Intestinal Research

Introduction of Molecular Imaging in Gastrointestinal Endoscopy: Towards a New Horizon: Jae Jun Park; Intest Res 2013;11(4):233-235. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.233

Abstract PDF: Near-infrared Fluorescence Imaging Using a Protease-activatable Nanoprobe in Tumor Detection: Comparison with Narrow-band Imaging (Intest Res 2013;11:268-275)

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Dose Aspirin Inhibit the Expression of Nuclear β-Catenin In Vivo As It Does In Vitro Studies?: Dong-Hoon Yang; Intest Res 2013;11(4):236-237. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.236

Abstract PDF: Effect of Aspirin on Nuclear β-Catenin Expression in Sporadic Colorectal Adenomas (Intest Res 2013;11:283-291)

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Hospital Malnutrition: Dong Kyung Chang; Intest Res 2013;11(4):238-242. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.238

According to worldwide studies, the prevalence of malnutrition among hospitalized patients has been reported to be about 15% to 60%. Hospital malnutrition is related to a high incidence of morbidity and mortality. It is often associated with impaired immunity, a high risk of infectious complications, delayed wound healing after surgery. Complications caused by hospital malnutrition consequently increase the length of hospital stay and total medical costs. It also affects the cost of rehabilitation and other individual and social health care costs. The prevalence of hospital malnutrition has encouraged nutritional support teams to become an integral part of the health care system to improve patient outcome. Collaboration between doctors, dieticians, pharmacists, and nurses specialized in nutrition are therefore vital to this initiative. (Intest Res 2013;11:238-242)

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Nutritional Status of Intensive Care Unit Patients According to the Referral to the Nutrition Support Team and Compliance with the Recommendations
Yunjin Sohn, Taisun Hyun
Korean Journal of Community Nutrition.2022; 27(2): 121. CrossRef
Nutritional Screening and Assessment in Hospitalized Patients
Seong-Eun Kim
The Korean Journal of Gastroenterology.2015; 65(6): 336. CrossRef
Understanding Nutritional Support in Digestive Diseases
Dong Kyung Chang, Geun Am Song
The Korean Journal of Gastroenterology.2015; 65(6): 333. CrossRef
Enteral Nutritional Support in Gastrointestinal and Liver Diseases
Eun Ran Kim
The Korean Journal of Gastroenterology.2015; 65(6): 354. CrossRef

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Nutritional Support in Patients with Inflammatory Bowel Diseases: So Yoon Yoon, Sung-Ae Jung; Intest Res 2013;11(4):243-249. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.243

Abstract PDF

Various dietary and nutritional factors have been suggested as significant etiological factors for both Crohn's disease and ulcerative colitis. However, there are no proven dietary approaches to reduce the risk of development of inflammatory bowel disease. More importantly, nutrition itself has proven to be a central component in the treatment of the disease, both as a primary therapy and for correcting various nutritional deficiencies. Therefore regular evaluation of nutritional status, including specific deficits, is important for the management of patients with inflammatory bowel disease. Nutritional support is effective in inducing clinical remission of Crohn's disease, maintaining the remission, and providing positive benefits to growth and overall nutritional status with minimal adverse effects. This article reviews current evidence of the efficacy of nutritional support in the treatment of inflammatory bowel disease. (Intest Res 2013;11:243-249)

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Alleviation of Intestinal Inflammation by Oral Supplementation of Unripe Apple Ethanolic Extract in Mice
Ha Na Jang, Ui-Jin Bae, Mi Jang, Sung Hyen Lee, Gi-Chang Kim
Journal of the Korean Society of Food Science and Nutrition.2023; 52(3): 231. CrossRef
Risk Factors for Vitamin D, Zinc, and Selenium Deficiencies in Korean Patients with Inflammatory Bowel Disease
Yoo Min Han, Hyuk Yoon, Soo Lim, Mi-Kyung Sung, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Joo Sung Kim
Gut and Liver.2017; 11(3): 363. CrossRef
Parenteral Nutritional Support in Gastrointestinal and Liver Diseases
Byong Duk Ye
The Korean Journal of Gastroenterology.2015; 65(6): 346. CrossRef
Nutritional Screening and Assessment in Hospitalized Patients
Seong-Eun Kim
The Korean Journal of Gastroenterology.2015; 65(6): 336. CrossRef
Enteral Nutritional Support in Gastrointestinal and Liver Diseases
Eun Ran Kim
The Korean Journal of Gastroenterology.2015; 65(6): 354. CrossRef

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Epidemiology of Ulcerative Colitis in South Asia: Amarender Singh Puri; Intest Res 2013;11(4):250-255. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.250

Abstract PDF

The South Asian region comprising of India, Pakistan, Bangladesh, Nepal, and Sri Lanka is multi-ethnic with vast cultural differences. Yet they have in common, a strong predisposition for inflammatory bowel disease especially ulcerative colitis (UC). The vast majority of the population is rural with limited access to health care facilities. Community based studies on epidemiology of UC are sparse making it difficult to extrapolate data for the whole region. India has the highest incidence and prevalence of UC in Asia which is higher than the published figures for Korea and Japan, the two leading industrialized countries in Asia. Asian diaspora studies have revealed an unmasking of the disease when natives of this region migrate to countries with a higher prevalence of the disease. Data mainly from the UK suggests a higher incidence of the disease in Asian migrants compared to the indigenous population. Incidence data from within the sub-continent suggests a higher incidence of the disease in India as compared to its southern neighbour Sri Lanka suggesting a north-south gradient. Time trend studies from India do not suggest an increasing incidence of disease as has been observed in other parts of Asia. Some data point to phenotypically different disease in south Asian patients as compared to Caucasians. Familial clustering and cumulative colectomy rates are higher in Western patients as compared to their Asian counterparts. Asian patients with UC have a significantly lower risk of development of colorectal carcinoma vis a vis the Caucasian population. There is a pressing need for more studies on the epidemiology, long-term outcome and natural history of the disease in this region. (Intest Res 2013;11:250-255)

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Short health scale: A valid measure of health-related quality of life in Korean-speaking patients with inflammatory bowel disease
Soo-Kyung Park, Bong Min Ko, Hyeon Jeong Goong, Jeong Yeon Seo, Sang Hyuk Lee, Hae Lim Baek, Moon Sung Lee, Dong Il Park
World Journal of Gastroenterology.2017; 23(19): 3530. CrossRef
Infliximab‐induced tuberculosis in patients with UC: Experience from India—a country with high prevalence of tuberculosis
Amarender S Puri, Devendra Desai, Ajit Sood, Sanjeev Sachdeva
Journal of Gastroenterology and Hepatology.2017; 32(6): 1191. CrossRef
Adsorptive Granulocyte and Monocyte Apheresis in the Treatment of Ulcerative Colitis: The First Multicenter Study in China
Ya-Min Lai, Wei-Yan Yao, Yao He, Xuan Jiang, Yu-Bei Gu, Min-Hu Chen, Yu-Lan Liu, Yao-Zong Yuan, Jia-Ming Qian
Gut and Liver.2017; 11(2): 216. CrossRef
Extent of disease is a major outcome predictor in patients with ulcerative colitis and pregnancy
Amarender Puri, Vaishali Bharadwaj, Sanjeev Sachdeva
Indian Journal of Gastroenterology.2015; 34(2): 108. CrossRef
Colon Cancer Screening and Surveillance in Inflammatory Bowel Disease
Song I Bae, You Sun Kim
Clinical Endoscopy.2014; 47(6): 509. CrossRef

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Biological Therapy for the Prevention and Treatment of Postoperative Endoscopic Recurrence in Crohn's Disease: Time for Acceptance?: Paulo Gustavo Kotze, Rogério Saad-Hossne; Intest Res 2013;11(4):256-260. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.256

Abstract PDF

In most patients, postoperative endoscopic recurrence (PER) occurs 1 year after abdominal resection for Crohn's disease (CD). Preventing PER is essential for disease control, as most patients develop further clinical and surgical recurrences. Conventional therapy with nitroimidazoles, aminosalicylates, and immunomodulators have limited efficacy for preventing PER. Initial trials with biological therapy (infliximab and adalimumab) showed promising results in preventing PER, and the efficacy of these drugs seems higher than that with conventional therapy. The aim of this review is to outline the results of studies that used infliximab or adalimumab for preventing and treating PER in CD patients. Data with both agents are available, and a few, small prospective trials have shown the efficacy of these drugs in patients with a high risk for recurrence. We believe that, in 2013, biological agents will be better accepted for the prevention PER in CD patients, in addition to the already existing data. Larger trials are still underway, and their results will certainly determine the role of these agents in PER, which develops after bowel resection for CD. (Intest Res 2013;11:256-260)

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Efficacy and safety of biosimilar infliximab in bio-naïve patients with Crohn’s disease
Tsubasa Oike, Naoki Akizue, Yuki Ohta, Hirotaka Koseki, Masaya Saito, Yuya Yokoyama, Yushi Imai, Takashi Taida, Kenichiro Okimoto, Keiko Saito, Sadahisa Ogasawara, Tomoaki Matsumura, Tomoo Nakagawa, Makoto Arai, Tatsuro Katsuno, Yoshihiro Fukuda, Yoshio K
Arab Journal of Gastroenterology.2024; 25(3): 257. CrossRef
Gastric lesions in patients with Crohn's disease in Korea: a multicenter study
Hoonsub So, Byong Duk Ye, Young Soo Park, Jihun Kim, Joo Sung Kim, Won Moon, Kang-Moon Lee, You Sun Kim, Bora Keum, Seong-Eun Kim, Kyeong Ok Kim, Eun Soo Kim, Chang Kyun Lee, Sung Pil Hong, Jong Pil Im, Ja Seol Koo, Chang Hwan Choi, Jeong Eun Shin, Bo In
Intestinal Research.2016; 14(1): 60. CrossRef
Efficacy and safety of CT‐P13, a biosimilar of infliximab, in patients with inflammatory bowel disease: A retrospective multicenter study
Yoon Suk Jung, Dong Il Park, Young Ho Kim, Ji Hyun Lee, Pyoung Ju Seo, Jae Hee Cheon, Hyoun Woo Kang, Ji Won Kim
Journal of Gastroenterology and Hepatology.2015; 30(12): 1705. CrossRef
Conventional Versus Biological Therapy for Prevention of Postoperative Endoscopic Recurrence in Patients With Crohn's Disease: an International, Multicenter, and Observational Study
Paulo Gustavo Kotze, Antonino Spinelli, Rodolff Nunes da Silva, Ivan Folchini de Barcelos, Fábio Vieira Teixeira, Rogério Saad-Hossne, Idblan Carvalho de Albuquerque, Marcia Olandoski, Lorete Maria da Silva Kotze, Yasuo Suzuki, Akihiro Yamada, Ken Takeuch
Intestinal Research.2015; 13(3): 259. CrossRef
Post-marketing study of biosimilar infliximab (CT-P13) to evaluate its safety and efficacy in Korea
Sang Hyoung Park, Young-Ho Kim, Ji Hyun Lee, Hyeok Jin Kwon, Suck-Ho Lee, Dong Il Park, Hyung Kil Kim, Jae Hee Cheon, Jong Pil Im, You Sun Kim, Sung Young Lee, Sang Joon Lee
Expert Review of Gastroenterology & Hepatology.2015; 9(sup1): 35. CrossRef
What is the Important Issue to Prevent the Postoperative Crohn's Disease?
You Sun Kim
Intestinal Research.2014; 12(2): 85. CrossRef
Author's Reply
Kang-Moon Lee
Intestinal Research.2014; 12(3): 260. CrossRef

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Epigallocatechin-3-gallate Inhibits the Expression of Adhesion Molecules by Blocking Nuclear Factor Kappa B Signaling in Intestinal Epithelial Cells: Dae-Seong Myung, Young-Lan Park, So-Young Joo, Eun Myung, Cho-Yun Chung, Hyung-Chul Park, Jong-Sun Kim, Sung-Bum Cho, Wan-Sik Lee, Hyun-Soo Kim, Young-Eun Joo; Intest Res 2013;11(4):261-267. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.261

Abstract PDF

Background/Aims
Epigallocatechin-3-gallate (EGCG) is the main polyphenol in green tea and has anti-inflammatory and anti-oxidative effects. The aim of this study was to determine the impact of EGCG on the expression of adhesion molecules and lipopolysaccharide (LPS)-induced nuclear factor-kappa B (NF-ՊB) signaling in rat intestinal epithelial (RIE) cells. Methods: The effect of EGCG on LPS-induced NF-ՊB signaling and expression of intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 was examined by reverse transcription polymerase chain reaction, western blotting, immunofluorescence and electrophoretic mobility shift assay. Results: LPS-induced expression of ICAM-1 and VCAM-1 mRNA was inhibited by EGCG treatment in RIE cells. LPS-induced inhibitor of kappa B alpha degradation and NF-ՊB nuclear translocation were blocked by EGCG in RIE cells. EGCG blocked LPS-induced NF-ՊB DNA-binding activity in RIE cells. The pharmacological NF-ՊB inhibitor Bay11-7082 suppressed the LPS-induced expression of ICAM-1 and VCAM-1 mRNA in RIE cells. Conclusions: These results indicate that EGCG inhibits LPS-induced ICAM-1 and VCAM-1 expression by blocking NF-ՊB signaling in intestinal epithelial cells. (Intest Res 2013;11:261-267)

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Polyphenols and inflammatory bowel disease: Natural products with therapeutic effects?
Mostafa Vaghari-Tabari, Forough Alemi, Maryam Zokaei, Soheila Moein, Durdi Qujeq, Bahman Yousefi, Payam Farzami, Seyed Soheil Hosseininasab
Critical Reviews in Food Science and Nutrition.2024; 64(13): 4155. CrossRef
Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NF-κB Signaling Pathway
Caiyun Yu, Dong Wang, Zaibin Yang, Tian Wang
International Journal of Molecular Sciences.2022; 23(13): 6939. CrossRef
Tieguanyin extracts ameliorated DSS-induced mouse colitis by suppressing inflammation and regulating intestinal microbiota
Yuxi Zhang, Xinyu Feng, Haiyu Lin, Xue Chen, Puming He, Yuefei Wang, Qiang Chu
Food & Function.2022; 13(24): 13040. CrossRef
Anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium-induced colitis model
Seung Kak Shin, Jae Hee Cho, Eui Joo Kim, Eun-Kyung Kim, Dong Kyun Park, Kwang An Kwon, Jun-Won Chung, Kyoung Oh Kim, Yoon Jae Kim
World Journal of Gastroenterology.2017; 23(25): 4559. CrossRef

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Near-infrared Fluorescence Imaging Using a Protease-activatable Nanoprobe in Tumor Detection: Comparison with Narrow-band Imaging: Soon Man Yoon, In-Wha Kim, Miyeoun Song, Eun-Ju Do, Ju Hee Ryu, Kwangmeyung Kim, Ick Chan Kwon, Mi Jung Kim, Dae Hyuk Moon, Dong-Hoon Yang, Kyoung Jo Kim, Byong Duk Ye, Jeong-Sik Byeon, Suk-Kyun Yang, Jin-Ho Kim, Seung-Jae Myung; Intest Res 2013;11(4):268-275. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.268

Abstract PDF

Background/Aims
Advances in endoscopic technology seek to improve the accuracy of neoplastic tumor detection. Recently developed endoscopy devices such as narrow-band imaging (NBI) nevertheless have limitations in morphologic diagnosis. The purpose of this study was to investigate whether a novel imaging technique—near-infrared fluorescence (NIRF) imaging using a protease-activatable nanoprobe—could provide more accurate neoplastic tumor detection, compared to NBI. Methods: Images of the intestines of ApcMin/+ mice were obtained by NIRF using a matrix metalloproteinase (MMP)-sensing probe, which was based on a nanoparticle platform. Immediately after imaging, endoscopy with NBI capability was performed on the same excised intestine. Macroscopic and microscopic findings in the intestines were assessed, and MMP expression was analyzed by Western blotting and real-time polymerase chain reaction. Results: Numerous tiny polypoid lesions were present in the intestines of aged ApcMin/+ mice. These lesions included adenomas, lymphoid follicles, and protruding normal tissues. When using NIRF imaging with an MMP-activatable nanoprobe, adenomatous polyps showed higher fluorescence, compared to lymphoid follicles or adjacent normal tissues. The expression of MMP was higher in the adenomatous tissue than in the other tissues. The sensitivity and specificity for adenoma detection were 88.9% and 82.2%, respectively, when using NIRF imaging with a MMP-nanoprobe, compared to 77.8% and 66.7%, respectively, when using NBI (P<0.05). Conclusions: Near-infrared fluorescence imaging with a protease-activatable nanoprobe could aid in the differentiation of tumor characteristics. Clinical application of this approach may improve the endoscopic detection of neoplastic tumors. (Intest Res 2013;11:268-275)

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Feasibility of moxifloxacin and proflavine dual fluorescence imaging for detecting gastrointestinal neoplastic lesions: A prospective study
Kwangwoo Nam, Noseong Park, Seunghun Lee, Suil Jeon, Jungbin Lee, Seung‐Mo Hong, Sung Wook Hwang, Sang Hyoung Park, Dong‐Hoon Yang, Byong Duk Ye, Jeong‐Sik Byeon, Suk‐Kyun Yang, Jeong Hoon Lee, Do Hoon Kim, Ki Hean Kim, Seung‐Jae Myung
Lasers in Surgery and Medicine.2023; 55(4): 378. CrossRef
Molecular Imaging of Colorectal Tumors by Targeting Colon Cancer Secreted Protein-2 (CCSP-2)
Jaeil Kim, Eun-ju Do, Helen Moinova, Sang Mun Bae, Ja Young Kang, Seung-Mo Hong, Stephen P. Fink, Jinmyoung Joo, Young-Ah Suh, Se Jin Jang, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Jaewon Choe, Suk-Kyun Yang, Sanfo
Neoplasia.2017; 19(10): 805. CrossRef
Introduction of Molecular Imaging in Gastrointestinal Endoscopy: Towards a New Horizon
Jae Jun Park
Intestinal Research.2013; 11(4): 233. CrossRef

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Clinical Practice of Surveillance Colonoscopy according to the Classification of Colorectal Intraepithelial Neoplasia in Korea: High-grade Dysplasia/Carcinoma In Situ Versus Intramucosal Carcinoma: Sung Pil Hong, Tae Il Kim, Hyun Gun Kim, Hyun-Soo Kim, Seong-Eun Kim, Kyu Chan Huh, Jeong Eun Shin, Jae Myung Cha, Suck-Ho Lee, Intestinal Tumor Research Group, Korean Association for the Study of the Intestinal Disease; Intest Res 2013;11(4):276-282. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.276

Abstract PDF

Background/Aims
Recent guidelines strongly recommend that the interval of surveillance colonoscopy be determined according to the risk stratification obtained at index colonoscopy. However, because of the differences in perception of the classification of colorectal intraepithelial neoplasia between Asian and Western countries, there is some confusion about surveillance colonoscopy. The aim of the present study was to evaluate the clinicopathological characteristics and the interval of surveillance colonoscopy between patients with high-grade dysplasia/carcinoma in situ and those with intramucosal carcinoma. Methods: From January 2003 to June 2010, 727 patients were included from 8 tertiary centers. Four hundred fifteen patients (57.1%) had high-grade dysplasia /carcinoma in situ (group A), and 312 (43.9%) had intramucosal carcinoma (group B). Clinicopathological data were reviewed retrospectively. Results: Group A had a significantly more frequent family history of colorectal cancer (3.1% vs. 0.6%, P<0.001), smaller polyp size (12 mm vs. 15 mm, P=0.001), and more proximal location (31.1% vs. 21.8%, P=0.005) than did group B. Among 727 patients, surveillance colonoscopy was performed within 6 months in 55.8% of patients and within 12 months in 77.8%. Group B had a significantly shorter interval of surveillance colonoscopy than did group A (P<0.001). There was no difference in detection of advanced neoplasia at surveillance colonoscopy between the 2 groups (6.6% vs. 5.4%, P=0.638). Conclusions: The recommended interval of surveillance colonoscopy is not followed in Korea. More education about post-polypectomy surveillance guidelines is required. (Intest Res 2013;11:276-282)

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Risk of developing advanced colorectal neoplasia after removing high‐risk adenoma detected at index colonoscopy in young patients: A KASID study
Soo‐Kyung Park, Nam Hee Kim, Yoon Suk Jung, Won Hee Kim, Chang Soo Eun, Bong Min Ko, Geom Seog Seo, Jae Myung Cha, Jae Jun Park, Kyeong Ok Kim, Chang Mo Moon, Yoonho Jung, Eun Soo Kim, Seong Ran Jeon, Chang Kyun Lee, Dong Il Park
Journal of Gastroenterology and Hepatology.2016; 31(1): 138. CrossRef
The Risk of Metachronous Advanced Colorectal Neoplasia Rises in Parallel with an Increasing Number of High-Risk Findings at Baseline
Seung Min Lee, Jeong Hwan Kim, In Kyung Sung, Sung Noh Hong
Gut and Liver.2015; 9(6): 741. CrossRef
Colonic Chicken Skin Mucosa is an Independent Endoscopic Predictor of Advanced Colorectal Adenoma
Eun Ju Chung, Ji Young Lee, Jaewon Choe, Hye-Sook Chang, Jongcheol Kim, Dong Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Kyung-Jo Kim, Suk-Kyun Yang, Jin-Ho Kim, Seung-Jae Myung
Intestinal Research.2015; 13(4): 318. CrossRef
Surveillance Colonoscopy after Polypectomy: Actual Practice in Korea
Kyeong Ok Kim
Intestinal Research.2014; 12(1): 83. CrossRef

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Effect of Aspirin on Nuclear β-Catenin Expression in Sporadic Colorectal Adenomas: Hee Jung Kim, Sung Joon Lee, Sung Chul Park, Dae Hee Choi, Chang Don Kang, Gu Kang; Intest Res 2013;11(4):283-291. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.283

Abstract PDF

Background/Aims
In addition to the inhibition of cyclooxygenase-2, the chemopreventive effect of non-steroidal anti-inflammatory drugs on the nuclear translocation of β-catenin has been suggested in patients with familial adenoma polyposis. We investigated the effect of aspirin on the β-catenin signaling pathway in patients with sporadic colorectal adenoma. Methods: We selected patients diagnosed with colorectal adenoma. Patients who had been taking aspirin for more than 12 months were identified as the aspirin group, and those who did not were the non-aspirin group. Their characteristics, including size and degree of dysplasia, were compared. Immunohistochemical staining was conducted and the expression levels of nuclear β-catenin and cyclin D1 were investigated. Results: The median duration of aspirin intake was 37 months; there were no significant differences in the size, histological type, and degree of dysplasia between the two groups. Nuclear β-catenin expression was observed in 43.2% of the patients in the aspirin group and in 18.9% of those in the non-aspirin group (P < 0.05). There was no significant difference in nuclear cyclin D1 staining between the aspirin (78.4%) and non-aspirin (91.9%) groups. Conclusions: In this retrospective study, nuclear β-catenin expression in sporadic colorectal adenoma in the aspirin group was not inhibited compared with that in the non-aspirin group. Therefore, further prospective studies with a large number of patients are necessary. (Intest Res 2013;11:283-291)

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Dose Aspirin Inhibit the Expression of Nuclear β-CateninIn VivoAs It DoesIn VitroStudies?
Dong-Hoon Yang
Intestinal Research.2013; 11(4): 236. CrossRef

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The Impact of Radiation Exposure on the Prevalence of Functional Dyspepsia and Irritable Bowel Syndrome in Hospital Radiation Workers: Ju Young Choi, Sung-Ae Jung, Hye Won Kang, Hye-Won Yun, Jae-In Ryu, Seong-Eun Kim, Hye-Kyung Jung, Ki-Nam Shim, Kwon Yoo; Intest Res 2013;11(4):292-298. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.292

Abstract PDF

Background/Aims
Health care workers inevitably encounter many physical hazards including ionizing radiation, and have increased levels of psychological disturbance. This study was designed to investigate the prevalence of functional gastrointestinal disorders among hospital radiation workers and to determine significant factors associated with these results. Methods: Whole body radiation doses of radiation workers were evaluated using the electronic dosimeter. The prevalence of functional dyspepsia (FD) and irritable bowel syndrome (IBS) were assessed by the bowel symptom questionnaire. The subjects were classified according to radiation dose, sleep quality, and psychological stress level, and the prevalence of FD and IBS was comparatively analyzed. Results: A total of 70 subjects were recruited. The prevalence of FD and IBS was 31.4% and 22.9%, respectively. The average radiation dose per exposed worker for 1 year was 0.56±0.92 mSv. By multivariate logistic regression analysis, a significant factor associated with the prevalence of FD was their high level of stress (odds ratio, 6.37; 95% confidence interval, 1.38-29.53). Between radiation workers with IBS and those without IBS, there was no significant difference in radiation exposure level, sleep quality, and stress level. There was no difference in the prevalence of IBS (40.0% vs. 15.8%, P=0.09) and FD (30.0% vs. 31.6%, P=0.92) between the relatively high-dose (total dose accumulated during the 3 years ≥9.4 mSv) and low-dose exposed group (<9.4 mSv). Conclusions: Occupational exposure to low levels of radiation does not seem to be significantly related to IBS and FD, but high stress level seems to be related to FD. (Intest Res 2013;11:292-298)

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Radiation Exposure and Functional Gastrointestinal Disease
Hyun Il Seo
Intestinal Research.2014; 12(4): 335. CrossRef

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Crohn's Disease Complicated with Duodenocolic Fistula: A Case Report: Meng-Tzu Weng, Shu-Chen Wei, Yu-Wen Tien, I-Lun Shih, Jau-Min Wong; Intest Res 2013;11(4):299-302. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.299

Abstract PDF

Fistula formation is common during the course of Crohn's disease, whereas duodenocolic fistulas are very rare. The management of internal fistulas in Crohn's disease is a complex issue. Herein, we report a case of duodenocolic fistula manifested by increasing frequency of diarrhea and loss of body weight. The fistula was diagnosed by upper gastrointestinal tract barium series, magnetic resonance enterography, and panendoscopy and was treated with a right hemicolectomy and Whipple procedure because of the simultaneous occurrence of pancreatic head tumor. Subsequent treatment with adalimumab, azathioprine, and mesalazine was prescribed for the maintenance of disease remission, and the patient was well until 18 months after the surgery. (Intest Res 2013;11:299-302)

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Transverse Colonic Stricture Along with Colo-Duodenal Fistula—a Rare and Interesting Finding in Crohn’s Disease
Vivek Agrawal, Raghav Nayar, Md Faizul Haque
Indian Journal of Surgery.2018; 80(5): 527. CrossRef

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Necrotizing Myositis as an Extraintestinal Manifestation of Crohn's Disease: Dong Hyun Kim, Kyu Hyun Paik, Hee Jun Shim, Su Yeon Rhie, Lae Ik Jung, Beom Jin Kim, Jae Gyu Kim; Intest Res 2013;11(4):303-305. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.303

Abstract PDF

Inflammatory bowel disease is associated with extraintestinal manifestations involving almost every organ system in the body. Crohn's disease (CD) appears to be more commonly associated with an inflammatory myopathy than ulcerative colitis. However, myopathy of the thigh in patients with CD is rare. We report an unusual site of necrotizing myositis in a patient with CD. A 23-year-old woman presented with swelling and pain at the left popliteal area that had lasted for 1 week. Twenty-two months before admission, she had presented with pyoderma gangrenosum on the left upper chest and was diagnosed with CD. A magnetic resonance imaging scan of her leg revealed diffuse swelling in the left semimembranous muscle and biceps femoris muscle that was compatible with myositis, and a cystic lesion in the distal portion of the semimembranous muscle. The findings from semimembranous muscle biopsy were also consistent with necrotizing myositis. In conclusion, myositis, although rare, can be an extraintestinal manifestation of CD. (Intest Res 2013;11:303-305)

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Prevention and Treatment of Thromboembolism in Patients with Inflammatory Bowel Disease
Jae Jun Park
The Korean Journal of Gastroenterology.2015; 65(3): 151. CrossRef

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Response to Neoadjuvant Chemoradiotherapy in a Patient with Mucinous Adenocarcinoma Arising from a Chronic Anorectal Fistula and Diagnosed by Transrectal Punch Biopsy: A Case Report: Heejin Park, Dahyun Jung, Sunoch Yoon, Chanhee Kyung, Ikjae Lee, Joohee Kim, Hyojin Park; Intest Res 2013;11(4):306-309. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.306

Abstract PDF: Mucinous adenocarcinoma arising from a chronic anorectal fistula is a rare condition. It is often confused with a hemorrhoid or perineal abscess, which consequently delays accurate diagnosis. Here, we report the case of a 58-year-old man with blood-tinged stool who reported a rectal mass, which was diagnosed as mucinous adenocarcinoma arising from an anal fistula. After initial computed tomography-guided needle aspiration biopsy had failed to provide an accurate diagnosis, transrectal punch biopsy was performed to obtained adequate tissue sample for confirmative histological diagnosis. The patient was successfully treated with neoadjuvant concurrent chemoradiotherapy followed by surgical intervention. (Intest Res 2013;11:306-309)

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A Case of Immune Thrombocytopenic Purpura Associated with Preexisting Ulcerative Colitis Treated with Colectomy and Splenectomy: Jee Hye Kwon, Changhyun Lee, Ji Min Choi, Yoo Min Han, Young Hoon Choi, June Young Lee, Hyuk Yoon, Jaeyoung Chun, Kyu Joo Park, Jong Pil Im, Sang Gyun Kim, Joo Sung Kim, Hyun Chae Jung; Intest Res 2013;11(4):310-316. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.310

Abstract PDF

Ulcerative colitis is a chronic inflammatory bowel disease of unknown etiology, associated with extraintestinal manifestations, including the rarely reported immune thrombocytopenic purpura. Here, we present a case of immune thrombocytopenic purpura associated with preexisting ulcerative colitis. The patient was diagnosed with ulcerative colitis 13 years ago. Two years after diagnosis, he presented with hematochezia and active ulcerative colitis. Despite steroid use, the platelet count gradually decreased to 21,000/mm3. Hematochezia and the platelet count recovered after the administration of cyclosporine, and ulcerative colitis was in near complete remission for 11 years. However, the patient was re-admitted for hematochezia and thrombocytopenia persisting over a month. Medical management including increased doses of steroids in combination with cyclosporin failed to control hematochezia and thrombocytopenia. Immune thrombocytopenic purpura was suspected on the basis of normocellular marrow with a normal number of megakaryocytes. To treat uncontrolled colitis and steroid-refractory thrombocytopenia, total proctocolectomy with ileal pouch-anal anastomosis and splenectomy were performed. The patient was followed up for 10 months after surgery and was found to be in good health with a normal platelet count. Therefore, colectomy alone or in combination with splenectomy should be considered in cases of life-threatening ulcerative colitis complicated with steroid-refractory immune thrombocytopenic purpura. (Intest Res 2013;11:310-316)

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Resolved Hypereosinophilic Syndrome and Immune Thrombocytopenic Purpura in Ulcerative Colitis Patients Post Colectomy: A Case Series and Literature Review
Ahmed Hussein Subki, Manal Ismail Bokhary, Sultan Abdulrahman Alandijani, Mohannad Abdulrahman Aljehani, Ahmed Wasel Alharbi, May Alzahrani, Saud Suliman Almuhammadi, Bassim Tahseen Albeirouti, Mohamed Abdulmajid Abduljabar, Silvio Danese
Journal of Inflammation Research.2022; Volume 15: 6373. CrossRef
A Case of Immune Thrombocytopenic Purpura Accompanying Ulcerative Colitis
Hyun Tae Kim, Tae Oh Kim, Hyung Jun Kim, Soon Il Lee, Gi Jung Jeon, Eun Ji Lee, Seunghyun Park, Taehoon No
The Korean Journal of Gastroenterology.2014; 64(4): 234. CrossRef

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A Case of Cronkhite-Canada Syndrome Showing Spontaneous Remission: Dong-Uk Kang, Dong-Hoon Yang, Yunsik Choi, Ji-Beom Kim, Ho-Su Lee, Hyo Jeong Lee, Sang Hyoung Park, Kee Wook Jung, Kyung-Jo Kim, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Jin-Ho Kim; Intest Res 2013;11(4):317-322. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.317

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Cronkhite-Canada syndrome (CCS) is a rare, noninherited gastrointestinal polyposis syndrome associated with ectodermal changes such as alopecia, nail dystrophy, and cutaneous hyperpigmentation. The etiology and pathogenesis of CCS are not known, but diarrhea, malnutrition, gastrointestinal bleeding, and infection may occur in the affected patient; moreover, this condition could be fatal. However, previous reports have described several cases of spontaneous remission. We report a 60-year-old man who was incidentally found to have colonic polyposis, alopecia, and hypogeusia and was diagnosed to have CCS. However, this patient experienced spontaneous remission, including regrowth of body hair and alleviation of bowel inflammation, without any specific medications such as steroids, antibiotics, or proton pump inhibitors. (Intest Res 2013;11:317-322)

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Cronkhite-Canada Syndrome Showing Good Early Response to Steroid Treatment
Woohee Cho, Kwangwoo Nam, Ki Bae Bang, Hyun Deok Shin, Jeong Eun Shin
The Korean Journal of Gastroenterology.2018; 71(4): 239. CrossRef

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A Rare Complication in a Patient Irradiated for Cervical Cancer: Seong Ran Jeon; Intest Res 2013;11(4):323-324. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.323

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The Efficacy of Vedolizumab, an α4β7 Integrin Antibody, in Crohn's Disease and Ulcerative Colitis: Eun Sun Kim; Intest Res 2013;11(4):325-326. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.325

Abstract PDF: Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis (N Engl J Med 2013;369:699-710) Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease (N Engl J Med 2013;369:711-721)

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The Real State of Colonoscopy Quality of Non-tertiary Hospitals in Korea: Yoon Suk Jung; Intest Res 2013;11(4):327-329. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.327

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Author's Reply: Hyun Gun Kim; Intest Res 2013;11(4):330-331. Published online October 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.4.330

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