Intestinal Research

Seon Mee Park

4 Articles

Diagnostic and prognostic value of preoperative ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography for colorectal cancer: comparison with conventional computed tomography: Joo Young Lee, Soon Man Yoon, Jeong Tae Kim, Ki Bae Kim, Mi Jin Kim, Jae Geun Park, Taek-Gu Lee, Sang-Jeon Lee, Sung Soo Koong, Joung-Ho Han, Hee Bok Chae, Seon Mee Park, Sei Jin Youn; Intest Res 2017;15(2):208-214. Published online April 27, 2017; DOI: https://doi.org/10.5217/ir.2017.15.2.208

<b>Background/Aims</b><br/>

¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) has been used for preoperative staging of colorectal cancer (CRC). However, the diagnostic accuracy of FDG-PET/CT for detection of lymph node or distant metastasis and its prognostic role have not been well established. We therefore evaluated the diagnostic and prognostic value of FDG-PET/CT in comparison with conventional CT for CRC.

Methods

We investigated 220 patients who underwent preoperative FDG-PET/CT and CT, followed by curative surgery for CRC. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of FDG-PET/CT and CT for detection of lymph node metastasis and distant metastasis were evaluated. In addition, we assessed the findings of FDG-PET/CT and CT according to outcomes, including cancer recurrence and cancer-related death, for evaluation of prognostic value.

Results

For detection of lymph node metastasis, FDG-PET/CT had a sensitivity of 44%, a specificity of 84%, and an accuracy of 67%, compared with 59%, 65%, and 62%, respectively, for CT (P=0.029, P=0.000, and P=0.022). For distant metastasis, FDG-PET/CT had a sensitivity of 79%, a specificity of 94%, and an accuracy of 93%, compared with 79%, 87%, and 86%, respectively, for CT (P=1.000, P=0.004, and P=0.037). In addition, positive findings of lymph node metastasis and distant metastasis on FDG-PET/CT were associated significantly with cancer recurrence or cancer-related death (P=0.009, P=0.001, respectively).

Conclusions

Preoperative FDG-PET/CT had a higher specificity and accuracy compared to CT for detection of lymph node metastasis and distant metastasis of CRC. In addition, FDG-PET/CT could be a valuable prognostic tool for CRC.

Citations

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Nuclear medicine based multimodal molecular imaging facilitates precision medicine for gastrointestinal tumors
Jing Zhao, Fei Wang, Rong-Fu Wang
World Chinese Journal of Digestology.2024; 32(10): 727. CrossRef
Tomographie par émission de positons en cancérologie digestive
C. Aveline, F. Montravers
EMC - Radiologie et imagerie médicale - Abdominale - Digestive.2024; 42(1): 1. CrossRef
Retrospective audit: Utility of PET scan in routine preoperative rectal cancer staging
Michelle Zhiyun Chen, Xinyi Zhang, Milton Mui, Joseph C. H. Kong, Alexander G. Heriot, Jodie Ellis‐Clark
ANZ Journal of Surgery.2023; 93(3): 617. CrossRef
Impact of routine preoperative 18FDG PET/CT on the surgical management of primary colorectal cancer
Mónica Mogollón‐González, Raquel Conde‐Muiño, Antonio Rodríguez‐Fernández, Mar Navarro‐Pelayo, Mireia Domínguez‐Bastante, Pablo Palma
Journal of Surgical Oncology.2023; 128(2): 295. CrossRef
Investigating ultra-low-dose total-body [18F]-FDG PET/CT in colorectal cancer: initial experience
Hui Tan, Danjie Cai, Xiuli Sui, Chi Qi, Wujian Mao, Yiqiu Zhang, Guobing Liu, Haojun Yu, Shuguang Chen, Pengcheng Hu, Jianying Gu, Hongcheng Shi
European Journal of Nuclear Medicine and Molecular Imaging.2022; 49(3): 1002. CrossRef
Tailoring the clinical management of colorectal cancer by 18F-FDG PET/CT
Yang Shi, Meiqi Wang, Jiyu Zhang, Zheng Xiang, Can Li, Jingjing Zhang, Xing Ma
Frontiers in Oncology.2022;[Epub] CrossRef
Clinical TNM staging for esophageal, gastric, and colorectal cancers in the era of neoadjuvant therapy: A systematic review of the literature
Hideaki Shimada, Takeo Fukagawa, Yoshio Haga, Shin‐ichi Okazumi, Koji Oba
Annals of Gastroenterological Surgery.2021; 5(4): 404. CrossRef
The significant value of predicting prognosis in patients with colorectal cancer using 18F-FDG PET metabolic parameters of primary tumors and hematological parameters
Junyan Xu, Yi Li, Silong Hu, Linjun Lu, Zhiqi Gao, Huiyu Yuan
Annals of Nuclear Medicine.2019; 33(1): 32. CrossRef
Optimal Interval for 18F-FDG-PET After Chemoradiotherapy for Rectal Cancer
Kazushige Kawai, Hiroaki Nozawa, Keisuke Hata, Toshiaki Tanaka, Takeshi Nishikawa, Koji Oba, Toshiaki Watanabe
Clinical Colorectal Cancer.2018; 17(2): e163. CrossRef
Preoperative PET/CT 18F-FDG Standardized Uptake by Lymph Nodes as a Significant Prognostic Factor in Patients with Colorectal Cancer
Ruohua Chen, Yining Wang, Xiang Zhou, Gang Huang, Jianjun Liu
Contrast Media & Molecular Imaging.2018; 2018: 1. CrossRef

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The Usefulness of a Colonoscopy with Biopsy in the Early and Accurate Diagnosis of Ischemic Colitis: Eui Joong Kim, Soon Man Yoon, Sang Hwa Lee, Ki Bae Kim, Joo Young Lee, Dong-Hwa Lee, Eun Bee Kim, Soonyoung Park, Joung Ho Han, Hee Bok Chae, Seon Mee Park, Sei Jin Youn, Ro Hyun Sung; Intest Res 2013;11(2):100-106. Published online April 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.2.100

Abstract PDF

Background/Aims
Ischemic colitis has a clinical spectrum ranging from mild reversible colitis to an acute fulminant course. Early and accurate diagnosis is therefore mandatory for a good clinical outcome. The aim of this study is to evaluate the efficacy and safety of a colonoscopy and histological examination with biopsy in the early and accurate diagnosis of ischemic colitis. Methods: We investigated the clinical characteristics and endoscopic findings with the histopathology of 89 cases of ischemic colitis from October 2002 to August 2012 in a tertiary-care hospital. All patients underwent a colonoscopy with biopsy within a few days of the onset of symptoms, and the histological features from the biopsy specimens were reviewed. In addition, the occurrence of complications by colonoscopy with biopsy was evaluated. Results: The mean age of the patients was 65.8±12.6 years (male:female, 1:2.2). The major combined disorders were hypertension (51.7%), diabetes (31.5%), and arrhythmia (19.1%). The clinical features usually presented with hematochezia (83.1%), abdominal pain (77.5%), and diarrhea (60.7%). The involved patterns were the left colon (56.2%), right colon (39.3%), and pancolon (4.5%). Based on the main histological features of ischemic colitis, including glandular atrophy (67.4%), hemorrhage (61.8%), capillary thrombi (42.7%), and coagulative necrosis of mucosa (29.2%), 67 of the 89 cases (75.3%) could be confirmed with ischemic colitis. There were no serious complications such as bowel perforation or major bleeding following the colonoscopy with biopsy. Conclusions: A colonoscopy with biopsy is beneficial and safe for the early and precise diagnosis of ischemic colitis. (Intest Res 2013;11:100-106)

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What's the Clinical Features of Colitis in Elderly People in Long-Term Care Facilities?
So Yoon Yoon, Sung-Ae Jung, Sun-Kyung Na, Jae-In Ryu, Hye-Won Yun, Min-Jin Lee, Eun-Mi Song, Seong-Eun Kim, Hye-Kyung Jung, Ki-Nam Shim
Intestinal Research.2015; 13(2): 128. CrossRef
Author's Reply
Eui Joong Kim, Soon Man Yoon
Intestinal Research.2013; 11(3): 231. CrossRef
The Clinical Impact of Early Colonoscopic Biopsy in Ischemic Colitis
Young-Eun Joo
Intestinal Research.2013; 11(3): 229. CrossRef

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Clinical Observation after Resection of Lower Gastrointestinal Carcinoid Tumor: Ja Chung Goo, Byeong Uk Kim, Jee In Jeong, Joung-Ho Han, Hee Bok Chae, Seon Mee Park, Sei Jin Youn, Ho Chang Lee; Intest Res 2010;8(2):142-150. Published online December 30, 2010; DOI: https://doi.org/10.5217/ir.2010.8.2.142

Abstract PDF

Background/Aims
The increase of colonoscopy procedures has led to an increase in the diagnosis of carcinoid tumors in the lower gastrointestinal tract. The purpose of this study was to identify the clinical and pathological characteristics that affect the treatment and recurrence of carcinoid tumors of the lower gastrointestinal tract. Methods: A 10-year (1999-2009) retrospective analysis of 41 patients with carcinoid tumors of the lower gastrointestinal tract at the Chungbuk National University Hospital was conducted. Patient and tumor characteristics, treatment and recurrence were analyzed. Results: The mean age was 47.4±12.4 (range, 22-79 years) and the male to female ratio was 1:0.64. The mean tumor size was 9.4±4.8 (3-20) mm. In the lower gastrointestinal tract, the rectum was the most frequent location of the lower gastrointestinal carcinoid tumors (92.7%). Twenty-nine out of 41 patients were treated by endoscopy (mean size of tumor: 8.0±3.4 mm) and 12 were treated by surgery (mean size of tumor: 13.8±5.8 mm)(P=0.011). Among the patients treated by endoscopy, only one patient had a complete resection. However, the histology showed that 10 patients treated by endoscopy had positive resection margins; all 10 cases (35.7%) had a polypectomy (P=0.013). The mean follow-up duration was 19.2±14.5 months, and there were two recurrences of rectal carcinoid tumors. Conclusions: Both endoscopic and surgical resections were effective methods for the treatment of lower gastrointestinal carcinoid tumors. However, endoscopic polypectomy should be carefully considered because of the possibility of more frequent incomplete histological resections. Moreover, even for small rectal carcinoid tumors, follow-up examination should be performed to evaluate for tumor recurrence. (Intest Res 2010;8:142-150)

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Multiple Colonic Metastases from Hepatocellular Carcinoma
Gwi Hong Jeong, Byong Duk Ye, Seung Jae Myung
The Korean Journal of Gastroenterology.2011; 58(5): 288. CrossRef
Endoscopic Resection for Rectal Carcinoid Tumor: Efficacy and Clinical Results of Follow-up
Gwang Un Kim, Byong Duk Ye, Jeong-Sik Byeon, Hwan Sung Park, Tae Jin Ok, Dong-Hoon Yang, Kee Wook Jung, Kyung Jo Kim, Seung-Jae Myung, Suk-Kyun Yang, Jin-Ho Kim
Intestinal Research.2011; 9(3): 217. CrossRef

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The Effect of Autonomic Nerve System on Neurotensin Induced Motility in Isolated, Vascularly Perfused Rat Colon: Jeong Hoon Ji, Sung Moo Kim, Euikeun Seo, Young Shim Cho, Suk-Hee Yoo, Joung-Ho Han, Hee Bok Chae, Seon Mee Park, Sei Jin Youn; Intest Res 2010;8(2):162-171. Published online December 30, 2010; DOI: https://doi.org/10.5217/ir.2010.8.2.162

Abstract PDF: Background/Aims
Although neurotensin (NT) stimulates colon motility and the passage of intestinal contents, the associated mechanism of action remains unclear. The objective of this study was to investigate the effects of NT on colon motility using isolated rat colon. Methods: Intraluminal pressure was measured at both the proximal and distal portions of the isolated colon. An isolated rat colon was perfused with Krebs solution via the superior mesenteric artery. After stabilization, NT was administered in concentrations of 14, 28, 138 and 276 pM. After pretreatment with phentolamine, propranolol, hexamethonium, atropine or tetrodotoxin, NT was administered at a concentration of 276 pM, and then the intraluminal pressure was monitored. Results: NT significantly increased colon motility at concentrations of 14, 28, 138, and 276 in the proximal colon (25.1±6.5%, 175.4±117.0%, 240.8±115.1% and 252.3±110.6%, respectively) and in the distal colon (35.6±11.8%, 97.5±35.1%, 132.7±36.7% and 212.1±75.2%, respectively). The stimulant effect of NT was more potent in the proximal colon, in a concentration-dependent manner (P＜0.05). The stimulant effect of NT was significantly inhibited by atropine at both the proximal and distal colon and by tetrodotoxin at the proximal colon, but not by tetrodotoxin at the distal colon and not by propranolol, phentolamine, or hexamethonium at both the proximal and distal colon. Conclusions: NT increased colon motility at both the proximal and distal portions of the rat colon. The effects were more prominent at the proximal portion. The results of this study suggest that the stimulant action of NT may be mediated by local cholinergic muscarinic receptors. (Intest Res 2010;8:162-171)

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