Intestinal Research

Ja Young Jung

2 Articles

Do we need colonoscopy verification in patients with fundic gland polyp?: Hee Sook Lee, Younjeong Choi, Ja Young Jung, Young-Jun Sung, Dong Won Ahn, Ji Bong Jeong, Byeong Gwan Kim, Kook Lae Lee, Seong-Joon Koh, Ji Won Kim; Intest Res 2016;14(2):172-177. Published online April 27, 2016; DOI: https://doi.org/10.5217/ir.2016.14.2.172

Background/Aims

The aim of this study was to evaluate the prevalence of colorectal neoplasia in subjects with fundic gland polyps (FGPs) and the relationship between FGPs and colorectal neoplasia in Korea.

Methods

We analyzed 128 consecutive patients with FPGs who underwent colonoscopy between January 2009 and December 2013. For each case, age- (±5 years) and sex-matched controls were identified from among patients with hyperplastic polyps, gastric neoplasms, and healthy controls. Clinical characteristics were reviewed from medical records, colonoscopic findings, pathologic findings, and computed tomography images. The outcome was evaluated by comparison of advanced colonic neoplasia detection rates.

Results

Of the 128 patients, seven (5.1%) had colon cancers and seven (5.1%) had advanced adenomas. A case-control study revealed that the odds of detecting a colorectal cancer was 3.8 times greater in patients with FGPs than in the age- and sex-matched healthy controls (odds ratio [OR], 3.80; 95% confidence interval [CI], 1.09–13.24; P =0.04) and 4.1 times greater in patients with FGPs than in healthy controls over 50 years of age (OR, 4.10; 95% CI, 1.16–14.45; P =0.04). Among patients with FGPs over 50 years old, male sex (OR, 4.83; 95% CI, 1.23–18.94; P =0.02), and age (OR, 9.90; 95% CI, 1.21–81.08; P =0.03) were associated with an increased prevalence of advanced colorectal neoplasms.

Conclusions

The yield of colonoscopy in colorectal cancer patients with FGPs was substantially higher than that in average-risk subjects. Colonoscopy verification is warranted in patients with FGPs, especially in those 50 years of age or older.

Citations

Citations to this article as recorded by

Current Guidelines and Advances in the Management of Fundic Gland Polyps
Majed Ali, Lynn Srour, Mustapha Bitar, Karam Karam, Ihab I. El Hajj, Elias Fiani
Journal of Gastroenterology and Hepatology.2025; 40(6): 1374. CrossRef
Cold snare polypectomy for fundic gland polyps
Chi‐Hung Chen, Jen‐Chieh Huang, Jeng‐Shiann Shin
Advances in Digestive Medicine.2022; 9(1): 17. CrossRef
Clinical features of fundic gland polyps and their correlation with colorectal tumors
Xue-Mei Yang, Hong Xu
World Chinese Journal of Digestology.2020; 28(20): 1036. CrossRef
Parietalzellhypertrophie und Drüsenkörperzysten
M. Venerito, A. Canbay, M. Vieth
Der Gastroenterologe.2018; 13(2): 90. CrossRef

7,035 View
43 Download
4 Web of Science
4 Crossref

Circulating Ghrelin Levels and Obestatin/Ghrelin Ratio as a Marker of Activity in Ulcerative Colitis: Ja Young Jung, Ji Bong Jeong, Ji Won Kim, Su Hwan Kim, Seong-Joon Koh, Byeong Gwan Kim, Kook Lae Lee; Intest Res 2015;13(1):68-73. Published online January 29, 2015; DOI: https://doi.org/10.5217/ir.2015.13.1.68

Abstract PDF PubReader

Background/Aims

Ghrelin levels are known to increase in patients with ulcerative colitis (UC), but serum obestatin levels in UC patients are not well elucidated. The aim of this study was to examine the relationship between serum ghrelin and obestatin levels and disease activity in UC patients.

Methods

The serum ghrelin and obestatin levels were measured in 21 UC patients (12 with active disease and 9 in remission) using enzyme-linked immunosorbent assay. The relationship between the circulating levels of these 2 hormones and disease activity was analyzed. The colonic mucosal mRNA expression of ghrelin and obestatin was measured by quantitative reverse transcription polymerase chain reaction.

Results

The mean serum ghrelin values were significantly higher in patients with active disease than in patients with remission (1370.6±404.3 vs. 783.5±235.3 pg/mL, P=0.001). Colonic mucosal mRNA expression of ghrelin was also significantly higher in patients with active disease than in patients in remission (0.805±0.214 vs. 0.481±0.356, P=0.018). However, the mean serum obestatin levels and colonic mucosal mRNA expression of obestatin were not significantly different between both groups. The circulating obestatin/ghrelin ratio was significantly lower in patients with active UC than in patients in remission (0.32±0.08 vs. 0.58±0.20, P=0.001).

Conclusions

The serum ghrelin levels and the obestatin/ghrelin ratio were related to the activity of UC, but serum obestatin was not related to activity of UC. The ghrelin levels and the obestatin/ghrelin ratio could serve as activity markers in patients with UC.

Citations

Citations to this article as recorded by

Unveiling the Ghrelin and Obestatin Roles in Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis Assessing Their Pathogenic Implications and Biomarker Utility
Amirmohammad Khalaji, Nastaran Babajani, Zahra Amirsardari, Behrad Saeedian, Soheil Peiman, Nathan A Berger, Amir Hossein Behnoush
Inflammatory Bowel Diseases.2024; 30(4): 629. CrossRef
Effects of Spirulina supplementation in patients with ulcerative colitis: a double-blind, placebo-controlled randomized trial
Sajjad Moradi, Reza Bagheri, Parsa Amirian, Mahsa Zarpoosh, Neda Cheraghloo, Alexei Wong, Mehdi Zobeiri, Mohammad Hassan Entezari
BMC Complementary Medicine and Therapies.2024;[Epub] CrossRef
“Sibling” battle or harmony: crosstalk between nesfatin-1 and ghrelin
Xi Chen, Jing Dong, Qian Jiao, Xixun Du, Mingxia Bi, Hong Jiang
Cellular and Molecular Life Sciences.2022;[Epub] CrossRef
Role of the Ghrelin System in Colitis and Hepatitis as Risk Factors for Inflammatory-Related Cancers
Aldona Kasprzak, Agnieszka Adamek
International Journal of Molecular Sciences.2022; 23(19): 11188. CrossRef
Correlation between the tissue ghrelin presence, disease activity and laboratory parameters in ulcerative colitis patients; immunohistochemical study
Memduh Sahin, Kivilcim Eren Erdogan, Emine Tekingündüz, Gernot Zissel
PLOS ONE.2022; 17(11): e0276065. CrossRef
l-Glutamine and Physical Exercise Prevent Intestinal Inflammation and Oxidative Stress Without Improving Gastric Dysmotility in Rats with Ulcerative Colitis
Raisa de Oliveira Santos, Geovane da Silva Cardoso, Lara da Costa Lima, Mickael Laudrup de Sousa Cavalcante, Mariana Sousa Silva, Ana Karolina Martins Cavalcante, Juliana Soares Severo, Francisca Beatriz de Melo Sousa, Gabriella Pacheco, Even Herlany Pere
Inflammation.2021; 44(2): 617. CrossRef
Obestatin and Its Fragments: A New Approach to the Regulation of Body Weight under Normal and Pathological Conditions
A. V. Graf, E. E. Khirazova, M. V. Maslova, N. A. Sokolova
Moscow University Biological Sciences Bulletin.2020; 75(2): 50. CrossRef
Ghrelin and gastrointestinal wound healing. A new perspective for colorectal surgery
Humberto Fenner Lyra Junior, Igor Kunze Rodrigues, Leonardo de Lucca Schiavon, Armando José D`Acâmpora
Acta Cirurgica Brasileira.2018; 33(3): 282. CrossRef
TNF-α inhibits SCF, ghrelin, and substance P expressions through the NF-κB pathway activation in interstitial cells of Cajal
Keyu Ren, Chunming Yong, Hao Yuan, Bin Cao, Kun Zhao, Jin Wang
Brazilian Journal of Medical and Biological Research.2018;[Epub] CrossRef
Biochemical properties and biological actions of obestatin and its relevence in type 2 diabetes
Brian D. Green, David J. Grieve
Peptides.2018; 100: 249. CrossRef
Treatment with Obestatin—A Ghrelin Gene-Encoded Peptide—Reduces the Severity of Experimental Colitis Evoked by Trinitrobenzene Sulfonic Acid
Katarzyna Konarska, Jakub Cieszkowski, Zygmunt Warzecha, Piotr Ceranowicz, Anna Chmura, Beata Kuśnierz-Cabala, Krystyna Gałązka, Paweł Kowalczyk, Andrzej Miskiewicz, Thomas Jan Konturek, Michał Pędziwiatr, Artur Dembiński
International Journal of Molecular Sciences.2018; 19(6): 1643. CrossRef
Serum Adipocytokine Levels as Surrogate Markers for Disease Activity of Crohn’s Disease
Su Hwan Kim, Seung Hyeon Jang, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee, You Sun Kim, Dong Soo Han, Joo Sung Kim
The American Journal of the Medical Sciences.2017; 353(5): 439. CrossRef
Function of obestatin in the digestive system
Yue-Xian Xing, Liu Yang, Hong-Yu Kuang, Xin-Yuan Gao, Hao-Ling Liu
Nutrition.2017; 34: 21. CrossRef
NF-kappa B activation correlates with disease phenotype in Crohn’s disease
Yoo Min Han, Jaemoon Koh, Ji Won Kim, Changhyun Lee, Seong-Joon Koh, ByeongGwan Kim, Kook Lae Lee, Jong Pil Im, Joo Sung Kim, Gernot Sellge
PLOS ONE.2017; 12(7): e0182071. CrossRef
The obestatin/ghrelin ratio and ghrelin genetics in adult celiac patients before and after a gluten-free diet, in irritable bowel syndrome patients and healthy individuals
Francesco Russo, Guglielmina Chimienti, Michele Linsalata, Caterina Clemente, Antonella Orlando, Giuseppe Riezzo
European Journal of Gastroenterology & Hepatology.2017; 29(2): 160. CrossRef
Plasma ghrelin level and plasma ghrelin/obestatin ratio are related to intestinal metaplasia in elderly patients with functional dyspepsia
Su Hwan Kim, Ji Won Kim, Junsu Byun, Ji Bong Jeong, Byeong Gwan Kim, Kook Lae Lee, Zane B Andrews
PLOS ONE.2017; 12(4): e0175231. CrossRef
Plasma ghrelin and leptin in patients with inflammatory bowel disease and its association with nutritional status
Firas A. Ghomraoui, Sami T. Alotaibi, Meshal A. Alharthi, Saeed S. Asiri, Majid A. Almadi, Othman R. Alharbi, Nahla A. Azzam, Abdulrahman M. Aljebreen, Maria Saeed, Baraa Hajkhder, Waleed Saeed, Mohammad A. Alzoghaibi
Saudi Journal of Gastroenterology.2017; 23(3): 199. CrossRef
Obestatin as a key regulator of metabolism and cardiovascular function with emerging therapeutic potential for diabetes
Elaine Cowan, Kerry J Burch, Brian D Green, David J Grieve
British Journal of Pharmacology.2016; 173(14): 2165. CrossRef
Obestatin Accelerates the Healing of Acetic Acid‐Induced Colitis in Rats
Aleksandra Matuszyk, Piotr Ceranowicz, Zygmunt Warzecha, Jakub Cieszkowski, Joanna Bonior, Jolanta Jaworek, Beata Kuśnierz-Cabala, Peter Konturek, Tadeusz Ambroży, Artur Dembiński, Tanea T. Reed
Oxidative Medicine and Cellular Longevity.2016;[Epub] CrossRef
Ghrelin receptor modulates T helper cells during intestinal inflammation
M. Di Giovangiulio, N. Stakenborg, G. Bosmans, E. Meroni, G. Farro, P. J. Gomez‐Pinilla, I. Depoortere, G. E. Boeckxstaens, G. Matteoli
Neurogastroenterology & Motility.2015; 27(11): 1542. CrossRef

5,756 View
36 Download
21 Web of Science
20 Crossref

Author index