- Colorectal neoplasia
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Development and validation of a scoring system for advanced colorectal neoplasm in young Korean subjects less than age 50 years
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Ji Yeon Kim, Sungkyoung Choi, Taesung Park, Seul Ki Kim, Yoon Suk Jung, Jung Ho Park, Hong Joo Kim, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Kyu Yong Choi, Dong Il Park
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Intest Res 2019;17(2):253-264. Published online November 20, 2018
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DOI: https://doi.org/10.5217/ir.2018.00062
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 Abstract
 PDF PubReader ePub
- Background/Aims
Colorectal cancer incidence among patients aged ≤50 years is increasing. This study aimed to develop and validate an advanced colorectal neoplasm (ACRN) screening model for young adults aged <50 years in Korea.
Methods
This retrospective cross-sectional study included 59,575 consecutive asymptomatic Koreans who underwent screening colonoscopy between 2003 and 2012 at a single comprehensive health care center. Young Adult Colorectal Screening (YCS) score was developed as an optimized risk stratification model for ACRN using multivariate analysis and was internally validated. The predictive power and diagnostic performance of YCS score was compared with those of Asia-Pacific Colorectal Screening (APCS) and Korean Colorectal Screening (KCS) scores.
Results
41,702 and 17,873 subjects were randomly allocated into the derivation and validation cohorts, respectively, by examination year. ACRN prevalence was 0.9% in both cohorts. YCS score comprised sex, age, alcohol, smoking, obesity, glucose metabolism abnormality, and family history of CRC, with score ranges of 0 to 10. In the validation cohort, ACRN prevalence was 0.6% in the low-risk tier (score, 0–4), 1.5% in the moderate-risk tier (score, 5–7), and 3.4% in the high-risk tier (score, 8–10). ACRN risk increased 2.5-fold (95%CI, 1.8–3.4) in the moderate-risk tier and 5.8-fold (95%CI, 3.4–9.8) in the high-risk tier compared with the low-risk tier. YCS score identified better balanced accuracy (53.9%) than APCS (51.5%) and KCS (50.7%) scores and had relatively good discriminative power (area under the curve=0.660).
Conclusions
YCS score based on clinical and laboratory risk factors was clinically effective and beneficial for predicting ACRN risk and targeting screening colonoscopy in adults aged <50 years.
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Citations
Citations to this article as recorded by  - Response to commentaries on “Performance of the Asia‐Pacific colorectal screening score in stratifying the risk of advanced colorectal neoplasia: A meta‐analysis and systematic review”
MN Luu, DT Quach
Journal of Gastroenterology and Hepatology.2025; 40(1): 337. CrossRef - Family History of Colorectal Cancer and the Risk of Colorectal Neoplasia: A Systematic Review and Meta-Analysis
Kai Gao, Huyi Jin, Yi Yang, Jiayu Li, Yuanliang He, Ruiyao Zhou, Wanting Zhang, Xiangrong Gao, Zongming Yang, Mengling Tang, Jianbing Wang, Ding Ye, Kun Chen, Mingjuan Jin
American Journal of Gastroenterology.2025; 120(3): 531. CrossRef - Performance of the Asia–Pacific Colorectal Screening score in stratifying the risk of advanced colorectal neoplasia: A meta‐analysis and systematic review
Mai Ngoc Luu, Nhi Ai Trinh, Truc Le Thanh Tran, Thinh Phuong Dang, Toru Hiyama, Duc Trong Quach
Journal of Gastroenterology and Hepatology.2024; 39(6): 1000. CrossRef - Updated epidemiology of gastrointestinal cancers in East Asia
Junjie Huang, Don Eliseo Lucero-Prisno, Lin Zhang, Wanghong Xu, Sunny H. Wong, Siew C. Ng, Martin C. S. Wong
Nature Reviews Gastroenterology & Hepatology.2023; 20(5): 271. CrossRef - From Algorithms to Clinical Utility: A Systematic Review of Individualized Risk Prediction Models for Colorectal Cancer
Deborah Jael Herrera, Wessel van de Veerdonk, Daiane Maria Seibert, Moges Muluneh Boke, Claudia Gutiérrez-Ortiz, Nigus Bililign Yimer, Karen Feyen, Allegra Ferrari, Guido Van Hal
Gastrointestinal Disorders.2023; 5(4): 549. CrossRef - Emergence of a New Optical Marker for Colorectal Neoplasms: To What Extent Should We Accept It?
Han Hee Lee
Clinical Endoscopy.2022; 55(2): 315. CrossRef - Is early-onset cancer an emerging global epidemic? Current evidence and future implications
Tomotaka Ugai, Naoko Sasamoto, Hwa-Young Lee, Mariko Ando, Mingyang Song, Rulla M. Tamimi, Ichiro Kawachi, Peter T. Campbell, Edward L. Giovannucci, Elisabete Weiderpass, Timothy R. Rebbeck, Shuji Ogino
Nature Reviews Clinical Oncology.2022; 19(10): 656. CrossRef - Strategies for colorectal cancer screening and post-polypectomy surveillance for young adults under age 50
Yoon Suk Jung
Precision and Future Medicine.2021; 5(2): 69. CrossRef - How to Choose the Optimal Bowel Preparation Regimen for Colonoscopy
Ji Eun Na, Eun Ran Kim
The Ewha Medical Journal.2021; 44(4): 122. CrossRef - The Role of Diet and Lifestyle in Early-Onset Colorectal Cancer: A Systematic Review
Marta Puzzono, Alessandro Mannucci, Simone Grannò, Raffaella Alessia Zuppardo, Andrea Galli, Silvio Danese, Giulia Martina Cavestro
Cancers.2021; 13(23): 5933. CrossRef - Association between waist circumference and risk of colorectal neoplasia in normal‐weight adults
Yoon Suk Jung, Nam Hee Kim, Hyo‐Joon Yang, Soo‐Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn
Journal of Gastroenterology and Hepatology.2020; 35(1): 43. CrossRef - Risk prediction rule for advanced neoplasia on screening colonoscopy for average-risk individuals
Ala I Sharara, Ali El Mokahal, Ali H Harb, Natalia Khalaf, Fayez S Sarkis, Mustapha M El-Halabi, Nabil M Mansour, Ahmad Malli, Robert Habib
World Journal of Gastroenterology.2020; 26(37): 5705. CrossRef - Risk Factors Associated With Young-Onset Colorectal Adenomas and Cancer: A Systematic Review and Meta-Analysis of Observational Research
Genevieve Breau, Ursula Ellis
Cancer Control.2020;[Epub] CrossRef - Prevalence and risk factors of colorectal cancer in Asia
Martin CS Wong, Hanyue Ding, Jingxuan Wang, Paul SF Chan, Junjie Huang
Intestinal Research.2019; 17(3): 317. CrossRef
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14
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Comparison of the efficacy of disinfectants in automated endoscope reprocessors for colonoscopes: tertiary amine compound (Sencron2®) versus ortho-phthalaldehyde (Cidex®OPA)
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Hyun Il Seo, Dae Sung Lee, Eun Mi Yoon, Min-Jung Kwon, Hyosoon Park, Yoon Suk Jung, Jung Ho Park, Chong Il Sohn, Dong Il Park
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Intest Res 2016;14(2):178-182. Published online April 27, 2016
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DOI: https://doi.org/10.5217/ir.2016.14.2.178
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Abstract
PDFPubReaderePub
- <b>Background/Aims</b><br/>
To prevent the transmission of pathogens by endoscopes, following established reprocessing guidelines is critical. An ideal reprocessing step is simple, fast, and inexpensive. Here, we evaluated and compared the efficacy and safety of two disinfectants, a tertiary amine compound (TAC) and ortho-phthalaldehyde (OPA). MethodsA total of 100 colonoscopes were randomly reprocessed using two same automated endoscope reprocessors, according to disinfectant. The exposure time was 10 minutes for 0.55% OPA (Cidex® OPA, Johnson & Johnson) and 5 minutes for 4% TAC (Sencron2®, Bab Gencel Pharma & Chemical Ind. Co.). Three culture samples were obtained from each colonoscope after reprocessing. ResultsA total of nine samples were positive among the 300 culture samples. The positive culture rate was not statistically different between the two groups (4% for OPA and 2% for TAC, P=0.501). There were no incidents related to safety during the study period. ConclusionsTAC was non-inferior in terms of reprocessing efficacy to OPA and was safe to use. Therefore, TAC seems to be a good alternative disinfectant with a relatively short exposure time and is also less expensive than OPA.
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Citations
Citations to this article as recorded by - What doesn’t kill biofilm, makes them stronger: critical methodological considerations for endoscope reprocessing
R. Kanaujia, A. Sharma, M. Biswal, V. Singh
Journal of Hospital Infection.2025; 156: 135. CrossRef - Synthesis, Characterization and Investigation of Antimicrobial Activity of Orthophtaldehyde Nanoflowers
Gülten CAN SEZGİN, Nilay ILDİZ
Middle Black Sea Journal of Health Science.2023; 9(2): 245. CrossRef - A Manufacturer and User Facility Device Experience Analysis of Upper Aerodigestive Endoscopy Contamination: Is Flexible Laryngoscopy Different?
Roy Jiang, David A. Kasle, Faisal Alzahrani, Nikita Kohli, Michael Z. Lerner
The Laryngoscope.2021; 131(3): 598. CrossRef - Electrochemical and Spectrometric Study of Reactivity of Orthophthalaldehyde with Hydroxylamine: Mechanistic Considerations
Joël Donkeng‐Dazie, Jiří Urban, Jiří Ludvík
ChemistrySelect.2021; 6(20): 4881. CrossRef - Reactivity of orthophthalaldehyde with aliphatic, alicyclic and aromatic primary diamines: Electrochemical study and mechanistic considerations
Joël Donkeng Dazie, Alan Liška, Jiří Urban, Jiří Ludvík
Journal of Electroanalytical Chemistry.2018; 821: 131. CrossRef - Efficacy of Peracetic Acid (EndoPA®) for Disinfection of Endoscopes
Ji Min Lee, Kang-Moon Lee, Dae Bum Kim, Se Eun Go, Sungwoo Ko, Yoongoo Kang, Solim Hong
The Korean Journal of Gastroenterology.2018; 71(6): 319. CrossRef - Planarity of substituted pyrrole and furan rings in (3R*, 1′S*, 3′R*)-3-(1′-tert-butylamino-1′H, 3′ H-benzo[c]furan-3′-yl)-2-tert-butyl-2,3-dihydro-1H-benzo[c]pyrrol-1-one
Joel Donkeng Dazie, Alan Liška, Jiří Ludvík, Jan Fábry, Michal Dušek, Václav Eigner
Zeitschrift für Kristallographie - Crystalline Materials.2017; 232(6): 441. CrossRef
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The prevalence and clinical characteristics of anemia in Korean patients with inflammatory bowel disease
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Dae Sung Lee, Ki Bae Bang, Ji Yeon Kim, Yoon Suk Jung, Jung Ho Park, Hong Joo Kim, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Kyu Young Choi, Dong Il Park
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Intest Res 2016;14(1):43-49. Published online January 26, 2016
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DOI: https://doi.org/10.5217/ir.2016.14.1.43
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Abstract
PDFPubReaderePub
- <b>Background/Aims</b><br/>
Quality of life is closely related to anemia in patients with inflammatory bowel disease (IBD). Several studies have reported on anemia in patients with IBD in Western countries. This study investigated the prevalence and clinical characteristics of anemia in Korean patients with IBD. MethodsWe reviewed the medical records of 92 patients with ulcerative colitis (UC) and 76 patients with Crohn's disease (CD) who were followed regularly at a single tertiary medical center in Korea between January 2003 and December 2012. Hemoglobin (Hb) thresholds used to define anemia were <13.0 g/dL in men and <12.0 g/dL in women according to the World Health Organization criteria. We chose the lowest Hb level in each year as a representative value because Hb levels changed at each examination and anemia was associated with disease deterioration. The relationship between clinical variables and lowest Hb level was assessed. ResultsThe prevalence of anemia was 36.3% in patients with UC and 41.6% in patients with CD. Anemia in patients with CD was associated with hospital admission, 5-aminosalicylate (5-ASA) and infliximab treatment in men. Anemia in patients with UC was associated with hospital admission, oral steroid use, thiopurine and infliximab treatment in men. ConclusionsThe prevalence of anemia in Korean patients with IBD was comparable to that of patients in Western countries. Anemia was associated with male patients with CD who were admitted to the hospital and received medications including 5-ASA and infliximab, and men with UC who were admitted to the hospital and received medications including oral steroids, thiopurine and infliximab.
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Citations
Citations to this article as recorded by - Clinical characteristics and north-south differences of inflammatory bowel disease in China: A cross-sectional study and meta-analysis
Qi Liang, Bo Qu, Chunye Li, Yue Hu, Chunyi Yang, Tingting Yang, Yuzhu Di, Hui Li
Frigid Zone Medicine.2024; 4(1): 23. CrossRef - Clinical and Laboratory Characteristics of Anaemia in Hospitalized Patients with Inflammatory Bowel Disease
Małgorzata Woźniak, Anna Borkowska, Marta Jastrzębska, Marcin Sochal, Ewa Małecka-Wojciesko, Renata Talar-Wojnarowska
Journal of Clinical Medicine.2023; 12(7): 2447. CrossRef - Ferric carboxymaltose for anemia in Crohn’s disease patients at a tertiary center: A retrospective observational cohort study
Natália Souza Nunes Siqueira, Livia Bitencourt Pascoal, Bruno Lima Rodrigues, Marina Moreira de Castro, Alan Sidnei Corrêa Martins, Dante Orsetti Silva Araújo, Luis Eduardo Miani Gomes, Michel Gardere Camargo, Maria de Lourdes Setsuko Ayrizono, Raquel Fra
World Journal of Clinical Cases.2023; 11(12): 2740. CrossRef - ANEMIA AND IRON DEFICIENCY IN INFLAMMATORY BOWEL DISEASE PATIENTS IN A REFERRAL CENTER IN BRAZIL: PREVALENCE AND RISK FACTORS
Rogério Serafim PARRA, Marley Ribeiro FEITOSA, Sandro da Costa FERREIRA, José Joaquim Ribeiro da ROCHA, Luiz Ernesto de Almeida TRONCON, Omar FÉRES
Arquivos de Gastroenterologia.2020; 57(3): 272. CrossRef - Frequency, types, and treatment of anemia in Turkish patients with inflammatory bowel disease
Göksel Bengi, Hatice Keyvan, Seda Bayrak Durmaz, Hale Akpınar
World Journal of Gastroenterology.2018; 24(36): 4186. CrossRef - Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease
Seong Jae Yeo, Hyun Seok Lee, Byung Ik Jang, Eun Soo Kim, Seong Woo Jeon, Sung Kook Kim, Kyeong Ok Kim, Yoo Jin Lee, Hyun Jik Lee, Kyung Sik Park, Yun Jin Jung, Eun Young Kim, Chang Heon Yang
Intestinal Research.2018; 16(3): 400. CrossRef - Should asymptomatic young men with iron deficiency anemia necessarily undergo endoscopy?
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
The Korean Journal of Internal Medicine.2018; 33(6): 1084. CrossRef - Anemia at the time of diagnosis of inflammatory bowel disease: Prevalence and associated factors in adolescent and adult patients
Alfredo J. Lucendo, Ángel Arias, Óscar Roncero, Daniel Hervías, Cristina Verdejo, Carmen Naveas-Polo, Abdelmouneim Bouhmidi, Rufo Lorente, Luis Miguel Alcázar, Irina Salueña, Julio A. García-Quiñones, María Jesús Carrillo-Ramos
Digestive and Liver Disease.2017; 49(4): 405. CrossRef
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Prevalence, Clinicopathologic Characteristics, and Predictors of Interval Colorectal Cancers in Korean Population
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Chang Joon Kim, Yoon Suk Jung, Jung Ho Park, Hong Joo Kim, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Shin Yeong Lee, Hwa Mok Kim, Ki Bae Bang, Dae Sung Lee, Dong Il Park
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Intest Res 2013;11(3):178-183. Published online July 30, 2013
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DOI: https://doi.org/10.5217/ir.2013.11.3.178
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Abstract
PDF
- Background/Aims
A subset of patients may develop colorectal cancer after a colonoscopy that was negative for carcinoma. These missed or de novo developed lesions were termed as interval cancers. Many studies regarding interval cancer have been conducted in Western countries, whereas very limited data are available in Asian populations. Therefore, the purpose of this study was to investigate prevalence, clinicopathologic features, and predictors of interval colorectal cancers in the Korean population. Methods: Interval cancer was defined as a cancer that is diagnosed within 5 years of a negative colonoscopy result. Among the patients who were diagnosed colorectal cancers at Kangbuk Samsung Hospital from January 2007 to April 2012, clinicopathologic characteristics of interval cancers were compared with those of sporadic cancers. Results: Among the 785 patients, 482 responded to telephone calls. Of these, 30 (6.2%) developed interval cancers. Finally, 28 patients who had interval cancers were compared with 415 patients who had sporadic cancers. Interval cancer group was significantly younger and more frequent in the right side colon than sporadic cancer group. There was no differences in sex, tumor size, differentiation, and staging between two groups. In multivariate analysis, young age and right side colon cancer were independent factors associated with an interval cancer. Conclusions: A significant proportion of Korean patients developed interval colorectal cancer, especially at the young age and in the proximal colon. (Intest Res 2013;11:178-183)
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Citations
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Jong Yoon Lee
Journal of Digestive Cancer Research.2024; 12(3): 160. CrossRef - Clinical and endoscopic characteristics of sessile serrated lesions with dysplasia/carcinoma
Peel Jung, Hyung Wook Kim, Su Bum Park, Dae Hwan Kang, Cheol Woong Choi, Su Jin Kim, Hyeong Seok Nam, Dae Gon Ryu, Dong Hoon Shin, Joo Young Na, Mi Sook Yun
The Korean Journal of Internal Medicine.2023; 38(3): 349. CrossRef - Post-colonoscopy Colorectal Cancer: Causes and Prevention of Interval Colorectal Cancer
Jong Yoon Lee, Jong Hoon Lee
The Korean Journal of Gastroenterology.2020; 75(6): 314. CrossRef - Frequency and Characteristics of Interval Colorectal Cancer in Actual Clinical Practice: A KASID Multicenter Study
Kyeong Ok Kim, Kyu Chan Huh, Sung Pil Hong, Won Hee Kim, Hyuk Yoon, Sang Wook Kim, Yeon Soo Kim, Jong Ha Park, Jun Lee, Bum Jae Lee, Young Sook Park
Gut and Liver.2018; 12(5): 537. CrossRef - Molecular Imaging of Colorectal Tumors by Targeting Colon Cancer Secreted Protein-2 (CCSP-2)
Jaeil Kim, Eun-ju Do, Helen Moinova, Sang Mun Bae, Ja Young Kang, Seung-Mo Hong, Stephen P. Fink, Jinmyoung Joo, Young-Ah Suh, Se Jin Jang, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Jaewon Choe, Suk-Kyun Yang, Sanfo
Neoplasia.2017; 19(10): 805. CrossRef - External Validation of the Endoscopic Features of Sessile Serrated Adenomas in Expert and Trainee Colonoscopists
Hyo-Joon Yang, Jeong In Lee, Soo-Kyung Park, Yoon Suk Jung, Jin Hee Sohn, Kyu Yong Choi, Dong Il Park
Clinical Endoscopy.2017; 50(3): 279. CrossRef - Comparative Study on Bowel Preparation Efficacy of Ascorbic Acid Containing Polyethylene Glycol by Adding Either Simethicone or 1 L of Water in Health Medical Examination Patients: A Prospective Randomized Controlled Study
Se Hwan Yeo, Jae Hoon Kwak, Yeo Un Kim, Tae Ho Kwon, Jeong Bae Park, Jun Hyung Park, Yong Kook Lee, Yun Jeong Lim, Chang Heon Yang
The Korean Journal of Gastroenterology.2016; 67(4): 189. CrossRef - Microsatellite Instability Status of Interval Colorectal Cancers in a Korean Population
Kil Woo Lee, Soo-Kyung Park, Hyo-Joon Yang, Yoon Suk Jung, Kyu Yong Choi, Kyung Eun Kim, Kyung Uk Jung, Hyung Ook Kim, Hungdai Kim, Ho-Kyung Chun, Dong Il Park
Gut and Liver.2016; 10(5): 781. CrossRef - Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population
Seung Eun Lee, Hee Bum Jo, Won Gun Kwack, Yun Jin Jeong, Yeo-Jin Yoon, Hyoun Woo Kang
World Journal of Gastroenterology.2016; 22(10): 2981. CrossRef - Randomized Controlled Trial of Sodium Phosphate Tablets versus 2 L Polyethylene Glycol Solution for Bowel Cleansing prior to Colonoscopy
Yun Ho Lee, Seong Yeon Jeong, You Sun Kim, Hye Jin Jung, Min Jung Kwon, Cheol Hun Kwak, Song I Bae, Jeong Seop Moon, Ji Won Kim, Su Hwan Kim, Kook Lae Lee
The Korean Journal of Gastroenterology.2015; 65(1): 27. CrossRef - The Risk of Metachronous Advanced Colorectal Neoplasia Rises in Parallel with an Increasing Number of High-Risk Findings at Baseline
Seung Min Lee, Jeong Hwan Kim, In Kyung Sung, Sung Noh Hong
Gut and Liver.2015; 9(6): 741. CrossRef - Rapidly Growing Interval Colon Cancer
Jae Hyun Kim, Moo In Park
The Korean Journal of Gastroenterology.2015; 65(5): 326. CrossRef - Colonoscopy Quality is the Answer for the Emerging Issue of Interval Cancer
Jae Myung Cha
Intestinal Research.2014; 12(2): 110. CrossRef - Interval Cancers after a Negative Colonoscopy Finding in a Korean Population: A Small Step for Gastroenterologists but One Giant Leap for Koreans
Jae Myung Cha
Intestinal Research.2014; 12(2): 169. CrossRef - Author's Reply
Dong Il Park
Intestinal Research.2014; 12(2): 171. CrossRef - Development and Predictor of Interval Colorectal Cancer
Tae-Oh Kim
Intestinal Research.2013; 11(3): 153. CrossRef - What Matters in Colonoscopy?
Hyun Shig Kim
Annals of Coloproctology.2013; 29(6): 223. CrossRef
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Exposure to Diagnostic Radiation in Patients with Inflammatory Bowel Disease: A Single Center Study
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Jae Wan Lim, Yoon Suk Jung, Jung Ho Park, Hong Joo Kim, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Dong Il Park
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Intest Res 2013;11(2):107-112. Published online April 30, 2013
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DOI: https://doi.org/10.5217/ir.2013.11.2.107
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Abstract
PDF
- Background/Aims
Western studies recently reported that patients with inflammatory bowel disease (IBD) are exposed to diagnostic radiation at potentially harmful levels. There is little research, however, on exposure to diagnostic radiation in patients with IBD in Asian areas. The present study assessed cumulative radiation exposure dose in patients with IBD who were treated at a single-tertiary medical center in Korea and analyzed the factors that increased the exposure dose. Methods: Retrospective investigation was performed of the medical records of the patients who were followed up for 1 year or more in a period from January 2003 through November 2011 at Kangbuk Samsung Hospital. Results: Included in the study were 202 patients with IBD: 80 (39.6%) had Crohn's disease (CD) and 122 (60.4%) had ulcerative colitis (UC). The mean follow-up period was 4.2±2.5 years for CD and 4.3±1.4 years for UC. The mean culmulative effective dose (CED) for CD and UC were 39.7 and 11.0 mSv respectively (P<0.001). In CD, factors associated with increased CED were surgery, history of intravenous steroid treatment, and structuring or penetrating disease. Conclusions: A substantial proportion of IBD patients, especially CD patients, were exposed to significantly harmful amounts of diagnostic radiation, mainly due to computed tomography examination. Efforts should be made to reduced diagnostic medical radiation, especially in patients at risk for increased radiation exposure. (Intest Res 2013;11:107-112)
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Seasonal Variation in Flares of Inflammatory Bowel Disease in a Korean Population
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Jae Hyun Jang, Su Hee Lee, Jun Mo Sung, Jung Ho Park, Hong Joo Kim, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Dong Il Park
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Intest Res 2012;10(2):161-167. Published online April 30, 2012
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DOI: https://doi.org/10.5217/ir.2012.10.2.161
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Abstract
PDF
- Background/Aims
Conflicting data have been reported about the seasonal variation in flare-up of inflammatory bowel disease (IBD). The aim of this study was to assess the occurrence of seasonal variations in flare-up of IBD in the Korean population. Methods: Patients with IBD, who underwent more than 1 year of follow-up and showed more than 1 episode of flare-up, were included. Flares of disease were refined as follows; receipt of a new prescription and increasing dose of corticosteroids, 5-ASA or immunosuppressant; hospitalized or operated due to development and worsening of symptoms; elevation of inflammatory marker due to worsening of Crohn's Disease Activity Index (CDAI) or Mayo score. In addition, for patients with more than two episodes of flare-up, they were investigated in a monthly and seasonal pattern. Results: Of 573 patients with IBD, 46 patients with Crohn's disease and 61 patients with ulcerative colitis were enrolled. There was no association between month of the year and flare of Crohn's disease (P=0.06) or ulcerative colitis (P=0.58). Further, no association between season of the year and flare of Crohn's disease (P=0.06) or ulcerative colitis (P=0.68). However, in Crohn's disease who experience 2 or more flare-ups, symptoms occurred more frequently during winter, especially December (P=0.029). Conclusions: In the Korean population, there was no association of seasonal and monthly variation in flares of Crohn's disease and ulcerative colitis. However, in Crohn's disease, individuals with 2 flar-up or more, symptoms occurred more frequently during December. (Intest Res 2012;10: 0-167)
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Citations
Citations to this article as recorded by - Old Age at Diagnosis Is Associated With Favorable Outcomes in Korean Patients With Inflammatory Bowel Disease
Jae Hyuk Choi, Eun Soo Kim, Kwang Bum Cho, Kyung Sik Park, Yoo Jin Lee, Sang Min Lee, Yu Jin Kang, Byung Ik Jang, Kyeong Ok Kim
Intestinal Research.2015; 13(1): 60. CrossRef
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3,042
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A Case of Pulmonary Tuberculosis Misdiagnosed as Lung Metastases after Curative Resection of Early Colon Cancer
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Chang Joon Kim, Dong Il Park, Sung Keun Park, Jung Ho Park, Chong Il Sohn, Woo Kyu Jeon, Young-Ho Kim, Sun-Young Lee
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Intest Res 2007;5(2):196-199. Published online December 30, 2007
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Abstract
PDF
- Early colon cancer can be cured by endoscopic mucosal resection (EMR). However, the possibility of complete resection depends on the depth of cancer invasion. Ten percent of cancers invading the submucosal layer are associated with local lymph node metastasis. Therefore, colon cancers confirmed to invade the submucosal layer after EMR require surgical resection. We treated a woman with adenocarcinoma at the hepatic flexure with submucosal invasion diagnosed after piecemeal EMR. Subsequent right hemicolectomy with lymph node dissection revealed no residual cancer. However, after 21 months, multiple pulmonary nodules were incorrectly diagnosed as pulmonary metastases, based on the radiological findings. The final diagnosis of pulmonary tuberculosis was made after lung metastasectomy. (Intest Res 2007;5:196-199)
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