Suk-Kyun Yang, Seung-Jae Myung, Hwoon-Yong Jung, Gin Hyug Lee, Weon-Seon Hong, Jin-Ho Kim, Young-Il Min
-
Intest Res 2003;1(2):179-185. Published online November 27, 2003
-
-
-
Abstract
PDF
- Background/Aims
Recent studies have reported the importance of screening colonoscopy for colorectal cancer. However, the prevalence of colorectal neoplasms in asymptomatic Korean population has not been determined until now. The purpose of this study was to evaluate the prevalence of colorectal neoplasms in asymptomatic Korean population and to assess the role of colonoscopy in colorectal cancer screening. Methods: We reviewed the endoscopic and pathologic reports of 3,325 patients who underwent colonoscopy at the Health Promotion Center, Asan Medical Center, from 1998 to 2002. Of them, 2,208 asymptomatic patients who underwent colonoscopy for the purpose of colorectal cancer screening were enrolled. Results: The mean age was 49.2 years and 70.8% were men. The overall prevalence of colorectal neoplasms was 18.6% and the prevalence among patients 50 years of age or older was 26.3%. The prevalence of neoplasms increased with age and was higher in the male. Patients with distal neoplasms were more likely to have proximal neoplasms than those without distal neoplasms. However, 69.2% of the patients with advanced proximal neolplasms had no synchronous distal neoplasms. Conclusions: The prevalence of colorectal neoplasms in asymptomatic average-risk Koreans seems to be lower than that in corresponding Westerns and shows a gender-difference. These results should be considered when establishing a guideline for colorectal cancer screening in Korea. Over half of the patients with advanced proximal neoplasms will not be detected if only those with distal neoplasms undergo colonoscopic screening. Therefore, colonoscopy may be useful as a screening test for colorectal cancer. (Intestinal Research 2003;2:179-185)
-
Familial Occurrence of Ulcerative Colitis in All 4 Family Members
-
Jeong-Sik Byeon, Suk-Kyun Yang, Yun Jung Lee, Jae Won Choe, Gin Hyug Lee, Seung-Jae Myung, Hwoon-Yong Jung, Weon-Seon Hong, Jin-Ho Kim, Young Il Min
-
Intest Res 2003;1(1):72-82. Published online May 27, 2003
-
-
-
Abstract
PDF
- The pathogenesis of ulcerative colitis is complicated and both the genetic and environmental factors contribute to its development. Familial occurrence is an example indicating that both the genetic and environmental factors play some parts in the development of ulcerative colitis because family members have similar genetic characteristics and have been exposed to similar environment. Familial ulcerative colitis is observed in about 10% to 20% of patients. Most such families contain only 2 affected members and families containing more than 2 affected members are relatively rare. We experienced a case of familial ulcerative colitis in which all 4 members (both spouses and their 2 sons) were affected. They had lived together for 29 years before all 4 members were affected. The first patient was diagnosed after 14 years of cohabitation and the rest were affected 13, 14, and 15 years after the first diagnosis. We report this case with a review of literature. (Intestinal Research 2003;1:72-77)
|
KASID
