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Inter-Physician Variation in Treatment for Patients with Crohn's Disease
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Hwang Choi, Sang Woo Kim, Kang Moon Lee, Bo In Lee, Dae Young Cheung, Min Kuk Kim, Hyun Jung Jung, Hyung Keun Kim, Jeong Seon Ji, Soo Heon Park, Hiun Suk Chae, Myung Gyu Choi, Kyu Yong Choi, In Sik Chung
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Intest Res 2009;7(1):41-46. Published online June 30, 2009
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- Background/Aims
The incidence and prevalence of Crohn's disease are increasing in Korea. However, the guidelines for the management of Crohn's disease have not been established in Korea. In the current study we determined the difference in the treatment methods between physicians in Korea for Crohn's disease. Methods: We retrospectively analyzed the use of medical and surgical treatment modalities in 92 patients with newly diagnosed Crohn's disease. We compared the treatment strategies among 4 physicians at 3 different institutions. Results: Prednisone, 5-aminosalicylates, antibiotics, immunomodulators, infliximab, and surgery were prescribed or preformed in 64%, 92%, 24%, 35%, 9%, and 22% of the patients, respectively. The surgical procedures included 12 bowel resections and 8 fistulectomies. The prescription rates for 5-aminosalicylates, prednisone, antibiotics, and infliximab did not differ, but of the use of immunomodulators was significantly different between physicians (p=0.012). The mean interval between diagnosis and the start of immunomodulators was 14 months, and was not different between physicians. The median dosage of immunomodulators was 50 mg per day, and was not different between physicians. Conclusions: A difference in medical treatment strategies for Crohn's disease between physicians exists in Korea. Specifically, there was a significant difference in the use of immunodulators between physicians. The development of treatment guidelines for Crohn's disease, together with efforts to decrease the inter-physician difference for treating Crohn's disease are needed. (Intest Res 2009;7:41-46)
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Endoscopic Differentiation of Small Bowel Strictures
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Hwang Choi, Kyu Yong Choi, Bo In Lee, Min Kuk Kim, Hyun Jung Jung, Jeong Seon Ji, Tae Ho Kim, Jung Hwan Oh, Kang Moon Lee, Sang Woo Kim, Soo Heon Park, Hiun Suk Chae, Myung Gyu Choi, Sok Won Han, In Sik Chung
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Intest Res 2007;5(1):38-44. Published online June 30, 2007
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Abstract
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- Background/Aims
The diagnosis of small bowel stricture was made by operation. Capsule endoscopy has been useful for diagnosis of small bowel diseases but has limited value in cases with stricture. Double balloon endoscopy is the useful method to visualize the entire small bowel. The aims of this study are to evaluate the feasibility of double balloon endoscopy and to differentiate the endoscopic findings in patients with small bowel stricture. Methods: Between March 2004 and February 2007, fifteen consecutive patients were referred for the evaluation of small bowel stricture. Small bowel strictures were suspected in small bowel series and CT in eleven patients. Capsule endoscopies were performed in six patients and entrapped in three patients. Double balloon endoscopy (EN-450P5/20, Fujinon, Japan) was performed with midazolam (median 5 mg, range 5-10 mg) and meperidine (median 50 mg, range 50-100 mg). All lesions except one were found within 60 minutes. One patient had been excluded because of false-positive finding of capsule endoscopy. Clinical and endoscopic findings were compared between strictures of Crohn's disease (group I, n=6) and those of other causes (group II, n=8). Results: Double balloon endoscpies were performed with good tolerance without side effect. Age, chief complaints, duration of symptom, and initial hemoglobin and serum albumin levels were not different between two groups. The proportion of male sex was higher in group I than group II (100%, 38%, respectively; p=0.031). The strictures below 0.5 cm in diameter were 83% in group I and 13% in group II (p=0.026). The arrangement of stricture in group I was more eccentric than that in group II (100%, 17%, respectively; p=0.015). The location of stricture, appearance of surrounding mucosa, associated ulcer, and ulcer margin were not different between two groups. Conclusions: Endoscopic differentiation using double balloon endoscopy can be made easily and safely in patients with small bowel stricture. The strictures of small bowel in patients with Crohn's disease were narrower and more eccentric than those in patients with other diseases. (Intest Res 2007;5:38-44)
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A Case of Bacterial Overgrowth Syndrome Presenting Recurrent Edema and Hypoproteinemia After Billoth II Operation
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Bo In Lee, Kyu Yong Choi, Byung Wook Kim, Hwang Choi, Se Hyun Cho, Woo Chul Chung, Kang Moon Lee, Soo Heon Park, Hyun Suk Chae, Myung Gyu Choi, In Sik Jung
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Intest Res 2003;1(2):197-200. Published online November 27, 2003
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- Recently, we experienced a case of bacterial overgrowth syndrome with recurrent edema, hypoproteinemia and normal serum cobalamine level after Billoth II subtotal gastrectomy, which was diagnosed by jejunal aspirates culture and antibiotics treatment. When predisposition and clinical suspicion were present, jejunal culture might be preferable especially in case of post-Billoth II operation status because jejunal approach is easy, screening tests are negative in certain cases and some screening tests are not available in Korea. (Intestinal Research 2003;2:197-200)
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Rapid Growth of Early Colorectal Cancer in a Short Period: a Case Report
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Bo In Lee, Kyu Yong Choi, Byung Wook Kim, Hwang Choi, Se Hyun Cho Cho, Woo Chul Chung Chung, Kang Moon Lee, Soo Heon Park, Hyun Suk Chae, Myung Gyu Choi, In Sik Jung
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Intest Res 2003;1(1):64-67. Published online May 27, 2003
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- Retrospective studies report that doubling time of early colorectal cancer is 26 months. Recently we experienced a case of early colorectal cancer which increased over twofold in a size in only 13 days. (Intestinal Research 2003;1:64-67)
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