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Inflammatory bowel diseases
Adherence to Asacol once daily versus divided regimen for maintenance therapy in ulcerative colitis: a prospective, multicenter, randomized study
Soo-Kyung Park, Sang Hyun Park, Chang Soo Eun, Geom Seog Seo, Jong Pil Im, Tae Oh Kim, Dong-Il Park
Intest Res 2019;17(3):349-356.   Published online February 8, 2019
DOI: https://doi.org/10.5217/ir.2018.00064
AbstractAbstract PDFPubReaderePub
Background/Aims
A once-daily (OD) regimen of 5-aminosalicylic acid (5-ASA) was easier to comply with than a divided daily (DD) regimen, and that treatment efficacy for ulcerative colitis (UC) was not affected by the dosing regimen. This study evaluated treatment adherence of OD and DD dosing in the Korean UC patients.
Methods
This study was a prospective, multicenter, randomized trial. UC patients were enrolled who have been in remission for more than 3 months. Patients were randomly assigned to the OD or DD group in a 1:1 ratio. The primary endpoint was adherence rate measured by tablet counts and self-reported adherence rate at 3, 6, 9, and 12 months. The relapse rate was measured at 1 year.
Results
Data from the 180 patients who were randomized were analyzed. Both self-reported adherence rate and adherence rate measured by tablet counts were not different at every points, including 1 year. The patients’ satisfaction of the OD group was higher than that of the DD group (P<0.001). At 1 year, 91.2% and 95.5% of patients in the OD group and DD group had maintained clinical remission, respectively (P=0.37).
Conclusions
The adherence rates were not different between the OD group and DD group. The patients’ satisfaction was higher in the OD group than in the DD group. 5-ASA OD dosing might have the same effect as DD for the maintenance of UC remission.

Citations

Citations to this article as recorded by  
  • Improving Medication Adherence Levels in Inflammatory Bowel Disease (IBD) Patients: A Narrative Evidence-Based Review
    Obreniokibo Amiesimaka, Kristina Aluzaite, Rhiannon Braund, Michael Schultz
    Patient Preference and Adherence.2024; Volume 18: 905.     CrossRef
  • Continuing or stopping 5‐aminosalicylates in patients with inflammatory bowel disease on anti‐TNF therapy: A nationwide population‐based study
    Jeongkuk Seo, Seonok Kim, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Dong‐Hoon Yang, Jeong‐Sik Byeon, Seung‐Jae Myung, Suk‐Kyun Yang, Ye‐Jee Kim, Byong Duk Ye
    Alimentary Pharmacology & Therapeutics.2024; 60(3): 389.     CrossRef
  • Researching Interventions to Improve Medication Adherence in Ulcerative Colitis Patients
    Mila Palma Pacheco, Flora Maria Lorenzo Fortes, Raquel Rocha dos Santos, Genoile Oliveira Santana Silva
    Journal of Coloproctology.2021; 41(01): 096.     CrossRef
  • Treatment of inflammatory bowel diseases: focusing on 5-aminosalicylates and immunomodulators
    You Sun Kim
    Journal of the Korean Medical Association.2021; 64(9): 596.     CrossRef
  • Living with ulcerative colitis in Germany: a retrospective analysis of dose escalation, concomitant treatment use and healthcare costs
    Axel Dignass, John Waller, Joseph C. Cappelleri, Irene Modesto, Agnes Kisser, Lena Dietz, Marco DiBonaventura, Robert Wood, Melanie May, Berit Libutzki, Danielle Bargo
    Journal of Medical Economics.2020; 23(4): 415.     CrossRef
  • Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis
    Alistair Murray, Tran M Nguyen, Claire E Parker, Brian G Feagan, John K MacDonald
    Cochrane Database of Systematic Reviews.2020;[Epub]     CrossRef
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  • 6 Web of Science
  • 6 Crossref
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Inflammatory bowel diseases
Ustekinumab is effective in biological refractory Crohn’s disease patients–regardless of approval study selection criteria
Sadik Saman, Martin Goetz, Judith Wendler, Nisar P. Malek, Jan Wehkamp, Thomas Klag
Intest Res 2019;17(3):340-348.   Published online May 31, 2019
DOI: https://doi.org/10.5217/ir.2019.00012
AbstractAbstract PDFPubReaderePub
Background/Aims
Ustekinumab is effective in active Crohn’s disease. In a retrospective study we assessed the clinical outcome in nonresponders to anti-tumor necrosis factor therapy, and/or conventional therapy and/or the α4β7-integrin inhibitor vedolizumab. As approval study populations do not always reflect the average “real world” patient cohort, we assessed weather patients who would not have qualified for approval studies show similar outcomes.
Methods
Forty-one patients with mild to severe active Crohn’s disease were treated with ustekinumab (intravenous 6 mg per kg/body weight) followed by subcutaneous ustekinumab (90 mg) at week 8. Depending on the clinical response maintenance therapy was chosen every 8 or 12 weeks. Clinical response was defined by Crohn’s Disease Activity Index (CDAI) decline, decline of stool frequency or clinical improvement. Inclusion criteria for approval studies were assessed.
Results
The 58.5% (24/41) showed clinical response to ustekinumab. The 58.3% of this group (14/24) achieved clinical remission. Clinical response correlated significantly with drop of stool frequency and improvement of CDAI score. The 39 out of 41 patients had no side effects and we observed no serious infections. About a third of our patients would not have met ustekinumab approval study criteria. However, patients who did not meet study criteria showed clinical improvement numerically in the same range compared to patients who would have qualified for approval studies.
Conclusions
Ustekinumab is effective, safe and well tolerated in a highly therapy refractory patient cohort. Even though a reasonable number of patients did not meet ustekinumab approval study criteria, approval study results seem to be representative to the overall patient cohort.

Citations

Citations to this article as recorded by  
  • Comparative effectiveness and safety of ustekinumab at different intervals of maintenance phase in inflammatory bowel disease: a systematic review and meta-analysis
    Yaqing Bai, Yinghao Sun, Qi He, Xiaoyin Bai, Hong Yang
    European Journal of Gastroenterology & Hepatology.2024; 36(4): 359.     CrossRef
  • Long-term real-world data of ustekinumab in Crohn’s disease: the Stockholm ustekinumab study
    Francesca Bello, Samer Muhsen, Haider Sabhan, Alexandra Borin, Fredrik Johansson, Charlotte Höög, Ole Forsberg, Christina Wennerström, Charlotte Söderman, Mikael Lördal, Sven Almer
    Therapeutic Advances in Gastroenterology.2024;[Epub]     CrossRef
  • Effectiveness and Safety of Ustekinumab in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
    Sailish Honap, Susanna Meade, Hajir Ibraheim, Peter M. Irving, Michael P. Jones, Mark A. Samaan
    Digestive Diseases and Sciences.2022; 67(3): 1018.     CrossRef
  • Systematic review with meta‐analysis: loss of response and requirement of ustekinumab dose escalation in inflammatory bowel diseases
    Hongsheng Yang, Bingyang Li, Qin Guo, Jian Tang, Bo Peng, Ni Ding, Miao Li, Qingfang Yang, Zicheng Huang, Na Diao, Xia Zhu, Jun Deng, Huili Guo, Pinjin Hu, Kang Chao, Xiang Gao
    Alimentary Pharmacology & Therapeutics.2022; 55(7): 764.     CrossRef
  • Clinically reversible ustekinumab-induced encephalopathy: case report and review of the literature
    Jordi Sarto, Berta Caballol, Joan Berenguer, Iban Aldecoa, Álvaro Carbayo, Daniel Santana, Ivan Archilla, Carles Gaig, Francesc Graus, Julián Panés, Albert Saiz
    Therapeutic Advances in Neurological Disorders.2022;[Epub]     CrossRef
  • Safety and Efficacy of Ustekinumab in the Treatment of Crohn Disease: A Systematic Review and Meta-analysis
    Mohammed Assem Khorshid, Ahmed Cordie, Sherief Abd-Elsalam
    Journal of Coloproctology.2022; 42(02): 178.     CrossRef
  • Real-World Evidence of the Effectiveness and Safety of Ustekinumab for the Treatment of Crohn’s Disease: Systematic Review and Meta-Analysis of Observational Studies
    Cristina Rubín de Célix, María Chaparro, Javier P. Gisbert
    Journal of Clinical Medicine.2022; 11(14): 4202.     CrossRef
  • Management of inflammatory bowel disease beyond tumor necrosis factor inhibitors: novel biologics and small-molecule drugs
    Soo-Young Na, You Sun Kim
    The Korean Journal of Internal Medicine.2022; 37(5): 906.     CrossRef
  • Prospective observational study on Stelara (ustekinumab) assessing effectiveness in Crohn’s disease (PROSE): a 16-week follow-up
    Anders Forss, Mark Clements, Pär Myrelid, Hans Strid, Charlotte Söderman, Agnieszka Wagner, David Andersson, Fredrik Hjelm, Ola Olén, Jonas F. Ludvigsson, Jonas Halfvarson
    Scandinavian Journal of Gastroenterology.2021; 56(6): 680.     CrossRef
  • Efficacy and tolerability of infliximab retreatment in patients with inflammatory bowel disease: a systematic review and meta-analysis
    Seungwon Yang, Siyoung Yang, Young Kwon Jo, Seungyeon Kim, Min Jung Chang, Junjeong Choi, Jae Hee Cheon, Yun Mi Yu
    Therapeutic Advances in Chronic Disease.2021;[Epub]     CrossRef
  • Treatment of inflammatory bowel diseases: focusing on biologic agents and new therapies
    Hyo Yeop Song, Geom Seog Seo
    Journal of the Korean Medical Association.2021; 64(9): 605.     CrossRef
  • Eficacia y seguridad de ustekinumab en la práctica clínica real. Estudio multicéntrico retrospectivo. Cohorte ARAINF
    Diego Casas Deza, Santiago García López, Miguel Lafuente Blasco, Raquel Vicente Lidón, Juan Nerín de la Puerta, Elena Peña Gonzalez, Yolanda Ber Nieto, Mara Charro Calvillo, María José Alcalá Escriche, Fernando Gomollón García, Maite Arroyo Villarino
    Gastroenterología y Hepatología.2020; 43(3): 126.     CrossRef
  • Effectiveness and safety of Ustekinumab for the treatment of Crohn’s disease in real-life experiences: a meta-analysis of observational studies
    Fabio Salvatore Macaluso, Marcello Maida, Marco Ventimiglia, Mario Cottone, Ambrogio Orlando
    Expert Opinion on Biological Therapy.2020; 20(2): 193.     CrossRef
  • Efficacy and safety of ustekinumab in real clinical practice. Retrospective multicentre study. ARAINF cohort
    Diego Casas Deza, Santiago García López, Miguel Lafuente Blasco, Raquel Vicente Lidón, Juan Nerín de la Puerta, Elena Peña Gonzalez, Yolanda Ber Nieto, Mara Charro Calvillo, María José Alcalá Escriche, Fernando Gomollón García, Maite Arroyo Villarino
    Gastroenterología y Hepatología (English Edition).2020; 43(3): 126.     CrossRef
  • Ustekinumab en enfermedad de Crohn: efectividad y seguridad en práctica clínica
    Cristina Saldaña Dueñas, María Rullán Iriarte, Alfonso Elosua González, Cristina Rodríguez Gutiérrez, Saioa Rubio Iturria, Óscar Nantes Castillejo
    Gastroenterología y Hepatología.2020; 43(9): 497.     CrossRef
  • Real‐world long‐term effectiveness of ustekinumab in Crohn's disease: results from the ENEIDA registry
    Marisa Iborra, Belén Beltrán, Agnes Fernández‐Clotet, Eva Iglesias‐Flores, Pablo Navarro, Montserrat Rivero, Ana Gutiérrez, Mónica Sierra‐Ausin, Francisco Mesonero, Rocío Ferreiro‐Iglesias, Joaquín Hinojosa, Xavier Calvet, Beatriz Sicilia, Carlos González
    Alimentary Pharmacology & Therapeutics.2020; 52(6): 1017.     CrossRef
  • Objectively assessed disease activity and drug persistence during ustekinumab treatment in a nationwide real-world Crohn’s disease cohort
    Clas-Göran af Björkesten, Tuire Ilus, Taru Hallinen, Erkki Soini, Anja Eberl, Kalle Hakala, Mikko Heikura, Airi Jussila, Ritva Koskela, Inka Koskinen, Veikko Moilanen, Christian Nielsen, Urpo Nieminen, Heikki Nuutinen, Markku Heikkinen, Ulla-Maija Suhonen
    European Journal of Gastroenterology & Hepatology.2020; 32(12): 1507.     CrossRef
  • Ustekinumab in Crohn's disease: Effectiveness and safety in clinical practice
    Cristina Saldaña Dueñas, María Rullán Iriarte, Alfonso Elosua González, Cristina Rodríguez Gutiérrez, Saioa Rubio Iturria, Óscar Nantes Castillejo
    Gastroenterología y Hepatología (English Edition).2020; 43(9): 497.     CrossRef
  • Editorial: real‐world short‐term effectiveness of ustekinumab in 305 patients with Crohn’s disease—results from the ENEIDA registry. Authors' reply
    Marisa Iborra, Belén Beltrán, Pilar Nos
    Alimentary Pharmacology & Therapeutics.2019; 50(5): 600.     CrossRef
  • 8,199 View
  • 274 Download
  • 15 Web of Science
  • 19 Crossref
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Inflammatory bowel diseases
Iranian Registry of Crohn’s and Colitis: study profile of first nation-wide inflammatory bowel disease registry in Middle East
Masoud M Malekzadeh, Alireza Sima, Sudabeh Alatab, Anahita Sadeghi, Nasser Ebrahimi Daryani, Payman Adibi, Iradj Maleki, Hassan Vossoughinia, Hafez Fakheri, Abbas Yazdanbod, Seyed Alireza Taghavi, Rahim Aghazadeh, Mohammad Hassan Somi, Kazem Zendedel, Homayoon Vahedi, Reza Malekzadeh
Intest Res 2019;17(3):330-339.   Published online April 24, 2019
DOI: https://doi.org/10.5217/ir.2018.00157
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background/Aims
A recent study revealed increasing incidence and prevalence of inflammatory bowel disease (IBD) in Iran. The Iranian Registry of Crohn’s and Colitis (IRCC) was designed recently to answer the needs. We reported the design, methods of data collection, and aims of IRCC in this paper.
Methods
IRCC is a multicenter prospective registry, which is established with collaboration of more than 100 gastroenterologists from different provinces of Iran. Minimum data set for IRCC was defined according to an international consensus on standard set of outcomes for IBD. A pilot feasibility study was performed on 553 IBD patients with a web-based questionnaire. The reliability of questionnaire evaluated by Cronbach’s α.
Results
All sections of questionnaire had Cronbach’s α of more than 0.6. In pilot study, 312 of participants (56.4%) were male and mean age was 38 years (standard deviation=12.8) and 378 patients (68.35%) had ulcerative colitis, 303 subjects (54,7%) had college education and 358 patients (64.74%) were of Fars ethnicity. We found that 68 (12.3%), 44 (7.9%), 13 (2.3%) of participants were smokers, hookah and opium users, respectively. History of appendectomy was reported in 58 of patients (10.48%). The most common medication was 5-aminosalicylate (94.39%).
Conclusions
To the best of our knowledge, IRCC is the first national IBD registry in the Middle East and could become a reliable infrastructure for national and international research on IBD. IRCC will improve the quality of care of IBD patients and provide national information for policy makers to better plan for controlling IBD in Iran.

Citations

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  • Genomic testing identifies monogenic causes in patients with very early-onset inflammatory bowel disease: a multicenter survey in an Iranian cohort
    Golnaz Eslamian, Mahnaz Jamee, Tooba Momen, Pejman Rohani, Sarehossadat Ebrahimi, Mehrnaz Mesdaghi, Soodeh Ghadimi, Mahboubeh Mansouri, Seyed Alireza Mahdaviani, Mahnaz Sadeghi-shabestari, Morteza Fallahpour, Bibi Shahin Shamsian, Narges Eslami, Samin Sha
    Clinical and Experimental Immunology.2024; 217(1): 1.     CrossRef
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    Shaghayegh Khanmohammadi, Ali Sheidaei, Sudabeh Alatab, Ozra Tabatabaei-Malazy, Homayoon Vahedi, Fariborz Mansour-Ghanaei, Hafez Fakheri, Farshad Sheikhesmaeili, Anahita Sadeghi, Ali Reza Sima, Amir Anushiravan, Abbas Yazdanbod, Seyed Hamid Moosavy, Iradj
    PLOS ONE.2024; 19(7): e0304792.     CrossRef
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    Leila Mighani, Malihe Eilakinezhad, Seyed-Alireza Esmaeili, Majid Khazaei, Moein Eskandari, Seyedeh Elnaz Nazari, Mojtaba Mousavi Bazaz, Khatereh kharazmi, Elham Moghaddas, Mehdi Zarean
    Scientific Reports.2024;[Epub]     CrossRef
  • The cost of illness analysis of inflammatory bowel disease
    Majid Pakdin, Leila Zarei, Kamran Bagheri Lankarani, Sulmaz Ghahramani
    BMC Gastroenterology.2023;[Epub]     CrossRef
  • Iranian Consensus Guideline for Pharmacotherapy with Biologics and Small Molecules Drugs in Adults with Inflammatory Bowel Diseases
    Niloofar Khoshnam-Rad, Homayoon Vahedi, Anahita Sadeghi, Mansoor Rastegarpanah, Soha Namazi, Amir Anushiravani, Ali Reza Sima, Shabnam Shahrokh, Sudabeh Alatab, Reza Malekzadeh
    Middle East Journal of Digestive Diseases.2023; 15(2): 83.     CrossRef
  • Clinical Phenotype and Disease Course of Inflammatory Bowel Disease: A Comparison Between Sporadic and Familial Cases
    Bahar Saberzadeh-Ardestani, Amir Anushiravani, Fariborz Mansour-Ghanaei, Hafez Fakheri, Homayoon Vahedi, Farshad Sheikhesmaeili, Abbas Yazdanbod, Seyed Hamid Moosavy, Hasan Vosoghinia, Iradj Maleki, Siavosh Nasseri-Moghaddam, Bardia Khosravi, Masoud Malek
    Inflammatory Bowel Diseases.2022; 28(7): 1004.     CrossRef
  • Susceptibility of Patients with Inflammatory Bowel Disease to COVID-19 Compared with Their Households
    Amir Anushiravani, Bahar Saberzadeh-Ardestani, Homayoon Vahedi, Hafez Fakheri, Fariborz Mansour-Ghanaei, Iraj Maleki, Siavosh Nasseri-Moghaddam, Hasan Vosoghinia, Mohammad Reza Ghadir, Ahmad Hormati, Amir Kasaeian, Amir Reza Radmard, Bardia Khosravi, Maso
    Middle East Journal of Digestive Diseases.2022; 14(2): 182.     CrossRef
  • Risk Factors Affecting 90-day Readmission of Patients with Inflammatory Bowel Disease
    Sulmaz Ghahramani, Zahra Tamartash, Mohammad Sayari, Homayoun Vahedi, Fatemeh Karimian, Sadegh Heydari, Kamran Bagheri Lankarani
    Middle East Journal of Digestive Diseases.2022; 14(1): 34.     CrossRef
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    Su Bee Park, Jin Young Yoon, Jae Myung Cha
    Gut and Liver.2022; 16(5): 676.     CrossRef
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    Sara Momtazmanesh, Mehran Gholami, Neda Pak, Ali Reza Sima, Seyed Ali Montazeri, Shadi Kolahdoozan, Homayoun Vahedi, Amir Reza Radmard
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    Seong Ran Jeon, Jin-Oh Kim, Jeong-Sik Byeon, Dong-Hoon Yang, Bong Min Ko, Hyeon Jeong Goong, Hyun Joo Jang, Soo Jung Park, Eun Ran Kim, Sung Noh Hong, Jong Pil Im, Seong-Eun Kim, Ja Seol Koo, Chang Soo Eun, Dong Kyung Chang
    Gut and Liver.2021; 15(3): 375.     CrossRef
  • Short-term tolerability and effectiveness of methotrexate monotherapy in adult patients with Crohn’s disease: a retrospective study
    Hee Seung Hong, Kyuwon Kim, Kyunghwan Oh, Jae Yong Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park
    Therapeutic Advances in Gastroenterology.2021;[Epub]     CrossRef
  • Treatment of inflammatory bowel diseases: focusing on 5-aminosalicylates and immunomodulators
    You Sun Kim
    Journal of the Korean Medical Association.2021; 64(9): 596.     CrossRef
  • Association of LRRK2 rs11564258 single nucleotide polymorphisms with type and extent of gastrointestinal mycobiome in ulcerative colitis: a case–control study
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    Gut Pathogens.2021;[Epub]     CrossRef
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  • 193 Download
  • 18 Web of Science
  • 16 Crossref
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Reviews
Colorectal neoplasia
Prevalence and risk factors of colorectal cancer in Asia
Martin CS Wong, Hanyue Ding, Jingxuan Wang, Paul SF Chan, Junjie Huang
Intest Res 2019;17(3):317-329.   Published online May 20, 2019
DOI: https://doi.org/10.5217/ir.2019.00021
AbstractAbstract PDFPubReaderePub
Globally, colorectal cancer (CRC) is a substantial public health burden, and it is increasingly affecting populations in Asian countries. The overall prevalence of CRC is reported to be low in Asia when compared with that in Western nations, yet it had the highest number of prevalent cases. This review described the prevalence of CRC in Asia according to the International Agency for Research on Cancer from World Health Organization (WHO) database and summarized its major risk factors. Non-modifiable factors include genetic factors, ethnicity, age, gender, family history and body height; smoking, alcohol drinking, weight, Westernized diet, physical inactivity, chronic diseases and microbiota were involved in environmental factors. These risk factors were separately discussed in this review according to published literature from Asian countries. CRC screening has been playing an important role in reducing its disease burden. Some recommendations on its screening practices have been formulated in guidelines for Asia Pacific countries.

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Close layer
IBD
Stem cell-based therapy for inflammatory bowel disease
Hiromichi Shimizu, Kohei Suzuki, Mamoru Watanabe, Ryuichi Okamoto
Intest Res 2019;17(3):311-316.   Published online July 25, 2019
DOI: https://doi.org/10.5217/ir.2019.00043
AbstractAbstract PDFPubReaderePub
Inflammatory bowel disease (IBD) is an idiopathic, multi-etiological disease characterized by inflammation and mucosal destruction of the gastrointestinal tract. Despite the remarkable advance in immunomodulating therapies, there still remains a certain population of patients who are refractory to conventional as well as biologic therapies and fail to achieve mucosal healing. To improve the prognosis of those patients, at least 2 types of stem cells have been tested for their potential therapeutic use. Transplantation of hematopoietic stem cells or mesenchymal stem cells have been tested in several clinical studies, but their beneficial effect still remains controversial. In this review, we would like to overview the recent clinical challenges of stem cell-based therapies in IBD and also introduce our new therapeutic plan of intestinal stem cell transplantation for IBD, based on our ex vivo intestinal organoid culture technique.

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IBD
Best practices on immunomodulators and biologic agents for ulcerative colitis and Crohn’s disease in Asia
Choon Jin Ooi, Ida Hilmi, Rupa Banerjee, Sai Wei Chuah, Siew Chien Ng, Shu Chen Wei, Govind K Makharia, Pises Pisespongsa, Min Hu Chen, Zhi Hua Ran, Byong Duk Ye, Dong Il Park, Khoon Lin Ling, David Ong, Vineet Ahuja, Khean Lee Goh, Jose Sollano, Wee Chian Lim, Wai Keung Leung, Raja Affendi Raja Ali, Deng Chyang Wu, Evan Ong, Nazri Mustaffa, Julajak Limsrivilai, Tadakazu Hisamatsu, Suk Kyun Yang, Qin Ouyang, Richard Geary, Janaka H De Silva, Rungsun Rerknimitr, Marcellus Simadibrata, Murdani Abdullah, Rupert WL Leong, the Asia Pacific Association of Gastroenterology (APAGE) Working Group on Inflammatory Bowel Disease and Asian Organization for Crohn’s and Colitis
Intest Res 2019;17(3):285-310.   Published online May 31, 2019
DOI: https://doi.org/10.5217/ir.2019.00026
AbstractAbstract PDFPubReaderePub
The Asia-Pacific Working Group on inflammatory bowel disease (IBD) was established in Cebu, Philippines, under the auspices of the Asian Pacific Association of Gastroenterology with the goal of improving IBD care in Asia. This consensus is carried out in collaboration with Asian Organization for Crohn’s and Colitis. With biologic agents and biosimilars becoming more established, it is necessary to conduct a review on existing literature and establish a consensus on when and how to introduce biologic agents and biosimilars in the conjunction with conventional treatments for ulcerative colitis (UC) and Crohn’s disease (CD) in Asia. These statements also address how pharmacogenetics influence the treatments of UC and CD and provide guidance on response monitoring and strategies to restore loss of response. Finally, the review includes statements on how to manage treatment alongside possible hepatitis B and tuberculosis infections, both common in Asia. These statements have been prepared and voted upon by members of IBD workgroup employing the modified Delphi process. These statements do not intend to be all-encompassing and future revisions are likely as new data continue to emerge.

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    Journal of Korean Medical Science.2021;[Epub]     CrossRef
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    Diagnostics.2021; 11(12): 2365.     CrossRef
  • Pharmacogenetics-based personalized treatment in patients with inflammatory bowel disease: A review
    Ji Young Chang, Jae Hee Cheon
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    Soo-Youn Lee
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  • Biologic Use Patterns and Predictors for Non-persistence and Switching of Biologics in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Study
    Yoon Suk Jung, Minkyung Han, Sohee Park, Jae Hee Cheon
    Digestive Diseases and Sciences.2020; 65(5): 1436.     CrossRef
  • Trends in Healthcare Costs for Inflammatory Bowel Disease in South Korea
    Yoon Suk Jung
    Gut and Liver.2020; 14(1): 3.     CrossRef
  • Prevention and management of viral hepatitis in inflammatory bowel disease: a clinical practice guideline by the Korean Association for the Study of Intestinal Diseases
    Soo-Kyung Park, Chang Hwan Choi, Jaeyoung Chun, Heeyoung Lee, Eun Sun Kim, Jae Jun Park, Chan Hyuk Park, Bo-In Lee, Yunho Jung, Dong-Il Park, Do Young Kim, Hana Park, Yoon Tae Jeen
    Intestinal Research.2020; 18(1): 18.     CrossRef
  • Association of Faecal Calprotectin Level and Combined Endoscopic and Radiological Healing in Patients With Crohn’s Disease Receiving Anti-tumour Necrosis Factor Therapy
    Soo Min Noh, Eun Hye Oh, Seong Ho Park, Jung Bok Lee, Jin Yong Kim, Jae Cheol Park, Jeongseok Kim, Nam Seok Ham, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Beyong Duk Ye
    Journal of Crohn's and Colitis.2020; 14(9): 1231.     CrossRef
  • Changes in prevalence and perception of complementary and alternative medicine use in Korean inflammatory bowel disease patients: results of an 8-year follow-up survey
    Sun-Ho Lee, Kiju Chang, Ki Seok Seo, Yun Kyung Cho, Eun Mi Song, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park
    Intestinal Research.2020; 18(2): 192.     CrossRef
  • Indigo Naturalis Alleviates Dextran Sulfate Sodium-Induced Colitis in Rats via Altering Gut Microbiota
    Zhongmei Sun, Junxiang Li, Yi Dai, Wenting Wang, Rui Shi, Zhibin Wang, Panghua Ding, Qiongqiong Lu, Hui Jiang, Wenjing Pei, Xingjie Zhao, Yi Guo, Jiali Liu, Xiang Tan, Tangyou Mao
    Frontiers in Microbiology.2020;[Epub]     CrossRef
  • Similar Clinical Outcomes of Early and Late Anti-TNF Initiation for Ulcerative Colitis: A Nationwide Population-Based Study
    Minkyung Han, Yoon Suk Jung, Jae Hee Cheon, Sohee Park
    Yonsei Medical Journal.2020; 61(5): 382.     CrossRef
  • Long-term prognosis of ulcerative colitis and its temporal changes between 1986 and 2015 in a population-based cohort in the Songpa-Kangdong district of Seoul, Korea
    Jae Myung Cha, Sang Hyoung Park, Kyoung Hoon Rhee, Sung Noh Hong, Young-Ho Kim, Seung In Seo, Kyung Ho Kim, Seung Kyu Jeong, Ji Hyun Lee, Sun Yong Park, Hyunju Park, Joo Sung Kim, Jong Pil Im, Hyuk Yoon, Sung Hoon Kim, Jisun Jang, Jeong Hwan Kim, Seong O
    Gut.2020; 69(8): 1432.     CrossRef
  • Inflammatory Bowel Disease – Non-biological treatment
    Fernando Magro, Gonçalo Cordeiro, Andreia Martins Dias, Maria Manuela Estevinho
    Pharmacological Research.2020; 160: 105075.     CrossRef
  • Use of small bowel capsule endoscopy in clinical practice: how has it performed?
    Seong Ran Jeon
    The Korean Journal of Internal Medicine.2020; 35(4): 854.     CrossRef
  • Impact of early anti-TNF use on clinical outcomes in Crohn’s disease: a nationwide population-based study
    Yoon Suk Jung, Minkyung Han, Sohee Park, Jae Hee Cheon
    The Korean Journal of Internal Medicine.2020; 35(5): 1104.     CrossRef
  • Nanocomposites-based targeted oral drug delivery systems with infliximab in a murine colitis model
    Jung Min Kim, Da Hye Kim, Hyo Jeong Park, Hyun Woo Ma, I Seul Park, Mijeong Son, So Youn Ro, Seokmann Hong, Hyo Kyung Han, Soo Jeong Lim, Seung Won Kim, Jae Hee Cheon
    Journal of Nanobiotechnology.2020;[Epub]     CrossRef
  • Challenges in the diagnosis and management of inflammatory bowel disease in resource-limited settings in Asia
    Rupa Banerjee, Partha Pal, Joyce Wing Yan Mak, Siew C Ng
    The Lancet Gastroenterology & Hepatology.2020; 5(12): 1076.     CrossRef
  • Optimising management strategies of inflammatory bowel disease in resource-limited settings in Asia
    Siew C Ng, Joyce Wing Yan Mak, Partha Pal, Rupa Banerjee
    The Lancet Gastroenterology & Hepatology.2020; 5(12): 1089.     CrossRef
  • NUDT15 C415T variant compared with TPMT genotyping in predicting azathioprine‐induced leucopenia: prospective analysis of 1014 inflammatory bowel disease patients in India
    Rupa Banerjee, Vishnubhotla Venkata Ravikanth, Partha Pal, Govardhan Bale, Urmila Steffie Avanthi, Idan Goren, B. Ganesh Girish, Sasikala Mitnala, D. Nageshwar Reddy
    Alimentary Pharmacology & Therapeutics.2020; 52(11-12): 1683.     CrossRef
  • 29,417 View
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Editorial
IBD
Subcutaneous integrin inhibitors may provide more treatment options for patients with moderate-to-severe ulcerative colitis
Hyuk Yoon
Intest Res 2019;17(3):283-284.   Published online July 25, 2019
DOI: https://doi.org/10.5217/ir.2019.00070
PDFPubReaderePub
  • 5,007 View
  • 106 Download
  • 1 Web of Science
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Images of the Issue
Endoscopy
Rectal polypoid lesion with a nodular surface
Jae Hyun Kim
Intest Res 2019;17(2):281-282.   Published online February 7, 2019
DOI: https://doi.org/10.5217/ir.2018.00172
PDFPubReaderePub
  • 5,842 View
  • 88 Download
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Brief Communication
Colorectal neoplasia
Lack of reliability of self-reports by patients with advanced colorectal polyps
Benjamin Fiedler, Lawrence Fiedler, Michael A. DeDonno, Kosi Anago, Leonie de la Cruz, George R. Luck, Charles H. Hennekens
Intest Res 2019;17(2):278-280.   Published online December 14, 2018
DOI: https://doi.org/10.5217/ir.2018.00144
PDFPubReaderePub

Citations

Citations to this article as recorded by  
  • Underutilization of Aspirin in Patients With Advanced Colorectal Polyps
    Benjamin Fiedler, Lawrence Fiedler, Michael DeDonno, Kosi Anago, Leonie de la Cruz, George R. Luck, Charles H. Hennekens
    The American Journal of Medicine.2019;[Epub]     CrossRef
  • 5,631 View
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  • 1 Web of Science
  • 1 Crossref
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Case Report
IBD
Remission of diffuse ulcerative duodenitis in a patient with ulcerative colitis after infliximab therapy: a case study and review of the literature
Yong-Sung Choi, Jong Kyu Kim, Wan Jung Kim, Mi-Jung Kim
Intest Res 2019;17(2):273-277.   Published online February 12, 2019
DOI: https://doi.org/10.5217/ir.2018.00122
AbstractAbstract PDFPubReaderePub
Although ulcerative colitis (UC) is confined to colonic and rectal mucosa in a continuous fashion, recent studies have also demonstrated the involvement of upper gastrointestinal tract as diagnostic endoscopy becomes more available and technically advanced. The pathogenesis of UC is not well established yet. It might be associated with an inappropriate response of host mucosal immune system to gut microflora. Although continuous and symmetric distribution of mucosal inflammation from rectum to colon is a typical pattern of UC, clinical feature and course of atypically distributed lesions in UC might also help us understand the pathogenesis of UC. Herein, we report a case of duodenal involvement of UC which successfully remitted after infliximab therapy. Endoscopic and pathologic findings before and after administration of anti-tumor necrosis factor suggest that the pathogenesis of upper gastrointestinal involvement of UC may be similar to that of colon involvement.

Citations

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  • Gastroduodenitis Associated with Active Ulcerative Colitis Treated with Infliximab: Different Clinical Course in the Colon and Gastroduodenal Lesions
    Tomoyuki Hayashi, Takeshi Terashima, Masaki Nishitani, Noriaki Orita, Masaki Miyazawa, Akihiro Seki, Hidetoshi Nakagawa, Kouki Nio, Noriho Iida, Shinya Yamada, Hajime Takatori, Tetsuro Shimakami, Taro Yamashita
    Internal Medicine.2024; 63(7): 929.     CrossRef
  • Severe Disease Activity May Predispose Patients to Post-colectomy Duodenitis Associated with Ulcerative Colitis
    Akira Sonoda, Naoki Yoshimura, Minako Sako, Soh Okano, Satoshi Saito, Masakazu Takazoe, Satomi Furukawa, Kinya Okamoto, Tetsuo Yamana, Hisateru Tachimori, Masayuki Fukata
    Internal Medicine.2024; 63(10): 1337.     CrossRef
  • Concurrent occurrence of ulcerative duodenitis and ulcerative colitis displaying unique responses to golimumab and ustekinumab
    Sho Masaki, Hajime Honjo, Masayuki Kurimoto, Natsuki Okai, Yasuo Otsuka, Yasuhiro Masuta, Ken Kamata, Kosuke Minaga, Masatoshi Kudo, Tomohiro Watanabe
    Clinical Journal of Gastroenterology.2024; 17(5): 854.     CrossRef
  • Upper Gastrointestinal Tract Involvement in Inflammatory Bowel Diseases: Histologic Clues and Pitfalls
    Bence Kővári, Rish K. Pai
    Advances in Anatomic Pathology.2022; 29(1): 2.     CrossRef
  • Mucosal lesions of the upper gastrointestinal tract in patients with ulcerative colitis: A review
    Yan Sun, Zhe Zhang, Chang-Qing Zheng, Li-Xuan Sang
    World Journal of Gastroenterology.2021; 27(22): 2963.     CrossRef
  • Clinical characteristics and prognosis of patients with ulcerative colitis that shows rectal sparing at initial diagnosis
    Yong-Sung Choi, Jong-Kyu Kim, Wan-Jung Kim
    World Journal of Gastrointestinal Endoscopy.2021; 13(9): 407.     CrossRef
  • Upper Gastrointestinal Manifestations of Inflammatory Bowel Disease
    Noam Harpaz, Alexandros D. Polydorides
    Surgical Pathology Clinics.2020; 13(3): 413.     CrossRef
  • Two Cases of Ulcerative Colitis-like Gastroduodenitis after Total Proctocolectomy for Intractable Ulcerative Colitis
    Takahiro SHIMOYAMA, Takayuki YAMAMOTO, Yasuhiro INOUE, Satoru UMEGAE
    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2019; 80(5): 904.     CrossRef
  • 11,927 View
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Original Articles
Endoscopy
Efficacy and safety of cold forceps polypectomy utilizing the jumbo cup: a prospective study
Hiroshi Hasegawa, Shigeki Bamba, Kenichiro Takahashi, Masaki Murata, Taketo Otsuka, Hiroshi Matsumoto, Takehide Fujimoto, Rie Osak, Hirotsugu Imaeda, Atsushi Nishida, Hiromitsu Ban, Ayano Sonoda, Osamu Inatomi, Masaya Sasaki, Mitsushige Sugimoto, Akira Andoh
Intest Res 2019;17(2):265-272.   Published online November 28, 2018
DOI: https://doi.org/10.5217/ir.2018.00103
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background/Aims
There are few prospective studies on cold forceps polypectomy (CFP) using jumbo cup forceps. Therefore, we examined patients with diminutive polyps (5 mm or smaller) treated with CFP using jumbo cup forceps to achieve an adenoma-free colon and also assessed the safety of the procedure and the recurrence rate of missed or residual polyp after CFP by performing follow-up colonoscopy 1 year later.
Methods
We included patients with up to 5 adenomas removed at initial colonoscopy and analyzed data from a total of 361 patients with 573 adenomas. One-year follow-up colonoscopy was performed in 165 patients, at which 251 lesions were confirmed.
Results
The one-bite resection rate with CFP was highest for lesions 3 mm or smaller and decreased significantly with increasing lesion size. Post-procedural hemorrhage was observed in 1 of 573 lesions (0.17%). No perforation was noted. The definite recurrence rate was 0.8% (2/251 lesions). The probable recurrence rate, which was defined as recurrence in the same colorectal segment, was 17%. Adenoma-free colon was achieved in 55% of patients at initial resection. Multivariate analysis revealed that achievement of an adenoma-free colon was significantly associated with number of adenomas and years of endoscopic experience.
Conclusions
CFP using jumbo biopsy forceps was safe and showed a high one-bite resection rate for diminutive lesions of 3 mm or smaller. The low definite recurrence rate confirms the reliability of CFP using jumbo biopsy forceps. Number of adenomas and years of endoscopic experience were key factors in achieving an adenoma-free colon.

Citations

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  • Polypectomy for Diminutive and Small Colorectal Polyps
    Melissa Zarandi-Nowroozi, Roupen Djinbachian, Daniel von Renteln
    Gastrointestinal Endoscopy Clinics of North America.2022; 32(2): 241.     CrossRef
  • Cold Snare Resection of Colorectal Polyps: Updates and Recent Developments
    Roupen Djinbachian, Daniel von Renteln
    Current Treatment Options in Gastroenterology.2022; 20(3): 221.     CrossRef
  • Prospective multicenter study of the efficacy and safety of cold forceps polypectomy for ≤ 6-mm non-ampullary duodenal low-grade adenomas
    Hiromitsu Kanzaki, Joichiro Horii, Ryuta Takenaka, Hiroyuki Nakagawa, Kazuhiro Matsueda, Takao Tsuzuki, Masahide Kita, Yasushi Yamasaki, Takehiro Tanaka, Masaya Iwamuro, Seiji Kawano, Yoshiro Kawahara, Jun Tomoda, Hiroyuki Okada
    Endoscopy International Open.2022; 10(06): E712.     CrossRef
  • Endoscopic resection of local recurrences of diminutive polyps by cold forceps polypectomy
    Toshio Kuwai, Takuya Yamada, Tatsuya Toyokawa, Tomohiro Kudo, Naoki Esaka, Hajime Ohta, Haruhiro Yamashita, Yasuo Hosoda, Noriko Watanabe, Naohiko Harada
    Scandinavian Journal of Gastroenterology.2021; 56(3): 363.     CrossRef
  • How to Approach Small Polyps in Colon: Tips and Tricks
    Sultan Mahmood, Enrik John Aguila, Asad ur Rahman, Asim Shuja, Steven Bollipo
    Techniques and Innovations in Gastrointestinal Endoscopy.2021; 23(4): 328.     CrossRef
  • Risk factors for incomplete polyp resection during colonoscopy
    Weifeng Lao, Pankaj Prasoon, Gaoyang Cao, Lian Tat Tan, Sheng Dai, Giridhar Hanumappa Devadasar, Xuefeng Huang
    Laparoscopic, Endoscopic and Robotic Surgery.2021;[Epub]     CrossRef
  • Rates of Incomplete Resection of 1- to 20-mm Colorectal Polyps: A Systematic Review and Meta-Analysis
    Roupen Djinbachian, Ryma Iratni, Madeleine Durand, Paola Marques, Daniel von Renteln
    Gastroenterology.2020; 159(3): 904.     CrossRef
  • Child-Pugh B or C Cirrhosis Increases the Risk for Bleeding Following Colonoscopic Polypectomy
    Hosim Soh, Jaeyoung Chun, Seung Wook Hong, Seona Park, Yun Bin Lee, Hyun Jung Lee, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Jong Pil Im, Yoon Jun Kim, Joo Sung Kim, Jung-Hwan Yoon
    Gut and Liver.2020; 14(6): 755.     CrossRef
  • 10,180 View
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  • 7 Web of Science
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Colorectal neoplasia
Development and validation of a scoring system for advanced colorectal neoplasm in young Korean subjects less than age 50 years
Ji Yeon Kim, Sungkyoung Choi, Taesung Park, Seul Ki Kim, Yoon Suk Jung, Jung Ho Park, Hong Joo Kim, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Kyu Yong Choi, Dong Il Park
Intest Res 2019;17(2):253-264.   Published online November 20, 2018
DOI: https://doi.org/10.5217/ir.2018.00062
AbstractAbstract PDFPubReaderePub
Background/Aims
Colorectal cancer incidence among patients aged ≤50 years is increasing. This study aimed to develop and validate an advanced colorectal neoplasm (ACRN) screening model for young adults aged <50 years in Korea.
Methods
This retrospective cross-sectional study included 59,575 consecutive asymptomatic Koreans who underwent screening colonoscopy between 2003 and 2012 at a single comprehensive health care center. Young Adult Colorectal Screening (YCS) score was developed as an optimized risk stratification model for ACRN using multivariate analysis and was internally validated. The predictive power and diagnostic performance of YCS score was compared with those of Asia-Pacific Colorectal Screening (APCS) and Korean Colorectal Screening (KCS) scores.
Results
41,702 and 17,873 subjects were randomly allocated into the derivation and validation cohorts, respectively, by examination year. ACRN prevalence was 0.9% in both cohorts. YCS score comprised sex, age, alcohol, smoking, obesity, glucose metabolism abnormality, and family history of CRC, with score ranges of 0 to 10. In the validation cohort, ACRN prevalence was 0.6% in the low-risk tier (score, 0–4), 1.5% in the moderate-risk tier (score, 5–7), and 3.4% in the high-risk tier (score, 8–10). ACRN risk increased 2.5-fold (95%CI, 1.8–3.4) in the moderate-risk tier and 5.8-fold (95%CI, 3.4–9.8) in the high-risk tier compared with the low-risk tier. YCS score identified better balanced accuracy (53.9%) than APCS (51.5%) and KCS (50.7%) scores and had relatively good discriminative power (area under the curve=0.660).
Conclusions
YCS score based on clinical and laboratory risk factors was clinically effective and beneficial for predicting ACRN risk and targeting screening colonoscopy in adults aged <50 years.

Citations

Citations to this article as recorded by  
  • Performance of the Asia–Pacific Colorectal Screening score in stratifying the risk of advanced colorectal neoplasia: A meta‐analysis and systematic review
    Mai Ngoc Luu, Nhi Ai Trinh, Truc Le Thanh Tran, Thinh Phuong Dang, Toru Hiyama, Duc Trong Quach
    Journal of Gastroenterology and Hepatology.2024; 39(6): 1000.     CrossRef
  • Response to commentaries on “Performance of the Asia‐Pacific colorectal screening score in stratifying the risk of advanced colorectal neoplasia: A meta‐analysis and systematic review”
    MN Luu, DT Quach
    Journal of Gastroenterology and Hepatology.2024;[Epub]     CrossRef
  • Family History of Colorectal Cancer and the Risk of Colorectal Neoplasia: A Systematic Review and Meta-Analysis
    Kai Gao, Huyi Jin, Yi Yang, Jiayu Li, Yuanliang He, Ruiyao Zhou, Wanting Zhang, Xiangrong Gao, Zongming Yang, Mengling Tang, Jianbing Wang, Ding Ye, Kun Chen, Mingjuan Jin
    American Journal of Gastroenterology.2024;[Epub]     CrossRef
  • Updated epidemiology of gastrointestinal cancers in East Asia
    Junjie Huang, Don Eliseo Lucero-Prisno, Lin Zhang, Wanghong Xu, Sunny H. Wong, Siew C. Ng, Martin C. S. Wong
    Nature Reviews Gastroenterology & Hepatology.2023; 20(5): 271.     CrossRef
  • From Algorithms to Clinical Utility: A Systematic Review of Individualized Risk Prediction Models for Colorectal Cancer
    Deborah Jael Herrera, Wessel van de Veerdonk, Daiane Maria Seibert, Moges Muluneh Boke, Claudia Gutiérrez-Ortiz, Nigus Bililign Yimer, Karen Feyen, Allegra Ferrari, Guido Van Hal
    Gastrointestinal Disorders.2023; 5(4): 549.     CrossRef
  • Emergence of a New Optical Marker for Colorectal Neoplasms: To What Extent Should We Accept It?
    Han Hee Lee
    Clinical Endoscopy.2022; 55(2): 315.     CrossRef
  • Is early-onset cancer an emerging global epidemic? Current evidence and future implications
    Tomotaka Ugai, Naoko Sasamoto, Hwa-Young Lee, Mariko Ando, Mingyang Song, Rulla M. Tamimi, Ichiro Kawachi, Peter T. Campbell, Edward L. Giovannucci, Elisabete Weiderpass, Timothy R. Rebbeck, Shuji Ogino
    Nature Reviews Clinical Oncology.2022; 19(10): 656.     CrossRef
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    Yoon Suk Jung
    Precision and Future Medicine.2021; 5(2): 69.     CrossRef
  • How to Choose the Optimal Bowel Preparation Regimen for Colonoscopy
    Ji Eun Na, Eun Ran Kim
    The Ewha Medical Journal.2021; 44(4): 122.     CrossRef
  • The Role of Diet and Lifestyle in Early-Onset Colorectal Cancer: A Systematic Review
    Marta Puzzono, Alessandro Mannucci, Simone Grannò, Raffaella Alessia Zuppardo, Andrea Galli, Silvio Danese, Giulia Martina Cavestro
    Cancers.2021; 13(23): 5933.     CrossRef
  • Association between waist circumference and risk of colorectal neoplasia in normal‐weight adults
    Yoon Suk Jung, Nam Hee Kim, Hyo‐Joon Yang, Soo‐Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn
    Journal of Gastroenterology and Hepatology.2020; 35(1): 43.     CrossRef
  • Risk prediction rule for advanced neoplasia on screening colonoscopy for average-risk individuals
    Ala I Sharara, Ali El Mokahal, Ali H Harb, Natalia Khalaf, Fayez S Sarkis, Mustapha M El-Halabi, Nabil M Mansour, Ahmad Malli, Robert Habib
    World Journal of Gastroenterology.2020; 26(37): 5705.     CrossRef
  • Risk Factors Associated With Young-Onset Colorectal Adenomas and Cancer: A Systematic Review and Meta-Analysis of Observational Research
    Genevieve Breau, Ursula Ellis
    Cancer Control.2020;[Epub]     CrossRef
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    Martin CS Wong, Hanyue Ding, Jingxuan Wang, Paul SF Chan, Junjie Huang
    Intestinal Research.2019; 17(3): 317.     CrossRef
  • 8,874 View
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IBD
The impact of corticosteroid use on inpatients with inflammatory bowel disease and positive polymerase chain reaction for Clostridium difficile
Huei-Wen Lim, Isaiah P. Schuster, Ramona Rajapakse, Farah Monzur, Sundas Khan, Keith Sultan
Intest Res 2019;17(2):244-252.   Published online February 12, 2019
DOI: https://doi.org/10.5217/ir.2018.00101
AbstractAbstract PDFPubReaderePub
Background/Aims
Optimal management of inflammatory bowel disease (IBD) with concomitant Clostridium difficile infection (CDI) is controversial, especially when CDI diagnosis is made by polymerase chain reaction (PCR) testing, which may reflect colonization without infection.
Methods
We performed a multicenter review of all inpatients with IBD and PCR diagnosed CDI. Outcomes included length of stay, 30- and 90-day readmission, colectomy during admission and within 3 months, intensive care unit (ICU) admission, CDI relapse and death for patients who received corticosteroid (CS) after CDI diagnosis versus those that did not. Propensity-adjusted regression analysis of outcomes based on CS usage was performed.
Results
We identified 177 IBD patients with CDI, 112 ulcerative colitis and 65 Crohn’s disease. For IBD overall, CS after CDI diagnosis was associated with prolonged hospitalization (5.5 days: 95% confidence interval [CI], 1.5–9.6 days; P=0.008), higher colectomy rate within 3 months (odds ratio [OR], 5.5; 95% CI, 1.1–28.2; P=0.042) and more frequent ICU admissions (OR, 7.8; 95% CI, 1.5–41.6; P=0.017) versus no CS. CS use post-CDI diagnosis in UC patients was associated with prolonged hospitalization (6.2 days: 95% CI, 0.4– 12.0 days; P=0.036) and more frequent ICU admissions (OR, 7.4; 95% CI, 1.1–48.7; P=0.036).
Conclusions
CS use among IBD inpatients with CDI diagnosed by PCR is associated with poorer outcomes and would seem to reinforce the importance of C. difficile toxin assay to help distinguish colonization from infection. This adverse effect appears more prominent among those with UC.

Citations

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  • Clostridioides difficile infection in inflammatory bowel disease: a clinical review
    Mengjun Tang, Chunhua Wang, Ying Xia, Jian Tang, Jiao Wang, Liang Shen
    Expert Review of Anti-infective Therapy.2024; 22(5): 297.     CrossRef
  • The Current Knowledge on Clostridioides difficile Infection in Patients with Inflammatory Bowel Diseases
    Alina Boeriu, Adina Roman, Crina Fofiu, Daniela Dobru
    Pathogens.2022; 11(7): 819.     CrossRef
  • Korean Association for the Study of Intestinal Diseases guidance for clinical practice of adult inflammatory bowel disease during the coronavirus disease 2019 pandemic: expert consensus statements
    Yong Eun Park, Yoo Jin Lee, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seong-Eun Kim, Seung-Jae Myung
    Intestinal Research.2022; 20(4): 431.     CrossRef
  • KASID Guidance for Clinical Practice Management of Adult Inflammatory Bowel Disease during the COVID-19 Pandemic: Expert Consensus Statement
    Yong Eun Park, Yoo Jin Lee, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seong-Eun Kim, Seung-Jae Myung
    The Korean Journal of Gastroenterology.2021; 78(2): 105.     CrossRef
  • 9,157 View
  • 171 Download
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IBD
Influence of anti-tumor necrosis factor-alpha therapy to pregnant inflammatory bowel disease women and their children’s immunity
Ko Eun Lee, Sung-Ae Jung, Sang Hyoung Park, Chang Mo Moon, So Yeon Shim, Eun Soo Kim, Su Jin Cho, Seong-Eun Kim, Kwang Bum Cho, Suk-Kyun Yang
Intest Res 2019;17(2):237-243.   Published online February 8, 2019
DOI: https://doi.org/10.5217/ir.2018.00071
AbstractAbstract PDFPubReaderePub
Background/Aims
The onset of inflammatory bowel disease (IBD) usually occurs at young age, and therefore, women IBD patients experience pregnancy during their disease progression. Recently, the use of anti-tumor necrosis factor-α (anti-TNF-α) has been rapidly increasing. The aim of this study was to evaluate pregnancy related outcomes in women with IBD who were treated with anti-TNF-α during pregnancy and immunity of their children.
Methods
Korean women with IBD who had been treated with anti-TNF-α during pregnancy had been enrolled. Medical records were reviewed and a survey was performed for each patient. For the patients who agreed on additional examination for their children, children’s growth, medical history and antibody to hepatitis B surface antigen (anti-HBs) titer were checked.
Results
All 18 patients had been diagnosed with Crohn’s disease. There was not any case of preterm delivery, low birth-weight infant, congenital anomaly, nor stillbirth. All 12 children had followed the regular vaccination schedule for hepatitis B and 4 of them showed negative results for anti-HBs. After the 1 booster vaccination, all children demonstrated seroconversion. Regarding live vaccines, 4 children had bacillus Calmette-Guerin and 4 had rotavirus vaccine before 6 months, without any specific side effects.
Conclusions
This was the first study of immunity of the children born from IBD women who had been treated with anti-TNF-α medication during their pregnancy. IBD women had comparable pregnancy outcomes with the general women population, suggesting that the disease activity rather than the administered medication would be more important in healthy pregnancy. Considering the history of vaccination and anti-HBs titers, immunity seems to be intact in the children.

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    Journal of Crohn's and Colitis.2024; 18(Supplement): ii16.     CrossRef
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    Anne R. Bass, Eliza Chakravarty, Elie A. Akl, Clifton O. Bingham, Leonard Calabrese, Laura C. Cappelli, Sindhu R. Johnson, Lisa F. Imundo, Kevin L. Winthrop, Reuben J. Arasaratnam, Lindsey R. Baden, Roberta Berard, S. Louis Bridges, Jonathan T. L. Cheah,
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IBD
Abdominal ultrasonography with color Doppler analysis in the assessment of ileal Crohn’s disease: comparison with magnetic resonance enterography
Antonio Carlos da Silva Moraes, Glycia de Freitas Moraes, Antonio Luis Eiras de Araújo, Ronir Raggio Luiz, Celeste Elia, Antonio Jose Carneiro, Heitor Siffert Pereira de Souza
Intest Res 2019;17(2):227-236.   Published online April 10, 2019
DOI: https://doi.org/10.5217/ir.2018.00124
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background/Aims
Consistently defining disease activity remains a critical challenge in the follow-up of patients with Crohn’s disease (CD). We investigated the potential applicability of abdominal ultrasonography with color Doppler (USCD) analysis for the detection of morphological alterations and inflammatory activity in CD.
Methods
Forty-three patients with CD ileitis/ileocolitis were evaluated using USCD analysis with measurements obtained on the terminal ileum and right colon. Sonographic parameters included wall thickening, stricture, hyperemia, presence of intra-abdominal mass, and fistulas. Patients were evaluated for the clinical activity (Harvey-Bradshaw Index [HBI]), fecal calprotectin (FC) and C-reactive protein (CRP). The USCD performance was assessed using magnetic resonance enterography (MRE) as a criterion standard.
Results
Most measurements obtained with USCD matched the data generated with MRE; however, the agreement improved in clinically active patients where sensitivity, positive predictive value, and accuracy were >80%, considering wall thickening and hyperemia. Complications such as intestinal wall thickening, stricture formation, and hyperemia, were detected in the USCD analysis with moderate agreement with MRE. The best agreement with the USCD analysis was obtained in regard to FC, where the sensitivity, positive predictive value, and accuracy were >70%. The overall performance of USCD was superior to that of HBI, FC and CRP levels, particularly when considering thickening, stricture, and hyperemia parameters.
Conclusions
USCD represents a practical noninvasive and low-cost tool for evaluating patients with ileal or ileocolonic disease, particularly in clinically active CD. Therefore, USCD might become a useful asset in the follow-up of patients with CD.

Citations

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  • Diagnostic Accuracy of Intestinal Ultrasound in the Detection of Intra-Abdominal Complications in Crohn’s Disease: A Systematic Review and Meta-Analysis
    Maarten J Pruijt, Floris A E de Voogd, Nahid S M Montazeri, Faridi S van Etten-Jamaludin, Geert R D’Haens, Krisztina B Gecse
    Journal of Crohn's and Colitis.2024; 18(6): 958.     CrossRef
  • Comparative study between ultrasound and MR enterography in evaluation of Crohn’s disease
    Nada Sayed Mahdy, Sahar Mohammed El-Gaafary, Khaled Hamdy Abdel Mageed, Khaled A. Ali Shehata, Maha Ahmed Sayed AbdelKarim, Essam Mohamed Abdulhafiz
    Egyptian Journal of Radiology and Nuclear Medicine.2024;[Epub]     CrossRef
  • Could ultrasound alone substitute MR imaging in evaluation of Crohn’s disease complications?
    Hany El-Assaly, Asmaa Abdel Baky Mohamed, Hesham Adel Abdel Fattah Mustafa
    Egyptian Journal of Radiology and Nuclear Medicine.2024;[Epub]     CrossRef
  • Radiology plus ileocolonoscopy versus radiology alone in Crohn’s disease: prognosis prediction and mutual agreement
    Hye Kyung Hyun, Jongwook Yu, Eun Ae Kang, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
    The Korean Journal of Internal Medicine.2022; 37(3): 567.     CrossRef
  • Comparison of Diagnostic Performance of Ultrasonography and Magnetic Resonance Enterography in the Assessment of Active Bowel Lesions in Patients with Crohn’s Disease: A Systematic Review and Meta-Analysis
    Da In Lee, Myung-Won You, So Hyun Park, Mirinae Seo, Seong Jin Park
    Diagnostics.2022; 12(8): 2008.     CrossRef
  • Fistulizing Crohn's disease
    Amy L. Lightner, Jean H. Ashburn, Mantaj S. Brar, Michele Carvello, Pramodh Chandrasinghe, Anthony de Buck van Overstraeten, Phillip R. Fleshner, Gaetano Gallo, Paulo Gustavo Kotze, Stefan D. Holubar, Lillian M. Reza, Antonino Spinelli, Scott A. Strong, P
    Current Problems in Surgery.2020; 57(11): 100808.     CrossRef
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IBD
Individualized treatment based on CYP3A5 single-nucleotide polymorphisms with tacrolimus in ulcerative colitis
Shinji Okabayashi, Taku Kobayashi, Eiko Saito, Takahiko Toyonaga, Ryo Ozaki, Shintaro Sagami, Masaru Nakano, Junichi Tanaka, Keiji Yagisawa, Satoshi Kuronuma, Osamu Takeuchi, Toshifumi Hibi
Intest Res 2019;17(2):218-226.   Published online February 7, 2019
DOI: https://doi.org/10.5217/ir.2018.00117
AbstractAbstract PDFPubReaderePub
Background/Aims
The pharmacokinetics of tacrolimus (TAC) is known to be largely influenced by single-nucleotide polymorphisms (SNPs) in CYP3A5. Patients starting TAC require careful dose adjustment, owing to the wide range of optimal dosages, depending on their CYP3A5 expression status. Here, we evaluated whether individualization of TAC dosages based on CYP3A5 SNPs would improve its therapeutic efficacy in ulcerative colitis.
Methods
Twenty-one patients were prospectively treated, with their initial dosage adjusted according to their CYP3A5 status (0.1, 0.15, and 0.2 mg/kg/day for CYP3A5*3/*3, CYP3A5*1/*3, and CYP3A5*1/*1, respectively). Their clinical outcomes were compared with those of patients treated with a fixed dose (0.1 mg/kg/day).
Results
The first blood trough level of CYP3A5 expressors, CYP3A5*1/*3 or CYP3A5*1/*1, and the overall rate in achieving the target blood trough level within a week in the individualized-dose group were significantly higher than those in the fixed-dose group (5.15±2.33 ng/mL vs. 9.63±0.79 ng/mL, P=0.035 and 12.5% vs. 66.7%, P=0.01). The remission rate at 2 weeks in the expressors was as high as that in the nonexpressors, CYP3A5*3/*3, in the individualized-dose group.
Conclusions
Individualized TAC treatment is effective against ulcerative colitis regardless of the CYP3A5 genotype.

Citations

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  • The impact of cytochrome P450 3A genetic polymorphisms on tacrolimus pharmacokinetics in ulcerative colitis patients
    Maizumi Furuse, Shuhei Hosomi, Yu Nishida, Shigehiro Itani, Yuji Nadatani, Shusei Fukunaga, Koji Otani, Fumio Tanaka, Yasuaki Nagami, Koichi Taira, Noriko Kamata, Toshio Watanabe, Kenji Watanabe, Yasuhiro Fujiwara, Erika Cecchin
    PLOS ONE.2021; 16(4): e0250597.     CrossRef
  • Advances in research of tacrolimus for treatment of inflammatory bowel disease
    Jing-Jing Wang, Yi-Hong Fan
    World Chinese Journal of Digestology.2019; 27(13): 842.     CrossRef
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IBD
The effect of vitamin D administration on inflammatory markers in patients with inflammatory bowel disease
Jae Chang Jun, Hyuk Yoon, Yoon Jin Choi, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Joo Sung Kim
Intest Res 2019;17(2):210-217.   Published online November 27, 2018
DOI: https://doi.org/10.5217/ir.2018.00081
AbstractAbstract PDFPubReaderePub
Background/Aims
The exact relationship between vitamin D deficiency and inflammatory bowel disease (IBD) remains unclear. We evaluated the effect of vitamin D3 administration on inflammatory responses and disease severity in patients with IBD.
Methods
We investigated the serum 25-hydroxyvitamin D3 [25-(OH)D] and C-reactive protein (CRP) levels and the partial Mayo score (PMS) in patients with IBD. Vitamin D3 was administered in patients with either vitamin D deficiency or insufficiency and CRP serum vitamin D levels and PMS were re-examined at 6 months of administration.
Results
In 88 patients with Crohn’s disease (CD), a negative correlation was found between serum vitamin D and CRP. In 178 patients with ulcerative colitis (UC), serum vitamin D showed no association with CRP or PMS. Serum vitamin D increased from 11.08±3.63 to 22.69±6.11 ng/mL in 29 patients with CD and from 11.45±4.10 to 24.20±6.61 ng/mL in 41 patients with UC who received vitamin D3 treatment (P<0.001 and P<0.001, respectively). In patients with CD, median ΔCRP was –0.24 in the normalized vitamin D group and –0.11 in the non-normalized group (P=0.308). In patients with UC, median ΔCRP was −0.01 in the normalized vitamin D group and 0.06 in the non-normalized group (P=0.359).
Conclusions
Although a negative correlation was found between serum vitamin D and CRP levels in patients with CD, administration of vitamin D did not improve the CRP level in patients with CD. In patients with UC, serum vitamin D level was unrelated to CRP or PMS.

Citations

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  • The use of vitamin D for patients with inflammatory bowel diseases
    Júlia Novaes Matias, Vinícius Marinho Lima, Giovanna Soares Nutels, Lucas Fornari Laurindo, Sandra Maria Barbalho, Ricardo de Alvares Goulart, Adriano Cressoni Araújo, Rodrigo Buzinaro Suzuki, Elen Landgraf Guiguer
    International Journal for Vitamin and Nutrition Research.2024; 94(1): 54.     CrossRef
  • The effect of vitamin D serum levels on the values of C-reactive protein and fecal calprotectin in patients with ulcerative colitis in clinical remission
    Zarko Krnetic, Tijana Icin, Zeljka Savic, Olgica Latinovic Bosnjak, Vladimir Vracaric, Dimitrije Damjanov, Tatiana Jocic, Radoslav Pejin, Nebojsa Janjic
    Vojnosanitetski pregled.2024; 81(10): 619.     CrossRef
  • Low Vitamin K and Vitamin D Dietary Intake in Patients with Inflammatory Bowel Diseases
    Filippo Vernia, Giorgia Burrelli Scotti, Noemi Sara Bertetti, Giuseppe Donato, Stefano Necozione, Piero Vernia, Nadia Pallotta
    Nutrients.2023; 15(7): 1678.     CrossRef
  • High Risk of Fractures Within 7 Years of Diagnosis in Asian Patients With Inflammatory Bowel Diseases
    Hyung Jin Ahn, Ye-Jee Kim, Ho-Su Lee, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Beom-Jun Kim, Sang Hyoung Park
    Clinical Gastroenterology and Hepatology.2022; 20(5): e1022.     CrossRef
  • High Dose Intramuscular Vitamin D3 Supplementation Impacts the Gut Microbiota of Patients With Clostridioides Difficile Infection
    Sang Hoon Lee, Han-Ki Park, Chang Don Kang, Dae Hee Choi, Sung Chul Park, Jin Myung Park, Seung-Joo Nam, Gi Bong Chae, Kyoung yul Lee, Hyunseok Cho, Sung Joon Lee
    Frontiers in Cellular and Infection Microbiology.2022;[Epub]     CrossRef
  • Influence of Severe Vitamin D Deficiency on the Clinical Course of Inflammatory Bowel Disease
    Nam Seok Ham, Sung Wook Hwang, Eun Hye Oh, Jeongseok Kim, Ho-Su Lee, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang
    Digestive Diseases and Sciences.2021; 66(2): 587.     CrossRef
  • Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
    Laine de Carvalho Guerra Pessoa Mamede, Rafaela Lira Formiga Cavalcanti de Lima, Alexandre Sérgio Silva, João Carlos Lima Rodrigues Pita, Nadjeanny Ingrid Galdino Gomes, Elisama Araújo de Sena, Rhayra Priscila Moraes Nobrega, João Otávio Scarano Alcântara
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 525.     CrossRef
  • The 25(OH)D3, but Not 1,25(OH)2D3 Levels Are Elevated in IBD Patients Regardless of Vitamin D Supplementation and Do Not Associate with Pain Severity or Frequency
    Anna Zielińska, Aleksandra Sobolewska-Włodarczyk, Maria Wiśniewska-Jarosińska, Anita Gąsiorowska, Jakub Fichna, Maciej Sałaga
    Pharmaceuticals.2021; 14(3): 284.     CrossRef
  • The effects of consuming a low-fat yogurt fortified with nano encapsulated vitamin D on serum pro-oxidant-antioxidant balance (PAB) in adults with metabolic syndrome; a randomized control trial
    Niloofar Taghizadeh, Payam Sharifan, Mansoureh Sadat Ekhteraee Toosi, Fatemeh Najar Sedgh Doust, Susan Darroudi, Asma Afshari, Mitra Rezaie, Mohamad Safarian, Hassan Vatanparast, Saeed Eslami, Hamideh Ghazizadeh, Zahra Khorasanchi, Mohammad Bagherniya, Go
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2021; 15(6): 102332.     CrossRef
  • Vitamin D and inflammatory bowel disease: what do we know so far?
    Antonio María Caballero Mateos, Raúl Vicente Olmedo-Martín, Amparo Roa-Colomo, María del Mar Díaz Alcázar, Manuel Valenzuela Barranco
    Revista Española de Enfermedades Digestivas.2020;[Epub]     CrossRef
  • Inflammatory Bowel Disease and Vitamin D
    Ki Bae Kim, Hyoung Woo Kim, Jun Su Lee, Soon Man Yoon
    The Korean Journal of Gastroenterology.2020; 76(6): 275.     CrossRef
  • Vitamin D in Inflammatory Bowel Disease: Biological, Clinical and Therapeutic Aspects
    Raúl Vicente Olmedo-Martín, Inmaculada González-Molero, Gabriel Olveira, Víctor Amo-Trillo, Miguel Jiménez-Pérez
    Current Drug Metabolism.2019; 20(5): 390.     CrossRef
  • Intraluminal Farnesol and Farnesal in the Mealworm's Alimentary Canal: An Unusual Storage Site Uncovering Hidden Eukaryote Ca2+-Homeostasis-Dependent “Golgicrine” Activities
    Arnold De Loof, Liliane Schoofs
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
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IBD
The novel latex agglutination turbidimetric immunoassay system for simultaneous measurements of calprotectin and hemoglobin in feces
Sakiko Hiraoka, Shiho Takashima, Toshihiro Inokuchi, Asuka Nakarai, Masahiro Takahara, Keita Harada, Yasuhiro Seki, Katsunori Watanabe, Jun Kato, Hiroyuki Okada
Intest Res 2019;17(2):202-209.   Published online December 14, 2018
DOI: https://doi.org/10.5217/ir.2018.00086
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background/Aims
Fecal calprotectin (Fcal) as well as the fecal immunochemical test (FIT) are useful biomarkers for detecting activity and mucosal healing in inflammatory bowel diseases. Here, we report the performance of simultaneous measurements of Fcal and FIT for ulcerative colitis (UC) patients using the newly-developed latex agglutination turbidimetric immunoassay (LATIA) system.
Methods
Fcal and hemoglobin were measured by the LATIA system in 152 UC patients who underwent colonoscopy. Fcal was also quantified with a conventional enzyme-linked immunosorbent assay (ELISA). Fecal markers were evaluated in conjunction with the mucosal status of UC, which was assessed via the Mayo endoscopic subscore (MES) classification.
Results
The LATIA system could quantify calprotectin and hemoglobin simultaneously with the same fecal samples within 10 minutes. The values of the Fcal-LATIA closely correlated with those of the Fcal-ELISA (Spearman rank correlation coefficient, r=0.84; P<0.0001). The values of Fcal for each assay and the FIT all significantly correlated with the MESs (Spearman rank correlation coefficient, Fcal-LATIA: r=0.58, Fcal-ELISA: r=0.55, and FIT: r=0.72). The mucosal healing predictability (determined by an MES of 0 alone) of the Fcal-LATIA, Fcal-ELISA, and FIT-LATIA with the cutoffs determined by receiver operating characteristic curve analysis was 0.79, 0.78, and 0.92 for sensitivity, respectively, and 0.78, 0.69, and 0.73 for specificity, respectively.
Conclusions
The performance of the novel Fcal-LATIA was equivalent to that of the conventional Fcal assay. Simultaneous measurements with FITs would promote the clinical relevance of fecal biomarkers in UC.

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  • Systematic scoping review: Use of the faecal immunochemical test residual buffer to enhance colorectal cancer screening
    Timothy McAuliffe, Joseph C. Anderson, Robin J. Larson, Douglas J. Robertson
    Alimentary Pharmacology & Therapeutics.2024; 59(9): 1033.     CrossRef
  • Evaluation of a faecal calprotectin method using the OC-SENSOR PLEDIA
    Shane O’Driscoll, Carolyn Piggott, Sally C. Benton
    Clinical Chemistry and Laboratory Medicine (CCLM).2022; 60(6): 901.     CrossRef
  • International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases
    Ferdinando D'Amico, David T. Rubin, Paulo Gustavo Kotze, Fernando Magro, Britta Siegmund, Taku Kobayashi, Pablo A. Olivera, Peter Bossuyt, Lieven Pouillon, Edouard Louis, Eugeni Domènech, Subrata Ghosh, Silvio Danese, Laurent Peyrin‐Biroulet
    United European Gastroenterology Journal.2021; 9(4): 451.     CrossRef
  • Faecal Calprotectin in Assessment of Mucosal Healing in Adults with Inflammatory Bowel Disease: A Meta-Analysis
    Mariusz A. Bromke, Katarzyna Neubauer, Radosław Kempiński, Małgorzata Krzystek-Korpacka
    Journal of Clinical Medicine.2021; 10(10): 2203.     CrossRef
  • Leucine-rich alpha-2 glycoprotein as a marker of mucosal healing in inflammatory bowel disease
    Eriko Yasutomi, Toshihiro Inokuchi, Sakiko Hiraoka, Kensuke Takei, Shoko Igawa, Shumpei Yamamoto, Masayasu Ohmori, Shohei Oka, Yasushi Yamasaki, Hideaki Kinugasa, Masahiro Takahara, Keita Harada, Masaki Furukawa, Kouichi Itoshima, Ken Okada, Fumio Otsuka,
    Scientific Reports.2021;[Epub]     CrossRef
  • Optimal Cutoff Level of Fecal Calprotectin for Detecting Small Bowel Inflammation in Crohn's Disease
    Eun Soo Kim
    Gut and Liver.2021; 15(5): 637.     CrossRef
  • Fecal calprotectin predicts complete mucosal healing in patients with ulcerative colitis: Systematic review and meta‑analysis
    Zhongsheng Cao, Chenglong Ye, Lunan Li, Xiaoge Geng, Wensheng Pan, Jiyong Jing
    World Academy of Sciences Journal.2021;[Epub]     CrossRef
  • Biochemical Biomarkers of Mucosal Healing for Inflammatory Bowel Disease in Adults
    Małgorzata Krzystek-Korpacka, Radosław Kempiński, Mariusz Bromke, Katarzyna Neubauer
    Diagnostics.2020; 10(6): 367.     CrossRef
  • Prostaglandin E-Major Urinary Metabolite Predicts Relapse in Patients With Ulcerative Colitis in Clinical Remission
    Natsuki Ishida, Kiichi Sugiura, Takahiro Miyazu, Satoshi Tamura, Satoshi Suzuki, Shinya Tani, Mihoko Yamade, Moriya Iwaizumi, Yasushi Hamaya, Satoshi Osawa, Takahisa Furuta, Ken Sugimoto
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    Jun Kato, Takeichi Yoshida, Sakiko Hiraoka
    Expert Review of Clinical Immunology.2019; 15(6): 667.     CrossRef
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Microbiota
Evaluation of commercial probiotic lactic cultures against biofilm formation by Cronobacter sakazakii
Anubhav Jamwal, Kavita Sharma, Rajni Chauhan, Saurabh Bansal, Gunjan Goel
Intest Res 2019;17(2):192-201.   Published online December 3, 2018
DOI: https://doi.org/10.5217/ir.2018.00106
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background/Aims
Cronobacter sakazakii, an emergent pathogen is considered as a major concern to infants and neonates fed on reconstituted powdered infant milk formula. In conjunction with many other factors, biofilm forming capacity adds to its pathogenic potential. In view of the facts that infants are at highest risk to C. sakazakii infections, and emerging antibiotic resistance among pathogens, it is imperative to evaluate probiotic cultures for their efficacy against C. sakazakii. Therefore, pure probiotic strains were isolated from commercial probiotic products and tested for their antimicrobial and anti-biofilm activities against C. sakazakii.
Methods
A total of 6 probiotic strains were tested for their antibiotic susceptibility followed by antimicrobial activity using cell-free supernatant (CFS) against C. sakazakii. The inhibitory activity of CFS against biofilm formation by C. sakazakii was determined using standard crystal violet assay and microscopic observations.
Results
All the probiotic strains were sensitive to ampicillin, tetracycline, vancomycin and carbenicillin whereas most of the strains were resistant to erythromycin and novobiocin. Four of the 6 probiotic derived CFS possessed antimicrobial activity against C. sakazakii at a level of 40 μL. A higher biofilm inhibitory activity (>80%) was observed at initial stages of biofilm formation with weaker activity during longer incubation upto 48 hours (50%–60%).
Conclusions
The study indicated the efficacy of isolated commercial probiotics strains as potential inhibitor of biofilm formation by C. sakazakii and could be further explored for novel bioactive molecules to limit the emerging infections of C. sakazakii.

Citations

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  • 2′-Fucosyllactose as a prebiotic modulates the probiotic responses of Bifidobacterium bifidum
    Jingfang Du, Hong Yang
    Current Research in Food Science.2025; 10: 100975.     CrossRef
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Reviews
IBD
Epithelial-microbial diplomacy: escalating border tensions drive inflammation in inflammatory bowel disease
Stephanie J King, Declan F McCole
Intest Res 2019;17(2):177-191.   Published online March 7, 2019
DOI: https://doi.org/10.5217/ir.2018.00170
AbstractAbstract PDFPubReaderePub
Inflammatory bowel diseases (IBD) are chronic conditions of the gastrointestinal tract-the main site of host-microbial interaction in the body. Development of IBD is not due to a single event but rather is a multifactorial process where a patient’s genetic background, behavioral habits, and environmental exposures contribute to disease pathogenesis. IBD patients exhibit alterations to gut bacterial populations “dysbiosis” due to the inflammatory microenvironment, however whether this alteration of the gut microbiota precedes inflammation has not been confirmed. Emerging evidence has highlighted the important role of gut microbes in developing measured immune responses and modulating other host responses such as metabolism. Much of the work on the gut microbiota has been correlative and there is an increasing need to understand the intimate relationship between host and microbe. In this review, we highlight how commensal and pathogenic bacteria interact with host intestinal epithelial cells and explore how altered microenvironments impact these connections.

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IBD
An overview of the role of exclusive enteral nutrition for complicated Crohn’s disease
Mustafa Adamji, Andrew S Day
Intest Res 2019;17(2):171-176.   Published online December 3, 2018
DOI: https://doi.org/10.5217/ir.2018.00079
AbstractAbstract PDFPubReaderePub
The role and efficacy of exclusive enteral nutrition (EEN) in the treatment of luminal Crohn’s disease (CD) has been well established over the last 2 decades. Consequently, in many centers nutritional therapy is now considered first line therapy in the induction of remission of active CD. However, the use of nutritional therapy in complicated CD has yet to be fully determined. This article aimed to review case reports and clinical trials published in the last decade that have considered and evaluated nutritional therapy in the setting of complicated CD in children and adults. Published literature focusing upon the use of nutritional therapy as part of medical therapy in the management of complicated CD were identified and reviewed. Although there continue to be various interventions utilized for complicated CD, the currently available literature demonstrates that nutritional therapies, especially EEN, have important roles in the management of these complex scenarios. Further assessments, involving large numbers of patients managed with consistent approaches, are required to further substantiate these roles.

Citations

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IBD
Does fecal calprotectin equally and accurately measure disease activity in small bowel and large bowel Crohn’s disease?: a systematic review
Ebby George Simon, Richard Wardle, Aye Aye Thi, Jeanette Eldridge, Sunil Samuel, Gordon William Moran
Intest Res 2019;17(2):160-170.   Published online February 7, 2019
DOI: https://doi.org/10.5217/ir.2018.00114
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Fecal calprotectin (FC) is a highly sensitive disease activity biomarker in inflammatory bowel disease. However, there are conflicting reports on whether the diagnostic accuracy in Crohn’s disease is influenced by disease location. The aim of this study was to undertake a systematic review of the published literature. Relevant databases were searched from inception to November 8, 2016 for cohort and case control studies which had data on FC in patients with isolated small bowel (SB) and large bowel (LB) Crohn’s disease. Reference standards for disease activity were endoscopy, magnetic resonance imaging, computed tomography or a combination of these. The QUADAS-2 research tool was used to assess the risk of bias. There were 5,619 records identified at initial search. The 2,098 duplicates were removed and 3,521 records screened. Sixty-one full text articles were assessed for eligibility and 16 studies were included in the final review with sensitivities and specificities per disease location available from 8 studies. Sensitivities of FC at SB and LB locations ranged from 42.9% to 100% and 66.7% to 100% respectively while corresponding specificities were 50% to 100% and 28.6% to 100% respectively. The sensitivities and specificities of FC to accurately measure disease activity in Crohn’s disease at different disease locations are diverse and no firm conclusion can be made. Better studies need to be undertaken to categorically answer the effect of disease location on the diagnostic accuracy of FC.

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    Pediatrics International.2022;[Epub]     CrossRef
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    José María Paredes, Tomás Ripollés, Ángela Algarra, Rafael Diaz, Nadia Moreno, Patricia Latorre, María Jesús Martínez, Pilar Llopis, Antonio López, Eduardo Moreno-Osset
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  • Fecal Calprotectin for Small Bowel Crohn’s Disease: Is It a Cutoff Issue?
    Cristina Romero-Mascarell, Gloria Fernández-Esparrach, Cristina Rodríguez-De Miguel, Maria Carme Masamunt, Sonia Rodríguez, Jordi Rimola, Miguel Urpí, Gherzon Simon Casanova, Ingrid Ordás, Elena Ricart, Berta Caballol, Agnès Fernández-Clotet, Julià Panés,
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    Journal of Crohn's and Colitis.2021; 15(1): 152.     CrossRef
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  • Diagnostic Accuracy of Fecal Calprotectin for the Detection of Small Bowel Crohn's Disease through Capsule Endoscopy: An Updated Meta-Analysis and Systematic Review
    Eun Suk Jung, Sang Pyo Lee, Sea Hyub Kae, Jung Han Kim, Hyeong Su Kim, Hyun Joo Jang
    Gut and Liver.2021; 15(5): 732.     CrossRef
  • Optimal Cutoff Level of Fecal Calprotectin for Detecting Small Bowel Inflammation in Crohn's Disease
    Eun Soo Kim
    Gut and Liver.2021; 15(5): 637.     CrossRef
  • Diagnostic Accuracy of Non-Invasive Imaging for Detection of Colonic Inflammation in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
    Meshari T. Alshammari, Rebecca Stevenson, Buraq Abdul-Aema, Guangyong Zou, Vipul Jairath, Shellie Radford, Luca Marciani, Gordon W. Moran
    Diagnostics.2021; 11(10): 1926.     CrossRef
  • Közös felelősség a gyulladásos bélbetegség diagnosztikájában és kezelésében.
    Dóra Dohos, Adrienn Erős, Kata Szemes, Patrícia Sarlós
    Orvosi Hetilap.2021; 162(33): 1311.     CrossRef
  • Crohn's Disease Activity Quantified by Iodine Density Obtained From Dual-Energy Computed Tomography Enterography
    Bari Dane, Sean Duenas, Joseph Han, Thomas O'Donnell, Justin Ream, Shannon Chang, Alec Megibow
    Journal of Computer Assisted Tomography.2020; 44(2): 242.     CrossRef
  • Defining the Path Forward for Biomarkers to Address Unmet Needs in Inflammatory Bowel Diseases
    Gerard Honig, Caren Heller, Andrés Hurtado-Lorenzo
    Inflammatory Bowel Diseases.2020; 26(10): 1451.     CrossRef
  • Multiomic features associated with mucosal healing and inflammation in paediatric Crohn’s disease
    Henry Taylor, Jose Ivan Serrano‐Contreras, Julie A. K. McDonald, Jenny Epstein, JM Fell, Rocio C. Seoane, Jia V. Li, Julian R. Marchesi, Ailsa L. Hart
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  • Nested case-control study on risk factors for opportunistic infections in patients with inflammatory bowel disease
    Shan-Shan Gong, Yi-Hong Fan, Qing-Qing Han, Bin Lv, Yi Xu
    World Journal of Gastroenterology.2019; 25(18): 2240.     CrossRef
  • Clinical value of fecal calprotectin
    Amanda Ricciuto, Anne M. Griffiths
    Critical Reviews in Clinical Laboratory Sciences.2019; 56(5): 307.     CrossRef
  • 13,412 View
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Editorial
IBD
Can vitamin D supplementation help control inflammation in inflammatory bowel disease beyond its classical role in bone health?
Sung Wook Hwang
Intest Res 2019;17(2):157-159.   Published online April 24, 2019
DOI: https://doi.org/10.5217/ir.2019.00038
PDFPubReaderePub

Citations

Citations to this article as recorded by  
  • High Risk of Fractures Within 7 Years of Diagnosis in Asian Patients With Inflammatory Bowel Diseases
    Hyung Jin Ahn, Ye-Jee Kim, Ho-Su Lee, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Beom-Jun Kim, Sang Hyoung Park
    Clinical Gastroenterology and Hepatology.2022; 20(5): e1022.     CrossRef
  • Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss
    Ya-Li Zhang, Qian Chen, Lie Zheng, Zi-Wei Zhang, Yu-Jun Chen, Yan-Cheng Dai, Zhi-Peng Tang
    World Journal of Gastroenterology.2022; 28(13): 1315.     CrossRef
  • IS DAIRY FOODS RESTRICTION MANDATORY FOR INFLAMMATORY BOWEL DISEASE PATIENTS: A MULTINATIONAL CROSS-SECTIONAL STUDY
    Pezhman ALAVINEJAD, Morteza NAYEBI, Abazar PARSI, Farnaz FARSI, Fatemeh MAGHOOL, Zeinab ALIPOUR, Mehdi ALIMADADI, Mohammed Hussien AHMED, Bahman CHERAGHIAN, Dao Viet HANG, Shabnam SHAHROKH, Mohammad Hasan EMAMI, Seyed Jalal HASHEMI, Mohamed ALBORAIE, Damo
    Arquivos de Gastroenterologia.2022; 59(3): 358.     CrossRef
  • Influence of Severe Vitamin D Deficiency on the Clinical Course of Inflammatory Bowel Disease
    Nam Seok Ham, Sung Wook Hwang, Eun Hye Oh, Jeongseok Kim, Ho-Su Lee, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang
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  • Influence of Severe Vitamin D Deficiency on the Clinical Course of Inflammatory Bowel Disease
    Cong Dai, Min Jiang
    Digestive Diseases and Sciences.2021; 66(3): 919.     CrossRef
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    Omid Asbaghi, Mehdi Sadeghian, Hassan Mozaffari-Khosravi, Vahid Maleki, Azad Shokri, Fatemeh Hajizadeh-Sharafabad, Mohammad Alizadeh, Omid Sadeghi
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  • 5,912 View
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Images of the Issue
Miscellaneous
A striking flail chest: a rare manifestation of intestinal disease
Shuang Liu, Ge Chong Ruan, Yan You, Jia Ming Qian, Ji Li
Intest Res 2019;17(1):155-156.   Published online December 14, 2018
DOI: https://doi.org/10.5217/ir.2018.00132
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Citations

Citations to this article as recorded by  
  • Cronkhite–Canada syndrome: from clinical features to treatment
    Ze-Yu Wu, Li-Xuan Sang, Bing Chang
    Gastroenterology Report.2020; 8(5): 333.     CrossRef
  • 6,057 View
  • 103 Download
  • 1 Web of Science
  • 1 Crossref
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Letters to the Editor
IBD
The optimal time to perform an ophthalmic examination of patients with inflammatory bowel disease
Ana Luiza Biancardi, Leandro Lopes Troncoso, Haroldo Vieira de Moraes Jr, Cyrla Zaltman
Intest Res 2019;17(1):153-154.   Published online December 14, 2018
DOI: https://doi.org/10.5217/ir.2018.00147
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  • 5,496 View
  • 97 Download
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Brief Communication
Infection
Gastrointestinal histoplasmosis: a case series from a non-endemic region in North India
Harshal S Mandavdhare, Jimil Shah, Kaushal K Prasad, Roshan Agarwala, Vikas Suri, Savita Kumari, Usha Dutta, Vishal Sharma
Intest Res 2019;17(1):149-152.   Published online October 16, 2018
DOI: https://doi.org/10.5217/ir.2018.00111
PDFPubReaderePub

Citations

Citations to this article as recorded by  
  • Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021
    Bassey E. Ekeng, Asa E. Itam-Eyo, Iriagbonse I. Osaigbovo, Adilia Warris, Rita O. Oladele, Felix Bongomin, David W. Denning
    Life.2023; 13(3): 689.     CrossRef
  • Isolated Colonic Histoplasmosis in Patients Undergoing Immunomodulator Therapy: A Systematic Review
    Faisal Inayat, Gul Nawaz, Arslan Afzal, Maleeha Ajmal, Marjan Haider, Muhammad Sarfraz, Zaka Ul Haq, Sobaan Taj, Rizwan Ishtiaq
    Journal of Investigative Medicine High Impact Case Reports.2023;[Epub]     CrossRef
  • An Unusual Discovery of Multi-Opportunistic Organisms in Gastrointestinal Biopsies of a Patient With Acquired Immunodeficiency Syndrome and Infectious Colitis
    Chirag Patel, Patricia Le, Malik Salman, Stephen Cavalieri, Joyce Kovar
    Cureus.2023;[Epub]     CrossRef
  • A case report of gastrointestinal histoplasmosis in a patient treated with infliximab
    Berta Oliveras, Marc Albert, Carme López, Esther Fort, Laia Peries, Laia Gutiérrez, David Busquets, Hugo Uchima, Xavier Aldeguer, Virginia Piñol
    Clinical Journal of Gastroenterology.2021; 14(2): 690.     CrossRef
  • A case of gastrointestinal histoplasmosis with esophageal involvement
    Mathew Finniss, Paul Lewis, James Myers, Lamis Ibrahim, Paras Patel
    Clinical Journal of Gastroenterology.2020; 13(2): 173.     CrossRef
  • Ileocecal thickening: Clinical approach to a common problem
    Roshan Agarwala, Abhi K Singh, Jimil Shah, Harshal S Mandavdhare, Vishal Sharma
    JGH Open.2019; 3(6): 456.     CrossRef
  • 8,592 View
  • 187 Download
  • 7 Web of Science
  • 6 Crossref
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Case Report
IBD
Acute pancreatitis associated with indigo naturalis in pediatric severe Crohn’s disease
Hyeon-A Kim, Hyo-rim Suh, Ben Kang, Byung-Ho Choe, on behalf of Crohn’s and Colitis Association in DaeguGyeongbuk (CCAiD)
Intest Res 2019;17(1):144-148.   Published online October 16, 2018
DOI: https://doi.org/10.5217/ir.2018.00104
AbstractAbstract PDFPubReaderePub
The incidence of inflammatory bowel disease (IBD) is rapidly increasing worldwide. Indigo naturalis is known to have an antiinflammatory effect. Indigo naturalis has been traditionally used in the treatment of IBD in China and Japan. Currently, it is used as a primary or adjunctive drug in patients with ulcerative colitis. There are some reports of the effects of indigo naturalis when used in patients with ulcerative colitis. However, its usage has been associated with adverse events, including liver dysfunction, headache, gastrointestinal disturbance, and pulmonary hypertension. Pancreatitis as an adverse event during treatment using indigo naturalis has not yet been reported. We report a case of recurrent events of pancreatitis that occurred briefly after starting medication with indigo naturalis in a child with severe Crohn’s disease. The pancreatitis improved after indigo naturalis was discontinued in 2 events. This is the first case to report the association between pancreatitis and indigo naturalis in the English literature.

Citations

Citations to this article as recorded by  
  • One-year clinical efficacy and safety of indigo naturalis for active ulcerative colitis: a real-world prospective study
    Yuichi Matsuno, Takehiro Torisu, Junji Umeno, Hiroki Shibata, Atsushi Hirano, Yuta Fuyuno, Yasuharu Okamoto, Shin Fujioka, Keisuke Kawasaki, Tomohiko Moriyama, Tomohiro Nagasue, Keizo Zeze, Yoichiro Hirakawa, Shinichiro Kawatoko, Yutaka Koga, Yoshinao Oda
    Intestinal Research.2022; 20(2): 260.     CrossRef
  • Pancreatic Disorders in Children with Inflammatory Bowel Disease
    Piotr Jakimiec, Katarzyna Zdanowicz, Kamila Kwiatek-Sredzinska, Aleksandra Filimoniuk, Dariusz Lebensztejn, Urszula Daniluk
    Medicina.2021; 57(5): 473.     CrossRef
  • Accumulation mechanism of indigo and indirubin in Polygonum tinctorium revealed by metabolite and transcriptome analysis
    Wenjing Wang, Yuan Wu, Huihui Xu, Yuan Shang, Yichen Chen, Miaoer Yan, Zhaohui Li, David R. Walt
    Industrial Crops and Products.2019; 141: 111783.     CrossRef
  • 7,419 View
  • 171 Download
  • 4 Web of Science
  • 3 Crossref
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Original Articles
Colorectal neoplasia
Clinical features and outcomes in spontaneous intramural small bowel hematoma: cohort study and literature review
Eun Ae Kang, Seung Jun Han, Jaeyoung Chun, Hyun Jung Lee, Hyunsoo Chung, Jong Pil Im, Sang Gyun Kim, Joo Sung Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Hyun Chae Jung
Intest Res 2019;17(1):135-143.   Published online October 10, 2018
DOI: https://doi.org/10.5217/ir.2018.00085
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background/Aims
Spontaneous intramural small bowel hematoma (SISBH) is an extremely rare complication of anticoagulant or antiplatelet therapy. We assessed the clinical characteristics and outcomes of patients with SISBH according to the anatomical location of the hematoma.
Methods
From January 2003 to February 2016, medical records for all patients hospitalized for SISBH at 2 tertiary referral hospitals were retrospectively reviewed. The primary outcome was requirement for surgery.
Results
A total of 37 patients were enrolled. The mean age was 74.1 years. Among them, 33 patients (89.2%) were taking anticoagulant and/or antiplatelet agents. Duodenal intramural hematoma was detected in 4 patients (10.8%), jejunal in 16 (43.2%), and ileal in 17 (45.9%). Compared to jejunal and ileal involvement, duodenal intramural hematoma was significantly associated with high Charlson comorbidity index and low levels of white blood cells, hemoglobin, and platelets in the blood. SISBH in the duodenum was related to thrombocytopenia in 3 patients following systemic chemotherapy for malignancy. All patients with SISBH showed clinical improvement with conservative therapy. Mean length of hospital stay was 9.35 days. Independent predictors of a hospital stay of more than 7 days were body weight less than 60 kg (odds ratio [OR], 12.213; 95% confidence interval [CI], 1.755–84.998; P=0.011) and a history of cerebrovascular accidents (OR, 6.667; 95% CI, 1.121–39.650; P=0.037).
Conclusions
Compared to jejunal and ileal involvement, thrombocytopenia may result in spontaneous duodenal intramural hematoma among patients who are treated with systemic chemotherapy for malignancies. Patients with SISBH have excellent clinical outcomes with conservative therapy regardless of the anatomical location of the hematoma.

Citations

Citations to this article as recorded by  
  • A Case of Direct-Acting Oral Anticoagulant-Induced Intramural Colon Hematoma Successfully Treated by Laparoscopic Surgery
    Daisuke Tomita, Shigeo Toda, Ryo Miyazaki, Shuichiro Matoba, Hiroya Kuroyanagi
    Cureus.2024;[Epub]     CrossRef
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    Sigrid L. Williamson, Aishwarya Suresh, Adrian Ong
    The American Surgeon™.2023; 89(6): 2816.     CrossRef
  • Intramural duodenal hematoma: diagnosis and management of a rare entity
    Álvaro Pérez-Rubio, Juan Carlos Sebastián-Tomás, Sergio Navarro-Martínez, Marta Córcoles Córcoles, Carlos Domingo del Pozo
    Cirugía Española (English Edition).2023; 101(7): 515.     CrossRef
  • Hematoma intramural duodenal: diagnóstico y manejo de una entidad infrecuente
    Álvaro Pérez-Rubio, Juan Carlos Sebastián-Tomás, Sergio Navarro-Martínez, Marta Córcoles Córcoles, Carlos Domingo del Pozo
    Cirugía Española.2023; 101(7): 515.     CrossRef
  • Jejunal intramural haematoma in a captive African lion (Panthera leo)
    Richelle G. Butcher, Baukje Lenting, Alison S. Clarke, Kelly Buckle, Cristina Gans
    Veterinary Record Case Reports.2023;[Epub]     CrossRef
  • Spontaneous Duodenal Hematoma: A Rare Complication of Triple Antithrombotic Therapy Case Report
    Mazin N Habhab, Asad J Torabi, Julie M Clary, George E Revtyak
    Future Cardiology.2023; 19(2): 71.     CrossRef
  • Intestinal Spontaneous Intramural Hematoma Secondary to Anticoagulation Therapy: A Case Report
    Karim El Aidaoui, Wahib Lahlou, Abderrahim Bourial, Nawal Bouknani, Chafik El Kettani
    Cureus.2023;[Epub]     CrossRef
  • Intramural Hematoma of Gastrointestinal Tract in People with Hemophilia A and B
    Wei-Jung Teng, Ching-Huei Kung, Mei-Mei Cheng, Jia-Ruey Tsai, Chia-Yau Chang
    Journal of Clinical Medicine.2023; 12(9): 3093.     CrossRef
  • Endoscopic management of intramural spontaneous duodenal hematoma: A case report
    Giorgio Valerii, Vittorio Maria Ormando, Carlo Cellini, Luca Sacco, Carmelo Barbera
    World Journal of Gastroenterology.2022; 28(20): 2243.     CrossRef
  • Warfarin-induced spontaneous intramural small bowel hematoma presenting as an acute abdomen: A case report
    Ding-Han Chen, Khay-Seng Soh, Ying-Tso Wang, Te-Chun Shen
    Medicine.2022; 101(35): e30335.     CrossRef
  • Spontaneous duodenal haematoma in a patient taking rivaroxaban
    Rebeca de Barros Lopes, Finn McLennan Battleday, Toby Calvert, Rob Gwynne‐Jones, Rebecca Thomas
    ANZ Journal of Surgery.2021;[Epub]     CrossRef
  • SPONTANEOUS INTRAMURAL SMALL-BOWEL HEMATOMA: A CAUSE OF ACUTE ABDOMEN IN ANTICOAGULATED PATIENTS
    Sergio Gil Rojas, Luis Miguel Estela Villa, Elsa María Jiménez Vicente
    Revista Española de Enfermedades Digestivas.2021;[Epub]     CrossRef
  • Small Bowel Obstruction
    Allison A. Aka, Jesse P. Wright, Teresa DeBeche-Adams
    Clinics in Colon and Rectal Surgery.2021; 34(04): 219.     CrossRef
  • Double Trouble: Spontaneous Duodenal Hematoma of Pancreatic Origin
    Luísa Martins Figueiredo, David Valadas Horta, Jorge A. Reis
    GE - Portuguese Journal of Gastroenterology.2019; 26(6): 458.     CrossRef
  • 28,071 View
  • 255 Download
  • 17 Web of Science
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Endoscopy
Clinicopathological feature and treatment outcome of patients with colorectal laterally spreading tumors treated by endoscopic submucosal dissection
Young-Hoon Jeong, Jun Lee, Sang-Wook Kim, Geom-Seog Seo, Hyun-Soo Kim, Young-Eun Joo
Intest Res 2019;17(1):127-134.   Published online October 10, 2018
DOI: https://doi.org/10.5217/ir.2018.00075
AbstractAbstract PDFPubReaderePub
Background/Aims
Endoscopic submucosal dissection (ESD) is an advanced technique that can be used to treat precancerous and early colorectal neoplasms by facilitating en bloc resection regardless of tumor size. In our study, we investigated the clinicopathological feature and the treatment outcome of patients with colorectal laterally spreading tumors (LSTs) that were treated by ESD.
Methods
The study enrolled all of 210 patients with colorectal LSTs who underwent ESD. Clinical outcomes were analyzed by retrospectively reviewing medical records.
Results
A cancerous pit pattern (Vi/Vn) was more common in pseudo-depressed (PD) subtype than in flat elevated (FE) subtype. The incidence of adenocarcinoma in the PD subtype and nodular mixed (NM) subtypes was significantly higher than in the homogenous (HG) subtype and FE subtype. The en bloc and R0 resection rates were 89.0% and 85.7%, respectively. The bleeding and perforation rates were 5.2% and 1.9%, respectively. The mean procedure time was much longer in the PD subtype than in the FE subtype. The en bloc resection rate was significantly higher in the NM subtype than in the HG subtype. However, there were no statistically significant differences in mean procedure time, en bloc resection rate, R0 resection rate, bleeding rate, or perforation rate between LST-granular and LST-nongranular types.
Conclusions
These results indicate that ESD is acceptable for treating colorectal LSTs concerning en bloc resection, curative resection, and risk of complications. Careful consideration is required for complete resection of the PD subtype and NM subtype because of their higher malignant potential.

Citations

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    Feng Gu, Wei Jiang, Jingyi Zhu, Lei Ma, Boyuan He, Huihong Zhai
    Digestive and Liver Disease.2024; 56(8): 1288.     CrossRef
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    Seong-Jung Kim, Su Young Kim, Jun Lee
    Surgical Endoscopy.2022; 36(8): 6243.     CrossRef
  • Blue laser imaging combined with JNET (Japan NBI Expert Team) classification for pathological prediction of colorectal laterally spreading tumors
    Si-lin Huang, Wen-xin Tan, Qun Peng, Wen-hua Zhang, Hai-tao Qing, Qiang Zhang, Jun Wu, Liang-dou Lin, Zhi-bin Lu, Yu Chen, Wei-guang Qiao
    Surgical Endoscopy.2021; 35(10): 5430.     CrossRef
  • Comparison of long-term recurrence-free survival between primary surgery and endoscopic resection followed by secondary surgery in T1 colorectal cancer
    Eun Hye Oh, Nayoung Kim, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Seung-Jae Myung, Suk-Kyun Yang, Chang Sik Yu, Jin Cheon Kim, Jeong-Sik Byeon
    Gastrointestinal Endoscopy.2021; 94(2): 394.     CrossRef
  • Second-look endoscopy findings after endoscopic submucosal dissection for colorectal epithelial neoplasms
    Soo-kyung Park, Hyeon Jeong Goong, Bong Min Ko, Haewon Kim, Hyo Sun Seok, Moon Sung Lee
    The Korean Journal of Internal Medicine.2021; 36(5): 1063.     CrossRef
  • 7,349 View
  • 206 Download
  • 6 Web of Science
  • 5 Crossref
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Endoscopy
The current capacity and quality of colonoscopy in Korea
Jae Ho Choi, Jae Myung Cha, Jin Young Yoon, Min Seob Kwak, Jung Won Jeon, Hyun Phil Shin
Intest Res 2019;17(1):119-126.   Published online October 10, 2018
DOI: https://doi.org/10.5217/ir.2018.00060
AbstractAbstract PDFPubReaderePub
Background/Aims
Little is known for the capacity and quality of colonoscopy, and adherence to colonoscopy surveillance guidelines in Korea. This study aimed to investigate the present and potential colonoscopic capacity, colonoscopic quality, and adherence to colonoscopy surveillance guidelines in Korea.
Methods
We surveyed representative endoscopists of 72 endoscopy units from June to August 2015, using a 36-item questionnaire regarding colonoscopic capacity, quality, and adherence to colonoscopy surveillance guidelines of each hospitals.
Results
Among the 62 respondents who answered the questionnaire, 51 respondents were analyzed after exclusion of 11 incomplete answers. Only 1 of 3 of endoscopy units can afford to perform additional colonoscopies in addition to current practice, and the potential maximum number of colonoscopies per week was only 42. The quality of colonoscopy was variable as reporting of quality indicators of colonoscopy were considerably variable (29.4%–94.1%) between endoscopy units. Furthermore, there are substantial gaps in the adherence to colonoscopy surveillance guidelines, as concordance rate for guideline recommendation was less than 50% in most scenarios.
Conclusions
The potential capacity and quality of colonoscopy in Korea was suboptimal. Considering suboptimal reporting of colonoscopic quality indicators and low adherence rate for colonoscopy surveillance guidelines, quality improvement of colonoscopy should be underlined in Korea.

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