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Genetic Analysis in a Case of Turcot's Syndrome Associated with Cerebral Oligodendroglioma
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Han Soo Kim, Ji Young Park, Hyo Jong Kim, Sung-Gil Chi, Yoon Hwa Kim, Kil Yeon Lee, Yong Hee Joung, Yo Seb Han, Seok Ho Dong, Byung Ho Kim, Young Woon Chang, Joung Il Lee, Rin Chang
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Intest Res 2003;1(2):192-196. Published online November 27, 2003
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 Abstract
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- Turcot's syndrome (TS) is a genetic disease characterized by primary brain tumor, colon cancer and/or multiple colorectal polyps. The mode of genetic transmission of the syndrome still remains unclear because TS is a rare disorder. The majority of central nervous system (CNS) neoplasms associated with TS are glioma, glioblstoma multiformes and medulloblastoma. Other types of CNS tumors related to TS have been noted in a few case reports, and there are only two reports of oligodendroglioma associated with TS. To the authors' knowledge, this is the first case of a patient with TS who had a cerebral oligodendroglioma and a colorectal adenocarcinoma in Korea. Therefore, the authors performed genetic analysis of this patient and her family to determine the genetic variants, including mutations in APC gene and mismatch repair gene, in Turcot's syndrome. (Intestinal Research 2003;2:192-196)
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Comparison of Postoperative Ouality of Life in Ulcerative Colitis According to the Operative Method: Ileostomy versus Ileoanal Pouch Anastomosis
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Yong Hee Joung , Hyo Jong Kim, Kil Yeon Lee, Byoung Wook Lee, Yo Seb Han, Seok Ho Dong, Byung Ho Kim, Young Woon Chang, Joung Il Lee, Rin Chang
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Intest Res 2003;1(1):39-44. Published online May 27, 2003
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Abstract
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- Background/Aims
Ileostomy (IL) and ileal-pouch anal anastomosis (IPAA) are treatment of choice in ulcerative colitis. We investigate the complications and quality of life after operation according to the operative methods. Methods: We analyzed patients experienced total proctocolectomy. We divided them in two groups according to the operation methods. We analyzed the characteristics and outcomes after IL or IPAA group for evaluation quality of life and evaluated the characteristics of patients preoperative and postoperative state retrospectively. Results: Fourteen patients were enrolled this study. IPAA was done at eight of them and IL was done at the six of them. There were no difference in sex, age, frequency of use of immunosuppressive agent, duration of medication of steroid and duration of ulcerative colitis according to the operation methods. Most common indication of operation was medical intractability. Similar incidence of postoperative complication in both operation methods. According to the questionnares for evaluating of quality of life, we compared both operation method. There was no difference. But in IPAA, antidiarrheal medication was more needed. Conclusions: In IL and IPAA, quality of life was improved. There was no difference in quality of life in IL and IPAA. (Intestinal Research 2003;1:39-44)
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