Intestinal Research

Ji Bong Jeong

8 Articles

Do we need colonoscopy verification in patients with fundic gland polyp?: Hee Sook Lee, Younjeong Choi, Ja Young Jung, Young-Jun Sung, Dong Won Ahn, Ji Bong Jeong, Byeong Gwan Kim, Kook Lae Lee, Seong-Joon Koh, Ji Won Kim; Intest Res 2016;14(2):172-177. Published online April 27, 2016; DOI: https://doi.org/10.5217/ir.2016.14.2.172

Background/Aims

The aim of this study was to evaluate the prevalence of colorectal neoplasia in subjects with fundic gland polyps (FGPs) and the relationship between FGPs and colorectal neoplasia in Korea.

Methods

We analyzed 128 consecutive patients with FPGs who underwent colonoscopy between January 2009 and December 2013. For each case, age- (±5 years) and sex-matched controls were identified from among patients with hyperplastic polyps, gastric neoplasms, and healthy controls. Clinical characteristics were reviewed from medical records, colonoscopic findings, pathologic findings, and computed tomography images. The outcome was evaluated by comparison of advanced colonic neoplasia detection rates.

Results

Of the 128 patients, seven (5.1%) had colon cancers and seven (5.1%) had advanced adenomas. A case-control study revealed that the odds of detecting a colorectal cancer was 3.8 times greater in patients with FGPs than in the age- and sex-matched healthy controls (odds ratio [OR], 3.80; 95% confidence interval [CI], 1.09–13.24; P =0.04) and 4.1 times greater in patients with FGPs than in healthy controls over 50 years of age (OR, 4.10; 95% CI, 1.16–14.45; P =0.04). Among patients with FGPs over 50 years old, male sex (OR, 4.83; 95% CI, 1.23–18.94; P =0.02), and age (OR, 9.90; 95% CI, 1.21–81.08; P =0.03) were associated with an increased prevalence of advanced colorectal neoplasms.

Conclusions

The yield of colonoscopy in colorectal cancer patients with FGPs was substantially higher than that in average-risk subjects. Colonoscopy verification is warranted in patients with FGPs, especially in those 50 years of age or older.

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Current Guidelines and Advances in the Management of Fundic Gland Polyps
Majed Ali, Lynn Srour, Mustapha Bitar, Karam Karam, Ihab I. El Hajj, Elias Fiani
Journal of Gastroenterology and Hepatology.2025; 40(6): 1374. CrossRef
Cold snare polypectomy for fundic gland polyps
Chi‐Hung Chen, Jen‐Chieh Huang, Jeng‐Shiann Shin
Advances in Digestive Medicine.2022; 9(1): 17. CrossRef
Clinical features of fundic gland polyps and their correlation with colorectal tumors
Xue-Mei Yang, Hong Xu
World Chinese Journal of Digestology.2020; 28(20): 1036. CrossRef
Parietalzellhypertrophie und Drüsenkörperzysten
M. Venerito, A. Canbay, M. Vieth
Der Gastroenterologe.2018; 13(2): 90. CrossRef

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Circulating Ghrelin Levels and Obestatin/Ghrelin Ratio as a Marker of Activity in Ulcerative Colitis: Ja Young Jung, Ji Bong Jeong, Ji Won Kim, Su Hwan Kim, Seong-Joon Koh, Byeong Gwan Kim, Kook Lae Lee; Intest Res 2015;13(1):68-73. Published online January 29, 2015; DOI: https://doi.org/10.5217/ir.2015.13.1.68

Abstract PDF PubReader

Background/Aims

Ghrelin levels are known to increase in patients with ulcerative colitis (UC), but serum obestatin levels in UC patients are not well elucidated. The aim of this study was to examine the relationship between serum ghrelin and obestatin levels and disease activity in UC patients.

Methods

The serum ghrelin and obestatin levels were measured in 21 UC patients (12 with active disease and 9 in remission) using enzyme-linked immunosorbent assay. The relationship between the circulating levels of these 2 hormones and disease activity was analyzed. The colonic mucosal mRNA expression of ghrelin and obestatin was measured by quantitative reverse transcription polymerase chain reaction.

Results

The mean serum ghrelin values were significantly higher in patients with active disease than in patients with remission (1370.6±404.3 vs. 783.5±235.3 pg/mL, P=0.001). Colonic mucosal mRNA expression of ghrelin was also significantly higher in patients with active disease than in patients in remission (0.805±0.214 vs. 0.481±0.356, P=0.018). However, the mean serum obestatin levels and colonic mucosal mRNA expression of obestatin were not significantly different between both groups. The circulating obestatin/ghrelin ratio was significantly lower in patients with active UC than in patients in remission (0.32±0.08 vs. 0.58±0.20, P=0.001).

Conclusions

The serum ghrelin levels and the obestatin/ghrelin ratio were related to the activity of UC, but serum obestatin was not related to activity of UC. The ghrelin levels and the obestatin/ghrelin ratio could serve as activity markers in patients with UC.

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Unveiling the Ghrelin and Obestatin Roles in Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis Assessing Their Pathogenic Implications and Biomarker Utility
Amirmohammad Khalaji, Nastaran Babajani, Zahra Amirsardari, Behrad Saeedian, Soheil Peiman, Nathan A Berger, Amir Hossein Behnoush
Inflammatory Bowel Diseases.2024; 30(4): 629. CrossRef
Effects of Spirulina supplementation in patients with ulcerative colitis: a double-blind, placebo-controlled randomized trial
Sajjad Moradi, Reza Bagheri, Parsa Amirian, Mahsa Zarpoosh, Neda Cheraghloo, Alexei Wong, Mehdi Zobeiri, Mohammad Hassan Entezari
BMC Complementary Medicine and Therapies.2024;[Epub] CrossRef
“Sibling” battle or harmony: crosstalk between nesfatin-1 and ghrelin
Xi Chen, Jing Dong, Qian Jiao, Xixun Du, Mingxia Bi, Hong Jiang
Cellular and Molecular Life Sciences.2022;[Epub] CrossRef
Role of the Ghrelin System in Colitis and Hepatitis as Risk Factors for Inflammatory-Related Cancers
Aldona Kasprzak, Agnieszka Adamek
International Journal of Molecular Sciences.2022; 23(19): 11188. CrossRef
Correlation between the tissue ghrelin presence, disease activity and laboratory parameters in ulcerative colitis patients; immunohistochemical study
Memduh Sahin, Kivilcim Eren Erdogan, Emine Tekingündüz, Gernot Zissel
PLOS ONE.2022; 17(11): e0276065. CrossRef
l-Glutamine and Physical Exercise Prevent Intestinal Inflammation and Oxidative Stress Without Improving Gastric Dysmotility in Rats with Ulcerative Colitis
Raisa de Oliveira Santos, Geovane da Silva Cardoso, Lara da Costa Lima, Mickael Laudrup de Sousa Cavalcante, Mariana Sousa Silva, Ana Karolina Martins Cavalcante, Juliana Soares Severo, Francisca Beatriz de Melo Sousa, Gabriella Pacheco, Even Herlany Pere
Inflammation.2021; 44(2): 617. CrossRef
Obestatin and Its Fragments: A New Approach to the Regulation of Body Weight under Normal and Pathological Conditions
A. V. Graf, E. E. Khirazova, M. V. Maslova, N. A. Sokolova
Moscow University Biological Sciences Bulletin.2020; 75(2): 50. CrossRef
Ghrelin and gastrointestinal wound healing. A new perspective for colorectal surgery
Humberto Fenner Lyra Junior, Igor Kunze Rodrigues, Leonardo de Lucca Schiavon, Armando José D`Acâmpora
Acta Cirurgica Brasileira.2018; 33(3): 282. CrossRef
TNF-α inhibits SCF, ghrelin, and substance P expressions through the NF-κB pathway activation in interstitial cells of Cajal
Keyu Ren, Chunming Yong, Hao Yuan, Bin Cao, Kun Zhao, Jin Wang
Brazilian Journal of Medical and Biological Research.2018;[Epub] CrossRef
Biochemical properties and biological actions of obestatin and its relevence in type 2 diabetes
Brian D. Green, David J. Grieve
Peptides.2018; 100: 249. CrossRef
Treatment with Obestatin—A Ghrelin Gene-Encoded Peptide—Reduces the Severity of Experimental Colitis Evoked by Trinitrobenzene Sulfonic Acid
Katarzyna Konarska, Jakub Cieszkowski, Zygmunt Warzecha, Piotr Ceranowicz, Anna Chmura, Beata Kuśnierz-Cabala, Krystyna Gałązka, Paweł Kowalczyk, Andrzej Miskiewicz, Thomas Jan Konturek, Michał Pędziwiatr, Artur Dembiński
International Journal of Molecular Sciences.2018; 19(6): 1643. CrossRef
Serum Adipocytokine Levels as Surrogate Markers for Disease Activity of Crohn’s Disease
Su Hwan Kim, Seung Hyeon Jang, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee, You Sun Kim, Dong Soo Han, Joo Sung Kim
The American Journal of the Medical Sciences.2017; 353(5): 439. CrossRef
Function of obestatin in the digestive system
Yue-Xian Xing, Liu Yang, Hong-Yu Kuang, Xin-Yuan Gao, Hao-Ling Liu
Nutrition.2017; 34: 21. CrossRef
NF-kappa B activation correlates with disease phenotype in Crohn’s disease
Yoo Min Han, Jaemoon Koh, Ji Won Kim, Changhyun Lee, Seong-Joon Koh, ByeongGwan Kim, Kook Lae Lee, Jong Pil Im, Joo Sung Kim, Gernot Sellge
PLOS ONE.2017; 12(7): e0182071. CrossRef
The obestatin/ghrelin ratio and ghrelin genetics in adult celiac patients before and after a gluten-free diet, in irritable bowel syndrome patients and healthy individuals
Francesco Russo, Guglielmina Chimienti, Michele Linsalata, Caterina Clemente, Antonella Orlando, Giuseppe Riezzo
European Journal of Gastroenterology & Hepatology.2017; 29(2): 160. CrossRef
Plasma ghrelin level and plasma ghrelin/obestatin ratio are related to intestinal metaplasia in elderly patients with functional dyspepsia
Su Hwan Kim, Ji Won Kim, Junsu Byun, Ji Bong Jeong, Byeong Gwan Kim, Kook Lae Lee, Zane B Andrews
PLOS ONE.2017; 12(4): e0175231. CrossRef
Plasma ghrelin and leptin in patients with inflammatory bowel disease and its association with nutritional status
Firas A. Ghomraoui, Sami T. Alotaibi, Meshal A. Alharthi, Saeed S. Asiri, Majid A. Almadi, Othman R. Alharbi, Nahla A. Azzam, Abdulrahman M. Aljebreen, Maria Saeed, Baraa Hajkhder, Waleed Saeed, Mohammad A. Alzoghaibi
Saudi Journal of Gastroenterology.2017; 23(3): 199. CrossRef
Obestatin as a key regulator of metabolism and cardiovascular function with emerging therapeutic potential for diabetes
Elaine Cowan, Kerry J Burch, Brian D Green, David J Grieve
British Journal of Pharmacology.2016; 173(14): 2165. CrossRef
Obestatin Accelerates the Healing of Acetic Acid‐Induced Colitis in Rats
Aleksandra Matuszyk, Piotr Ceranowicz, Zygmunt Warzecha, Jakub Cieszkowski, Joanna Bonior, Jolanta Jaworek, Beata Kuśnierz-Cabala, Peter Konturek, Tadeusz Ambroży, Artur Dembiński, Tanea T. Reed
Oxidative Medicine and Cellular Longevity.2016;[Epub] CrossRef
Ghrelin receptor modulates T helper cells during intestinal inflammation
M. Di Giovangiulio, N. Stakenborg, G. Bosmans, E. Meroni, G. Farro, P. J. Gomez‐Pinilla, I. Depoortere, G. E. Boeckxstaens, G. Matteoli
Neurogastroenterology & Motility.2015; 27(11): 1542. CrossRef

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The Changes in Etiology and Clinical Features of Non-Traumatic Small Bowel Perforation: Byeong Gwan Kim, Ji Won Kim, Kook Lae Lee, Jae Kyung Lee, Ji Bong Jeong; Intest Res 2012;10(2):189-195. Published online April 30, 2012; DOI: https://doi.org/10.5217/ir.2012.10.2.189

Abstract PDF: Background/Aims
We investigated the clinical features, and treatment outcomes in patients with non-traumatic small bowel perforations and compared these results to the previous study with patients who were diagnosed between 1997 and 2002. Methods: Patients who diagnosed non-traumatic small bowel perforation between January 2003 and December 2008 were reviewed retrospectively. Results: Of 38 patients of non-traumatic small bowel perforation, the most common etiologies were Crohn's disease (CD) (36.8%), followed by intestinal tuberculosis (ITB) (28.9%) and primary malignancy (15.8%). In the study of 2002, however, the most common etiologies were idiopathic (39.3%), followed by mechanical obstruction (28.6%) and infectious enteritis (14.3%). Of 38 cases, 8 perforation sites were found in the jejunum and 30 in the ileum. The number of perforations was single in 20, two in 15, and over 2 in 3 cases. Twenty-five patients were treated with resection and anastomosis, nine patients with primary closure, and four patients with both procedures. The site and number of perforations, surgical methods, and post-operative complication rates were similar to those of 2002. The perforation patients with ITB had more frequent night sweats and pulmonary tuberculosis findings than those with CD. Conclusions: Although the clinical features and surgical outcomes in the 2009 study were similar to those of the previous study conducted in 2003, the etiologies of perforations were different; CD and ITB were two most common etiologies. In addition, clinical characteristics such as night sweats or pulmonary tuberculosis were suggestive findings for the diagnosis of ITB. (Intest Res 2012;10: 0-195)

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A Case of Primary Pneumatosis Cystoides Intestinalis in a Patient with Chronic Abdominal Pain: Joon Suk Kim, Soon Beom Kwon, Won Kim, Yong Jin Jung, Ji Bong Jeong, Ji Won Kim, Byung Kwan Kim, Kook Lae Lee; Intest Res 2011;9(1):40-45. Published online April 30, 2011; DOI: https://doi.org/10.5217/ir.2011.9.1.40

Abstract PDF

Pneumatosis cystoides intestinalis is a rare phenomenon presenting with multiple gas-filled cysts in the submucosal or subserosal layer of the gastrointestinal tract. Pneumatosis cystoides intestinalis can occur as a primary or secondary disease with an underlying etiology. We recently managed a case of primary pneumatosis cystoides intestinalis in a 42-year-old man with chronic abdominal pain. The case is presented with a review of the literature. (Intest Res 2011;9: 10-45)

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A Case with Primary Pneumatosis Cystoides Treated after Colonoscopic Endoscopic Mucosal Resection
Suk Jae Hahn, Hyoun Woo Kang, Jun Kyu Lee
The Korean Journal of Gastroenterology.2014; 64(2): 119. CrossRef

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Palliative Self-expanding Metal Stents in the Treatment of Malignant Colorectal Obstruction: Ji Bong Jeong, Kook Lae Lee, Soon Beom Kwon, Joon Suk Kim, Jae Kyung Lee, Won Kim, Yong Jin Jung, Ji Won Kim, Byeong Gwan Kim; Intest Res 2010;8(2):135-141. Published online December 30, 2010; DOI: https://doi.org/10.5217/ir.2010.8.2.135

Abstract PDF

Background/Aims
This study was designed to evaluate the outcomes of self-expanding metal stents (SEMS) as palliative treatment for malignant obstruction of the colon and rectum. Methods: From January 2003 to September 2009, 28 patients (12 men and 16 women) with malignant colorectal obstruction received placement of uncovered or covered stents for palliative purposes under endoscopic or fluoroscopic guidance. The rates of technical success, clinical success, and the complications associated with stent insertion, patient survival, and long-term stent patency were evaluated. Results: The technical and clinical success rates were 100% (28/28) and 89.3% (25/28), respectively. Among the 25 patients with technical and clinical success, seven patients (28%) experienced complications: A case of perforation (n=1) was managed by surgical intervention, cases of tumor ingrowth (n=4), tumor ingrowth and overgrowth (n=1), and tumor overgrowth (n=1) were managed successfully with an additional stent. The median survival duration was 128.0±54.8 days. The median stent patency duration was 93.0±29.1 days, and the patency rates at 30, 90, and 180 days were 92%, 52%, and 25%, respectively. Conclusions: The placement of a self-expanding metal stent was safe and effective palliative treatment for malignant colorectal obstruction. Stent-associated complications can be managed with the placement of additional stents in the majority of the patients and long-term stent patency is favorable. (Intest Res 2010;8:135-141)

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Colorectal Stents: Current Status
Jeong-Mi Lee, Jeong-Sik Byeon
Clinical Endoscopy.2015; 48(3): 194. CrossRef

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Clinical Features and Therapeutic Responses of Abdominal Actinomycosis: Ji Won Kim, Ji Bong Jeong, Yong Jin Jung, Byung Kwan Kim, Kook Lae Lee, Su Jong Yu, Mi Na Kim, Joo Sung Kim, Hyun Chae Jung, In Sung Song; Intest Res 2007;5(2):177-183. Published online December 30, 2007

Abstract PDF: Background/Aims
Abdominal actinomycosis is a rare entity and difficult to differentiate from a malignant neoplasm. A study of clinical features and therapeutic responses will contribute to the understanding of this disease. Methods: We analyzed the clinical features and therapeutic responses of 12 cases of abdominal actinomycosis from 1989 to 2007. Results: The male to female ratio of patients was 1：1, and the patients had a median age of 50 years (range 38-60 years). Abdominal pain was the most common symptom, and seven of twelve patients had a history of abdominal surgery, trauma, DM or IUD (intrauterine device) use. An abdominal CT examination revealed infiltrative lesions with disruption of the tissue plane in eight cases, and colonoscopic findings showed luminal stenosis, nodular lesions and ulceration in four cases. Surgical resection was performed in eleven cases with a right hemicolectomy with or without a salpingo-ooporectomy, a left hemicolectomy or mass excision. Of the eleven patients who underwent surgical resection, seven patients received intravenous penicillin G (10-15×106 U) followed by administration of oral antibiotics for a median 8 months (range 4-12 months) according to the presence of symptoms and signs. Conclusions: With combined adequate surgical resection and high-dose antibiotic therapy, the therapeutic responses are favorable in most of the abdominal actinomycosis patients. (Intest Res 2007;5:177-183)

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The Effect of DA-6034, a Synthetic Derivative of Flavonoid, on NF-κB Activity Stimulated with Lipopolysaccharide and Tumor Necrosis actor-α in Human Colonic Epithelial Cell Line: Ji Won Kim, Yong-Jin Jung, Ji Bong Jeong, Byeong Gwan Kim, Kook Lae Lee, Joo Sung Kim, Hyun Chae Jung, In Sung Song; Intest Res 2005;3(1):38-47. Published online June 30, 2005

Abstract PDF: Background/Aims
The nuclear factor-κB (NF-κB) is associated with expression of proinflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8). DA-6034, a derivative of flavonoid, has shown a potent anti-inflammatory effect in IBD animal model. The aim of this study was to characterize the anti-inflammatory activity of DA-6034 in terms of regulation of NF-κB. Methods: HT-29 cells were stimulated with lipopolysaccharide (LPS) or TNF-α alone or pretreated with DA-6034. The influence of DA-6034 on NF-κB DNA binding activity and inhibitory protein κB (IκB) activity was determined using an electrophoretic mobility shift assay (EMSA) and Western blot analysis. The RT-PCR method was used to determine the degree of gene expression of TNF-α and IL-8. Production of TNF-α and IL-8 protein was measured by ELISA. Results: DA-6034 prevented NF-κB activation stimulated with LPS and TNF-α and inhibited LPS- and TNF-α-induced IκB degradation. LPS-induced TNF-α mRNA expression and TNF-α-induced IL-8 mRNA expression were significantly decreased by DA-6034 pretreatment as compared to the absence of DA-6034 pretreatment. Conclusions: These results suggest that the inhibitory effect of DA-6034 on the production of TNF-α in LPS-stimulated and IL-8 in TNF-α-stimulated HT-29 cells may involve transcription regulation by suppression of NF-κB activation by interfering with IκB degradation. (Intest Res 2005; 3:38-47)

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Expression of Human T cell-activating CXC Chemokines in inflammatory bowel disease: Byeong Gwan Kim, Ji Won Kim, Ji Bong Jeong, Geum Yeon Kwak, Kook Lae Lee, Young Soo Park, Na Young Kim, Dong Ho Lee, Joo Sung Kim, Hyun Chae Jung, In Sung Song; Intest Res 2004;2(2):58-64. Published online December 22, 2004

Abstract PDF: Background/Aims
Colonic epithelial cells are increasingly recognized as playing an important role in host defense against microorganisms in the intestinal lumen and in inflammatory responses. When human intestinal epithelial cells are stimulated with proinflammatory cytokines or infected with microbial pathogens, they up-regulate a program of proinflammatory genes whose products are chemoattractant neutrophils and monocytes. However, little is known about the regulated production of T-cell chemoattractants by the intestinal epithelium. Methods: We studied chemokine (IP-10, Mig, I-TAC) expression of the human colonic mucosa by using enzyme-linked immunosorbent assay. Results: Expression of T-cell chemokine (IP-10, Mig, I-TAC) was increased in the mucosa of patients with Crohn's disease and ulcerative colitis. The production level of T-cell chemokine (IP-10, Mig, I-TAC) was decreased in the mucosa of patients with Crohn's disease after remission. Conclusions: Our finding indicated that under inflammatory conditions, mucosal T-cell chemokine production increased and attracted inflammatory cells. This result suggests that, at least in an inflammatory process, T-cell chemokine (IP-10, Mig, I-TAC) play a role in the pathogenesis of inflammatory bowel disease. (Intestinal Research 2004;2:58-64)

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