Intestinal Research

Fecal Biomarkers in Inflammatory Bowel Disease: Kang-Moon Lee; Intest Res 2013;11(2):73-78. Published online April 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.2.73

Inflammatory bowel diseases (IBD) are idiopathic, remitting and relapsing diseases causing chronic inflammation of intestine. Initial diagnosis, assessment of disease activity, and prediction of treatment outcomes present challenges to physicians in clinical care of IBD. Therefore it is critical to accurately determine inflammatory activity of the gut. Endoscopy, the current gold standard for assessing and monitoring intestinal inflammation, is costly, invasive and at times, dangerous. Fecal biomarkers are a simple, reliable, non-invasive test that, because of their direct contact with the intestinal mucosa, may be more accurate in determining intestinal inflammation than serum biomarkers. Since calprotectin was identified as a marker for IBD, several additional fecal markers, including lactoferrin, S100A12, and M2-pyruvate kinase, have been evaluated for their ability to differentiate and monitor disease activity. Fecal biomarkers are useful in differentiating IBD from functional bowel disorders, monitoring response to treatment and predicting clinical and endoscopic relapse. Although they may not ever replace endoscopy, fecal markers could minimize unnecessary, potentially dangerous examinations and help guide IBD management in a more cost-effective manner. (Intest Res 2013;11:73-78)

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Alteration of stool pH and its association with biomarkers of gut enteropathy among slum-dwelling women of reproductive age in Bangladesh
Ishita Mostafa, S. M. Tafsir Hasan, Md. Amran Gazi, Md. Ashraful Alam, Shah Mohammad Fahim, Kazi Nazmus Saqeeb, Tahmeed Ahmed
BMC Women's Health.2023;[Epub] CrossRef
Value of Fecal Calprotectin Measurement During the Initial Period of Therapeutic Anti-Tubercular Trial
Hyeong Ho Jo, Eun Young Kim, Jin Tae Jung, Joong Goo Kwon, Eun Soo Kim, Hyun Seok Lee, Yoo Jin Lee, Kyeong Ok Kim, Byung Ik Jang
Clinical Endoscopy.2022; 55(2): 256. CrossRef
A comparison of diagnostic performance between two quantitative rapid fecal calprotectin assays in detecting active inflammatory bowel disease
Jong-Mi Lee, Joo Hee Jang, Ji Hyeong Ryu, Jaeeun Yoo, Bo-In Lee, Seung-Jun Kim, Eun-Jee Oh, Hsu-Heng Yen
PLOS ONE.2021; 16(8): e0255974. CrossRef
Diagnostic accuracy of faecal calprotectin in a symptom-based algorithm for early diagnosis of inflammatory bowel disease adjusting for differential verification bias using a Bayesian approach
Anna Viola, Andrea Fontana, Alessandra Belvedere, Riccardo Scoglio, Giuseppe Costantino, Aldo Sitibondo, Marco Muscianisi, Santi Inferrera, Lucia Maria Bruno, Angela Alibrandi, Gianluca Trifirò, Walter Fries
Scandinavian Journal of Gastroenterology.2020; 55(10): 1176. CrossRef
Home-based fecal calprotectin test is expected to play an important role in patients with inflammatory bowel diseases
Young-Ho Kim
Intestinal Research.2018; 16(4): 507. CrossRef
Fecal Calprotectin Level Reflects the Severity of Clostridium difficile Infection
Jieun Kim, Heejung Kim, Hyun Ju Oh, Hyung Sun Kim, Youn Jee Hwang, Dongeun Yong, Seok Hoon Jeong, Kyungwon Lee
Annals of Laboratory Medicine.2017; 37(1): 53. CrossRef
Disease Phenotype, Activity and Clinical Course Prediction Based on C-Reactive Protein Levels at Diagnosis in Patients with Crohn’s Disease: Results from the CONNECT Study
Jee Hye Kwon, Jong Pil Im, Byong Duk Ye, Jae Hee Cheon, Hyun Joo Jang, Kang Moon Lee, You Sun Kim, Sang Wook Kim, Young Ho Kim, Geun Am Song, Dong Soo Han, Won Ho Kim, Joo Sung Kim
Gut and Liver.2016; 10(4): 595. CrossRef
Accuracy of three different fecal calprotectin tests in the diagnosis of inflammatory bowel disease
Hui Won Jang, Hyun Sook Kim, Soo Jung Park, Sung Pil Hong, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
Intestinal Research.2016; 14(4): 305. CrossRef
Clinical Significance of Fecal Lactoferrin and Multiplex Polymerase Chain Reaction in Patients with Acute Diarrhea
Hae Mi Lee, Seungok Lee, Bo-In Lee, Dong Wook Jekarl, Joo-Yong Song, Hye-Jung Choi, Bong Koo Kang, Eun Joo Im, Joon Sung Kim, Jong In Kim, Byung-Wook Kim, Hwang Choi
Gut and Liver.2015;[Epub] CrossRef
Clinical significance of the glucose breath test in patients with inflammatory bowel disease
Ji Min Lee, Kang‐Moon Lee, Yoon Yung Chung, Yang Woon Lee, Dae Bum Kim, Hea Jung Sung, Woo Chul Chung, Chang‐Nyol Paik
Journal of Gastroenterology and Hepatology.2015; 30(6): 990. CrossRef
The Usefulness of Fecal Calprotectin in Differentiating between Functional and Organic Bowel Diseases: Application in Pediatric Constipation Patients
Sung Noh Hong
The Korean Journal of Gastroenterology.2013; 62(5): 261. CrossRef

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Stem Cells in Inflammatory Bowel Disease: New Potential Therapeutic Target: In Hwan Song, Byung Ik Jang; Intest Res 2013;11(2):79-84. Published online April 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.2.79

Abstract PDF

Understanding of the pathophysiology of inflammatory bowel disease (IBD) is constantly evolving and, recently, a number of biologic agents that selectively target specific molecules or pathways to correct the imbalance of the gut immune system have been developed. Among them, an antibody to tumor necrosis factor (anti-TNF) is the first developed drug which has dramatically improved the management of patients with IBD. However, more than one-third of IBD patients do not respond to medications, and there is the problem of antibody formation. Therefore, enormous efforts have been made into the development of novel anti-cytokines and stem cell injection as an alternative to has been made. However, the efficacy and safety of stem cell treatment are under investigation. Some studies have reported very promising data; however, others have shown conflicting results. In addition, most trials involved a very small number of subjects and did not compare stem cell treatment with anti-TNF. The present paper reviews the function and therapeutic mechanism of stem cells for the treatment of IBD. (Intest Res 2013;11:79-84)

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Long-Term Effects of Bone Marrow-Derived Mesenchymal Stem Cells in Dextran Sulfate Sodium-Induced Murine Chronic Colitis
Hyun Jung Lee, Sun-Hee Oh, Hui Won Jang, Ji-Hee Kwon, Kyoung Jin Lee, Chung Hee Kim, Soo Jung Park, Sung Pil Hong, Jae Hee Cheon, Tae Il Kim, Won Ho Kim
Gut and Liver.2016;[Epub] CrossRef

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Stem Cells in Colorectal Cancer: New Potential Therapeutic Target: Tae Il Kim; Intest Res 2013;11(2):85-91. Published online April 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.2.85

Abstract PDF: Within the crypts of the intestinal mucosa, intestinal epithelium is a permanently renewing tissue, the architecture of which is maintained by the ability of the intestinal stem cells to self-renew and to generate a hierarchy of proliferative and differentiated cells. In the hierarchical structure of intestinal epithelia, the balance between proliferation and cell death is important for homeostasis. This unique structure of intestinal mucosa, crypt axis, is supported by micro-environmental factors, and the disruption of the homeostasis of the crypt axis can develop colorectal neoplasia. Recent evidence suggests that colorectal cancer may arise from mutated colorectal stem or progenitor cells termed colorectal cancer stem cells (CSC) or initiating cells because of their exclusive ability to sustain tumor formation. Colorectal CSC have been identified based on the expression of cell surface markers such as CD133, CD44 and CD166, and these cells have stem/progenitor cell properties, the ability to self-renew, differentiate, and proliferate indefinitely to drive continuous expansion of the malignant cell population. The CSCs, in limited number within the bulk of the tumor, may account for their capability of escaping conventional therapies, thus leading to disease relapse and metastasis. To overcome these malignant features of cancer, the researchers emphasize the importance of better characterizing CSC to target the CSC. (Intest Res 2013;11:85-91)

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Clinical Characteristics and Outcomes of Diverticulitis by Physician's Specialty: Seung Jung Jun, Jae Myung Cha, Joung Il Lee, Kwang Ro Joo, Hyun Phil Shin, Jae Jun Park, Jung Won Jeon, Jun Uk Lim, Yoon Jong Seo, Soo Young Moon, Chi Hoon Lee; Intest Res 2013;11(2):92-99. Published online April 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.2.92

Abstract PDF: Background/Aims
Several factors affecting the severity and outcomes of diverticulitis have been reported, but there is little research on physician specialty related with this disease. Therefore, we evaluated the clinical characteristics and outcomes of diverticulitis depending on physician's specialty. Methods: Medical records of 239 patients, who had been hospitalized with first-diagnosed acute colonic diverticulitis at Kyung Hee University Hospital in Gang Dong (Seoul, Korea) from June 2006 to December 2012, were retrospectively analyzed. The patients were classified according to whether they had been managed by gastroenterologists or not. Clinical characteristics and treatment outcomes were compared between two groups. Results: Of these 239 patients, 38 (15.9%) patients were treated by a gastroenterologist and 201 (84.1%) patients by a non-gastroenterologist. Clinical characteristics such as age, gender, body mass index, comorbidity, medication, laboratory results, recurrence and complication were not significantly different between two groups. However, right-sided diverticulitis predominated in the non-gastroenterologist group (79% vs. 91%, P=0.028). From the sub-group analysis of uncomplicated diverticulitis, intravenous antibiotics was used for a shorter period of time by gastroenterologists than non-gastroenterologists (3.3±1.9 days vs. 4.4±2.8 days, P=0.032). Multivariate logistic regression analysis showed that the 3 day administration of intravenous antibiotics significantly depended on the physician's specialty (odds ratio 7.984, 95% confidence interval 1.990-32.043, P=0.003). Conclusions: The results suggest that the duration of intravenous antibiotics for treating uncomplicated colonic diverticulitis was shortened by gastroenterology specialists without increasing operation or recurrence. (Intest Res 2013;11:92-99)

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The Usefulness of a Colonoscopy with Biopsy in the Early and Accurate Diagnosis of Ischemic Colitis: Eui Joong Kim, Soon Man Yoon, Sang Hwa Lee, Ki Bae Kim, Joo Young Lee, Dong-Hwa Lee, Eun Bee Kim, Soonyoung Park, Joung Ho Han, Hee Bok Chae, Seon Mee Park, Sei Jin Youn, Ro Hyun Sung; Intest Res 2013;11(2):100-106. Published online April 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.2.100

Abstract PDF

Background/Aims
Ischemic colitis has a clinical spectrum ranging from mild reversible colitis to an acute fulminant course. Early and accurate diagnosis is therefore mandatory for a good clinical outcome. The aim of this study is to evaluate the efficacy and safety of a colonoscopy and histological examination with biopsy in the early and accurate diagnosis of ischemic colitis. Methods: We investigated the clinical characteristics and endoscopic findings with the histopathology of 89 cases of ischemic colitis from October 2002 to August 2012 in a tertiary-care hospital. All patients underwent a colonoscopy with biopsy within a few days of the onset of symptoms, and the histological features from the biopsy specimens were reviewed. In addition, the occurrence of complications by colonoscopy with biopsy was evaluated. Results: The mean age of the patients was 65.8±12.6 years (male:female, 1:2.2). The major combined disorders were hypertension (51.7%), diabetes (31.5%), and arrhythmia (19.1%). The clinical features usually presented with hematochezia (83.1%), abdominal pain (77.5%), and diarrhea (60.7%). The involved patterns were the left colon (56.2%), right colon (39.3%), and pancolon (4.5%). Based on the main histological features of ischemic colitis, including glandular atrophy (67.4%), hemorrhage (61.8%), capillary thrombi (42.7%), and coagulative necrosis of mucosa (29.2%), 67 of the 89 cases (75.3%) could be confirmed with ischemic colitis. There were no serious complications such as bowel perforation or major bleeding following the colonoscopy with biopsy. Conclusions: A colonoscopy with biopsy is beneficial and safe for the early and precise diagnosis of ischemic colitis. (Intest Res 2013;11:100-106)

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What's the Clinical Features of Colitis in Elderly People in Long-Term Care Facilities?
So Yoon Yoon, Sung-Ae Jung, Sun-Kyung Na, Jae-In Ryu, Hye-Won Yun, Min-Jin Lee, Eun-Mi Song, Seong-Eun Kim, Hye-Kyung Jung, Ki-Nam Shim
Intestinal Research.2015; 13(2): 128. CrossRef
Author's Reply
Eui Joong Kim, Soon Man Yoon
Intestinal Research.2013; 11(3): 231. CrossRef
The Clinical Impact of Early Colonoscopic Biopsy in Ischemic Colitis
Young-Eun Joo
Intestinal Research.2013; 11(3): 229. CrossRef

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Exposure to Diagnostic Radiation in Patients with Inflammatory Bowel Disease: A Single Center Study: Jae Wan Lim, Yoon Suk Jung, Jung Ho Park, Hong Joo Kim, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Dong Il Park; Intest Res 2013;11(2):107-112. Published online April 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.2.107

Abstract PDF: Background/Aims
Western studies recently reported that patients with inflammatory bowel disease (IBD) are exposed to diagnostic radiation at potentially harmful levels. There is little research, however, on exposure to diagnostic radiation in patients with IBD in Asian areas. The present study assessed cumulative radiation exposure dose in patients with IBD who were treated at a single-tertiary medical center in Korea and analyzed the factors that increased the exposure dose. Methods: Retrospective investigation was performed of the medical records of the patients who were followed up for 1 year or more in a period from January 2003 through November 2011 at Kangbuk Samsung Hospital. Results: Included in the study were 202 patients with IBD: 80 (39.6%) had Crohn's disease (CD) and 122 (60.4%) had ulcerative colitis (UC). The mean follow-up period was 4.2±2.5 years for CD and 4.3±1.4 years for UC. The mean culmulative effective dose (CED) for CD and UC were 39.7 and 11.0 mSv respectively (P<0.001). In CD, factors associated with increased CED were surgery, history of intravenous steroid treatment, and structuring or penetrating disease. Conclusions: A substantial proportion of IBD patients, especially CD patients, were exposed to significantly harmful amounts of diagnostic radiation, mainly due to computed tomography examination. Efforts should be made to reduced diagnostic medical radiation, especially in patients at risk for increased radiation exposure. (Intest Res 2013;11:107-112)

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A Clinical Analysis of Gastrointestinal Stromal Tumors in Small Intestine: Comparison of Bleeding and Non-bleeding Group: Sang Jin Lee, Jong Kyu Park, Hyun Il Seo, Koon Hee Han, Young Don Kim, Woo Jin Jeong, Gab Jin Cheon, Jae Seok Song; Intest Res 2013;11(2):113-119. Published online April 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.2.113

Abstract PDF

Background/Aims
Gastrointestinal stromal tumors (GIST) in the small intestine are rare and can cause bleeding. The study investigated the clinical characteristics of GIST in the small intestine and to determine the factors related to gastrointestinal bleeding. Methods: We retrospectively evaluated the clinical outcomes of 22 patients with small bowel GIST who were pathologically diagnosed at Gangneung Asan Hospital between March 1997 and August 2012. Results: The median age was 63.5 (38-82) years. Nine patients (40.9%) had gastrointestinal bleeding, five patients (22.7%) had abdominal pain, two patients (9%) had palpable mass. The site of tumor was the duodenum in nine cases (40.9%), jejunum in 7 cases (31.8%), and ileum in six cases (27.3%). Most patients underwent small bowel resection or wedge resection but three patients underwent pancreaticoduodenectomy. Tumor size ranged from 1.6 to 19 cm (median 6.5 cm). The median mitotic rate was 2 (0-50)/50 high power fields (HPF). The median mitotic rate was 2 (0-50)/50 HPF. Five patients (25%) showed recurrence. Gender, aspirin or warfarin use, size and mitotic index of tumor, hospital stay, recurrence and survival were not significantly different between bleeding and non-bleeding group. Bleeding group showed older age, proximal location in small intestine and mucosal ulceration significantly. Conclusions: Small bowel GISTs with bleeding were marked by older age, mucosal ulceration and location of proximal small bowel (duodenum and jejunum) rather than distal small bowel (ileum). (Intest Res 2013;11:113-119)

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Prognostic Significance of Ki-67 Expression in Patients Undergoing Surgical Resection for Gastrointestinal Stromal Tumor
Seong Yeon Jeong, Won Wo Park, You Sun Kim, Young Il Park, Seung Hyup Kim, Won Jae Yoon, Jeong Seop Moon, Byung Mo Lee, Seong Woo Hong, Yun Kyung Kang
The Korean Journal of Gastroenterology.2014; 64(2): 87. CrossRef

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The Improvement of Nutritional Support with Percutaneous Endoscopic Gastrostomy: Yoon Jong Seo, Jae Myung Cha, Joung Il Lee, Kwang Ro Joo, Hyun Phil Shin, Jae Jun Park, Jung Won Jeon, Jun Uk Lim, Seung Jung Jun, Soo Young Moon, Soo Young Moon, Mi Ran Cho, Jung Sook Lee; Intest Res 2013;11(2):120-126. Published online April 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.2.120

Abstract PDF

Background/Aims
Percutaneous endoscopic gastrostomy (PEG) is the most common method of enteral nutrition for patients who require long term artificial nutrition. PEG has been used as a method of nutritional support; however, improvement of nutritional support via PEG has not yet been reported. In this study, we analyzed the efficacy of nutritional support via PEG. Methods: We conducted a retrospective analysis of 196 consecutive patients who underwent PEG at Kyung Hee University Hospital in Gang Dong from 2006 to 2012. We analyzed clinical characteristics, the method of nutritional support, and the proportion of intake to establish recommendations for nutritional requirements and the duration needed to reach the level of appropriate nutrition. Results: A total of 196 patients included 130 men and 66 women, and their mean age (standard deviation) was 69.1±14.0 years. Compared with caloric and protein supplementation before PEG, 113 kcal (13.8% of baseline) and 4.8 g of protein (17.5% of baseline) could be additionally supplied with PEG (P=0.001, respectively). The number of patients who could take more than 90% of the recommended requirements of caloric and protein supplementation after PEG showed increased caloric and protein intake by 25.4% and 20.2%, respectively, in comparison with those before PEG (P=0.001 and P=0.001, respectively). The mean duration of catch-up for more than 90% of the recommended caloric and protein intake was approximately 11 days. Procedure related complications and early mortality were reported in 8.1% and 0% of patients, respectively. Conclusions: PEG is an effective and safe nutritional support method for patients who require long term artificial nutrition. (Intest Res 2013;11:120-126)

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Reappraisal of Pneumoperitoneum After Percutaneous Endoscopic Gastrostomy
Won Young Park, Tae Hee Lee, Joon Seong Lee, Su Jin Hong, Seong Ran Jeon, Hyun Gun Kim, Joo Young Cho, Jin Oh Kim, Jun Hyung Cho, Sang Wook Lee, Young Kwan Cho
Intestinal Research.2015; 13(4): 313. CrossRef

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Clinical Characteristics of Lower Gastrointestinal Cancer in Crohn's Disease: Case Series of 5 Patients: Ji Min Choi, Changhyun Lee, Yoo Min Han, Minjong Lee, Dong Kee Jang, Jeehye Kwon, Jong Pil Im, Sang Gyun Kim, Joo Sung Kim, Hyun Chae Jung; Intest Res 2013;11(2):127-133. Published online April 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.2.127

Abstract PDF

Crohn's disease is a chronic inflammatory disease that can involve the entire gastrointestinal tract. Several studies indicate that Crohn's patients with long disease duration have an increased risk of small bowel or colorectal cancer. In Korea, only a few cases of Crohn's disease-related small bowel or colorectal cancer have been reported. Here, we described 3 cases of colorectal cancer and 2 cases of small bowel cancer in patients with Crohn's disease. Among 5 patients, 3 had Crohn's disease-related lower gastrointestinal malignancy and the other 2 had sporadic lower gastrointestinal malignancies. Since the diagnosis of Crohn's disease-related lower gastrointestinal malignancy tends to be delayed, the development of malignancy should be considered in patients with long duration of Crohn's disease if patients have refractory symptoms despite intensive medical treatment. Surgical consultation should not be delayed. (Intest Res 2013;11:127-133)

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Metastatic Recurrence of Small Bowel Cancer in Crohn's Disease
Ji Min Choi, Changhyun Lee, Jong Pil Im
The Korean Journal of Gastroenterology.2014; 63(4): 258. CrossRef

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A Case of Perforated Gastrointestinal Stromal Tumor in the Jejunum as a Rare Cause of Acute Abdomen: Seong Yeol Kim, Jong Hyeok Kim, Dong Seon Park, Gil Su Jang, Eun Yeong Hong, Jung Sun An, So Yeon Kim, Ho Young Kim, Dong Hoon Kim, Ji Won Park, Il Hyun Baek, Choong Kee Park; Intest Res 2013;11(2):134-136. Published online April 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.2.134

Abstract PDF

Preoperative diagnosis of Gastrointestinal Stromal Tumors (GISTs) in the small intestine is often delayed until complications such as hemorrhage, bowel obstruction or perforation develop. Such GISTs are usually asymptomatic and tumor perforation is an uncommon clinical presentation. In this report, we review the diagnosis, pathology and treatment of a 32-year-old male with a perforated GIST in the jejunum who presented with symptoms of acute abdomen. Abdominal computed tomography (CT) showed a ruptured huge tumor with inhomogeneous density in the small intestine. The patient underwent a complete tumor excision and jejunal segmental resection. A histopathological examination of the tumor confirmed that it was a GIST. Postoperatively, the patient received medical treatment, using oral Imatinib 400 mg daily for 10 months without any signs of disease recurrence. Prognosis is worse in ruptured GISTs and in these cases, complete surgical resection of the tumor must be followed by adjuvant therapy with Imatinib. (Intest Res 2013;11:134-136)

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Prognostic Significance of Ki-67 Expression in Patients Undergoing Surgical Resection for Gastrointestinal Stromal Tumor
Seong Yeon Jeong, Won Wo Park, You Sun Kim, Young Il Park, Seung Hyup Kim, Won Jae Yoon, Jeong Seop Moon, Byung Mo Lee, Seong Woo Hong, Yun Kyung Kang
The Korean Journal of Gastroenterology.2014; 64(2): 87. CrossRef

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Simultaneous Neuroendocrine Carcinoma and Adenocarcinoma of the Colon: Donggeum Shin, Youngsook Park, Soojung Gong, Seonghwan Kim, Yunju Jo, Sangbong Ahn, Joonkil Han, Eunkyung Kim; Intest Res 2013;11(2):137-141. Published online April 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.2.137

Abstract PDF: Neuroendocrine carcinoma of colon is a rare disease entity that is histologically poorly differentiated and immunochemically synaptophysin positive, enabling it to be confirmed by an immunohistochemical stain. Neuroendocrine carcinomas, in almost all cases, have poor prognosis due to a tendency of early metastasis and lack of standardized treatment. The concurrent diagnosis of neuroendocrine carcinoma and adenocarcinoma is extremely rare. The relation of these two disease entities is not understood. We experienced a patient with a colonic neuroendocrine carcinoma concurrent with adenocarcinoma. A 65-year-old male presented with abdominal pain. Emergent computed tomography suggested a malignant tumor of the ascending colon. Colonoscopy showed an infiltrative lesion in the ascending colon with a luminal narrowing, a large pedunculated lesion at the splenic flexure, and multiple small polyps in the descending colon. The patient underwent a right hemicolectomy including the pedunculated lesion. The pathology confirmed advanced neuroendocrine carcinoma in the ascending colon, adenocarcinoma in proximal descending colon, and multiple metastatic lymph nodes of neuroendocrine carcinomas on abdomen. The patient underwent the postoperative chemotherapy but did not tolerate it well and expired a year after diagnosis. We report this rare case with a review of the literature. (Intest Res 2013;11:137-141)

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A Case of Duodenal Obstruction Due to Intestinal Malrotation Diagnosed in Middle-aged Man: Jae Woo Park, Mun Chul Kim, Min A Yang, Hyun Ju Yoon, Cheon Beom Lee, Wang Guk Oh, Jin Woong Cho; Intest Res 2013;11(2):142-145. Published online April 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.2.142

Abstract PDF: Intestinal malrotation occurs because of an arrest of normal rotation of the embryonic gut. It is often diagnosed in first month of life because of acute complications and requires surgical management. If it is not detected at a young age, it is diagnosed incidentally in advanced age. It is very rarely reported at advanced age with symptoms. In Korea in the last 30 years only about 10 such cases have been reported. In 2010, intestinal malrotation was reported at advanced age in only one case who had acute duodenal obstruction due to non-rotation of the pre-arterial segment of mid-gut. Therefore, we report a case of a 45-year-old man with non-rotation of pre-arterial segment with duodenal obstruction who had complained chronic and mild epigastric discomfort from a year ago. (Intest Res 2013;11:142-145)

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A Case of Acute Colonic Diverticulitis as a Complication of Colonoscopy: Dong Seon Park, Ji Won Park, Seong Yeol Kim, Gil Su Jang, Eun Yeong Hong, Jung Sun An, So Yeon Kim, Il Hyun Baek, Jong Hyeok Kim, Choong Kee Park; Intest Res 2013;11(2):146-148. Published online April 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.2.146

Abstract PDF

Colonoscopy is a good diagnostic tool and facilitates treatment of various colonic diseases. Nevertheless, it can induce many serious complications such as perforation and hemorrhage. Diverticulitis has also been reported as a serious complication of colonoscopy, with an incidence ranging from 0.04% to 0.08%. A 44-year-old male with chronic hepatitis B was presented with general weakness, myalgia, and febrile sensation. After admission for evaluation, pneumonia detected in the left upper and lower lobe and treated. We performed colonoscopy for screening and found multiple colonic diverticula in the right side of the colon. After 48 hours, the patient complained of abdominal pain and febrile sensation. Physical examination revealed tenderness in the right side of the abdomen. Abdomen-pelvis computed tomography showed bowel wall thickening of the cecum and ascending colon and multiple inflamed diverticula at the cecum with pericolic fat infiltration and fluid collection. We diagnosed the patient with acute diverticulitis after colonoscopy. Thereafter, he was treated with bowel rest and broad-spectrum intravenous antibiotics, and recovered. With a review of the relevant literature, we report a case of acute colonic diverticulitis as a complication of colonoscopy. (Intest Res 2013;11:146-148)

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Mahmoud E. Essam, Iosif Beintaris, Matthew D. Rutter
ACG Case Reports Journal.2024; 11(5): e01362. CrossRef
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Zi Qin Ng, Jih Huei Tan, Henry Chor Lip Tan, Mary Theophilus
World Journal of Gastrointestinal Endoscopy.2021; 13(3): 82. CrossRef
Diverticular Bleeding: A Clinical Image
Christopher F Brewer, Yayha Al Abed
Cureus.2021;[Epub] CrossRef
Colonoscopy-Induced Acute Diverticulitis
Se Ryeong Park, Young Seok Bae, Jong Ik Park, Jun Sik Min, Yong Kim
Journal of the Korean Geriatrics Society.2016; 20(2): 108. CrossRef

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New Treatment Option for Recurrent Clostridium difficile Infection: Chang Mo Moon; Intest Res 2013;11(2):149-150. Published online April 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.2.149

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