Intestinal Research

Yong Cheol Jeon

8 Articles

A Case of Adenocarcinoma of the Transverse Colon with Humoral Hypercalcemia of Malignancy: Jae Gon Lee, Dong Soo Han, Jae Ha Kim, You Shin Kim, Hyun Soo Kim, Jae Yoon Jeong, Ju Yeon Pyo, Yong Cheol Jeon, Joo Hyun Sohn; Intest Res 2012;10(4):397-399. Published online October 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.4.397

Hypercalcemia is a common electrolyte imbalance in patients with malignancy. Approximately 80% of hypercalcemia is associated with humoral hypercalcemia of malignancy (HHM), but occurs rarely in colorectal carcinomas. A 72-year-old man was admitted with abdominal pain and bowel habit change. Colonoscopy showed a malignant tumor in the transverse colon. Laboratory data showed an elevated serum calcium level (11.6 mg/dL) and elevated parathyroid hormone-related peptide level (12.2 pmol/L). Histology showed poorly differentiated adenocarcinoma. We infused intravenous normal saline, furosemide and pamidronate. The serum calcium level was subsequently normalized. However, the patient died from cancer progression 10 days later. With a review of the relevant literature, we report a case of adenocarcinoma of the transverse colon with HHM. (Intest Res 2012;10:397-399)

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Esophageal Cancer Initially Presenting as Severe Paraneoplastic Hypercalcemia Requiring Hemodialysis
Hye Shin Ahn, Jong Min Yun, Yeong Bok Lee, Yu Mi Ko, Jung Eun Lee, Hye Sung Won, Sung Soo Kim, Young Ok Kim
The Korean Journal of Gastroenterology.2015; 65(6): 361. CrossRef

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A Case of Acquired Zonal Aganglionosis in Adult: Woong Jun Kim, Chang Soo Eun, Min Kyu Lee, Seung Yeon Min, Yeon Hwa Yoo, Dong Soo Han, Yong Cheol Jeon, Joo Hyun Sohn; Intest Res 2012;10(2):210-214. Published online April 30, 2012; DOI: https://doi.org/10.5217/ir.2012.10.2.210

Abstract PDF: A chronic intestinal pseudo-obstruction is a rare disorder and a severe digestive syndrome. It is characterized by deranged gut propulsive motility that resembles a mechanical obstruction, but no obstructive process is present. An intestinal pseudo-obstruction may be classified as acute or chronic; the chronic form may also be classified as idiopathic or secondary to a variety of diseases. Treatment of intestinal pseudo-obstruction involves nutritional, pharmacological, and surgical therapies. Surgery should be limited to patients who are refractory to medical therapy and show a deteriorating course. Despite available medical and surgical interventions, the outcome remains poor. Here, we describe a case of a 54-year-old female with chronic constipation and abdominal distension, who was subsequently found to have segmental aganglionosis. The patient was treated with a subtotal colectomy and ileosigmoidostomy without sequelae. (Intest Res 2012;10: 0-214)

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A Case of Methicillin-Resistant Staphylococcal Enterocolitis with Subsequent Development of Lymphocytic Colitis: Joong Ho Bae, Dong Soo Han, Hye Sun Park, Yil Sik Hyun, Tae Yeob Kim, Chang Soo Eun, Yong Cheol Jeon, Joo Hyun Sohn; Intest Res 2011;9(2):139-143. Published online August 30, 2011; DOI: https://doi.org/10.5217/ir.2011.9.2.139

Abstract PDF: Staphylococcus aureus (S. aureus) is occasionally a normal inhabitant of the gastrointestinal tract, and rarely considered a cause of enterocolitis. Methicillin-resistant Staphylococcal enterocolitis may cause persistent diarrhea leading to severe complications and even death, without appropriate treatment. Lymphocytic colitis (LC), a subtype of microscopic colitis, is a relatively common cause of chronic watery diarrhea. We report the case of a 73-year-old woman with profuse watery diarrhea caused by methicillin-resistant S. aureus. Soon after treatment of her enterocolitis with vancomycin the patient's general condition and symptoms improved, although the diarrhea persisted. Through colonoscopic biopsy and immunohistochemical staining, overt LC was diagnosed, and prompt therapy with budesonide was initiated. (Intest Res 2011;9:139-143)

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A Case of Warfarin-Induced Intramural Hematoma Diagnosed by Double-Balloon Enteroscopy: Dong Hwi Rim, Chang Soo Eun, Shin Jae Moon, Jung Ho Bae, Tae Yeob Kim, Hang Lak Lee, Joo Hyun Sohn, Yong Cheol Jeon, Dong Soo Han; Intest Res 2011;9(2):162-165. Published online August 30, 2011; DOI: https://doi.org/10.5217/ir.2011.9.2.162

Abstract PDF: Although bleeding is a major complication of oral anticoagulant therapy, warfarin-induced spontaneous intramural hematoma of the small bowel is a very rare complication. The clinical features of spontaneous intramural hematoma vary from mild abdominal pain to panperitonitis due to bowel perforation. Because spontaneous intramural hematoma can proceed to a life threatening situation, early diagnosis is of vital importance. Although there are a number of radiologic diagnostic tools available including abdominal ultrasonography and computed tomography, confirmation of the diagnosis through direct visualization of the involved bowel mucosa is very helpful. Direct confirmation of warfarin-induced spontaneous intramural hematoma of the small bowel is possible using double-balloon enteroscopy. We report a case of warfarin-induced spontaneous intramural hematoma with a review of the relevant literature. (Intest Res 2011;9:162-165)

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Postinfectious Irritable Bowel Syndrome after Clostridium difficile Infection: Hye Sun Park, Dong Soo Han, Yil Sik Hyun, Joong Ho Bae, Sang Bong Ahn, Hyun Seok Cho, Tae Yeob Kim, Chang Soo Eun, Yong Cheol Jeon, Joo Hyun Sohn; Intest Res 2009;7(2):100-104. Published online December 30, 2009

Abstract PDF: Background/Aims
Post-infectious irritable bowel syndrome (PI-IBS) frequently follows bacterial enterocolitis, and there are various reported incidences and clinical courses according to different pathogens. However, there have rarely been any reports regarding the PI-IBS caused by Clostridium difficile infection (CDI). The aims of this study were to evaluate the incidence and the risk factors for developing IBS following CDI. Methods: We recruited 86 patients with CDI from January 2005 to October 2007 and also we recruited a comparative control group of 86 patients who had no previous history of any gastroenterological disease. The bowel symptoms were prospectively evaluated by phone through a set questionnaire. Results: Of all the CDI patients, a total of 41 patients (47.6%) completed the questionnaires, and IBS developed in 8 patients (19.5%), of which 7 patients (87.5%) were the diarrhea type. A total of 51 patients (59.3%) from the control group completed the questionnaires, of which 4 patients (7.8%) developed IBS. Although there was no statistically significant difference (p=0.099), there was a tendency towards a higher incidence of developing IBS in the CDI patients group, as compared to that of the control group. Comparing the group that developed IBS with the group that didn't among the CDI patients, there were no significantly different factors except for a previous admission history before CDI. Conclusions: The incidence of PI-IBS after CDI was 19.5%, and the IBS was predominantly the diarrhea-type. In the future, a large scale study needs to be conducted in order to evaluate the PI-IBS incidence after CDI and the risk factors that predispose patients to such conditions. (Intest Res 2009;7:100-104)

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Clinical Features of Intestinal Behcet's Disease according to Disease Subtypes: Ji Eun Kim, Dong Soo Han, Hyun Seok Cho, Tae Joon Byun, Tae Yeob Kim, Chang Soo Eun, Yong Cheol Jeon, Joo Hyun Sohn; Intest Res 2007;5(1):26-32. Published online June 30, 2007

Abstract PDF: Background/Aims
Intestinal Behcet's disease can be diagnosed when Behcet's disease patient has intestinal ulcers. The aim of this study was to recognize the clinical features and course of intestinal Behcet's disease according to disease subtypes. Methods: We performed a retrospective chart review of patients who had intestinal lesions associated with Behcet's disease on colonoscopy between March, 2001 and May, 2006. Results: Of the 38 patients (18 men/20 women) enrolled, the mean age at diagnosis was 40.9⁑13.6 years. By Japanese criteria, 18 patients were classified in incomplete type, 8 in suspected type, and 8 in possible type. Four patients had only intestinal lesion without Behcet's manifestation. By International Study Group of Behcet's Disease criteria, 10 were met Behcet's disease, and 15 was suspected as Behcet's disease. Characteristics of intestinal ulcers were aphthous shape and ileocecal location. Five patients were reclassified during clinical course. There was no difference at clinical outcome according to prescribed medications. Conclusions: Not a few of intestinal Behcet's disease patients were difficult to meet the Behcet's disease criteria. Because clinical manifestations of intestinal Behcet's disease patients may be changed, it would be needed to reclassify disease subtypes with long-term follow-up. (Intest Res 2007;5:26-32)

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A Case of Multiple Deep Infiltrating Intestinal Endometriosis Presenting as Abdominal Mass: Hyun Seok Cho, Dong Soo Han, Se Woo Park, Tae Jun Byun, Tae Yeob Kim, Chang Soo Eun, Yong Cheol Jeon, Joo Hyun Sohn; Intest Res 2007;5(1):87-91. Published online June 30, 2007

Abstract PDF: Endometriosis is one of the most common benign gynecologic conditions in women of childbearing age. Endometriosis involving the gastrointestinal tract occurs in 5.3-12% of women and the most commonly affected site is the rectum and the sigmoid colon. The reports of intestinal endometriosis in Korea are too few to obtain a rate of occurence, and in these cases, the depth of invasion was limited to the serosa, resulting in no significant symptoms or signs. Intestinal endometriosis can show up as a mass suggestive of malignant neoplasm on imaging studies, which can result in serious errors in diagnosis and treatment. In Korean studies, the masses were solitary, and there was no reported case of multiple endometriosis in the sigmoid colon, ascending and descending colon. We report a case of multiple deep infiltrating intestinal endometriosis presenting as an abdominal mass. (Intest Res 2007;5:87-91)

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Clinical Characteristics of Gastrointestinal Diseases Associated with Iron Deficiency Anemia: Joong Ho Bae, Dong Soo Han, Jong Pyo Kim, Chang Hee Baek, Yong Woo Chung, Yong Cheol Jeon, Joo Hyun Sohn; Intest Res 2005;3(1):68-73. Published online June 30, 2005

Abstract PDF: Background/Aim: Gastrointestinal blood loss is the most common cause of Iron Deficiency Anemia (IDA) in men and postmenopausal women. Thus, esophagogastroduodenoscopy and colonoscopy are widely used to examine the gastrointestinal tract, in search for the cause of IDA. The purpose of this study was to identify clinical and biochemical variables that predicted the outcome of endoscopic findings in patients with IDA. Methods: Patients diagnosed as IDA from 2001 to 2004 were referred and retrogradely analyzed using their clinical, biological, endoscopic, and histological data. Results: 78 patients (21 men, 67 women: mean age 49.3 years) with IDA were enrolled, and 28.9% of patients had bleeding-related lesions. The mean age of patients with evidence of bleeding was 54.8 years, which was significantly higher compared with 43.7 years of the non-bleeding group (p=0.026). The reticulocyte count for the bleeding-related group was 2.8%, which was also significantly higher compared with 2.0% of the non-bleeding group (p=0.002). Conclusions: The prevalence of upper GI lesions were higher than lower GI lesions. Endoscopy revealed a source of IDA in 28.9% of cases. For hospitalized patients with IDA, endoscopy should be recommended to those older than 60 years of age, and those with increased reticulocyte count. (Intest Res 2005;3:68-73)

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