Intestinal Research

Rui Feng

1 Article

Inflammatory bowel diseases

Risk Factors Associated with Impaired Ovarian Reserve in Young Women of Reproductive Age with Crohn’s Disease: Yue Zhao, Baili Chen, Yao He, Shenghong Zhang, Yun Qiu, Rui Feng, Hongsheng Yang, Zhirong Zeng, Shomron Ben-Horin, Minhu Chen, Ren Mao; Intest Res 2020;18(2):200-209. Published online March 31, 2020; DOI: https://doi.org/10.5217/ir.2019.00103

Background/Aims
Crohn’s disease (CD) primarily affects young female adults of reproductive age. Few studies have been conducted on this population’s ovarian reserve status. The aim of study was to investigate potential risk factors associated with low ovarian reserve, as reflected by serum anti-Müllerian hormone (AMH) in women of reproductive age with CD.
Methods
This was a case-control study. Cases included 87 patients with established CD, and healthy controls were matched by age, height and weight in a 1:1 ratio. Serum AMH levels were measured by enzyme-linked immunosorbent assay.
Results
The average serum AMH level was significantly lower in CD patients than in control group (2.47±2.08 ng/mL vs. 3.87±1.96 ng/mL, respectively, P<0.001). Serum AMH levels were comparable between CD patients and control group under 25 years of age (4.41±1.52 ng/mL vs. 3.49±2.10 ng/mL, P=0.06), however, serum AMH levels were significantly lower in CD patients over 25 years of age compared to control group (P<0.05). Multivariable analysis showed that an age greater than 25 (odds ratio [OR], 10.03; 95% confidence interval [CI], 1.90–52.93, P=0.007), active disease state (OR, 27.99; 95% CI, 6.13–127.95, P<0.001) and thalidomide use (OR, 15.66; 95% CI, 2.22–110.65, P=0.006) were independent risk factors associated with low ovarian reserve (serum AMH levels <2 ng/mL) in CD patients.
Conclusions
Ovarian reserve is impaired in young women of reproductive age with CD. Age over 25 and an active disease state were both independently associated with low ovarian reserve. Thalidomide use could result in impaired ovarian reserve.

Citations

Citations to this article as recorded by

Inflammation and Ovarian Function in Reproductive‐Aged Women
Anneliese Long, Anne Z. Steiner, Amanda L. Thompson, Hannah R. Jahnke, Benjamin S. Harris, Anne Marie Jukic
American Journal of Human Biology.2025;[Epub] CrossRef
Efficacy and Tolerance of Thalidomide in Patients With Very Early Onset Inflammatory Bowel Disease
Matteo Bramuzzo, Fabiola Giudici, Serena Arrigo, Paolo Lionetti, Giovanna Zuin, Claudio Romano, Francesco Graziano, Simona Faraci, Patrizia Alvisi, Sara Signa, Luca Scarallo, Stefano Martelossi, Grazia Di Leo
Inflammatory Bowel Diseases.2024; 30(1): 20. CrossRef
Inhibin B and antiMüllerian hormone as surrogate markers of fertility in male and female Crohn’s disease patients: a case-control study
Ana Gutiérrez, Roser Muñoz-Pérez, Pedro Zapater, Cristina Mira, Andrés Rodríguez, Laura Sempere-Robles, María Eugenia Torregrosa, Rocio Alfayate, Violeta Moreno-Torres, Lorena Bernal, Olivia Belén-Galipienso, Jose Ignacio Cameo, Paula Sirera, Belen Herrer
Frontiers in Medicine.2024;[Epub] CrossRef
Factors associated with decreased ovarian reserve in Crohn's disease: A systematic review and meta‐analysis
Arthur Foulon, Nicolas Richard, Camille Guichard, Clara Yzet, Coraline Breuval, Jean Gondry, Rosalie Cabry‐Goubet, Audrey Michaud, Mathurin Fumery
Acta Obstetricia et Gynecologica Scandinavica.2024; 103(9): 1714. CrossRef
Serum anti-mullerian hormone, sex hormone, and nutrient levels in reproductive age women with celiac disease
Ailifeire Tuerxuntayi, Tian Shi, Beiyao Gao, Yan Feng, Ting Li, Wenjia Hui, Shenglong Xue, Feng Gao
Journal of Assisted Reproduction and Genetics.2024; 41(8): 2129. CrossRef
A Gender Perspective on Coloproctological Diseases: A Narrative Review on Female Disorders
Paola De Nardi, Greta Giacomel, Simone Orlandi, Giulia Poli, Mauro Pozzo, Marcella Rinaldi, Antonella Veglia, Renato Pietroletti
Journal of Clinical Medicine.2024; 13(20): 6136. CrossRef
Management strategies for inflammatory bowel disease before and during pregnancy
Xu-Jie Dai, Zhen Guo
World Chinese Journal of Digestology.2024; 32(11): 803. CrossRef
Inflammatory bowel disease can reduce ovarian reserve function in women: A systematic review and meta-analysis
Lin Guo, Yi Liu, Jiansheng Li, Quan Liu, Bing Liu, Xuewen Shi
Medicine.2023; 102(11): e33113. CrossRef
Inflammatory bowel disease in pregnancy and breastfeeding
Max N. Brondfield, Uma Mahadevan
Nature Reviews Gastroenterology & Hepatology.2023; 20(8): 504. CrossRef
Case report: A pregnant woman with Crohn disease who used ustekinumab to the 3rd trimester developed severe infection
Peng Guo, Wulan Cao
Medicine.2023; 102(48): e36253. CrossRef
Monitoring of Inflammatory Bowel Disease in Pregnancy: A Review of the Different Modalities
Reem Al-jabri, Panu Wetwittayakhlang, Peter L. Lakatos
Journal of Clinical Medicine.2023; 12(23): 7343. CrossRef
General review of pregnancy in inflammatory bowel disease
Elena Santos Pérez, Marta Calvo Moya
Revista Española de Enfermedades Digestivas.2022;[Epub] CrossRef
Inflammatory Bowel Disease and Reproductive Health: From Fertility to Pregnancy—A Narrative Review
Camilla Ronchetti, Federico Cirillo, Noemi Di Segni, Martina Cristodoro, Andrea Busnelli, Paolo Emanuele Levi-Setti
Nutrients.2022; 14(8): 1591. CrossRef
Ovarian reserve and IVF outcomes in patients with inflammatory bowel disease: A systematic review and meta-analysis
Honghao Sun, Jiao Jiao, Feng Tian, Qing Liu, Jiansu Bian, Rongmin Xu, Da Li, Xiuxia Wang, Hong Shu
eClinicalMedicine.2022; 50: 101517. CrossRef
Inflammatory Bowel Disease and Pregnancy
Eugenia Shmidt, Marla C. Dubinsky
American Journal of Gastroenterology.2022; 117(10S): 60. CrossRef
Reproductive Health in IBD Patients
Sanket Patel, Haleh Vaziri
Current Treatment Options in Gastroenterology.2021; 19(2): 237. CrossRef
Ovarian Reserve Assessed by the Anti-Mullerian Hormone and Reproductive Health Parameters in Women With Crohn´s Disease, a Case-Control Study
T. Koller, J. Kollerová, T. Hlavatý, B. Kadlečková, J. Payer
Physiological Research.2021; : S69. CrossRef
THE ROLE OF IMMUNOGLOBULIN A IN THE INFLAMMATORY PROCESS INVOLVING NEUTROPHILS
O.O. Prudnikov, I.M. Prudnikov, V.M. Tsyvkin, A.M. Smirnov, R.I. Yanchiy
Fiziolohichnyĭ zhurnal.2021; 67(5): 44. CrossRef
Update on Pregnancy in Patients with IBD
Rachel W. Winter, Sonia Friedman
Current Treatment Options in Gastroenterology.2020; 18(3): 423. CrossRef

7,132 View
133 Download
16 Web of Science
19 Crossref

Author index