Intestinal Research

IBD

Combined eosinophilic gastroenteritis and ulcerative colitis successfully treated by vedolizumab: a case report: Hironobu Takedomi, Kayoko Fukuda, Suma Inoue, Nanae Tsuruoka, Yasuhisa Sakata, Shigehisa Aoki, Motohiro Esaki; Intest Res 2025;23(1):107-111. Published online August 29, 2024; DOI: https://doi.org/10.5217/ir.2024.00013

Abstract PDF PubReader ePub: A 47-year-old man with over 10 years’ duration of ulcerative colitis treated by 5-aminosalicylic acid and intermittent topical steroids complained of acute epigastric pain. Esophagogastroduodenoscopy revealed diffuse mucosal edema with patchy redness, multiple erosions and nodularity of the stomach. Bioptic examination revealed marked eosinophilic infiltration, confirming the diagnosis of eosinophilic gastroenteritis. Systemic steroid therapy was initiated, whereas his ulcerative colitis and eosinophilia recurred when tapering the steroid. Addition of azathioprine was ineffective, and we subsequently started vedolizumab for eosinophilic gastroenteritis and ulcerative colitis. The medication effectively improved his abdominal symptoms and esophagogastroduodenoscopy and ileocolonoscopy 1 year later revealed endoscopic improvement of both diseases with histologically decreased level of eosinophilic infiltration. Considering that eosinophils also express α4β7 integrins, vedolizumab can be a possible therapeutic candidate for eosinophilic gastroenteritis as well as ulcerative colitis.

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Miscellaneous

Endoscopic balloon dilations for strictures of rectum, ileocecal valve and duodenum in a patient with X-linked inhibitor of apoptosis deficiency: a case report: Shinsuke Otagiri, Takehiko Katsurada, Kensuke Sakurai, Junichi Sugita, Naoya Sakamoto; Intest Res 2022;20(2):274-277. Published online February 8, 2022; DOI: https://doi.org/10.5217/ir.2021.00029

Abstract PDF PubReader ePub: X-linked inhibitor of apoptosis (XIAP) deficiency is a rare primary immunodeficiency and gastrointestinal (GI) lesions in XIAP deficiency are similar to Crohn’s disease. For patients with Crohn’s disease, endoscopic balloon dilation (EBD) is known to be a standard procedure for intestinal strictures including upper GI tract. However, there are no articles which mention the efficacy of EBDs for the strictures in upper GI tract in patients with XIAP deficiency. Herein, we describe an 18-year-old male with XIAP deficiency in whom EBDs for the rectum, ileocecal valve (ICV), and duodenum were performed. Before hematopoietic stem cell transplantation (HSCT), GI endoscopy revealed strictures of the rectum, ICV and duodenum with active ulcers. Although these ulcers healed after HSCT, the strictures progressed. Therefore, we performed EBDs for the strictures of the rectum, ICV, and duodenum. In contrast studies, we did not find any other strictures in the small intestine. Throughout the patient’s clinical course, no complications of EBD occurred. He started eating after EBDs, but abdominal symptoms did not relapse without any dietary restrictions. Our case suggests that EBD could be an effective and safe procedure for intestinal strictures including upper GI tract after HSCT in patients with XIAP deficiency.

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IBD

Granulocyte and monocyte apheresis therapy for patients with active ulcerative colitis associated with COVID-19: a case report: Miki Koroku, Teppei Omori, Harutaka Kambayashi, Shun Murasugi, Tomoko Kuriyama, Yuichi Ikarashi, Maria Yonezawa, Ken Arimura, Kazunori Karasawa, Norio Hanafusa, Masatoshi Kawana, Katsutoshi Tokushige; Intest Res 2022;20(1):150-155. Published online March 12, 2021; DOI: https://doi.org/10.5217/ir.2020.00148

Abstract PDF PubReader ePub

Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is now a pandemic. Although several treatment guidelines have been proposed for patients who have both inflammatory bowel disease and COVID-19, immunosuppressive therapy is essentially not recommended, and the treatment options are limited. Even in the COVID-19 pandemic, adjuvant adsorptive granulocyte and monocyte apheresis may safely bring ulcerative colitis (UC) into remission by removing activated myeloid cells without the use of immunosuppressive therapy. Our patient was a 25-year-old Japanese male with UC and COVID-19. This is the first case report of the induction of UC remission with granulocyte and monocyte apheresis treatment for active UC associated with COVID-19.

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Phenotypic changes in immune cells induced by granulocyte and monocyte adsorptive apheresis in patients with severe COVID‐19: An ex vivo study
Ryo Hisamune, Kazuma Yamakawa, Katsuhide Kayano, Noritaka Ushio, Takeshi Wada, Kohei Taniguchi, Akira Takasu
Acute Medicine & Surgery.2024;[Epub] CrossRef
SARS-CoV-2 vaccination for adult patients with inflammatory bowel disease: expert consensus statement by KASID
Yoo Jin Lee, Seong-Eun Kim, Yong Eun Park, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seung-Jae Myung
Intestinal Research.2022; 20(2): 171. CrossRef
SARS-CoV-2 Vaccination for Adult Patients with Inflammatory Bowel Disease: Expert Consensus Statements by KASID
Yoo Jin Lee, Seong-Eun Kim, Yong Eun Park, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seung-Jae Myung
The Korean Journal of Gastroenterology.2021; 78(2): 117. CrossRef

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Miscellaneous

A case of autoimmune enteropathy with CTLA4 haploinsufficiency: Haruka Miyazaki, Namiko Hoshi, Michitaka Kohashi, Eri Tokunaga, Yuna Ku, Haruka Takenaka, Makoto Ooi, Nobuyuki Yamamoto, Suguru Uemura, Noriyuki Nishimura, Kazumoto Iijima, Keisuke Jimbo, Tsubasa Okano, Akihiro Hoshino, Kohsuke Imai, Hirokazu Kanegane, Ichiro Kobayashi, Yuzo Kodama; Intest Res 2022;20(1):144-149. Published online January 22, 2021; DOI: https://doi.org/10.5217/ir.2020.00041

Abstract PDF PubReader ePub

Autoimmune enteropathy (AIE) is a rare disease, characterized by intractable diarrhea, villous atrophy of the small intestine, and the presence of circulating anti-enterocyte autoantibodies. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome, and mutations in FOXP3, which is a master gene of regulatory T cells (Tregs), are major causes of AIE. Recent studies have demonstrated that mutations in other Treg-associated genes, such as CD25 and CTLA4, show an IPEX-like phenotype. We present the case of a 13-year-old girl with CTLA4 haploinsufficiency, suffering from recurrent immune thrombocytopenic purpura and intractable diarrhea. We detected an autoantibody to the AIE-related 75 kDa antigen (AIE-75), a hallmark of the IPEX syndrome, in her serum. She responded well to a medium dose of prednisolone and a controlled dose of 6-mercaptopurine (6-MP), even after the cessation of prednisolone administration. Serum levels of the soluble interleukin-2 receptor and immunoglobulin G (IgG) were useful in monitoring disease activity during 6-MP therapy. In conclusion, autoimmune-mediated mechanisms, similar to the IPEX syndrome, may be involved in the development of enteropathy in CTLA4 haploinsufficiency. Treatment with 6-MP and monitoring of disease activity using serum levels of soluble interleukin-2 receptor and IgG is suggested for such cases.

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Advances and challenges in diagnosing and managing adult autoimmune enteropathy
Grigorios Christodoulidis, Sara E Agko, Marina N Kouliou, Konstantinos E Koumarelas, Dimitris Zacharoulis
World Journal of Gastroenterology.2025;[Epub] CrossRef
Engineering nanoparticle therapeutics for food allergy
Laila M. Rad, Gabriel Arellano, Joseph R. Podojil, Jessica J. O’Konek, Lonnie D. Shea, Stephen D. Miller
Journal of Allergy and Clinical Immunology.2024; 153(3): 549. CrossRef
Understanding the Spectrum of Immune Dysregulation Manifestations in Autoimmune Lymphoproliferative Syndrome and Autoimmune Lymphoproliferative Syndrome-like Disorders
Christopher Failing, Jennifer R. Blase, Kelly Walkovich
Rheumatic Disease Clinics of North America.2023; 49(4): 841. CrossRef
Severe Immune-Related Enteritis after In Utero Exposure to Pembrolizumab
Manuel A. Baarslag, Joosje H. Heimovaara, Jessica S.W. Borgers, Koen J. van Aerde, Hans J.P.M. Koenen, Ruben L. Smeets, Pauline L.M. Buitelaar, Dick Pluim, Shoko Vos, Stefanie S.V. Henriet, Jan Willem B. de Groot, Martine van Grotel, Hilde Rosing, Jos H.
New England Journal of Medicine.2023; 389(19): 1790. CrossRef
Clinical Courses of IKAROS and CTLA4 Deficiencies: A Systematic Literature Review and Retrospective Longitudinal Study
Akihiro Hoshino, Etsushi Toyofuku, Noriko Mitsuiki, Motoi Yamashita, Keisuke Okamoto, Michio Yamamoto, Kenji Kanda, Genki Yamato, Dai Keino, Yuri Yoshimoto-Suzuki, Junji Kamizono, Yasuhiro Onoe, Takuya Ichimura, Mika Nagao, Masaru Yoshimura, Koji Tsugawa,
Frontiers in Immunology.2022;[Epub] CrossRef
Treg specialization and functions beyond immune suppression
Jillian L Astarita, Claudia X Dominguez, Corey Tan, Jovanny Guillen, Mariela L Pauli, Rosario Labastida, Jose Valle, Melanie Kleinschek, Jesse Lyons, Ali A Zarrin
Clinical and Experimental Immunology.2022;[Epub] CrossRef

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IBD

Pediatric Crohn’s disease with severe morbidity manifested by gastric outlet obstruction: two cases report and review of the literature: Eun Sil Kim, Ji Hyung Park, Yon Ho Choe, Mi Jin Kim; Intest Res 2021;19(4):472-477. Published online October 29, 2020; DOI: https://doi.org/10.5217/ir.2020.00072

Abstract PDF PubReader ePub

Crohn’s disease (CD) presenting as gastric outlet obstruction is rare but serious clinical presentation of CD causing severe morbidity. However, there have been few case reports concerning this disorder in East Asian children and adolescents. The current case report describes 2 pediatric patients with CD who had had gastric outlet obstruction as an initial symptom of CD. Two pediatric patients developed postprandial vomiting, bloating, and unintentional weight loss. The upper endoscopy result indicated that there was pyloric obstruction with mucosal edema, inflammation and ulcers. The serologic test and colonoscopy results suggested CD. These patients were treated with infliximab, and endoscopic balloon dilation without surgery and showed remarkable improvement in obstructing symptoms with maintaining clinical and biochemical remission. This case report elucidates the benefits of early intervention using infliximab and endoscopic balloon dilation to improve gastric outlet obstruction and achieve baseline recovery in patients with upper gastrointestinal B2 phenotype of CD.

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Upper gastrointestinal tract involvement of Crohn disease: clinical implications in children and adolescents
Eun Sil Kim, Mi Jin Kim
Clinical and Experimental Pediatrics.2022; 65(1): 21. CrossRef

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Miscellaneous

Hydroxyurea associated ileocecal valve ulcer: evidence for causality: Thevaraajan Jayaraman, Ruveena Bhavani Rajaram, Gin Gin Gan, Ida Hilmi; Intest Res 2021;19(4):468-471. Published online December 1, 2020; DOI: https://doi.org/10.5217/ir.2020.00099

Abstract PDF PubReader ePub

Hydroxyurea is an antimetabolite drug that is commonly used in many hematological disorders. Ulcer formation in the gastrointestinal tract is a rare phenomenon associated with this drug. We report a case of a 73-year-old woman who was found to have an isolated ileocecal valve ulcer while on hydroxyurea 1 g daily for essential thrombocythemia. A comprehensive evaluation ruled out all other causes. The cytoreductive therapy was switched to anagrelide and the endoscopic evaluation 6 months later showed complete healing of the ulcer. However, the hydroxyurea was resumed due to increasing platelet counts and intolerance to dose increments of the anagrelide. Subsequently, the patient was found to have a recurrence of the ulcer. Apart from oral ulcers, there have also been reports of ulcers involving the small bowel and the colon associated with the use of hydroxyurea. The pathophysiology of the non-oral gastrointestinal ulceration in relation to this drug is unclear. Withdrawal of the drug typically leads to complete resolution. Increasing awareness of the rare association between the use of hydroxyurea and nonoral gastrointestinal ulcers is essential for early detection to prevent related complications.

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Esophageal and Ileal Ulcers Caused by Hydroxycarbamide: A Case Report and Literature Review
Takumi Inaba, Yu Yamamoto, Kaho Hirayama, Takuma Kobayashi, Naoto Izumi, Hirotsugu Sakamoto, Shuji Hatakeyama, Masami Matsumura
Internal Medicine.2025; 64(6): 845. CrossRef
Hydroxyurea-related ileocecal region ulcers as a rare complication: A case report
Wen-Jin Yuan, Yi-Juan Zheng, Bing-Rong Zhang, Yi-Jie Lin, You Li, Yan-Yan Qiu, Xue-Ping Yu
World Journal of Clinical Cases.2025;[Epub] CrossRef
Repairing of recurrent leg ulcer induced by hydroxyurea with posterior tibial artery perforator propeller flap: Case report
Zheng-Dong Wan, Wu-Zhou Li
International Journal of Surgery Case Reports.2024; 114: 109049. CrossRef

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IBD

Non-cirrhotic portal hypertension related to azathioprine therapy in a patient with Crohn’s disease: Jong Won Seo, Eun Soo Kim, Man-Hoon Han, Young Oh Kweon; Intest Res 2021;19(2):247-251. Published online July 2, 2020; DOI: https://doi.org/10.5217/ir.2020.00016

Abstract PDF PubReader ePub

Azathioprine is widely used for the treatment of Crohn’s disease (CD). Few cases from Western countries have reported idiopathic non-cirrhotic portal hypertension (NCPH) related to thiopurine therapy in patients with inflammatory bowel disease. Idiopathic NCPH is a rare hepatic condition with intrahepatic portal hypertension but no evidence of cirrhosis or chronic liver disease. Patients with idiopathic NCPH present with symptoms of portal hypertension such as thrombocytopenia, splenomegaly and esophageal varices. We report a case of idiopathic NCPH in a 51-year-old male patient with CD who had been taking azathioprine for 5 years. He was admitted due to esophageal variceal bleeding along with splenomegaly and thrombocytopenia. Evaluation of cirrhosis or chronic liver disease showed normal-range results as estimated by FibroScan evaluation, laboratory examination for autoimmune hepatitis or viral hepatitis, and liver biopsy. This case may suggest the need for careful monitoring for manifestations of portal hypertension in Asian patients with inflammatory bowel disease receiving thiopurine treatment.

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Non-cirrhotic Idiopathic portal hypertension in systemic sclerosis patients: report of one case and a systematic review of previous case reports
Felipe Souza da Silva, João Victor de Pinho Costa, Carlos Alberto dos Santos Júnior, Érika Emmylaine dos Santos, Ailton José de Castro Júnior, Ana Cecília de Sena Oliveira, Flávia Patrícia Sena Teixeira Santos, Adriana Maria Kakehasi, Débora Cerqueira Cal
Advances in Rheumatology.2025;[Epub] CrossRef
Exploring the link: Porto-sinusoidal vascular disorder and inflammatory bowel disease – A comprehensive narrative review
Nicola Pugliese, Lucia Giuli, Elisabetta Mastrorocco, Francesco Santopaolo, Giacomo Marcozzi, Cristina Bezzio, Arianna Dal Buono, Roberto Gabbiadini, Antonio Gasbarrini, Francesca Romana Ponziani, Alessandro Armuzzi, Alessio Aghemo
Digestive and Liver Disease.2024; 56(6): 964. CrossRef
Non-Cirrhotic Portal Hypertension: an Overview
Sajid Jalil, Ashwani K. Singal
Current Hepatology Reports.2024; 23(1): 153. CrossRef
Hepatic Steatosis but Not Fibrosis Is Independently Associated with Poor Outcomes in Patients with Inflammatory Bowel Disease
Hye Kyung Hyun, Hye Won Lee, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Seung Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Seung Up Kim, Jae Hee Cheon
Gut and Liver.2024; 18(2): 294. CrossRef
A Narrative Review on Non-Cirrohotic Portal Hypertension: Not All Portal Hypertensions Mean Cirrhosis
Michele Fiordaliso, Giuseppe Marincola, Barbara Pala, Raffaella Muraro, Mariangela Mazzone, Maria Carmela Di Marcantonio, Gabriella Mincione
Diagnostics.2023; 13(20): 3263. CrossRef
Nichtzirrhotische portale Hypertension – Ursachen und praktisches Management
A. Queck, J. Trebicka
Der Gastroenterologe.2021; 16(2): 90. CrossRef

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Infection

Whipple disease mimicking inflammatory bowel disease: Maiko Tatsuki, Takashi Ishige, Yoshiko Igarashi, Reiko Hatori, Akira Hokama, Junko Hirato, Aleixo Muise, Takumi Takizawa, Hirokazu Arakawa; Intest Res 2021;19(1):119-125. Published online July 3, 2020; DOI: https://doi.org/10.5217/ir.2019.09177

Abstract PDF PubReader ePub

Whipple disease is a systemic chronic infection caused by Tropheryma whipplei. Although chronic diarrhea is a common gastrointestinal symptom, diagnosis is often difficult because there are no specific endoscopic findings, and the pathogen is not detectable by stool culture. We present a female patient with Whipple disease who developed chronic bloody diarrhea and growth retardation at the age of 4 years. Colonoscopy showed a mildly edematous terminal ileum and marked erythema without vascular patterns throughout the sigmoid colon and rectum. Subsequently, a primary diagnosis of ulcerative colitis was made. Histopathological analysis of the terminal ileum showed the presence of foamy macrophages filled with periodic acidSchiff-positive particles. Polymerase chain reaction using DNA from a terminal ileum biopsy sample amplified a fragment of 16S rRNA from T. whipplei. Antibiotic treatment relieved the patient’s symptoms. There was no evidence of immunodeficiency in the present case. Since Whipple disease worsens after anti-tumor necrosis factor inhibitor therapy, considering this infection in the differential diagnosis may be important in patients with inflammatory bowel disease, especially before initiation of immunotherapy.

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Through the Looking Glass: A Child With Arthralgia, Malaise and Weight Loss
Aline R. Verhage, Iris D. Nagtegaal, Cathelijne van der Feen, Tom F.W. Wolfs
Pediatric Infectious Disease Journal.2023; 42(7): 629. CrossRef
Enfermedad de Whipple: revisión sistemática de la literatura
Ledmar Jovanny Vargas Rodriguez, Jeinny Lucero Ruiz Muñoz, Paola Andrea Bolivar Córdoba, Monica Dayana Romero Cely, Ervirson Jair Cañon Abril, Zulma Marisol Suarez Correa, María Angélica Mendoza Cáceres
Revista colombiana de Gastroenterología.2023; 38(1): 35. CrossRef
Whipple’s Disease with Colonic Involvement: A Rare Endoscopic Documentation
Verónica Gamelas, Ines Canha, João Pimentel, Sara Santos, Verónica Borges, Carlos Bernardes
GE - Portuguese Journal of Gastroenterology.2022; 29(6): 436. CrossRef
Whipple’s disease with normal duodenal histology diagnosed by ileal biopsy using balloon endoscopy
Hideki Mori, Chiaki Yakabi, Kiwamu Yonahara, Kazunao Hamahiga, Miyu Yoshimura, Masaki Sakihara, Kenji Ishihara, Kinya Azama, Takayuki Chinen, Osamu Zaha
Clinical Journal of Gastroenterology.2022; 15(4): 702. CrossRef

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Inflammatory bowel diseases

Long-term outcome after surgery in a patient with intestinal Behçet’s disease complicated by myelodysplastic syndrome and trisomy 8: Yuki Mori, Fumihiko Iwamoto, Yasuaki Ishida, Toru Kuno, Shoji Kobayashi, Takashi Yoshida, Tatsuya Yamaguchi, Tadashi Sato, Makoto Sudo, Daisuke Ichikawa, Nobuyuki Enomoto; Intest Res 2020;18(4):469-475. Published online May 12, 2020; DOI: https://doi.org/10.5217/ir.2019.09141

Abstract PDF PubReader ePub

Behçet’s disease (BD) is a multisystem inflammatory disease of unknown origin. Rarely, BD occurs together with myelodysplastic syndrome (MDS). Interestingly, it is speculated that these are not simple coexistence but that the etiology of intestinal BD is at least partly derived from MDS itself. Furthermore, there is a relationship between MDS in patients with intestinal BD and trisomy 8. Immunosuppressive agents alone are insufficient to control MDS-associated BD, and many of these patients die of infection or hemorrhage. Surgery is considered for intestinal BD patients who are unresponsive to medical treatment or those with bowel complications such as perforation or persistent bleeding. We report a case of intestinal BD associated with MDS and trisomy 8. The patient was unresponsive to oral steroids and immunosuppressive treatment; the patient improved by surgical repair of a bowel perforation. Five years after the surgery, the patient is free of recurrence and not on medication. Our experience suggests that surgery may provide an effective therapeutic option for the treatment of MDS-related BD.

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Optimal Treatment Approaches to Intestinal Behçet's Disease Complicated by Myelodysplastic Syndrome: The KASID and KSBD Multicenter Study
Jung-Bin Park, So Jung Han, Seung Bum Lee, Dong Hyun Kim, Jae Hee Cheon, Sung Wook Hwang, Byong Duk Ye, Suk-Kyun Yang, Soo Jung Park, Sang Hyoung Park
Yonsei Medical Journal.2024; 65(5): 265. CrossRef
Long‐term clinical outcomes of intestinal Behçet's disease: A 30‐year cohort study at a tertiary hospital in South Korea
Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Hee Cheon
Journal of Gastroenterology and Hepatology.2023; 38(3): 386. CrossRef
Interplay between chronic inflammation and clonal haematopoiesis of indeterminate potential in Behçet’s disease
Jihye Park, Hongyul An, Jiwoo Lim, I Seul Park, Mi Hyun Kim, Ji Hyung Kim, Seung Won Kim, Young Il Koh, Eun Young Lee, Jae Hee Cheon
Arthritis Research & Therapy.2023;[Epub] CrossRef
Real-world effectiveness and safety of adalimumab in Korean patients with intestinal Behcet’s disease: a Korean Association for the Study of Intestinal Diseases (KASID) multicenter study
Seung Bum Lee, Hee Seung Hong, Chang Kyun Lee, Bo-In Lee, Sol Kim, Seong-Joon Koh, Hosun Yu, Jung-Bin Park, Sung Wook Hwang, Byong Duk Ye, Suk-Kyun Yang, Sang Hyoung Park
The Korean Journal of Internal Medicine.2023; 38(5): 661. CrossRef
Effectiveness and safety of adalimumab in patients with intestinal Behçet’s disease: a real-world prospective observational study in South Korea
Jongwook Yu, Sung Jae Shin, Yune-Jung Park, Hyung Wook Kim, Bo-In Lee, Byong Duk Ye, Geun-Tae Kim, Sung Kook Kim, Joo Sung Kim, Young-Ho Kim, Seonjeong Jeong, Jae Hee Cheon
BMC Gastroenterology.2023;[Epub] CrossRef
Trisomy 8-positive Polycythemia Vera Complicated with Intestinal Behçet's-like Disease: A New Perspective for a Clinical Approach
Yuki Mori, Fumihiko Iwamoto, Toru Kuno, Shoji Kobayashi, Takashi Yoshida, Tatsuya Yamaguchi, Shinichi Takano, Tetsuo Kondo, Keita Kirito, Nobuyuki Enomoto
Internal Medicine.2022; 61(11): 1713. CrossRef
Clinical Course of Patients with Intestinal Behçet’s Disease According to Consensus-Based Diagnostic Categories
Yu Young Joo, Bo-In Lee, Seung-Jun Kim, Han Hee Lee, Jin Su Kim, Jae Myung Park, Young-Seok Cho, Kang Moon Lee, Sang Woo Kim, Hwang Choi, Myung-Gyu Choi
Gut and Liver.2022; 16(5): 746. CrossRef

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Inflammatory bowel diseases

Incidental benefits after fecal microbiota transplant for ulcerative colitis: Ramit Mahajan, Vandana Midha, Arshdeep Singh, Varun Mehta, Yogesh Gupta, Kirandeep Kaur, Ritu Sudhakar, Anmol Singh Pannu, Dharmatma Singh, Ajit Sood; Intest Res 2020;18(3):337-340. Published online April 22, 2020; DOI: https://doi.org/10.5217/ir.2019.00108

Abstract PDF PubReader ePub

Gut dysbiosis can result in several diseases, including infections (Clostridium difficile infection and infectious gastroenteritis), autoimmune diseases (inflammatory bowel disease, diabetes, and allergic disorders), behavioral disorders and other conditions like metabolic syndrome and functional gastrointestinal disorders. Amongst various therapies targeting gut microbiome, fecal microbiota transplantation (FMT) is becoming a focus in the public media and peer reviewed literature. We have been using FMT for induction of remission in patients with moderate to severe active ulcerative colitis (UC) and also for subsequent maintenance of remission. Four cases reported incidental benefits while being treated with FMT for UC. These included weight loss (n=1), improvement in hair loss (n=1), amelioration of axial arthritis (n=1) and improvement in allergic rhinitis (n=1), thereby suggesting potential clinical applications of FMT in treating extraintestinal diseases associated with gut dysbiosis.

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Fecal microbiota transplantation in allergic diseases
Ece Tüsüz Önata, Öner Özdemir
World Journal of Methodology.2025;[Epub] CrossRef
16S rRNA sequencing-based evaluation of the protective effects of key gut microbiota on inhaled allergen-induced allergic rhinitis
Yi Tang, Yongchuan She, Danping Chen, Yibo Zhou, Dan Xie, Zhai Liu
Frontiers in Microbiology.2025;[Epub] CrossRef
α‐Lipoic acid alleviates dextran sulfate sodium salt‐induced ulcerative colitis via modulating the Keap1–Nrf2 signaling pathway and inhibiting ferroptosis
Peng Jiang, Zongzhen Zhai, Linxian Zhao, Kai Zhang, Liwei Duan
Journal of the Science of Food and Agriculture.2024; 104(3): 1679. CrossRef
Effects of dietary imbalances of micro- and macronutrients on the ocular microbiome and its implications in dry eye disease
Madeline Pilkington, Declan Lloyd, Brad Guo, Stephanie L. Watson, Kenneth Gek-Jin Ooi
Exploration of Medicine.2024; : 127. CrossRef
Compositional changes in fecal microbiota associated with clinical phenotypes and prognosis in Korean patients with inflammatory bowel disease
Seung Yong Shin, Young Kim, Won-Seok Kim, Jung Min Moon, Kang-Moon Lee, Sung-Ae Jung, Hyesook Park, Eun Young Huh, Byung Chang Kim, Soo Chan Lee, Chang Hwan Choi
Intestinal Research.2023; 21(1): 148. CrossRef
Case report: Fecal microbiota transplantation in refractory ankylosing spondylitis
Lei Wang, Zhimin Wei, Fei Pan, Chuan Song, Lihua Peng, Yunsheng Yang, Feng Huang
Frontiers in Immunology.2023;[Epub] CrossRef
Gut-spine axis: a possible correlation between gut microbiota and spinal degenerative diseases
Tadatsugu Morimoto, Takaomi Kobayashi, Toshihiko Kakiuchi, Motohiro Esaki, Masatsugu Tsukamoto, Tomohito Yoshihara, Hirohito Hirata, Shoji Yabuki, Masaaki Mawatari
Frontiers in Microbiology.2023;[Epub] CrossRef
Gut microbiota changes in patients with spondyloarthritis: A systematic review
Lei Wang, Yiwen Wang, Pei Zhang, Chuan Song, Fei Pan, Gang Li, Lihua Peng, Yunsheng Yang, Zhimin Wei, Feng Huang
Seminars in Arthritis and Rheumatism.2022; 52: 151925. CrossRef
Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 diseases
Yun Wang, Sheng Zhang, Thomas J. Borody, Faming Zhang
Chinese Medical Journal.2022;[Epub] CrossRef
Clinical Application and Progress of Fecal Microbiota Transplantation in Liver Diseases: A Review
Xinpei Gu, Qin Lu, Chengcheng Zhang, Zhewei Tang, Liuxi Chu
Seminars in Liver Disease.2021; 41(04): 495. CrossRef
Intestinal microbiota and inflammatory bowel diseases
Chang Soo Eun
Journal of the Korean Medical Association.2021; 64(9): 588. CrossRef

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Inflammatory bowel diseases

Inflammatory bowel disease and superior mesenteric artery thromboembolism: Steven Nicolaides, Abhinav Vasudevan, Daniel Van Langenberg; Intest Res 2020;18(1):130-133. Published online September 3, 2019; DOI: https://doi.org/10.5217/ir.2019.00068

Abstract PDF PubReader ePub

While patients with inflammatory bowel disease are known to be at increased risk of venous thromboembolism, the risk of arterial thrombosis is less well recognized. Here, we describe the case of a middle-aged female with a recent diagnosis of Crohn’s disease who presented to her local emergency department with acute abdominal pain. Subsequent investigations revealed a thrombus in the superior mesenteric artery resulting in multi-organ infarction requiring major intra-abdominal surgery and extensive resection of segments of small and large bowel.

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Etiology and Risk Factors for Splanchnic Vein Thrombosis in Non-Cirrhotic, Non-Neoplastic Patients: A Narrative Review
Mihaela Hostiuc, Ionut Negoi
Medicina.2025; 61(5): 933. CrossRef
Navigating the Gut-Cardiac Axis: Understanding Cardiovascular Complications in Inflammatory Bowel Disease
Tanya Sinha, Zukhruf Zain, Syed Faqeer Hussain Bokhari, Sarosh Waheed, Taufiqa Reza, Anthony Eze-Odurukwe, Mitwa Patel, Mohammed Khaleel I KH Almadhoun , Azlaan Hussain, Ibrahim Reyaz
Cureus.2024;[Epub] CrossRef
Microscopic Colitis: An Underestimated Disease of Growing Importance
Kamil Rutkowski, Karina Udrycka, Barbara Włodarczyk, Ewa Małecka-Wojciesko
Journal of Clinical Medicine.2024; 13(19): 5683. CrossRef
Venous Thromboembolism Risk in Asian Patients with Inflammatory Bowel Disease: A Population-Based Nationwide Inception Cohort Study
Su Young Kim, Yeon Seo Cho, Hyun-Soo Kim, Jung Kuk Lee, Hee Man Kim, Hong Jun Park, Hyunil Kim, Jihoon Kim, Dae Ryong Kang
Gut and Liver.2022; 16(4): 555. CrossRef
Thromboembolic Events in Patients with Inflammatory Bowel Disease: A Comprehensive Overview
Dhir Gala, Taylor Newsome, Nicole Roberson, Soo Min Lee, Marvel Thekkanal, Mili Shah, Vikash Kumar, Praneeth Bandaru, Vijay Gayam
Diseases.2022; 10(4): 73. CrossRef

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Colorectal neoplasia

Primary malignant melanoma without melanosis of the colon: Nam Hee Yi, Sang Heon Lee, Sang Heon Lee, Ji Hyun Kim, Sam Ryong Jee, Sang Yong Seol; Intest Res 2019;17(4):561-564. Published online August 5, 2019; DOI: https://doi.org/10.5217/ir.2019.00020

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Primary malignant melanoma (PMM) of the gastrointestinal tract is rare. Reported cases of PMM of the lower gastrointestinal tract typically describe anal and rectal involvement rather than colonic lesions. This report describes a rare case of a 50-year-old woman with PMM originating in the colon. The patient presented to Inje University Busan Paik Hospital with a 3-day history of blood-tinged stools. She underwent colonoscopy for a diagnosis of hematochezia. The colonoscopic examination revealed a large-sized semi-pedunculated sigmoid colon polyp with a reddish-colored mucosal surface. Endoscopic mucosal resection was performed, and the final histopathological findings were consistent with a diagnosis of malignant melanoma. Systemic work-up was performed for assessment of metastasis and to identify the primary tumor considering the high metastatic rate of gastrointestinal malignant melanoma; however, no other malignant lesion was detected. Thus, she was diagnosed with colonic PMM. She underwent laparoscopic low anterior resection and lymph node dissection and has been recurrence-free for > 2 years.

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Malignant primary melanoma of the colon: a case report
Claire K Foley, Marybeth S Hughes, Charles T Hehman
Journal of Surgical Case Reports.2023;[Epub] CrossRef

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IBD

Remission of diffuse ulcerative duodenitis in a patient with ulcerative colitis after infliximab therapy: a case study and review of the literature: Yong-Sung Choi, Jong Kyu Kim, Wan Jung Kim, Mi-Jung Kim; Intest Res 2019;17(2):273-277. Published online February 12, 2019; DOI: https://doi.org/10.5217/ir.2018.00122

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Although ulcerative colitis (UC) is confined to colonic and rectal mucosa in a continuous fashion, recent studies have also demonstrated the involvement of upper gastrointestinal tract as diagnostic endoscopy becomes more available and technically advanced. The pathogenesis of UC is not well established yet. It might be associated with an inappropriate response of host mucosal immune system to gut microflora. Although continuous and symmetric distribution of mucosal inflammation from rectum to colon is a typical pattern of UC, clinical feature and course of atypically distributed lesions in UC might also help us understand the pathogenesis of UC. Herein, we report a case of duodenal involvement of UC which successfully remitted after infliximab therapy. Endoscopic and pathologic findings before and after administration of anti-tumor necrosis factor suggest that the pathogenesis of upper gastrointestinal involvement of UC may be similar to that of colon involvement.

Citations

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A case of relapsed pan-colonic ulcerative colitis accompanied with gastroduodenal lesions immediately after COVID-19
Katsuya Endo, Tomonori Satoh, Yuki Yoshino, Shiho Kondo, Yoko Kawakami, Daisuke Fukushi, Atsuko Takasu, Takayuki Kogure, Morihisa Hirota, Kennichi Satoh
Clinical Journal of Gastroenterology.2025; 18(3): 399. CrossRef
Gastroduodenitis Associated with Active Ulcerative Colitis Treated with Infliximab: Different Clinical Course in the Colon and Gastroduodenal Lesions
Tomoyuki Hayashi, Takeshi Terashima, Masaki Nishitani, Noriaki Orita, Masaki Miyazawa, Akihiro Seki, Hidetoshi Nakagawa, Kouki Nio, Noriho Iida, Shinya Yamada, Hajime Takatori, Tetsuro Shimakami, Taro Yamashita
Internal Medicine.2024; 63(7): 929. CrossRef
Severe Disease Activity May Predispose Patients to Post-colectomy Duodenitis Associated with Ulcerative Colitis
Akira Sonoda, Naoki Yoshimura, Minako Sako, Soh Okano, Satoshi Saito, Masakazu Takazoe, Satomi Furukawa, Kinya Okamoto, Tetsuo Yamana, Hisateru Tachimori, Masayuki Fukata
Internal Medicine.2024; 63(10): 1337. CrossRef
Concurrent occurrence of ulcerative duodenitis and ulcerative colitis displaying unique responses to golimumab and ustekinumab
Sho Masaki, Hajime Honjo, Masayuki Kurimoto, Natsuki Okai, Yasuo Otsuka, Yasuhiro Masuta, Ken Kamata, Kosuke Minaga, Masatoshi Kudo, Tomohiro Watanabe
Clinical Journal of Gastroenterology.2024; 17(5): 854. CrossRef
Upper Gastrointestinal Tract Involvement in Inflammatory Bowel Diseases: Histologic Clues and Pitfalls
Bence Kővári, Rish K. Pai
Advances in Anatomic Pathology.2022; 29(1): 2. CrossRef
Mucosal lesions of the upper gastrointestinal tract in patients with ulcerative colitis: A review
Yan Sun, Zhe Zhang, Chang-Qing Zheng, Li-Xuan Sang
World Journal of Gastroenterology.2021; 27(22): 2963. CrossRef
Clinical characteristics and prognosis of patients with ulcerative colitis that shows rectal sparing at initial diagnosis
Yong-Sung Choi, Jong-Kyu Kim, Wan-Jung Kim
World Journal of Gastrointestinal Endoscopy.2021; 13(9): 407. CrossRef
Upper Gastrointestinal Manifestations of Inflammatory Bowel Disease
Noam Harpaz, Alexandros D. Polydorides
Surgical Pathology Clinics.2020; 13(3): 413. CrossRef
Two Cases of Ulcerative Colitis-like Gastroduodenitis after Total Proctocolectomy for Intractable Ulcerative Colitis
Takahiro SHIMOYAMA, Takayuki YAMAMOTO, Yasuhiro INOUE, Satoru UMEGAE
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2019; 80(5): 904. CrossRef

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IBD

Acute pancreatitis associated with indigo naturalis in pediatric severe Crohn’s disease: Hyeon-A Kim, Hyo-rim Suh, Ben Kang, Byung-Ho Choe, on behalf of Crohn’s and Colitis Association in DaeguGyeongbuk (CCAiD); Intest Res 2019;17(1):144-148. Published online October 16, 2018; DOI: https://doi.org/10.5217/ir.2018.00104

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The incidence of inflammatory bowel disease (IBD) is rapidly increasing worldwide. Indigo naturalis is known to have an antiinflammatory effect. Indigo naturalis has been traditionally used in the treatment of IBD in China and Japan. Currently, it is used as a primary or adjunctive drug in patients with ulcerative colitis. There are some reports of the effects of indigo naturalis when used in patients with ulcerative colitis. However, its usage has been associated with adverse events, including liver dysfunction, headache, gastrointestinal disturbance, and pulmonary hypertension. Pancreatitis as an adverse event during treatment using indigo naturalis has not yet been reported. We report a case of recurrent events of pancreatitis that occurred briefly after starting medication with indigo naturalis in a child with severe Crohn’s disease. The pancreatitis improved after indigo naturalis was discontinued in 2 events. This is the first case to report the association between pancreatitis and indigo naturalis in the English literature.

Citations

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Selected Use of Complementary and Alternative Medicine (CAM) Agents in IBD
Monica Dzwonkowski, Janak Bahirwani, Samantha Rollins, Alicia Muratore, Vikram Christian, Yecheskel Schneider
Current Gastroenterology Reports.2025;[Epub] CrossRef
One-year clinical efficacy and safety of indigo naturalis for active ulcerative colitis: a real-world prospective study
Yuichi Matsuno, Takehiro Torisu, Junji Umeno, Hiroki Shibata, Atsushi Hirano, Yuta Fuyuno, Yasuharu Okamoto, Shin Fujioka, Keisuke Kawasaki, Tomohiko Moriyama, Tomohiro Nagasue, Keizo Zeze, Yoichiro Hirakawa, Shinichiro Kawatoko, Yutaka Koga, Yoshinao Oda
Intestinal Research.2022; 20(2): 260. CrossRef
Pancreatic Disorders in Children with Inflammatory Bowel Disease
Piotr Jakimiec, Katarzyna Zdanowicz, Kamila Kwiatek-Sredzinska, Aleksandra Filimoniuk, Dariusz Lebensztejn, Urszula Daniluk
Medicina.2021; 57(5): 473. CrossRef
Accumulation mechanism of indigo and indirubin in Polygonum tinctorium revealed by metabolite and transcriptome analysis
Wenjing Wang, Yuan Wu, Huihui Xu, Yuan Shang, Yichen Chen, Miaoer Yan, Zhaohui Li, David R. Walt
Industrial Crops and Products.2019; 141: 111783. CrossRef

7,806 View
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IBD

5-Aminosalicylic acid aggravates colitis mimicking exacerbation of ulcerative colitis: Jun Miyoshi, Katsuyoshi Matsuoka, Atsushi Yoshida, Makoto Naganuma, Tadakazu Hisamatsu, Tomoharu Yajima, Nagamu Inoue, Susumu Okamoto, Yasushi Iwao, Haruhiko Ogata, Fumiaki Ueno, Toshifumi Hibi, Takanori Kanai; Intest Res 2018;16(4):635-640. Published online October 10, 2018; DOI: https://doi.org/10.5217/ir.2018.00015

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Ulcerative colitis (UC) is one of the major clinical phenotypes of inflammatory bowel diseases. Although 5-aminosalicylic acid (5-ASA) is widely used for UC and its efficacy and safety have been demonstrated, a few patients paradoxically develop a severe exacerbation of colitis by 5-ASA administration. It is crucial to know clinical features including endoscopic findings in this condition for making a correct diagnosis and a prompt decision to withdraw the medication. Here, we report case series with UC exacerbated by 5-ASA. Medical records of 8 UC patients experiencing an exacerbation of colitis after induction of 5-ASA that was improved by the withdrawal of 5-ASA but also re-aggravated by dose increase or re-administration of 5-ASA were reviewed. The patients were newly diagnosed with UC, started 5-ASA and developed an exacerbation in approximately 2 to 3 weeks. They did not appear to have systemic allergic reactions. Seven of the 8 patients had a high fever. Three of 5 patients who undertook total colonoscopy showed right-side-dominant colitis. These findings suggest clinical characteristics in this condition. Further assessment of clinical and endoscopic features in more cases is necessary for establishing diagnostic criteria and understanding underlying mechanisms in those cases where 5-ASA aggravates the colitis.

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Secondary loss‐of‐response associated with intolerance to Janus kinase inhibitor in a boy with ulcerative colitis
Yuka Minoura, Koji Yokoyama, Yuko Okada, Shinya Fukuda, Hideki Kumagai
Pediatrics International.2025;[Epub] CrossRef
Krill Oil and Its Bioactive Components as a Potential Therapy for Inflammatory Bowel Disease: Insights from In Vivo and In Vitro Studies
Yingying Liu, Ainsley M. Robinson, Xiao Qun Su, Kulmira Nurgali
Biomolecules.2024; 14(4): 447. CrossRef
Ziziphus jujuba Miller Ethanol Extract Restores Disrupted Intestinal Barrier Function via Tight Junction Recovery and Reduces Inflammation
Ye Yang, Min Kim, Ho Lee, Won-Yung Lee, Ju-Hye Yang, Hun Kim, Min Shim, Ji Heo, Jae Son, Woo Kim, Gon Kim, Hu-Jang Lee, Young-Woo Kim, Kwang Kim, Kwang Park
Antioxidants.2024; 13(5): 575. CrossRef
Characteristics of Mucosa-Associated Microbiota in Ulcerative Colitis Patients with 5-Aminosalicylic Acid Intolerance
Hiroshi Matsumoto, Momoyo Sasahira, Tei Tei Go, Shogen Yo, Takehiro Ninomiya, Motoyasu Osawa, Osamu Handa, Eiji Umegami, Ryo Inoue, Akiko Shiotani
Biomedicines.2024; 12(9): 2125. CrossRef
Phage cocktail inhibits inflammation and protects the integrity of the intestinal barrier in dextran sulfate sodium-induced colitis mice model
Jiazhen Xu, Ting Liu, Yingchun Shao, Qing Liu, Zongying Zhang, Yang Yuan, Shuangshuang Zhang, Yanhong Wang, Li Sun, Sha Zhou, Minglu Hao, Haoren Xiu, Xiaohui Xing, Dongming Xing
Microbial Pathogenesis.2024; 197: 107053. CrossRef
Risk factors for intolerance of oral 5‐aminosalicylic acid preparations in pediatric ulcerative colitis
Naoki Abe, Naomi Iwata, Ryuhei Yasuoka, Daisuke Nishida, Asami Oohara, Haruna Nakaseko, Shiro Sugiura, Shinji Kawabe
Pediatrics International.2023;[Epub] CrossRef
Significance of 5-Aminosalicylic Acid Intolerance in the Clinical Management of Ulcerative Colitis
Yohei Mikami, Junya Tsunoda, Shohei Suzuki, Ichiro Mizushima, Hiroki Kiyohara, Takanori Kanai
Digestion.2023; 104(1): 58. CrossRef
APE1/Ref-1 as a Therapeutic Target for Inflammatory Bowel Disease
Lauren Sahakian, Ainsley M. Robinson, Linda Sahakian, Rhian Stavely, Mark R. Kelley, Kulmira Nurgali
Biomolecules.2023; 13(11): 1569. CrossRef

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Endoscopy

Magnified single-balloon enteroscopy in the diagnosis of intestinal follicular lymphoma: a case series: Kenichiro Takahashi, Shigeki Bamba, Masahiro Kawahara, Atsushi Nishida, Osamu Inatomi, Masaya Sasaki, Tomoyuki Tsujikawa, Ryoji Kushima, Mitsushige Sugimoto, Katsuyuki Kitoh, Akira Andoh; Intest Res 2018;16(4):628-634. Published online October 10, 2018; DOI: https://doi.org/10.5217/ir.2018.00003

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The objective of this study was to evaluate the magnified endoscopic findings in the diagnosis of follicular lymphoma in the small intestine in comparison with those of intestinal follicular lymphoma and lymphangiectasia. Four patients with follicular lymphoma and 3 with lymphangiectasia in the small intestine were retrospectively analyzed. A prototype magnifying singleballoon enteroscope was used. The findings of the intestinal follicular lymphoma and lymphangiectasia were retrospectively analyzed to determine the magnified endoscopic findings of follicular lymphoma in the small intestine. Opaque white granules were observed in 3 of the 4 patients with follicular lymphoma. Magnified narrow-band imaging (NBI) of the opaque white granules showed stretched microvessels, which had a diminutive tree-like appearance. The remaining patient had no opaque white granules and only displayed whitish villi. Magnified NBI observation of the whitish villi revealed the absence of marginal villus epithelium, which was confirmed by histology. The magnified NBI enteroscopy revealed the diminutive tree-like appearance on the opaque white granules and the absence of marginal villus epithelium of the whitish villi in intestinal follicular lymphoma. These findings may be useful in diagnosing follicular lymphoma.

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A case of intestinal T‐cell lymphoma, not otherwise specified, that showed characteristic findings by magnified endoscopy combined with narrow‐band imaging
Yuki Hirose, Satoshi Saito, Takanori Nishiguchi, Dai Yamazaki, Tsubasa Tateishi, Yuuichi Saito, Yukiko Komeno, Makoto Kodama, Shiho Iwamoto, Masayuki Fukata, Minako Sako
DEN Open.2024;[Epub] CrossRef
Discordance Rate and Risk Factor of Other Diagnostic Modalities for Small Bowel Tumors Detected by Device-Assisted Enteroscopy: A Korean Association for the Study of Intestinal Disease (KASID) Multicenter Study
Jihye Park, Jin Su Kim, Joo Hye Song, Kwangwoo Nam, Seong-Eun Kim, Eui Sun Jeong, Jae Hyun Kim, Seong Ran Jeon
Gut and Liver.2024; 18(4): 686. CrossRef
Predictive factors for the progression of primary localized stage small-bowel follicular lymphoma
Akihiko Sumioka, Shiro Oka, Issei Hirata, Sumio Iio, Akiyoshi Tsuboi, Hidehiko Takigawa, Ryo Yuge, Yuji Urabe, Kazuki Boda, Tomohiko Kohno, Hideharu Okanobu, Yasuhiko Kitadai, Koji Arihiro, Shinji Tanaka
Journal of Gastroenterology.2022; 57(9): 667. CrossRef

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IBD

Enteric infections complicating ulcerative colitis: Dejan Micic, Ayal Hirsch, Namrata Setia, David T. Rubin; Intest Res 2018;16(3):489-493. Published online July 27, 2018; DOI: https://doi.org/10.5217/ir.2018.16.3.489

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Enteric infections have previously been postulated to play a role in the pathogenesis of inflammatory bowel disease (IBD), however, little evidence exists in the etiologic role of specific enteric infections in the development of IBD. When encountered in the setting of IBD, enteric infections pose a clinical challenge in management given the competing treatment strategies for infectious conditions and autoimmune disorders. Here we present the case of a young male with enteric infections complicating a new diagnosis of IBD. Our patient's initial clinical presentation included diagnoses of Klebsiella oxytoca isolation and Clostridium difficile infection. Directed therapies to include withdrawal of antibiotics and fecal microbiota transplantation were performed without resolution of clinical symptoms. Given persistence of symptoms and active colitis, the patient was diagnosed with ulcerative colitis (UC), requiring treatments directed at severe UC to include cyclosporine therapy. The finding of multiple enteric infections in a newly presenting patient with IBD is an unexpected finding that has treatment implications.

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Echinacea purpurea Polysaccharide Ameliorates Dextran Sulfate Sodium-Induced Colitis by Restoring the Intestinal Microbiota and Inhibiting the TLR4-NF-κB Axis
Fan-Hao Wei, Wen-Yin Xie, Pei-Sen Zhao, Wei Gao, Fei Gao
Nutrients.2024; 16(9): 1305. CrossRef
Inflammatory bowel disease complicated with rare pathogen infection
Jia-Heng Fang, Guo-Xiong Li
World Chinese Journal of Digestology.2023; 31(1): 8. CrossRef
Usefulness of Stool Multiplex Polymerase Chain Reaction Assays in Patients with Acute Diarrhea
Seo Hyun Kim, You Sun Kim, Seung Hyuk Kim, Won Eui Yoon, Hee Jun Myung, Jeong Seop Moon, Dong Hee Whang
The Korean Journal of Gastroenterology.2022; 79(3): 118. CrossRef
Animal unit hygienic conditions influence mouse intestinal microbiota and contribute to T-cell-mediated colitis
Mariana Cázares-Olivera, Dominika Miroszewska, Lili Hu, Jacek Kowalski, Ulla-Marjut Jaakkola, Seppo Salminen, Bin Li, Emrah Yatkin, Zhi Chen
Experimental Biology and Medicine.2022; 247(19): 1752. CrossRef
Gut Microbiota-Mediated NLRP12 Expression Drives the Attenuation of Dextran Sulphate Sodium-Induced Ulcerative Colitis by Qingchang Wenzhong Decoction
Zhongmei Sun, Wenjing Pei, Yi Guo, Zhibin Wang, Rui Shi, Xiaowei Chen, Xingjie Zhao, Chen Chen, Jiali Liu, Xiang Tan, Wenjing Yuan, Tangyou Mao
Evidence-Based Complementary and Alternative Medicine.2019; 2019: 1. CrossRef
Intestinal autophagy links psychosocial stress with gut microbiota to promote inflammatory bowel disease
Shu-Ling Wang, Bo-Zong Shao, Sheng-Bing Zhao, Xin Chang, Pei Wang, Chao-Yu Miao, Zhao-Shen Li, Yu Bai
Cell Death & Disease.2019;[Epub] CrossRef

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IBD

Successful remission of ulcerative colitis flare-up during pregnancy with adsorptive granulomonocytapheresis plus tacrolimus: Tomoyoshi Shibuya, Keiichi Haga, Masato Kamei, Koki Okahara, Shoko Ito, Masahito Takahashi, Osamu Nomura, Takashi Murakami, Masae Makino, Tomohiro Kodani, Dai Ishikawa, Naoto Sakamoto, Taro Osada, Tatsuo Ogihara, Sumio Watanabe, Akihito Nagahara; Intest Res 2018;16(3):484-488. Published online July 27, 2018; DOI: https://doi.org/10.5217/ir.2018.16.3.484

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Ulcerative colitis (UC) is 1 of the 2 major phenotypes of chronic inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world with debilitating symptoms that impair function and quality of life. Further, IBD often affects women during childbearing age. Indeed, UC activity frequently increases during pregnancy, and the medications used to induce remission may adversely affect the health of the mother and the unborn child. We report successful induction of a remission in a UC case who experienced a flare-up in the first trimester of pregnancy. Upon relapse, she was treated with steroids and adsorptive granulomonocytapheresis (GMA) with the Adacolumn plus tacrolimus. This combination therapy induced a stable remission that was maintained during her entire pregnancy. She gave birth to a healthy child at 36 weeks of pregnancy with no maternal or fetal complications. Our experience indicates that GMA, as a non-drug therapeutic intervention with a favorable safety profile, plus tacrolimus might be a relevant treatment option for patients with active IBD during pregnancy. A future study of a large cohort of pregnant patients should strengthen our findings.

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Adsorptive cytapheresis in ulcerative colitis: A non‐pharmacological therapeutic approach revisited
Filippo Vernia, Angelo Viscido, Giovanni Latella
Journal of Clinical Apheresis.2023; 38(6): 746. CrossRef
Apheresis: A cell-based therapeutic tool for the inflammatory bowel disease
Farah Yasmin, Hala Najeeb, Unaiza Naeem, Abdul Moeed, Thoyaja Koritala, Salim Surani
World Journal of Clinical Cases.2022; 10(21): 7195. CrossRef
Reproductive Health in IBD Patients
Sanket Patel, Haleh Vaziri
Current Treatment Options in Gastroenterology.2021; 19(2): 237. CrossRef
Selective granulocyte and monocyte apheresis in inflammatory bowel disease: Its past, present and future
Xiu-Li Chen, Jing-Wei Mao, Ying-De Wang
World Journal of Gastrointestinal Pathophysiology.2020; 11(3): 43. CrossRef
Women’s Health and Ulcerative Colitis
Kindra Clark-Snustad, Madalina Butnariu, Anita Afzali
Gastroenterology Clinics of North America.2020; 49(4): 769. CrossRef

10,748 View
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IBD

A case of ulcerative colitis presenting with cerebral venous thrombosis: Junghwan Lee, Sung Wook Hwang, Jinhee Lee, Kyung Hwa Jung, Ha Il Kim, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang; Intest Res 2018;16(2):306-311. Published online April 30, 2018; DOI: https://doi.org/10.5217/ir.2018.16.2.306

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Patients with inflammatory bowel disease (IBD) have been reported to have an increased risk of thromboembolism. Cerebral venous thrombosis (CVT) is a rare but serious extraintestinal manifestation of IBD. Due to its highly variable manifestation and low incidence, CVT is not usually readily recognized by physicians. Herein, we report a case of a 35-year-old male presenting with CVT associated with ulcerative colitis (UC). The patient was admitted with chief complaints of bloody diarrhea that had started 3 days prior. Sigmoidoscopy showed hyperemic and edematous mucosa, friability, and shallow ulcers from the sigmoid colon to the rectum suggestive of IBD. Three days later, the patient started complaining of a headache, and gradually developed a decreased level of consciousness. Magnetic resonance imaging of the brain revealed CVT with hemorrhagic infarctions. An angiogram was obtained to evaluate the extent of CVT, and anticoagulation therapy was initiated with intravenous heparin. During hospitalization, he was diagnosed with UC and treated with 5-aminosalicylic acid. After discharge, the patient was recovered without neurological deficit, and remission of UC was also obtained. The presence of headache or acute worsening of neurological status in a patient with IBD should alert the health professionals about the possibility of CVT.

Citations

Citations to this article as recorded by

Digit Necrosis After Hand Surgery in Pregnancy: A Case Report
Natalia Ziolkowski, Jana Dengler, Cory S Goldberg
Plastic Surgery Case Studies.2021;[Epub] CrossRef
Cerebral venous thrombosis as presenting manifestation of inflammatory bowel disease (IBD)
Katie Stamp, Alison Pattinson, Paul Maliakal, Thekootu Nandakumar, Shaji Sebastian
GastroHep.2019; 1(1): 45. CrossRef

8,058 View
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2 Web of Science
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IBD

Hyperbaric oxygen therapy for pyoderma gangrenosum associated with ulcerative colitis: Hyun Il Seo, Hyun-Ju Lee, Koon Hee Han; Intest Res 2018;16(1):155-157. Published online January 18, 2018; DOI: https://doi.org/10.5217/ir.2018.16.1.155

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Pyoderma gangrenosum (PG), an ulcerating skin condition, is rare in patients with ulcerative colitis (UC). We report a case of successful treatment of PG in a patient with UC using hyperbaric oxygen therapy (HBOT). The patient had UC that was in remission following treatment with mesalazine and azathioprine therapy. After visiting an orthopedic clinic, the patient opted for treatment with antibiotics and daily dressing of the ulcerative skin lesions, while azathioprine was discontinued. However, the lesions did not improve. Two months later, the patient visited a dermatologist who diagnosed the lesions as PG, and he was admitted to our unit. Surgical debridement and HBOT were performed by a plastic surgeon in the emergency department. After 3 months of HBOT and topical treatment, the patient's PG completely resolved. His UC was still in remission with mesalazine alone. HBOT may be an effective and safe alternative treatment for PG associated with UC, particularly in patients in whom anti-tumor necrosis factor agents are unnecessary.

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The new insights of hyperbaric oxygen therapy: focus on inflammatory bowel disease
Leilei Chen, Yan Wang, Huihui Zhou, Yi Liang, Fengqin Zhu, Guangxi Zhou
Precision Clinical Medicine.2024;[Epub] CrossRef
Emerging Indications for Hyperbaric Oxygen Treatment: Registry Cohort Study
Hideaki L Tanaka, Judy R Rees, Ziyin Zhang, Judy A Ptak, Pamela M Hannigan, Elaine M Silverman, Janet L Peacock, Jay C Buckey
Interactive Journal of Medical Research.2024; 13: e53821. CrossRef
EFICÁCIA DA OXIGENOTERAPIA HIPERBÁRICA NO TRATAMENTO DE PIODERMA GANGRENOSO
Ana Júllia Almeida Ferreira, Natally Macedo Torrente, Pedro Paulo Custódio Martinez Sacchi, Poliana Pezzotto
RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218.2024; 5(9): e595755. CrossRef
Treatment of Pyoderma Gangrenosum With Mycophenolate and Hyperbaric Oxygen Therapy: A Case Report and Literature Review
Subo Dey, Nirali Sanghavi, Amy Wasserman, Kausik Kar
Cureus.2023;[Epub] CrossRef
Efficacy and safety evaluation of hyperbaric oxygen therapy for patients with ulcerative colitis
Wei Wang, Ying He, Dou Wen, Shangshang Jiang, Xiaodong Zhao
Medicine.2021; 100(1): e23966. CrossRef
Adjunctive Hyperbaric Oxygen Therapy in Refractory Crohn’s Disease: An Observational Study
Marley R. Feitosa, Rogério S. Parra, Vanessa F. Machado, Gustavo N. Vilar, Jussara C. Aquino, José J. R. Rocha, Paulo G. Kotze, Omar Féres, Chiara Ricci
Gastroenterology Research and Practice.2021; 2021: 1. CrossRef
The role of hyperbaric oxygen therapy in inflammatory bowel disease
Xin Wu, Tian-Yu Liang, Zhong Wang, Gang Chen
Medical Gas Research.2021; 11(2): 66. CrossRef
Giant pyoderma gangrenosum in a patient with ulcerative colitis
Ruixian Niu, Jiangtao Zheng, Dongmei Ding, Weian Kuang, Fengyan Lu, Xunguo Yin
Medicine.2020; 99(6): e18795. CrossRef
Development of an International, Multicenter, Hyperbaric Oxygen Treatment Registry and Research Consortium: Protocol for Outcome Data Collection and Analysis
Nicole P Harlan, Judy A Ptak, Judy R Rees, Devin R Cowan, Abigail M Fellows, Judith A Kertis, Pamela M Hannigan, Janet L Peacock, Jay C Buckey
JMIR Research Protocols.2020; 9(8): e18857. CrossRef
Post-surgical pyoderma gangrenosum of the breast: needs for early diagnosis and right therapy
Giorgia Guaitoli, Federico Piacentini, Claudia Omarini, Alessia Andreotti, Enza Palma, Simona Papi, Chiara De Pietri, Andrea Conti, Stefano Cascinu, Giovanni Tazzioli
Breast Cancer.2019; 26(4): 520. CrossRef
Atypical wounds. Best clinical practice and challenges
Kirsi Isoherranen, Julie Jordan O'Brien, Judith Barker, Joachim Dissemond, Jürg Hafner, Gregor B. E. Jemec, Jivko Kamarachev, Severin Läuchli, Elena Conde Montero, Stephan Nobbe, Cord Sunderkötter, Mar Llamas Velasco
Journal of Wound Care.2019; 28(Sup6): S1. CrossRef
Pyoderma Gangrenosum: What Do We Know Now?
Fatima McKenzie, Megan Arthur, Alex G. Ortega-Loayza
Current Dermatology Reports.2018; 7(3): 147. CrossRef
Pyoderma gangrenosum – an interdisciplinary approach to the disease
Aleksandra Kapuśniak, Aleksandra Czachor, Grażyna Wąsik
Medical Science Pulse.2018; 12(4): 61. CrossRef

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IBD

Duodenal amyloidosis secondary to ulcerative colitis: Seung Woon Park, Sam Ryong Jee, Ji Hyun Kim, Sang Heon Lee, Jin Won Hwang, Ji Geon Jang, Dong Woo Lee, Sang Yong Seol; Intest Res 2018;16(1):151-154. Published online January 18, 2018; DOI: https://doi.org/10.5217/ir.2018.16.1.151

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Amyloidosis is defined as the extracellular deposition of non-branching fibrils composed of a variety of serum-protein precursors. Secondary amyloidosis is associated with several chronic inflammatory conditions, such as rheumatologic or intestinal diseases, familial Mediterranean fever, or chronic infectious diseases, such as tuberculosis. Although the association of amyloidosis with inflammatory bowel disease is known, amyloidosis secondary to ulcerative colitis (UC) is rare. A 36-year-old male patient with a 15-year history of UC presented with nausea, vomiting, and abdominal pain. He had been treated with infliximab for 6 years. At the time of admission, he had been undergoing treatment with mesalazine and adalimumab since the preceding 5 months. Esophagogastroduodenoscopy showed mucosal erythema, edema, and erosions with geographic ulcers at the 2nd and 3rd portions of the duodenum. Duodenal amyloidosis was diagnosed using polarized light microscopy and Congo red stain. Monoclonal gammopathy was not detected in serum and urine tests, while the serum free light chain assay result was not specific. An increase in plasma cells in the bone marrow was not found. Secondary amyloidosis due to UC was suspected. The symptoms were resolved after glucocorticoid therapy.

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Gastrointestinal amyloidosis in a 50‐year‐old patient with miliary tuberculosis: A case report
Sameer Abdul Rauf, Hussain Haider Shah, Rahul Khatri, Mansoor Ul Haq, Tirth Dave, Javaria Parwez Ali, Syed Khizar Ali
Clinical Case Reports.2024;[Epub] CrossRef
Therapeutic effects of biological treatments on AA amyloidosis associated with inflammatory bowel disease: a case report and literature review
Marouf Alhalabi, Kamal Alaa Eddin, Ahmad Abbas
European Journal of Gastroenterology & Hepatology.2023; 35(11): 1298. CrossRef
Rheumatoid arthritis: Extra-articular manifestations and comorbidities
Fabiana Assunta Figus, Matteo Piga, Irene Azzolin, Rebecca McConnell, Annamaria Iagnocco
Autoimmunity Reviews.2021; 20(4): 102776. CrossRef
Specific Clinical and Morphological Characteristics of Amyloidosis of the Stomach and Duodenum
Z. V. Gioeva, L. M. Mikhaleva
Journal of Anatomy and Histopathology.2019; 8(1): 39. CrossRef
Morphological and Immunohistochemical Characteristics of Experimental Mandibular Fractures Healing Process
A. A. Matchin, A. A. Stadnikov, E. V. Nosov, S. Kh. Kiriakidi
Journal of Anatomy and Histopathology.2019; 8(1): 44. CrossRef
Secondary, AA, Amyloidosis
Riccardo Papa, Helen J. Lachmann
Rheumatic Disease Clinics of North America.2018; 44(4): 585. CrossRef

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IBD

A case of pemphigus vulgaris associated with ulcerative colitis: Joo Wan Seo, Jongha Park, Jin Lee, Mi Young Kim, Hyun Ju Choi, Heui Jeong Jeong, Ji Woon Lee, So Young Jung, Woo Kyeong Kim; Intest Res 2018;16(1):147-150. Published online January 18, 2018; DOI: https://doi.org/10.5217/ir.2018.16.1.147

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Pemphigus vulgaris is an autoimmune bullous disorder characterized by the production of autoantibodies against the intercellular space of the epithelium. It has rarely been reported in association with inflammatory bowel disease. Ulcerative colitis is one of the forms of inflammatory bowel disease. A 62-year-old woman who had been treated for ulcerative colitis for 16 years developed pruritic bullae on the skin of her face and body. Histological findings and direct immunofluorescence examination of the skin showed pemphigus vulgaris. She was treated with systemic steroids, mesalazine, and azathioprine. Her cutaneous lesions have remained in remission and her ulcerative colitis has remained well-controlled. The relationship between pemphigus vulgaris and ulcerative colitis is unclear. An autoimmune response has been suspected in the pathogenesis of ulcerative colitis. Pemphigus vulgaris is also associated with an autoimmune mechanism. To our knowledge, this is the first case of ulcerative colitis associated with pemphigus vulgaris reported in Korea. The association may be causal.

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Autoimmune pemphigus: difficulties in diagnosis and the molecular mechanisms underlying the disease
Olga Simionescu, Sorin Ioan Tudorache
Frontiers in Immunology.2025;[Epub] CrossRef
Persistent Scattered Pustules: Vesiculopustular IgA Pemphigus Arising in a Patient With Ulcerative Colitis
Melissa M. Warne, Matthew F. Helm, Andrew Gaddi, Raminder Grover
The American Journal of Dermatopathology.2023; 45(5): 350. CrossRef
Cell-Matrix Interactions Contribute to Barrier Function in Human Colon Organoids
James Varani, Shannon D. McClintock, Muhammad N. Aslam
Frontiers in Medicine.2022;[Epub] CrossRef
Cutaneous Manifestations of Inflammatory Bowel Disease: A Basic Overview
Kyla Pagani, Danitza Lukac, Aashni Bhukhan, Jean S. McGee
American Journal of Clinical Dermatology.2022; 23(4): 481. CrossRef
Deep pemphigus (pemphigus vulgaris, pemphigus vegetans and paraneoplastic pemphigus) in dogs, cats and horses: a comprehensive review
Heng L. Tham, Keith E. Linder, Thierry Olivry
BMC Veterinary Research.2020;[Epub] CrossRef

7,826 View
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IBD

Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis: Kosaku Nanki, Shinta Mizuno, Katsuyoshi Matsuoka, Keiko Ono, Shinya Sugimoto, Hiroki Kiyohara, Mari Arai, Moeko Nakashima, Kozue Takeshita, Keiichiro Saigusa, Mitsutoshi Senoh, Tadashi Fukuda, Makoto Naganuma, Haru Kato, Wataru Suda, Masahira Hattori, Takanori Kanai; Intest Res 2018;16(1):142-146. Published online January 18, 2018; DOI: https://doi.org/10.5217/ir.2018.16.1.142

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Fecal microbiota transplantation (FMT) has been reported as a safe and effective therapy in patients with refractory and recurrent Clostridium difficile infection (CDI). FMT has also been reported as a promising therapy in patients with ulcerative colitis (UC). Both, CDI and UC, are believed to be caused by dysbiosis, such as altered compositions or decreased diversity of the intestinal microbiota. This report describes a patient with UC in remission with a second recurrent episode of CDI, who was treated with FMT. A single FMT performed via colonoscopy completely resolved the patient's diarrhea and eradicated C. difficile bacteriologically without any severe complications. Molecular biological analysis of the patient's fecal microbiota showed that FMT could dramatically change the altered composition of intestinal microbiota and restore its diversity. Despite the restoration of the intestinal microbiota, FMT could not prevent a relapse of UC in this patient. However, it improved the intestinal symptoms of CDI and could prevent further recurrences of CDI.

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Impact of Clostridioides difficile Infection on Clinical Outcomes in Hospitalized IBD Patients and the Role of Fecal Microbiota Transplantation: A Retrospective Cohort Study
Puo‐Hsien Le, Chyi‐Liang Chen, Chia‐Jung Kuo, Pai‐Jui Yeh, Chien‐Chang Chen, Yi‐Ching Chen, Cheng‐Tang Chiu, Hao‐Tsai Cheng, Yung‐Kuan Tsou, Yu‐Bin Pan, Cheng‐Hsun Chiu
The Kaohsiung Journal of Medical Sciences.2025;[Epub] CrossRef
Comparative Efficacy of Fecal Microbiota Transplantation in Treating Refractory or Recurrent Clostridioides difficile Infection among Patients with and without Inflammatory Bowel Disease: A Retrospective Cohort Study
Jing-Han Chen, Cheng-Hsun Chiu, Chien-Chang Chen, Yi-Ching Chen, Pai-Jui Yeh, Chia-Jung Kuo, Cheng-Tang Chiu, Hao-Tsai Cheng, Yu-Bin Pan, Puo-Hsien Le
Biomedicines.2024; 12(7): 1396. CrossRef
Case report: Fecal microbiota transplant for Clostridium difficile infection in a pregnant patient with acute severe ulcerative colitis
Hanyu Wang, Feihong Deng, Min Luo, Xuehong Wang
Frontiers in Immunology.2024;[Epub] CrossRef
The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease
Loris Riccardo Lopetuso, Sara Deleu, Lihi Godny, Valentina Petito, Pierluigi Puca, Federica Facciotti, Harry Sokol, Gianluca Ianiro, Luca Masucci, Maria Abreu, Iris Dotan, Samuel Paul Costello, Ailsa Hart, Tariq H Iqbal, Sudarshan Paramsothy, Maurizio San
Gut.2023; 72(9): 1642. CrossRef
Fecal microbiota transplantation as therapy for recurrent Clostridioides difficile infection is associated with amelioration of delirium and accompanied by changes in fecal microbiota and the metabolome
Kazuyoshi Gotoh, Yoshihiko Sakaguchi, Haru Kato, Hayato Osaki, Yasutaka Jodai, Mitsutaka Wakuda, Akira Také, Shunji Hayashi, Eri Morita, Takehiko Sugie, Yoichiro Ito, Naoki Ohmiya
Anaerobe.2022; 73: 102502. CrossRef
Management of Clostridioides difficile infection in patients with inflammatory bowel disease
Sahil Khanna
Intestinal Research.2021; 19(3): 265. CrossRef
Gut microbiota in ulcerative colitis: insights on pathogenesis and treatment
Xiao Yan Guo, Xin Juan Liu, Jian Yu Hao
Journal of Digestive Diseases.2020; 21(3): 147. CrossRef
RecurrentClostridium difficileInfection: Risk Factors, Treatment, and Prevention
Jung Hoon Song, You Sun Kim
Gut and Liver.2019; 13(1): 16. CrossRef
Current Status of Clostridium Difficile Infection
Akira Andoh, Shigeki Bamba
Nippon Daicho Komonbyo Gakkai Zasshi.2018; 71(10): 456. CrossRef

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A case of celiac disease with neurologic manifestations misdiagnosed as amyotrophic lateral sclerosis: Hyoju Ham, Bo-In Lee, Hyun Jin Oh, Se Hwan Park, Jin Su Kim, Jae Myung Park, Young Seok Cho, Myung-Gyu Choi; Intest Res 2017;15(4):540-542. Published online October 23, 2017; DOI: https://doi.org/10.5217/ir.2017.15.4.540

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Celiac disease (CD) is an immune-mediated enteropathy and is a rare disease in Asia, including in Korea. However, the ingestion of wheat products, which can act as a precipitating factor of CD, has increased rapidly. CD is a common cause of malabsorption, but many patients can present with various atypical manifestations as first presented symptoms, including anemia, osteopenia, infertility, and neurological symptoms. Thus, making a diagnosis is challenging. We report a case of CD that mimicked amyotrophic lateral sclerosis (ALS). The patient was a sexagenary man with a history of progressive motor weakness for 2 years. He was highly suspected as having ALS. During evaluation of his neurological symptoms, esophagogastroduodenoscopy (EGD) was performed because he had experienced loose stools and weight loss for the previous 7 months. On EGD, the duodenal mucosa appeared smooth. A biopsy revealed severe lymphoplasma cell infiltration with flattened villi. His serum endomysial antibody (immunoglobulin A) titer was 1:160 (reference, <1:40). Finally, he was diagnosed as having CD, and a gluten-free diet was immediately begun. At a 4-month follow-up, his weight and the quality of his stool had improved gradually, and the neurological manifestations had not progressed.

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Prevalence of genetic markers of celiac disease in different populations
G. N. Yankina, E. I. Kondratieva, E. V. Loshkova
Archives of Pediatrics and Pediatric Surgery.2025; 2(3): 27. CrossRef
The Role of Gut Microbiota-derived Short Chain Fatty Acids in Amyotrophic Lateral Sclerosis
Mohamed J. Saadh, Shahad Mohammed Dhiaa, Pooja Bansal, Hasan Khalid Dabis, Ashu Katyal, Vivek Saraswat, Azher Abdulmutaleb Ibrahim, Radi Usama Kadem, Mohammed Ubaid
Current Behavioral Neuroscience Reports.2025;[Epub] CrossRef
Celiac disease - a pluripathological model in pediatric practice
Vasile Valeriu Lupu, Maria Oana Sasaran, Elena Jechel, Iuliana Magdalena Starcea, Ileana Ioniuc, Adriana Mocanu, Solange Tamara Rosu, Valentin Munteanu, Alin Horatiu Nedelcu, Ciprian Danielescu, Delia Lidia Salaru, Anton Knieling, Ancuta Lupu
Frontiers in Immunology.2024;[Epub] CrossRef
The presence and clinical significance of autoantibodies in amyotrophic lateral sclerosis: a narrative review
Shen Liu, Ye Hong, Bian-Rong Wang, Zi-Qiao Wei, Hong-Dong Zhao, Teng Jiang, Ying-Dong Zhang, Jian-Quan Shi
Neurological Sciences.2024; 45(9): 4133. CrossRef
Celiac Disease Genetics, Pathogenesis, and Standard Therapy for Japanese Patients
Tasuku Tamai, Kenji Ihara
International Journal of Molecular Sciences.2023; 24(3): 2075. CrossRef
A Gut Feeling in Amyotrophic Lateral Sclerosis: Microbiome of Mice and Men
Sarah Martin, Carolina Battistini, Jun Sun
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef
Protective role of IGF-1 and GLP-1 signaling activation in neurological dysfunctions
Sonalika Bhalla, Sidharth Mehan, Andleeb Khan, Muneeb U. Rehman
Neuroscience & Biobehavioral Reviews.2022; 142: 104896. CrossRef
Target Metabolites to Slow Down Progression of Amyotrophic Lateral Sclerosis in Mice
Destiny Ogbu, Yongguo Zhang, Katerina Claud, Yinglin Xia, Jun Sun
Metabolites.2022; 12(12): 1253. CrossRef
Total serum immunoglobulin A in ALS
Jesse Crayle, Mai Elmallah, John Sleasman, Richard Bedlack
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration.2021; 22(1-2): 61. CrossRef
Underutilization of diagnostic assays for celiac disease in Korea
Rihwa Choi, Sang Gon Lee, Eun Hee Lee
Journal of Clinical Laboratory Analysis.2021;[Epub] CrossRef
Aberrant enteric neuromuscular system and dysbiosis in amyotrophic lateral sclerosis
Yongguo Zhang, Destiny Ogbu, Shari Garrett, Yinglin Xia, Jun Sun
Gut Microbes.2021;[Epub] CrossRef
Premalignant Lesions of the Small Intestine
Su Hwan Kim, Ji Won Kim
Journal of Digestive Cancer Reports.2021; 9(2): 60. CrossRef
The effects of diet and sex in amyotrophic lateral sclerosis
J.A. Pape, J.H. Grose
Revue Neurologique.2020; 176(5): 301. CrossRef
“ALS reversals”: demographics, disease characteristics, treatments, and co-morbidities
Daniel Harrison, Paul Mehta, Michael A. van Es, Elijah Stommel, Vivian E. Drory, Beatrice Nefussy, Leonard H. van den Berg, Jesse Crayle, Richard Bedlack
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration.2018; 19(7-8): 495. CrossRef

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Steroid-refractory extensive enteritis complicated by ulcerative colitis successfully treated with adalimumab: Shinji Okabayashi, Taku Kobayashi, Tomohisa Sujino, Ryo Ozaki, Satoko Umeda, Takahiko Toyonaga, Eiko Saito, Masaru Nakano, Maria Carla Tablante, Shojiroh Morinaga, Toshifumi Hibi; Intest Res 2017;15(4):535-539. Published online October 23, 2017; DOI: https://doi.org/10.5217/ir.2017.15.4.535

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Extracolonic involvement of the gastrointestinal tract is extremely uncommon in ulcerative colitis (UC) and rarely found in the upper gastrointestinal tract or in postoperative cases since it typically responds to steroids. Here we report a case of UC complicated by extensive ileal inflammation that was refractory to steroids. A 20-year-old man was diagnosed with UC of typical pancolitis without ileal involvement and started treatment with pH-dependent mesalazine and oral prednisolone. Although his symptoms transiently resolved, the condition flared when the steroid dose was tapered down. Computed tomography revealed marked thickening of the ileal wall, and capsule endoscopy and balloon-assisted enteroscopy found diffuse mucosal inflammation with ulcers in the ileum. On the contrary, the inflammation in the colon and rectum was improving. Since the response to the second steroid course was inadequate, treatment with adalimumab and 6-mercaptopurine was initiated and finally achieved clinical and endoscopic remission. The investigation of small intestinal lesions is necessary in patients with UC whose clinical deterioration cannot be explained by colonic lesions.

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A case of relapsed pan-colonic ulcerative colitis accompanied with gastroduodenal lesions immediately after COVID-19
Katsuya Endo, Tomonori Satoh, Yuki Yoshino, Shiho Kondo, Yoko Kawakami, Daisuke Fukushi, Atsuko Takasu, Takayuki Kogure, Morihisa Hirota, Kennichi Satoh
Clinical Journal of Gastroenterology.2025;[Epub] CrossRef
Clinical Features and Therapeutic Outcomes of Post-colectomy Enteritis with Ulcerative Colitis
Yuki Horio, Motoi Uchino, Kazutoshi Hori, Kurando Kusunoki, Tomohiro Minagawa, Ryuichi Kuwahara, Kozo Kataoka, Naohito Beppu, Masataka Ikeda, Hiroki Ikeuchi
Journal of the Anus, Rectum and Colon.2021; 5(4): 405. CrossRef

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2 Crossref

Drug-induced eosinophilic pneumonia in a patient with Crohn's disease: diagnosis and treatment using fraction of exhaled nitric oxide: Jina Yeo, Hyun Sun Woo, Sang Min Lee, Yoon Jae Kim, Kwang An Kwon, Dong Kyun Park, Jung Ho Kim, Kyoung Oh Kim, Jun-Won Chung; Intest Res 2017;15(4):529-534. Published online October 23, 2017; DOI: https://doi.org/10.5217/ir.2017.15.4.529

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Oral 5-aminosalicylic acid agents (mesalazine and sulfasalazine) and azathioprine are the mainstays of treatment for inflammatory bowel disease. Reports of pulmonary toxicity induced by oral 5-aminosalicylic acid agents or azathioprine in patients with inflammatory bowel disease are very rare; to date, only 38 cases have been reported worldwide. We, herein, report a case involving a 26-year-old man who was diagnosed with eosinophilic pneumonia after using mesalazine and azathioprine for the treatment of Crohn's disease and recovered after treatment. We also found that the fraction of exhaled nitric oxide level was elevated in this patient. After treatment, the fraction of exhaled nitric oxide level decreased and the symptoms improved. The present case shows that fraction of exhaled nitric oxide is related to the disease activity and treatment effectiveness of druginduced eosinophilic pneumonia.

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Exploratory disproportionality analysis of potentially drug-induced eosinophilic pneumonia using United States Food and Drug Administration adverse event reporting system
Ashwin Kamath
Scientific Reports.2025;[Epub] CrossRef
Qualitative and quantitative study of intermolecular weak interactions for aminosalicylic acid isomers by terahertz spectroscopy
Yuan Tang, Zhi Li, Shan Tu, Yulai She, Yongying Gan
International Journal of Quantum Chemistry.2022;[Epub] CrossRef
Spontaneous resolution of focal eosinophilic myositis of the adductor pollicis complicated by lung lesions
Sayuri Yamashita, Hidenaga Kawasumi, Makiko Kimura, Mutsuto Tateishi
Modern Rheumatology Case Reports.2020; 4(1): 106. CrossRef
lncRNACNN3-206 activates intestinal epithelial cell apoptosis and invasion by sponging miR-212, an implication for Crohn's disease
Na Li, Rui-Hua Shi
World Journal of Gastroenterology.2020; 26(5): 478. CrossRef
Expression alteration of long non-coding RNAs and their target genes in the intestinal mucosa of patients with Crohn’s disease
Na Li, Ruihua Shi
Clinica Chimica Acta.2019; 494: 14. CrossRef
Mesalazin-induced eosinophilic pneumonia in a 15-year-old boy with ulcerative colitis
G. N. Yankinа, L. V. Gorlenko, E. V. Loshkova, E. I. Kondratyeva, E. Yu. Tuteva, A. A. Terenteva, V. A. Zhelev, E. V. Mikhalev, T. A. Shemyakinа, T. S. Krivonogova, N. A. Ryzhakova, E. V. Romanova
Bulletin of Siberian Medicine.2019; 18(3): 245. CrossRef
Oxidative Stress and Effect of Treatment on the Oxidation Product Decomposition Processes in IBD
Ewa Dudzińska, Magdalena Gryzinska, Katarzyna Ognik, Paulina Gil-Kulik, Janusz Kocki, Vladimir Jakovljevic
Oxidative Medicine and Cellular Longevity.2018;[Epub] CrossRef

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Fatal infections in older patients with inflammatory bowel disease on anti-tumor necrosis factor therapy: Way-Seah Lee, Najib Azmi, Ruey-Terng Ng, Sik-Yong Ong, Sasheela Sri La Ponnampalavanar, Sanjiv Mahadeva, Ida Hilmi; Intest Res 2017;15(4):524-528. Published online October 23, 2017; DOI: https://doi.org/10.5217/ir.2017.15.4.524

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Anti-tumor necrosis factor (anti-TNF) is highly effective in inflammatory bowel disease (IBD); however, it is associated with an increased risk of infections, particularly in older adults. We reviewed 349 patients with IBD, who were observed over a 12-month period, 74 of whom had received anti-TNF therapy (71 patients were aged <60 years and 3 were aged ≥60 years). All the 3 older patients developed serious infectious complications after receiving anti-TNFs, although all of them were also on concomitant immunosuppressive therapy. One patient developed disseminated tuberculosis, another patient developed cholera diarrhea followed by nosocomial pneumonia, while the third patient developed multiple opportunistic infections (Pneumocystis pneumonia, cryptococcal septicemia and meningitis, Klebsiella septicemia). All 3 patients died within 1 year from the onset of the infection(s). We recommend that anti-TNF, especially when combined with other immunosuppressive therapy, should be used with extreme caution in older adult patients with IBD.

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Infection toxicity assessment of tumor necrosis factor α inhibitors in the treatment of IBD: a real-world study based on the US food and drug administration adverse events reporting system (FAERS)
Qian Cheng, Zeyu Yao, Xuan Shi, Shupeng Zou, Yazheng Zhao, Mengling Ouyang, Minghui Sun
Expert Opinion on Drug Safety.2025; : 1. CrossRef
RATE OF INFECTION (TUBERCULOSIS) IN BRAZILIANS IBD PRIVATE PATIENTS: FOLLOW-UP 15 YEARS
Didia B CURY, Liana C B CURY, Ana C MICHELETTI, Rogério A OLIVEIRA, José J S GONÇALVES
Arquivos de Gastroenterologia.2024;[Epub] CrossRef
Cryptococcosis Associated With Biologic Therapy: A Narrative Review
Xin Li, Olivier Paccoud, Koon-Ho Chan, Kwok-Yung Yuen, Romain Manchon, Fanny Lanternier, Monica A Slavin, Frank L van de Veerdonk, Tihana Bicanic, Olivier Lortholary
Open Forum Infectious Diseases.2024;[Epub] CrossRef
Inflammatory bowel disease complicated with rare pathogen infection
Jia-Heng Fang, Guo-Xiong Li
World Chinese Journal of Digestology.2023; 31(1): 8. CrossRef
Pulmonary cryptococcosis after immunomodulator treatment in patients with Crohn’s disease: Three case reports
Yan-Fei Fang, Xiang-Han Cao, Ling-Ya Yao, Qian Cao
World Journal of Gastroenterology.2023; 29(4): 758. CrossRef
Systemic lupus erythematosus complicated by Crohn’s disease with rectovaginal fistula
Heng Yeh, Ren-Chin Wu, Wen-Sy Tsai, Chia-Jung Kuo, Ming-Yao Su, Cheng-Tang Chiu, Puo-Hsien Le
BMC Gastroenterology.2021;[Epub] CrossRef
Systematic review with meta‐analysis: biologics and risk of infection or cancer in elderly patients with inflammatory bowel disease
Daniele Piovani, Silvio Danese, Laurent Peyrin‐Biroulet, Georgios K. Nikolopoulos, Stefanos Bonovas
Alimentary Pharmacology & Therapeutics.2020; 51(9): 820. CrossRef
Safety of Biologic Therapy in Older Patients With Immune-Mediated Diseases: A Systematic Review and Meta-analysis
Nienke Z. Borren, Ashwin N. Ananthakrishnan
Clinical Gastroenterology and Hepatology.2019; 17(9): 1736. CrossRef
Improving Quality in the Care of Patients with Inflammatory Bowel Diseases
Matthew D Egberg, Ajay S Gulati, Ziad F Gellad, Gil Y Melmed, Michael D Kappelman
Inflammatory Bowel Diseases.2018; 24(8): 1660. CrossRef

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Behçet's disease with multiple splenic abscesses in a child: Kyung In Lim, Dong Hwa Yang, Eell Ryoo; Intest Res 2017;15(3):422-428. Published online June 12, 2017; DOI: https://doi.org/10.5217/ir.2017.15.3.422

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We report the case of a 5-year-old male patient with multiple aseptic splenic abscesses associated with Behçet's disease. The patient visited Gachon University Gil Hospital with fever, abdominal pain, and acute watery and bloody diarrhea, and reported a 2-year history of chronic abdominal pain and intermittent watery diarrhea. He was treated with antibiotics at a local clinic for fever and cervical lymph node swelling. Additionally, he had recurrent stomatitis. A colonoscopy showed multiple well-demarcated ulcerations throughout the colon, and abdominal computed tomography showed multiple splenic abscesses. Pathergy and HLA-B51 tests were positive. Investigations did not reveal any infectious organisms in the aspirate obtained via ultrasound-guided fine needle aspiration. After steroid treatment, all symptoms and multiple aseptic splenic abscesses resolved. However, oral ulcers, genital ulcers, and abdominal pain recurred after tapering the steroids. Infliximab treatment improved the patient's symptoms. However, 5 months after the treatment, the symptoms recurred. The treatment was changed to include adalimumab. Subsequently, the patient's symptoms resolved and colonoscopic findings improved. No recurrence was noted after 3 months of follow-up.

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Aseptic Abscess of the Spleen as an Antecedent Manifestation of Behçet’s Disease
Mohamed Jazeer, Diroji Antony, Mayurathan Pakkiyaretnam
Cureus.2023;[Epub] CrossRef
Treatment with Biologic Drugs in Pediatric Behçet’s Disease: A Comprehensive Analysis of the Published Data
Ezgi Deniz Batu, Seher Sener, Veysel Cam, Nuray Aktay Ayaz, Seza Ozen
BioDrugs.2023; 37(6): 813. CrossRef
Case report: Aseptic splenic abscesses in childhood-onset systemic lupus erythematosus
Shobashenee Sritharan, Peter Sie-Teck Lau, Kamilah Manan, Anand Mohan
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Successful management of a case of intestinal Behçet’s disease with a splenic abscess by intensified immunosuppressive therapy without splenectomy
Noriko Sato, Fumiya Yamaide, Ryohei Shibata, Taiji Nakano, Akiko Yamaide, Takeshi Saito, Naoki Shimojo
Modern Rheumatology Case Reports.2022; 6(2): 266. CrossRef
Adalimumab in the treatment of pediatric Behçet’s disease: case-based review
Dimitri Poddighe, Zaure Mukusheva, Kaisar Dauyey, Maikesh Assylbekova
Rheumatology International.2019; 39(6): 1107. CrossRef

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Telmisartan-induced sprue-like enteropathy: a case report and a review of patients using non-olmesartan angiotensin receptor blockers: Harshal Surendra Mandavdhare, Vishal Sharma, Kaushal K Prasad, Amit Kumar, Manish Rathi, Surinder S Rana; Intest Res 2017;15(3):419-421. Published online June 12, 2017; DOI: https://doi.org/10.5217/ir.2017.15.3.419

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Recent studies have identified sprue-like illness associated with the use of the antihypertensive agent olmesartan medoxomil. However, whether this condition is specific to the use of olmesartan or is associated with the use of drugs belonging to the class of “sartans” remains to be clarified. A 45-year-old woman with chronic kidney disease along with hypothyroidism and hypertension presented with chronic diarrhea and significant weight loss. Endoscopy of the upper gastrointestinal tract showed scalloping and grooving of the duodenum, and histopathological examination showed subtotal villous atrophy. She was on telmisartan for hypertension, which was discontinued. Subsequently, diarrhea ameliorated dramatically, and she regained weight. To our knowledge, this is the first study to report telmisartan-associated sprue-like enteropathy. Further, we have reviewed the cases of patients with sprue-like enteropathy caused by valsartan, irbesartan, and eprosartan.

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Ankur Gupta, Priyanka Jain, Latika Gupta
Indian Journal of Gastroenterology.2024; 43(3): 684. CrossRef
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Annalisa Schiepatti, Paolo Minerba, Michele Puricelli, Stiliano Maimaris, Giovanni Arpa, Federico Biagi, David S. Sanders
Alimentary Pharmacology & Therapeutics.2024; 59(4): 432. CrossRef
Olmesartan induced enteropathy affecting the entire gastrointestinal tract: a case report
N Van Horebeek, R Croes, A Vonck, E Colpaert
Acta Gastro Enterologica Belgica.2023; 86(1): 95. CrossRef
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Seo Yeon Yoo, Jihun Kim, Kee Wook Jung
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Tanner Storozuk, Ian Brown, Stephen Lagana, Maria Westerhoff, Namrata Setia, John Hart, Lindsay Alpert
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Severe cases of sprue‐like enteropathy associated with angiotensin receptor blockers other than olmesartan
Peter Malfertheiner, Chiara Formigoni
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Coexistence of ulcerative colitis and Sjögren's syndrome in a patient with Takayasu's arteritis and Hashimoto's thyroiditis: Hyun Woo Park, Hyun Seok Lee, Sejin Hwang, Han Sol Lee, Han-Ik Bae, Ghilsuk Yoon; Intest Res 2017;15(2):255-259. Published online April 27, 2017; DOI: https://doi.org/10.5217/ir.2017.15.2.255

Abstract PDF PubReader ePub

A 31-year-old woman with a 15-year history of Takayasu's arteritis (TA) and a 13-year history of Hashimoto's thyroiditis presented with hematochezia. She received a diagnosis of Sjögren's syndrome at 1 month before her visit to Kyungpook National University Medical Center. Her colonoscopic findings were compatible with a diagnosis of ulcerative colitis (UC). She was treated with oral mesalazine, and her hematochezia symptoms subsequently disappeared. The coexistence of UC and TA has been reported; however, reports on the coexistence of UC and Sjögren's syndrome, or of UC and Hashimoto's thyroiditis are rare. Although the precise etiologies of these diseases are unknown, their presence together suggests that they may have a common pathophysiologic background. Furthermore, in patients with autoimmune or vascular diseases, including TA, systemic manifestations should be assessed with consideration of inflammatory bowel diseases including UC in the presence of gastrointestinal symptoms such as diarrhea and hematochezia.

Citations

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Case report