- Functional bowel disorder
-
Proinflammatory cytokines in irritable bowel syndrome: a comparison with inflammatory bowel disease
-
Antigony Mitselou, Vasileios Grammeniatis, Anna Varouktsi, Stamatis S Papadatos, Konstantinos Katsanos, Vasiliki Galani
-
Intest Res 2020;18(1):115-120. Published online January 30, 2020
-
DOI: https://doi.org/10.5217/ir.2019.00125
-
-
 Abstract
 PDF PubReader ePub
- Background/Aims
Irritable bowel syndrome (IBS) is a common disease often considered as a functional intestinal disorder. Inflammation in IBS is a quite intriguing theory. The aim of this study was to investigate tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 expression in inflammatory bowel disease (IBD) patients, IBS patients and normal controls.
Methods
IBS and IBD patients along with normal controls were recruited in the study. In all groups, 2 pinch biopsies were taken at each of 3 anatomical sites (terminal ileum, cecum, and rectum). IBS patients were also subcategorized according to the syndrome clinical manifestations. Two monoclonal antibodies (mAb), TNF-α mAb and IL-6 mAb, and one polyclonal antibody IL-1β mAb were applied for immunohistochemical analysis.
Results
In IBD patients intensity of TNF-α and IL-1β were lower than in IBS patients or controls, while IL-6 was significantly increased comparing to the aforementioned groups. In IBS patients TNF-α was increased comparing to IBD patients or controls, while IL-6 and IL-1β were similar to controls. In IBS subgroups, TNF-α was lower in diarrhea predominant IBS patients and higher constipation predominant IBS patients. Differences among IBS subgroups regarding IL-6 and IL-1β were nonsignificant.
Conclusions
IL-6 seems to be the most important proinflammatory cytokine in IBD patients, while TNF-α could play a more significant role in IBS pathogenesis.
-
Citations
Citations to this article as recorded by  - Guardians at the Gate: Immune System in Gastrointestinal Diseases
Elena Layunta, Jose Emilio Mesonero, Eva Latorre
International Journal of Molecular Sciences.2024; 25(11): 5933. CrossRef - Novel Dairy Fermentates Have Differential Effects on Key Immune Responses Associated with Viral Immunity and Inflammation in Dendritic Cells
Dearbhla Finnegan, Claire Connolly, Monica A. Mechoud, Jamie A. FitzGerald, Tom Beresford, Harsh Mathur, Lorraine Brennan, Paul D. Cotter, Christine E. Loscher
Foods.2024; 13(15): 2392. CrossRef - The Latest Data Concerning the Etiology and Pathogenesis of Irritable Bowel Syndrome
Vlad Alexandru Ionescu, Gina Gheorghe, Teodor Florin Georgescu, Nicolae Bacalbasa, Florentina Gheorghe, Camelia Cristina Diaconu
Journal of Clinical Medicine.2024; 13(17): 5124. CrossRef - Morphological Changes of the Pituitary Gland in Patients with Irritable Bowel Syndrome Using Magnetic Resonance Imaging
Jessica Abou Chaaya, Jennifer Abou Chaaya, Batoul Jaafar, Lea Saab, Jad Abou Chaaya, Elie Al Ahmar, Elias Estephan
Journal of Imaging.2024; 10(9): 226. CrossRef - Review article: The role of the gut–brain axis in inflammatory bowel disease and its therapeutic implications
Christy Riggott, Alexander C. Ford, David J. Gracie
Alimentary Pharmacology & Therapeutics.2024; 60(9): 1200. CrossRef - Novel hypothesis and therapeutic interventions for irritable bowel syndrome: interplay between metal dyshomeostasis, gastrointestinal dysfunction, and neuropsychiatric symptoms
Yutaka Nakagawa, Shizuo Yamada
Molecular and Cellular Biochemistry.2024;[Epub] CrossRef - Unraveling the intricacies of neutrophil extracellular traps in inflammatory bowel disease: Pathways, biomarkers, and promising therapies
Yilin Wu, Jun Shen
Cytokine & Growth Factor Reviews.2024; 80: 156. CrossRef - Transcriptional Responses of Lacticaseibacillus rhamnosus to TNFα, IL-6, IL-8, and IL-10 Cytokines
Ksenia M. Klimina, Marina S. Dyachkova, Vladimir A. Veselovsky, Natalia V. Zakharevich, Aleksandra A. Strokach, Oksana V. Selezneva, Egor A. Shitikov, Dmitry A. Bespiatykh, Roman A. Yunes, Elena U. Poluektova, Maya V. Odorskaya, Polina S. Ostroukhova, Ser
Biology.2024; 13(11): 931. CrossRef - Evaluation of two laboratory model methods for diarrheal irritable bowel syndrome
Qian Chen, Hua Zhang, Chang-Yue Sun, Qing-Ying He, Rui-Rong Zhang, Bin-Fei Luo, Zi-Hao Zhou, Xiao-Fan Chen
Molecular Medicine.2023;[Epub] CrossRef - Structural properties and anti-inflammatory activity of purified polysaccharides from Hen-of-the-woods mushrooms (Grifola frondosa)
Xiaoyi Liu, Shuai Chen, Huijuan Liu, Jiao Xie, K. M. Faridul Hasan, Qibing Zeng, Shaofeng Wei, Peng Luo
Frontiers in Nutrition.2023;[Epub] CrossRef - An Asian perspective on irritable bowel syndrome
Kee Wook Jung, Seung-Jae Myung
Intestinal Research.2023; 21(2): 189. CrossRef - Molecular Mechanisms of the Antitumor Effects of Mesalazine and Its Preventive Potential in Colorectal Cancer
Joanna Słoka, Marcel Madej, Barbara Strzalka-Mrozik
Molecules.2023; 28(13): 5081. CrossRef - Structure and Metabolic Activity of the Gut Microbiota in Diarrhea-Predominant Irritable Bowel Syndrome Combined with Functional Dyspepsia
Aleksandra Kovaleva, Elena Poluektova, Roman Maslennikov, Oxana Zolnikova, Oleg Shifrin, Anna Kudryavtseva, George Krasnov, Maria Fedorova, Anna Karchevskaya, Vladimir Ivashkin
Gastrointestinal Disorders.2023; 5(3): 296. CrossRef - NK cells vs. obesity: A tale of dysfunction & redemption
Conor De Barra, Donal O'Shea, Andrew E. Hogan
Clinical Immunology.2023; 255: 109744. CrossRef - Non-invasive neuromodulation: an emerging intervention for visceral pain in gastrointestinal disorders
Md Jahangir Alam, Jiande D. Z. Chen
Bioelectronic Medicine.2023;[Epub] CrossRef - Gut–Brain Axis, Microbiota and Probiotics—Current Knowledge on Their Role in Irritable Bowel Syndrome: A Review
Cristina Maria Marginean, Mihaela Popescu, Andrei Ioan Drocas, Sergiu Marian Cazacu, Radu Mitrut, Iulia Cristina Marginean, George Alexandru Iacob, Marian Sorin Popescu, Anca Oana Docea, Paul Mitrut
Gastrointestinal Disorders.2023; 5(4): 517. CrossRef - Comparative treatment of Sulfasalazine+Ezetimibe combination and Sulfasalazine in a rat model with induced colitis
Farrah Rasool Jaafar, Ahmed Abu-Raghif
Journal of Medicine and Life.2023; 16(8): 1165. CrossRef - Screening and Evaluation of Probiotics for Reducing Intestinal Inflammation
雅君 陈
Hans Journal of Food and Nutrition Science.2022; 11(01): 44. CrossRef - Protection against ulcerative colitis and colorectal cancer by evodiamine via anti‑inflammatory effects
Yongfeng Zhang, Yaqin Zhang, Yang Zhao, Wanyue Wu, Weiqi Meng, Yulin Zhou, Ye Qiu, Chenliang Li
Molecular Medicine Reports.2022;[Epub] CrossRef - The Role of Neuro-Immune Interaction in Chronic Pain Conditions; Functional Somatic Syndrome, Neurogenic Inflammation, and Peripheral Neuropathy
Elaine Meade, Mary Garvey
International Journal of Molecular Sciences.2022; 23(15): 8574. CrossRef - Ameliorating effects of electroacupuncture on the low‐grade intestinal inflammation in rat model of diarrhea‐predominant irritable bowel syndrome
Xuemei Li, Kuiyu Ren, Xiaojuan Hong, Sha Guo, Shuguang Yu, Sha Yang
Journal of Gastroenterology and Hepatology.2022; 37(10): 1963. CrossRef - Healthy Sleep Every Day Keeps the Doctor Away
Cailan Lindsay Feingold, Abbas Smiley
International Journal of Environmental Research and Public Health.2022; 19(17): 10740. CrossRef - Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Trial
Seung Yong Shin, Sein Park, Jung Min Moon, Kisung Kim, Jeong Wook Kim, Jongsik Chun, Tae Hee Lee, Chang Hwan Choi
Journal of Neurogastroenterology and Motility.2022; 28(4): 642. CrossRef - Overlap of Functional Gastrointestinal Disorders: Common Mechanisms of Pathogenesis as a Key to Rational Therapy
S. N. Mekhdiyev, O. A. Mekhdieva, O. M. Berko
Russian Journal of Gastroenterology, Hepatology, Coloproctology.2022; 32(4): 95. CrossRef - Effect of Heat-Killed Lactobacillus casei DKGF7 on a Rat Model of Irritable Bowel Syndrome
Gyeol Seong, Seungbaek Lee, Yang Won Min, Yeon Sil Jang, Hong Seog Kim, Eui-Joong Kim, So-Young Park, Cheol-Hyun Kim, Dong Kyung Chang
Nutrients.2021; 13(2): 568. CrossRef - A Comprehensive Review: Sphingolipid Metabolism and Implications of Disruption in Sphingolipid Homeostasis
Brianna M. Quinville, Natalie M. Deschenes, Alex E. Ryckman, Jagdeep S. Walia
International Journal of Molecular Sciences.2021; 22(11): 5793. CrossRef - Lactiplantibacillus plantarum 299v (LP299V®): three decades of research
E. Arvidsson Nordström, C. Teixeira, C. Montelius, B. Jeppsson, N. Larsson
Beneficial Microbes.2021; 12(5): 441. CrossRef - Immunohistochemical Study of Adhesion Molecules in Irritable Bowel Syndrome
Antigony Mitselou, Vasileios Grammeniatis, Anna Varouktsi, Stamatis S. Papadatos, Antonios Klaroudas, Konstantinos Katsanos, Vasiliki Galani
Advanced Biomedical Research.2021; 10(1): 21. CrossRef - TNF-α, IL-17, and IL-22 production in the rectal mucosa of nonceliac wheat sensitivity patients: role of adaptive immunity
Pasquale Mansueto, Diana Di Liberto, Francesca Fayer, Maurizio Soresi, Girolamo Geraci, Antonio Giulio Giannone, Aurelio Seidita, Alberto D’Alcamo, Francesco La Blasca, Marianna Lo Pizzo, Ada Maria Florena, Francesco Dieli, Antonio Carroccio
American Journal of Physiology-Gastrointestinal and Liver Physiology.2020; 319(3): G281. CrossRef - Sudachinoid- and Ichangensin-Type Limonoids from Citrus junos Downregulate Pro-Inflammatory Cytokines
Jihun Shin, Hwa Young Song, Mina Lee
International Journal of Molecular Sciences.2020; 21(18): 6963. CrossRef - Differential clusterization of soluble and extracellular vesicle-associated cytokines in myocardial infarction
Anna Lebedeva, Wendy Fitzgerald, Ivan Molodtsov, Alexander Shpektor, Elena Vasilieva, Leonid Margolis
Scientific Reports.2020;[Epub] CrossRef - Lactoferrin in the Prevention and Treatment of Intestinal Inflammatory Pathologies Associated with Colorectal Cancer Development
Antimo Cutone, Giusi Ianiro, Maria Stefania Lepanto, Luigi Rosa, Piera Valenti, Maria Carmela Bonaccorsi di Patti, Giovanni Musci
Cancers.2020; 12(12): 3806. CrossRef
-
6,904
View
-
193
Download
-
30
Web of Science
-
32
Crossref
|
KASID
