Skip Navigation
Skip to contents

Intest Res : Intestinal Research

IMPACT FACTOR

Previous issues

Page Path
HOME > Browse articles > Previous issues
17 Previous issues
Filter
Filter
Article category
Keywords
Authors
Volume 12(2); April 2014
Prev issue Next issue
Editorials
What is the Important Issue to Prevent the Postoperative Crohn's Disease?
You Sun Kim
Intest Res 2014;12(2):85-86.   Published online April 29, 2014
DOI: https://doi.org/10.5217/ir.2014.12.2.85
PDFPubReader

Citations

Citations to this article as recorded by  
  • Monitoring Disease Activity: How and When?
    Kang-Moon Lee
    The Korean Journal of Gastroenterology.2018; 71(2): 69.     CrossRef
  • Impact of inflammatory bowel disease on daily life: an online survey by the Korean Association for the Study of Intestinal Diseases
    Young Sun Kim, Sung-Ae Jung, Kang-Moon Lee, Soo Jung Park, Tae Oh Kim, Chang Hwan Choi, Hyun Gun Kim, Won Moon, Chang Mo Moon, Hye Kyoung Song, Soo-Young Na, Suk-Kyun Yang
    Intestinal Research.2017; 15(3): 338.     CrossRef
  • Author's Reply
    Kang-Moon Lee
    Intestinal Research.2014; 12(3): 260.     CrossRef
  • 3,708 View
  • 27 Download
  • 2 Web of Science
  • 3 Crossref
Close layer
Clinicopathological Characteristics of Newly Diagnosed Colorectal Cancers in Community Gastroenterology Practice
Chang Kyun Lee
Intest Res 2014;12(2):87-89.   Published online April 29, 2014
DOI: https://doi.org/10.5217/ir.2014.12.2.87
PDFPubReader

Citations

Citations to this article as recorded by  
  • Risk factors of missed colorectal lesions after colonoscopy
    Jeonghun Lee, Sung Won Park, You Sun Kim, Kyung Jin Lee, Hyun Sung, Pil Hun Song, Won Jae Yoon, Jeong Seop Moon
    Medicine.2017; 96(27): e7468.     CrossRef
  • Impact of KITENIN on tumor angiogenesis and lymphangiogenesis in colorectal cancer
    HYUNG-HOON OH, KANG-JIN PARK, NURI KIM, SUN-YOUNG PARK, YOUNG-LAN PARK, CHAN-YOUNG OAK, DAE-SEONG MYUNG, SUNG-BUM CHO, WAN-SIK LEE, KYUNG-KEUN KIM, YOUNG-EUN JOO
    Oncology Reports.2016; 35(1): 253.     CrossRef
  • Risk of developing advanced colorectal neoplasia after removing high‐risk adenoma detected at index colonoscopy in young patients: A KASID study
    Soo‐Kyung Park, Nam Hee Kim, Yoon Suk Jung, Won Hee Kim, Chang Soo Eun, Bong Min Ko, Geom Seog Seo, Jae Myung Cha, Jae Jun Park, Kyeong Ok Kim, Chang Mo Moon, Yoonho Jung, Eun Soo Kim, Seong Ran Jeon, Chang Kyun Lee, Dong Il Park
    Journal of Gastroenterology and Hepatology.2016; 31(1): 138.     CrossRef
  • Effect of Recepteur d'Origine Nantais expression on chemosensitivity and tumor cell behavior in colorectal cancer
    NURI KIM, SUNG-BUM CHO, YOUNG-LAN PARK, SUN-YOUNG PARK, EUN MYUNG, SEUNG-HUN KIM, HYUNG-MIN YU, YOUNG-AE SON, DAE-SEONG MYUNG, WAN-SIK LEE, YOUNG-EUN JOO
    Oncology Reports.2016; 35(6): 3331.     CrossRef
  • Filamin A interacting protein 1-like expression inhibits progression in colorectal cancer
    Young-Lan Park, Sun-Young Park, Seung-Hyun Lee, Rul-Bin Kim, Joong-Keun Kim, Sung-Yoon Rew, Dae-Seong Myung, Sung-Bum Cho, Wan-Sik Lee, Hyun-Soo Kim, Young-Eun Joo
    Oncotarget.2016; 7(44): 72229.     CrossRef
  • 3,651 View
  • 17 Download
  • 6 Web of Science
  • 5 Crossref
Close layer
Reviews
Lipopolysaccharide: Basic Biochemistry, Intracellular Signaling, and Physiological Impacts in the Gut
Sang Hoon Rhee
Intest Res 2014;12(2):90-95.   Published online April 29, 2014
DOI: https://doi.org/10.5217/ir.2014.12.2.90
AbstractAbstract PDFPubReader

Lipopolysaccharide (LPS), a main constituent of Gram-negative bacterial membrane, specifically activates Toll-like receptor 4, leading to the production of pleiotropic cytokines/chemokines which in turn regulate inflammatory and innate and subsequent adaptive immune responses. Given that human gut harbors a large collection of commensal bacteria, LPS released by gut microbes is able to make the great impact on gut homeostasis through the intracellular signaling pathways engaged by host-microbial interaction. Emerging evidence indicates that LPS in the gut has a potency to elicit the pathogenesis of intestinal inflammatory diseases such as inflammatory bowel disease and necrotizing enterocolitis. In this review, we discuss the current understanding of the basic biochemistry of LPS, LPS-induced intracellular signaling, and physiological impacts of LPS in the intestine.

Citations

Citations to this article as recorded by  
  • Preclinical evidence using synthetic compounds and natural products indicates that AMPK represents a potential pharmacological target for the therapy of pulmonary diseases
    Chao Yang, Limor Rubin, Xiyong Yu, Philip Lazarovici, Wenhua Zheng
    Medicinal Research Reviews.2024; 44(3): 1326.     CrossRef
  • Deciphering the intricate linkage between the gut microbiota and Alzheimer's disease: Elucidating mechanistic pathways promising therapeutic strategies
    Junyi Liang, Yueyang Wang, Bin Liu, Xiaohong Dong, Wenhui Cai, Ning Zhang, Hong Zhang
    CNS Neuroscience & Therapeutics.2024;[Epub]     CrossRef
  • Isoorientin inhibits NLRP3 inflammasome activation by activating Nrf2 signaling to delay the progression of osteoarthritis
    Yuxin Deng, Xiaoying Zhao, Yu Chen, Chenchao Li, Qingyu Deng, Chenyu Wu, Zongxin Zhu, Xiaolei Zhang, Yifei Zhou, Jingquan Yang
    Journal of Functional Foods.2024; 116: 106187.     CrossRef
  • One‐Pot Synthesis of Nanoflower‐Like Zn2SnS4 as Nanozymes for Highly Sensitive Electrochemical Detection of H2O2 Released by Living Cells
    Xia Wen, Jiancong Ni, Shunmu Zeng, Zhiping Song, Weiwei Qiu
    Chemistry – A European Journal.2024;[Epub]     CrossRef
  • Lipopolysaccharide with long O-antigen is crucial for Salmonella Enteritidis to evade complement activity and to facilitate bacterial survival in vivo in the Galleria mellonella infection model
    Eva Krzyżewska-Dudek, Vinaya Dulipati, Katarzyna Kapczyńska, Mateusz Noszka, Carmen Chen, Juha Kotimaa, Marta Książczyk, Bartłomiej Dudek, Gabriela Bugla-Płoskońska, Krzysztof Pawlik, Seppo Meri, Jacek Rybka
    Medical Microbiology and Immunology.2024;[Epub]     CrossRef
  • Mogroside Alleviates Diabetes Mellitus and Modulates Intestinal Microflora in Type 2 Diabetic Mice
    Tiantian Qin, Yuqing Li, Yijing Wu, Fanyan Meng, Guobiao Lin, Xing Xia
    Biological and Pharmaceutical Bulletin.2024; 47(5): 1043.     CrossRef
  • Chronic PM2.5 exposure disrupts intestinal barrier integrity via microbial dysbiosis-triggered TLR2/5-MyD88-NLRP3 inflammasome activation
    Zihan Ran, Jingcheng Yang, Liang Liu, Shaobo Wu, YanPeng An, Wanwan Hou, Tianyuan Cheng, Youyi Zhang, Yiqing Zhang, Yechao Huang, Qianyue Zhang, Jiaping Wan, Xuemei Li, Baoling Xing, Yuchen Ye, Penghao Xu, Zhenghu Chen, Jinzhuo Zhao, Rui Li
    Environmental Research.2024; 258: 119415.     CrossRef
  • Silencing miR-155–5p expression improves intestinal damage through inhibiting inflammation and ferroptosis in necrotizing enterocolitis
    Le Zhang, Weilai Jin, Mengyuan Hu, Yinglin Su, Yiting Zhang, Fuqiang Yuan, Yuanyuan Fang, Zhengying Li, Yawen Li, Chaozhi Bu, Wenhao Zhou
    Heliyon.2024; 10(17): e37087.     CrossRef
  • Prebiotic properties of the polysaccharide from Rosa roxburghii Tratt fruit and its protective effects in high-fat diet-induced intestinal barrier dysfunction: A fecal microbiota transplantation study
    Lei Wang, Pan Zhang, Jie Chen, Chao Li, Yingpeng Tian, Fei Xu
    Food Research International.2023; 164: 112400.     CrossRef
  • Dietary fat induced chylomicron-mediated LPS translocation in a bicameral Caco-2cell model
    Monic M. M. Tomassen, Coen Govers, A. Paul Vos, Nicole J. W. de Wit
    Lipids in Health and Disease.2023;[Epub]     CrossRef
  • Endotoxemia and Gastrointestinal Cancers: Insight into the Mechanisms Underlying a Dangerous Relationship
    Vittoria Manilla, Natalia Di Tommaso, Francesco Santopaolo, Antonio Gasbarrini, Francesca Romana Ponziani
    Microorganisms.2023; 11(2): 267.     CrossRef
  • The regulatory effects of second-generation antipsychotics on lipid metabolism: Potential mechanisms mediated by the gut microbiota and therapeutic implications
    Hui Chen, Ting Cao, Bikui Zhang, Hualin Cai
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • Disturbance of intestinal permeability and its role in the development of cardiovascular complications in persons with inflammatory bowel diseases
    O. V. Khlynova, E. A. Stepina
    Experimental and Clinical Gastroenterology.2023; (11): 36.     CrossRef
  • Dietary supplementation of β-1, 3-glucan improves the intestinal health of white shrimp (Litopenaeus vannamei) by modulating intestinal microbiota and inhibiting inflammatory response
    Kaikai Shen, Lixin Bao, Muxin Liu, Wen Lei, Qin Zhou, Jiali Ding, Peng Fang, Baoqing Hu, Chungen Wen, Vikas Kumar, Mo Peng, Gang Yang
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Multi-Species Probiotic Strain Mixture Enhances Intestinal Barrier Function by Regulating Inflammation and Tight Junctions in Lipopolysaccharides Stimulated Caco-2 Cells
    Hyeontak Han, Yeji You, Soyoung Cha, Tae-Rahk Kim, Minn Sohn, Jeseong Park
    Microorganisms.2023; 11(3): 656.     CrossRef
  • Haslea ostrearia Pigment Marennine Affects Key Actors of Neuroinflammation and Decreases Cell Migration in Murine Neuroglial Cell Model
    Sarah Méresse, Hélène Gateau, Tessa Tirnan, Vanessa Larrigaldie, Nathalie Casse, Pamela Pasetto, Jean-Luc Mouget, Stéphane Mortaud, Mostefa Fodil
    International Journal of Molecular Sciences.2023; 24(6): 5388.     CrossRef
  • Optimal low-intensity pulsed ultrasound stimulation for promoting anti-inflammatory effects in macrophages
    Francesco Iacoponi, Andrea Cafarelli, Francesco Fontana, Tiziano Pratellesi, Erik Dumont, Ivana Barravecchia, Debora Angeloni, Leonardo Ricotti
    APL Bioengineering.2023;[Epub]     CrossRef
  • Dendrobium officinalis Six Nostrum Promotes Intestinal Urate Underexcretion via Regulations of Urate Transporter Proteins in Hyperuricemic Rats
    Hongzhang Ge, Zetian Jiang, Bo Li, Peiyao Xu, Hansong Wu, Xinglishang He, Wanfeng Xu, Zhi Huang, Taoxiu Xiong, Ping Wang, Guiyuan Lv, Suhong Chen
    Combinatorial Chemistry & High Throughput Screening.2023; 26(4): 848.     CrossRef
  • The effect of neuroinflammation on the cerebral metabolism at baseline and after neural stimulation in neurodegenerative diseases
    Fatima Cheataini, Nissrine Ballout, Tareq Al Sagheer
    Journal of Neuroscience Research.2023; 101(8): 1360.     CrossRef
  • Co-Stimulation of AGEs and LPS Induces Inflammatory Mediators through PLCγ1/JNK/NF-κB Pathway in MC3T3-E1 Cells
    Natsuko Tanabe, Keiko Tomita, Soichiro Manaka, Risa Ichikawa, Tadahiro Takayama, Takayuki Kawato, Misae Ono, Yuma Masai, Akihisa Utsu, Naoto Suzuki, Shuichi Sato
    Cells.2023; 12(10): 1383.     CrossRef
  • Inflammation o'clock: interactions of circadian rhythms with inflammation‐induced skeletal muscle atrophy
    Francielly Morena da Silva, Karyn A. Esser, Kevin A. Murach, Nicholas P. Greene
    The Journal of Physiology.2023;[Epub]     CrossRef
  • Salivary endotoxin detection using combined mono/polyclonal antibody-based sandwich-type lateral flow immunoassay device
    Daewoo Han, Sancai Xie, Andrew J. Steckl
    Sensors & Diagnostics.2023; 2(6): 1460.     CrossRef
  • An Update on the Therapeutic Potential of Antimicrobial Peptides against Acinetobacter baumannii Infections
    Karyne Rangel, Guilherme Curty Lechuga, David W. Provance, Carlos M. Morel, Salvatore G. De Simone
    Pharmaceuticals.2023; 16(9): 1281.     CrossRef
  • Gut–Brain Crosstalk and the Central Mechanisms of Orofacial Pain
    Ran Tao, Sufang Liu, Joshua Crawford, Feng Tao
    Brain Sciences.2023; 13(10): 1456.     CrossRef
  • Bacterial lipopolysaccharide inhibits colonic carrier-mediated uptake of thiamin pyrophosphate: roles for TLR4 receptor and NF-κB/P38/JNK signaling pathway
    Selvaraj Anthonymuthu, Subrata Sabui, Katherine Lee, Alaullah Sheikh, James M. Fleckenstein, Hamid M. Said
    American Journal of Physiology-Cell Physiology.2023; 325(3): C758.     CrossRef
  • Review of Phytochemical Potency as a Natural Anti-Helicobacter pylori and Neuroprotective Agent
    Yohanes Tandoro, Bo-Kai Chen, Asif Ali, Chin-Kun Wang
    Molecules.2023; 28(20): 7150.     CrossRef
  • Hyperimmune bovine colostrum containing lipopolysaccharide antibodies (IMM124-E) has a nondetrimental effect on gut microbial communities in unchallenged mice
    Rachele Gore, Mitra Mohsenipour, Jennifer L. Wood, Gayathri K. Balasuriya, Elisa L. Hill-Yardin, Ashley E. Franks, Manuela Raffatellu
    Infection and Immunity.2023;[Epub]     CrossRef
  • Decoding the role of gut microbiota in Alzheimer’s pathogenesis and envisioning future therapeutic avenues
    Junyi Liang, Bin Liu, Xiaohong Dong, Yueyang Wang, Wenhui Cai, Ning Zhang, Hong Zhang
    Frontiers in Neuroscience.2023;[Epub]     CrossRef
  • Of Soldiers and Their Ghosts: Are We Ready for a Review of PTSD Evidence?
    Adonis Sfera, Jonathan J. Anton, Hassan Imran, Zisis Kozlakidis, Carolina Klein, Carolina Osorio
    BioMed.2023; 3(4): 484.     CrossRef
  • Association of Endotoxemia with Low-Grade Inflammation, Metabolic Syndrome and Distinct Response to Lipopolysaccharide in Type 1 Diabetes
    Aleksejs Fedulovs, Leonora Pahirko, Kaspars Jekabsons, Liga Kunrade, Jānis Valeinis, Una Riekstina, Valdis Pīrāgs, Jelizaveta Sokolovska
    Biomedicines.2023; 11(12): 3269.     CrossRef
  • Intestinal Barrier Function and Immune Homeostasis Are Missing Links in Obesity and Type 2 Diabetes Development
    Sylvia Riedel, Carmen Pheiffer, Rabia Johnson, Johan Louw, Christo J. F. Muller
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • PPAR‐γ agonist pioglitazone alleviates inflammatory response induced by lipopolysaccharides in osteoblast cells
    Hua‐jun Yu, Lai‐jie Wang, Kai Huang, Qiao‐feng Guo, Bing‐yuan Lin, Yi‐yang Liu, Ming Yu, Gou‐ping Ma
    Journal of Orthopaedic Research.2022; 40(11): 2471.     CrossRef
  • Metformin attenuated sepsis-related liver injury by modulating gut microbiota
    Huoyan Liang, Heng Song, Xiaojuan Zhang, Gaofei Song, Yuze Wang, Xianfei Ding, Xiaoguang Duan, Lifeng Li, Tongwen Sun, Quancheng Kan
    Emerging Microbes & Infections.2022; 11(1): 815.     CrossRef
  • Periodontitis and cardiometabolic disorders: The role of lipopolysaccharide and endotoxemia
    Pirkko J. Pussinen, Elisa Kopra, Milla Pietiäinen, Markku Lehto, Svetislav Zaric, Susanna Paju, Aino Salminen
    Periodontology 2000.2022; 89(1): 19.     CrossRef
  • Response of periodontal ligament stem cells to lipopolysaccharide and calcium silicate-based materials
    Marlus da Silva Pedrosa, Handially dos Santos Vilela, Juliana Garuba Rahhal, Natália Pieretti Bueno, Fabianne Soares Lima, Fernando Neves Nogueira, Carla Renata Sipert
    Brazilian Dental Journal.2022; 33(2): 73.     CrossRef
  • Metformin Mitigates Sepsis-Related Neuroinflammation via Modulating Gut Microbiota and Metabolites
    Huayan Zhao, Yuanjun Lyu, Ruiqing Zhai, Guiying Sun, Xianfei Ding
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Anti-Inflammatory Effects of Mitrephora sirikitiae Leaf Extract and Isolated Lignans in RAW 264.7 Cells
    Supachoke Mangmool, Chayaporn Limpichai, Khine Kyi Han, Vichai Reutrakul, Natthinee Anantachoke
    Molecules.2022; 27(10): 3313.     CrossRef
  • The Effect of N-Acetylation on the Anti-Inflammatory Activity of Chitooligosaccharides and Its Potential for Relieving Endotoxemia
    Wentong Hao, Kecheng Li, Xiangyun Ge, Haoyue Yang, Chaojie Xu, Song Liu, Huahua Yu, Pengcheng Li, Ronge Xing
    International Journal of Molecular Sciences.2022; 23(15): 8205.     CrossRef
  • Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework
    Laure-Alix Clerbaux, Maria Cristina Albertini, Núria Amigó, Anna Beronius, Gillina F. G. Bezemer, Sandra Coecke, Evangelos P. Daskalopoulos, Giusy del Giudice, Dario Greco, Lucia Grenga, Alberto Mantovani, Amalia Muñoz, Elma Omeragic, Nikolaos Parissis, M
    Journal of Clinical Medicine.2022; 11(15): 4464.     CrossRef
  • Monoclonal Antibodies for Bacterial Pathogens: Mechanisms of Action and Engineering Approaches for Enhanced Effector Functions
    Fabiola Vacca, Claudia Sala, Rino Rappuoli
    Biomedicines.2022; 10(9): 2126.     CrossRef
  • Single-cell RNA analysis of chemokine expression in heterogeneous CD14+ monocytes with lipopolysaccharide-induced bone resorption
    Junpan Luo, Jiarui Lu, Jie Zeng, Yuanyuan Ma, Qimei Gong, Zhuyu Wang, Xiaolei Zhang, Jingjing Quan
    Experimental Cell Research.2022; 420(2): 113343.     CrossRef
  • Hydrogen Sulfide (H2S) Signaling as a Protective Mechanism against Endogenous and Exogenous Neurotoxicants
    Michael Aschner, Anatoly V. Skalny, Tao Ke, Joao BT da Rocha, Monica MB Paoliello, Abel Santamaria, Julia Bornhorst, Lu Rongzhu, Andrey A. Svistunov, Aleksandra B. Djordevic, Alexey A. Tinkov
    Current Neuropharmacology.2022; 20(10): 1908.     CrossRef
  • Gut as an Alternative Entry Route for SARS-CoV-2: Current Evidence and Uncertainties of Productive Enteric Infection in COVID-19
    Laure-Alix Clerbaux, Sally A. Mayasich, Amalia Muñoz, Helena Soares, Mauro Petrillo, Maria Cristina Albertini, Nicolas Lanthier, Lucia Grenga, Maria-Joao Amorim
    Journal of Clinical Medicine.2022; 11(19): 5691.     CrossRef
  • Probiotics Bacillus cereus and B. subtilis reshape the intestinal microbiota of Pengze crucian carp (Carassius auratus var. Pengze) fed with high plant protein diets
    Jiamin Li, Peng Fang, Xinwen Yi, Vikas Kumar, Mo Peng
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Biological functions of sialic acid as a component of bacterial endotoxin
    Bartłomiej Dudek, Jacek Rybka, Gabriela Bugla-Płoskońska, Agnieszka Korzeniowska-Kowal, Bożena Futoma-Kołoch, Aleksandra Pawlak, Andrzej Gamian
    Frontiers in Microbiology.2022;[Epub]     CrossRef
  • Interactions between gut microbiota and Parkinson's disease: The role of microbiota-derived amino acid metabolism
    Wang Wang, Shujun Jiang, Chengcheng Xu, Lili Tang, Yan Liang, Yang Zhao, Guoxue Zhu
    Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
  • Casein Oligochitosan-Glycation by Transglutaminase Enhances the Anti-Inflammatory Potential of Casein Hydrolysates to the Lipopolysaccharide-Stimulated IEC-6 Cells
    Na Chen, Li Wang, Qiang Zhang, Xin-Huai Zhao, Jia Shi
    Nutrients.2022; 14(3): 686.     CrossRef
  • Casein Lactose-Glycation of the Maillard-Type Attenuates the Anti-Inflammatory Potential of Casein Hydrolysate to IEC-6 Cells with Lipopolysaccharide Stimulation
    Na Chen, Yu Fu, Zhen-Xing Wang, Xin-Huai Zhao
    Nutrients.2022; 14(23): 5067.     CrossRef
  • Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions
    Shireen Mohammad, Christoph Thiemermann
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Serum 1,3-beta-D-glucan as a noninvasive test to predict histologic activity in patients with inflammatory bowel disease
    Katia Farias e Silva, Hayandra F Nanini, Cynthia Machado Cascabulho, Siane L B Rosas, Patricia T Santana, Antonio José de V Carneiro, Elias Anaissie, Marcio Nucci, Heitor Siffert Pereira de Souza
    World Journal of Gastroenterology.2021; 27(9): 866.     CrossRef
  • New Avenues for Parkinson’s Disease Therapeutics: Disease-Modifying Strategies Based on the Gut Microbiota
    Marina Lorente-Picón, Ariadna Laguna
    Biomolecules.2021; 11(3): 433.     CrossRef
  • The Relationship between the Gut Microbiome and Metformin as a Key for Treating Type 2 Diabetes Mellitus
    Chae Bin Lee, Soon Uk Chae, Seong Jun Jo, Ui Min Jerng, Soo Kyung Bae
    International Journal of Molecular Sciences.2021; 22(7): 3566.     CrossRef
  • Effect of condensed tannins on growth performance, intestinal immune capacity and bacterial microbiomes of Lateolabrax japonicus
    Kai Peng, Hongxia Zhao, Guoxia Wang, Bing Chen, Wenyan Mo, Yanhua Huang
    Aquaculture Research.2021; 52(11): 5321.     CrossRef
  • Effect of Ulinastatin on Early Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Surgery: A Systemic Review and Meta-Analysis
    Mei Duan, Fangyan Liu, Huiqun Fu, Shuai Feng, Xue Wang, Tianlong Wang
    Frontiers in Neuroscience.2021;[Epub]     CrossRef
  • Pathological and Therapeutic Approach to Endotoxin-Secreting Bacteria Involved in Periodontal Disease
    Rosalia Marcano, M. Ángeles Rojo, Damián Cordoba-Diaz, Manuel Garrosa
    Toxins.2021; 13(8): 533.     CrossRef
  • Research Progress of Ulinastatin in Preventing and Treating Postoperative Cognitive Dysfunction
    学英 陈
    Advances in Clinical Medicine.2021; 11(08): 3758.     CrossRef
  • The Potential for Phospholipids in the Treatment of Airway Inflammation: An Unexplored Solution
    Varsha Komalla, Meenu Mehta, Fatima Achi, Kamal Dua, Mehra Haghi
    Current Molecular Pharmacology.2021; 14(3): 333.     CrossRef
  • Fundamental and applied aspects of catechins from different sources: a review
    Alessandra Cristina Pedro, Giselle Maria Maciel, Valéria Rampazzo Ribeiro, Charles Windson Isidoro Haminiuk
    International Journal of Food Science & Technology.2020; 55(2): 429.     CrossRef
  • Recent Advances in Lipopolysaccharide Recognition Systems
    Lalita Mazgaeen, Prajwal Gurung
    International Journal of Molecular Sciences.2020; 21(2): 379.     CrossRef
  • miR-146b-5p Plays a Critical Role in the Regulation of Autophagy in ∆per Brucella melitensis-Infected RAW264.7 Cells
    Jiao Hanwei, Xin Nie, Huapei Zhu, Baobao Li, Feng Pang, Xiaohong Yang, Ruiyong Cao, Xiaojian Yang, Shu Zhu, Dongmei Peng, Yaying Li, Guohua Li, Zhenxing Zhang, Haifeng Huang, Kailian Xu, Tianjing Zhao, Ying Cheng, Chuangfu Chen, Li Du, Fengyang Wang
    BioMed Research International.2020; 2020: 1.     CrossRef
  • Cancer immunotherapy using a polysaccharide from Codium fragile in a murine model
    Hae-Bin Park, Seong-Min Lim, Juyoung Hwang, Wei Zhang, SangGuan You, Jun-O Jin
    OncoImmunology.2020;[Epub]     CrossRef
  • The influence of the gastrointestinal microbiome on infant colic
    Abdelhalim Ouald Chaib, Elvira Ingrid Levy, Mariam Ouald Chaib, Yvan Vandenplas
    Expert Review of Gastroenterology & Hepatology.2020; 14(10): 919.     CrossRef
  • MiR-141-3p ameliorates RIPK1-mediated necroptosis of intestinal epithelial cells in necrotizing enterocolitis
    Xiang Li, Ying Wang, Yijiang Wang, Xingbo He
    Aging.2020; 12(18): 18073.     CrossRef
  • Glucose transporter 4 mediates LPS-induced IL-6 production in osteoblasts under high glucose conditions
    Shunichiro Kato, Natsuko Tanabe, Mayu Nagao, Jumpei Sekino, Keiko Tomita, Mayu Sakai, Kimiko Abe, Naoto Suzuki, Koichiro Ueda
    Journal of Oral Science.2020; 62(4): 423.     CrossRef
  • Polyreactive Transformation of Class G Immunoglobulins as a Vector for Search of Potential Means for Improving the Activity of Anti-endotoxin Immunity
    A. I. Gordienko, N. V. Khimich, V. A. Beloglazov, A. V. Kubyshkin, M. Yu. Yakovlev
    Human Physiology.2020; 46(5): 554.     CrossRef
  • A P4 medicine perspective of gut microbiota and prediabetes: Systems analysis and personalized intervention
    Qiongrong Huang, Qiaojun Fang, Zhiyuan Hu
    Journal of Translational Internal Medicine.2020; 8(3): 119.     CrossRef
  • Role of the Microbiota in the Modulation of Vaccine Immune Responses
    Annalisa Ciabattini, Raffaela Olivieri, Elisa Lazzeri, Donata Medaglini
    Frontiers in Microbiology.2019;[Epub]     CrossRef
  • Microchip electrophoretic detection of bacterial lipopolysaccharide based on aptamer-modified magnetic beads and polymerase chain amplification
    Zhi Li, Feifei Luo, Ge Dai, Yuqi Lu, Shiyun Ai, Pingang He, Qingjiang Wang
    Microchemical Journal.2019; 150: 104178.     CrossRef
  • Comparison of inflammatory cytokine-inducing activity of lipopolysaccharides from major periodontal bacteria
    So-Hee Kim, In-Chol Kang
    International Journal of Oral Biology.2019; 44(4): 160.     CrossRef
  • Lipopolysaccharide induces tumor necrosis factor receptor-1 independent relocation of lymphocytes from the red pulp of the mouse spleen
    Ivana M. Lalić, Rudolf Bichele, Anja Repar, Sanja Z. Despotović, Saša Petričević, Martti Laan, Pärt Peterson, Jürgen Westermann, Živana Milićević, Ivana Mirkov, Novica M. Milićević
    Annals of Anatomy - Anatomischer Anzeiger.2018; 216: 125.     CrossRef
  • Evasion of Human Neutrophil-Mediated Host Defense duringToxoplasma gondiiInfection
    Tatiane S. Lima, Lanny Gov, Melissa B. Lodoen, Louis M. Weiss
    mBio.2018;[Epub]     CrossRef
  • Effects of short-term dietary restriction and glutamine supplementation in vitro on the modulation of inflammatory properties
    Dalila C. de Oliveira, Ed Wilson Santos, Amanda Nogueira-Pedro, José Guilherme Xavier, Primavera Borelli, Ricardo Ambrósio Fock
    Nutrition.2018; 48: 96.     CrossRef
  • Dysbiosis of gut microbiota and microbial metabolites in Parkinson’s Disease
    Meng-Fei Sun, Yan-Qin Shen
    Ageing Research Reviews.2018; 45: 53.     CrossRef
  • Ulinastatin May Significantly Improve Postoperative Cognitive Function of Elderly Patients Undergoing Spinal Surgery by Reducing the Translocation of Lipopolysaccharide and Systemic Inflammation
    Min Zhang, Yan-Hua Zhang, Hui-Qun Fu, Qing-Ming Zhang, Tian-Long Wang
    Frontiers in Pharmacology.2018;[Epub]     CrossRef
  • Antimicrobial Peptides: Mechanisms of Action and Resistance
    B. Bechinger, S.-U. Gorr
    Journal of Dental Research.2017; 96(3): 254.     CrossRef
  • Effects of cyanobacteria Oscillatoria sp. lipopolysaccharide on B cell activation and Toll-like receptor 4 signaling
    Michelle Swanson-Mungerson, Ryan Incrocci, Vijay Subramaniam, Philip Williams, Mary L. Hall, Alejandro M.S. Mayer
    Toxicology Letters.2017; 275: 101.     CrossRef
  • Low-intensity pulsed ultrasound inhibits lipopolysaccharide-induced IL-6 and RANKL expression in osteoblasts
    Mayu Nagao, Natsuko Tanabe, Soichiro Manaka, Tadahiro Takayama, Takayuki Kawato, Go Torigoe, Jumpei Sekino, Naoya Tsukune, Manami Ozaki, Masao Maeno, Naoto Suzuki, Shuichi Sato
    Journal of Oral Science.2017; 59(2): 303.     CrossRef
  • Conformational Dynamics of the Lipopolysaccharide from Escherichia coli O91 Revealed by Nuclear Magnetic Resonance Spectroscopy and Molecular Simulations
    Pilar Blasco, Dhilon S. Patel, Olof Engström, Wonpil Im, Göran Widmalm
    Biochemistry.2017; 56(29): 3826.     CrossRef
  • RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146
    Yoshinori Matsumoto, Jose Larose, Oliver A. Kent, Melissa Lim, Adele Changoor, Lucia Zhang, Yaryna Storozhuk, Xiaohong Mao, Marc D. Grynpas, Feng Cong, Robert Rottapel
    Journal of Clinical Investigation.2017; 127(4): 1303.     CrossRef
  • Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity
    Aila J Ahola, Mariann I. Lassenius, Carol Forsblom, Valma Harjutsalo, Markku Lehto, Per-Henrik Groop
    Scientific Reports.2017;[Epub]     CrossRef
  • MicroRNA mediated regulation of immunity against gram-negative bacteria
    Jonathon Keck, Rishein Gupta, Lane K. Christenson, Bernard P. Arulanandam
    International Reviews of Immunology.2017; 36(5): 287.     CrossRef
  • Mogroside IIIE Attenuates LPS‐Induced Acute Lung Injury in Mice Partly Through Regulation of the TLR4/MAPK/NF‐κB Axis via AMPK Activation
    Lijun Tao, Fengyan Cao, Gonghao Xu, Haifeng Xie, Mian Zhang, Chaofeng Zhang
    Phytotherapy Research.2017; 31(7): 1097.     CrossRef
  • Changes in serum levels of lipopolysaccharides and CD26 in patients with Crohn's disease
    Daniéla Oliveira Magro, Paulo Gustavo Kotze, Carlos Augusto Real Martinez, Michel Gardere Camargo, Dioze Guadagnini, Antonio Ramos Calixto, Ana Carolina Junqueira Vasques, Maria de Lourdes Setsuko Ayrizono, Bruno Geloneze, José Carlos Pareja, Mario José S
    Intestinal Research.2017; 15(3): 352.     CrossRef
  • LIPUS suppressed LPS‐induced IL‐1α through the inhibition of NF‐κB nuclear translocation via AT1‐PLCβ pathway in MC3T3‐E1 cells
    Mayu Nagao, Natsuko Tanabe, Soichiro Manaka, Masako Naito, Jumpei Sekino, Tadahiro Takayama, Takayuki Kawato, Go Torigoe, Shunichiro Kato, Naoya Tsukune, Masao Maeno, Naoto Suzuki, Shuichi Sato
    Journal of Cellular Physiology.2017; 232(12): 3337.     CrossRef
  • Autophagy can alleviate severe burn-induced damage to the intestinal tract in mice
    Duanyang Zhang, Wei Qiu, Peng Wang, Pan Zhang, Fang Zhang, PeiP. Wang, Yong Sun
    Surgery.2017; 162(2): 408.     CrossRef
  • Protective effect of wogonin on endotoxin‐induced acute lung injury via reduction of p38 MAPK and JNK phosphorylation
    Cheng‐Yu Wei, Hai‐Lun Sun, Ming‐Ling Yang, Ching‐Ping Yang, Li‐You Chen, Yi‐Ching Li, Chien‐Ying Lee, Yu‐Hsiang Kuan
    Environmental Toxicology.2017; 32(2): 397.     CrossRef
  • Lipopolysaccharide from Crypt-Specific Core Microbiota Modulates the Colonic Epithelial Proliferation-to-Differentiation Balance
    Tomoaki Naito, Céline Mulet, Cristina De Castro, Antonio Molinaro, Azadeh Saffarian, Giulia Nigro, Marion Bérard, Mélanie Clerc, Amy B. Pedersen, Philippe J. Sansonetti, Thierry Pédron, B. Brett Finlay, Andrew Gewirtz, Kevin Foster, Scott Hultgren
    mBio.2017;[Epub]     CrossRef
  • Effects of lipopolysaccharide on the histomorphology and expression of toll-like receptor 4 in the chicken trachea and lung
    Abdur Rahman Ansari, Xiao-Hong Ge, Hai-Bo Huang, Xi-Yao Huang, Xing Zhao, Ke-Mei Peng, Ju-Ming Zhong, Hua-Zhen Liu
    Avian Pathology.2016; 45(5): 530.     CrossRef
  • Can Proton Pump Inhibitors Increase Incidence of Nonsteroidal Anti-inflammatory Drug-induced Small Bowel Injury?
    Seong Ran Jeon
    The Korean Journal of Gastroenterology.2016; 68(2): 123.     CrossRef
  • Inflammatory stimuli promote growth and invasion of pancreatic cancer cells through NF-κB pathway dependent repression of PP2Ac
    Min Tao, Lu Liu, Meng Shen, Qiaoming Zhi, Fei-Ran Gong, Binhua P. Zhou, Yadi Wu, Haiyan Liu, Kai Chen, Bairong Shen, Meng-Yao Wu, Liu-Mei Shou, Wei Li
    Cell Cycle.2016; 15(3): 381.     CrossRef
  • Ligustrazine disrupts lipopolysaccharide-activated NLRP3 inflammasome pathway associated with inhibition of Toll-like receptor 4 in hepatocytes
    Feng Zhang, Huanhuan Jin, Li Wu, Jiangjuan Shao, Xiafei Wu, Yin Lu, Shizhong Zheng
    Biomedicine & Pharmacotherapy.2016; 78: 204.     CrossRef
  • Polyphenol extracts interfere with bacterial lipopolysaccharide in vitro and decrease postprandial endotoxemia in human volunteers
    Ximena Wong, Ana María Madrid, Karina Tralma, Romina Castillo, Catalina Carrasco-Pozo, Paola Navarrete, Caroll Beltrán, Edgar Pastene, Martin Gotteland
    Journal of Functional Foods.2016; 26: 406.     CrossRef
  • A20 inhibits lipopolysaccharide-induced inflammation in enterocytes
    Cui-Fang Zheng, Jie-Ru Shi, Ying Huang, Sheng-Nan Wang
    World Journal of Gastrointestinal Pharmacology and Therapeutics.2016; 7(4): 540.     CrossRef
  • Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease
    Francesca Pistollato, Sandra Sumalla Cano, Iñaki Elio, Manuel Masias Vergara, Francesca Giampieri, Maurizio Battino
    Nutrition Reviews.2016; 74(10): 624.     CrossRef
  • Human gut microbiota and healthy aging: Recent developments and future prospective
    Manish Kumar, Parizad Babaei, Boyang Ji, Jens Nielsen
    Nutrition and Healthy Aging.2016; 4(1): 3.     CrossRef
  • The dormant blood microbiome in chronic, inflammatory diseases
    Marnie Potgieter, Janette Bester, Douglas B. Kell, Etheresia Pretorius, Prof. Antoine Danchin
    FEMS Microbiology Reviews.2015; 39(4): 567.     CrossRef
  • The C-terminal Domain Supports a Novel Function for CETPI as a New Plasma Lipopolysaccharide-Binding Protein
    Victor García-González, Nadia Gutiérrez-Quintanar, Jaime Mas-Oliva
    Scientific Reports.2015;[Epub]     CrossRef
  • Interactions between Autophagy and Bacterial Toxins: Targets for Therapy?
    Jacques Mathieu
    Toxins.2015; 7(8): 2918.     CrossRef
  • Calcitonin gene‐related peptide: key regulator of cutaneous immunity
    R. D. Granstein, J. A. Wagner, L. L. Stohl, W. Ding
    Acta Physiologica.2015; 213(3): 586.     CrossRef
  • 11,300 View
  • 125 Download
  • 95 Web of Science
  • 99 Crossref
Close layer
Corticotropin-releasing Hormone and Its Biological Diversity toward Angiogenesis
Eunok Im
Intest Res 2014;12(2):96-102.   Published online April 29, 2014
DOI: https://doi.org/10.5217/ir.2014.12.2.96
AbstractAbstract PDFPubReader

Angiogenesis is the formation of new blood vessels from existing ones and an underlying cause of numerous human diseases, including cancer and inflammation. A large body of evidence indicates that angiogenic inhibitors have therapeutic potential in the treatment of vascular diseases. However, detrimental side effects and low efficacy hinder their use in clinical practice. Members of the corticotropin-releasing hormone (CRH) family, which comprises CRH, urocortin I-III, and CRH receptors (CRHR) 1 and 2, are broadly expressed in the brain and peripheral tissues, including the intestine and cardiovascular system. The CRH family regulates stress-related responses through the hypothalamic-pituitary-adrenal axis. Therapeutic agents that target CRH family members offer a new approach to the treatment of various gastrointestinal disorders, including irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and colorectal cancer. Since the discovery that CRHR 2 has anti-angiogenic activity during postnatal development in mice, studies have focused on the role of the CRH system in the modulation of blood vessel formation and cardiovascular function. This review will outline the basic biological functions of the CRH family members and the implications for the development of novel anti-angiogenic therapies.

Citations

Citations to this article as recorded by  
  • Vascular anomalies in Koolen‐de Vries syndrome: Expanding the spectrum of cutaneous findings
    María Trinidad Hasbun Zegpi, Daniela Alfaro‐Sepúlveda, Luisa Schonhaut Berman, Cecilia Mellado Sagredo
    JEADV Clinical Practice.2024; 3(2): 726.     CrossRef
  • The peripheral corticotropin releasing factor family's role in vasculitis
    Chao Zhu, Shengnan Li
    Vascular Pharmacology.2024; 154: 107275.     CrossRef
  • Disentangling the common genetic architecture and causality of rheumatoid arthritis and systemic lupus erythematosus with COVID‐19 outcomes: Genome‐wide cross trait analysis and bidirectional Mendelian randomization study
    Minhao Yao, Xin Huang, Yunshan Guo, Jie V. Zhao, Zhonghua Liu
    Journal of Medical Virology.2023;[Epub]     CrossRef
  • Steroid utility, immunotherapy, and brain tumor management: an update on conflicting therapies
    Matthew Goldman, Brandon Lucke-Wold, Meleine Martinez-Sosa, Jason Katz, Yusuf Mehkri, Jeff Valisno, Stephan Quintin
    Exploration of Targeted Anti-tumor Therapy.2022; : 659.     CrossRef
  • Corticotropin-Releasing Hormone Receptor Alters the Tumor Development and Growth in Apcmin/+ Mice and in a Chemically-Induced Model of Colon Cancer
    Yunna Lee, Elise L. Ma, Marisa Patel, Gayoung Kim, Cody Howe, Charalabos Pothoulakis, Yong Sung Kim, Eunok Im, Sang Hoon Rhee
    International Journal of Molecular Sciences.2021; 22(3): 1043.     CrossRef
  • Cancer-Specific Loss of Urocortin 3 in Human Renal Cancer
    Pouriya Faraj Tabrizi, Anahit Mohebbi Tafrechi, Inga Peters, Faranaz Atschekzei, Markus Antonius Kuczyk, Jürgen Serth, Hossein Tezval
    Advances in Therapy.2020; 37(1): 288.     CrossRef
  • Methylation Status of Transcriptional Modulatory Genes Associated with Colorectal Cancer in Northeast China
    Han-Lu Gao, Xuan Wang, Hong-Ru Sun, Jun-De Zhou, Shang-Qun Lin, Yu-Hang Xing, Lin Zhu, Hai-Bo Zhou, Ya-Shuang Zhao, Qiang Chi, Yu-Peng Liu
    Gut and Liver.2018; 12(2): 173.     CrossRef
  • CRHR2/Ucn2 signaling is a novel regulator of miR‐7/YY1/Fas circuitry contributing to reversal of colorectal cancer cell resistance to Fas‐mediated apoptosis
    Charalabos Pothoulakis, Monica Torre‐Rojas, Marco A. Duran‐Padilla, Jonathan Gevorkian, Odysseas Zoras, Emmanuel Chrysos, George Chalkiadakis, Stavroula Baritaki
    International Journal of Cancer.2018; 142(2): 334.     CrossRef
  • Angiogenesis in Inflammatory Bowel Disease
    Canan Alkim, Huseyin Alkim, Ali Riza Koksal, Salih Boga, Ilker Sen
    International Journal of Inflammation.2015; 2015: 1.     CrossRef
  • P7, a novel antagonist of corticotropin releasing factor receptor type 1 (CRFR1) screened from phage display library
    Jinmei Yu, Rengong Zhuo, Peng Peng, Xiaoyan Liu, Haitao Yan, Shuzhuo Zhang, Jianquan Zheng, Xiaoli Wei, Xiaoyun Ma
    Biochemical and Biophysical Research Communications.2015; 463(3): 200.     CrossRef
  • Corticotropin-releasing factor mediates bone cancer induced pain through neuronal activation in rat spinal cord
    Hou-bao Fan, Ting Zhang, Kai Sun, Su-pei Song, Shou-bin Cao, Hai-long Zhang, Wen Shen
    Tumor Biology.2015; 36(12): 9559.     CrossRef
  • Corticotropin Releasing Hormone and Urocortin 3 Stimulate Vascular Endothelial Growth Factor Expression through the cAMP/CREB Pathway
    Sang Hoon Rhee, Elise L. Ma, Yunna Lee, Yvette Taché, Charalabos Pothoulakis, Eunok Im
    Journal of Biological Chemistry.2015; 290(43): 26194.     CrossRef
  • 5,415 View
  • 63 Download
  • 11 Web of Science
  • 12 Crossref
Close layer
Natural Product-Derived Drugs for the Treatment of Inflammatory Bowel Diseases
Young-Eun Joo
Intest Res 2014;12(2):103-109.   Published online April 29, 2014
DOI: https://doi.org/10.5217/ir.2014.12.2.103
AbstractAbstract PDFPubReader

Natural products have been used as drugs for millennia, and the therapeutic potential of natural products has been studied for more than a century. Since the mid-1880s, approximately 60% of drugs have originated from natural products. Recently, the importance of using natural products has increased, as has interest in discovering efficient new drugs. Natural drugs are desirable for the treatment of inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease. This review discusses the discovery and development of drugs derived from natural products for the treatment of inflammatory bowel diseases.

Citations

Citations to this article as recorded by  
  • Boswellic Acids: A Critical Appraisal of Their Therapeutic and Nutritional Benefits in Chronic Inflammatory Diseases
    Neeta Solanki, Gaurav Gupta, Dinesh Kumar Chellappan, Sachin Kumar Singh, Monica Gulati, Keshav Raj Paudel, Philip M Hansbro, Kamal Dua, Suraj Bhan, Manisha Saini, Harish Dureja
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2024; 24(1): 116.     CrossRef
  • Approaches, Strategies and Procedures for Identifying Anti-Inflammatory Drug Lead Molecules from Natural Products
    Tenzin Jamtsho, Karma Yeshi, Matthew J. Perry, Alex Loukas, Phurpa Wangchuk
    Pharmaceuticals.2024; 17(3): 283.     CrossRef
  • Natural approaches for the management of ulcerative colitis: evidence of preclinical and clinical investigations
    Rudra Narayan Subudhi, Neelam Poonia, Dilpreet Singh, Vimal Arora
    Natural Products and Bioprospecting.2024;[Epub]     CrossRef
  • A brief overview of the medicinal and nutraceutical importance of Inonotus obliquus (chaga) mushrooms
    Emma Camilleri, Renald Blundell, Bikash Baral, Tomasz M. Karpinski, Edlira Aruci, Omar M. Atrooz
    Heliyon.2024; 10(15): e35638.     CrossRef
  • Phytotherapy and Drugs: Can Their Interactions Increase Side Effects in Cancer Patients?
    Sarah Allegra, Silvia De Francia, Francesca Turco, Ilenia Bertaggia, Francesco Chiara, Tiziana Armando, Silvana Storto, Maria Valentina Mussa
    Journal of Xenobiotics.2023; 13(1): 75.     CrossRef
  • Ion exchange pattern-based 18β-glycyrrhetinic acid containing pyridinium salts derivatives as novel antibacterial agents with low toxicity
    Jing-Jing He, Ting Li, Hong-Wu Liu, Lin-Li Yang, Yi-Hong Yang, Qing-Qing Tao, Xiang Zhou, Pei-Yi Wang, Song Yang
    Arabian Journal of Chemistry.2023; 16(6): 104771.     CrossRef
  • Effective bioactive compounds and their antiviral properties from some selected aquatic plants through in silico and in vitro approaches
    Kuntal Das, Paramita Das, Supriya Mana
    Aquaculture.2023; 573: 739574.     CrossRef
  • Physico-chemical, microbiological, and sensory characteristics of yogurt as affected by various ingredients
    Ricardo S. Aleman, Roberto Cedillos, Ryan Page, Douglas Olson, Kayanush Aryana
    Journal of Dairy Science.2023; 106(6): 3868.     CrossRef
  • In vitro Antioxidant Potential and In vivo Analgesic and Anti-Inflammatory Activities of Moroccan Equisetum ramosissimum
    Saida Sissi, Loubna Ait Dra, Soukaina Ouhaddou, Ouhammou Ahmed, Mustapha Larhsini, Mohammed Markouk
    The Natural Products Journal.2023;[Epub]     CrossRef
  • Microbiomic and Metabolomic Analyses Unveil the Protective Effect of Saffron in a Mouse Colitis Model
    Gulshan Singh, Hassan Brim, Yeneneh Haileselassie, Sudhir Varma, Aida Habtezion, Mudasir Rashid, Sidhartha R. Sinha, Hassan Ashktorab
    Current Issues in Molecular Biology.2023; 45(7): 5558.     CrossRef
  • Mechanisms and therapeutic actions of edible fruits in inflammatory bowel disease: A review of pre-clinical studies
    Karuppusamy Arunachalam, Puthanpura Sasidharan Sreeja, Xuefei Yang
    Food Chemistry Advances.2023; 3: 100498.     CrossRef
  • Aproximaciones evolutivas en etnobotánica de plantas medicinales y bioprospección
    Madeleyne Cupido, José Arturo De-Nova, Virginia Gabriela Cilia-López
    Botanical Sciences.2023; 102(1): 26.     CrossRef
  • Bioactive compounds, antibacterial and antioxidant activities of methanol extract of Tamarindus indica Linn.
    Kehinde Oluwakemi Fagbemi, Daniel Ayandiran Aina, Morenike Olutunmbi Adeoye-Isijola, Kubendran Kista Naidoo, Roger Murugas Coopoosamy, Olufunmiso Olusola Olajuyigbe
    Scientific Reports.2022;[Epub]     CrossRef
  • Molecular docking investigation of anti-inflammatory herbal compounds as potential LOX-5 and COX-2 inhibitors
    Liliia Vyshnevska, Hanna I. Severina, Yuliya Prokopenko, Alexander Shmalko
    Pharmacia.2022; 69(3): 733.     CrossRef
  • A Review on Structure-Activity Relationships of Glycyrrhetinic Acid Derivatives with Diverse Bioactivities
    Yuebin Liu, Ruilong Sheng, Junting Fan, Ruihua Guo
    Mini-Reviews in Medicinal Chemistry.2022; 22(15): 2024.     CrossRef
  • Effects of molecular weight on intestinal anti-inflammatory activities of β-D-glucan from Ganoderma lucidum
    Yanfang Liu, Qingjiu Tang, Jie Feng, Jing Liu, Chuanhong Tang, Mengqiu Yan, Shuai Zhou, Liping Liu, Jing Zhou, Jingsong Zhang
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Protective Effect of Dietary Polysaccharides from Yellow Passion Fruit Peel on DSS-Induced Colitis in Mice
    Laryssa Regis Bueno, Bruna da Silva Soley, Kahlile Youssef Abboud, Isabella Wzorek França, Karien Sauruk da Silva, Natalia Mulinari Turin de Oliveira, Juliana Santos Barros, Marcelo Biondaro Gois, Lucimara Mach Côrtes Cordeiro, Daniele Maria-Ferreira, And
    Oxidative Medicine and Cellular Longevity.2022; 2022: 1.     CrossRef
  • Recent progress of bacterial FtsZ inhibitors with a focus on peptides
    Huihui Han, Zhenlong Wang, Ting Li, Da Teng, Ruoyu Mao, Ya Hao, Na Yang, Xiumin Wang, Jianhua Wang
    The FEBS Journal.2021; 288(4): 1091.     CrossRef
  • Rational Optimization of 1,2,3-Triazole-Tailored Carbazoles As Prospective Antibacterial Alternatives with Significant In Vivo Control Efficiency and Unique Mode of Action
    Xing Huang, Hong-Wu Liu, Zhou-Qing Long, Zhen-Xing Li, Jian-Jun Zhu, Pei-Yi Wang, Pu-Ying Qi, Li-Wei Liu, Song Yang
    Journal of Agricultural and Food Chemistry.2021; 69(16): 4615.     CrossRef
  • Molecular Engineering of Curcumin, an Active Constituent of Curcuma longa L. (Turmeric) of the Family Zingiberaceae with Improved Antiproliferative Activity
    Amena Ali, Abuzer Ali, Abu Tahir, Md. Afroz Bakht, Salahuddin, Mohamed Jawed Ahsan
    Plants.2021; 10(8): 1559.     CrossRef
  • Middle Eastern Plant Extracts: An Alternative to Modern Medicine Problems
    Disha Varijakzhan, Chou-Min Chong, Aisha Abushelaibi, Kok-Song Lai, Swee-Hua Erin Lim
    Molecules.2020; 25(5): 1126.     CrossRef
  • Anti‐inflammatory effect of hydrolyzed celery leaves extract in murine primary splenocyte
    Jae Young Shin, Denis Nchang Che, Byoung Ok Cho, Hyun Ju Kang, Ji‐su Kim, Seon Il Jang
    Journal of Food Biochemistry.2019;[Epub]     CrossRef
  • Design, Synthesis, Antibacterial Evaluation, and Induced Apoptotic Behaviors of Epimeric and Chiral 18β-Glycyrrhetinic Acid Ester Derivatives with an Isopropanolamine Bridge against Phytopathogens
    Meng Xiang, Xiang Zhou, Ting-Rong Luo, Pei-Yi Wang, Li-Wei Liu, Zhong Li, Zhi-Bing Wu, Song Yang
    Journal of Agricultural and Food Chemistry.2019; 67(48): 13212.     CrossRef
  • GC-MS Analysis and Gastroprotective Evaluations of Crude Extracts, Isolated Saponins, and Essential Oil from Polygonum hydropiper L.
    Muhammad Ayaz, Muhammad Junaid, Farhat Ullah, Abdul Sadiq, Muhammad Shahid, Waqar Ahmad, Ihsan Ullah, Ashfaq Ahmad, Nawazish-i-Husain Syed
    Frontiers in Chemistry.2017;[Epub]     CrossRef
  • Chlorogenic acid suppresses lipopolysaccharide-induced nitric oxide and interleukin-1β expression by inhibiting JAK2/STAT3 activation in RAW264.7 cells
    Sang-Hun Kim, Sun-Young Park, Young-Lan Park, Dae-Seong Myung, Jong-Sun Rew, Young-Eun Joo
    Molecular Medicine Reports.2017; 16(6): 9224.     CrossRef
  • Dietary supplementation of GrandFusion® mitigates cerebral ischemia-induced neuronal damage and attenuates inflammation
    Jin Yu, Hong Zhu, Sebastiano Gattoni-Celli, Saeid Taheri, Mark Stephen Kindy
    Nutritional Neuroscience.2016; 19(7): 290.     CrossRef
  • The Traditional Medicine and Modern Medicine from Natural Products
    Haidan Yuan, Qianqian Ma, Li Ye, Guangchun Piao
    Molecules.2016; 21(5): 559.     CrossRef
  • Orally available extract from Brassica oleracea var. capitata rubra attenuates experimental colitis in mouse models of inflammatory bowel diseases
    Marta Zielińska, Urszula Lewandowska, Anna Podsędek, Adam I. Cygankiewicz, Damian Jacenik, Maciej Sałaga, Radzisław Kordek, Wanda M. Krajewska, Jakub Fichna
    Journal of Functional Foods.2015; 17: 587.     CrossRef
  • Allium cepaL. and Quercetin Inhibit RANKL/Porphyromonas gingivalisLPS-Induced Osteoclastogenesis by Downregulating NF-κB Signaling Pathway
    Tatiane Oliveira, Camila A. Figueiredo, Carlos Brito, Alexander Stavroullakis, Ana Carolina Ferreira, Getulio Nogueira-Filho, Anuradha Prakki
    Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1.     CrossRef
  • Rice prolamin extract ameliorates acute murine colitis by inhibiting nuclear factor-kappa B and modulating intestinal apoptosis and cell proliferation
    C-Y Chung, Y-L Park, N Kim, H-H Oh, D-S Myung, J-S Kim, S-B Cho, W-S Lee, H-S Kim, B-W Ahn, Y-E Joo
    Clinical and Experimental Immunology.2014; 178(3): 537.     CrossRef
  • 11,118 View
  • 163 Download
  • 32 Web of Science
  • 30 Crossref
Close layer
Colonoscopy Quality is the Answer for the Emerging Issue of Interval Cancer
Jae Myung Cha
Intest Res 2014;12(2):110-116.   Published online April 29, 2014
DOI: https://doi.org/10.5217/ir.2014.12.2.110
AbstractAbstract PDFPubReader

Colonoscopy is currently regarded as the gold standard and preferred screening method for colorectal cancer (CRC). Recently, however, a limitation of colonoscopy in the prevention of CRCs has been identified, particularly in the right-sided colon, and the problem of so-called interval cancers has emerged. The prevalence of interval cancer is estimated to be between 4% and 8% of CRCs detected. Although the exact etiology of interval cancer remains unknown, factors implicated in the development of interval cancers include missed lesions at the time of colonoscopy, incomplete resection of previous neoplastic lesions, different tumor biology, and serrated pathway of carcinogenesis. However, recent evidence suggests that interval cancers are related to the training of the endoscopist and quality of the colonoscopy rather than tumor biology. Therefore, the importance of adequate training and continuous monitoring of the colonoscopy quality, which are amenable to improvement, cannot be overstated in order to prevent the risk of interval cancers. In this study, the current literature regarding the prevalence and potential factors related to interval cancers and colonoscopy quality-related issues are reviewed.

Citations

Citations to this article as recorded by  
  • Detection of sessile serrated adenoma using artificial intelligence‐enhanced endoscopy: an Asian perspective
    Joycelyn Mun‐Peng Soo, Frederick Hong‐Xiang Koh
    ANZ Journal of Surgery.2024; 94(3): 362.     CrossRef
  • Strategies to improve screening colonoscopy quality for the prevention of colorectal cancer
    Joo Hye Song, Eun Ran Kim
    The Korean Journal of Internal Medicine.2024; 39(4): 547.     CrossRef
  • Cáncer gástrico de intervalo: un llamado a la atención y a la acción
    R. Castaño-Llano, A. Piñeres, R. Jaramillo, S. Molina, F. Aristizábal, J.E. Puerta
    Revista de Gastroenterología de México.2023; 88(2): 91.     CrossRef
  • Interval gastric cancer: A call to attentiveness and action
    R. Castaño-Llano, A. Piñeres, R. Jaramillo, S. Molina, F. Aristizábal, J.E. Puerta
    Revista de Gastroenterología de México (English Edition).2023; 88(2): 91.     CrossRef
  • Effect of music on colonoscopy performance: A propensity score-matched analysis
    Eun Jeong Choi, Sam Ryong Jee, Sang Heon Lee, Jun Sik Yoon, Seung Jung Yu, Jong Hyun Lee, Han Byul Lee, Sang Wook Yi, Myeong Pyo Kim, Byung Cheol Chung, Hong Sub Lee
    World Journal of Gastrointestinal Endoscopy.2023; 15(5): 397.     CrossRef
  • Clinical characteristics and outcome of iatrogenic colonic perforation related to diagnostic vs. therapeutic colonoscopy
    Ra Ri Cha, Hee Jin Kim, Chang Min Lee, Jae Min Lee, Sang Soo Lee, Hyun Jin Cho, Chang Yoon Ha, Hyun Jin Kim, Ok-Jae Lee
    Surgical Endoscopy.2022; 36(8): 5938.     CrossRef
  • Comparison of adenoma detection by colonoscopy between polypectomy performed during both insertion and withdrawal versus during withdrawal only: a multicenter, randomized, controlled trial
    Tae-Geun Gweon, Seung-Woo Lee, Jeong-Seon Ji, Jeong Rok Lee, Joon Sung Kim, Byung-Wook Kim, Hwang Choi
    Surgical Endoscopy.2020; 34(12): 5461.     CrossRef
  • Faecal immunochemical tests versus colonoscopy for post-polypectomy surveillance: an accuracy, acceptability and economic study
    Wendy Atkin, Amanda J Cross, Ines Kralj-Hans, Eilidh MacRae, Carolyn Piggott, Sheena Pearson, Kate Wooldrage, Jeremy Brown, Fiona Lucas, Aaron Prendergast, Natalie Marchevsky, Bhavita Patel, Kevin Pack, Rosemary Howe, Hanna Skrobanski, Robert Kerrison, Ni
    Health Technology Assessment.2019; 23(1): 1.     CrossRef
  • Relationship between the polyp detection rate and the post-colonoscopy colorectal cancer rate
    Violeta María Sastre Lozano, Senador Morán Sánchez, José García Solano, Pablo Conesa Zamora, Guadalupe Ruiz Merino
    Revista Española de Enfermedades Digestivas.2019;[Epub]     CrossRef
  • The incidence and clinical associated factors of interval colorectal cancers in Southern Taiwan
    Cheng-En Tsai, Keng-Liang Wu, Yi-Chun Chiu, Seng-Kee Chuah, Wei-Chen Tai, Ming-Luen Hu, Chih-Ming Liang
    Journal of the Formosan Medical Association.2018; 117(3): 185.     CrossRef
  • Three-year colonoscopy surveillance after polypectomy in Korea: a Korean Association for the Study of Intestinal Diseases (KASID) multicenter prospective study
    Won Seok Choi, Dong Soo Han, Chang Soo Eun, Dong Il Park, Jeong-Sik Byeon, Dong-Hoon Yang, Sung-Ae Jung, Sang Kil Lee, Sung Pil Hong, Cheol Hee Park, Suck-Ho Lee, Jeong-Seon Ji, Sung Jae Shin, Bora Keum, Hyun Soo Kim, Jung Hye Choi, Sin-Ho Jung
    Intestinal Research.2018; 16(1): 126.     CrossRef
  • Risk of advanced colorectal neoplasm by the proposed combined United States and United Kingdom risk stratification guidelines
    Soo-Kyung Park, Hyo-Joon Yang, Yoon Suk Jung, Jung Ho Park, Chong Il Sohn, Dong Il Park
    Gastrointestinal Endoscopy.2018; 87(3): 800.     CrossRef
  • Predictive factors for missed adenoma on repeat colonoscopy in patients with suboptimal bowel preparation on initial colonoscopy: A KASID multicenter study
    Ji Young Chang, Chang Mo Moon, Hyun Jung Lee, Hyo-Joon Yang, Yunho Jung, Sang Wook Kim, Sung-Ae Jung, Jeong-Sik Byeon, Frank T. Kolligs
    PLOS ONE.2018; 13(4): e0195709.     CrossRef
  • Frequency and Characteristics of Interval Colorectal Cancer in Actual Clinical Practice: A KASID Multicenter Study
    Kyeong Ok Kim, Kyu Chan Huh, Sung Pil Hong, Won Hee Kim, Hyuk Yoon, Sang Wook Kim, Yeon Soo Kim, Jong Ha Park, Jun Lee, Bum Jae Lee, Young Sook Park
    Gut and Liver.2018; 12(5): 537.     CrossRef
  • The Short-term Outcome and Safety of Laparoscopic Colorectal Cancer Resection in Very Elderly Patients
    Won Beom Jung, Jin Yong Shin, Byoung Jo Suh
    The Korean Journal of Gastroenterology.2017; 69(5): 291.     CrossRef
  • External Validation of the Endoscopic Features of Sessile Serrated Adenomas in Expert and Trainee Colonoscopists
    Hyo-Joon Yang, Jeong In Lee, Soo-Kyung Park, Yoon Suk Jung, Jin Hee Sohn, Kyu Yong Choi, Dong Il Park
    Clinical Endoscopy.2017; 50(3): 279.     CrossRef
  • Risk Factors Such as Male Sex, Smoking, Metabolic Syndrome, Obesity, and Fatty Liver Do Not Justify Screening Colonoscopies Before Age 45
    Yoon Suk Jung, Kyung Eun Yun, Yoosoo Chang, Seungho Ryu, Dong Il Park
    Digestive Diseases and Sciences.2016; 61(4): 1021.     CrossRef
  • The Characteristics of Colorectal Invasive Cancers Detected within 5 years after Colonoscopy
    Seiji Kimura, Masanori Tanaka, Shinsaku Fukuda
    Nippon Daicho Komonbyo Gakkai Zasshi.2016; 69(3): 147.     CrossRef
  • Do Serrated Polyps Increase the Risk of Colorectal Cancer Development?
    Su Hwan Kim, Ji Won Kim
    The Korean Journal of Gastroenterology.2016; 67(3): 161.     CrossRef
  • Comparative Study on Bowel Preparation Efficacy of Ascorbic Acid Containing Polyethylene Glycol by Adding Either Simethicone or 1 L of Water in Health Medical Examination Patients: A Prospective Randomized Controlled Study
    Se Hwan Yeo, Jae Hoon Kwak, Yeo Un Kim, Tae Ho Kwon, Jeong Bae Park, Jun Hyung Park, Yong Kook Lee, Yun Jeong Lim, Chang Heon Yang
    The Korean Journal of Gastroenterology.2016; 67(4): 189.     CrossRef
  • Risk of Colorectal Neoplasia According to Fatty Liver Severity and Presence of Gall Bladder Polyps
    Taeyoung Lee, Kyung Eun Yun, Yoosoo Chang, Seungho Ryu, Dong Il Park, Kyuyong Choi, Yoon Suk Jung
    Digestive Diseases and Sciences.2016; 61(1): 317.     CrossRef
  • Risk of Advanced Colorectal Neoplasia According to the Number of High-Risk Findings at Index Colonoscopy: A Korean Association for the Study of Intestinal Disease (KASID) Study
    Yoon Suk Jung, Dong Il Park, Won Hee Kim, Chang Soo Eun, Soo-Kyung Park, Bong Min Ko, Geom Seog Seo, Jae Myung Cha, Jae Jun Park, Kyeong Ok Kim, Chang Mo Moon, Yunho Jung, Eun Soo Kim, Seong Ran Jeon, Chang Kyun Lee
    Digestive Diseases and Sciences.2016; 61(6): 1661.     CrossRef
  • Associations between amount of smoking and alcohol intake and risk of colorectal neoplasm
    Yoon Suk Jung, Hwanseok Jung, Kyung Eun Yun, Seungho Ryu, Yoosoo Chang, Dong Il Park, Kyuyong Choi
    Journal of Gastroenterology and Hepatology.2016; 31(4): 788.     CrossRef
  • Fecal hemoglobin concentration is useful for risk stratification of advanced colorectal neoplasia
    Nam Hee Kim, Min-Jung Kwon, Hyun-young Kim, Taeheon Lee, Seok Hyeon Jeong, Dong Il Park, Kyuyong Choi, Yoon Suk Jung
    Digestive and Liver Disease.2016; 48(6): 667.     CrossRef
  • Microsatellite Instability Status of Interval Colorectal Cancers in a Korean Population
    Kil Woo Lee, Soo-Kyung Park, Hyo-Joon Yang, Yoon Suk Jung, Kyu Yong Choi, Kyung Eun Kim, Kyung Uk Jung, Hyung Ook Kim, Hungdai Kim, Ho-Kyung Chun, Dong Il Park
    Gut and Liver.2016; 10(5): 781.     CrossRef
  • Comparison of adenoma detection rate and adenoma per colonoscopy as a quality indicator of colonoscopy
    Soo-Kyung Park, Hyun-Young Kim, Chang Kyun Lee, Jae Myung Cha, Chang Soo Eun, Dong Soo Han, Bo-In Lee, Jeong Eun Shin, Dong Il Park
    Scandinavian Journal of Gastroenterology.2016; 51(7): 886.     CrossRef
  • Comparable Efficacy of a 1-L PEG and Ascorbic Acid Solution Administered with Bisacodyl versus a 2-L PEG and Ascorbic Acid Solution for Colonoscopy Preparation: A Prospective, Randomized and Investigator-Blinded Trial
    Ji Eun Kwon, Jung Won Lee, Jong Pil Im, Ji Won Kim, Su Hwan Kim, Seong-Joon Koh, Byeong Gwan Kim, Kook Lae Lee, Sang Gyun Kim, Joo Sung Kim, Hyun Chae Jung, John Green
    PLOS ONE.2016; 11(9): e0162051.     CrossRef
  • Colon Transit Time May Predict Inadequate Bowel Preparation in Patients With Chronic Constipation
    Hong Jun Park, Myeong Hun Chae, Hyun-Soo Kim, Jae Woo Kim, Moon Young Kim, Soon Koo Baik, Sang Ok Kwon, Hee Man Kim, Kyong Joo Lee
    Intestinal Research.2015; 13(4): 339.     CrossRef
  • Lessons from Interval Gastric Cancer: Read between the Lines
    Byung-Wook Kim
    Gut and Liver.2015; 9(2): 133.     CrossRef
  • Randomized Controlled Trial of Sodium Phosphate Tablets versus 2 L Polyethylene Glycol Solution for Bowel Cleansing prior to Colonoscopy
    Yun Ho Lee, Seong Yeon Jeong, You Sun Kim, Hye Jin Jung, Min Jung Kwon, Cheol Hun Kwak, Song I Bae, Jeong Seop Moon, Ji Won Kim, Su Hwan Kim, Kook Lae Lee
    The Korean Journal of Gastroenterology.2015; 65(1): 27.     CrossRef
  • Associations Between Parameters of Glucose and Lipid Metabolism and Risk of Colorectal Neoplasm
    Yoon Suk Jung, Seungho Ryu, Yoosoo Chang, Kyung Eun Yun, Jung Ho Park, Hong Joo Kim, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Kyuyong Choi, Dong Il Park
    Digestive Diseases and Sciences.2015; 60(10): 2996.     CrossRef
  • 5,811 View
  • 65 Download
  • 26 Web of Science
  • 31 Crossref
Close layer
Original Articles
Clinical and Endoscopic Recurrence after Surgical Resection in Patients with Crohn's Disease
Yang Woon Lee, Kang-Moon Lee, Woo Chul Chung, Chang Nyol Paik, Hea Jung Sung, You Suk Oh
Intest Res 2014;12(2):117-123.   Published online April 29, 2014
DOI: https://doi.org/10.5217/ir.2014.12.2.117
AbstractAbstract PDFPubReader
<b>Background/Aims</b><br/>

The natural history of Crohn's disease (CD) is characterized by a remitting and relapsing course and a considerable number of patients ultimately require bowel resection. Moreover, postoperative recurrence is very common. Relatively few studies have investigated the postoperative recurrence of CD in Korea. The aim of the current study was to assess postoperative recurrence rates - both clinical and endoscopic - in CD as well as factors influencing postoperative recurrence.

Methods

Electronic medical records of patients who underwent surgery due to CD were reviewed and analyzed. Patients with incomplete surgical resection, a follow-up period of less than a year, and a history of strictureplasty or perianal surgery were excluded.

Results

Of 112 CD patients, 39 patients had history of bowel resection, and 34 patients met the inclusion criteria. Among them, 26 were male (76%) and the mean age of onset was 32.8 years. The mean follow-up period after operation was 65.4 months. Cumulative clinical recurrence rates were 8.8%, 12.5%, and 33.5% at 12, 24, and 48 months, respectively. Use of immunomodulators for prophylaxis was the only predictor of clinical recurrence in univariate analysis (P=0.042). Of 21 patients who had undergone follow-up colonoscopy after surgery, cumulative endoscopic recurrence rates were 33.3%, 42.9%, and 66.1% at 6, 12, and 24 months, respectively. No significant predicting factor for endoscopic recurrence was detected.

Conclusions

Postoperative recurrence rates in Korean patients with CD are high, and endoscopic recurrence rates are comparable to those reported from Western studies. Appropriate medical prophylaxis seems to be important for preventing postoperative recurrence in CD.

Citations

Citations to this article as recorded by  
  • Small bowel pyloric metaplasia is associated with lower rates of earlier recurrence of Crohn's disease after resection
    Jennifer Y. Ju, David J. Escobar, Yue Xue, Adam L. Booth, Jessica Nguyen, Guang-Yu Yang
    Human Pathology.2024; 151: 105629.     CrossRef
  • The Relationship Between Endoscopic and Clinical Recurrence in Postoperative Crohn’s Disease: A Systematic Review and Meta-analysis
    Alessandro Ble, Cecilia Renzulli, Fabio Cenci, Maria Grimaldi, Michelangelo Barone, Rocio Sedano, Joshua Chang, Tran M Nguyen, Malcolm Hogan, Guangyong Zou, John K MacDonald, Christopher Ma, William J Sandborn, Brian G Feagan, Emilio Merlo Pich, Vipul Jai
    Journal of Crohn's and Colitis.2022; 16(3): 490.     CrossRef
  • Predictors of postoperative recurrence in a cohort of Tunisian patients with Crohn’s disease
    Aya Hammami, Raida Harbi, Nour Elleuch, Khaled Ben Meddeb, Wafa Ben Ameur, Wafa Dahmani, Ahlem Braham, Salem Ajmi, Mehdi Ksiaa, Aida Ben Slama, Hanen Jaziri, Ali Jmaa
    Therapeutic Advances in Gastrointestinal Endoscopy.2022; 15: 263177452110606.     CrossRef
  • Risk Factors for Postoperative Recurrence in Korean Patients with Crohn’s Disease
    Sung Bae Kim, Jae Hee Cheon, Jae Jun Park, Eun Soo Kim, Seong Woo Jeon, Sung-Ae Jung, Dong Il Park, Chang Kyun Lee, Jong Pil Im, You Sun Kim, Hyun Soo Kim, Jun Lee, Chang Soo Eun, Jeong Mi Lee, Byung Ik Jang, Geom Seog Seo
    Gut and Liver.2020; 14(3): 331.     CrossRef
  • Monitoring Disease Activity: How and When?
    Kang-Moon Lee
    The Korean Journal of Gastroenterology.2018; 71(2): 69.     CrossRef
  • Prebiotic Supplementation Following Ileocecal Resection in a Murine Model is Associated With a Loss of Microbial Diversity and Increased Inflammation
    Michael Laffin, Troy Perry, Heekuk Park, Naomi Hotte, Richard N Fedorak, Aducio Thiesen, Bryan Dicken, Karen L Madsen
    Inflammatory Bowel Diseases.2018; 24(1): 101.     CrossRef
  • Postoperative course of Crohn disease according to timing of bowel resection
    Ji Min Lee, Kang-Moon Lee, Joo Sung Kim, You Sun Kim, Jae Hee Cheon, Byong Duk Ye, Young-Ho Kim, Dong Soo Han, Chang Kyun Lee, Hyun-Ju Park
    Medicine.2018; 97(16): e0459.     CrossRef
  • Efficacy of Adalimumab in Korean Patients with Crohn's Disease
    Il Woong Sohn, Sung Tae Kim, Bun Kim, Hyun Jung Lee, Soo Jung Park, Sung Pil Hong, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
    Gut and Liver.2016; 10(2): 255.     CrossRef
  • Patients with perianal Crohn's disease have poor disease outcomes after primary bowel resection
    Yoo Min Han, Ji Won Kim, Seong‐Joon Koh, Byeong Gwan Kim, Kook Lae Lee, Jong Pil Im, Joo Sung Kim, Hyun Chae Jung
    Journal of Gastroenterology and Hepatology.2016; 31(8): 1436.     CrossRef
  • Indications and Specific Surgical Techniques in Crohn's Disease
    Claudia Seifarth, Martin E. Kreis, Jörn Gröne
    Visceral Medicine.2015; 31(4): 273.     CrossRef
  • What is the Important Issue to Prevent the Postoperative Crohn's Disease?
    You Sun Kim
    Intestinal Research.2014; 12(2): 85.     CrossRef
  • Endoscopic Postoperative Recurrence Rates in Crohn's Disease in Korea: The Beginning of a New Approach?
    Paulo Gustavo Kotze, Rogerio Saad-Hossne, Antonino Spinelli
    Intestinal Research.2014; 12(3): 258.     CrossRef
  • Author's Reply
    Kang-Moon Lee
    Intestinal Research.2014; 12(3): 260.     CrossRef
  • Crohn's disease in Korea: past, present, and future
    Kang-Moon Lee, Ji Min Lee
    The Korean Journal of Internal Medicine.2014; 29(5): 558.     CrossRef
  • 5,714 View
  • 78 Download
  • 12 Web of Science
  • 14 Crossref
Close layer
Vaccination and Complementary and Alternative Medicine in Patients with Inflammatory Bowel Disease
Sung Bae Kim, Soo Jung Park, Sook Hee Chung, Kyu Yeon Hahn, Do Chang Moon, Sung Pil Hong, Jae Hee Cheon, Tae Il Kim, Won Ho Kim
Intest Res 2014;12(2):124-130.   Published online April 29, 2014
DOI: https://doi.org/10.5217/ir.2014.12.2.124
AbstractAbstract PDFPubReader
<b>Background/Aims</b><br/>

Vaccinations in patients with inflammatory bowel disease (IBD) are recommended to prevent infectious diseases. However, there are few reports of vaccination in IBD patients in Korea. The frequency of complementary and alternative medicine (CAM) use is high despite its uncertain effectiveness. This study aimed to identify the rates of vaccination and use of CAM in patients with IBD.

Methods

A total of 219 patients attended an education session for IBD patients held at Severance Hospital on March 23, 2013. We conducted a survey on vaccination and CAM use in IBD patients; 120 patients completed the questionnaire.

Results

The influenza vaccination rate was 44.2% and pneumococcal vaccination rate was 4.2%. Thirty-one (66%) patients were aware of the importance of vaccination. The vaccination rate was higher in patients who were aware of the importance of vaccination compared with that in patients who were unaware of the importance of vaccination (70.1% vs. 41.7%, P=0.004). The rate of CAM use was 30.0%. The most commonly used CAMs were oral products: vitamins (33.3%), red ginseng (25.0%), and probiotics (19.4%).

Conclusions

Awareness of the importance of vaccination and actual vaccination rates were low in IBD patients. Despite insufficient evidence on the effectiveness of CAMs in IBD patients, many patients used CAMs. We believe that repeated education and promotion of vaccination are important. Further large-scale studies to investigate the efficacy and safety of CAMs are warranted in patients with IBD.

Citations

Citations to this article as recorded by  
  • Factors associated with the prescription of probiotics in patients with inflammatory bowel disease: a cross-sectional study
    Joo Kyung Kim, Jae Hee Cheon
    Journal of Yeungnam Medical Science.2023; 40(1): 37.     CrossRef
  • Adherence to Recommended Immunization Schedules in Patients with Inflammatory Bowel Disease on Biologics and Small Molecule Therapies
    Mohammad Shehab, Ranim Almatar, Rawan Almohammad, Ahmad Alfadhli
    Gastroenterology Insights.2023; 14(3): 383.     CrossRef
  • SARS-CoV-2 vaccination for adult patients with inflammatory bowel disease: expert consensus statement by KASID
    Yoo Jin Lee, Seong-Eun Kim, Yong Eun Park, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seung-Jae Myung
    Intestinal Research.2022; 20(2): 171.     CrossRef
  • Vaccinations and inflammatory bowel disease – a systematic review
    Webber Chan, Ennaliza Salazar, Teong Guan Lim, Wan Chee Ong, Hang Hock Shim
    Digestive and Liver Disease.2021; 53(9): 1079.     CrossRef
  • SARS-CoV-2 Vaccination for Adult Patients with Inflammatory Bowel Disease: Expert Consensus Statements by KASID
    Yoo Jin Lee, Seong-Eun Kim, Yong Eun Park, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seung-Jae Myung
    The Korean Journal of Gastroenterology.2021; 78(2): 117.     CrossRef
  • A recent update on the use of Chinese medicine in the treatment of inflammatory bowel disease
    Lin Yang, Hua Luo, Dechao Tan, Siyuan Zhang, Zhangfeng Zhong, Shengpeng Wang, Chi Teng Vong, Yitao Wang
    Phytomedicine.2021; 92: 153709.     CrossRef
  • Insufficient vaccination and inadequate immunization rates among Korean patients with inflammatory bowel diseases
    Han Hee Ryu, Kiju Chang, Nayoung Kim, Ho-Su Lee, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
    Medicine.2021; 100(45): e27714.     CrossRef
  • Complementary and alternative medicine in patients with inflammatory bowel disease: hype or evidence?
    Jae Myung Cha
    Intestinal Research.2020; 18(2): 141.     CrossRef
  • Complementary and Alternative Medicine Use in Children With Inflammatory Bowel Disease
    Uma P. Phatak, Arik Alper, Dinesh S. Pashankar
    Journal of Pediatric Gastroenterology and Nutrition.2019; 68(2): 157.     CrossRef
  • Prevalence and indicators of use of complementary and alternative medicine in Austrian patients with inflammatory bowel disease
    Hans Peter Gröchenig, Thomas Waldhör, Thomas Haas, Heimo Wenzl, Pius Steiner, Robert Koch, Thomas Feichtenschlager, Gerald Eckhardt, Andreas Mayer, Andreas Kirchgatterer, Othmar Ludwiczek, Reingard Platzer, Pavol Papay, Johanna Gartner, Harry Fuchssteiner
    European Journal of Gastroenterology & Hepatology.2019; 31(10): 1211.     CrossRef
  • The who-when-why triangle of complementary and alternative medicine use among Portuguese IBD patients
    Francisco Portela, Camila C. Dias, Paulo Caldeira, Marilia Cravo, João Deus, Raquel Gonçalves, Paula Lago, Henrique Morna, Paula Peixe, Jaime Ramos, Helena Sousa, Lurdes Tavares, Helena Vasconcelos, Fernando Magro, Paula Ministro
    Digestive and Liver Disease.2017; 49(4): 388.     CrossRef
  • Chlorogenic acid suppresses lipopolysaccharide-induced nitric oxide and interleukin-1β expression by inhibiting JAK2/STAT3 activation in RAW264.7 cells
    Sang-Hun Kim, Sun-Young Park, Young-Lan Park, Dae-Seong Myung, Jong-Sun Rew, Young-Eun Joo
    Molecular Medicine Reports.2017; 16(6): 9224.     CrossRef
  • Vaccination in Inflammatory Bowel Disease Patients: Attitudes, Knowledge, and Uptake
    Gurtej Malhi, Amir Rumman, Reka Thanabalan, Kenneth Croitoru, Mark S. Silverberg, A. Hillary Steinhart, Geoffrey C. Nguyen
    Journal of Crohn's and Colitis.2015; 9(6): 439.     CrossRef
  • Ideal Vaccination Strategy in Inflammatory Bowel Disease
    Chang Kyun Lee
    The Korean Journal of Gastroenterology.2015; 65(3): 159.     CrossRef
  • 6,084 View
  • 80 Download
  • 14 Web of Science
  • 14 Crossref
Close layer
Clinicopathological Characteristics of Colon Cancer Diagnosed at Primary Health Care Institutions
Sang Hyun Park, Chi Wook Song, Yun Bae Kim, Young Sun Kim, Hwang Rae Chun, Jung Hyun Lee, Won Jong Seol, Hyung Sun Yoon, Myung Kwon Lee, Jong Hyup Lee, Choon Sang Bhang, Jae Hyung Park, Ji Young Park, Byung Hun Do, Young Dae Park, Sang Jeong Yoon, Chan Wook Park, Su Mi Yoon, Jong Hwan Choi, Ki Chul Shin, Dong Hoon Ko, Young Jin Kim, Dong Choon Seol
Intest Res 2014;12(2):131-138.   Published online April 29, 2014
DOI: https://doi.org/10.5217/ir.2014.12.2.131
AbstractAbstract PDFPubReader
<b>Background/Aims</b><br/>

The purpose of this study was to evaluate the clinicopathologic characteristics of colon cancers detected at the SOK Sokpeynhan Internal Medical Network, a nationwide system of primary health care institutions.

Methods

We analyzed 579 colon cancer patients diagnosed using colonoscopy at the SOK network from January 2011 through December 2012. Cancers from the rectum to the splenic flexure were classified as left colon cancer. Patients over 65 were classified as senior.

Results

The mean age (±SD) of subjects was 60.9±10.5 years and 61.1% were men. More than one quarter (28.2%) of patients were asymptomatic. The prevalence of left colon cancer was higher (77.9%) than that for right colon cancer. The most frequent macroscopic and histologic types were depressed (58.9%) and moderately differentiated adenocarcinoma (52.2%), respectively. Asymptomatic subjects displayed protruding or well differentiated adenocarcinoma, while symptomatic patients were more likely to display depressed or moderately differentiated adenocarcinoma (P<0.05). The mean age of the right colon cancer group was higher than that for the left colon cancer group (P<0.05). Among symptomatic patients, the most frequent symptoms were bloody stool for patients with left colon cancer and abdominal discomfort for patients with right colon cancer (P<0.05). The prevalence of depressed cancer was higher in older subjects as compared to younger subjects (P<0.05). The prevalence of right colon cancer tended to increase with age, although this difference did not achieve statistical significance (P>0.05).

Conclusions

Study results indicated an increase of colon cancer amongst younger demographics in recent years. The effectiveness of colonoscopy screening was also evident, as asymptomatic patients demonstrated frequent findings of well differentiated adenocarcinomas. Study results also suggested a need for closer examination of older patients, as right colon cancer tended to increase with age.

Citations

Citations to this article as recorded by  
  • Obstructive sleep apnea is associated with an increased risk of colorectal neoplasia
    Seohui Lee, Byeong Gwan Kim, Ji Won Kim, Kook Lae Lee, Dae Lim Koo, Hyunwoo Nam, Jong Pil Im, Joo Sung Kim, Seong-Joon Koh
    Gastrointestinal Endoscopy.2017; 85(3): 568.     CrossRef
  • The Short-term Outcome and Safety of Laparoscopic Colorectal Cancer Resection in Very Elderly Patients
    Won Beom Jung, Jin Yong Shin, Byoung Jo Suh
    The Korean Journal of Gastroenterology.2017; 69(5): 291.     CrossRef
  • Malformin A1 treatment alters invasive and oncogenic phenotypes of human colorectal cancer cells through stimulation of the p38 signaling pathway
    Sun-Young Park, Hyung-Hoon Oh, Young-Lan Park, Hyung-Min Yu, Dae-Seong Myung, Sung-Bum Cho, Wan-Sik Lee, Daeho Park, Young-Eun Joo
    International Journal of Oncology.2017; 51(3): 959.     CrossRef
  • Impact of KITENIN on tumor angiogenesis and lymphangiogenesis in colorectal cancer
    HYUNG-HOON OH, KANG-JIN PARK, NURI KIM, SUN-YOUNG PARK, YOUNG-LAN PARK, CHAN-YOUNG OAK, DAE-SEONG MYUNG, SUNG-BUM CHO, WAN-SIK LEE, KYUNG-KEUN KIM, YOUNG-EUN JOO
    Oncology Reports.2016; 35(1): 253.     CrossRef
  • Do Serrated Polyps Increase the Risk of Colorectal Cancer Development?
    Su Hwan Kim, Ji Won Kim
    The Korean Journal of Gastroenterology.2016; 67(3): 161.     CrossRef
  • Molecular correlates and prognostic value of tmTNF-α expression in colorectal cancer of 5-Fluorouracil-Based Adjuvant Therapy
    Xiaogai Li, Shihai Wang, HuiJun Ren, Junfen Ma, Xiaoxu Sun, Nan Li, Cailin Liu, Kaida Huang, Min Xu, Liang Ming
    Cancer Biology & Therapy.2016; 17(6): 684.     CrossRef
  • Synergistic Effects of Simvastatin and Irinotecan against Colon Cancer Cells with or without Irinotecan Resistance
    Hyun Joo Jang, Eun Mi Hong, Juah Jang, Jung Eun Choi, Se Woo Park, Hyun Woo Byun, Dong Hee Koh, Min Ho Choi, Sea Hyub Kae, Jin Lee
    Gastroenterology Research and Practice.2016; 2016: 1.     CrossRef
  • Risk of developing advanced colorectal neoplasia after removing high‐risk adenoma detected at index colonoscopy in young patients: A KASID study
    Soo‐Kyung Park, Nam Hee Kim, Yoon Suk Jung, Won Hee Kim, Chang Soo Eun, Bong Min Ko, Geom Seog Seo, Jae Myung Cha, Jae Jun Park, Kyeong Ok Kim, Chang Mo Moon, Yoonho Jung, Eun Soo Kim, Seong Ran Jeon, Chang Kyun Lee, Dong Il Park
    Journal of Gastroenterology and Hepatology.2016; 31(1): 138.     CrossRef
  • Effect of Recepteur d'Origine Nantais expression on chemosensitivity and tumor cell behavior in colorectal cancer
    NURI KIM, SUNG-BUM CHO, YOUNG-LAN PARK, SUN-YOUNG PARK, EUN MYUNG, SEUNG-HUN KIM, HYUNG-MIN YU, YOUNG-AE SON, DAE-SEONG MYUNG, WAN-SIK LEE, YOUNG-EUN JOO
    Oncology Reports.2016; 35(6): 3331.     CrossRef
  • Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer
    Hyun Joo Jang, Eun Mi Hong, Mikang Kim, Jae Hyun Kim, Juah Jang, Se Woo Park, Hyun Wu Byun, Dong Hee Koh, Min Ho Choi, Sea Hyub Kae, Jin Lee
    Oncotarget.2016; 7(29): 46219.     CrossRef
  • Filamin A interacting protein 1-like expression inhibits progression in colorectal cancer
    Young-Lan Park, Sun-Young Park, Seung-Hyun Lee, Rul-Bin Kim, Joong-Keun Kim, Sung-Yoon Rew, Dae-Seong Myung, Sung-Bum Cho, Wan-Sik Lee, Hyun-Soo Kim, Young-Eun Joo
    Oncotarget.2016; 7(44): 72229.     CrossRef
  • Risk Factors for Delayed Post-Polypectomy Bleeding
    Min Jung Kwon, You Sun Kim, Song I Bae, Young Il Park, Kyung Jin Lee, Jung Hwa Min, Soo Yeon Jo, Mi Young Kim, Hye Jin Jung, Seong Yeon Jeong, Won Jae Yoon, Jin Nam Kim, Jeong Seop Moon
    Intestinal Research.2015; 13(2): 160.     CrossRef
  • Clinicopathological Characteristics of Newly Diagnosed Colorectal Cancers in Community Gastroenterology Practice
    Chang Kyun Lee
    Intestinal Research.2014; 12(2): 87.     CrossRef
  • 6,430 View
  • 53 Download
  • 13 Web of Science
  • 13 Crossref
Close layer
Does Metformin Affect The Incidence of Colonic Polyps and Adenomas in Patients with Type 2 Diabetes Mellitus?
Youn Hee Cho, Bong Min Ko, Shin Hee Kim, Yu Sik Myung, Jong Hyo Choi, Jae Pil Han, Su Jin Hong, Seong Ran Jeon, Hyun Gun Kim, Jin Oh Kim, Moon Sung Lee
Intest Res 2014;12(2):139-145.   Published online April 29, 2014
DOI: https://doi.org/10.5217/ir.2014.12.2.139
AbstractAbstract PDFPubReader
<b>Background/Aims</b><br/>

Colorectal cancer (CRC) develops from colonic adenomas. Type 2 diabetes mellitus (DM) is associated with a higher risk of CRC and metformin decreases CRC risk. However, it is not certain if metformin affects the development of colorectal polyps and adenomas. This study aimed to elucidate if metforminaffects the incidence of colonic polyps and adenomas in patients with type 2 DM.

Methods

Of 12,186 patients with type 2 DM, 3,775 underwent colonoscopy between May 2001 and March 2013. This study enrolled 3,105 of these patients, and divided them in two groups: 912 patients with metformin use and 2,193 patients without metformin use. Patient clinical characteristics, polyp and adenoma detection rate in the two groups were analyzed retrospectively.

Results

The Colorectal polyp detection rate was lower in the metformin group than in the non-meformin group (39.4% vs. 62.4%, P<0.01). Colorectal adenoma detection rate was significantly lower in the metformin group than in the non-metformin group (15.2% vs. 20.5%, P<0.01). Fewer advanced adenomas were detected in the metformin group than in the non-metformin group (12.2% vs. 22%, P<0.01). Multivariate analysis identified age, sex, Body mass index and metformin use as factors associated with polyp incidence, whereas only metforminwas independently associated with decreased adenoma incidence (Odd ratio=0.738, 95% CI=0.554-0.983, P=0.03).

Conclusions

In patients with type 2 DM, metformin reduced the incidence of adenomas that may transform into CRC. Therefore, metformin may be useful for the prevention of CRC in patients with type 2 DM.

Citations

Citations to this article as recorded by  
  • Is Metformin Associated with a Lower Prevalence of Polyps, Adenomas, and Colorectal Carcinoma in Patients with Diabetes Mellitus?
    Maria Inês Canha, Gonçalo Ramos, Rita Prata, Pedro Lages Martins, Marta Viúla Ramos, João Coimbra
    Journal of Gastrointestinal Cancer.2024; 55(1): 435.     CrossRef
  • Metformin administration in prevention of colorectal polyps in type 2 diabetes mellitus patients
    Xiao-Qing Wu, Li-Hua Deng, Qian Xue, Xia Li, Meng-Han Li, Jing-Tong Wang
    World Journal of Clinical Cases.2024; 12(20): 4206.     CrossRef
  • Anti-cancer Efficacy of Metformin: Recent Updates on Breast and Other Cancers
    Md. Imtiazul Kabir, Robin Kumar, Lakshmi Sai Pratyusha Bugata, Komal Raina
    Current Pharmacology Reports.2023; 9(5): 284.     CrossRef
  • Metformin Use Is Inversely Associated with Prevalent, but Not Incident Colorectal Adenomas
    Anna Krigel, Snow Trinh T. Nguyen, Nawar Talukder, Ching-Ho Huang, Carlos Buitrago, Gabriel Karkenny, Benjamin Lebwohl, Julian A. Abrams, James L. Araujo
    Digestive Diseases and Sciences.2022; 67(10): 4886.     CrossRef
  • Effect of metformin on thyroid cancer risk in patients with acromegaly: A preliminary observational study
    Cem Sulu, Ayyuce Begum Bektas, Suleyman Sami Guzel, Kubilay Tay, Serdar Sahin, Emre Durcan, Hande Mefkure Ozkaya, Pinar Kadioglu
    Growth Hormone & IGF Research.2022; 66: 101484.     CrossRef
  • Metformin Modifies the Gut Microbiota of Mice Infected with Helicobacter pylori
    Marine Jauvain, Sarah Courtois, Philippe Lehours, Emilie Bessède
    Pharmaceuticals.2021; 14(4): 329.     CrossRef
  • Bovine Meat and Milk Factors (BMMFs): Their Proposed Role in Common Human Cancers and Type 2 Diabetes Mellitus
    Ethel-Michele de Villiers, Harald zur Hausen
    Cancers.2021; 13(21): 5407.     CrossRef
  • Suppressive effects of metformin on colorectal adenoma incidence and malignant progression
    Min Deng, Siqin Lei, Dongdong Huang, Hui Wang, Shuli Xia, Enping Xu, Yihua Wu, Honghe Zhang
    Pathology - Research and Practice.2020; 216(2): 152775.     CrossRef
  • Use of metformin and risk of breast and colorectal cancer
    Gad Rennert, Hedy S. Rennert, Naomi Gronich, Mila Pinchev, Stephen B. Gruber
    Diabetes Research and Clinical Practice.2020; 165: 108232.     CrossRef
  • Diabetes Mellitus: a Clinical Condition Associated with Metabolic Syndrome and Colorectal Cancer Risk
    Vesna Brzacki, Aleksandar Nagorni, Manolis Kallistratos, Athanasios Manolis, Dragan Lovic
    Current Pharmacology Reports.2019; 5(4): 205.     CrossRef
  • Diabetes Mellitus and Colon Carcinogenesis: Expectation for Inhibition of Colon Carcinogenesis by Oral Hypoglycemic Drugs
    Junichi Kato, Yohei Shirakami, Masahito Shimizu
    Gastrointestinal Disorders.2019; 1(2): 273.     CrossRef
  • Metformin in colorectal cancer: molecular mechanism, preclinical and clinical aspects
    Muhamad Noor Alfarizal Kamarudin, Md. Moklesur Rahman Sarker, Jin-Rong Zhou, Ishwar Parhar
    Journal of Experimental & Clinical Cancer Research.2019;[Epub]     CrossRef
  • Postoperative adjuvant chemotherapy is associated with a lower incidence of colorectal adenomas in patients with previous colorectal cancer
    Hee Seung Lee, Sung Bae Kim, Hyun Jung Lee, Soo Jung Park, Sung Pil Hong, Jae Hee Cheon, Won Ho Kim, Tae Il Kim
    Gastrointestinal Endoscopy.2018; 87(3): 688.     CrossRef
  • Parameters of Glucose and Lipid Metabolism Affect the Occurrence of Colorectal Adenomas Detected by Surveillance Colonoscopies
    Nam Hee Kim, Jung Yul Suh, Jung Ho Park, Dong Il Park, Yong Kyun Cho, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
    Yonsei Medical Journal.2017; 58(2): 347.     CrossRef
  • Diabetes-induced mechanophysiological changes in the small intestine and colon
    Mirabella Zhao, Donghua Liao, Jingbo Zhao
    World Journal of Diabetes.2017; 8(6): 249.     CrossRef
  • Metformin use and the risk of colorectal adenoma: A systematic review and meta‐analysis
    Yoon Suk Jung, Chan Hyuk Park, Chang Soo Eun, Dong Il Park, Dong Soo Han
    Journal of Gastroenterology and Hepatology.2017; 32(5): 957.     CrossRef
  • Energy sensing pathways: Bridging type 2 diabetes and colorectal cancer?
    Juhong Yang, Reiko Nishihara, Xuehong Zhang, Shuji Ogino, Zhi Rong Qian
    Journal of Diabetes and its Complications.2017; 31(7): 1228.     CrossRef
  • Metformin therapy and the risk of colorectal adenoma in patients with type 2 diabetes: A meta-analysis
    Yi-Chao Hou, Qiang Hu, Jiao Huang, Jing-Yuan Fang, Hua Xiong
    Oncotarget.2017; 8(5): 8843.     CrossRef
  • Metformin therapy and risk of colorectal adenomas and colorectal cancer in type 2 diabetes mellitus patients: A systematic review and meta-analysis
    Feifei Liu, Lijing Yan, Zhan Wang, Yuanan Lu, Yuanyuan Chu, Xiangyu Li, Yisi Liu, Dongsheng Rui, Shaofa Nie, Hao Xiang
    Oncotarget.2017; 8(9): 16017.     CrossRef
  • Therapeutic strategies against cancer stem cells in human colorectal cancer (Review)
    Magdalena Szaryńska, Agata Olejniczak, Jarosław Kobiela, Piotr Spychalski, Zbigniew Kmieć
    Oncology Letters.2017;[Epub]     CrossRef
  • Potential Benefit of Metformin as Treatment for Colon Cancer: the Evidence so Far
    Azza Ali Abdelsatir, Nazik Elmalaika Husain, Abdallah Tarig Hassan, Wadie M Elmadhoun, Ahmed O Almobarak, Mohamed H Ahmed
    Asian Pacific Journal of Cancer Prevention.2016; 16(18): 8053.     CrossRef
  • Weight Change and Obesity Are Associated with a Risk of Adenoma Recurrence
    Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi
    Digestive Diseases and Sciences.2016; 61(9): 2694.     CrossRef
  • Associations between amount of smoking and alcohol intake and risk of colorectal neoplasm
    Yoon Suk Jung, Hwanseok Jung, Kyung Eun Yun, Seungho Ryu, Yoosoo Chang, Dong Il Park, Kyuyong Choi
    Journal of Gastroenterology and Hepatology.2016; 31(4): 788.     CrossRef
  • Metformin, Diabetes, and Survival among U.S. Veterans with Colorectal Cancer
    Jessica K. Paulus, Christina D. Williams, Furha I. Cossor, Michael J. Kelley, Robert E. Martell
    Cancer Epidemiology, Biomarkers & Prevention.2016; 25(10): 1418.     CrossRef
  • Inhibitory Effect of Metformin Therapy on the Incidence of Colorectal Advanced Adenomas in Patients With Diabetes
    Yo Han Kim, Ran Noh, Sun Young Cho, Seong Jun Park, Soung Min Jeon, Hyun Deok Shin, Suk Bae Kim, Jeong Eun Shin
    Intestinal Research.2015; 13(2): 145.     CrossRef
  • 6,331 View
  • 58 Download
  • 29 Web of Science
  • 25 Crossref
Close layer
Does Diabetes Mellitus Influence Standardized Uptake Values of Fluorodeoxyglucose Positron Emission Tomography in Colorectal Cancer?
Da Yeon Oh, Ji Won Kim, Seong-Joon Koh, Mingoo Kim, Ji Hoon Park, Su Yeon Cho, Byeong Gwan Kim, Kook Lae Lee, Jong Pil Im
Intest Res 2014;12(2):146-152.   Published online April 29, 2014
DOI: https://doi.org/10.5217/ir.2014.12.2.146
AbstractAbstract PDFPubReader
<b>Background/Aims</b><br/>

Hyperglycemia is associated with decreased 2-18[F]fluoro-2-deoxy-D-glucose (FDG) uptake by tumors assessed by positron emission tomography (PET). In this retrospective study we investigated a comparison of standardized uptake values (SUVs) in patients with primary colorectal cancers who either had diabetes mellitus (DM) or were otherwise healthy.

Methods

The medical records of 397 patients who were diagnosed with colorectal cancer and underwent PET-CT between January 2006 and December 2012 were analyzed. Eighty patients with DM and 317 patients without DM were included. Clinical characteristics were reviewed and maximal standardized uptake values (SUVmax) were calculated in the primary colorectal lesions.

Results

There was no significant difference between tumor SUVmax in DM patients (10.60±5.78) and those without DM (10.92±5.44). In addition, no significant difference was detected between tumor SUVmax in DM patients with glycated hemoglobin (HbA1c) levels <8% (10.34±5.17) and those with HbA1c levels ≥8% (10.61±7.27). The maximum size of the primary colorectal tumor was associated with SUVmax in a linear regression analysis.

Conclusion

The results of this study showed that DM did not influence FDG uptake values in colorectal cancer patients regardless of glucose levels.

Citations

Citations to this article as recorded by  
  • Effect of steroid treatment on the diagnostic yield of baseline 18f-fluorodeoxyglucose positron emission tomography in aggressive B cell lymphoma
    Karyn Revital Geiger, Oren Pasvolsky, Tamar Berger, Pia Raanani, Tzippy Shochat, Ronit Gurion, Tamer Anati, David Groshar, Anat Gafter-Gvili, Hanna Bernstine
    EJNMMI Research.2022;[Epub]     CrossRef
  • A computer model simulating human glucose absorption and metabolism in health and metabolic disease states
    Richard J. Naftalin
    F1000Research.2016; 5: 647.     CrossRef
  • 5,587 View
  • 48 Download
  • 2 Web of Science
  • 2 Crossref
Close layer
Case Reports
Peritonsillar Involvement in Pyoderma Gangrenosum associated with Ulcerative Colitis
Yu Mi Byeon, Jun Lee, Sang Jun Lee, Chol Jin Park, Na Ra Yun, Young Dae Kim, Chan Guk Park, Man Woo Kim
Intest Res 2014;12(2):153-156.   Published online April 29, 2014
DOI: https://doi.org/10.5217/ir.2014.12.2.153
AbstractAbstract PDFPubReader

Peritonsillar abscess is a common deep throat infection. Early diagnosis and prompt, appropriate management of a peritonsillar abscess prevents mortality. A 45-year-old woman on steroids for an ulcerative colitis (UC) exacerbation presented with sore throat and multiple skin ulcers on her left forearm and right foot. Computed tomography of the neck revealed a peritonsillar abscess. Gram staining and culture of the abscess were negative, and a skin biopsy suggested pyoderma gangrenosum (PG). The final diagnosis was peritonsillar involvement of steroid-refractory PG-associated UC. The patient showed a complete response to infliximab. Here, we report a case of successful infliximab treatment for peritonsillar involvement of steroid-refractory PG-associated UC.

Citations

Citations to this article as recorded by  
  • Biologic and small-molecule medications in the management of pyoderma gangrenosum
    Fatima McKenzie, Devin Cash, Angela Gupta, Laurel W. Cummings, Alex G. Ortega-Loayza
    Journal of Dermatological Treatment.2019; 30(3): 264.     CrossRef
  • Pyoderma gangrenosum and tumour necrosis factor alpha inhibitors: A semi‐systematic review
    Hakim Ben Abdallah, Karsten Fogh, Rikke Bech
    International Wound Journal.2019; 16(2): 511.     CrossRef
  • Efficacy of cytapheresis for remission induction and dermatological manifestations of ulcerative colitis
    Osamu Nomura, Taro Osada, Tomoyoshi Shibuya, Dai Ishikawa, Keiichi Haga, Tomohiro Kodani, Naoto Sakamoto, Tatsuo Ogihara, Ken Yamaji, Sumio Watanabe
    Journal of Clinical Apheresis.2018; 33(1): 21.     CrossRef
  • Multiple Pyoderma Gangrenosum in Ulcerative Colitis
    Sung Bum Kim, Si Hyung Lee
    The Korean Journal of Gastroenterology.2018; 72(3): 155.     CrossRef
  • Factors Associated with Anxiety and Depression in Korean Patients with Inactive Inflammatory Bowel Disease
    Min Chul Kim, Yoon Suk Jung, Young Seok Song, Jung In Lee, Jung Ho Park, Chong Il Sohn, Kyu Yong Choi, Dong Il Park
    Gut and Liver.2016;[Epub]     CrossRef
  • 4,884 View
  • 48 Download
  • 5 Web of Science
  • 5 Crossref
Close layer
Superior Mesenteric Vein Thrombosis as an Early Presentation of Myelodysplastic Syndrome: A Case Report
Min Jung Kim, Hyun Joo Song, Woo Kun Kim, Sun Hyung Kim
Intest Res 2014;12(2):157-161.   Published online April 29, 2014
DOI: https://doi.org/10.5217/ir.2014.12.2.157
AbstractAbstract PDFPubReader

Mesenteric venous thrombosis (MVT) is a serious condition due to its potential association with mesenteric ischemia and infarction of the small bowel. Symptoms of MVT are often vague, making accurate diagnosis and sufficient treatment difficult. However, increased awareness and new imaging modalities for this condition have improved outcomes for patients with MVT. Treatment includes anticoagulation, transcatheter therapy, and surgery. In the present report, we describe the case study of a 62-year-old woman with a presenting diagnosis of superior MVT, who was finally diagnosed with myelodysplastic syndrome. The superior MVT spontaneously dissolved after the patient underwent 6 months of systemic anticoagulation therapy. Invasive surgery or bowel resection was not required.

Citations

Citations to this article as recorded by  
  • A Case of Malignant Lymphoma Discovered During Treatment of Superior Mesenteric Vein Thrombosis
    Haruka Oi, Satoshi Yamamoto, Takafumi Akai, Masako Ogawa, Yukiyoshi Masaki
    Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons).2017; 42(6): 1013.     CrossRef
  • Acute Myocardial Infarction Caused by Thrombotic Microangiopathy Complicated With Myelodysplastic Syndrome
    Tsukasa Oshima, Masayasu Ikutomi, Hiroki Shinohara, Jumpei Ishiwata, Keiko Fukino, Toshihiro Amaki, Fumitaka Nakamura
    International Heart Journal.2016; 57(5): 634.     CrossRef
  • 5,370 View
  • 55 Download
  • 1 Web of Science
  • 2 Crossref
Close layer
A Case of Ascending Colonic Xanthoma Presenting as a Lateral Spreading Tumor
Sang Hun Kim, Hyun Soo Kim, Yoo Duk Choi, Won Suk Choi, Ban Seok Kim, Seon Young Park, Sung Bum Cho, Chang Hwan Park, Young Eun Joo, Sung Kyu Choi, Jong Sun Rew
Intest Res 2014;12(2):162-165.   Published online April 29, 2014
DOI: https://doi.org/10.5217/ir.2014.12.2.162
AbstractAbstract PDFPubReader

Gastrointestinal xanthomas are characterized by foamy cytoplasmic cells containing lipid in lamina propria, and occur almost in the gastric mucosa. Colonic xanthomas have been described in rare case. All reported colonic xanthomas were located in rectosigmoid. Rectosigmoid xanthomas have tended to exhibit small polypoid lesion, on the contrary flat in stomach. We report a case of xanthoma on ascending colon presenting as a laterally spreading tumor resected by endoscopic mucosal resection method.

Citations

Citations to this article as recorded by  
  • Tubular Adenoma Arising Within a Rectosigmoid Xanthoma: A Case Report
    Kaley Coffey, Heather L Mateja, William Bowers, Peter DeVito
    Cureus.2024;[Epub]     CrossRef
  • Adenoma arising from xanthoma in the transverse colon: a case report
    Yu Jin Jung, Jun Lee, Seong Jung Kim, Ran Hong
    Gastroenterology Report.2022;[Epub]     CrossRef
  • XANTHELASMAS OF THE UPPER GASTROINTESTINAL TRACT: A REPORT OF FOUR CASES
    Devojee M, Rajeshwari G, Jagan Mohan Rao K, Akarsh M P
    Journal of Evidence Based Medicine and Healthcare.2015; 2(18): 2781.     CrossRef
  • 13,007 View
  • 61 Download
  • 2 Web of Science
  • 3 Crossref
Close layer
Images of the Issue
A Patient with Recurrent Abdominal Pain and Intestinal Obstruction
Jung Wan Han, Hyun Joo Jang
Intest Res 2014;12(2):166-168.   Published online April 29, 2014
DOI: https://doi.org/10.5217/ir.2014.12.2.166
PDFPubReader
  • 5,455 View
  • 45 Download
Close layer
Letterses to the Editor
Interval Cancers after a Negative Colonoscopy Finding in a Korean Population: A Small Step for Gastroenterologists but One Giant Leap for Koreans
Jae Myung Cha
Intest Res 2014;12(2):169-170.   Published online April 29, 2014
DOI: https://doi.org/10.5217/ir.2014.12.2.169
PDFPubReader

Citations

Citations to this article as recorded by  
  • Miss rate of colorectal neoplastic polyps and risk factors for missed polyps in consecutive colonoscopies
    Nam Hee Kim, Yoon Suk Jung, Woo Shin Jeong, Hyo-Joon Yang, Soo-Kyung Park, Kyuyong Choi, Dong Il Park
    Intestinal Research.2017; 15(3): 411.     CrossRef
  • Author's Reply
    Dong Il Park
    Intestinal Research.2014; 12(2): 171.     CrossRef
  • 9,785 View
  • 62 Download
  • 1 Web of Science
  • 2 Crossref
Close layer
Author's Reply
Dong Il Park
Intest Res 2014;12(2):171-171.   Published online April 29, 2014
DOI: https://doi.org/10.5217/ir.2014.12.2.171
PDFPubReader
  • 9,553 View
  • 37 Download
Close layer

Intest Res : Intestinal Research
Close layer
TOP