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The Usefulness of F18-FDG PET/CT in Detection of Colonic Neoplasm
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Min Kyung Kang, Sung Pyo Hong, Ji Eun Lee, Tae Joo Jeon, Jong Woo Kim, Chang Il Kwon, Kwang Hyun Ko, Seong Gyu Hwang, Pil Won Park, Kyu Sung Rim
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Intest Res 2010;8(1):18-23. Published online June 30, 2010
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DOI: https://doi.org/10.5217/ir.2010.8.1.18
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 Abstract
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The diagnostic value of 2-18F-fluoro-2-deoxy-D-glucose positron emi-ssion to-mo--graphy (FDG PET)/CT in the detection of colon carcinoma and adenoma was evaluated retrospectively. Methods: Between May 2007 and June 2008, 102 patients (42 males and 60 females: age range, 28-89 years) underwent both FDG PET/CT and colonoscopy in < a 3 month interval. FDG uptake on PET/CT was divided into physiologic and pathologic uptake by a nuclear medicine specialist. Pathologic confirmation was obtained in all patients. Results: Forty-three patients had no abnormal findings on both FDG PET/CT and colonoscopy. One hundred five and 59 colonic lesions were detected on FDG PET/CT and colonoscopy, respectively. Eleven of 24 lesions with pathologic FDG uptake were histologically-confirmed to be malignancies. Among 18 lesions with physiologic FDG uptake, 1 carcinoma and 1 adenoma were revealed. One carcinoma, 25 adenomas, and 11 hyperplastic polyps did not reveal FDG uptake. Interpretation of pathologic FDG uptake in the colon had a sensitivity of 84.6% and 28.2%, a specificity of 90.4% and 88.1%, a positive predictive value of 45.8% and 45.8%, and a negative predictive value of 98.4% and 77.8% for carcinomas and adenomas, respectively. Conclusions: FDG PET/CT is a very useful diagnostic method for the detection of colon cancer, but the sensitivity is low for adenomas, which may need further evaluation, such as a screening endoscopy. (Intest Res 2010;8:18-23)
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Citations
Citations to this article as recorded by  - Is It Useful to Perform Additional Colonoscopy to Detect Unmatched Lesion between Positron Emission Tomography/Computed Tomography and Colonoscopy?
Chang Yong Yun, Jun-Oh Jung, Seong O Suh, Ji Won Yoo, Yu Mi Oh, Soo Min Ahn, Hyoung Hun Sim, Eun Sil Kim, Ji Yoon Bae
The Korean Journal of Gastroenterology.2013; 61(6): 319. CrossRef - Benign Colonic18F-FDG Uptake on Whole-Body FDG-PET Scan
Byung Ik Jang
Clinical Endoscopy.2012; 45(2): 109. CrossRef - The Role of F18-FDG PET/CT in Colorectal Neoplasm
Kyung-Jo Kim
Intestinal Research.2010; 8(1): 84. CrossRef
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