Intestinal Research

Immunological Abnormalities in the Pathogenesis of Inflammatory Bowel Disease: Tadakazu Hisamatsu, Yohei Mikami, Katsuyoshi Matsuoka, Takanori Kanai, Toshifumi Hibi; Intest Res 2012;10(4):317-323. Published online October 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.4.317

Crohn's disease and ulcerative colitis represent two distinct forms of inflammatory bowel diseases (IBD). In this paper, we discuss how immunological mechanisms contribute to the pathogenesis of IBD. Intestinal homeostasis is sustained by various kinds of cells, such as epithelial cells, lymphocytes, antigen presenting cells, and other innate immune cells. We pay special attention to intestinal CD14+ macrophages. Intestinal macrophages play a central role in the regulation of immune responses against commensal bacteria. In the physiological condition, intestinal macrophages lack the expression of innate-immune receptor CD14 and do not produce proinfl ammatory cytokines. We identified a unique macrophage subset of IBD in the human intestine, which expressed both macrophage (CD14, CD33, CD68) and dendritic cell (DC) markers (CD205, CD209) and produced larger amounts of proinflammatory cytokines, such as interleukin (IL)-23 and tumor necrosis factor (TNF)-Ձ. In addition, the CD14+ macrophages contributed to interferon (IFN)-Ճ production rather than IL-17 production by lamina propria mononuclear cells dependent on IL-23. We discuss herein this IL-23/IFN-Ճ-positive feedback loop in IBD patients. We also discuss IFN-Ճ and IL-17 production from mucosal T cells and natural killer (NK) cells. Here, we show our recent findings about the plasticity of T helper cells in colitis. Th 17 cells express T-bet, and finally lose the expression of retinoic acid-related orphan receptor (ROR)Ճt, the master regulator of Th 17 cells, and are differentiated 'alternative Th 1 cells.' In addition to Th 1 cells, mucosal NK cells are also important sources of IFN-Ճ. Some of our ideas may be provocative, but we hope this review paper will provide new and firm understanding of the pathogenesis of IBD. (Intest Res 2012;10:317-323)

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Does Carotid Intima-Media Thickness Increase in Patients With Inflammatory Bowel Disease?
Kyeong Ok Kim, Byung Ik Jang, Si Hyung Lee
Intestinal Research.2014; 12(4): 293. CrossRef
Intravenousvsintraperitoneal mesenchymal stem cells administration: What is the best route for treating experimental colitis?
Fabiany da Costa Gonçalves
World Journal of Gastroenterology.2014; 20(48): 18228. CrossRef
Current issues of pediatric inflammatory bowel disease in Korea
Seak Hee Oh, Kyung Mo Kim
Korean Journal of Pediatrics.2014; 57(11): 465. CrossRef

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MicroRNA Dysregulations in Gastrointestinal Cancers: Pathophysiological and Clinical Perspectives: William KK Wu, Joseph JY Sung; Intest Res 2012;10(4):324-331. Published online October 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.4.324

Abstract PDF

Two common gastrointestinal cancers, namely, gastric and colorectal cancers, cause high mortality and morbidity. The development of gastrointestinal cancers usually follows stepwise processes with recognizable pre-neoplastic changes. A class of noncoding RNA known as microRNA (miRNA) is increasingly recognized to play pleiotropic functions in the multistep development of gastrointestinal cancers. Abnormal patterns of miRNA expression in gastric and colorectal cancers have been widely reported. These dysregulated miRNAs function as novel proto-oncogenes and tumor-suppressor genes by controlling cellular malignant phenotypes, including unchecked cell proliferation, resistance to apoptosis, enhanced invasiveness and metastasis, and angiogenesis. Moreover, certain polymorphisms in miRNA genes or miRNA-binding sites are associated with disease risks whereas detection of circulating or fecal miRNAs may facilitate early diagnosis. The prognostic functions of a number of dysregulated miRNAs in gastrointestinal cancers have also been established. Delineating the pathophysiological basis of miRNA dysregulation will further our understanding of the pathogenesis of these two potentially fatal diseases. Such efforts will also result in the development of miRNA-based biomarkers and therapeutics for the risk stratification, diagnosis, prognostication, and treatment of gastrointestinal cancers. (Intest Res 2012;10:324-331)

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MicroRNA-30a-5p (miR-30a) regulates cell motility and EMT by directly targeting oncogenic TM4SF1 in colorectal cancer
Y. R. Park, S. L. Kim, M. R. Lee, S. Y. Seo, J. H. Lee, S. H. Kim, I. H. Kim, S. O. Lee, S. T. Lee, Sang Wook Kim
Journal of Cancer Research and Clinical Oncology.2017; 143(10): 1915. CrossRef
MicroRNA-30a Inhibits Colorectal Cancer Metastasis Through Down-Regulation of Type I Insulin-Like Growth Factor Receptor
Y. C. Liu, Y. R. Park, S. L. Kim, S. T. Lee, S. W. Kim
Digestive Diseases and Sciences.2017; 62(11): 3040. CrossRef
Clinical Application of Genetics in Management of Colorectal Cancer
Eun Ran Kim, Young-Ho Kim
Intestinal Research.2014; 12(3): 184. CrossRef

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Central Nervous System and the Colonic Bioreactor: Analysis of Colonic Microbiota in Patients with Stroke Unravels Unknown Mechanisms of the Host Defense after Brain Injury: Alexander Swidsinski, Vera Loening-Baucke, Monika Krüger, Steffen Kirsch; Intest Res 2012;10(4):332-342. Published online October 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.4.332

Abstract PDF

Background/Aims
Stroke is accompanied by septic complications due to quickly changing polymicrobials of unclear origin. This study was aimed to find the source of stroke-associated-infections. Methods: We investigated the biostructure of the colonic microbiota in patients hospitalized in two stroke units using fluorescence in situ hybridization in order to find the source of stroke-associated-infections. Non-stroke subjects and animals were used as controls. Results: Typical for stroke was a leukocyte migration into the mucus between day 1-3, in numbers that are otherwise characteristic for active ulcerative colitis (CAI ≥6); subsequent abrupt "decontamination" of the main fermentative Roseburia, Bacteroides and Faecalibacterium prausnitzii groups and disappearance of leukocytes in the stool; arrest of bacterial fermentation between day 3 to 7 in extents exceeding the effects of any presently know antibiotics. Then resetting in which Enterobacteriaceae, Bifidobacteriaceae and Clostridium difficile temporarily outnumber Bacteroides, Roseburia and Faecalibacterium prausnitzii, and after that decline with normalization of these bacteria to initial values. Conclusions: The colon is a bioreactor containing many potential pathogens. The mucus barrier shields the host from bacteria. The events following stroke stress the pivotal role of the brain in maintaining this shield and indicate an existence of emergency brakes that temporary terminate the biofermentation. (Intest Res 2012;10:332-342)

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The Influence of Gut Dysbiosis in the Pathogenesis and Management of Ischemic Stroke
Saravana Babu Chidambaram, Annan Gopinath Rathipriya, Arehally M. Mahalakshmi, Sonali Sharma, Tousif Ahmed Hediyal, Bipul Ray, Tuladhar Sunanda, Wiramon Rungratanawanich, Rajpal Singh Kashyap, M. Walid Qoronfleh, Musthafa Mohamed Essa, Byoung-Joon Song, T
Cells.2022; 11(7): 1239. CrossRef
Intestinal microbiota research from a global perspective
Jordyn T Wallenborn, Pascale Vonaesch
Gastroenterology Report.2022;[Epub] CrossRef
Role of gut microbiota in neuropathy and neuropathic pain states: A systematic preclinical review
Katia Pane, Serena Boccella, Francesca Guida, Monica Franzese, Sabatino Maione, Marco Salvatore
Neurobiology of Disease.2022; 170: 105773. CrossRef
Systemic inflammation after stroke: implications for post‐stroke comorbidities
Alba Simats, Arthur Liesz
EMBO Molecular Medicine.2022;[Epub] CrossRef
Age matters: Microbiome depletion prior to repeat mild traumatic brain injury differentially alters microbial composition and function in adolescent and adult rats
Marissa Sgro, Giulia Iacono, Glenn R. Yamakawa, Zoe N. Kodila, Benjamin J. Marsland, Richelle Mychasiuk, Farah Al-Marzooq
PLOS ONE.2022; 17(11): e0278259. CrossRef
Could the Gut Microbiota Serve as a Therapeutic Target in Ischemic Stroke?
Jiyao Zhang, Qiang Tang, Luwen Zhu, San Jun Shi
Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1. CrossRef
Intestinal Barrier Dysfunction Participates in the Pathophysiology of Ischemic Stroke
Minping Wei, Qin Huang, Zeyu Liu, Yunfang Luo, Jian Xia
CNS & Neurological Disorders - Drug Targets .2021; 20(5): 401. CrossRef
Nutritional support for patients in the neurosurgical and neurological intensive care unit: are special guidelines necessary?
Kirill Iu. Krylov, Sergey V. Sviridov, Ivan A. Savin
Clinical nutrition and metabolism.2021; 2(3): 173. CrossRef
Imbalance in the force: the dark side of the microbiota on stroke risk and progression
Kathryn Prame Kumar, Connie HY Wong
Current Opinion in Neurobiology.2020; 62: 10. CrossRef
Fecal Microbiota Transplantation in Neurological Disorders
Karuna E. W. Vendrik, Rogier E. Ooijevaar, Pieter R. C. de Jong, Jon D. Laman, Bob W. van Oosten, Jacobus J. van Hilten, Quinten R. Ducarmon, Josbert J. Keller, Eduard J. Kuijper, Maria Fiorella Contarino
Frontiers in Cellular and Infection Microbiology.2020;[Epub] CrossRef
Nutritive rehabilitation of the patients after recovering from coma
M. V. Petrova, A. E. Shestopalov, A. V. Yakovleva, K. Yu. Krylov, E. M. Mengistu
Physical and rehabilitation medicine, medical rehabilitation.2020; 2(1): 28. CrossRef
Dynamic Changes in the Gut Microbiome at the Acute Stage of Ischemic Stroke in a Pig Model
Julie Jeon, Jeferson Lourenco, Erin E. Kaiser, Elizabeth S. Waters, Kelly M. Scheulin, Xi Fang, Holly A. Kinder, Simon R. Platt, Michael J. Rothrock, Todd R. Callaway, Franklin D. West, Hea Jin Park
Frontiers in Neuroscience.2020;[Epub] CrossRef
The role of indirect calorimetry in the treatment and rehabilitation of patients in long-term unconsciousness after brain damage
Kirill Yu. Krylov, Ivan V. Sergeev, Alexandra V. Yakovleva, Ruben S. Yagubyan, Alexey A. Yakovlev, Marina V. Petrova
Clinical nutrition and metabolism.2020; 1(1): 10. CrossRef
Microbial Peer Pressure
Rikeish R. Muralitharan, Hamdi A. Jama, Liang Xie, Alex Peh, Matthew Snelson, Francine Z. Marques
Hypertension.2020; 76(6): 1674. CrossRef
Short-Chain Fatty Acids Improve Poststroke Recovery via Immunological Mechanisms
Rebecca Sadler, Julia V. Cramer, Steffanie Heindl, Sarantos Kostidis, Dene Betz, Kielen R. Zuurbier, Bernd H. Northoff, Marieke Heijink, Mark P. Goldberg, Erik J. Plautz, Stefan Roth, Rainer Malik, Martin Dichgans, Lesca M. Holdt, Corinne Benakis, Martin
The Journal of Neuroscience.2020; 40(5): 1162. CrossRef
Higher Risk of Stroke Is Correlated With Increased Opportunistic Pathogen Load and Reduced Levels of Butyrate-Producing Bacteria in the Gut
Xiuli Zeng, Xuxuan Gao, Yu Peng, Qiheng Wu, Jiajia Zhu, Chuhong Tan, Genghong Xia, Chao You, Ruoting Xu, Suyue Pan, Hongwei Zhou, Yan He, Jia Yin
Frontiers in Cellular and Infection Microbiology.2019;[Epub] CrossRef
Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke
Geng-Hong Xia, Chao You, Xu-Xuan Gao, Xiu-Li Zeng, Jia-Jia Zhu, Kai-Yu Xu, Chu-Hong Tan, Ruo-Ting Xu, Qi-Heng Wu, Hong-Wei Zhou, Yan He, Jia Yin
Frontiers in Neurology.2019;[Epub] CrossRef
The bidirectional gut-brain-microbiota axis as a potential nexus between traumatic brain injury, inflammation, and disease
Mark H. Sundman, Nan-kuei Chen, Vignesh Subbian, Ying-hui Chou
Brain, Behavior, and Immunity.2017; 66: 31. CrossRef
Gut microbiota impact on stroke outcome: Fad or fact?
Katarzyna Winek, Andreas Meisel, Ulrich Dirnagl
Journal of Cerebral Blood Flow & Metabolism.2016; 36(5): 891. CrossRef
The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke
Katarzyna Winek, Ulrich Dirnagl, Andreas Meisel
Neurotherapeutics.2016; 13(4): 762. CrossRef
Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke
Katarzyna Winek, Odilo Engel, Priscilla Koduah, Markus M. Heimesaat, André Fischer, Stefan Bereswill, Claudia Dames, Olivia Kershaw, Achim D. Gruber, Caterina Curato, Naoki Oyama, Christian Meisel, Andreas Meisel, Ulrich Dirnagl
Stroke.2016; 47(5): 1354. CrossRef

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The Rebleeding Risk and Prognostic Factors of Acute Hemorrhagic Rectal Ulcer: Bun Kim, Min Seok Han, Dong Hoo Joh, Dong Jun Lee, Hye Sun Shin, Soo Jung Park, Sung Pil Hong, Jae Hee Cheon, Tae Il Kim, Won Ho Kim; Intest Res 2012;10(4):343-349. Published online October 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.4.343

Abstract PDF

Background/Aims
Acute hemorrhagic rectal ulcer (AHRU) is an important etiology of lower gastrointestinal bleeding in intensive care unit patients and hospital inpatients. Moreover, with increasing elderly populations, and improved survival in critically ill patients, the incidence of AHRU has increased. The aim of this study is to determine rebleeding risk and prognostic factors of AHRU patients. Methods: We retrospectively reviewed 32 patients with AHRU in Severance Hospital from February 2006 to October 2010, collected clinical data, and analyzed their association with the recurrence of bleeding and mortality of patients. Results: The mean age of patients was 65.5 years, and 27 patients (84.4%) showed Eastern Cooperative Oncology Group performance status 3-4. Nineteen patients (59.4%) had recurrent bleeding. Hypoalbuminemia (≤2.5 g/dL) was a risk factor of rebleeding in univariate and multivariate analysis. For patients with chronic liver disease, hypoalbuminemia (≤2.5 g/dL), renal dysfunction (>2 mg/dL) and thrombocytopenia (<150,000/ՌL) showed relatively earlier rebleeding than those without (P=0.007, P=0.009, P=0.027 and P=0.043, respectively). The endoscopic hemostasis at the first bleeding event was associated with lower early rebleeding rate (P=0.048). In univariate analysis, chronic liver disease, hypoalbuminemia (≤2.5 g/dL) and the prolongation of activated partial thromboplastin time (>40 seconds) increased mortality (P=0.028, P=0.008 and P=0.027, respectively) and the patients with rebleeding showed a tendency toward higher mortality, compared to those without (57.9% vs. 23.1%, P=0.051). Conclusions: In AHRU patients, hypoalbuminemia was a risk factor of rebleeding, and chronic liver disease, hypoalbuminemia, renal dysfunction, thrombocytopenia and no endoscopic treatment at the first bleeding event was correlated with relatively earlier rebleeding. (Intest Res 2012;10:343-349)

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Rebleeding Risk of Acute Hemorrhagic Rectal Ulcer: A Multicenter Retrospective Study
Takahiro Muramatsu, Masakatsu Fukuzawa, Akira Madarame, Yasuyuki Kagawa, Miho Kikuchi, Sho Taniguchi, Satoshi Shimai, Sho Matsumoto, Fumito Yamanishi, Yuka Suzuki, Daiki Nemoto, Hirokazu Shinohara, Taisuke Matsumoto, Yohei Koyama, Kumiko Uchida, Hayato Ya
Internal Medicine.2024;[Epub] CrossRef
Acute hemorrhagic rectal ulcer syndrome: Comparison with non‐hemorrhagic rectal ulcer lower gastrointestinal bleeding
Joo Hyuk Jung, Jong Wook Kim, Hyun Woo Lee, Min Yong Park, Woo Hyun Paik, Won Ki Bae, Nam‐Hoon Kim, Kyung‐Ah Kim, June Sung Lee
Journal of Digestive Diseases.2017; 18(9): 521. CrossRef

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Clinical Significance of Erosive or Ulcerative Lesions Isolated in Terminal Ileum: Sun Ok Kwon, You Sun Kim, Myoung Ki Oh, Sun Young Kim, In Hye Cha, Seong Yeon Jeong, Joo Yeon Cho, Jin Nam Kim, Jeong Seop Moon; Intest Res 2012;10(4):350-356. Published online October 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.4.350

Abstract PDF: Background/Aims
Although terminal ileal erosive or ulcerative lesions are frequently observed on colonoscopic examination, their clinical significance are unclear. We evaluated clinical course and significance of isolated terminal ileal erosive or ulcerative lesions. Methods: We retrospectively analyzed clinical features, number, size and histologic findings of 186 patients with isolated terminal ileal erosive or ulcerative lesions on colonoscopic examination from December 2003 to February 2012. Results: The indications for colonoscopy included screening for colorectal cancer or surveillance in 122 patients (65.6%), evaluations for symptoms in 64 patients (34.4%). Of the 186 patients, 170 underwent biopsy at the terminal ileal lesions. Histologic findings were mostly non-specific chronic inflammation except two cases of Crohn's disease, one case of cytomegalovirus ileitis, and one case of intestinal tuberculosis. Forty six patients underwent follow-up colonoscopy and the mean duration was 17.8±14.2 months (range, 1-64 months). Of those who showed non-specific ileitis (44 patients), 35 (79.5%) showed resolution of lesions without specific treatment. In the remaining 9 (20.5%) patients, lesions were continued and two patients were diagnosed as Crohn's disease and Behcet's ileitis, respectively. There were no significant differences in the duration of follow-up, presence of symptoms, number and size of terminal ileal lesions between the patients who resolved and not resolved. Conclusions: Most isolated terminal ileal erosive or ulcerative lesions reveal non-specific histological findings and have a propensity to resolve without treatment. However, in small portions of patients, isolated terminal ileal lesions need careful attention because it is possible to be early inflammatory bowel diseases. (Intest Res 2012;10:350-356)

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Synergistic Effect of Parthenolide in Combination with 5-Fluorouracil in SW480 Cells: Se-Lim Kim, Thu Trang Thi Kieu , Byung Jun Jeon, Seong Hun Kim, In Hee Kim, Seung Ok Lee, Soo Teik Lee, Sang Wook Kim; Intest Res 2012;10(4):357-364. Published online October 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.4.357

Abstract PDF

Background/Aims
Parthenolide (PT) is responsible for the bioactivities of Feverfew. Besides its potent anti-inflammatory effect, this compound has recently been reported to induce apoptosis in cancer cells. Unfortunately, many of the therapies that use 5-fluorouracil (5-FU) alone or in combination with other agents are likely to become ineffective due to drug resistance. In the present study, we investigate the antitumor effect of PT combined with 5-FU on colorectal cancer cells. Methods: SW480 cell was employed as a representative of human colorectal carcinoma (CRC) cells. We performed MTT, annexin-V assay, and Hoechst 33258 staining to measure the synergistic effect. Western blotting was used to demonstrate apoptotic pathway. Results: Our result demonstrated that PT inhibited the viability of colorectal cancer cells and had synergistic anti-proliferation in combination with 5-FU. After combined treatment of 5-FU and PT, enhanced apoptotic cell death is observed using annexin-V FITC assay and it was revealed by the condensed chromatin and fragmented DNA. Compared with 5-FU or PT alone, the apoptosis of colorectal cancer cells treated with PT and 5-FU enhanced the activation of caspase-8, caspase-3. Conclusions: Combined treatment with PT may offer an efficacious strategy to overcome 5-FU resistance in certain CRC cells. (Intest Res 2012;10:357-364)

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Balsalazide Potentiates Parthenolide-Mediated Inhibition of Nuclear Factor-κB Signaling in HCT116 Human Colorectal Cancer Cells
Hyun-Young Kim, Se-Lim Kim, Young-Ran Park, Yu-Chuan Liu, Seung Young Seo, Seong Hun Kim, In Hee Kim, Seung Ok Lee, Soo Teik Lee, Sang Wook Kim
Intestinal Research.2015; 13(3): 233. CrossRef

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Clinicopathological Characteristics of Colorectal Cancer according to Gender Difference: Dae Ho Kim, Jae Myung Cha, Joung Il Lee, Kwang Ro Joo, Hyun Phil Shin, Jae Jun Park, Jung Won Jeon, Jun Uk Lim, Seung Jung Jun, Yoon Jong Seo; Intest Res 2012;10(4):365-371. Published online October 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.4.365

Abstract PDF

Background/Aims
Colorectal cancer (CRC) has been one of the major causes of death and has become a major public health concern. The incidence of CRC has been increasing regardless of gender in Korea. Until now, however, the studies on gender-based clinicopathological characteristics of CRC focused on pathology have never been reported. Therefore, we aimed to evaluate the difference in clinicopathological characteristics of CRC according to gender in Korea. Methods: Medical records of 342 patients with advanced CRC who underwent surgical resection at Kyung Hee University Hospital at Gangdong from June 2006 to December 2011 were retrospectively analyzed. The data of the clinicopathological characteristics of CRC by gender difference were compared. Results: Of these 341 patients, 203 (60%) patients were male and 138 (40%) patients were female. The male preponderance was noted in all age groups for total CRC and left-sided CRC. However, for right-sided colon cancer, this male preponderance was significantly decreased with increasing age groups (P=0.025) and was finally reversed in elderly groups (age ≥60 years). The microsatellite instability represented by negative staining for hMLH1 and hMSH2 was more frequently detected in women than men (P=0.037). Conclusions: The male preponderance in right-sided colon cancer decreased with increasing age groups and finally reversed in age groups more than 60 years. Microsatellite instability with immunohistochemical staining was more frequently detected in women. However, further studies with a large number of patients are warranted on this issue. (Intest Res 2012;10:365-371)

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Screening strategy for colorectal cancer according to risk
Dong Soo Han
Journal of the Korean Medical Association.2017; 60(11): 893. CrossRef
Prevalence, Clinicopathologic Characteristics, and Predictors of Interval Colorectal Cancers in Korean Population
Chang Joon Kim, Yoon Suk Jung, Jung Ho Park, Hong Joo Kim, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Shin Yeong Lee, Hwa Mok Kim, Ki Bae Bang, Dae Sung Lee, Dong Il Park
Intestinal Research.2013; 11(3): 178. CrossRef

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Clinical Comparison for Colon Polyps between Right and Left Colon in Koreans: Wook Hyun Um, Hyun Gun Kim, Seong Ran Jeon, Tae Hee Lee, Wan Jung Kim, Bong Min Ko, Jin-Oh Kim, Joo Young Cho, Joon Seong Lee, Moon Sung Lee; Intest Res 2012;10(4):372-378. Published online October 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.4.372

Abstract PDF

Background/Aims
Comparative studies of colon polyps between right and left colon in Korean population are limited. We investigated the clinical characteristics of the patients according to polyp location and compared the results of the morphological and histological analysis of right and left colon polyps. Methods: The study was performed prospectively for the patients who underwent colon polypectomy for health check-ups in a single tertiary center. The patients were classified into three groups by the location of the polyps: right group (from the cecum to the splenic flexure), left group (from the descending colon to the anus), and total group. The size, the morphology, the location and the pathology of the polyps were evaluated. Results: From June 2010 to June 2011, Overall 2596 polyps from 950 patients (male=646) were analyzed. Colon polyps were right side-shift with increased patients age (P<0.001). The incidence of polyps was most common in sigmoid colon (26.5%). Polyps less than 5 mm size were more common in left colon (P<0.001) and flat polyps larger than 1 cm in right colon (P=0.006), respectively. In histopathological findings, the distribution of advanced adenoma was not different according to the location, however tubular adenomas and serrated adenomas (P<0.001) were more common in right colon. Female was more distributed in right group, respectively (P<0.001). Conclusions: In a single center study, colon polyps were more distributed in right colon with age and in females. Also flat polyps larger than 1cm, tubular adenoma and serrated adenoma were found in larger proportion in right colon. (Intest Res 2012;10:372-378)

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Clinicopathological features of colorectal polyps in 2002 and 2012
Yoon Jeong Nam, Kyeong Ok Kim, Chan Seo Park, Si Hyung Lee, Byung Ik Jang
The Korean Journal of Internal Medicine.2019; 34(1): 65. CrossRef

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Rare Case of Ogilvie Syndrome Associated with Herpes Zoster: Ji Hyun Kim, Suck-Ho Lee, Gyeong Jae Na, Su Jin Lee, Yeong Geol Jo, Tae Hoon Lee, Il Kwun Chung, Sang Heum Park, Sun Joo Kim; Intest Res 2012;10(4):379-382. Published online October 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.4.379

Abstract PDF

Acute colonic pseudo-obstruction (Ogilvie syndrome) associated with herpes zoster is extremely rare, and few cases have been reported. An 81-year-old woman diagnosed with herpes zoster was referred for accompanying colonic ileus. The diameter of the cecum was 7 cm and a computed tomographic scan showed no definite obstructive cause. Because the patient showed minimal improvement with conservative treatment, endoscopic colonic decompression was performed successfully. Previous studies revealed that the treatment of Ogilvie syndrome associated with herpes zoster does not differ from that of other conditions, and the role of the varicella-zoster virus in this syndrome is unclear. Here, we present the first case of Ogilvie syndrome associated with herpes zoster in Korea, which was improved by endoscopic colonic decompression. (Intest Res 2012;10:379-382)

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Looking back to move forward: a twenty-year audit of herpes zoster in Asia-Pacific
Liang-Kung Chen, Hidenori Arai, Liang-Yu Chen, Ming-Yueh Chou, Samsuridjal Djauzi, Birong Dong, Taro Kojima, Ki Tae Kwon, Hoe Nam Leong, Edward M. F. Leung, Chih-Kuang Liang, Xiaohong Liu, Dilip Mathai, Jiun Yit Pan, Li-Ning Peng, Eduardo Rommel S. Poblet
BMC Infectious Diseases.2017;[Epub] CrossRef
Acute Colonic Pseudo-Obstruction (Ogilvie’s syndrome) as a Complication of Herpes Zoster
Kyung-Sun Min
The Korean Journal of Medicine.2016; 90(4): 318. CrossRef

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Drug Rash with Eosinophilia and Systemic Symptoms Syndrome in a Patient on Sulfasalazine for Ulcerative Colitis: Kyung Hwan Kang, Chang Kyun Lee, Hyo Jong Kim, Jaejun Shim, Jae Young Jang, Seok Ho Dong, Byung Ho Kim, Young Woon Chang; Intest Res 2012;10(4):383-387. Published online October 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.4.383

Abstract PDF: Drug rash with eosinophilia and systemic symptoms (DRESS) is a life-threatening systemic drug reaction characterized by fever, rash, hematological abnormalities, lymphadenopathy, and multiple internal organ involvement. Unfortunately, a long latency period as well as clinicians' unawareness of the disease entity often results in a delay of prompt diagnosis and treatment in clinical practice. A search of the literature revealed only few reports on DRESS in patients with inflammatory bowel diseases. The pathogenesis of the disease is not clearly understood, although several possible mechanisms, such as drug detoxification, slow acetylation, and reactivation of human herpes viruses, have been proposed in its development. Here, we present a rare case of DRESS associated with viral reactivation and defects in drug metabolism in a 22-year-old man who had been on sulfasalazine for 6 weeks to treat ulcerative colitis. (Intest Res 2012;10:383-387)

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A Case of Ulcerative Colitis Patient with Colonic Stenosis and Enterocutaneous Fistula: Seong Yeon Jeong, You Sun Kim, Kyeong Sam Ok, Sun Ok Kwon, Jin Nam Kim, Jeong Seop Moon, Yun Kyung Kang, Seong Woo Hong; Intest Res 2012;10(4):388-391. Published online October 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.4.388

Abstract PDF: Ulcerative colitis (UC) is one of the chronic inflammatory bowel diseases (IBD), characterized by a diffuse mucosal inflammation limited to the colon. Complications of UC include stricture, colorectal cancer, and toxic colitis. UC patients rarely present with a stenosis or fistula, and strictures develop in less than 5% of patients with UC. We present a patient with UC, accompanied by unusual complications that involved not only a stricture but also a fistula and abscess. A 49-year-old female was presented with a left flank pain and fever that had begun two weeks before admission. She had received a diagnosis of UC 20 years ago and had it treated for 2 years in a local hospital. However, she arbitrarily stopped visiting the hospital and relied on home remedies. An abdominopelvic CT scan revealed luminal narrowing and extra-peritoneal fistula formation in the descending colon. Fistula was connected with a subcutaneous abscess in the left flank. She had undergone total colectomy and ileo-anal anastomosis. On the pathologic exam, the long standing UC with severe stenosis was observed without malignant change. It cannot be emphasized enough that a correct therapeutic approach and an appropriate follow-up schedule are very important for patients with UC. (Intest Res 2012;10:388-391)

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A Case of Cholangiocarcinoma and Colorectal Cancer Diagnosed Simultaneously in a Patient with Ulcerative Colitis and Concurrent Primary Sclerosing Cholangitis: Eun Yeong Kim, Hyo Jong Kim, Chang Kyun Lee, Choul Ki Park, Hee Jae Hyun, Yeon Ju Kim, Kyung Yup Kim; Intest Res 2012;10(4):392-396. Published online October 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.4.392

Abstract PDF

Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) accompanied by a risk to develop colorectal dysplasia and cancer. Primary sclerosing cholangitis (PSC) is strongly associated with UC and there are some distinguishing clinical features between UC patients with PSC (UC-PSC) and UC patients without PSC. The most important feature is that UC patients with concomitant PSC are at a significantly increased risk of developing colorectal dysplasia or cancer. Furthermore, it has been suggested that patients with UC and PSC are also at an increased risk of cholangiocarcinoma. We report a case of cholangiocarcinoma and colorectal cancer diagnosed simultaneously in a patient with UC and concurrent PSC. He was diagnosed with UC and PSC 13 years ago and had been treated irregularly. Surveillance colonoscopy and biopsies were performed and one of the biopsied specimen confirmed adenocarcinoma. He underwent abdominal computed tomography (CT) because of the abnormal liver function test and the CT showed cholangiocarcinoma. To the best of our knowledge, this is the first case report of a UC-PSC with cholangiocarcinoma and colorectal cancer at the same time in Korea. (Intest Res 2012;10:392-396)

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Colon Cancer Screening and Surveillance in Inflammatory Bowel Disease
Song I Bae, You Sun Kim
Clinical Endoscopy.2014; 47(6): 509. CrossRef

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A Case of Adenocarcinoma of the Transverse Colon with Humoral Hypercalcemia of Malignancy: Jae Gon Lee, Dong Soo Han, Jae Ha Kim, You Shin Kim, Hyun Soo Kim, Jae Yoon Jeong, Ju Yeon Pyo, Yong Cheol Jeon, Joo Hyun Sohn; Intest Res 2012;10(4):397-399. Published online October 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.4.397

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Hypercalcemia is a common electrolyte imbalance in patients with malignancy. Approximately 80% of hypercalcemia is associated with humoral hypercalcemia of malignancy (HHM), but occurs rarely in colorectal carcinomas. A 72-year-old man was admitted with abdominal pain and bowel habit change. Colonoscopy showed a malignant tumor in the transverse colon. Laboratory data showed an elevated serum calcium level (11.6 mg/dL) and elevated parathyroid hormone-related peptide level (12.2 pmol/L). Histology showed poorly differentiated adenocarcinoma. We infused intravenous normal saline, furosemide and pamidronate. The serum calcium level was subsequently normalized. However, the patient died from cancer progression 10 days later. With a review of the relevant literature, we report a case of adenocarcinoma of the transverse colon with HHM. (Intest Res 2012;10:397-399)

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Esophageal Cancer Initially Presenting as Severe Paraneoplastic Hypercalcemia Requiring Hemodialysis
Hye Shin Ahn, Jong Min Yun, Yeong Bok Lee, Yu Mi Ko, Jung Eun Lee, Hye Sung Won, Sung Soo Kim, Young Ok Kim
The Korean Journal of Gastroenterology.2015; 65(6): 361. CrossRef

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Is It Safe for Patients with Inflammatory Bowel Disease to Go Abroad?: Eun Soo Kim; Intest Res 2012;10(4):400-401. Published online October 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.4.400

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TÜRKİYE-RUSYA İLİŞKİLERİ VE UÇAK KRİZİNİN RUS-TÜRK KAMUOYUNDAKİ YANSILARI
Vefa KURBAN, Hatem CABBARLI
Ege Stratejik Araştırmalar Dergisi.2019; 10(2): 105. CrossRef

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