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Comparative Value of Colonic Tissue Culture and Stool Culture for Diagnosis of Acute Infectious Colitis
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Chang Soo Eun, Dong Soo Han, Jong Pyo Kim, Hang Lak Lee, Jin Bae Kim, Joon Yong Park, Yong Chul Jeon, Joo Hyun Sohn, Joon Soo Hahm
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Intest Res 2004;2(2):83-88. Published online December 22, 2004
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 Abstract
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- Background/Aims
Although the diagnosis of acute infectious diarrhea can be easily suggested by clinical features, identification of the causative organism is mandatory for both accurate diagnoses and epidemiological investigations. The aim of this study was to compare the accuracy of culture of biopsy specimens obtained during colonoscopy with that of stool culture in acute infectious colitis. Methods: From March 1996 to July 2001, forty-five patients who were suspected of having acute infectious colitis were enrolled. In all patients, fecal specimens and colonic tissues excised during colonoscopy were both obtained and then cultured. Results: In stool examinations, WBC and occult blood were positive in 15 (33.3%) and 14 (31.1%) cases, respectively. In culture study, some causative microorganisms were identified in 18 (40%) of the 45 cases investigated. Most common pathogen was Salmonella species (12 cases). Whereas culture of the colonic tissue biopsy specimens was positive for bacteria in 10 of 45 cases (22.2%), stool culture revealed pathogen in 13 of 45 cases (28.9%). In 5 cases, both stool and colonic tissue biopsy specimens were positive for bacteria. Conclusions: Our findings suggest that both colonic tissue culture and stool culture may have a complementary role in diagnosis of acute infectious colitis. (Intestinal Research 2004;2:83-88)
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Clinical Usage of Probiotics and Its Mechanism of Action
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Dong Soo Han, Joon Yong Park
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Intest Res 2004;2(1):5-10. Published online April 16, 2004
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Abstract
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- Probiotics has been prescribed for various medical purposes. The benefit of using probiotics has been clarified in antibiotics associated diarrhea, travelers' diarrhea, acute diarrhea, diarrhea in the pediatric field, functional diarrhea and some part of inflammatory bowel disease. However, the mechanism of action of probiotics is still in the investigation. Its functions of excreting bacterial products, adhesion to bowel wall, competition with other bacteria, and promoting mucin secretion from bowel mucosa have been discussed as the mechanism of action of probiotics. Recently the immune modulation of probiotics started to be regarded as the main part of its mechanism of action. Probiotics may produce its immune modulation by modifying the activation of Toll-like receptor: the main receptor of inducing innate immunity. (Intestinal Research 2004;2:5-10)
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