- IBD
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The impact of clinical experience on decision-making regarding the treatment and management of mild-to-moderate ulcerative colitis
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Jae Hee Cheon, Kristine Paridaens, Sameer Al Awadhi, Jakob Begun, John R Fullarton, Edouard Louis, Fernando Magro, Juan Ricardo Marquez, Alexander R Moschen, Neeraj Narula, Grazyna Rydzewska, Axel U Dignass, Simon PL Travis
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Intest Res 2023;21(1):161-167. Published online April 18, 2022
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DOI: https://doi.org/10.5217/ir.2022.00006
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Citations
Citations to this article as recorded by  - New genetic biomarkers predicting 5-aminosalicylate-induced adverse events in patients with inflammatory bowel diseases
Jihye Park, I. Seul Park, Ji Hyung Kim, Jung Hyun Ji, Soo Jung Park, Jae Jun Park, Tae Il Kim, Seung Won Kim, Jae Hee Cheon
Therapeutic Advances in Gastroenterology.2024;[Epub] CrossRef
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- Inflammatory Bowel Diseases
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High mucosal cytomegalovirus DNA helps predict adverse short-term outcome in acute severe ulcerative colitis
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Saransh Jain, Divya Namdeo, Pabitra Sahu, Saurabh Kedia, Peush Sahni, Prasenjit Das, Raju Sharma, Vipin Gupta, Govind Makharia, Lalit Dar, Simon PL Travis, Vineet Ahuja
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Intest Res 2021;19(4):438-447. Published online November 6, 2020
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DOI: https://doi.org/10.5217/ir.2020.00055
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 Abstract
PDFSupplementary MaterialPubReaderePub
- Background/Aims
Predictors of short-term outcome of intravenous (IV) steroid therapy in acute severe ulcerative colitis (ASUC) have been well described, but the impact of cytomegalovirus (CMV) infection as a predictor of outcome remains debatable. We investigated the role of quantitative CMV polymerase chain reaction (PCR) as a predictor of short-term outcome in patients with ASUC.
Methods
Consecutive patients with ASUC satisfying Truelove and Witts criteria hospitalized at All India Institute of Medical Sciences (AIIMS) from May 2016 to July 2019 were included; all received IV steroid. The primary outcome measure was steroid-failure defined as the need for rescue therapy (with ciclosporin or infliximab) or colectomy during admission. AIIMS’ index (ulcerative colitis index of severity > 6 at day 1+fecal calprotectin > 1,000 μg/g at day 3), with quantitative CMV PCR on biopsy samples obtained at initial sigmoidoscopy were correlated with the primary outcome.
Results
Thirty of 76 patients (39%) failed IV corticosteroids and 12 (16%) underwent surgery. Patients with steroid failure had a significantly higher mucosal CMV DNA than responders (3,454 copies/mg [0–2,700,000] vs. 116 copies/mg [0–27,220]; P< 0.01). On multivariable analysis, mucosal CMV DNA load > 2,000 copies/mg (odds ratio [OR], 10.2; 95% confidence interval [CI], 2.6–39.7; P< 0.01) and AIIMS’ index (OR, 39.8; 95% CI, 4.4–364.4; P< 0.01) were independent predictors of steroid-failure and need for colectomy. The combination correctly predicted outcomes in 84% of patients with ASUC.
Conclusions
High mucosal CMV DNA ( > 2,000 copies/mg) independently predicts failure of IV corticosteroids and short-term risk of colectomy and it has an additional value to the established markers of disease severity in patients with ASUC.
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Citations
Citations to this article as recorded by - Epstein-Barr virus infection is an independent risk factor for surgery in patients with moderate-to-severe ulcerative colitis
Hui Zhang, Xi Gu, Wei He, Shu-Liang Zhao, Zhi-Jun Cao
World Journal of Gastroenterology.2025;[Epub] CrossRef - Systematic Review: Outcome Prediction in Acute Severe Ulcerative Colitis
Julia Angkeow, Alissa Rothman, Lara Chaaban, Nicole Paul, Joanna Melia
Gastro Hep Advances.2024; 3(2): 260. CrossRef - Predictors of adverse outcomes of steroids in patients with severe ulcerative colitis (systematic review and meta-analyses)
A. F. Mingazov, O. I. Sushkov, B. R. Kalanov, T. A. Baranova, S. I. Achkasov
Koloproktologia.2024; 23(1): 172. CrossRef - Predicting Outcome after Acute Severe Ulcerative Colitis: A Contemporary Review and Areas for Future Research
Sudheer Kumar Vuyyuru, Olga Maria Nardone, Vipul Jairath
Journal of Clinical Medicine.2024; 13(15): 4509. CrossRef - Low prevalence of Clostridioides difficile infection in acute severe ulcerative colitis: A retrospective cohort study from northern India
Sandeep Mundhra, David Thomas, Saransh Jain, Pabitra Sahu, Sudheer Vuyyuru, Peeyush Kumar, Bhaskar Kante, Rajesh Panwar, Peush Sahni, Rama Chaudhry, Prasenjit Das, Govind Makharia, Saurabh Kedia, Vineet Ahuja
Indian Journal of Gastroenterology.2023; 42(3): 411. CrossRef - The role of cytomegalovirus colitis on short- and long-term outcomes for patients with ulcerative colitis
Mengmeng Zhang, Xiaoyin Bai, Huimin Zhang, Yan You, Hong Lv, Yue Li, Bei Tan, Ji Li, Hui Xu, Weiyang Zheng, Hong Yang, Jiaming Qian
Scandinavian Journal of Gastroenterology.2022; 57(3): 282. CrossRef - Cytomegalovirus in ulcerative colitis: an evidence-based approach to diagnosis and treatment
Anuraag Jena, Shubhra Mishra, Anupam Kumar Singh, Aravind Sekar, Vishal Sharma
Expert Review of Gastroenterology & Hepatology.2022; 16(2): 109. CrossRef - Prospective validation of AIIMS index as a predictor of steroid failure in patients with acute severe ulcerative colitis
Pabitra Sahu, Saransh Jain, Saurabh Kedia, Sudheer K. Vuyyuru, Peush Sahni, Raju Sharma, Rajesh Panwar, Prasenjit Das, Vipin Gupta, Govind Makharia, Simon Travis, Vineet Ahuja
Indian Journal of Gastroenterology.2022; 41(3): 273. CrossRef - Cytomegalovirus Infection in Patients with Inflammatory Bowel Disease
Jun Lee
The Korean Journal of Gastroenterology.2022; 80(2): 60. CrossRef - The Impact of Human Herpesviruses in Clinical Practice of Inflammatory Bowel Disease in the Era of COVID-19
Shuhei Hosomi, Yu Nishida, Yasuhiro Fujiwara
Microorganisms.2021; 9(9): 1870. CrossRef - Does cytomegalovirus load predict the outcome of acute severe ulcerative colitis?
You Sun Kim
Intestinal Research.2021; 19(4): 357. CrossRef
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- IBD
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IBD2020 global forum: results of an international patient survey on quality of care
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Peter Irving, Johan Burisch, Richard Driscoll, Mats Olsson, John R Fullarton, Barry S Rodgers-Gray, Simon PL Travis
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Intest Res 2018;16(4):537-545. Published online October 10, 2018
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DOI: https://doi.org/10.5217/ir.2018.00041
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Abstract
PDFSupplementary MaterialPubReaderePub
- Background/Aims
IBD2020 is a global forum for standards of care in inflammatory bowel disease (IBD). The aim of the IBD2020 survey was to identify and describe variations in quality care of IBD.
Methods
Patients with IBD from Finland, Italy, France, Canada, Germany, UK, Spain and Sweden were surveyed during 2013 to 2014, covering: disease characteristics; impact on life and work; organization and perceived quality of care.
Results
Seven thousand five hundred and seven patients participated (median age, 39 years [range, 10–103 years]; 2,354 male [31.4%]), including 4,097 (54.6%) with Crohn’s disease (CD) and 3,410 (45.4%) with ulcerative colitis (UC). Median time from symptom onset to diagnosis was 1 year for both CD (range, 0–47 years) and UC (range, 0–46 years), with no clear evidence of improvement in diagnostic delay over the preceding 24 years. Half of the patients (3,429; 50.0%) rated their care as “excellent” or “very good,” with similar results for CD and UC across countries. Five factors were significantly (P<0.01) associated with perceived good quality of care: quality of specialist communication; review consultation being long enough; failure to share information; no access to a dietician; speed of advice.
Conclusions
The IBD2020 survey has highlighted areas related to quality of care of IBD from the patients’ perspective, with scope for improvement.
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Citations
Citations to this article as recorded by - Children and Young Adults With Inflammatory Bowel Disease Have an Increased Incidence and Risk of Developing Mental Health Conditions: A UK Population-Based Cohort Study
Rachel Cooney, Daniel Tang, Kevin Barrett, Richard K Russell
Inflammatory Bowel Diseases.2024; 30(8): 1264. CrossRef - Impact of mental health comorbidity in children and young adults with inflammatory bowel disease: a UK population-based cohort study
Rachel Cooney, Kevin Barrett, Richard K Russell
BMJ Open.2024; 14(2): e080408. CrossRef - Sources of diagnostic delay for people with Crohn’s disease and ulcerative colitis: Qualitative research study
Valérie Pittet
PLOS ONE.2024; 19(6): e0301672. CrossRef - Systematic review with meta‐analysis: Time to diagnosis and the impact of delayed diagnosis on clinical outcomes in inflammatory bowel disease
Nishani Jayasooriya, Samantha Baillie, Jonathan Blackwell, Alex Bottle, Irene Petersen, Hanna Creese, Sonia Saxena, Richard C. Pollok
Alimentary Pharmacology & Therapeutics.2023; 57(6): 635. CrossRef - Diagnostic delay in adult inflammatory bowel disease: A systematic review
Eleanor Cross, Benjamin Saunders, Adam D. Farmer, James A. Prior
Indian Journal of Gastroenterology.2023; 42(1): 40. CrossRef - The Experiences of Older Adults Living With Inflammatory Bowel Disease
Noelle Rohatinsky, Brooke Russell, Kevin B. Read
Gastroenterology Nursing.2023; 46(4): 296. CrossRef - Unmet Challenges in Patients with Crohn’s Disease
Katharina M Scheurlen, Mary A Parks, Anne Macleod, Susan Galandiuk
Journal of Clinical Medicine.2023; 12(17): 5595. CrossRef - The 2023 Impact of Inflammatory Bowel Disease in Canada: Access to and Models of Care
Holly Mathias, Noelle Rohatinsky, Sanjay K Murthy, Kerri Novak, M Ellen Kuenzig, Geoffrey C Nguyen, Sharyle Fowler, Eric I Benchimol, Stephanie Coward, Gilaad G Kaplan, Joseph W Windsor, Charles N Bernstein, Laura E Targownik, Juan-Nicolás Peña-Sánchez, K
Journal of the Canadian Association of Gastroenterology.2023; 6(Supplement): S111. CrossRef - Inflammatory bowel diseases: Transformation of representations. A review
Igor V. Maev, Igor G. Bakulin, Maria I. Skalinskaya, Ekaterina V. Skazyvaeva
Terapevticheskii arkhiv.2023; 95(12): 1064. CrossRef - Early Diagnosis, Early Stratification, and Early Intervention to Deliver Precision Medicine in IBD
Nurulamin M Noor, Paula Sousa, Stéphane Paul, Xavier Roblin
Inflammatory Bowel Diseases.2022; 28(8): 1254. CrossRef - Multinational evaluation of clinical decision-making in the treatment and management of mild-to-moderate ulcerative colitis
Axel U. Dignass, Kristine Paridaens, Sameer Al Awadhi, Jakob Begun, Jae Hee Cheon, John R. Fullarton, Edouard Louis, Fernando Magro, Juan Ricardo Marquez, Alexander R. Moschen, Neeraj Narula, Grazyna Rydzewska, Simon P. L. Travis
Scandinavian Journal of Gastroenterology.2022; 57(4): 424. CrossRef - Inflammatory bowel disease patient‐reported quality assessment should drive service improvement: a national survey of UK IBD units and patients
A. Barney Hawthorne, Jackie Glatter, Jonathan Blackwell, Rachel Ainley, Ian Arnott, Kevin J. Barrett, Graham Bell, Matthew J. Brookes, Melissa Fletcher, Rafeeq Muhammed, Alan M. Nevill, Jonathan Segal, Christian P. Selinger, Anja St. Clair Jones, Lisa You
Alimentary Pharmacology & Therapeutics.2022; 56(4): 625. CrossRef - Multicriteria Decision Analysis for Updating of Quality Indicators for Inflammatory Bowel Disease Comprehensive Care Units in Spain
Xavier Calvet, Julián Panés, Javier Gallardo-Escudero, Alberto de la Cuadra-Grande, Elena Bartolomé, Laura Marín, Fernando de la Portilla, Ester Navarro-Correal, Ana Gutiérrez, Pilar Nos, Ruth Serrano, Miguel Ángel Casado, Manuel Barreiro-de Acosta, Pilar
Journal of Crohn's and Colitis.2022; 16(11): 1663. CrossRef - Patient-reported Outcomes: the ICHOM Standard Set for Inflammatory Bowel Disease in Real-life Practice Helps Quantify Deficits in Current Care
Darren Wong, Lawrence Matini, Andrey Kormilitzin, Ramona Kantschuster, Daniel Martin Simadibrata, Sara Lyden, Jean Wilson, Oliver A Brain, Rebecca Palmer, Tim Ambrose, Jack Satsangi, Matthew South, John Geddes, Keith Bodger, Simon P L Travis, Alissa Walsh
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Debora Mayumi Takamune, Giovana Signorelli Astolfi Cury, Giulia Ferrás, Giedre Soares Prates Herrerias, Adriana Rivera, Jaqueline Ribeiro Barros, Julio Pinheiro Baima, Rogerio Saad-Hossne, Ligia Yukie Sassaki
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David T Rubin, Ailsa Hart, Remo Panaccione, Alessandro Armuzzi, Ulla Suvanto, J Jasper Deuring, John Woolcott, Joseph C Cappelleri, Kathy Steinberg, Laura Wingate, Stefan Schreiber
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Gionata Fiorino, Silvio Danese
United European Gastroenterology Journal.2021; 9(7): 745. CrossRef - Consensus standards of healthcare for adults and children with inflammatory bowel disease in the UK
Rukshana Kapasi, Jackie Glatter, Christopher A Lamb, Austin G Acheson, Charles Andrews, Ian D Arnott, Kevin J Barrett, Graham Bell, Guaraang Bhatnagar, Stuart Bloom, Matthew James Brookes, Steven R Brown, Nicola Burch, Andy Burman, Kay Crook, JR Fraser Cu
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Jordi Guardiola, Laura Marín, Javier P. Gisbert, Fernando Gomollón, Jordi Cohen, Carmen Conde
Economía de la Salud.2019;[Epub] CrossRef
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