Intestinal Research

Youran Gao

2 Articles

Inflammatory bowel diseases

Presentation and outcomes among inflammatory bowel disease patients with concurrent pneumatosis intestinalis: a case series and systematic review: Youran Gao, Meka Uffenheimer, Michael Ashamallah, Gregory Grimaldi, Arun Swaminath, Keith Sultan; Intest Res 2020;18(3):289-296. Published online November 4, 2019; DOI: https://doi.org/10.5217/ir.2019.00073

Background/Aims
Inflammatory bowel disease (IBD) involves chronic inflammation of the colon with ulcerative colitis (UC), and the colon and/or small intestine with Crohn’s disease (CD). Pneumatosis intestinalis (PI), characterized by compromise of the intestinal wall with gas-filled cysts, has rarely been reported with IBD. The presentation, best management and outcomes of PI with IBD are poorly defined.
Methods
We conducted a search for PI in all abdominal computed tomography (CT) reports at 2 large tertiary care hospitals from January 1, 2010 to December 31, 2017, cross referenced to ICD codes for IBD. CT and chart review was performed to confirm PI and IBD respectively. A systematic review excluding case reports was performed for PI with IBD for comparison.
Results
Of 5,990 patients with a CT abdomen report mentioning PI, we identified 11 cases of PI with IBD, 4 UC, 6 CD, and 1 indeterminate colitis. PI was limited to the small bowel in 5 patients, the right colon in 5, and small bowel and colonic in 1. All 3 mortalities had CD, small intestinal PI and portal/mesenteric venous gas. The systematic literature search identified 9 articles describing 58 patients with IBD and PI. These cases were mostly included in larger cohorts of PI patients without extractable data on presentation or outcomes in the IBD subpopulation.
Conclusions
Ours appears to be the first reporting of presentations and outcomes, outside of case reports, for those with PI and IBD. The high mortality for those with CD and PI of the small bowel appears to define a group requiring more than supportive medical care.

Citations

Citations to this article as recorded by

MR Enterography in Ulcerative Colitis: Beyond Endoscopy
Amir Reza Radmard, Mehrnam Amouei, Ala Torabi, Ali Reza Sima, Hiva Saffar, Amine Geahchan, Amir H. Davarpanah, Bachir Taouli
RadioGraphics.2024;[Epub] CrossRef
Plaque-like Mucosal Change in Pneumatosis Intestinalis with Ulcerative Colitis
Atsushi Ikehata, Machi Kiyohara, Sadahide Ono, Takashi Kajiwara
Internal Medicine.2024; 63(17): 2467. CrossRef
The Challenge of Pneumatosis Intestinalis: A Contemporary Systematic Review
Gennaro Perrone, Mario Giuffrida, Valentina Donato, Gabriele Luciano Petracca, Giorgio Rossi, Giacomo Franzini, Sara Cecconi, Alfredo Annicchiarico, Elena Bonati, Fausto Catena
Journal of Personalized Medicine.2024; 14(2): 167. CrossRef
Pneumatosis Intestinalis Manifesting as an Atypical Presentation of Crohn’s Disease
Charles Vallejo, Yousra Gheit, Talwinder K Nagi, Zoilo K Suarez, Muhammad Haider, Touqir Zahra
Cureus.2024;[Epub] CrossRef
The spectrum of pneumatosis intestinalis in the adult. A surgical dilemma
Giuseppe Tropeano, Marta Di Grezia, Caterina Puccioni, Valentina Bianchi, Gilda Pepe, Valeria Fico, Gaia Altieri, Giuseppe Brisinda
World Journal of Gastrointestinal Surgery.2023; 15(4): 553. CrossRef
Neumoperitoneo secundario a neumatosis intestinal masiva: un reporte de caso
David Charry-Borrero, Yesica Ascanio-Quintero, Juan Rodríguez-Valenzuela, Faure Yezid Rodríguez-Velásquez, Juan Felipe Coronado-Sarmiento, Eduardo Tuta-Quintero
Revista Colombiana de Cirugía.2023;[Epub] CrossRef
Idiopathic asymptomatic pneumoperitoneum in a patient with ureteric calculus and Crohn’s disease
Gitte Grunnet Raabe, Benedicte Schelde-Olesen, Thomas Bjørsum-Meyer
Journal of Surgical Case Reports.2022;[Epub] CrossRef
Pneumatosis Intestinalis Induced by Anticancer Treatment: A Systematic Review
Gianluca Gazzaniga, Federica Villa, Federica Tosi, Elio Gregory Pizzutilo, Stefano Colla, Stefano D’Onghia, Giusy Di Sanza, Giulia Fornasier, Michele Gringeri, Maria Victoria Lucatelli, Giulia Mosini, Arianna Pani, Salvatore Siena, Francesco Scaglione, An
Cancers.2022; 14(7): 1666. CrossRef
Pneumatosis Intestinalis Induced by Alpha-Glucosidase Inhibitors in Patients with Diabetes Mellitus
Blake J. McKinley, Mariangela Santiago, Christi Pak, Nataly Nguyen, Qing Zhong
Journal of Clinical Medicine.2022; 11(19): 5918. CrossRef

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Analysis of the clinical indications for opiate use in inflammatory bowel disease: Youran Gao, Sundas Khan, Meredith Akerman, Keith Sultan; Intest Res 2017;15(1):83-89. Published online January 31, 2017; DOI: https://doi.org/10.5217/ir.2017.15.1.83

Abstract PDF Supplementary Material PubReader ePub

<b>Background/Aims</b><br/>

Opiate use for inflammatory bowel disease (IBD), particularly high-dose (HD) use, is associated with increased mortality. It's assumed that opiate use is directly related to IBD-related complaints, although this hasn't been well defined. Our goal was to determine the indications for opiate use as a first step in developing strategies to prevent or decrease opiate use.

Methods

A retrospective cohort was formed of adults who were diagnosed with IBD and for whom outpatient evaluations from 2009 to 2014 were documented. Opiate use was defined if opiates were prescribed for a minimum of 30 days over a 365-day period. Individual chart notes were then reviewed to determine the clinical indication(s) for low-dose (LD) and HD opiate use.

Results

After a search of the electronic records of 1,109,277 patients, 3,226 patients with IBD were found. One hundred four patients were identified as opiate users, including 65 patients with Crohn's and 39 with ulcerative colitis; a total of 134 indications were available for these patients. IBD-related complaints accounted for 49.25% of the opiate indications, with abdominal pain (23.13%) being the most common. Overall, opiate use for IBD-related complaints (81.40% vs. 50.82%; P=0.0014) and abdominal pain (44.19% vs. 19.67%; P=0.0071) was more common among HD than among LD.

Conclusions

Our findings show that most IBD patients using opiates, particularly HD users, used opiates for IBD-related complaints. Future research will need to determine the degree to which these complaints are related to disease activity and to formulate non-opiate pain management strategies for patients with both active and inactive IBD.

Citations

Citations to this article as recorded by

Opioid Legislation in Patients With Inflammatory Bowel Disease: A State-wide Retrospective Cohort Study
Waseem Ahmed, Wade Billing, Timothy E Stump, Thomas Strobel, Sashidhar Sagi, Monika Fischer, Mathew Bohm
Inflammatory Bowel Diseases.2023; 29(9): 1355. CrossRef
Opioid use and associated factors in 1676 patients with inflammatory bowel disease: a multicentre quality improvement project
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Frontline Gastroenterology.2023; 14(6): 497. CrossRef
Abdominal pain in quiescent inflammatory bowel disease
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International Journal of Colorectal Disease.2021; 36(1): 93. CrossRef
High-Dose Opioid Use Among Veterans with Unexplained Gastrointestinal Symptoms Versus Structural Gastrointestinal Diagnoses
Salva N. Balbale, Lishan Cao, Itishree Trivedi, Jonah J. Stulberg, Katie J. Suda, Walid F. Gellad, Charlesnika T. Evans, Bruce L. Lambert, Neil Jordan, Laurie A. Keefer
Digestive Diseases and Sciences.2021; 66(11): 3938. CrossRef
Opioid Use Among Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis
Blake Niccum, Oluwatoba Moninuola, Kaia Miller, Hamed Khalili
Clinical Gastroenterology and Hepatology.2021; 19(5): 895. CrossRef
Pain in Inflammatory Bowel Disease Is Not Improved During Hospitalization: The Impact of Opioids on Pain and Healthcare Utilization
Sameer K. Berry, Will Takakura, Catherine Bresee, Gil Y. Melmed
Digestive Diseases and Sciences.2020; 65(6): 1777. CrossRef
Predictors of mortality in inflammatory bowel disease patients treated for pneumonia
Offir Ukashi, Yifatch Barash, Michael J. Segel, Bella Ungar, Shelly Soffer, Shomron Ben-Horin, Eyal Klang, Uri Kopylov
Therapeutic Advances in Gastroenterology.2020;[Epub] CrossRef
Integrated Psychological Care is Needed, Welcomed and Effective in Ambulatory Inflammatory Bowel Disease Management: Evaluation of a New Initiative
Taryn Lores, Charlotte Goess, Antonina Mikocka-Walus, Kathryn L Collins, Anne L J Burke, Anna Chur-Hansen, Paul Delfabbro, Jane M Andrews
Journal of Crohn's and Colitis.2019; 13(7): 819. CrossRef

5,743 View
48 Download
8 Web of Science
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