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Clinical Course of Intestinal BehcӇet's Disease according tothe Characteristics of Ulcer in Colonoscopy
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Min Cheul Kim, Sung Jae Shin, Sun Gyo Lim, Kyung Rok Lee, Hak Woo, Sang Jo Choi, Jung Soo Jo, Jung Ho Eum, Dong Youb Cha, Jae Chul Hwang, Ki Myung Lee, Kwang Jae Lee, Jin Hong Kim
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Intest Res 2010;8(1):40-47. Published online June 30, 2010
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DOI: https://doi.org/10.5217/ir.2010.8.1.40
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Abstract
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- Background/Aims
Intestinal involvement with bleeding and perforation is one of the main causes of morbidity and mortality in patients with Behçet's disease (BD); however, the clinical course of intestinal BD has not been defined. The aim of this study was to determine the clinical course of intestinal BD based on the characteristics of ulcers visualized during colonoscopy. Methods: We retrospectively reviewed the medical records and colonoscopic findings of 41 patients with intestinal BD. All patients were classified into subgroups according to ulcer depth, size, and number, and we analyzed the clinical manifestations, subset type of BD, medications, surgical procedures, and relapse rate among the subgroups. Results: The median age at the time of diagnosis was 38 years (range, 18-74 years); 25 patients were females (M:F=1:1.56). Abdominal pain (n=40), diarrhea (n=27), and RLQ tenderness (n=21) were common symptoms. The number of complete, incomplete, and suspected types was 3, 17, and 21, respectively. In an analysis according to ulcer depth, the rate of steroid use and intestinal surgeries was more frequent in the deep ulcer group compared with the aphthous and shallow ulcer groups (50.0% vs. 0% vs. 17.6%; P=0.012; 42.9% vs. 0% vs. 23.5%: P=0.013) The rate of steroid use and relapse tended to be higher as the size of the ulcer increased; however, there was no difference in the rates of steroid use, surgeries, and relapse based on the number of intestinal ulcers. Conclusions: The prognosis was worse in patients with intestinal BD who have deeper and larger ulcers. Therefore, we suggest that such patients need to be treated aggressively. (Intest Res 2010;8:40-47)
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Citations
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- Simultaneous Involvement of Nervous and Gastrointestinal Systems in Behçet's Disease
Jae Yeol Lee, Ji-Youn Park, En Hyung Kim, Mi Jin Hee Tak, Eun-So Lee Annals of Dermatology.2012; 24(2): 225. CrossRef
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