Inflammatory bowel disease (IBD) is a chronic idiopathic inflammatory condition with intestinal and extraintestinal manifestations. Medications are the cornerstone of treatment of IBD. However, patients often adhere to medication poorly. Adherence to medications is defined as the process by which patients take their medications as prescribed. Treatment non-adherence is a common problem among chronic diseases, averaging 50% in developed countries and is even poorer in developing countries. In this review, we will examine the adherence data in IBD which vary greatly depending on the study population, route of administration, and methods of adherence measurement used. We will also discuss the adverse clinical outcomes related to non-adherence to medical treatment including increased disease activity, flares, loss of response to anti-tumor necrosis factor therapy, and so forth. There are many methods to measure medication adherence namely direct and indirect methods, each with their advantages and drawbacks. Finally, we will explore different intervention strategies to improve adherence to medications.

Citations

Citations to this article as recorded by  

• Despite Increased Disease Activity, Women who Attended a Dedicated Inflammatory Bowel Disease and Pregnancy Clinic Had Infants With Higher Apgar Scores: A Population-Based Study
  Sangmin Lee, Cynthia H Seow, Kara Nerenberg, Stefania Bertazzon, Yvette Leung, Vivian Huang, Tara Whitten, Stephanie Coward, Remo Panaccione, Gilaad G Kaplan, Amy Metcalfe
  Inflammatory Bowel Diseases.2024; 30(7): 1071.     CrossRef
• Knowledge in Inflammatory Bowel Disease: Translation to Portuguese, Validation, and Clinical Application of the IBD-KNOW Questionnaire
  Cristiana Sequeira, Mariana Coelho, Inês Costa Santos, Sara Ramos Lopes, Cristina Teixeira, João Mangualde, Isabelle Cremers, Ana Paula Oliveira
  GE - Portuguese Journal of Gastroenterology.2024; 31(4): 246.     CrossRef
• Effectiveness of Single-Tablet Combination Therapy in Improving Adherence and Persistence and the Relation to Clinical and Economic Outcomes
  Carly J. Paoli, Jörg Linder, Khushboo Gurjar, Deepika Thakur, Julie Wyckmans, Stacy Grieve
  Journal of Health Economics and Outcomes Research.2024;[Epub]     CrossRef
• Effectiveness of Single-Tablet Combination Therapy in Improving Adherence and Persistence and the Relation to Clinical and Economic Outcomes
  Carly Paoli, Jörg Linder, Khushboo Gurjar, Deepika Thakur, Julie Wyckmans, Stacy Grieve
  Journal of Health Economics and Outcomes Research.2024; : 8.     CrossRef
• Inflammatory bowel disease (IBD) patients with impaired quality of life on biologic therapy benefit from the support of an IBD nurse specialist: Results of a randomised controlled trial in Germany (IBDBIO‐ASSIST study)
  Bernd Bokemeyer, Sandra Plachta‐Danielzik, Isa Maria Steiner, Daniela Pohlschneider, Eugen Urzica, Petra Hartmann, Jennifer Zemke, Ulrich Tappe, Stefan Schreiber, Nadine Steinkat, Jana Langbrandtner, Angelika Hüppe, Tom Stargardt
  Alimentary Pharmacology & Therapeutics.2024; 59(9): 1082.     CrossRef
• How can we improve the carbon footprint of IBD clinical care?
  Isabel Carbery, Gauraang Bhatnagar, Rachel Cooney, Christian Selinger
  Frontline Gastroenterology.2024; 15(e1): e55.     CrossRef
• Unmet needs of drugs for irritable bowel syndrome and inflammatory bowel diseases: interest of vagus nerve stimulation and hypnosis
  Bruno Bonaz
  Inflammopharmacology.2024; 32(2): 1005.     CrossRef
• High refill-adherence to adalimumab is associated with low disease activity in patients with inflammatory bowel disease
  Esma H. San, Angelique Egberts, Caroline W. Th. van Dijck - van Boetzelaer, Rachel L. West, Erwin C. Vasbinder
  European Journal of Clinical Pharmacology.2024; 80(7): 1089.     CrossRef
• Improving Medication Adherence Levels in Inflammatory Bowel Disease (IBD) Patients: A Narrative Evidence-Based Review
  Obreniokibo Amiesimaka, Kristina Aluzaite, Rhiannon Braund, Michael Schultz
  Patient Preference and Adherence.2024; Volume 18: 905.     CrossRef
• Satisfaction With and Adherence to Off-Label Corticosteroids in Adolescents and Adults With Eosinophilic Esophagitis
  Benjamin D. Gold, Bridgett Goodwin, Kimberly Davis, Carolyn Sweeney, Ryan Ziemiecki, Jeanne Jiang, Tao Fan, Mena Boules, Szu-Ta Chen, David A. Katzka
  Journal of Clinical Gastroenterology.2024;[Epub]     CrossRef
• How the Western Diet Thwarts the Epigenetic Efforts of Gut Microbes in Ulcerative Colitis and Its Association with Colorectal Cancer
  Avisek Majumder, Shabana Bano
  Biomolecules.2024; 14(6): 633.     CrossRef
• Exploring the foundations of a digital health information service for patients with inflammatory bowel disease: a mixed method study in Gravitate-Health
  Sigurd Maurud, Lene Lunde, Anne Moen, Randi Opheim
  BMC Gastroenterology.2024;[Epub]     CrossRef
• Influence of multidisciplinary team care with abundant nurse staffing on patient-reported outcomes among patients with inflammatory bowel disease in clinical remission
  Makoto Tanaka, Aki Kawakami, Kayoko Sakagami, Tomoko Terai, Hiroaki ito
  Health and Quality of Life Outcomes.2024;[Epub]     CrossRef
• Motivational Interviewing as a Strategy to Improve Adherence in IBD Treatment: An Integrative Review Amidst COVID-19 Disruptions
  Caterina Mercuri, Maria Catone, Vincenzo Bosco, Assunta Guillari, Teresa Rea, Patrizia Doldo, Silvio Simeone
  Healthcare.2024; 12(12): 1210.     CrossRef
• Effect of Curcumin Plus Piperine on Redox Imbalance, Fecal Calprotectin and Cytokine Levels in Inflammatory Bowel Disease Patients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
  Amylly Sanuelly da Paz Martins, Orlando Roberto Pimentel de Araújo, Amanda da Silva Gomes, Fernanda Lívia Cavalcante Araujo, José Oliveira Junior, Joice Kelly Gomes de Vasconcelos, José Israel Rodrigues Junior, Islany Thaissa Cerqueira, Manoel Álvaro de F
  Pharmaceuticals.2024; 17(7): 849.     CrossRef
• What aspects do we overlook in the rehabilitation of patients with inflammatory bowel disease?
  Benil Nesli Ata, Sibel Eyigor
  World Journal of Gastroenterology.2024; 30(27): 3268.     CrossRef
• Fournier's Gangrene Associated With Untreated Crohn’s Disease in a Male Patient: A Case Report and Review of the Literature
  Nicos Kritharides, Marios Fouzas, Afroditi Stoupa, Spyridoula Sakkoula, Loukia Prounia - Alexopoulou, Georgios Rallis, Aikaterini Leventi
  Cureus.2024;[Epub]     CrossRef
• Psychological Factors Associated With Adherence to Oral Treatment in Ulcerative Colitis
  Sonya S Dasharathy, Millie D Long, Jeffrey M Lackner, Dana Ben-Ami Shor, Liu Yang, Nir Bar, Christina Ha, Guy A Weiss
  Inflammatory Bowel Diseases.2023; 29(1): 97.     CrossRef
• Development of an Inflammatory Bowel Disease-Specific Medication Adherence Instrument and Reasons for Non-adherence
  Erica J. Brenner, Millie D. Long, Michael D. Kappelman, Xian Zhang, Robert S. Sandler, Edward L. Barnes
  Digestive Diseases and Sciences.2023; 68(1): 58.     CrossRef
• Impact of a pharmacist‐led thiopurine monitoring service in outpatients with inflammatory bowel disease
  Sheridan E. Rodda, Karina J. Fildes, Edward Shelton, Rimma Goldberg, Gregory T. Moore
  Internal Medicine Journal.2023; 53(5): 779.     CrossRef
• Modulating the Microbiome for Crohn’s Disease Treatment
  Rachael Gowen, Ahmed Gamal, Luca Di Martino, Thomas S. McCormick, Mahmoud A. Ghannoum
  Gastroenterology.2023; 164(5): 828.     CrossRef
• The level of adherence to best-practice guidelines by interprofessional teams with and without acute care nurse practitioners in cardiac surgery: A study protocol
  Li-Anne Audet, Mélanie Lavoie-Tremblay, Éric Tchouaket, Kelley Kilpatrick, Robert Jeenchen Chen
  PLOS ONE.2023; 18(3): e0282467.     CrossRef
• Identification of inadequate responders to advanced therapy among commercially-insured adult patients with Crohn’s disease and ulcerative colitis in the United States
  Theresa Hunter Gibble, April N. Naegeli, Michael Grabner, Keith Isenberg, Mingyang Shan, Chia-Chen Teng, Jeffrey R. Curtis
  BMC Gastroenterology.2023;[Epub]     CrossRef
• Update on the role of upadacitinib in the treatment of adults with moderately to severely active ulcerative colitis
  Kenneth Ernest-Suarez, Remo Panaccione
  Therapeutic Advances in Gastroenterology.2023; 16: 175628482311582.     CrossRef
• Efficacy, Safety, Patient Experience, and Tolerability of Risankizumab Administered by On-Body Injector for Moderate to Severe Crohn’s Disease
  Edward V. Loftus, Jenny Griffith, Ezequiel Neimark, Alexandra Song, Kori Wallace, Sujani Nannapaneni, Ji Zhou, Rachel Byrne, Kristina Kligys, Yinuo Pang, Xiaomei Liao, Jasmina Kalabic, Marla Dubinsky
  Advances in Therapy.2023; 40(5): 2311.     CrossRef
• Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems
  Tsvetelina H. Baryakova, Brett H. Pogostin, Robert Langer, Kevin J. McHugh
  Nature Reviews Drug Discovery.2023; 22(5): 387.     CrossRef
• Selective JAK1 inhibitors for the treatment of inflammatory bowel disease
  Ole Haagen Nielsen, Theresa Louise Boye, John Gubatan, Deepavali Chakravarti, James B. Jaquith, Eric C. LaCasse
  Pharmacology & Therapeutics.2023; 245: 108402.     CrossRef
• Health Communication Research Informs Inflammatory Bowel Disease Practice and Research: A Narrative Review
  Neda Karimi, Alison Rotha Moore, Annabelle Lukin, Susan J Connor
  Crohn's & Colitis 360.2023;[Epub]     CrossRef
• Medication Adherence Rates in Adolescents With Eosinophilic Esophagitis Are Low and Are Associated With Health Habits
  Pooja Mehta, Zhaoxing Pan, Wenru Zhou, Bethany M. Kwan, Glenn T. Furuta
  Journal of Pediatric Gastroenterology & Nutrition.2023; 77(4): 532.     CrossRef
• “It's just like putting your socks on”: patients' perspectives on inflammatory bowel disease medication adherence
  Obreniokibo Ibifubara Amiesimaka, Kristina Aluzaite, Rhiannon Braund, Michael Schultz
  Exploratory Research in Clinical and Social Pharmacy.2023; 12: 100385.     CrossRef
• Non-invasive vagus nerve stimulation: the future of inflammatory bowel disease treatment?
  Bruno Bonaz
  Bioelectronic Medicine.2023;[Epub]     CrossRef
• What Do We Know about Medication Adherence Interventions in Inflammatory Bowel Disease, Multiple Sclerosis and Rheumatoid Arthritis? A Scoping Review of Randomised Controlled Trials
  Kathryn King, Serena McGuinness, Natalie Watson, Christine Norton, Trudie Chalder, Wladyslawa Czuber-Dochan
  Patient Preference and Adherence.2023; Volume 17: 3265.     CrossRef
• Understanding Medication Nonadherence in Crohn’s Disease Patients: A Qualitative Evaluation
  Robert E Brady, Jessica K Salwen-Deremer, Natalie C Tunnell, Michael W Winter
  Inflammatory Bowel Diseases.2023;[Epub]     CrossRef
• Impact of an intervention program on drug adherence in patients with ulcerative colitis: Randomized clinical trial
  Mila Pacheco, Pedro Sá, Gláucia Santos, Ney Boa-Sorte, Kilma Domingues, Larissa Assis, Marina Silva, Ana Oliveira, Daniel Santos, Jamile Ferreira, Rosemeire Fernandes, Flora Fortes, Raquel Rocha, Genoile Santana, Wan-Long Chuang
  PLOS ONE.2023; 18(12): e0295832.     CrossRef
• Interventions to improve medication adherence in inflammatory bowel disease: A systematic review
  Shrey Gohil, Zahra Majd, Jared C. Sheneman, Susan M. Abughosh
  Patient Education and Counseling.2022; 105(7): 1731.     CrossRef
• Assessing the repercussions of COVID-19 pandemic on symptoms, disease management, and emotional well-being in patients with inflammatory bowel disease: a multi-site survey study
  Mohammed El-Dallal, Ariana Saroufim, Hannah Systrom, Sarah Ballou, Adel Farhoud, Ravi Teja Pasam, Salini Samyuktha Gadupudi, Karim Osman, Khadija Chaudrey, Adam Cheifetz, Joseph D. Feuerstein
  Scandinavian Journal of Gastroenterology.2022; 57(4): 406.     CrossRef
• Health Confidence Is Associated With Disease Outcomes and Health Care Utilization in Inflammatory Bowel Disease: A Nationwide Cross-sectional Study
  Chung Sang Tse, Corey A Siegel, S Alandra Weaver, Brant J Oliver, Catherine Bresee, Welmoed K van Deen, Gil Y Melmed
  Inflammatory Bowel Diseases.2022; 28(10): 1565.     CrossRef
• Impact of PEGylation on an antibody-loaded nanoparticle-based drug delivery system for the treatment of inflammatory bowel disease
  Neha Shrestha, Yining Xu, Julien R.C. Prévost, Fiona McCartney, David Brayden, Raphaël Frédérick, Ana Beloqui, Véronique Préat
  Acta Biomaterialia.2022; 140: 561.     CrossRef
• Stopping Anti-TNF in Crohn’s Disease Remitters: Pros and Cons: The Pros
  Edouard Louis
  Inflammatory Intestinal Diseases.2022; 7(1): 64.     CrossRef
• Factors associated with poor compliance amongst hospitalized, predominantly adolescent pediatric Crohn’s disease patients
  Nathaniel A. Cohen, Dejan M. Micic, Atsushi Sakuraba
  Annals of Medicine.2022; 54(1): 886.     CrossRef
• Proactive infliximab optimisation using a pharmacokinetic dashboard versus standard of care in patients with Crohn’s disease: study protocol for a randomised, controlled, multicentre, open-label study (the OPTIMIZE trial)
  Konstantinos Papamichael, Vipul Jairath, Guangyong Zou, Benjamin Cohen, Timothy Ritter, Bruce Sands, Corey Siegel, John Valentine, Michelle Smith, Niels Vande Casteele, Marla Dubinsky, Adam Cheifetz
  BMJ Open.2022; 12(4): e057656.     CrossRef
• Medication Adherence and Its Influencing Factors Among Inflammatory Bowel Disease Patients in China
  Fen Xu, Juping Tang, Zhiping Zhu, Yan Chen, Wen Hu, Sha Lu, Yunxian Zhou, Ding Lin
  International Journal of General Medicine.2022; Volume 15: 4141.     CrossRef
• Treatment persistence and maintenance dose titration among ulcerative colitis patients on biologics: a pooled study of three United States claim databases
  Janvi Sah, Amanda Teeple, Erik Muser, Cynthia Gutierrez, Themistocles Dassopoulos
  Current Medical Research and Opinion.2022; 38(7): 1093.     CrossRef
• Psychological Effects and Medication Adherence among Korean Patients with Inflammatory Bowel Disease during the Coronavirus Disease 2019 Pandemic: A Single-Center Survey
  Ji Eun Ryu, Sung-Goo Kang, Sung Hoon Jung, Shin Hee Lee, Sang-Bum Kang
  Journal of Clinical Medicine.2022; 11(11): 3034.     CrossRef
• Factors influencing poor medication adherence amongst patients with chronic disease in low-and-middle-income countries: A systematic scoping review
  Gloria Dunisani Chauke, Olivia Nakwafila, Buyisile Chibi, Benn Sartorius, Tivani Mashamba-Thompson
  Heliyon.2022; 8(6): e09716.     CrossRef
• Rational Design of Self-Emulsifying Pellet Formulation of Thymol: Technology Development Guided by Molecular-Level Structure Characterization and Ex Vivo Testing
  Jan Macku, Katerina Kubova, Martina Urbanova, Jan Muselik, Ales Franc, Gabriela Koutna, Miroslava Pavelkova, David Vetchy, Josef Masek, Eliska Maskova, Jiri Brus
  Pharmaceutics.2022; 14(8): 1545.     CrossRef
• Poor Adherence to Medical and Dietary Treatments in Adult Patients With Eosinophilic Esophagitis
  Maria L. Haasnoot, Salma Safi, Albert J. Bredenoord
  American Journal of Gastroenterology.2022; 117(9): 1412.     CrossRef
• Improvement in Medication Adherence after Pharmacist Intervention Is Associated with Favorable Clinical Outcomes in Patients with Ulcerative Colitis
  Jae Song Kim, Min Jung Geum, Eun Sun Son, Yun Mi Yu, Jae Hee Cheon, Kyeng Hee Kwon
  Gut and Liver.2022; 16(5): 736.     CrossRef
• Qualitative Interviews to Support Development and Cognitive Debriefing of the Adelphi Adherence Questionnaire (ADAQ©): A Patient-Reported Measure of Medication Adherence Developed for Use in a Range of Diseases, Treatment Modalities, and Countries
  Sarah Bentley, Lucy Morgan, Elizabeth Exall, Rob Arbuckle, Rebecca C Rossom, Nicholas Roche, Kamlesh Khunti, Victoria Higgins, James Piercy
  Patient Preference and Adherence.2022; Volume 16: 2579.     CrossRef
• Electrical neuromodulation therapy for inflammatory bowel disease
  Farah Yasmin, Abdul Moiz Sahito, Syeda Lamiya Mir, Govinda Khatri, Somina Shaikh, Ambresha Gul, Syed Adeel Hassan, Thoyaja Koritala, Salim Surani
  World Journal of Gastrointestinal Pathophysiology.2022; 13(5): 128.     CrossRef
• Mobile Apps for the Management of Gastrointestinal Diseases: Systematic Search and Evaluation Within App Stores
  Eva-Maria Messner, Niklas Sturm, Yannik Terhorst, Lasse B Sander, Dana Schultchen, Alexandra Portenhauser, Simone Schmidbaur, Michael Stach, Jochen Klaus, Harald Baumeister, Benjamin M Walter
  Journal of Medical Internet Research.2022; 24(10): e37497.     CrossRef
• A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and Persistence With Inflammatory Bowel Disease Therapy (ASSIST Study): Protocol for a Randomized Controlled Trial
  Jordan Axelrad, Millie Long, Sara Horst, Anita Afzali, Tamar Sapir, Kristina Fajardo, Kara De Felice, Robert Sandler, Raymond Cross
  JMIR Research Protocols.2022; 11(12): e40382.     CrossRef
• Medication adherence in women with IBD of childbearing age likely associated with disease knowledge
  Robyn Laube, Christian Selinger, Rupert W. Leong
  Therapeutic Advances in Gastroenterology.2022; 15: 175628482211440.     CrossRef
• Racial or ethnic differences on treatment adherence and persistence among patients with inflammatory bowel diseases initiated with biologic therapies
  Qian Cai, Zhijie Ding, Alex Z. Fu, Aarti A. Patel
  BMC Gastroenterology.2022;[Epub]     CrossRef
• Adherence to glaucoma medication, illness perceptions, and beliefs about glaucoma: Attitudinal perspectives among Turkish population
  Soner Guven, Mehmet Talay Koylu, Tarkan Mumcuoglu
  European Journal of Ophthalmology.2021; 31(2): 469.     CrossRef
• Utility of the MARS-5 in Assessing Medication Adherence in IBD
  James K Stone, Leigh Anne Shafer, Lesley A Graff, Lisa Lix, Kelcie Witges, Laura E Targownik, Clove Haviva, Kathryn Sexton, Charles N Bernstein
  Inflammatory Bowel Diseases.2021; 27(3): 317.     CrossRef
• Curcumin and inflammatory bowel diseases: From in vitro studies to clinical trials
  Farzaneh Fallahi, Sarina Borran, Milad Ashrafizadeh, Ali Zarrabi, Mohammad Hossein Pourhanifeh, Mahmood Khaksary Mahabady, Amirhossein Sahebkar, Hamed Mirzaei
  Molecular Immunology.2021; 130: 20.     CrossRef
• Infection risk in sarcoidosis patients treated with methotrexate compared to azathioprine: A retrospective ‘target trial’ emulated with Swedish real‐world data
  Marios Rossides, Susanna Kullberg, Daniela Di Giuseppe, Anders Eklund, Johan Grunewald, Johan Askling, Elizabeth V. Arkema
  Respirology.2021; 26(5): 452.     CrossRef
• Adherence to Subcutaneous Biological Therapies in Patients with Inflammatory Rheumatic Diseases and Inflammatory Bowel Disease: A Systematic Review
  Juan C Nieto, Claudia Arajol, Loreto Carmona, Carlos Marras, Luis Cea-Calvo
  Immunotherapy.2021; 13(5): 433.     CrossRef
• Digital Medication Adherence Support: Could Healthcare Providers Recommend Mobile Health Apps?
  Claudine Backes, Carla Moyano, Camille Rimaud, Christine Bienvenu, Marie P. Schneider
  Frontiers in Medical Technology.2021;[Epub]     CrossRef
• Therapeutic Potential of Vagus Nerve Stimulation for Inflammatory Bowel Diseases
  Bruno Bonaz, Valérie Sinniger, Sonia Pellissier
  Frontiers in Neuroscience.2021;[Epub]     CrossRef
• Researching Interventions to Improve Medication Adherence in Ulcerative Colitis Patients
  Mila Palma Pacheco, Flora Maria Lorenzo Fortes, Raquel Rocha dos Santos, Genoile Oliveira Santana Silva
  Journal of Coloproctology.2021; 41(01): 096.     CrossRef
• JAK1 inhibition and inflammatory bowel disease
  Clare Harris, J R Fraser Cummings
  Rheumatology.2021; 60(Supplement): ii45.     CrossRef
• Effect of point‐of‐care gastrointestinal ultrasound on decision‐making and management in inflammatory bowel disease
  Antony B. Friedman, Anil Asthana, Simon R. Knowles, Aphra Robbins, Peter R. Gibson
  Alimentary Pharmacology & Therapeutics.2021; 54(5): 652.     CrossRef
• Factors Associated with Medication Non-Adherence in Patients with Dyslipidemia
  Eman Alefishat, Anan S. Jarab, Walid Al-Qerem, Lina Abu-Zaytoun
  Healthcare.2021; 9(7): 813.     CrossRef
• Systematic review with meta‐analysis: dietary intake in adults with inflammatory bowel disease
  Kelly Lambert, Daniel Pappas, Chiara Miglioretto, Arefeh Javadpour, Hannah Reveley, Laura Frank, Michael C. Grimm, Dorit Samocha‐Bonet, Georgina L. Hold
  Alimentary Pharmacology & Therapeutics.2021; 54(6): 742.     CrossRef
• Patients’ perspectives on medication for inflammatory bowel disease: a mixed-method systematic review
  José Diego Marques Santos, Juan Nicolás Peña-Sánchez, Sharyle A. Fowler
  European Journal of Gastroenterology & Hepatology.2021; 33(9): 1139.     CrossRef
• Adherence to treatment of patients with irritable bowel syndrome: state of the issue
  S.A. Sukhanova, A.Yu. Timakova, M.A. Livzan, M.M. Fedorin, Yu.P. Skirdenko, O.V. Gaus, K.A. Andreev, A.V. Gorbenko, M.I. Plinder
  Profilakticheskaya meditsina.2021; 24(8): 101.     CrossRef
• Adherence to Inflammatory Bowel Disease Medications in Southern New Zealand
  Kristina Aluzaite, Rhiannon Braund, Liam Seeley, Obreniokibo Ibifubara Amiesimaka, Michael Schultz
  Crohn's & Colitis 360.2021;[Epub]     CrossRef
• Impact of Demographic, Clinical and Psychosocial Variables on Drug Adherence and Outcomes in Indian Patients With Inflammatory Bowel Disease
  Rupa Banerjee, Partha Pal, Bhargavi Adigopula, Duvvuru Nageshwar Reddy
  Journal of Clinical Gastroenterology.2021; 55(10): e92.     CrossRef
• Living with Ulcerative Colitis in Japan: Biologic Persistence and Health-Care Resource Use
  Danielle Bargo, Theo Tritton, Joseph C. Cappelleri, Marco DiBonaventura, Timothy W. Smith, Takanori Tsuchiya, Sean Gardiner, Irene Modesto, Tim Holbrook, Daniel Bluff, Taku Kobayashi
  Inflammatory Intestinal Diseases.2021; 6(4): 186.     CrossRef
• Impact of pain associated with the subcutaneous administration of adalimumab
  Cristina Gely, Laura Marín, Jordi Gordillo, Míriam Mañosa, Federico Bertoletti, Fiorella Cañete, Carlos González-Muñoza, Margalida Calafat, Eugeni Domènech, Esther Garcia-Planella
  Gastroenterología y Hepatología.2020; 43(1): 9.     CrossRef
• Patient Perspectives on Short-Course Pharmacotherapy: Barriers and Facilitators to Medication Adherence
  LeeAnne B Sherwin, Diana Ross, Michelle Matteson-Kome, Matthew Bechtold, Chelsea Deroche, Bonnie Wakefield
  Journal of Patient Experience.2020; 7(5): 726.     CrossRef
• Pregnant women with IBD are more likely to be adherent to biologic therapies than other medications
  Sangmin Lee, Cynthia H. Seow, Kamala Adhikari, Amy Metcalfe
  Alimentary Pharmacology & Therapeutics.2020; 51(5): 544.     CrossRef
• Encuesta de adherencia al tratamiento en enfermedad inflamatoria intestinal. Estudio ENADEII
  Inmaculada Alonso-Abreu, Onofre Alarcón-Fernández, Marta Carrillo-Palau, Laura Ramos-López, Javier P. Gisbert, María Chaparro, Pilar Nos, Alejandro Jiménez, Enrique Quintero-Carrión
  Gastroenterología y Hepatología.2020; 43(6): 285.     CrossRef
• Impact of pain associated with the subcutaneous administration of adalimumab
  Cristina Gely, Laura Marín, Jordi Gordillo, Míriam Mañosa, Federico Bertoletti, Fiorella Cañete, Carlos González-Muñoza, Margalida Calafat, Eugeni Domènech, Esther Garcia-Planella
  Gastroenterología y Hepatología (English Edition).2020; 43(1): 9.     CrossRef
• Challenges and Approaches to Assessing Medication Adherence in Pediatric Inflammatory Bowel Diseases
  David H. Barker, Jason M. Shapiro, Debra Lobato, Elizabeth L. McQuaid, Neal S. Leleiko
  Journal of Pediatric Gastroenterology and Nutrition.2020; 70(6): 759.     CrossRef
• A 12‐month pilot study outcomes of vagus nerve stimulation in Crohn's disease
  Valérie Sinniger, Sonia Pellissier, Florence Fauvelle, Candice Trocmé, Dominique Hoffmann, Laurent Vercueil, Jean‐Luc Cracowski, Olivier David, Bruno Bonaz
  Neurogastroenterology & Motility.2020;[Epub]     CrossRef
• Survey of adherence to treatment in inflammatory bowel disease. ENADEII study
  Inmaculada Alonso-Abreu, Onofre Alarcón-Fernández, Marta Carrillo-Palau, Laura Ramos-López, Javier Pérez Gisbert, María Chaparro, Pilar Nos, Alejandro Jiménez, Enrique Quintero-Carrión
  Gastroenterología y Hepatología (English Edition).2020; 43(6): 285.     CrossRef
• Adherence to exclusive enteral nutrition by adults with active Crohn’s disease is associated with conscientiousness personality trait: a sub‐study
  C. L. Wall, A. McCombie, R. Mulder, A. S. Day, R. B. Gearry
  Journal of Human Nutrition and Dietetics.2020; 33(6): 752.     CrossRef
• Maytenus robusta Reissek, a medicinal plant popularly used to treat digestive diseases, promotes ameliorative effects in colon and liver of mice exposed to dextran sulfate sodium
  Mariéli Mees, Marianne Caroline Meurer, Luísa Nathalia Bolda Mariano, Thaise Boeing, Lincon Bordignon Somensi, Marihá Mariott, Rivaldo Niero, Valdir Cechinel-Filho, Sérgio Faloni de Andrade, Lucienir Pains Duarte, Grasiely Faria de Sousa, Priscila de Souz
  Journal of Ethnopharmacology.2020; : 113180.     CrossRef
• A Micro‐longitudinal Approach to Measuring Medication Adherence in Pediatric Inflammatory Bowel Diseases
  Jill M. Plevinsky, Lee A. Denson, Jenny Hellmann, Phillip Minar, Michael J. Rosen, Kevin A. Hommel
  Journal of Pediatric Gastroenterology and Nutrition.2020; 71(3): 366.     CrossRef
• Emulsifiers Impact Colonic Length in Mice and Emulsifier Restriction is Feasible in People with Crohn’s Disease
  Alicia M. Sandall, Selina R. Cox, James O. Lindsay, Andrew T. Gewirtz, Benoit Chassaing, Megan Rossi, Kevin Whelan
  Nutrients.2020; 12(9): 2827.     CrossRef
• Adherence to Medical Treatment in Inflammatory Bowel Disease Patients from a Referral Center in Bahia-Brazil
  Laíla D. Andrade, Fernanda A. Oliveira, Victor D. Mariano, Monique C. A. Santos, Fernanda A. Pereira, Cláudia I. N. dos Santos, Flora M. L. Fortes, Andrea M. Pimentel, Jaciane A. Mota, Neogélia P. Almeida, Valdiana C. Surlo, Bruno C. Silva, Mila P. Pachec
  BioMed Research International.2020; 2020: 1.     CrossRef
• A Role for Primary Care Pharmacists in the Management of Inflammatory Bowel Disease? Lessons from Chronic Disease: A Systematic Review
  Sharmila S. Prasad, Kerith Duncanson, Simon Keely, Nicholas J. Talley, Therése Kairuz, Gerald J. Holtmann, Ayesha Shah, Marjorie M. Walker
  Pharmacy.2020; 8(4): 204.     CrossRef
• Self-assessment of treatment targets in patients with inflammatory bowel disease using a survey
  Philipp A. Reuken, Philip C. Grunert, Andreas Lügering, Niels Teich, Andreas Stallmach
  Therapeutic Advances in Gastroenterology.2020; 13: 175628482097121.     CrossRef
• Longitudinal Barriers to Thiopurine Adherence in Adolescents With Inflammatory Bowel Diseases
  Jill M Plevinsky, Andrea A Wojtowicz, Steven A Miller, Rachel N Greenley
  Journal of Pediatric Psychology.2019; 44(1): 52.     CrossRef
• Adherence to Asacol once daily versus divided regimen for maintenance therapy in ulcerative colitis: a prospective, multicenter, randomized study
  Soo-Kyung Park, Sang Hyun Park, Chang Soo Eun, Geom Seog Seo, Jong Pil Im, Tae Oh Kim, Dong-Il Park
  Intestinal Research.2019; 17(3): 349.     CrossRef
• Nurse and Patient Perceptions and Preferences for Subcutaneous Autoinjectors for Inflammatory Joint or Bowel Disease: Findings from a European Survey
  Steve Fenwick, Kunal Thakur, Duncan Munro
  Rheumatology and Therapy.2019; 6(2): 195.     CrossRef
• Factors Associated with Adherence to Allergen Specific Subcutaneous Immunotherapy
  Ji-Ho Lee, So-Hee Lee, Ga-Young Ban, Young-Min Ye, Dong-Ho Nahm, Hae-Sim Park, Yoo Seob Shin
  Yonsei Medical Journal.2019; 60(6): 570.     CrossRef
• Self-Management Through Social Support Among Emerging Adults With Inflammatory Bowel Disease
  Kendra J. Kamp, Zhehui Luo, Amanda Holmstrom, Barbara Given, Gwen Wyatt
  Nursing Research.2019; 68(4): 285.     CrossRef
• Innovations in Oral Therapies for Inflammatory Bowel Disease
  Christopher Ma, Robert Battat, Parambir S. Dulai, Claire E. Parker, William J. Sandborn, Brian G. Feagan, Vipul Jairath
  Drugs.2019; 79(12): 1321.     CrossRef
• Longitudinal non‐adherence predicts treatment escalation in paediatric ulcerative colitis
  Julia K. Carmody, Jill Plevinsky, James L. Peugh, Lee A. Denson, Jeffrey S. Hyams, Debra Lobato, Neal S. LeLeiko, Kevin A. Hommel
  Alimentary Pharmacology & Therapeutics.2019; 50(8): 911.     CrossRef
• The Development of a Screening Tool to Identify and Classify Nonadherence in Inflammatory Bowel Disease
  Aria Zand, Audrey Nguyen, Zack Stokes, Welmoed van Deen, Courtney Reynolds, Magdalena Dimitrova, Ariela Khandadash, Miriam Dvorsky, Jenny Sauk, Eric Esrailian, Daniel Hommes
  Crohn's & Colitis 360.2019;[Epub]     CrossRef
• British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults
  Christopher Andrew Lamb, Nicholas A Kennedy, Tim Raine, Philip Anthony Hendy, Philip J Smith, Jimmy K Limdi, Bu’Hussain Hayee, Miranda C E Lomer, Gareth C Parkes, Christian Selinger, Kevin J Barrett, R Justin Davies, Cathy Bennett, Stuart Gittens, Malcolm
  Gut.2019; 68(Suppl 3): s1.     CrossRef
• Treatment of inflammatory bowel disease via green tea polyphenols: possible application and protective approaches
  Sajid Ur Rahman, Yu Li, Yingying Huang, Lei Zhu, Shibin Feng, Jinjie Wu, Xichun Wang
  Inflammopharmacology.2018; 26(2): 319.     CrossRef
• A RARE CASE OF CROHN DISEASE COMPLICATED WITH STEROID MONOTHERAPY-RELATED RETROPHARYNGEAL ABSCESS AND INITIALLY MISINTERPRETED PYODERMA GANGRENOSUM DEVELOPMENT
  Michael Doulberis, Jörg Dähn, Jannis Kountouras, Volker Maier, Arthur Helbling, Patrick Dubach
  Gastroenterology Nursing.2018; 41(4): 347.     CrossRef
• Clinical usefulness of remote patient monitoring using e-Health technologies in patients with inflammatory bowel diseases
  Sung Noh Hong
  The Korean Journal of Internal Medicine.2018; 33(5): 876.     CrossRef
• Is Curcumin a Possibility to Treat Inflammatory Bowel Diseases?
  Rafaela Mazieiro, Renata Reis Frizon, Sandra Maria Barbalho, Ricardo de Alvares Goulart
  Journal of Medicinal Food.2018; 21(11): 1077.     CrossRef
• Brazilian green propolis hydroalcoholic extract reduces colon damages caused by dextran sulfate sodium-induced colitis in mice
  Luisa Nathália Bolda Mariano, Caroline Arruda, Lincon Bordignon Somensi, Ana Paula Michels Costa, Eduardo Gnoatto Perondi, Thaise Boeing, Marihá Mariott, Rita de Cássia Melo Vilhena de Andr da Silva, Priscila de Souza, Jairo Kenupp Bastos, Sérgio Faloni d
  Inflammopharmacology.2018; 26(5): 1283.     CrossRef
• Medication non-adherence in inflammatory bowel diseases is associated with disability
  Jonathan Perry, Andy Chen, Viraj Kariyawasam, Glen Collins, Chee Choong, Wei Ling Teh, Nikola Mitrev, Friedbert Kohler, Rupert Wing Loong Leong
  Intestinal Research.2018; 16(4): 571.     CrossRef
• Adherence to therapy of patients with inflammatory bowel diseases
  A I Parfenov, A V Kagramanova, A F Babayan, O V Knyazev
  Terapevticheskii arkhiv.2018; 90(12): 4.     CrossRef

Non-steroidal anti-inflammatory drugs (NSAIDs) are well known to be associated with serious upper gastrointestinal complications, such as peptic ulcer, bleeding, perforation, and obstruction. Recently, attention has been mainly focused on the small bowel injuries caused by NSAIDs, and new endoscopic techniques such as capsule endoscopy and double balloon endoscopy can help in detecting such injuries. This article reviewed the epidemiology, pathogenesis, clinical manifestations, diagnosis, and treatment of small bowel injuries caused by NSAIDs. Small bowel injures by NSAIDs might occur with a similar frequency and extent as those observed in the upper gastrointestinal tract. The pathogenesis of NSAID-induced enteropathy is complex and not clearly understood. The various lesions observed in the small bowel, including petechiae, reddened folds, loss of villi, erosions, and ulcers can be detected by capsule endoscopy. A drug that could prevent or treat NSAID-induced enteropathy has not yet been developed. Therefore, further investigations should be performed to elucidate the pathogenesis of such enteropathy and develop suitable preventive and treatment strategies.

Citations

Citations to this article as recorded by  

• Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy
  Catalina Rojas-Solé, Víctor Pinilla-González, José Lillo-Moya, Tommy González-Fernández, Luciano Saso, Ramón Rodrigo
  Redox Report.2024;[Epub]     CrossRef
• Non-steroidal anti-inflammatory drug induced intestinal stricturing: diaphragm disease
  Nathan Johnson, Maseera Solkar, Rishabh Sehgal, Kallingal Riyad
  Journal of Surgical Case Reports.2024;[Epub]     CrossRef
• Jejunal Diverticulosis: An Atypical Lead Point for Small Bowel Volvulus
  Divij Agarwal, Iqbal Ali, Varun Shetty
  Cureus.2024;[Epub]     CrossRef
• Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: A cross-sectional study
  Wai Han Ng, Zalina Abu Zaid, Barakatun Nisak Mohd Yusof, Syafinaz Amin Nordin, Poh Ying Lim
  Cancer Treatment and Research Communications.2024; 39: 100813.     CrossRef
• Diagnosis of Small Intestinal Diaphragms and Strictures Induced by Non-steroidal Anti-inflammatory Drugs Through Intraoperative Enteroscopy: A Case Study From Saudi Arabia
  Rafaat M Chakik, Nasser I Alqahtani, Yahia Al-Hagawi, Saeed Nasser Alsharif, Abdullah S Alqahtani, Dawlah Hadi Asiri, Salihah Y Al-Mani
  Cureus.2024;[Epub]     CrossRef
• DA-9601 has protective effects comparable to those of proton pump inhibitor and rebamipide against nonsteroidal anti-inflammatory drugs-induced upper and lower gastrointestinal bleeding in patients with rheumatoid arthritis: A nationwide study using Korea
  Min Wook So, Aran Kim, Seung-Geun Lee
  Medicine.2024; 103(27): e38801.     CrossRef
• NSAID-Induced Lower Gastrointestinal Bleeding: A Case Report
  Mahmoud Nafie, Weeraput Chadbunchachai, Christo Lapa, Stephen Gregory, Joseph William Nunoo-Mensah
  World Journal of Colorectal Surgery.2024; 13(2): 49.     CrossRef
• Drugs Effective for Nonsteroidal Anti-inflammatory Drugs or Aspirin-induced Small Bowel Injuries
  Younghee Choe, Jae Myung Park, Joon Sung Kim, Yu Kyung Cho, Byung-Wook Kim, Myung-Gyu Choi, Na Jin Kim
  Journal of Clinical Gastroenterology.2024;[Epub]     CrossRef
• Massive Gastrointestinal Bleeding Related to NSAID Use in a Patient with Ileorectal Anastomosis
  Esere Nesiama, Letisha Mirembe, Kierra Weber, Sruthy Isaac, Deborah Trammell, Izi Obokhare, Andee Dzulkarnaen Zakaria
  Case Reports in Surgery.2024;[Epub]     CrossRef
• A Practical Index to Distinguish Backwash Ileitis From Crohn’s Terminal Ileitis in MR Enterography
  Bardia Khosravi, Aneseh Salehnia, Neda Pak, S Ali Montazeri, Ali Reza Sima, Homayoun Vahedi, Reza Malekzadeh, Amir Reza Radmard
  Inflammatory Bowel Diseases.2023; 29(1): 42.     CrossRef
• Toxic effects of naproxen on the intestine of the goldfish, Carassius auratus
  Jing Wang, Weijing Kong, Qianhang Sun, Xin Zheng, Shuping Wang, Zhenguang Yan
  Molecular & Cellular Toxicology.2023; 19(4): 667.     CrossRef
• Non-steroidal anti-inflammatory drugs (NSAIDs): A current insight into its molecular mechanism eliciting organ toxicities
  Nagesh Kishan Panchal, Evan Prince Sabina
  Food and Chemical Toxicology.2023; 172: 113598.     CrossRef
• Extract of Laurus nobilis attenuates inflammation and epithelial ulcerations in an experimental model of inflammatory bowel disease
  Natalie Correa, Robert Orlando
  WikiJournal of Medicine.2023; 10(1): 2.     CrossRef
• Nonsteroidal Anti-Inflammatory Drug-Induced Jejunal Ulcer Identified by Capsule Endoscopy
  Salman B. Syed, Ishaan Vohra, Sonu Dhillon, Omar S. Khokhar
  ACG Case Reports Journal.2023; 10(3): e00969.     CrossRef
• AINE, toxicidad gastrointestinal y enfermedad inflamatoria intestinal
  Gonzalo Hijos-Mallada, Carlos Sostres, Fernando Gomollón
  Gastroenterología y Hepatología.2022; 45(3): 215.     CrossRef
• Gastrointestinal and cardiovascular adverse events associated with NSAIDs
  María-José Domper Arnal, Gonzalo Hijos-Mallada, Angel Lanas
  Expert Opinion on Drug Safety.2022; 21(3): 373.     CrossRef
• Protection against indomethacin-induced loss of intestinal epithelial barrier function by a quercetin oxidation metabolite present in onion peel: In vitro and in vivo studies
  Jocelyn Fuentes, Oscar Brunser, Elías Atala, José Herranz, Adriano Costa de Camargo, Hermann Zbinden-Foncea, Hernán Speisky
  The Journal of Nutritional Biochemistry.2022; 100: 108886.     CrossRef
• Reducing Pain in Experimental Models of Intestinal Inflammation Affects the Immune Response
  Laura Golusda, Anja A Kühl, Britta Siegmund, Daniela Paclik
  Inflammatory Bowel Diseases.2022; 28(5): 801.     CrossRef
• Revisiting the Oxidation of Flavonoids: Loss, Conservation or Enhancement of Their Antioxidant Properties
  Hernan Speisky, Fereidoon Shahidi, Adriano Costa de Camargo, Jocelyn Fuentes
  Antioxidants.2022; 11(1): 133.     CrossRef
• Comprehensive Evaluation and Unique Morphologic Features of Nonsteroidal Anti-Inflammatory Drug (NSAID) Enteropathy in the Terminal Ileum
  Jessica Nguyen, Sherry Lee, Guang-Yu Yang
  International Journal of Surgical Pathology.2022; 30(6): 616.     CrossRef
• NSAIDs, gastrointestinal toxicity and inflammatory bowel disease
  Gonzalo Hijos-Mallada, Carlos Sostres, Fernando Gomollón
  Gastroenterología y Hepatología (English Edition).2022; 45(3): 215.     CrossRef
• Effect of the combination of mexidol and diclofenac sodium on exudative inflammation in rats after ten-day preventive oral administration
  E. A. Ivanova, A. G. Vasilchuk, A. I. Matyushkin, T. A. Voronina
  Pharmacokinetics and Pharmacodynamics.2022; (1): 14.     CrossRef
• The role of Zinc L-Carnosine in the prevention and treatment of gastrointestinal mucosal disease in humans: a review.
  Konstantinos Efthymakis, Matteo Neri
  Clinics and Research in Hepatology and Gastroenterology.2022; 46(7): 101954.     CrossRef
• Therapeutic Versus Preventative Use of Ginkgo biloba Extract (EGb 761) against Indomethacin-Induced Gastric Ulcer in Mice
  Ahmed M. Abd-Eldayem, Sulaiman Mohammed Alnasser, Hanan H. Abd-Elhafeez, Soha A. Soliman, Rania A. Abdel-Emam
  Molecules.2022; 27(17): 5598.     CrossRef
• Effects of Canine-Obtained Lactic-Acid Bacteria on the Fecal Microbiota and Inflammatory Markers in Dogs Receiving Non-Steroidal Anti-Inflammatory Treatment
  Kristin M. V. Herstad, Hilde Vinje, Ellen Skancke, Terese Næverdal, Francisca Corral, Ann-Katrin Llarena, Romy M. Heilmann, Jan S. Suchodolski, Joerg M. Steiner, Nicole Frost Nyquist
  Animals.2022; 12(19): 2519.     CrossRef
• The Different Patterns of Over-the-Counter Nonsteroidal Anti-Inflammatory Drugs or Analgesics Use in Patients with Chronic Kidney Disease and the General Population
  Maria Mulka-Gierek, Natalia Krata, Bartosz Foroncewicz, Leszek Pączek, Krzysztof Mucha
  Healthcare.2022; 10(10): 2035.     CrossRef
• Manifestaciones gastrointestinales de la enfermedad de Behçet
  Nicolás Zuluaga Arbeláez, Oscar Mauricio Ardila Suarez, Andrés Chavarriaga Restrepo, Wilmer Gerardo Rojas-Zuleta
  CES Medicina.2022; 36(3): 86.     CrossRef
• Iron Deficiency Anaemia and Anaemia of Inflammation in Enteropathies Caused by Commonest Small Intestine Disorders: Current Evidence
  Olesja Basina, Jelena Derova, Aleksejs Derovs, Sandra Lejniece
  Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences..2022; 76(5-6): 561.     CrossRef
• Prominent Indomethacin-Induced Enteropathy in Fcgriib Defi-cient lupus Mice: An Impact of Macrophage Responses and Immune Deposition in Gut
  Thansita Bhunyakarnjanarat, Kanyarat Udompornpitak, Wilasinee Saisorn, Bhumdhanin Chantraprapawat, Peerapat Visitchanakun, Cong Phi Dang, Jiraphorn Issara-Amphorn, Asada Leelahavanichkul
  International Journal of Molecular Sciences.2021; 22(3): 1377.     CrossRef
• Quercetin Oxidation Metabolite Present in Onion Peel Protects Caco-2 Cells against the Oxidative Stress, NF-kB Activation, and Loss of Epithelial Barrier Function Induced by NSAIDs
  Jocelyn Fuentes, Adriano Costa de Camargo, Elías Atala, Martín Gotteland, Claudio Olea-Azar, Hernán Speisky
  Journal of Agricultural and Food Chemistry.2021; 69(7): 2157.     CrossRef
• Clinical Course of Terminal Ileal Ulcers Observed Incidentally During Colonoscopy
  Jae Hyun Kim, Jong Yoon Lee, Yong Eun Park, Jong Hoon Lee, Jongha Park, Tae Oh Kim, Won Moon, Seun Ja Park
  Digestive Diseases and Sciences.2021; 66(12): 4423.     CrossRef
• Synergistic Action of Diclofenac with Endotoxin-Mediated Inflammation Exacerbates Intestinal Injury in Vitro
  Wen Li Kelly Chen, Emily Suter, Hikaru Miyazaki, Jason Velazquez, Douglas A. Lauffenburger, Linda G. Griffith, Rebecca L. Carrier
  ACS Infectious Diseases.2021; 7(4): 838.     CrossRef
• Pure Total Flavonoids From Citrus Protect Against Nonsteroidal Anti-inflammatory Drug-Induced Small Intestine Injury by Promoting Autophagy in vivo and in vitro
  Shanshan Chen, Jianping Jiang, Guanqun Chao, Xiaojie Hong, Haijun Cao, Shuo Zhang
  Frontiers in Pharmacology.2021;[Epub]     CrossRef
• MODULATION OF MELOXICAM-INDUCED CHANGES IN GASTROINTESTINAL AND MOTOR ACTIVITY OF THE STOMACH BY APPLYING PLACENTA CRYOEXTRACT
  Fedir Hladkykh, Mykola Chyzh
  Proceedings of the Shevchenko Scientific Society. Medical Sciences.2021;[Epub]     CrossRef
• Phytochemical Investigation and HPTLC Fingerprinting Analysis ofSelaginella bryopterisEthanolic Plant Extract for Analgesic and Anti-inflammatory Activities in Animals
  Shravan Kumar Paswan, Pritt Verma, Lubna Azmi, Sajal Srivastava, Chandana Venkateswara Rao
  Journal of Biologically Active Products from Nature.2021; 11(4): 395.     CrossRef
• RETRACTED ARTICLE: Expansion of monocytic myeloid-derived suppressor cells ameliorated intestinal inflammatory response by radiation through SOCS3 expression
  You Yeon Choi, Ki Moon Seong, Hyun Jung Lee, Seung Sook Lee, Areumnuri Kim
  Cell Death & Disease.2021;[Epub]     CrossRef
• Synthesis and Biological Evaluation of Salicylic Acid Analogues of Celecoxib as a New Class of Selective Cyclooxygenase-1 Inhibitor
  Sung-Hwa Yoon, Duk-Yeon Cho, Seoung-ryoung Choi, Joo-young Lee, Dong-Kug Choi, Eunha Kim, Ju-Young Park
  Biological and Pharmaceutical Bulletin.2021; 44(9): 1230.     CrossRef
• Mucoprotective drugs can prevent and treat nonsteroidal anti-inflammatory drug-induced small bowel enteropathy: a systematic review and meta-analysis of randomized controlled trials
  Brigitta Teutsch, Eszter Boros, Szilárd Váncsa, Alex Váradi, Levente Frim, Szabolcs Kiss, Fanni Dembrovszky, Zsuzsanna Helyes, Sarlós Patrícia, Hegyi Péter, Bálint Erőss
  Therapeutic Advances in Gastroenterology.2021; 14: 175628482110387.     CrossRef
• Predictors of Positive Video Capsule Endoscopy Findings for Chronic Unexplained Abdominal Pain: Single-Center Retrospective Study and Meta-Analysis
  Wonshik Kim, Beomjae Lee, Ahyoung Yoo, Seunghan Kim, Moonkyung Joo, Jong-Jae Park
  Diagnostics.2021; 11(11): 2123.     CrossRef
• NSAID-Induced Enteropathy Affects Regulation of Hepatic Glucose Production by Decreasing GLP-1 Secretion
  Hussein Herz, Yang Song, Yuanchao Ye, Liping Tian, Benjamin Linden, Marwa Abu El Haija, Yi Chu, Justin L. Grobe, Randall W. Lengeling, Mohamad Mokadem
  Nutrients.2021; 14(1): 120.     CrossRef
• Anti-Inflammatory Properties of Diclofenac Sodium on Background of Its Combined Use With Cryopreserved Placenta Extract in Experiment
  Fedir Hladkykh
  Problems of Cryobiology and Cryomedicine.2021; 31(4): 364.     CrossRef
• Utility of intestinal ultrasound in the diagnosis and short-term follow-up of non-steroidal anti-inflammatory drug-induced enteropathy
  Matteo Pistoia, Tiziano Perrone, Anna Fiengo, Marco Vincenzo Lenti, Antonio Di Sabatino
  Internal and Emergency Medicine.2020; 15(4): 729.     CrossRef
• Consenso mexicano sobre diagnóstico, prevención y tratamiento de la gastropatía y enteropatía por antiinflamatorios no esteroideos
  M.V. Bielsa-Fernández, J.L. Tamayo-de la Cuesta, J. Lizárraga-López, J.M. Remes-Troche, R. Carmona-Sánchez, J.M. Aldana-Ledesma, J.M. Avendaño-Reyes, M.A. Ballesteros-Amozorrutia, M. De Ariño, L. de Giau-Triulzi, R. Flores-Rendón, H. Huerta-Guerrero, J.A.
  Revista de Gastroenterología de México.2020; 85(2): 190.     CrossRef
• The Mexican consensus on the diagnosis, treatment, and prevention of NSAID-induced gastropathy and enteropathy
  M.V. Bielsa-Fernández, J.L. Tamayo-de la Cuesta, J. Lizárraga-López, J.M. Remes-Troche, R. Carmona-Sánchez, J.M. Aldana-Ledesma, J.M. Avendaño-Reyes, M.A. Ballesteros-Amozorrutia, M. De Ariño, L. de Giau-Triulzi, R. Flores-Rendón, H. Huerta-Guerrero, J.A.
  Revista de Gastroenterología de México (English Edition).2020; 85(2): 190.     CrossRef
• Impact of host and environmental factors on β-glucuronidase enzymatic activity: implications for gastrointestinal serotonin
  Jacinta Walsh, Loreto Olavarria-Ramirez, Gilliard Lach, Marcus Boehme, Timothy G. Dinan, John F. Cryan, Brendan T. Griffin, Niall P. Hyland, Gerard Clarke
  American Journal of Physiology-Gastrointestinal and Liver Physiology.2020; 318(4): G816.     CrossRef
• Glycomacropeptide Ameliorates Indomethacin-Induced Enteropathy in Rats by Modifying Intestinal Inflammation and Oxidative Stress
  Daniel Cervantes-García, Armida I. Bahena-Delgado, Mariela Jiménez, Laura E. Córdova-Dávalos, Vanessa Ruiz-Esparza Palacios, Esperanza Sánchez-Alemán, María C. Martínez-Saldaña, Eva Salinas
  Molecules.2020; 25(10): 2351.     CrossRef
• Non-steroidal anti-inflammatory drug-induced enteropathy as a major risk factor for small bowel bleeding: a retrospective study
  Doo-Ho Lim, Kyoungwon Jung, Seung Bum Lee, In Kyu Park, Hee Jeong Cha, Jae Ho Park, Byung Gyu Kim, Seok Won Jung, In Du Jeong, Jae Hyun Kim, Sung Eun Kim, Won Moon, Moo In Park, Seun Ja Park
  BMC Gastroenterology.2020;[Epub]     CrossRef
• Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective
  Samik Bindu, Somnath Mazumder, Uday Bandyopadhyay
  Biochemical Pharmacology.2020; 180: 114147.     CrossRef
• NSAID–Gut Microbiota Interactions
  Damian Maseda, Emanuela Ricciotti
  Frontiers in Pharmacology.2020;[Epub]     CrossRef
• Minimal Lesions of the Small Intestinal Mucosa: More than Morphology
  Umberto Volta, Giacomo Caio, Caterina Ghirardi, Lisa Lungaro, Pasquale Mansueto, Antonio Carroccio, Roberto De Giorgio
  Digestive Diseases and Sciences.2020; 65(10): 2761.     CrossRef
• The Protective Effect of Lercanidipine on Indomethacin-Induced Gastric Ulcers in Rats
  Durdu Altuner, Tuğba Kaya, Halis Suleyman
  Brazilian Archives of Biology and Technology.2020;[Epub]     CrossRef
• Investigation of small intestinal lesions in dialysis patients using capsule endoscopy
  Fumitaka Nakajima, Yoshiyuki Furumatsu, Takatomi Yurugi, Yoshifumi Amari, Takeshi Iida, Takayuki Fukui, Takanori Kuramoto
  Hemodialysis International.2019; 23(1): 77.     CrossRef
• Gastroprotective effect of memantine in indomethacin-induced peptic ulcer in rats, a possible role for potassium channels
  Remon R. Rofaeil, Shereen S. Gaber
  Life Sciences.2019; 217: 164.     CrossRef
• Proton pump inhibitor use is associated with elevated faecal calprotectin levels. A cross-sectional study on subjects referred for colonoscopy
  David Lundgren, Vincy Eklöf, Richard Palmqvist, Johan Hultdin, Pontus Karling
  Scandinavian Journal of Gastroenterology.2019; 54(2): 152.     CrossRef
• Effects of Misoprostol for Aspirin-induced Small Bowel Enteropathy
  Dong Han Yeom, Han Seung Ryu
  The Korean Journal of Gastroenterology.2019; 73(1): 60.     CrossRef
• Effects of Drugs and Excipients on Hydration Status
  Ana M. Puga, Sara Lopez-Oliva, Carmen Trives, Teresa Partearroyo, Gregorio Varela-Moreiras
  Nutrients.2019; 11(3): 669.     CrossRef
• Small bowel ulcers
  Martin Keuchel, Niehls Kurniawan, Peter Baltes
  Current Opinion in Gastroenterology.2019; 35(3): 213.     CrossRef
• Cardiorespiratory fitness, visceral fat, and body fat, but not dietary inflammatory index, are related to C-reactive protein in cancer survivors
  Matthew A Christensen, Peter Smoak, Jonathon K Lisano, Reid Hayward, Craig Coronado, Katie Kage, Daniel Shackelford, Laura K Stewart
  Nutrition and Health.2019; 25(3): 195.     CrossRef
• Safety and tolerability of nsaids: focus on aceclofenac
  E. A. Ushkalova, S. K. Zyryanov, K. E. Zalolochina
  Medical Council.2019; (9): 110.     CrossRef
• NSAIDs disrupt intestinal homeostasis by suppressing macroautophagy in intestinal epithelial cells
  Ana M. Chamoun-Emanuelli, Laura K. Bryan, Noah D. Cohen, Taylor L. Tetrault, Joseph A. Szule, Rola Barhoumi, Canaan M. Whitfield-Cargile
  Scientific Reports.2019;[Epub]     CrossRef
• Reproduction of inflammatory bowel diseases in experiment
  A. TRUSHENKO, V. MAMCHUR
  Experimental and Clinical Physiology and Biochemistry.2019; 2019(3): 82.     CrossRef
• A Case Report on Functional Dyspepsia in a Fibromyalgia Patient with a History of Long-Term Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Use
  Keum-ji Kim, Soo-ho Cho, Ji-seon Park, Seok-jae Ko, Jae-woo Park
  The Journal of Internal Korean Medicine.2019; 40(6): 1268.     CrossRef
• Are NSAIDs Double Trouble?
  Sam Schulman, James Aisenberg
  Journal of the American College of Cardiology.2018; 72(3): 268.     CrossRef
• Microbiota–drug interactions: Impact on metabolism and efficacy of therapeutics
  Ellen M. Wilkinson, Zehra Esra Ilhan, Melissa M. Herbst-Kralovetz
  Maturitas.2018; 112: 53.     CrossRef
• Canagliflozin exerts anti-inflammatory effects by inhibiting intracellular glucose metabolism and promoting autophagy in immune cells
  Chenke Xu, Wei Wang, Jin Zhong, Fan Lei, Naihan Xu, Yaou Zhang, Weidong Xie
  Biochemical Pharmacology.2018; 152: 45.     CrossRef
• Misoprostol for NSAID-induced small bowel erosions and ulcers
  Timothy A Rockall
  The Lancet Gastroenterology & Hepatology.2018; 3(7): 447.     CrossRef
• Rebleeding rate and risk factors in nonsteroidal anti‐inflammatory drug‐induced enteropathy
  Junseok Park, Seong Ran Jeon, Jin‐Oh Kim, Hyun Gun Kim, Tae Hee Lee, Jun‐Hyung Cho, Bong Min Ko, Joon Seong Lee, Moon Sung Lee
  Journal of Digestive Diseases.2018; 19(5): 279.     CrossRef
• Nonsteroidal anti-inflammatory drugs use and risk of Parkinson disease
  Li Ren, Jie Yi, Jing Yang, Peng Li, Xueyan Cheng, Peixian Mao
  Medicine.2018; 97(37): e12172.     CrossRef

Most gastrointestinal endoscopic procedures are now performed with sedation. Moderate sedation using benzodiazepines and opioids continue to be widely used, but propofol sedation is becoming more popular because its unique pharmacokinetic properties make endoscopy almost painless, with a very predictable and rapid recovery process. There is controversy as to whether propofol should be administered only by anesthesia professionals (monitored anesthesia care) or whether properly trained non-anesthesia personnel can use propofol safely via the modalities of nurse-administered propofol sedation, computer-assisted propofol sedation or nurse-administered continuous propofol sedation. The deployment of non-anesthesia administered propofol sedation for low-risk procedures allows for optimal allocation of scarce anesthesia resources, which can be more appropriately used for more complex cases. This can address some of the current shortages in anesthesia provider supply, and can potentially reduce overall health care costs without sacrificing sedation quality. This review will discuss efficacy, safety, efficiency, cost and satisfaction issues with various modes of sedation for non-advanced, non-emergent endoscopic procedures, mainly esophagogastroduodenoscopy and colonoscopy.

Citations

Citations to this article as recorded by  

• Randomized Controlled Trial of Ketamine and Moderate Sedation for Outpatient Endoscopy in Adults
  Jerome C Edelson, Cyrus V Edelson, Don C Rockey, Amilcar L Morales, Kevin K Chung, Matthew J Robles, Johanna H Marowske, Anish A Patel, Scott F. D Edelson, Stalin R Subramanian, John G Gancayco
  Military Medicine.2024; 189(1-2): 313.     CrossRef
• Effect of moderate versus deep sedation on recovery following outpatient gastroscopy in older patients: a randomized controlled trial
  Bing Chen, Lin Lu, Jie Zhai, Zhen Hua
  Surgical Endoscopy.2024; 38(3): 1273.     CrossRef
• Quality Standards in Upper Gastrointestinal Endoscopy: Can Deep Sedation Influence It?
  Catarina Correia, Nuno Almeida, Raquel Andrade, Mariana Sant’Anna, Cláudia Macedo, David Perdigoto, Carlos Gregório, Pedro Narra Figueiredo
  GE - Portuguese Journal of Gastroenterology.2024; 31(2): 101.     CrossRef
• Remimazolam versus propofol for sedation in gastrointestinal endoscopy and colonoscopy within elderly patients: a meta-analysis of randomized controlled trials
  Wania Ahmer, Sahar Imtiaz, Daniyal Muhammad Alam, Khadija Ahmed, Barka Sajid, Juvairia Yousuf, Sunny Asnani, Muhammad Ahmed Ali Fahim, Rahmeen Ali, Marium Mansoor, Muhammad Talha Safdar, Muhammad Umair Anjum, Muhammad Hasanain, Muhammad Omar Larik
  European Journal of Clinical Pharmacology.2024; 80(4): 493.     CrossRef
• Providing Safe Anesthetic Care and Sedation for GI Endoscopy
  Sheetal Kedar, Ryan M. Chadha
  Current Anesthesiology Reports.2024; 14(2): 161.     CrossRef
• The effective dose of remimazolam in adult gastroscopy
  Rongyan Zhang, Gang Zhao, Zhangjun Yan, Hongmei Xuan, Yan Chen
  Indian Journal of Pharmacology.2024; 56(1): 10.     CrossRef
• Transcutaneous electric nerve stimulation of acupuncture points improves tolerance in adults undergoing diagnostic upper gastrointestinal endoscopy: a single-center, double-blinded, randomized controlled trial
  Jun Sen Chuah, Jih Huei Tan, Mohamad Adam Bujang, Koon Khee Chan, Nik Ritza Kosai
  Surgical Endoscopy.2024; 38(6): 3279.     CrossRef
• Marijuana and endoscopy: the effects of marijuana on sedation
  Justin Kosirog, Christopher Bouvette, Jiteshwar Pannu, Jalal Gondal, Mohammad Madhoun
  Gastrointestinal Endoscopy.2024; 100(2): 177.     CrossRef
• Remimazolam for sedation in gastrointestinal endoscopy: A comprehensive review
  Dushyant Singh Dahiya, Ganesh Kumar, Syeda Parsa, Manesh Kumar Gangwani, Hassam Ali, Amir Humza Sohail, Saqr Alsakarneh, Umar Hayat, Sheza Malik, Yash R Shah, Bhanu Siva Mohan Pinnam, Sahib Singh, Islam Mohamed, Adishwar Rao, Saurabh Chandan, Mohammad Al-
  World Journal of Gastrointestinal Endoscopy.2024; 16(7): 385.     CrossRef
• The relationship between demographics and reactions during endoscopy under moderate sedation.
  İsmail Çalıkoğlu, Alaaddin Aydın, Şeref Oray, Sercan Yüksel, Uğur Topal, Erdal Karaköse, Zafer Teke, Hasan Bektaş
  Cukurova Anestezi ve Cerrahi Bilimler Dergisi.2024; 7(2): 94.     CrossRef
• Remimazolam and Its Place in the Current Landscape of Procedural Sedation and General Anesthesia
  Matthew Brohan, Janette Brohan, Basavana Goudra
  Journal of Clinical Medicine.2024; 13(15): 4362.     CrossRef
• Effect of visual distraction on pain in adults undergoing colonoscopy: a meta-analysis
  Yuan-Yuan Zhang, Ramoo Vimala, Ping Lei Chui, Ida Normiha Hilmi
  Surgical Endoscopy.2023; 37(4): 2633.     CrossRef
• Use of Dexmedetomidine in Conscious Sedation for Oesophageal Stent Placement in a High-Risk Patient
  Prashant Sirohiya, Smita Reddy, Jasmeet Gill, Naveen Kumar
  Journal of Pain & Palliative Care Pharmacotherapy.2023; 37(2): 114.     CrossRef
• The Emerging Role of Virtual Reality as an Adjunct to Procedural Sedation and Anesthesia: A Narrative Review
  Rita Hitching, Hunter G. Hoffman, Azucena Garcia-Palacios, Maheen M. Adamson, Esmeralda Madrigal, Wadee Alhalabi, Ahad Alhudali, Mariana Sampaio, Barry Peterson, Miles R. Fontenot, Keira P. Mason
  Journal of Clinical Medicine.2023; 12(3): 843.     CrossRef
• A framework for the assessment and treatment of patients for failed sedation in non-operating room settings
  George Tewfik, Daniel Rodriguez, Erica Spano
  Journal of Clinical Anesthesia.2023; 86: 111078.     CrossRef
• Time and Motion at the Endoscopy Unit—A University Hospital Experience
  Simon Söderberg, Nils Nyhlin, Axelina Moro, Christina Figaro, Emelie Fransson, Jennie Stefansdotter, Malin Schagerström, Maria Lindblad, Martin Ahlzén, Olga Zukovets, Sofia Borell, Viktoria Johansson, Marianne Axman, Anette Wendt, Hanna Falck, Michiel A.
  Health Services Research and Managerial Epidemiology.2023; 10: 233339282311598.     CrossRef
• Gelatin‐Based Ingestible Impedance Sensor to Evaluate Gastrointestinal Epithelial Barriers
  Gaurav Balakrishnan, Arnav Bhat, Durva Naik, Julie Shin Kim, Sona Marukyan, Lily Gido, Mia Ritter, Aditya S. Khair, Christopher J. Bettinger
  Advanced Materials.2023;[Epub]     CrossRef
• Ciprofol versus propofol for sedation in gastrointestinal endoscopy: protocol for a systematic review and meta-analysis
  Xiaoyu Qin, Xiaoting Lu, Lu Tang, Chunai Wang, Jianjun Xue
  BMJ Open.2023; 13(5): e071438.     CrossRef
• Comparison of the Sedative Effect of Ketamine, Magnesium Sulfate, and Propofol in Patients Undergoing Upper Gastrointestinal Endoscopy: Double-Blinded Randomized Clinical Trial
  Hamed Shafiee, Farahnaz Riahipour, Ahmad Hormati, Sajjad Ahmadpour, Mohammad Amin Habibi, Mostafa Vahedian, Reza Aminnejad, Mohammad Saeidi
  CNS & Neurological Disorders - Drug Targets.2023; 22(8): 1259.     CrossRef
• Nebulised dexmedetomidine for patient’s comfort and satisfaction during diagnostic upper gastrointestinal endoscopy: A double-blind randomised controlled study
  Bhavna Sriramka, Shikha Awal, Diptimayee Mallik, Jimmy Narayan
  Indian Journal of Anaesthesia.2023; 67(9): 825.     CrossRef
• Nurse-Administered Propofol Sedation Training Curricula and Propofol Administration in Digestive Endoscopy Procedures
  Andrea Minciullo, Lucia Filomeno
  Gastroenterology Nursing.2023;[Epub]     CrossRef
• Operational outcomes of propofol sedation versus fentanyl, midazolam and diphenhydramine sedation for endoscopies and colonoscopies at an academic medical center
  Andrew L. Mariotti, Jack Pattee, Steven A. Edmundowicz, Terran D. Hardesty, Savita M. Sharma, M. G. Lemley, Scott D. Rist, Nathaen Weitzel, Adeel A. Faruki, Stefano Turi
  PLOS ONE.2023; 18(11): e0294418.     CrossRef
• Impact of High-Flow Nasal Cannula Oxygenation on the Prevention of Hypoxia During Endoscopic Retrograde Cholangiopancreatography in Elderly Patients: A Randomized Clinical Trial
  Man-Jong Lee, Boram Cha, Jin-Seok Park, Jung Soo Kim, Sang Yong Cho, Joung-Ho Han, Mi Hwa Park, Chunwoo Yang, Seok Jeong
  Digestive Diseases and Sciences.2022; 67(8): 4154.     CrossRef
• Anesthesiological support during gastroscopy and colonoscopy: availability, effectiveness and safety of applied methods
  A. M. Dolgunov, D. A. Dolgunov, T. V. Balashova, N. A. Andreeva
  Pacific Medical Journal.2022; (4): 34.     CrossRef
• Efficacy of high flow nasal oxygenation against hypoxemia in sedated patients receiving gastrointestinal endoscopic procedures: A systematic review and meta-analysis
  Kuo-Chuan Hung, Ying-Jen Chang, I-Wen Chen, Tien-Chou Soong, Chun-Ning Ho, Chung-Hsi Hsing, Chin-Chen Chu, Jen-Yin Chen, Cheuk-Kwan Sun
  Journal of Clinical Anesthesia.2022; 77: 110651.     CrossRef
• Comparing performance of Wei nasal jet tube and nasal cannula during flexible bronchoscopy with sedation
  Xing Tao, Fu-Shan Xue, Bin Hu, Tian Tian
  European Journal of Anaesthesiology.2022; 39(3): 297.     CrossRef
• Factors Associated with Withdrawal Time in European Colonoscopy Practice: Findings of the European Colonoscopy Quality Investigation (ECQI) Group
  Cristiano Spada, Anastasios Koulaouzidis, Cesare Hassan, Pedro Amaro, Anurag Agrawal, Lene Brink, Wolfgang Fischbach, Matthias Hünger, Rodrigo Jover, Urpo Kinnunen, Akiko Ono, Árpád Patai, Silvia Pecere, Lucio Petruzziello, Jürgen F. Riemann, Harry Staine
  Diagnostics.2022; 12(2): 503.     CrossRef
• Evaluation of anesthesia quality with three methods: “propofol + fentanyl” vs. “propofol + fentanyl + lidocaine” vs. “propofol + fentanyl + lidocaine + ketamine” in patients referred to the scoping ward
  Sepehr Edalatkhah, Ebrahim Hazrati, Mahmoodreza Hashemi, Alireza Golaghaei, Behroz Kheradmand, Mohamadreza Rafiei
  Journal of Family Medicine and Primary Care.2022; 11(2): 672.     CrossRef
• Post-procedure Rhinitis After Use of Sedatives and Supplemental Nasal Oxygen
  Sharmela Brijmohan, Tanganyika Barnes
  Cureus.2022;[Epub]     CrossRef
• Meta-analysis comparing the efficiency of high-flow nasal cannula versus low-flow nasal cannula in patients undergoing endoscopic retrograde cholangiopancreatography
  Mohamed Gamal, Manar Ahmed Kamal, Mohamed Abuelazm, Amman Yousaf, Basel Abdelazeem
  Baylor University Medical Center Proceedings.2022; 35(4): 485.     CrossRef
• High flow nasal oxygen versus conventional oxygen therapy in gastrointestinal endoscopy with conscious sedation: Systematic review and meta‐analysis with trial sequential analysis
  Wan‐Jie Gu, Hao‐Tian Wang, Jiao Huang, Jun‐Peng Pei, Kazuhiro Nishiyama, Masanobu Abe, Zhe‐Ming Zhao, Chun‐Dong Zhang
  Digestive Endoscopy.2022; 34(6): 1136.     CrossRef
• Illicit Drug Use and Endoscopy: When Do We Say No?
  John P. Gallagher, Patrick A. Twohig, Agnes Crnic, Fedja A. Rochling
  Digestive Diseases and Sciences.2022; 67(12): 5371.     CrossRef
• Efficacy and Safety of Exploring Deeper Sections of the Infrapapillary Area of the Duodenum by Using Sedative Esophagogastroduodenoscopy
  Ming-Tse Hsu, Chi-Yi Chen, Kai-Sheng Liao, Wei-Sheng Chung, Tatsuya Toyokawa
  Gastroenterology Research and Practice.2022; 2022: 1.     CrossRef
• Ketamine as the main analgesic agent during analgesia-based sedation for elective colonoscopy – A randomised, double-blind, control study
  Mirza Kovačević, Nermina Rizvanović, AdisaŠabanović Adilović, Jasmina Smajić, Selma Sijerčić
  Saudi Journal of Anaesthesia.2022; 16(4): 423.     CrossRef
• Efficacy and safety of midazolam combined with dezocine for sedation and analgesia in digestive endoscopy: A prospective open single-center study
  Yongpeng Chen, Jiachen Sun, Yi Lu, Liping Fu, Xueyuan Xiang, Yanan Liu, Xianhua Zhuo, Mirigul Kurban, Chujun Li
  Frontiers in Pharmacology.2022;[Epub]     CrossRef
• Nurse-Administered Propofol Continuous Infusion Sedation for Gastrointestinal Endoscopy in Patients Who Are Difficult to Sedate
  Hyun Seok Lee, Navroop Nagra, Danielle La Selva, Richard A. Kozarek, Andrew Ross, Wade Weigel, Ryan Beecher, Michael Chiorean, Michael Gluck, Elisa Boden, Nanda Venu, Rajesh Krishnamoorthi, Michael Larsen, Otto S. Lin
  Clinical Gastroenterology and Hepatology.2021; 19(1): 180.     CrossRef
• Estimation of effective dose of propofol mono‐sedation for successful insertion of upper gastrointestinal endoscope in healthy, non‐obese Chinese adults
  Fu K. Liu, Lei Wan, Liu J. Z. Shao, Yi Zou, Shao H. Liu, Fu S. Xue
  Journal of Clinical Pharmacy and Therapeutics.2021; 46(2): 484.     CrossRef
• Effect of intravenous administration of lidocaine on the ED50 of propofol induction dose during gastroscopy in adult patients: A randomized, controlled study
  Haoran Liu, Mengmeng Chen, Chaohui Lian, Junzheng Wu, Wangning Shangguan
  Journal of Clinical Pharmacy and Therapeutics.2021; 46(3): 711.     CrossRef
• Leitlinien in der Praxis: Sedierung in der gastrointestinalen Endoskopie
  Peter H. Tonner
  AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie.2021; 56(03): 201.     CrossRef
• Nurse-Administered Propofol Continuous Infusion Sedation: A New Paradigm for Gastrointestinal Procedural Sedation
  Otto S. Lin, Danielle La Selva, Richard A. Kozarek, Wade Weigel, Ryan Beecher, Michael Gluck, Michael Chiorean, Elisa Boden, Nanda Venu, Rajesh Krishnamoorthi, Michael Larsen, Andrew Ross
  American Journal of Gastroenterology.2021; 116(4): 710.     CrossRef
• The importance of preoperative instructions and their role in patient safety in the provision of conscious sedation for dental care
  Thomas Flavell, Katherine Wilson, Nicholas Girdler
  Faculty Dental Journal.2021; 12(2): 97.     CrossRef
• High-flow nasal oxygenation or standard oxygenation for gastrointestinal endoscopy with sedation in patients at risk of hypoxaemia: a multicentre randomised controlled trial (ODEPHI trial)
  Mai-Anh Nay, Lucie Fromont, Axelle Eugene, Jean-Louis Marcueyz, Willy-Serge Mfam, Olivier Baert, Francis Remerand, Céline Ravry, Adrien Auvet, Thierry Boulain
  British Journal of Anaesthesia.2021; 127(1): 133.     CrossRef
• Propofol Combined with Fentanyl Is Superior to Propofol Alone in Sedation Protocols for Painless Gastrointestinal Endoscopy
  Jie Chang, Chun Yang, Songwen Tan
  Journal of Nanomaterials.2021; 2021: 1.     CrossRef
• Oxygen supplementation during upper gastrointestinal endoscopy with sedation
  Bin Hu, Tian Tian, Fu-Shan Xue
  Canadian Journal of Anesthesia/Journal canadien d'anesthésie.2021; 68(9): 1444.     CrossRef
• Comparison of Lidocaine Spray and Lidocaine Ice Popsicle in Patients Undergoing Unsedated Esophagogastroduodenoscopy: A Single Center Prospective Randomized Controlled Trial
  Prasit Mahawongkajit, Nantawat Talalak, Neranchala Soonthornkes
  Clinical and Experimental Gastroenterology.2021; Volume 14: 209.     CrossRef
• Autonomous Nervous Response During Sedation in Colonoscopy and the Relationship With Clinician Satisfaction
  Alexander Hann, Sascha Gruss, Sebastian Goetze, Niklas Mehlhase, Stephan Frisch, Benjamin Walter, Steffen Walter
  Frontiers in Medicine.2021;[Epub]     CrossRef
• Comparative Safety Profiles of Sedatives Commonly Used in Clinical Practice: A 10-Year Nationwide Pharmacovigilance Study in Korea
  Yeo-Jin Choi, Seung-Won Yang, Won-Gun Kwack, Jun-Kyu Lee, Tae-Hee Lee, Jae-Yong Jang, Eun-Kyoung Chung
  Pharmaceuticals.2021; 14(8): 783.     CrossRef
• Thoughts on factors related to colonoscopy quality
  Jing-Zhai Wang, Yu Zhang, Qiang Guo
  World Chinese Journal of Digestology.2021; 29(17): 977.     CrossRef
• Risk Factors for Prolonged Hospital Stay after Endoscopy
  Toshihiro Nishizawa, Shuntaro Yoshida, Osamu Toyoshima, Tatsuya Matsuno, Masataka Irokawa, Toru Arano, Hirotoshi Ebinuma, Hidekazu Suzuki, Takanori Kanai, Kazuhiko Koike
  Clinical Endoscopy.2021; 54(6): 851.     CrossRef
• Safety of endoscopist-administered deep sedation with propofol in patients ASA III
  Lucía Medina-Prado, Juan Martínez, Maryana Bozhychko, Carolina Mangas-Sanjuan, Luis Compañy Catal�, Francisco Ruiz Gómez, José Ramón Aparicio Tormo, Juan Antonio Casellas Valde
  Revista Española de Enfermedades Digestivas.2021;[Epub]     CrossRef
• Sedation During Endoscopy in Patients with Cirrhosis: Safety and Predictors of Adverse Events
  Jerome Edelson, Alejandro L. Suarez, Jingwen Zhang, Don C. Rockey
  Digestive Diseases and Sciences.2020; 65(4): 1258.     CrossRef
• Are Gastrointestinal Endoscopic Procedures Performed by Anesthesiologists Safer Than When Sedation is Given by the Endoscopist?
  Richard Kozarek
  Clinical Gastroenterology and Hepatology.2020; 18(9): 1935.     CrossRef
• Robotic colonoscopy: efficacy, tolerability and safety. Preliminary clinical results from a pilot study
  Antonello Trecca, Filippo Catalano, Antonino Bella, Raffaele Borghini
  Surgical Endoscopy.2020; 34(3): 1442.     CrossRef
• A randomized double-blinded non-inferiority trial comparing fentanyl and midazolam with pethidine and diazepam for pain relief during oocyte retrieval
  Shui Fan Lai, Mei Ting Lam, Hang Wun Raymond Li, Ernest Hung Yu Ng
  Reproductive BioMedicine Online.2020; 40(5): 653.     CrossRef
• Effects of remifentanil on awakening of propofol sedated patients submitted to upper gastrointestinal endoscopy: a randomized clinical trial
  Gustavo Nadal Uliana, Elizabeth Milla Tambara, Renato Tambara Filho, Giorgio Alfredo Pedroso Baretta
  Brazilian Journal of Anesthesiology (English Edition).2020; 70(3): 262.     CrossRef
• Efeitos do remifentanil sobre despertar de pacientes sedados com propofol para endoscopia digestiva alta: estudo clínico randomizado
  Gustavo Nadal Uliana, Elizabeth Milla Tambara, Renato Tambara Filho, Giorgio Alfredo Pedroso Baretta
  Brazilian Journal of Anesthesiology.2020; 70(3): 262.     CrossRef
• Medical, Political, and Economic Considerations for the Use of MAC for Endoscopic Sedation: Big Price, Little Justification?
  Basavana Goudra, Preet Mohinder Singh, Gary R. Lichtenstein
  Digestive Diseases and Sciences.2020; 65(9): 2466.     CrossRef
• Deep sedation using propofol target-controlled infusion for gastrointestinal endoscopic procedures: a retrospective cohort study
  María E. García Guzzo, María S. Fernandez, Delfina Sanchez Novas, Sandra S. Salgado, Sergio A. Terrasa, Gonzalo Domenech, Carlos A. Teijido
  BMC Anesthesiology.2020;[Epub]     CrossRef
• Risk Factors for Predicting Hypoxia in Adult Patients Undergoing Bronchoscopy under Sedation
  Ji Soo Choi, Eun Hye Lee, Sang Hoon Lee, Ah Young Leem, Kyung Soo Chung, Song Yee Kim, Ji Ye Jung, Young Ae Kang, Moo Suk Park, Joon Chang, Young Sam Kim
  Tuberculosis and Respiratory Diseases.2020; 83(4): 276.     CrossRef
• Efficacy and Safety of Etomidate in Comparison with Propofol or Midazolam as Sedative for Upper Gastrointestinal Endoscopy
  Jae Hyun Kim, Sanghwan Byun, Youn Jung Choi, Hye Jung Kwon, Kyoungwon Jung, Sung Eun Kim, Moo In Park, Won Moon, Seun Ja Park
  Clinical Endoscopy.2020; 53(5): 555.     CrossRef
• Feasibility of a transmucosal sublingual fentanyl tablet as a procedural pain treatment in colonoscopy patients: a prospective placebo-controlled randomized study
  Mari Fihlman, E. Karru, P. Varpe, H. Huhtinen, N. Hagelberg, T. I. Saari, K. T. Olkkola
  Scientific Reports.2020;[Epub]     CrossRef
• Discharge following sedation for endoscopic procedures: a best practice implementation project
  Xianli Cai, Alexa McArthur
  JBI Evidence Synthesis.2020; 18(2): 348.     CrossRef
• Acute abdominal obstruction: Colon stent or emergency surgery? An evidence-based review
  Igor Braga Ribeiro, Diogo Turiani Hourneaux de Moura, Christopher C Thompson, Eduardo Guimarães Hourneaux de Moura
  World Journal of Gastrointestinal Endoscopy.2019; 11(3): 193.     CrossRef
• Factors related to paradoxical reactions during propofol-induced sedated endoscopy
  Seung Hwa Lee, Gyu Min Lee, Dong Ryul Lee, Jung Un Lee
  Scandinavian Journal of Gastroenterology.2019; 54(3): 371.     CrossRef
• The rise, fall, and future direction of computer-assisted personalized sedation
  James F. Martin, Paul J. Niklewski, Jeffrey D. White
  Current Opinion in Anaesthesiology.2019; 32(4): 480.     CrossRef
• Efficiency and scheduling in the nonoperating room anesthesia suite
  Bijan Navidi, Kianusch Kiai
  Current Opinion in Anaesthesiology.2019; 32(4): 498.     CrossRef
• High-flow nasal cannula oxygen therapy and hypoxia during gastroscopy with propofol sedation: a randomized multicenter clinical trial
  Yuxuan Lin, Xiaoqing Zhang, Lizhi Li, Mengyun Wei, Bin Zhao, Xiaojing Wang, Zhiying Pan, Jie Tian, Weifeng Yu, Diansan Su
  Gastrointestinal Endoscopy.2019; 90(4): 591.     CrossRef
• Propofol vs traditional sedatives for sedation in endoscopy: A systematic review and meta-analysis
  Aureo Augusto de Almeida Delgado, Diogo Turiani Hourneaux de Moura, Igor Braga Ribeiro, Ahmad Najdat Bazarbashi, Marcos Eduardo Lera dos Santos, Wanderley Marques Bernardo, Eduardo Guimarães Hourneaux de Moura
  World J Gastrointest Endosc.2019; 11(11): 573.     CrossRef
• Propofol for gastrointestinal endoscopy
  Toshihiro Nishizawa, Hidekazu Suzuki
  United European Gastroenterology Journal.2018; 6(6): 801.     CrossRef
• Safety of applying midazolam-ketamine-propofol sedation combination under the supervision of endoscopy nurse with patient-controlled analgesia pump in colonoscopy
  Selda Kayaaltı, Ömer Kayaaltı
  World Journal of Clinical Cases.2018; 6(16): 1146.     CrossRef

Citations

Citations to this article as recorded by  

• Video capsule endoscopy in inflammatory bowel disease
  Kenji J.L. Limpias Kamiya, Naoki Hosoe, Yukie Hayashi, Takaaki Kawaguchi, Kaoru Takabayashi, Haruhiko Ogata, Takanori Kanai
  DEN Open.2022;[Epub]     CrossRef
• Enteroscopy in Crohn’s Disease: Are There Any Changes in Role or Outcomes Over Time? A KASID Multicenter Study
  Seong Ran Jeon, Jin-Oh Kim, Jeong-Sik Byeon, Dong-Hoon Yang, Bong Min Ko, Hyeon Jeong Goong, Hyun Joo Jang, Soo Jung Park, Eun Ran Kim, Sung Noh Hong, Jong Pil Im, Seong-Eun Kim, Ja Seol Koo, Chang Soo Eun, Dong Kyung Chang
  Gut and Liver.2021; 15(3): 375.     CrossRef
• Capsule Endoscopy in Crohn’s Disease—From a Relative Contraindication to Habitual Monitoring Tool
  Adi Lahat, Ido Veisman
  Diagnostics.2021; 11(10): 1737.     CrossRef
• Use of small bowel capsule endoscopy in clinical practice: how has it performed?
  Seong Ran Jeon
  The Korean Journal of Internal Medicine.2020; 35(4): 854.     CrossRef
• Pursuing therapeutic success in Crohn’s disease: A matter of definition, tools and longterm outcomes
  Loredana Goran, Monica State, Ana Maria Negreanu, Lucian Negreanu
  European Journal of Inflammation.2020; 18: 205873922096289.     CrossRef
• Capsule endoscopy: Current status and role in Crohn’s disease
  Loredana Goran, Ana Maria Negreanu, Ana Stemate, Lucian Negreanu
  World Journal of Gastrointestinal Endoscopy.2018; 10(9): 184.     CrossRef
• Role of capsule endoscopy in suspected or established Crohn's disease in real practice
  Hyun Joo Jang
  Intestinal Research.2017; 15(4): 431.     CrossRef

Citations

Citations to this article as recorded by  

• The treatment of inflammatory bowel disease with monoclonal antibodies in Asia
  Yu Chen, Guolin Zhang, Yuewen Yang, Shuangshuang Zhang, Haozheng Jiang, Kang Tian, Arenbaoligao, Dapeng Chen
  Biomedicine & Pharmacotherapy.2023; 157: 114081.     CrossRef
• A Retrospective Cohort Study of Clinical Features and Treatment Patterns With Ustekinumab in Patients With Crohn Disease Utilizing a Health Care Database in Japan
  Yanfang Liu, Choo Hua Goh, Hong Qiu, Kuan-Chih Huang, Hsingwen Chung, Carine Saadoun
  Annals of Pharmacotherapy.2023; 57(9): 1053.     CrossRef
• Real-world effectiveness and safety of ustekinumab induction therapy for Korean patients with Crohn’s disease: a KASID prospective multicenter study
  Kyunghwan Oh, Hee Seung Hong, Nam Seok Ham, Jungbok Lee, Sang Hyoung Park, Suk-Kyun Yang, Hyuk Yoon, You Sun Kim, Chang Hwan Choi, Byong Duk Ye
  Intestinal Research.2023; 21(1): 137.     CrossRef
• A critical review of ustekinumab for the treatment of active ulcerative colitis in adults
  Sophie Vieujean, Edouard Louis, Silvio Danese, Laurent Peyrin-Biroulet
  Expert Review of Gastroenterology & Hepatology.2023; 17(5): 413.     CrossRef
• Feasibility of a Clinical Decision Support Tool for Ustekinumab to Predict Clinical Remission and Relapse in Patients With Crohn’s Disease: A Multicenter Observational Study
  Jihye Park, Jaeyoung Chun, Hyuk Yoon, Jae Hee Cheon
  Inflammatory Bowel Diseases.2022;[Epub]     CrossRef
• Management of inflammatory bowel disease beyond tumor necrosis factor inhibitors: novel biologics and small-molecule drugs
  Soo-Young Na, You Sun Kim
  The Korean Journal of Internal Medicine.2022; 37(5): 906.     CrossRef
• Association of Anti–Tumor Necrosis Factor Therapy With Mortality Among Veterans With Inflammatory Bowel Disease
  Shirley Cohen-Mekelburg, Beth I. Wallace, Tony Van, Wyndy L. Wiitala, Shail M. Govani, Jennifer Burns, Rachel Lipson, Huifeng Yun, Jason Hou, James D. Lewis, Jason A. Dominitz, Akbar K. Waljee
  JAMA Network Open.2021; 4(3): e210313.     CrossRef
• Evidence-based clinical practice guidelines for inflammatory bowel disease 2020
  Hiroshi Nakase, Motoi Uchino, Shinichiro Shinzaki, Minoru Matsuura, Katsuyoshi Matsuoka, Taku Kobayashi, Masayuki Saruta, Fumihito Hirai, Keisuke Hata, Sakiko Hiraoka, Motohiro Esaki, Ken Sugimoto, Toshimitsu Fuji, Kenji Watanabe, Shiro Nakamura, Nagamu I
  Journal of Gastroenterology.2021; 56(6): 489.     CrossRef
• Safety and effectiveness of ustekinumab in Crohn's disease: Interim results of post‐marketing surveillance in Japan
  Seiji Yokoyama, Teita Asano, Katsumasa Nagano, Hiroaki Tsuchiya, Masayuki Takagishi, Shigeharu Tsujioka, Naomi Miura, Takayuki Matsumoto
  Journal of Gastroenterology and Hepatology.2021; 36(11): 3069.     CrossRef
• Translating Treg Therapy for Inflammatory Bowel Disease in Humanized Mice
  Sushmita Negi, Sheetal Saini, Nikunj Tandel, Kiran Sahu, Ravi P.N. Mishra, Rajeev K. Tyagi
  Cells.2021; 10(8): 1847.     CrossRef
• Efficacy and safety of ustekinumab in East Asian patients with moderately to severely active ulcerative colitis: a subpopulation analysis of global phase 3 induction and maintenance studies (UNIFI)
  Tadakazu Hisamatsu, Hyo Jong Kim, Satoshi Motoya, Yasuo Suzuki, Yoshifumi Ohnishi, Noriyuki Fujii, Nobuko Matsushima, Richuan Zheng, Colleen W. Marano
  Intestinal Research.2021; 19(4): 386.     CrossRef
• Efficacy and safety of a new vedolizumab subcutaneous formulation in Japanese patients with moderately to severely active ulcerative colitis
  Taku Kobayashi, Hiroaki Ito, Toshifumi Ashida, Tadashi Yokoyama, Masakazu Nagahori, Tomoki Inaba, Mitsuhiro Shikamura, Takayoshi Yamaguchi, Tetsuharu Hori, Philippe Pinton, Mamoru Watanabe, Toshifumi Hibi
  Intestinal Research.2021; 19(4): 448.     CrossRef
• Interleukin 23 and autoimmune diseases: current and possible future therapies
  Ahmad Ismail Khaled Abdo, Gee Jun Tye
  Inflammation Research.2020; 69(5): 463.     CrossRef
• Long-Term Clinical Effectiveness of Ustekinumab in Patients With Crohn’s Disease: A Retrospective Cohort Study
  Takahiro Ito, Atsuo Maemoto, Takehiko Katsurada, Hiroki Tanaka, Satoshi Motoya, Nobuhiro Ueno, Mikihiro Fujiya, Toshifumi Ashida, Daisuke Hirayama, Hiroshi Nakase
  Crohn's & Colitis 360.2020;[Epub]     CrossRef
• Novel drug delivery systems of Chinese medicine for the treatment of inflammatory bowel disease
  Caifang Gao, Lijuan Liu, Yangyang Zhou, Zhaoxiang Bian, Shengpeng Wang, Yitao Wang
  Chinese Medicine.2019;[Epub]     CrossRef
• Ustekinumab is effective in biological refractory Crohn’s disease patients–regardless of approval study selection criteria
  Sadik Saman, Martin Goetz, Judith Wendler, Nisar P. Malek, Jan Wehkamp, Thomas Klag
  Intestinal Research.2019; 17(3): 340.     CrossRef
• Perspectives on Current and Novel Treatments for Inflammatory Bowel Disease
  Soo-Young Na, Won Moon
  Gut and Liver.2019; 13(6): 604.     CrossRef
• Anti-IL-12/23p40 antibodies for maintenance of remission in Crohn's disease
  Sarah C Davies, Tran M Nguyen, Claire E Parker, John K MacDonald, Vipul Jairath, Reena Khanna
  Cochrane Database of Systematic Reviews.2019;[Epub]     CrossRef
• Novel treatments for inflammatory bowel disease
  Hyo Sun Lee, Soo-Kyung Park, Dong Il Park
  The Korean Journal of Internal Medicine.2018; 33(1): 20.     CrossRef
• Emerging Therapies: What Are Promising in the Near Future?
  Geom Seog Seo, Sung Hee Lee
  The Korean Journal of Gastroenterology.2018; 71(2): 81.     CrossRef

Citations

Citations to this article as recorded by  

• Management of Crohn’s disease in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease updated in 2023
  Jia-Feng Wu, Hsu-Heng Yen, Horng-Yuan Wang, Ting-An Chang, Chung-Hsin Chang, Chen-Wang Chang, Te-Hsin Chao, Jen-Wei Chou, Yenn-Hwei Chou, Chiao-Hsiung Chuang, Wen-Hung Hsu, Tzu-Chi Hsu, Tien-Yu Huang, Tsung-I Hung, Puo-Hsien Le, Chun-Che Lin, Chun-Chi Lin
  Intestinal Research.2024; 22(3): 250.     CrossRef
• Real‐world experience of adalimumab therapy for patients with ulcerative colitis: A single tertiary medical center experience in Central Taiwan
  Hsu‐Heng Yen, Yu‐Chun Hsu, Chu‐Hsuan Kuo, Tsui‐Chun Hsu, Yang‐Yuan Chen
  Advances in Digestive Medicine.2023; 10(1): 28.     CrossRef
• Suboptimal Outcomes and Retreatment Rate of Patients With Crohn's Disease After Forced Discontinuation of Biologics: A Nationwide Population‐Based Study
  Nai‐Yu Chen, Chiao‐Hsiung Chuang, Yu‐Ching Chang, Yea‐Huei Kao Yang, Peng‐Hsu Chen, Ching‐Lan Cheng
  Clinical Pharmacology & Therapeutics.2023; 114(4): 914.     CrossRef
• Prediction of Relapse After Anti–Tumor Necrosis Factor Cessation in Crohn’s Disease: Individual Participant Data Meta-analysis of 1317 Patients From 14 Studies
  Renske W.M. Pauwels, C. Janneke van der Woude, Daan Nieboer, Ewout W. Steyerberg, María J. Casanova, Javier P. Gisbert, Nick A. Kennedy, Charlie W. Lees, Edouard Louis, Tamás Molnár, Kata Szántó, Eduardo Leo, Steven Bots, Robert Downey, Milan Lukas, Wei C
  Clinical Gastroenterology and Hepatology.2022; 20(8): 1671.     CrossRef
• Adalimumab Efficacy for Management of Inflammatory Bowel Disease in Southwest Region of Iran
  Pezhman Alavinejad, Sana Delavari, Abazar Parsi, Ali Akbar Shayesteh
  Modern Care Journal.2022;[Epub]     CrossRef
• Clinical Features and Outcomes of Tuberculosis in Inflammatory Bowel Disease Patients Treated with Anti-tumor Necrosis Factor Therapy
  Jihye Kim, Jong Pil Im, Jae-Joon Yim, Chang Kyun Lee, Dong Il Park, Chang Soo Eun, Sung-Ae Jung, Jeong Eun Shin, Kang-Moon Lee, Jae Hee Cheon
  The Korean Journal of Gastroenterology.2020; 75(1): 29.     CrossRef
• Epidemiological trend in inflammatory bowel disease in Taiwan from 2001 to 2015: a nationwide populationbased study
  Hsu-Heng Yen, Meng-Tzu Weng, Chien-Chih Tung, Yu-Ting Wang, Yuan Ting Chang, Chin-Hao Chang, Ming-Jium Shieh, Jau-Min Wong, Shu-Chen Wei
  Intestinal Research.2019; 17(1): 54.     CrossRef
• Novel drug delivery systems of Chinese medicine for the treatment of inflammatory bowel disease
  Caifang Gao, Lijuan Liu, Yangyang Zhou, Zhaoxiang Bian, Shengpeng Wang, Yitao Wang
  Chinese Medicine.2019;[Epub]     CrossRef
• Efficacy of Anti-TNF Therapy for the Treatment of Patients with Moderate-to-Severe Inflammatory Bowel Disease; a First Iranian Report
  Samaneh Mohagheghi Darehranj, Sudabeh Alatab, Homayoon Vahedi, Anahita Sadeghi, Alireza Sima, Masoud Malekzadeh, Amir Anoshiravani, Hafez Fakheri, Nasser Ebrahimi Daryani, Abdolhamid Mousavi, Fariborz Mansour-Ghanaei, Mohammad Javad Zahedi, Reza Malekzade
  Middle East Journal of Digestive Diseases.2019; 12(1): 12.     CrossRef
• Novel treatments for inflammatory bowel disease
  Hyo Sun Lee, Soo-Kyung Park, Dong Il Park
  The Korean Journal of Internal Medicine.2018; 33(1): 20.     CrossRef

Citations

Citations to this article as recorded by  

• DNA methylation modulates epigenetic regulation in colorectal cancer diagnosis, prognosis and precision medicine
  Jingxin Ye, Jianfeng Zhang, Weifeng Ding
  Exploration of Targeted Anti-tumor Therapy.2024; 5(1): 34.     CrossRef
• Pathogenesis and biomarkers of colorectal cancer by epigenetic alteration
  Chang Kyo Oh, Young-Seok Cho
  Intestinal Research.2024; 22(2): 131.     CrossRef
• Tissue factor pathway inhibitor-2 (TFPI-2)—an underappreciated partaker in cancer and metastasis
  Marek Z. Wojtukiewicz, Marta Mysliwiec, Anna Tokajuk, Joanna Kruszewska, Barbara Politynska, Anmbreen Jamroze, Anna M. Wojtukiewicz, Dean G. Tang, Kenneth V. Honn
  Cancer and Metastasis Reviews.2024;[Epub]     CrossRef
• Detecting colorectal cancer using genetic and epigenetic biomarkers: screening and diagnosis
  Yudith Annisa Ayu Rezkitha, Nur Syahadati Retno Panenggak, Maria Inge Lusida, Raissa Virgy Rianda, Isna Mahmudah, Aditya Doni Pradana, Tomohisa Uchida, Muhammad Miftahussurur
  Journal of Medicine and Life.2024; 17(1): 4.     CrossRef
• In Silico Gene Prioritization Highlights the Significance of Bone Morphogenetic Protein 4 (BMP4) Promoter Methylation across All Methylation Clusters in Colorectal Cancer
  Daša Jevšinek Skok, Nina Hauptman
  International Journal of Molecular Sciences.2023; 24(16): 12692.     CrossRef
• Novel biomarkers used for early diagnosis and tyrosine kinase inhibitors as targeted therapies in colorectal cancer
  Huafeng Jiang, Senjun Zhou, Gang Li
  Frontiers in Pharmacology.2023;[Epub]     CrossRef
• A novel screening method of DNA methylation biomarkers helps to improve the detection of colorectal cancer and precancerous lesions
  Yuan Li, Bin Li, Rou Jiang, Leen Liao, Chunting Zheng, Jie Yuan, Liuhong Zeng, Kunling Hu, Yuyu Zhang, Weijian Mei, Zhigang Hong, Binyi Xiao, Lingheng Kong, Kai Han, Jinghua Tang, Wu Jiang, Zhizhong Pan, Shenyan Zhang, Peirong Ding
  Cancer Medicine.2023; 12(21): 20626.     CrossRef
• Current Research on Molecular Biomarkers for Colorectal Cancer in Stool Samples
  Patricio Órdenes, Claudio Carril Pardo, Roberto Elizondo-Vega, Karina Oyarce
  Biology.2023; 13(1): 15.     CrossRef
• Beyond liquid biopsy: Toward non-invasive assays for distanced cancer diagnostics in pandemics
  Francesco Ferrara, Sofia Zoupanou, Elisabetta Primiceri, Zulfiqur Ali, Maria Serena Chiriacò
  Biosensors and Bioelectronics.2022; 196: 113698.     CrossRef
• Novel Diagnostic Biomarkers in Colorectal Cancer
  Aneta L. Zygulska, Piotr Pierzchalski
  International Journal of Molecular Sciences.2022; 23(2): 852.     CrossRef
• Diagnostic accuracy of multitarget stool DNA testing for colorectal cancer screening: A systematic review and meta-analysis
  Roya Dolatkhah, Saeed Dastgiri, Mohammad Asghari Jafarabadi, Hossein Mashhadi Abdolahi, Mohammad Hossein Somi
  Gastroenterología y Hepatología.2022; 45(10): 753.     CrossRef
• Technical considerations in PCR-based assay design for diagnostic DNA methylation cancer biomarkers
  Maartje Massen, Kim Lommen, Kim A. D. Wouters, Johan Vandersmissen, Wim van Criekinge, James G. Herman, Veerle Melotte, Leo J. Schouten, Manon van Engeland, Kim M. Smits
  Clinical Epigenetics.2022;[Epub]     CrossRef
• DNA methylation biomarkers in colorectal cancer: Clinical applications for precision medicine
  Nayeralsadat Fatemi, Sascha Tierling, Hamidreza Aboulkheyr Es, Maryam Varkiani, Ehsan Nazemalhosseini Mojarad, Hamid Asadzadeh Aghdaei, Jörn Walter, Mehdi Totonchi
  International Journal of Cancer.2022; 151(12): 2068.     CrossRef
• Diagnostic accuracy of multitarget stool DNA testing for colorectal cancer screening: A systematic review and meta-analysis
  Roya Dolatkhah, Saeed Dastgiri, Mohammad Asghari Jafarabadi, Hossein Mashhadi Abdolahi, Mohammad Hossein Somi
  Gastroenterología y Hepatología (English Edition).2022; 45(10): 753.     CrossRef
• Performance evaluation of stool DNA methylation tests in colorectal cancer screening: a systematic review and meta‐analysis
  Mahir Gachabayov, Edward Lebovics, Aram Rojas, Daniel M Felsenreich, Rifat Latifi, Roberto Bergamaschi
  Colorectal Disease.2021; 23(5): 1030.     CrossRef
• Fecal Multidimensional Assay for Non-Invasive Detection of Colorectal Cancer: Fecal Immunochemical Test, Stool DNA Mutation, Methylation, and Intestinal Bacteria Analysis
  Shaobo Mo, Hui Wang, Lingyu Han, Wenqiang Xiang, Weixing Dai, Pengfei Zhao, Fengchun Pei, Zhixi Su, Chengcheng Ma, Qi Li, Zhimin Wang, Sanjun Cai, Hao Wang, Rui Liu, Guoxiang Cai
  Frontiers in Oncology.2021;[Epub]     CrossRef
• Identification of DNA methylation markers for early detection of CRC indicates a role for nervous system-related genes in CRC
  Glenn Rademakers, Maartje Massen, Alexander Koch, Muriel X. Draht, Nikkie Buekers, Kim A. D. Wouters, Nathalie Vaes, Tim De Meyer, Beatriz Carvalho, Gerrit A. Meijer, James G. Herman, Kim M. Smits, Manon van Engeland, Veerle Melotte
  Clinical Epigenetics.2021;[Epub]     CrossRef
• Advances in Early Detection of Colorectal Cancer: A Focus on Non-invasive Biomarkers
  Nadia El Kadmiri
  Current Drug Targets.2021; 22(9): 1043.     CrossRef
• RETRACTED: Using Comorbidity Pattern Analysis to Detect Reliable Methylated Genes in Colorectal Cancer Verified by Stool DNA Test
  Yi-Chiao Cheng, Po-Hsien Wu, Yen-Ju Chen, Cing-Han Yang, Jhen-Li Huang, Yu-Ching Chou, Pi-Kai Chang, Chia-Cheng Wen, Shu-Wen Jao, Hsin-Hui Huang, Yi-Hsuan Tsai, Tun-Wen Pai
  Genes.2021; 12(10): 1539.     CrossRef
• Plausibility of an extensive use of stool DNA test for screening advanced colorectal neoplasia
  Jiayi Mu, Yanqin Huang, Shanrong Cai, Qilong Li, Yongmao Song, Ying Yuan, Suzhan Zhang, Shu Zheng
  Clinica Chimica Acta.2020; 501: 42.     CrossRef
• Epigenetics of colorectal cancer: biomarker and therapeutic potential
  Gerhard Jung, Eva Hernández-Illán, Leticia Moreira, Francesc Balaguer, Ajay Goel
  Nature Reviews Gastroenterology & Hepatology.2020; 17(2): 111.     CrossRef
• Novel biomarkers for the diagnosis and prognosis of colorectal cancer
  Hyung-Hoon Oh, Young-Eun Joo
  Intestinal Research.2020; 18(2): 168.     CrossRef
• Fecal DNA methylation markers for detecting stages of colorectal cancer and its precursors: a systematic review
  Janhavi R. Raut, Zhong Guan, Petra Schrotz-King, Hermann Brenner
  Clinical Epigenetics.2020;[Epub]     CrossRef
• Hypermethylated Promoters of Secreted Frizzled-Related Protein Genes are Associated with Colorectal Cancer
  Haochang Hu, Tiangong Wang, Ranran Pan, Yong Yang, Bin Li, Cong Zhou, Jun Zhao, Yi Huang, Shiwei Duan
  Pathology & Oncology Research.2019; 25(2): 567.     CrossRef
• BMP3 promoter hypermethylation in plasma-derived cell-free DNA in colorectal cancer patients
  Parisa Rokni, Afsaneh Mojtabanezhad Shariatpanahi, Ebrahim Sakhinia, Mohammad Amin Kerachian
  Genes & Genomics.2018; 40(4): 423.     CrossRef
• Syndecan-2 Methylation as a New Biomarker for Early Detection of Colorectal Neoplasm
  Ji Hyun Kim, Sung Chul Park
  Gut and Liver.2018; 12(5): 479.     CrossRef

Citations

Citations to this article as recorded by  

• Cold EMR vs. Hot EMR for the removal of sessile serrated polyps larger than 10 mm: a systematic review and meta-analysis
  Cong Ding, Jian-feng Yang, Xia Wang, Yi-feng Zhou, Hayat Khizar, Zheng Jin, Xiao-feng Zhang
  BMC Surgery.2024;[Epub]     CrossRef
• Cold Versus Hot Endoscopic Mucosal Resection for Sessile Serrated Colorectal Polyps ≥10 mm
  Talia F. Malik, Babu P. Mohan, Smit Deliwala, Lena L. Kassab, Saurabh Chandan, Neil R. Sharma, Douglas G. Adler
  Journal of Clinical Gastroenterology.2023;[Epub]     CrossRef
• Does precutting prior to endoscopic piecemeal resection of large colorectal neoplasias reduce local recurrence? A KASID multicenter study
  Hong Jin Yoon, Dae Kyung Sohn, Yunho Jung, Hyun Seok Lee, Hoon Sup Koo, Kyeong Ok Kim, Jeong Eun Shin, Hyun Gun Kim, Il Kwun Chung, Young Hwangbo
  Surgical Endoscopy.2022; 36(5): 3433.     CrossRef
• Adenoma Recurrence after Endoscopic Piecemeal Mucosal Resection of Colorectal Flat Lesions: Applicability of the Sydney EMR Recurrence Tool in a Non-Tertiary Centre
  Maria Azevedo Silva, Carina Leal, André Ruge, Alexandra Fernandes, Liliana Eliseu, Helena Vasconcelos
  GE - Portuguese Journal of Gastroenterology.2022; 29(4): 247.     CrossRef
• Management of the malignant colorectal polyp
  Matthew Symer, James Connolly, Heather Yeo
  Current Problems in Surgery.2022; 59(5): 101124.     CrossRef
• Risk factors for local recurrence of large gastrointestinal lesions after endoscopic mucosal resection
  Yasar Colak, Badar Hasan, Walid Hassaballa, Mamoon Ur Rashid, Victor Strassmann, Giovanna DaSilva, Steven D. Wexner, Tolga Erim
  Techniques in Coloproctology.2022; 26(7): 545.     CrossRef
• Cost of Endoscopic Submucosal Dissection Versus Endoscopic Piecemeal Mucosal Resection in the Colorectum
  Nam Seok Ham, Jeongseok Kim, Eun Hye Oh, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Seung-Jae Myung, Suk-Kyun Yang, Jeong-Sik Byeon
  Digestive Diseases and Sciences.2020; 65(4): 969.     CrossRef
• Clinical outcomes of submucosal colorectal cancer diagnosed after endoscopic resection: a focus on the need for surgery
  Yun Sik Choi, Wan Soo Kim, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Seung-Jae Myung, Suk-Kyun Yang, Jeong-Sik Byeon
  Intestinal Research.2020; 18(1): 96.     CrossRef
• Efficacy and Safety of Endoscopic Resection of Sessile Serrated Polyps 10 mm or Larger: A Systematic Review and Meta-Analysis
  Viveksandeep Thoguluva Chandrasekar, Muhammad Aziz, Harsh K. Patel, Naaz Sidhu, Abhiram Duvvuri, ChandraShekhar Dasari, Kevin F. Kennedy, Ashwini Ashwath, Marco Spadaccini, Madhav Desai, Ramprasad Jegadeesan, Anjana Sathyamurthy, Prashanth Vennalaganti, D
  Clinical Gastroenterology and Hepatology.2020; 18(11): 2448.     CrossRef
• Cold snare piecemeal EMR of large sessile colonic polyps ≥20 mm (with video)
  Dileep Mangira, Karla Cameron, Koen Simons, Simon Zanati, Richard LaNauze, Spiro Raftopoulos, Gregor Brown, Alan Moss
  Gastrointestinal Endoscopy.2020; 91(6): 1343.     CrossRef

Citations

Citations to this article as recorded by  

• Short-term and residential exposure to air pollution: Associations with inflammatory biomarker levels in adults living in northern France
  Marion Darras-Hostens, Djamal Achour, Manon Muntaner, Céline Grare, Gianni Zarcone, Guillaume Garçon, Philippe Amouyel, Farid Zerimech, Régis Matran, Jean-Marc Lo Guidice, Luc Dauchet
  Science of The Total Environment.2022; 833: 154985.     CrossRef
• Functional Plasmon-Activated Water Increases Akkermansia muciniphila Abundance in Gut Microbiota to Ameliorate Inflammatory Bowel Disease
  Chun-Chao Chang, Chih-Yi Liu, I-Chia Su, Yuarn-Jang Lee, Hsing-Jung Yeh, Wen-Chao Chen, Chih-Jui Yu, Wei-Yu Kao, Yu-Chuan Liu, Chi-Jung Huang
  International Journal of Molecular Sciences.2022; 23(19): 11422.     CrossRef
• Self-reported Metabolic Risk Factor Associations with Adenomatous, Sessile Serrated, and Synchronous Adenomatous and Sessile Serrated Polyps
  Celina N. Santiago, Samara Rifkin, Julia Drewes, Gerard Mullin, Emma Spence, Linda M. Hylind, Joell J. Gills, David Kafonek, David M. Cromwell, Louis La Luna, Francis Giardello, Cynthia L. Sears
  Cancer Prevention Research.2021; 14(7): 697.     CrossRef
• Single‐incision laparoscopic colectomy for ascending colon tumor with relapsing polychondritis
  Ryugo Teranishi, Norikatsu Miyoshi, Kansuke Kido, Masayuki Nishide, Shiki Fujino, Takayuki Ogino, Hidekazu Takahashi, Mamoru Uemura, Chu Matsuda, Tsunekazu Mizusima, Masaki Mori, Yuichiro Doki
  Asian Journal of Endoscopic Surgery.2020; 13(4): 569.     CrossRef
• Increased Th17-Related Cytokine Serum Levels in Patients With Multiple Polyps of Unexplained Origin
  Miren Alustiza, Eva Hernández-Illán, Miriam Juárez, Mar Giner-Calabuig, Cristina Mira, Alejandro Martínez-Roca, Luis Bujanda, Francisco Rodríguez-Moranta, Joaquín Cubiella, Luisa de-Castro, José-Carlos Marín-Gabriel, Alberto Herreros-de-Tejada, Fernando F
  Clinical and Translational Gastroenterology.2020; 11(3): e00143.     CrossRef

Citations

Citations to this article as recorded by  

• Cryptogenic multifocal ulcerous stenosing enteritis: A ray of light on the umbra of the dark continent
  Mithu Bhowmick, Vishal Sharma
  Indian Journal of Gastroenterology.2024;[Epub]     CrossRef
• Ileal endometriosis: a rare cause of multifocal small bowel strictures
  Timothy Peacock, William Harrison, Alexandra Limmer, Suzanne Di Sano, King‐Sang Wong
  ANZ Journal of Surgery.2022; 92(7-8): 1914.     CrossRef
• Infectious diseases affecting the small bowel – what not to miss
  Martin Keuchel, Marc Bota, Peter Baltes
  Current Opinion in Gastroenterology.2021; 37(3): 255.     CrossRef
• Small bowel ulcers
  Martin Keuchel, Niehls Kurniawan, Peter Baltes
  Current Opinion in Gastroenterology.2019; 35(3): 213.     CrossRef
• Rebleeding rate and risk factors in nonsteroidal anti‐inflammatory drug‐induced enteropathy
  Junseok Park, Seong Ran Jeon, Jin‐Oh Kim, Hyun Gun Kim, Tae Hee Lee, Jun‐Hyung Cho, Bong Min Ko, Joon Seong Lee, Moon Sung Lee
  Journal of Digestive Diseases.2018; 19(5): 279.     CrossRef

Anti-tumor necrosis factor (anti-TNF) is highly effective in inflammatory bowel disease (IBD); however, it is associated with an increased risk of infections, particularly in older adults. We reviewed 349 patients with IBD, who were observed over a 12-month period, 74 of whom had received anti-TNF therapy (71 patients were aged <60 years and 3 were aged ≥60 years). All the 3 older patients developed serious infectious complications after receiving anti-TNFs, although all of them were also on concomitant immunosuppressive therapy. One patient developed disseminated tuberculosis, another patient developed cholera diarrhea followed by nosocomial pneumonia, while the third patient developed multiple opportunistic infections (Pneumocystis pneumonia, cryptococcal septicemia and meningitis, Klebsiella septicemia). All 3 patients died within 1 year from the onset of the infection(s). We recommend that anti-TNF, especially when combined with other immunosuppressive therapy, should be used with extreme caution in older adult patients with IBD.

Citations

Citations to this article as recorded by  

• RATE OF INFECTION (TUBERCULOSIS) IN BRAZILIANS IBD PRIVATE PATIENTS: FOLLOW-UP 15 YEARS
  Didia B CURY, Liana C B CURY, Ana C MICHELETTI, Rogério A OLIVEIRA, José J S GONÇALVES
  Arquivos de Gastroenterologia.2024;[Epub]     CrossRef
• Cryptococcosis Associated With Biologic Therapy: A Narrative Review
  Xin Li, Olivier Paccoud, Koon-Ho Chan, Kwok-Yung Yuen, Romain Manchon, Fanny Lanternier, Monica A Slavin, Frank L van de Veerdonk, Tihana Bicanic, Olivier Lortholary
  Open Forum Infectious Diseases.2024;[Epub]     CrossRef
• Inflammatory bowel disease complicated with rare pathogen infection
  Jia-Heng Fang, Guo-Xiong Li
  World Chinese Journal of Digestology.2023; 31(1): 8.     CrossRef
• Pulmonary cryptococcosis after immunomodulator treatment in patients with Crohn’s disease: Three case reports
  Yan-Fei Fang, Xiang-Han Cao, Ling-Ya Yao, Qian Cao
  World Journal of Gastroenterology.2023; 29(4): 758.     CrossRef
• Systemic lupus erythematosus complicated by Crohn’s disease with rectovaginal fistula
  Heng Yeh, Ren-Chin Wu, Wen-Sy Tsai, Chia-Jung Kuo, Ming-Yao Su, Cheng-Tang Chiu, Puo-Hsien Le
  BMC Gastroenterology.2021;[Epub]     CrossRef
• Systematic review with meta‐analysis: biologics and risk of infection or cancer in elderly patients with inflammatory bowel disease
  Daniele Piovani, Silvio Danese, Laurent Peyrin‐Biroulet, Georgios K. Nikolopoulos, Stefanos Bonovas
  Alimentary Pharmacology & Therapeutics.2020; 51(9): 820.     CrossRef
• Safety of Biologic Therapy in Older Patients With Immune-Mediated Diseases: A Systematic Review and Meta-analysis
  Nienke Z. Borren, Ashwin N. Ananthakrishnan
  Clinical Gastroenterology and Hepatology.2019; 17(9): 1736.     CrossRef
• Improving Quality in the Care of Patients with Inflammatory Bowel Diseases
  Matthew D Egberg, Ajay S Gulati, Ziad F Gellad, Gil Y Melmed, Michael D Kappelman
  Inflammatory Bowel Diseases.2018; 24(8): 1660.     CrossRef

Oral 5-aminosalicylic acid agents (mesalazine and sulfasalazine) and azathioprine are the mainstays of treatment for inflammatory bowel disease. Reports of pulmonary toxicity induced by oral 5-aminosalicylic acid agents or azathioprine in patients with inflammatory bowel disease are very rare; to date, only 38 cases have been reported worldwide. We, herein, report a case involving a 26-year-old man who was diagnosed with eosinophilic pneumonia after using mesalazine and azathioprine for the treatment of Crohn's disease and recovered after treatment. We also found that the fraction of exhaled nitric oxide level was elevated in this patient. After treatment, the fraction of exhaled nitric oxide level decreased and the symptoms improved. The present case shows that fraction of exhaled nitric oxide is related to the disease activity and treatment effectiveness of druginduced eosinophilic pneumonia.

Citations

Citations to this article as recorded by  

• Qualitative and quantitative study of intermolecular weak interactions for aminosalicylic acid isomers by terahertz spectroscopy
  Yuan Tang, Zhi Li, Shan Tu, Yulai She, Yongying Gan
  International Journal of Quantum Chemistry.2022;[Epub]     CrossRef
• Spontaneous resolution of focal eosinophilic myositis of the adductor pollicis complicated by lung lesions
  Sayuri Yamashita, Hidenaga Kawasumi, Makiko Kimura, Mutsuto Tateishi
  Modern Rheumatology Case Reports.2020; 4(1): 106.     CrossRef
• lncRNACNN3-206 activates intestinal epithelial cell apoptosis and invasion by sponging miR-212, an implication for Crohn's disease
  Na Li, Rui-Hua Shi
  World Journal of Gastroenterology.2020; 26(5): 478.     CrossRef
• Expression alteration of long non-coding RNAs and their target genes in the intestinal mucosa of patients with Crohn’s disease
  Na Li, Ruihua Shi
  Clinica Chimica Acta.2019; 494: 14.     CrossRef
• Mesalazin-induced eosinophilic pneumonia in a 15-year-old boy with ulcerative colitis
  G. N. Yankinа, L. V. Gorlenko, E. V. Loshkova, E. I. Kondratyeva, E. Yu. Tuteva, A. A. Terenteva, V. A. Zhelev, E. V. Mikhalev, T. A. Shemyakinа, T. S. Krivonogova, N. A. Ryzhakova, E. V. Romanova
  Bulletin of Siberian Medicine.2019; 18(3): 245.     CrossRef
• Oxidative Stress and Effect of Treatment on the Oxidation Product Decomposition Processes in IBD
  Ewa Dudzińska, Magdalena Gryzinska, Katarzyna Ognik, Paulina Gil-Kulik, Janusz Kocki, Vladimir Jakovljevic
  Oxidative Medicine and Cellular Longevity.2018;[Epub]     CrossRef

Extracolonic involvement of the gastrointestinal tract is extremely uncommon in ulcerative colitis (UC) and rarely found in the upper gastrointestinal tract or in postoperative cases since it typically responds to steroids. Here we report a case of UC complicated by extensive ileal inflammation that was refractory to steroids. A 20-year-old man was diagnosed with UC of typical pancolitis without ileal involvement and started treatment with pH-dependent mesalazine and oral prednisolone. Although his symptoms transiently resolved, the condition flared when the steroid dose was tapered down. Computed tomography revealed marked thickening of the ileal wall, and capsule endoscopy and balloon-assisted enteroscopy found diffuse mucosal inflammation with ulcers in the ileum. On the contrary, the inflammation in the colon and rectum was improving. Since the response to the second steroid course was inadequate, treatment with adalimumab and 6-mercaptopurine was initiated and finally achieved clinical and endoscopic remission. The investigation of small intestinal lesions is necessary in patients with UC whose clinical deterioration cannot be explained by colonic lesions.

Citations

Citations to this article as recorded by  

• Clinical Features and Therapeutic Outcomes of Post-colectomy Enteritis with Ulcerative Colitis
  Yuki Horio, Motoi Uchino, Kazutoshi Hori, Kurando Kusunoki, Tomohiro Minagawa, Ryuichi Kuwahara, Kozo Kataoka, Naohito Beppu, Masataka Ikeda, Hiroki Ikeuchi
  Journal of the Anus, Rectum and Colon.2021; 5(4): 405.     CrossRef

Celiac disease (CD) is an immune-mediated enteropathy and is a rare disease in Asia, including in Korea. However, the ingestion of wheat products, which can act as a precipitating factor of CD, has increased rapidly. CD is a common cause of malabsorption, but many patients can present with various atypical manifestations as first presented symptoms, including anemia, osteopenia, infertility, and neurological symptoms. Thus, making a diagnosis is challenging. We report a case of CD that mimicked amyotrophic lateral sclerosis (ALS). The patient was a sexagenary man with a history of progressive motor weakness for 2 years. He was highly suspected as having ALS. During evaluation of his neurological symptoms, esophagogastroduodenoscopy (EGD) was performed because he had experienced loose stools and weight loss for the previous 7 months. On EGD, the duodenal mucosa appeared smooth. A biopsy revealed severe lymphoplasma cell infiltration with flattened villi. His serum endomysial antibody (immunoglobulin A) titer was 1:160 (reference, <1:40). Finally, he was diagnosed as having CD, and a gluten-free diet was immediately begun. At a 4-month follow-up, his weight and the quality of his stool had improved gradually, and the neurological manifestations had not progressed.

Citations

Citations to this article as recorded by  

• Celiac disease - a pluripathological model in pediatric practice
  Vasile Valeriu Lupu, Maria Oana Sasaran, Elena Jechel, Iuliana Magdalena Starcea, Ileana Ioniuc, Adriana Mocanu, Solange Tamara Rosu, Valentin Munteanu, Alin Horatiu Nedelcu, Ciprian Danielescu, Delia Lidia Salaru, Anton Knieling, Ancuta Lupu
  Frontiers in Immunology.2024;[Epub]     CrossRef
• The presence and clinical significance of autoantibodies in amyotrophic lateral sclerosis: a narrative review
  Shen Liu, Ye Hong, Bian-Rong Wang, Zi-Qiao Wei, Hong-Dong Zhao, Teng Jiang, Ying-Dong Zhang, Jian-Quan Shi
  Neurological Sciences.2024; 45(9): 4133.     CrossRef
• Celiac Disease Genetics, Pathogenesis, and Standard Therapy for Japanese Patients
  Tasuku Tamai, Kenji Ihara
  International Journal of Molecular Sciences.2023; 24(3): 2075.     CrossRef
• A Gut Feeling in Amyotrophic Lateral Sclerosis: Microbiome of Mice and Men
  Sarah Martin, Carolina Battistini, Jun Sun
  Frontiers in Cellular and Infection Microbiology.2022;[Epub]     CrossRef
• Protective role of IGF-1 and GLP-1 signaling activation in neurological dysfunctions
  Sonalika Bhalla, Sidharth Mehan, Andleeb Khan, Muneeb U. Rehman
  Neuroscience & Biobehavioral Reviews.2022; 142: 104896.     CrossRef
• Target Metabolites to Slow Down Progression of Amyotrophic Lateral Sclerosis in Mice
  Destiny Ogbu, Yongguo Zhang, Katerina Claud, Yinglin Xia, Jun Sun
  Metabolites.2022; 12(12): 1253.     CrossRef
• Total serum immunoglobulin A in ALS
  Jesse Crayle, Mai Elmallah, John Sleasman, Richard Bedlack
  Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration.2021; 22(1-2): 61.     CrossRef
• Underutilization of diagnostic assays for celiac disease in Korea
  Rihwa Choi, Sang Gon Lee, Eun Hee Lee
  Journal of Clinical Laboratory Analysis.2021;[Epub]     CrossRef
• Aberrant enteric neuromuscular system and dysbiosis in amyotrophic lateral sclerosis
  Yongguo Zhang, Destiny Ogbu, Shari Garrett, Yinglin Xia, Jun Sun
  Gut Microbes.2021;[Epub]     CrossRef
• Premalignant Lesions of the Small Intestine
  Su Hwan Kim, Ji Won Kim
  Journal of Digestive Cancer Reports.2021; 9(2): 60.     CrossRef
• The effects of diet and sex in amyotrophic lateral sclerosis
  J.A. Pape, J.H. Grose
  Revue Neurologique.2020; 176(5): 301.     CrossRef
• “ALS reversals”: demographics, disease characteristics, treatments, and co-morbidities
  Daniel Harrison, Paul Mehta, Michael A. van Es, Elijah Stommel, Vivian E. Drory, Beatrice Nefussy, Leonard H. van den Berg, Jesse Crayle, Richard Bedlack
  Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration.2018; 19(7-8): 495.     CrossRef

Citations

Citations to this article as recorded by  

• Prediction of treatment outcome and relapse in inflammatory bowel disease
  Jun Kato, Takeichi Yoshida, Sakiko Hiraoka
  Expert Review of Clinical Immunology.2019; 15(6): 667.     CrossRef

Citations

Citations to this article as recorded by  

• Various Endoscopic Features in Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma
  Yasuhiro Aoki, Tomohisa Sujino, Kaoru Takabayashi, Makoto Mutakuchi, Katsura Emoto, Naoki Hosoe, Haruhiko Ogata, Takanori Kanai
  Case Reports in Gastroenterology.2021; 15(1): 312.     CrossRef
• Gastrointestinal Presentations of Common Variable Immunodeficiency: Hiding in Plain Sight
  Oluwatobi Odetola, Vijayalakshmi Ananthanarayanan
  Archives of Pathology & Laboratory Medicine.2019; 143(4): 525.     CrossRef

Citations

Citations to this article as recorded by  

• Colorectal cancer screening guidelines for average-risk and high-risk individuals: A systematic review
  Caroline Tanadi, Kevin Tandarto, Maureen Miracle Stella, Kenny Wijaya Sutanto, Mario Steffanus, Riki Tenggara, Muhammad Begawan Bestari
  Romanian Journal of Internal Medicine.2024; 62(2): 101.     CrossRef
• Prevalence and risk of colorectal polyps among the Korean population under 50 years
  Su Jin Jeong, Jinho Lee, Eunju Kim, Jun Seong Hwang, Jin Lee, Joon Hyuk Choi, Nae-Yun Heo, Jongha Park, Seung Ha Park, Tae Oh Kim, Yong Eun Park
  Medicine.2022; 101(27): e29493.     CrossRef
• Optimization of the surveillance strategy in patients with colorectal adenomas: A combination of clinical parameters and index colonoscopy findings
  Chan Hyuk Park, Yoon Suk Jung, Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn
  Journal of Gastroenterology and Hepatology.2021; 36(4): 974.     CrossRef
• Colorectal Cancer among Resettlers from the Former Soviet Union and in the General German Population: Clinical and Pathological Characteristics and Trends
  Melani Ratih Mahanani, Simone Kaucher, Hiltraud Kajüter, Bernd Holleczek, Heiko Becher, Volker Winkler
  International Journal of Environmental Research and Public Health.2021; 18(9): 4547.     CrossRef
• Association between waist circumference and risk of colorectal neoplasia in normal‐weight adults
  Yoon Suk Jung, Nam Hee Kim, Hyo‐Joon Yang, Soo‐Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn
  Journal of Gastroenterology and Hepatology.2020; 35(1): 43.     CrossRef
• Prevalence of and Risk Factors for Colorectal Neoplasia in Asymptomatic Young Adults (20–39 Years Old)
  Nam Hee Kim, Yoon Suk Jung, Hyo-Joon Yang, Soo-Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn
  Clinical Gastroenterology and Hepatology.2019; 17(1): 115.     CrossRef
• Impact of family history of colorectal cancer on age‐specific prevalence of colorectal neoplasia
  Chan Hyuk Park, Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Yoon Suk Jung
  Journal of Gastroenterology and Hepatology.2019; 34(3): 537.     CrossRef
• Frequency of I655V SNP of HER-2/neu in colorectal cancer: a study from India
  Rameez Hasan, Deepti Bhatt, Shahbaz Khan, Vasiuddin Khan, Amit Kumar Verma, Prahalad Singh Bharti, Afzal Anees, Kapil Dev
  3 Biotech.2019;[Epub]     CrossRef
• Appropriate Surveillance Interval after Colonoscopic Polypectomy in Patients Younger than 50 Years
  Yoon Suk Jung, Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn
  Journal of Korean Medical Science.2019;[Epub]     CrossRef
• Analysis of population‐based colorectal cancer screening in Guangzhou, 2011‐2015
  Feng Zhiqiang, Cao Jie, Nie Yuqiang, Gong Chenghua, Wang Hong, Sun Zheng, Li Wanglin, Zhou Yongjian, Dai Liping, Zeng Lizhong, Zhao DeJian
  Cancer Medicine.2019; 8(5): 2496.     CrossRef
• Risk of Developing Metachronous Advanced Colorectal Neoplasia After Polypectomy in Patients With Multiple Diminutive or Small Adenomas
  Nam Hee Kim, Yoon Suk Jung, Mi Yeon Lee, Jung Ho Park, Dong Il Park, Chong Il Sohn
  American Journal of Gastroenterology.2019; 114(10): 1657.     CrossRef
• Association between family history of colorectal cancer and the risk of metachronous colorectal neoplasia following polypectomy in patients aged < 50 years
  Nam Hee Kim, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
  Journal of Gastroenterology and Hepatology.2019; 34(2): 383.     CrossRef
• Adenoma Detection before and after the age of 50: a retrospective analysis of Lebanese outpatients
  Mohammed Hussein Kamareddine, Youssef Ghosn, Karam Karam, Anwar Andrew Nader, Ahmad El-Mahmoud, Naseem Bou-Ayash, Mansour El-Khoury, Said Farhat
  BMJ Open Gastroenterology.2018; 5(1): e000253.     CrossRef
• Optimal Starting Age for Colorectal Cancer Screening in an Era of Increased Metabolic Unhealthiness: A Nationwide Korean Cross-Sectional Study
  Yoon Jin Choi, Dong Ho Lee, Kyung-Do Han, Hyun Soo Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim
  Gut and Liver.2018; 12(6): 655.     CrossRef

Citations

Citations to this article as recorded by  

• Risk factors affecting failure of colonoscopic detorsion for sigmoid colon volvulus: a single center experience
  Ahmet Surek, Cevher Akarsu, Eyup Gemici, Sina Ferahman, Ahmet Cem Dural, Mehmet Abdussamet Bozkurt, Turgut Donmez, Mehmet Karabulut, Halil Alis
  International Journal of Colorectal Disease.2021; 36(6): 1221.     CrossRef
• Author's Reply
  Tomoya Iida, Hiroyuki Kaneto, Hiroshi Nakase
  Intestinal Research.2017; 15(4): 554.     CrossRef