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Volume 17(3); July 2019
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Editorial
IBD
Subcutaneous integrin inhibitors may provide more treatment options for patients with moderate-to-severe ulcerative colitis
Hyuk Yoon
Intest Res 2019;17(3):283-284.   Published online July 25, 2019
DOI: https://doi.org/10.5217/ir.2019.00070
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IBD
Best practices on immunomodulators and biologic agents for ulcerative colitis and Crohn’s disease in Asia
Choon Jin Ooi, Ida Hilmi, Rupa Banerjee, Sai Wei Chuah, Siew Chien Ng, Shu Chen Wei, Govind K Makharia, Pises Pisespongsa, Min Hu Chen, Zhi Hua Ran, Byong Duk Ye, Dong Il Park, Khoon Lin Ling, David Ong, Vineet Ahuja, Khean Lee Goh, Jose Sollano, Wee Chian Lim, Wai Keung Leung, Raja Affendi Raja Ali, Deng Chyang Wu, Evan Ong, Nazri Mustaffa, Julajak Limsrivilai, Tadakazu Hisamatsu, Suk Kyun Yang, Qin Ouyang, Richard Geary, Janaka H De Silva, Rungsun Rerknimitr, Marcellus Simadibrata, Murdani Abdullah, Rupert WL Leong, the Asia Pacific Association of Gastroenterology (APAGE) Working Group on Inflammatory Bowel Disease and Asian Organization for Crohn’s and Colitis
Intest Res 2019;17(3):285-310.   Published online May 31, 2019
DOI: https://doi.org/10.5217/ir.2019.00026
AbstractAbstract PDFPubReaderePub
The Asia-Pacific Working Group on inflammatory bowel disease (IBD) was established in Cebu, Philippines, under the auspices of the Asian Pacific Association of Gastroenterology with the goal of improving IBD care in Asia. This consensus is carried out in collaboration with Asian Organization for Crohn’s and Colitis. With biologic agents and biosimilars becoming more established, it is necessary to conduct a review on existing literature and establish a consensus on when and how to introduce biologic agents and biosimilars in the conjunction with conventional treatments for ulcerative colitis (UC) and Crohn’s disease (CD) in Asia. These statements also address how pharmacogenetics influence the treatments of UC and CD and provide guidance on response monitoring and strategies to restore loss of response. Finally, the review includes statements on how to manage treatment alongside possible hepatitis B and tuberculosis infections, both common in Asia. These statements have been prepared and voted upon by members of IBD workgroup employing the modified Delphi process. These statements do not intend to be all-encompassing and future revisions are likely as new data continue to emerge.

Citations

Citations to this article as recorded by  
  • Progress on the mechanisms of Lactobacillus plantarum to improve intestinal barrier function in ulcerative colitis
    Yihui Liu, Gang Liu, Jun Fang
    The Journal of Nutritional Biochemistry.2024; 124: 109505.     CrossRef
  • Therapeutic Drug Monitoring in Patients with Systemic Lupus Erythematosus: Utility and Gaps
    Kar Mun Chong, He Jiang, Elaine Ah Gi Lo, Wei-Zhen Hong, Emmett Tsz-Yeung Wong, Gek Cher Chan, Jiacai Cho
    Journal of Clinical Medicine.2024; 13(2): 451.     CrossRef
  • Modified Gegen Qinlian Decoction Ameliorates DSS-Induced Ulcerative Colitis in Mice by Inhibiting Ferroptosis via Nrf2/GPX4 Pathway
    Jinke Huang, Jiaqi Zhang, Zhihong Liu, Jing Ma, Fengyun Wang, Xudong Tang, Muhammad Babar Khawar
    Journal of Food Quality.2024; 2024: 1.     CrossRef
  • Ten missteps in the management of inflammatory bowel disease in Asia: An expert report by the Asian Pacific Association of Gastroenterology Working Group on Inflammatory Bowel Disease
    Vineet Ahuja, Ida Hilmi, Byong Duk Ye, Khoon Lin Ling, Siew C. Ng, Rupert W. Leong, Peeyush Kumar, Xin Hui Khoo, Govind K. Makharia, Jose Sollano, Pises Pisespongsa, Nazri Mustaffa, Rupa Banerjee, Alex Hwong‐Ruey Leow, Raja Affendi Raja Ali, Sai Wei Chuah
    Journal of Gastroenterology and Hepatology.2024; 39(8): 1500.     CrossRef
  • Risk Factors of Pneumocystis jirovecii Pneumonia in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Study
    Jiyoung Yoon, Seung Wook Hong, Kyung-Do Han, Seung-Woo Lee, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Joo Sung Kim, Hyuk Yoon
    Gut and Liver.2024; 18(3): 489.     CrossRef
  • Modified Gegen Qinlian Decoction modulated the gut microbiome and bile acid metabolism and restored the function of goblet cells in a mouse model of ulcerative colitis
    Jinke Huang, Jiaqi Zhang, Fengyun Wang, Xudong Tang
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Pharmacogenetics in personalized treatment in pediatric patients with inflammatory bowel disease (IBD)
    Daniela Kosorínová, Pavlína Suchá, Zuzana Havlíčeková, Marek Pršo, Pavol Dvoran, Peter Bánovčin
    Česko-slovenská pediatrie.2024; 79(4): 213.     CrossRef
  • Real‐world experience of adalimumab therapy for patients with ulcerative colitis: A single tertiary medical center experience in Central Taiwan
    Hsu‐Heng Yen, Yu‐Chun Hsu, Chu‐Hsuan Kuo, Tsui‐Chun Hsu, Yang‐Yuan Chen
    Advances in Digestive Medicine.2023; 10(1): 28.     CrossRef
  • A Retrospective Cohort Study of Clinical Features and Treatment Patterns With Ustekinumab in Patients With Crohn Disease Utilizing a Health Care Database in Japan
    Yanfang Liu, Choo Hua Goh, Hong Qiu, Kuan-Chih Huang, Hsingwen Chung, Carine Saadoun
    Annals of Pharmacotherapy.2023; 57(9): 1053.     CrossRef
  • Compositional changes in fecal microbiota associated with clinical phenotypes and prognosis in Korean patients with inflammatory bowel disease
    Seung Yong Shin, Young Kim, Won-Seok Kim, Jung Min Moon, Kang-Moon Lee, Sung-Ae Jung, Hyesook Park, Eun Young Huh, Byung Chang Kim, Soo Chan Lee, Chang Hwan Choi
    Intestinal Research.2023; 21(1): 148.     CrossRef
  • Optimización del tratamiento de la colitis ulcerosa leve a moderada: Consenso Delphi CU-Forum
    Miquel Sans Cuffi, Federico Argüelles Arias, Ana Echarri Piudo, Daniel Ginard Vicens, Ana Gutiérrez Casbas, Ignacio Marín-Jiménez
    Gastroenterología y Hepatología.2023; 46(10): 784.     CrossRef
  • Study on the anti‐inflammatory effect of stachyose by inhibiting TLR4/NF‐κB signalling pathway in vitro and in vivo
    Songsong Jiang, Qian Li, Shiwen Han, Hengpeng Wang, Xinlei Tang, Tao Wang, Xiangren Meng
    Clinical and Experimental Pharmacology and Physiology.2023; 50(7): 573.     CrossRef
  • Physiologically‐Based Pharmacokinetic Modeling of Anti‐Tumor Necrosis Factor Agents for Inflammatory Bowel Disease Patients to Predict the Withdrawal Time in Pregnancy and Vaccine Time in Infants
    Jiarui Chen, Rongfang Lin, Guimu Guo, Wanhong Wu, Meng Ke, Chengjie Ke, Pinfang Huang, Cuihong Lin
    Clinical Pharmacology & Therapeutics.2023; 114(6): 1254.     CrossRef
  • Optimizing treatment of mild to moderate ulcerative colitis: CU-forum Delphi consensus
    Miquel Sans Cuffi, Federico Argüelles Arias, Ana Echarri Piudo, Daniel Ginard Vicens, Ana Gutiérrez Casbas, Ignacio Marín-Jiménez
    Gastroenterología y Hepatología (English Edition).2023; 46(10): 784.     CrossRef
  • Diagnosis of Crohn’s disease and ulcerative colitis using the microbiome
    Da-Yeon Kang, Jong-Lyul Park, Min-Kyung Yeo, Sang-Bum Kang, Jin-Man Kim, Ju Seok Kim, Seon-Young Kim
    BMC Microbiology.2023;[Epub]     CrossRef
  • IBD barriers across the continents – East Asia
    Joyce Wing Yan Mak, Agnes Hiu Yan Ho, Siew Chien Ng
    Therapeutic Advances in Gastroenterology.2023;[Epub]     CrossRef
  • Clinical Features and Long-Term Outcomes of Paediatric-Onset Inflammatory Bowel Disease in a Population-Based Cohort in the Songpa-Kangdong District of Seoul, Korea
    Sang Hyoung Park, Jong Pil Im, Hyunju Park, Seung Kyu Jeong, Ji Hyun Lee, Kyoung Hoon Rhee, Young-Ho Kim, Sung Noh Hong, Kyung Ho Kim, Seung In Seo, Jae Myung Cha, Sun Yong Park, Joo Sung Kim, Hyuk Yoon, Sung Hoon Kim, Jisun Jang, Jeong Hwan Kim, Seong O
    Journal of Crohn's and Colitis.2022; 16(2): 207.     CrossRef
  • Association between Fecal Calprotectin and Mucosal Healing in Pediatric Patients with Crohn’s Disease Who Have Achieved Sustained Clinical Remission with Anti-Tumor Necrosis Factor Agents
    Yoo Min Lee, Sujin Choi, Byung-Ho Choe, Hyo-Jeong Jang, Seung Kim, Hong Koh, Eun Sil Kim, Mi Jin Kim, Yon Ho Choe, Ben Kang
    Gut and Liver.2022; 16(1): 62.     CrossRef
  • Management of inflammatory bowel disease in the COVID-19 era
    Kyeong Ok Kim, Byung Ik Jang
    Intestinal Research.2022; 20(1): 3.     CrossRef
  • Long-term efficacy and tolerability of dose-adjusted thiopurine treatment in maintaining remission in inflammatory bowel disease patients with NUDT15 heterozygosity
    Takato Maeda, Hirotake Sakuraba, Hiroto Hiraga, Shukuko Yoshida, Yoichi Kakuta, Hidezumi Kikuchi, Shogo Kawaguchi, Keisuke Hasui, Tetsuya Tatsuta, Daisuke Chinda, Tatsuya Mikami, Shinsaku Fukuda
    Intestinal Research.2022; 20(1): 90.     CrossRef
  • Changes in the Long-term Prognosis of Crohn’s Disease between 1986 and 2015: The Population-Based Songpa-Kangdong Inflammatory Bowel Disease Cohort Study
    Byong Duk Ye, Sung Noh Hong, Seung In Seo, Ye-Jee Kim, Jae Myung Cha, Kyoung Hoon Rhee, Hyuk Yoon, Young-Ho Kim, Kyung Ho Kim, Sun Yong Park, Seung Kyu Jeong, Ji Hyun Lee, Hyunju Park, Joo Sung Kim, Jong Pil Im, Sung Hoon Kim, Jisun Jang, Jeong Hwan Kim,
    Gut and Liver.2022; 16(2): 216.     CrossRef
  • Emerging inflammatory bowel disease demographics, phenotype, and treatment in South Asia, South‐East Asia, and Middle East: Preliminary findings from the Inflammatory Bowel Disease‐Emerging Nations' Consortium
    Rupa Banerjee, Partha Pal, Ida Hilmi, Uday C Ghoshal, Devendra C Desai, Mohammed Masudur Rahman, Usha Dutta, Syed A Mohiuddin, Munnera Al Mohannadi, Mathew Philip, Ganesh N Ramesh, Madunil A Niriella, Arjuna P De Silva, Hithanadura Janaka de Silva, Pises
    Journal of Gastroenterology and Hepatology.2022; 37(6): 1004.     CrossRef
  • Implications of the COVID-19 Pandemic on the Management of Inflammatory Bowel Disease in the Low Resource Countries of Asia
    Partha Pal, Joyce Wing Yan Mak, Siew C Ng, Rupa Banerjee
    EMJ Gastroenterology.2022;[Epub]     CrossRef
  • The Prognostic Value of Residual Nonrectal Inflammation in Ulcerative Colitis
    Eun Ae Kang
    Gut and Liver.2022; 16(3): 487.     CrossRef
  • Indications, Postoperative Management, and Long-term Prognosis of Crohn’s Disease After Ileocecal Resection: A Multicenter Study Comparing the East and West
    Jeanine H C Arkenbosch, Joyce W Y Mak, Jacky C L Ho, Evelien M J Beelen, Nicole S Erler, Frank Hoentjen, Alexander G L Bodelier, Gerard Dijkstra, Mariëlle Romberg-Camps, Nanne K H de Boer, Laurents P S Stassen, Andrea E van der Meulen, Rachel West, Oddeke
    Inflammatory Bowel Diseases.2022; 28(Supplement): S16.     CrossRef
  • Personalized medicine in inflammatory bowel disease: Perspectives on Asia
    Su Hyun Park, Sang Hyoung Park
    Journal of Gastroenterology and Hepatology.2022; 37(8): 1434.     CrossRef
  • Antiviral Prophylaxis Against Hepatitis B Virus in Patients Treated with Anti-Tumor Necrosis Factor α Agents for Inflammatory Bowel Disease
    Eun Ae Kang, Jae Hee Cheon
    Gut and Liver.2022; 16(4): 501.     CrossRef
  • Therapeutic Drug Monitoring of Biologics for Patients with Inflammatory Bowel Diseases: How, When, and for Whom?
    Jia-Feng Wu
    Gut and Liver.2022; 16(4): 515.     CrossRef
  • Risk of Hepatitis B Virus (HBV) Reactivation in Patients with Immune-Mediated Inflammatory Diseases Receiving Biologics: Focus on the Timing of Biologics after Anti-HBV Treatment
    Soo Min Ahn, Jonggi Choi, Byong Duk Ye, Suk-Kyun Yang, Ji Seon Oh, Yong‑Gil Kim, Chang-Keun Lee, Bin Yoo, Sang Hyoung Park, Seokchan Hong
    Gut and Liver.2022; 16(4): 567.     CrossRef
  • Oral beclomethasone dipropionate as an add-on therapy and response prediction in Korean patients with ulcerative colitis
    Kyuwon Kim, Hee Seung Hong, Kyunghwan Oh, Jae Yong Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye, Sang Hyoung Park
    The Korean Journal of Internal Medicine.2022; 37(6): 1140.     CrossRef
  • Effectiveness and Safety of Golimumab in Patients with Ulcerative Colitis: A Multicenter, Prospective, Postmarketing Surveillance Study
    Jongwook Yu, Soo Jung Park, Hyung Wook Kim, Yun Jeong Lim, Jihye Park, Jae Myung Cha, Byong Duk Ye, Tae Oh Kim, Hyun-Soo Kim, Hyun Seok Lee, Su Young Jung, Youngdoe Kim, Chang Hwan Choi
    Gut and Liver.2022; 16(5): 764.     CrossRef
  • Current Status of Opportunistic Infection in Inflammatory Bowel Disease Patients in Asia: A Questionnaire-Based Multicenter Study
    Hong Yang, Zhihua Ran, Meng Jin, Jia-Ming Qian
    Gut and Liver.2022; 16(5): 726.     CrossRef
  • Natural history of inflammatory bowel disease: a comparison between the East and the West
    Eun Mi Song, Suk-Kyun Yang
    Intestinal Research.2022; 20(4): 418.     CrossRef
  • Clinical Features and Long-term Prognosis of Crohn’s Disease in Korea: Results from the Prospective CONNECT Study
    Seung Wook Hong, Byong Duk Ye, Jae Hee Cheon, Ji Hyun Lee, Ja Seol Koo, Byung Ik Jang, Kang-Moon Lee, You Sun Kim, Tae Oh Kim, Jong Pil Im, Geun Am Song, Sung-Ae Jung, Hyun Soo Kim, Dong Il Park, Hyun-Soo Kim, Kyu Chan Huh, Young-Ho Kim, Jae Myung Cha, Ge
    Gut and Liver.2022; 16(6): 907.     CrossRef
  • Early-Phase Partial Mayo Score following Golimumab Treatment Is Associated with Endoscopic Improvement at 1 Year in Ulcerative Colitis: A post hoc Analysis of PURSUIT-J Randomized Controlled Trial
    Katsumasa Nagano, Yuya Imai, Yoshifumi Ukyo, Taku Kobayashi, Seiji Yokoyama
    Inflammatory Intestinal Diseases.2022; 7(3-4): 155.     CrossRef
  • Epidemiology, burden of disease, and unmet needs in the treatment of ulcerative colitis in Asia
    Shu-Chen Wei, Jose Sollano, Yee Tak Hui, Wei Yu, Paul V. Santos Estrella, Lyndon John Q. Llamado, Nana Koram
    Expert Review of Gastroenterology & Hepatology.2021; 15(3): 275.     CrossRef
  • Mycosis fungoides in a patient with ulcerative colitis on anti-tumor necrosis factor-alpha therapy
    Takeshi Yasuda, Tomohisa Takagi, Jun Asai, Norito Katoh, Junya Kuroda, Yasumichi Kuwahara, Yukiko Morinaga, Eiichi Konishi, Kazuhiko Uchiyama, Yuji Naito, Yoshito Itoh
    Clinical Journal of Gastroenterology.2021; 14(1): 170.     CrossRef
  • Early Changes in Serum Albumin Predict Clinical and Endoscopic Outcomes in Patients With Ulcerative Colitis Starting Anti-TNF Treatment
    Sun-Ho Lee, Margaret Walshe, Eun Hye Oh, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Tomer Greener, Adam V Weizman, Mark S Silverberg, Byong Duk Ye
    Inflammatory Bowel Diseases.2021; 27(9): 1452.     CrossRef
  • Segundo Consenso Mexicano de terapia biológica y moléculas pequeñas en enfermedad inflamatoria intestinal
    J.K. Yamamoto-Furusho, F.J. Bosques-Padilla, M.A. Martínez-Vázquez
    Revista de Gastroenterología de México.2021; 86(1): 70.     CrossRef
  • Comparison of Long-term Outcomes of Infliximab versus Adalimumab in 1,488 Biologic-Naive Korean Patients with Crohn’s Disease
    Yoon Suk Jung, Minkyung Han, Sohee Park, Jae Hee Cheon
    Gut and Liver.2021; 15(1): 92.     CrossRef
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    Stem Cell Research & Therapy.2021;[Epub]     CrossRef
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    Yoon Suk Jung, Minkyung Han, Sohee Park, Jae Hee Cheon
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    Journal of Nanobiotechnology.2020;[Epub]     CrossRef
  • Challenges in the diagnosis and management of inflammatory bowel disease in resource-limited settings in Asia
    Rupa Banerjee, Partha Pal, Joyce Wing Yan Mak, Siew C Ng
    The Lancet Gastroenterology & Hepatology.2020; 5(12): 1076.     CrossRef
  • Optimising management strategies of inflammatory bowel disease in resource-limited settings in Asia
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  • NUDT15 C415T variant compared with TPMT genotyping in predicting azathioprine‐induced leucopenia: prospective analysis of 1014 inflammatory bowel disease patients in India
    Rupa Banerjee, Vishnubhotla Venkata Ravikanth, Partha Pal, Govardhan Bale, Urmila Steffie Avanthi, Idan Goren, B. Ganesh Girish, Sasikala Mitnala, D. Nageshwar Reddy
    Alimentary Pharmacology & Therapeutics.2020; 52(11-12): 1683.     CrossRef
  • 28,151 View
  • 929 Download
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Close layer
IBD
Stem cell-based therapy for inflammatory bowel disease
Hiromichi Shimizu, Kohei Suzuki, Mamoru Watanabe, Ryuichi Okamoto
Intest Res 2019;17(3):311-316.   Published online July 25, 2019
DOI: https://doi.org/10.5217/ir.2019.00043
AbstractAbstract PDFPubReaderePub
Inflammatory bowel disease (IBD) is an idiopathic, multi-etiological disease characterized by inflammation and mucosal destruction of the gastrointestinal tract. Despite the remarkable advance in immunomodulating therapies, there still remains a certain population of patients who are refractory to conventional as well as biologic therapies and fail to achieve mucosal healing. To improve the prognosis of those patients, at least 2 types of stem cells have been tested for their potential therapeutic use. Transplantation of hematopoietic stem cells or mesenchymal stem cells have been tested in several clinical studies, but their beneficial effect still remains controversial. In this review, we would like to overview the recent clinical challenges of stem cell-based therapies in IBD and also introduce our new therapeutic plan of intestinal stem cell transplantation for IBD, based on our ex vivo intestinal organoid culture technique.

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  • The nasal basal cell population shifts toward a diseased phenotype with impaired barrier formation capacity in allergic rhinitis
    Emma Ruysseveldt, Brecht Steelant, Tine Wils, Jonathan Cremer, Dominique M.A. Bullens, Peter W. Hellings, Katleen Martens
    Journal of Allergy and Clinical Immunology.2024; 154(3): 631.     CrossRef
  • Nigakinone alleviates DSS‐induced experimental colitis via regulating bile acid profile and FXR/NLRP3 signaling pathways
    Fangle Liu, Yufeng Yao, Qian Wang, Fengxue Zhang, Meiqi Wang, Chenchen Zhu, Chaozhan Lin
    Phytotherapy Research.2023; 37(1): 15.     CrossRef
  • TNFα Induces LGR5+ Stem Cell Dysfunction In Patients With Crohn’s Disease
    Chansu Lee, Minae An, Je-Gun Joung, Woong-Yang Park, Dong Kyung Chang, Young-Ho Kim, Sung Noh Hong
    Cellular and Molecular Gastroenterology and Hepatology.2022; 13(3): 789.     CrossRef
  • Bovine colostrum derived-exosomes prevent dextran sulfate sodium-induced intestinal colitis via suppression of inflammation and oxidative stress
    Geonhee Han, Haeun Cho, Hyosuk Kim, Yeongji Jang, Hochung Jang, Da Eun Kim, Eun Sun Kim, Eun Hye Kim, Kwang Yeon Hwang, Kwangmeyung Kim, Yoosoo Yang, Sun Hwa Kim
    Biomaterials Science.2022; 10(8): 2076.     CrossRef
  • The therapeutic potential of stem cell-derived exosomes in the ulcerative colitis and colorectal cancer
    Gang Guo, Zhaobang Tan, Yaping Liu, Feiyu Shi, Junjun She
    Stem Cell Research & Therapy.2022;[Epub]     CrossRef
  • Mesenchymal stem/stromal cells in the pathogenesis and regenerative therapy of inflammatory bowel diseases
    Zhengping Che, Ziyu Ye, Xueying Zhang, Bihua Lin, Weiqing Yang, Yanfang Liang, Jincheng Zeng
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Mechanotransduction through adhesion molecules: Emerging roles in regulating the stem cell niche
    Ryan Lim, Avinanda Banerjee, Ritusree Biswas, Anana Nandakumar Chari, Srikala Raghavan
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • Clinical applications and optimization of patient-derived organoids in intestinal diseases
    Tae Il Kim
    Organoid.2022; 2: e22.     CrossRef
  • Therapeutic Advances in Diabetes, Autoimmune, and Neurological Diseases
    Jinsha Liu, Joey Paolo Ting, Shams Al-Azzam, Yun Ding, Sepideh Afshar
    International Journal of Molecular Sciences.2021; 22(6): 2805.     CrossRef
  • Comparative perianal fistula closure rates following autologous adipose tissue-derived stem cell transplantation or treatment with anti-tumor necrosis factor agents after seton placement in patients with Crohn’s disease: a retrospective observational stud
    Min Young Park, Yong Sik Yoon, Jong Lyul Lee, Sang Hyoung Park, Byong Duk Ye, Suk-Kyun Yang, Chang Sik Yu
    Stem Cell Research & Therapy.2021;[Epub]     CrossRef
  • Current Trends and Research Topics Regarding Intestinal Organoids: An Overview Based on Bibliometrics
    Meng-Meng Zhang, Ke-Lu Yang, Yan-Cheng Cui, Yu-Shi Zhou, Hao-Ran Zhang, Quan Wang, Ying-Jiang Ye, Shan Wang, Ke-Wei Jiang
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • The Potential of Vitamin D3 to Repaired Mucosal Injury in Dextran Sulfate Sodium Induced Acute Colitis in Mice
    Satrio Wibowo, Krisni Subandiyah, Kusworini Handono, Sri Poeranto
    Open Access Macedonian Journal of Medical Sciences.2021; 9(B): 931.     CrossRef
  • Pharmacogenetics-based personalized treatment in patients with inflammatory bowel disease: A review
    Ji Young Chang, Jae Hee Cheon
    Precision and Future Medicine.2021; 5(4): 151.     CrossRef
  • Mutual regulation between butyrate and hypoxia‐inducible factor‐1α in epithelial cell promotes expression of tight junction proteins
    Jiuheng Yin, Chao Zhou, Kunqiu Yang, Yanbei Ren, Yuan Qiu, Pengyuan Xu, Weidong Xiao, Hua Yang
    Cell Biology International.2020; 44(6): 1405.     CrossRef
  • Letter: off‐label use of hyperbaric oxygen therapy in inflammatory bowel disease—Authors’ reply
    Melek Simsek, Nanne K. H. de Boer
    Alimentary Pharmacology & Therapeutics.2020; 52(1): 216.     CrossRef
  • The Role of Immune and Epithelial Stem Cells in Inflammatory Bowel Disease Therapy
    Agata Binienda, Sylwia Ziolkowska, Ingvild H. Hauge, Maciej Salaga
    Current Drug Targets.2020; 21(14): 1405.     CrossRef
  • 8,851 View
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  • 16 Web of Science
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Close layer
Colorectal neoplasia
Prevalence and risk factors of colorectal cancer in Asia
Martin CS Wong, Hanyue Ding, Jingxuan Wang, Paul SF Chan, Junjie Huang
Intest Res 2019;17(3):317-329.   Published online May 20, 2019
DOI: https://doi.org/10.5217/ir.2019.00021
AbstractAbstract PDFPubReaderePub
Globally, colorectal cancer (CRC) is a substantial public health burden, and it is increasingly affecting populations in Asian countries. The overall prevalence of CRC is reported to be low in Asia when compared with that in Western nations, yet it had the highest number of prevalent cases. This review described the prevalence of CRC in Asia according to the International Agency for Research on Cancer from World Health Organization (WHO) database and summarized its major risk factors. Non-modifiable factors include genetic factors, ethnicity, age, gender, family history and body height; smoking, alcohol drinking, weight, Westernized diet, physical inactivity, chronic diseases and microbiota were involved in environmental factors. These risk factors were separately discussed in this review according to published literature from Asian countries. CRC screening has been playing an important role in reducing its disease burden. Some recommendations on its screening practices have been formulated in guidelines for Asia Pacific countries.

Citations

Citations to this article as recorded by  
  • Risk factors for post-polypectomy bleeding in patients with end-stage renal disease undergoing colonoscopic polypectomy
    Jung Hyun Ji, Hyun Woo Kim, Jihye Park, Soo Jung Park, Jae Hee Cheon, Tae Il Kim, Jae Jun Park
    Surgical Endoscopy.2024; 38(2): 846.     CrossRef
  • Trends in colorectal cancer incidence according to an increase in the number of colonoscopy cases in Korea
    Ga Hee Kim, Yeong Chan Lee, Tae Jun Kim, Sung Noh Hong, Dong Kyung Chang, Young-Ho Kim, Dong-Hoon Yang, Chang Mo Moon, Kyunga Kim, Hyun Gun Kim, Eun-Ran Kim
    World Journal of Gastrointestinal Oncology.2024; 16(1): 51.     CrossRef
  • The effectiveness of physiotherapy interventions on fecal incontinence and quality of life following colorectal surgery: a systematic review and meta-analysis of randomized controlled trials
    Ming Yan Pun, Pak Ho Leung, Tsz Ching Chan, Chunn Pang, Kin Hei Chan, Priya Kannan
    Supportive Care in Cancer.2024;[Epub]     CrossRef
  • Multiethnic Trends in Early Onset Colorectal Cancer
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    Cancers.2024; 16(2): 398.     CrossRef
  • Cancer screening programs in South-east Asia and Western Pacific
    Hwee-Lin Wee, Karen Canfell, Han-Mo Chiu, Kui Son Choi, Brian Cox, Nirmala Bhoo-Pathy, Kate T Simms, Chisato Hamashima, Qianyu Shen, Brandon Chua, Niyomsri Siwaporn, Esther Toes-Zoutendijk
    BMC Health Services Research.2024;[Epub]     CrossRef
  • RETRACTED: Comparison of prediction fuzzy modeling towards high-risk symptoms of lung cancer
    Aliya Syaffa Zakaria, Muhammad Ammar Shafi, Mohd Arif Mohd Zim, Aisya Natasya Musa
    Journal of Intelligent & Fuzzy Systems.2024; 46(4): 7959.     CrossRef
  • The Association of Low-Carbohydrate Diet and HECTD4 rs11066280 Polymorphism with Risk of Colorectal Cancer: A Case-Control Study in Korea
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    Current Developments in Nutrition.2024; 8(3): 102127.     CrossRef
  • Health-related quality of life and related factors in patients with colorectal cancer in Iran: a systematic review
    Zahra Naeimabadi, Homayoon Bana Derakhshan, Maryam Rassouli, Abbas Ebadi
    Annals of Medicine & Surgery.2024; 86(4): 2088.     CrossRef
  • An App-Based Physical Activity Intervention Study in Community-Dwelling Chinese-, Tagalog-, and Vietnamese-Speaking Americans: A Pilot Study (Preprint)
    Antony Nguyen, Filmer Yu, Linda G. Park, Yoshimi Fukuoka, Ching Wong, Ginny Gildengorin, Tung T. Nguyen, Janice Y. Tsoh, Jane Jih
    JMIR Formative Research.2024;[Epub]     CrossRef
  • Chitosan and Its Derivative-Based Nanoparticles in Gastrointestinal Cancers: Molecular Mechanisms of Action and Promising Anticancer Strategies
    Zahra Shokati Eshkiki, Fatemeh Mansouri, Amir Reza Karamzadeh, Abolfazl Namazi, Hafez Heydari, Javad Akhtari, Seidamir Pasha Tabaeian, Abolfazl Akbari, Hongda Liu
    Journal of Clinical Pharmacy and Therapeutics.2024; 2024: 1.     CrossRef
  • Cancer mortality predictions for 2024 in selected Asian countries and Australia with focus on stomach cancer
    Claudia Santucci, Silvia Mignozzi, Fabio Levi, Matteo Malvezzi, Paola Bertuccio, Anna Odone, M. Constanza Camargo, Carlo La Vecchia, Eva Negri
    European Journal of Cancer Prevention.2024;[Epub]     CrossRef
  • Qualitative Fecal Immunochemical Test as a Screening Test for Colorectal Cancer
    I Ketut Mariadi, Ni Nyoman Metriani Nesa, Gde Somayana, Kurniawan Kurniawan
    Research Journal of Pharmacy and Technology.2024; : 1050.     CrossRef
  • Oxidative Stress Assessment in Colorectal Cancer Patients
    Vyan A. Qadir, Kamaran K. Abdoulrahman
    ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY.2024; 12(1): 115.     CrossRef
  • Risk prediction of advanced colorectal neoplasia among diabetic patients: A derivation and validation study
    Martin CS Wong, Eman YM Leung, Harry HX Wang, Junjie Huang
    JGH Open.2024;[Epub]     CrossRef
  • Prediction of Lymph Node Metastasis in T1 Colorectal Cancer Using Artificial Intelligence with Hematoxylin and Eosin-Stained Whole-Slide-Images of Endoscopic and Surgical Resection Specimens
    Joo Hye Song, Eun Ran Kim, Yiyu Hong, Insuk Sohn, Soomin Ahn, Seok-Hyung Kim, Kee-Taek Jang
    Cancers.2024; 16(10): 1900.     CrossRef
  • Molecular epidemiology, antibiotic resistance profile and frequency of integron 1 and 2 in adherent-invasive Escherichia coli isolates of colorectal cancer patients
    Aida Heidari, Mohammad Hassan Emami, Fatemeh Maghool, Samane Mohammadzadeh, Parisa Kadkhodaei Elyaderani, Tahereh Safari, Alireza Fahim, Razie Kamali Dolatabadi
    Frontiers in Microbiology.2024;[Epub]     CrossRef
  • The association between neighborhood socioeconomic status and the risk of incidence and mortality of colorectal cancer: A systematic review and meta-analysis of 1,678,582 participants
    Faramarz Jalili, Mohammad Hajizadeh, Sanaz Mehrabani, Seyed Mojtaba Ghoreishy, Felicity MacIsaac
    Cancer Epidemiology.2024; 91: 102598.     CrossRef
  • Gut microbiota characteristics of colorectal cancer patients in Hubei, China, and differences with cohorts from other Chinese regions
    Jianguo Shi, Hexiao Shen, Hui Huang, Lifang Zhan, Wei Chen, Zhuohui Zhou, Yongling Lv, Kai Xiong, Zhiwei Jiang, Qiyi Chen, Lei Liu
    Frontiers in Microbiology.2024;[Epub]     CrossRef
  • The inhibitory effects of the novel Lactobacillus cocktail on colorectal cancer development through modulating BMP signaling pathway: In vitro and in vivo Study
    Amin Sepehr, Shadi Aghamohammad, Roya Ghanavati, Ali Karimi Bavandpour, Malihe Talebi, Mahdi Rohani, Mohammad Reza Pourshafie
    Heliyon.2024; : e36554.     CrossRef
  • Oncological characteristics, treatments and prognostic outcomes in MMR-deficient colorectal cancer
    Wen-Xuan Fan, Fei Su, Yan Zhang, Xiao-Ling Zhang, Yun-Yi Du, Yang-Jun Gao, Wei-Ling Li, Wen-Qing Hu, Jun Zhao
    Biomarker Research.2024;[Epub]     CrossRef
  • A higher dietary alpha-linolenic acid intake is associated with lower colorectal cancer risk based on MUC4 rs2246901 variant among Korean adults.
    Ha Thi Mien Nguyen, Madhawa Gunathilake, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
    Nutrition Research.2024;[Epub]     CrossRef
  • Biofilm mediated integrin activation and directing acceleration of colorectal cancer
    Vaijayanthi Saravanan, Vinoj Gopalakrishnan, Maria Infant Majula Shifani Mahendran, Rajan Vaithianathan, Sowmya Srinivasan, Vinoth Boopathy, SriKrishna Krishnamurthy
    APMIS.2024;[Epub]     CrossRef
  • Impact of a Health Promotion Program on Knowledge, Physical Health, Mental Health, and Social Health Behaviors in Individuals at Risk for Colorectal Cancer
    Surachet Fakkiew, Supat Teravecharoenchai, Panit Khemtong, Wanich Suksatan
    Societies.2024; 14(9): 182.     CrossRef
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    Belitung Nursing Journal.2023; 9(4): 331.     CrossRef
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    Journal of Pharmaceutical Sciences.2023; 112(1): 213.     CrossRef
  • Analysis of the gut microbiome using extracellular vesicles in the urine of patients with colorectal cancer
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    The Korean Journal of Internal Medicine.2023; 38(1): 27.     CrossRef
  • Exploration of Malaysian Stakeholders View on Barriers to and Facilitators of Colorectal Cancer Screening Among Older Population
    Sanpagavalli Doraimuthu, Maznah Dahlui, Victor Chee Wai Hoe, Tin Tin Su
    Asia Pacific Journal of Public Health.2023; 35(1): 27.     CrossRef
  • Effects of Soybean and Tempeh Water Extracts on Regulation of Intestinal Flora and Prevention of Colon Precancerous Lesions in Rats
    Nileema R. Divate, Katharina Ardanareswari, Yu-Ping Yu, Ya-Chen Chen, Jiunn-Wang Liao, Yun-Chin Chung
    Processes.2023; 11(1): 257.     CrossRef
  • Research Progress of Intestinal Microecology in the Pathogenesis of Colorectal Adenoma and Carcinogenesis
    Zhipeng Zhang, Nisma Lena Bahaji Azami, Ningning Liu, Mingyu Sun
    Technology in Cancer Research & Treatment.2023; 22: 153303382211359.     CrossRef
  • Phenolic Phytochemicals for Prevention and Treatment of Colorectal Cancer: A Critical Evaluation of In Vivo Studies
    Samhita De, Sourav Paul, Anirban Manna, Chirantan Majumder, Koustav Pal, Nicolette Casarcia, Arijit Mondal, Sabyasachi Banerjee, Vinod Kumar Nelson, Suvranil Ghosh, Joyita Hazra, Ashish Bhattacharjee, Subhash Chandra Mandal, Mahadeb Pal, Anupam Bishayee
    Cancers.2023; 15(3): 993.     CrossRef
  • Susceptibility to Colorectal Cancer Based on HSD17B4 rs721673 and rs721675 Polymorphisms and Alcohol Intake among Taiwan Biobank Participants: A Retrospective Case Control Study Using the Nationwide Claims Data
    Tzu-Chiao Lin, Min-Hua Chuang, Chia-Ni Hsiung, Pi-Kai Chang, Chien-An Sun, Tsan Yang, Yu-Ching Chou, Je-Ming Hu, Chih-Hsiung Hsu
    Journal of Personalized Medicine.2023; 13(4): 576.     CrossRef
  • Cinnamic acid derivatives as potential matrix metalloproteinase-9 inhibitors: molecular docking and dynamics simulations
    Mohammad Hossein Malekipour, Farzaneh Shirani, Shadi Moradi, Amir Taherkhani
    Genomics & Informatics.2023; 21(1): e9.     CrossRef
  • Insights on the Biomarker Potential of Exosomal Non-Coding RNAs in Colorectal Cancer: An In Silico Characterization of Related Exosomal lncRNA/circRNA–miRNA–Target Axis
    Maria Mezher, Samira Abdallah, Ohanes Ashekyan, Ayman Al Shoukari, Hayat Choubassy, Abdallah Kurdi, Sally Temraz, Rihab Nasr
    Cells.2023; 12(7): 1081.     CrossRef
  • Investigations on the cytotoxicity and antimicrobial activities of terezine E and 14-hydroxyterezine D
    M. Mojally, R. Abdou, W. Bokhari, S. Sab, M. Dawoud, A. Albohy
    Brazilian Journal of Medical and Biological Research.2023;[Epub]     CrossRef
  • Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation
    Akiko Hanyuda, Atsushi Goto, Ryoko Katagiri, Yuriko N. Koyanagi, Masahiro Nakatochi, Yoichi Sutoh, Shiori Nakano, Isao Oze, Hidemi Ito, Taiki Yamaji, Norie Sawada, Masao Iwagami, Aya Kadota, Teruhide Koyama, Sakurako Katsuura-Kamano, Hiroaki Ikezaki, Keit
    Scientific Reports.2023;[Epub]     CrossRef
  • Recent Progress and Perspective of an Evolving Carbon Family From 0D to 3D: Synthesis, Biomedical Applications, and Potential Challenges
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    ACS Applied Bio Materials.2023; 6(6): 2043.     CrossRef
  • Changing Colorectal Cancer Trends in Asians: Epidemiology and Risk Factors
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    Oncology Reviews.2023;[Epub]     CrossRef
  • Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with metastatic colorectal cancer
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    ESMO Open.2023; 8(3): 101558.     CrossRef
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    Current Pharmaceutical Biotechnology.2023; 24(8): 1018.     CrossRef
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    Cancer Epidemiology.2023; 86: 102415.     CrossRef
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  • Effects of ranitidine and nizatidine on the risk of gastrointestinal cancer
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    Frontiers in Oncology.2023;[Epub]     CrossRef
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    Current Cancer Drug Targets.2023; 23(10): 764.     CrossRef
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    Indian Journal of Pathology and Oncology.2023; 10(3): 224.     CrossRef
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    Journal of Evidence-Based Medicine.2023; 16(3): 332.     CrossRef
  • A novel proteomic-based model for predicting colorectal cancer with Schistosoma japonicum co‐infection by integrated bioinformatics analysis and machine learning
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    BMC Medical Genomics.2023;[Epub]     CrossRef
  • Implications of single-cell immune landscape of tumor microenvironment for the colorectal cancer diagnostics and therapy
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    BMC Nutrition.2023;[Epub]     CrossRef
  • ABO and Rhesus blood group markers as predictors in colorectal cancer: A prospective observational study
    Gowhar Rashid, Gulzar A. Bhat, Tahseen Bilal Rather, Kulsum Akhtar, Ishrat Parveiz, Syed Nisar Ahmad, Malik Tariq Rasool, Farooq Ahmad Jan, Mohanad Diab, Wael Hafez, Syed Mudassar
    Medicine.2023; 102(47): e36256.     CrossRef
  • Impact of alcohol consumption on risk of colorectal cancer in Eastern Mediterranean Regional Office (EMRO) countries: a systematic review and meta-analysis
    Mohammad-Hossein Keivanlou, Ehsan Amini-Salehi, Farahnaz Joukar, Naeim Norouzi, Negin Letafatkar, Arman Habibi, Fariborz Mansour-Ghanaei, Maryam Sadat Aleali, Mohammad Taghi Ashoobi, Soheil Hassanipour
    Journal of Public Health.2023;[Epub]     CrossRef
  • Rosemary as a Potential Source of Natural Antioxidants and Anticancer Agents: A Molecular Docking Study
    Haytham Bouammali, Linda Zraibi, Imane Ziani, Mohammed Merzouki, Lamiae Bourassi, Elmehdi Fraj, Allal Challioui, Khalil Azzaoui, Rachid Sabbahi, Belkheir Hammouti, Shehdeh Jodeh, Maryam Hassiba, Rachid Touzani
    Plants.2023; 13(1): 89.     CrossRef
  • EBP50 Depletion and Nuclear β-Catenin Accumulation Engender Aggressive Behavior of Colorectal Carcinoma through Induction of Tumor Budding
    Takashi Itou, Yu Ishibashi, Yasuko Oguri, Miki Hashimura, Ako Yokoi, Yohei Harada, Naomi Fukagawa, Misato Hayashi, Mototsugu Ono, Chika Kusano, Makoto Saegusa
    Cancers.2023; 16(1): 183.     CrossRef
  • Raptinal ameliorates 1,2-dimethylhydrazine-induced colon cancer through p53/Bcl2/Bax/caspase-3-mediated apoptotic events in vitro and in vivo
    Yongting Lan, Yang Yang, Abhijit Das, Barshana Bhattacharya, Souvik Roy
    Indian Journal of Pharmacology.2023; 55(2): 97.     CrossRef
  • Chemopreventive effects of anthocyanins on colorectal and breast cancer: A review
    David Bars-Cortina, Ali Sakhawat, Carme Piñol-Felis, María-Jose Motilva
    Seminars in Cancer Biology.2022; 81: 241.     CrossRef
  • A 10-year registry-based incidence, mortality, and survival analysis of colorectal cancer in Northern Malaysia
    Ibtisam Ismail, HuanKeat Chan, SoelarShahrul Aiman, AbuHassan Muhammad Radzi
    Journal of Cancer Research and Therapeutics.2022; 18(4): 931.     CrossRef
  • Risk of developing metachronous colorectal neoplasia after the resection of proximal versus distal adenomas
    Yoon Suk Jung, Nam Hee Kim, Youngwoo Kim, Dong Il Park
    Digestive and Liver Disease.2022; 54(4): 537.     CrossRef
  • Positive fecal immunochemical test results are associated with non-colorectal cancer mortality
    Yoon Suk Jung, Jinhee Lee, Chang Mo Moon
    The Korean Journal of Internal Medicine.2022; 37(2): 313.     CrossRef
  • Sessile serrated lesions in patients with adenoma on index colonoscopy do not increase metachronous advanced adenoma risk
    Seung Wook Hong, Jeongseok Kim, Ji Young Lee, Jong‐Soo Lee, Hye‐Sook Chang, Hye Won Park, Gwang‐Un Kim, Jiyoung Yoon, Byong Duk Ye, Jeong‐Sik Byeon, Seung‐Jae Myung, Suk‐Kyun Yang, Jaewon Choe, Dong‐Hoon Yang
    Digestive Endoscopy.2022; 34(4): 850.     CrossRef
  • Impact of antiplatelet agents and anticoagulants on the performance of fecal immunochemical tests: a systematic review and meta-analysis
    Yoon Suk Jung, Eui Im, Chan Hyuk Park
    Surgical Endoscopy.2022; 36(6): 4299.     CrossRef
  • Efficacy and safety of split-dose bowel preparation with 1 L polyethylene glycol and ascorbate compared with 2 L polyethylene glycol and ascorbate in a Korean population: a phase IV, multicenter, randomized, endoscopist-blinded study
    Sung Noh Hong, Chang Kyun Lee, Jong Pil Im, Chang Hwan Choi, Jeong-Sik Byeon, Young-Seok Cho, Sung-Ae Jung, Tae Il Kim, Yoon Tae Jeen
    Gastrointestinal Endoscopy.2022; 95(3): 500.     CrossRef
  • The role of anaerobic bacteria in the development and prevention of colorectal cancer: A review study
    Mehrdad Mohammadi, Hamed Mirzaei, Mitra Motallebi
    Anaerobe.2022; 73: 102501.     CrossRef
  • Prevalence and associated risk of advanced colorectal neoplasia in adults with sarcopenia
    Min Cheol Kim, Kyeong Ok Kim, Min Kyu Kang
    The Korean Journal of Internal Medicine.2022; 37(2): 294.     CrossRef
  • Factors associated with positive predictive value of preliminary screening in a two-step screening strategy for colorectal neoplasms in China
    Ji-Bin Li, Zhi-Yu Qiu, Yu-Xiang Deng, Yin Li, Zhuo-Chen Lin, Yan-Ping Wu, Fan Weng, Huan Tian, Qing-Jian Ou, Cheng-Hua Gong, Zhi-Zhong Pan, De-Sen Wan, Jian-Hong Peng, Yu-Jing Fang
    Discover Oncology.2022;[Epub]     CrossRef
  • Amelioration of DMH-induced colon cancer by eupafolin through the reprogramming of apoptosis-associated p53/Bcl2/Bax signaling in rats
    Congcong Wang, Xiao Qiao, Jingwen Wang, Jia Yang, Chen Yang, Yi Qiao, Yue Guan, Aidong Wen, Liuqin Jiang
    European Journal of Inflammation.2022; 20: 205873922110697.     CrossRef
  • Colorectal cancer patients advocating screening to their siblings: a randomized behavioral intervention
    Lina Choe, Jerrald Lau, Si-Ying Fong, Emily Chew, Wen-Min Chow, Yan Pang, Tian-Zhi Lim, Choon-Seng Chong, Min-Hoe Chew, Fung-Joon Foo, Frederick Hong-Xiang Koh, Mee-Lian Wong, Gerald Choon-Huat Koh, Ker-Kan Tan
    Gastrointestinal Endoscopy.2022; 95(3): 519.     CrossRef
  • Immune profile by multiplexed immunohistochemistry associated with recurrence after chemoradiation in rectal cancer
    Seung Wook Hong, Seohyun Lee, Yun Jae Kim, Soyeon Ahn, In Ja Park, Seung‐Mo Hong, Sung Wook Hwang, Sang Hyoung Park, Dong‐Hoon Yang, Byong Duk Ye, Jeong‐Sik Byeon, Suk‐Kyun Yang, Jaeil Kim, Sang‐Yeob Kim, Seung‐Jae Myung
    Journal of Gastroenterology and Hepatology.2022; 37(3): 542.     CrossRef
  • Screening and Evaluation of Probiotics for Reducing Intestinal Inflammation
    雅君 陈
    Hans Journal of Food and Nutrition Science.2022; 11(01): 44.     CrossRef
  • Factors Associated With Colorectal Cancer Screening Among First-Degree Relatives of Patients With Colorectal Cancer in China
    Qianqian Du, Jingyu Chen, Ya Meng, Ni Gong, Xiaodan Wu, Qiyuan Lyu, Yiheng Zhang, Xiaoyu Wu, Meifen Zhang
    Cancer Nursing.2022; 45(2): E447.     CrossRef
  • Detection and isolation of typical gut indigenous bacteria in mice fed corn starch, bread flour or whole wheat flour
    Natsumi Takei, Takashi Kuda, Natsumi Handa, Hajime Takahashi, Bon Kimura
    Food Bioengineering.2022; 1(1): 91.     CrossRef
  • Locations and histopathology of colorectal polyps in Turkey: experiences of two centers
    Zeynep S. BAHCE, Serdar GUMUS, Ebral YIGIT
    Chirurgia.2022;[Epub]     CrossRef
  • Risk of Metachronous Colorectal Advanced Neoplasia and Cancer in Patients With 3–4 Nonadvanced Adenomas at Index Colonoscopy: A Systematic Review and Meta-Analysis
    Suyeon Park, Seong Ran Jeon, Hyun Gun Kim, Yunho Jung, Min-Seob Kwak, Su Young Kim, Jong Wook Kim, Seung-Joo Nam, Eun Hye Oh, Seon-Young Park, Soo-Kyung Park, Jeong-Sik Byeon, Sun-Jin Boo, Dong Hoon Baek, Soon Man Yoon, Jaeyoung Chun, Jooyoung Lee, Miyoun
    American Journal of Gastroenterology.2022; 117(4): 588.     CrossRef
  • Can Computed Tomography Colonography Replace Optical Colonoscopy in Detecting Colorectal Lesions?: State of the Art
    Alessia Chini, Michele Manigrasso, Grazia Cantore, Rosa Maione, Marco Milone, Francesco Maione, Giovanni Domenico De Palma
    Clinical Endoscopy.2022; 55(2): 183.     CrossRef
  • Meta-Analysis of the Association between Dietary Inflammatory Index (DII) and Colorectal Cancer
    Sharifah Saffinas Syed Soffian, Azmawati Mohammed Nawi, Rozita Hod, Mohd Hasni Ja’afar, Zaleha Md Isa, Huan-Keat Chan, Muhammad Radzi Abu Hassan
    Nutrients.2022; 14(8): 1555.     CrossRef
  • Report of 13-year survival of patients with colon and rectal cancers; lessons from Shiraz colorectal cancer surgery registry system of a level three medical center
    Ali Reza Safarpour, Alimohammad Bananzadeh, Ahmad Izadpanah, Leila Ghahramani, Seyed Mohammad Kazem Tadayon, Faranak Bahrami, Seyed Vahid Hosseini
    BMC Surgery.2022;[Epub]     CrossRef
  • Effects of Jianpi Lishi Jiedu granules on colorectal adenoma patients after endoscopic treatment: study protocol for a randomized, double-blinded, placebo-controlled clinical trial
    Hao Wu, Yuzhen Huang, Lu Yang, Kunhan Su, Shuo Tian, Xin Chen, Siyu Li, Wanli Liu
    Trials.2022;[Epub]     CrossRef
  • Anticancer Properties of Curcumin Against Colorectal Cancer: A Review
    Oluwafemi Adeleke Ojo, Temiloluwa Rhoda Adeyemo, Damilare Rotimi, Gaber El-Saber Batiha, Gomaa Mostafa-Hedeab, Matthew Eboseremen Iyobhebhe, Tobiloba Christiana Elebiyo, Bukola Atunwa, Adebola Busola Ojo, Clara Mariana Goncalves Lima, Carlos Adam Conte-Ju
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Recent advances in the biosynthesis, structure–activity relationships, formulations, pharmacology, and clinical trials of fisetin
    Ruting Zhong, Mohamed A. Farag, Meiwan Chen, Chengwei He, Jianbo Xiao
    eFood.2022;[Epub]     CrossRef
  • The Influence of Face Shields on the Quality of Colonoscopy in the Era of the COVID-19 Pandemic
    Jin Wook Lee, Hyo Jeong Lee, Dae Sung Kim, Jiyoung Yoon, Seung Wook Hong, Ha Won Hwang, Jong-Soo Lee, Gwang-Un Kim, Sinwon Lee, Jaewon Choe, Jin Hwa Park, Dong-Hoon Yang, Jeong-Sik Byeon
    Gut and Liver.2022; 16(3): 404.     CrossRef
  • rs401502 and rs11575934 Polymorphisms of the IL-12 Receptor Beta 1 Gene are Protective Against Colorectal Carcinogenesis
    Refka Jelassi, Sabrine Dhouioui, Hamza Ben Salah, Nasreddine Saidi, Nabiha Mzoughi, Radhia Ammi, Aida Bouratbine, Karim Aoun, Ines Zidi, Hanen Chelbi
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • Quality indicators in colonoscopy: the chasm between ideal and reality
    Su Bee Park, Jae Myung Cha
    Clinical Endoscopy.2022; 55(3): 332.     CrossRef
  • Tumor Detection on Microarray Data Using Grey Wolf Optimization with Gain Information
    K. Dhana Sree Devi, P. Karthikeyan, Usha Moorthy, K. Deeba, V. Maheshwari, Shaikh Muhammad Allayear, Shimin Wang
    Mathematical Problems in Engineering.2022; 2022: 1.     CrossRef
  • A Systematic Review and Meta-analysis on the Occurrence of Biomarker Mutation in Colorectal Cancer among the Asian Population
    Hafeez Afolabi, Salzihan Md Salleh, Zaidi Zakaria, Ch’ng Ewe Seng, Siti Norasikin Binti Mohd Nafil, Ahmad Aizat Bin Abdul Aziz, Yusuf Wada, Ahmad Irekeola, Syed Sameer Aga
    BioMed Research International.2022; 2022: 1.     CrossRef
  • Title: Involvement of unsaturated fatty acid biosynthesis in CRC progression based on in vitro and in silico studies
    Khatere Mokhtari, Mohammad Mahdevar, Maral Hajipour, Maryam Esmaeili, Maryam Peymani, Sepideh Mirzaei, Mohammad Hossein Nasr-Esfahani, Mehrdad Hashemi, Kiavash Hushmandi, Kamran Ghaedi
    Biomedicine & Pharmacotherapy.2022; 153: 113338.     CrossRef
  • Anti-inflammatory and Antioxidant Effect of Lycoperoside H against the 1,2-Dimethyl Hydrazine (DMH) Induced Colorectal Cancer in Rats
    Yongjian Liu, Xin Qi
    Journal of Oleo Science.2022; 71(7): 1021.     CrossRef
  • Utility of artificial intelligence with deep learning of hematoxylin and eosin-stained whole slide images to predict lymph node metastasis in T1 colorectal cancer using endoscopically resected specimens; prediction of lymph node metastasis in T1 colorecta
    Joo Hye Song, Yiyu Hong, Eun Ran Kim, Seok-Hyung Kim, Insuk Sohn
    Journal of Gastroenterology.2022; 57(9): 654.     CrossRef
  • Plant-derived bioactive compounds in colon cancer treatment: An updated review
    Akanksha Esmeeta, Subhamay Adhikary, V. Dharshnaa, P. Swarnamughi, Z. Ummul Maqsummiya, Antara Banerjee, Surajit Pathak, Asim K. Duttaroy
    Biomedicine & Pharmacotherapy.2022; 153: 113384.     CrossRef
  • Harmol alleviates dimethylhydrazine induced colon cancer by downregulating Bcl2/IL-6/TNF-α expression in association with p53 mediated apoptosis
    Ni Guo, Jie Gao
    European Journal of Inflammation.2022; 20: 1721727X2211100.     CrossRef
  • Developing and validating polygenic risk scores for colorectal cancer risk prediction in East Asians
    Jie Ping, Yaohua Yang, Wanqing Wen, Sun‐Seog Kweon, Koichi Matsuda, Wei‐Hua Jia, Aesun Shin, Yu‐Tang Gao, Keitaro Matsuo, Jeongseon Kim, Dong‐Hyun Kim, Sun Ha Jee, Qiuyin Cai, Zhishan Chen, Ran Tao, Min‐Ho Shin, Chizu Tanikawa, Zhi‐Zhong Pan, Jae Hwan Oh,
    International Journal of Cancer.2022; 151(10): 1726.     CrossRef
  • The emerging era of personalized medicine in advanced colorectal cancer
    Claudia W K Wu, Madeleine Reid, Simon Leedham, Rashid N Lui
    Journal of Gastroenterology and Hepatology.2022; 37(8): 1411.     CrossRef
  • Crosstalk between mucosal microbiota, host gene expression, and sociomedical factors in the progression of colorectal cancer
    Namjoo Kim, Jeong-An Gim, Beom Jae Lee, Byung il Choi, Hee Sook Yoon, Seung Han Kim, Moon Kyung Joo, Jong-Jae Park, Chungyeul Kim
    Scientific Reports.2022;[Epub]     CrossRef
  • Long-Time Trend of Colorectal Cancer Mortality Attributable to High Processed Meat Intake in China and a Bayesian Projection from 2020 to 2030: A Model-Based Study
    Fangyao Chen, Shiyu Chen, Yaqi Luo, Aima Si, Yuhui Yang, Yemian Li, Weiwei Hu, Yuxiang Zhang
    International Journal of Environmental Research and Public Health.2022; 19(17): 10603.     CrossRef
  • Current Advances in Chitosan Nanoparticles Based Oral Drug Delivery for Colorectal Cancer Treatment
    Hazem Choukaife, Salma Seyam, Batoul Alallam, Abd Almonem Doolaanea, Mulham Alfatama
    International Journal of Nanomedicine.2022; Volume 17: 3933.     CrossRef
  • Analysing 11 years of incidence trends, clinicopathological characteristics, and forecasts of colorectal cancer in young and old patients: a retrospective cross-sectional study in an Indonesian national referral hospital
    Nur Rahadiani, Muhammad Habiburrahman, Murdani Abdullah, Wifanto Saditya Jeo, Marini Stephanie, Diah Rini Handjari, Ening Krisnuhoni
    BMJ Open.2022; 12(9): e060839.     CrossRef
  • Colorectal cancer in patients with SARS-CoV-2: a systematic review and meta-analysis
    Saad Alhumaid, Abbas Al Mutair, Jawad S. Busubaih, Nourah Al Dossary, Murtadha Alsuliman, Sarah A. Baltyour, Ibrahim Alissa, Hassan I. Al Hassar, Noor A. Al Aithan, Hani A. Albassri, Suliman A. AlOmran, Raed M. ALGhazal, Ahmed Busbaih, Nasser A. Alsalem,
    Infectious Agents and Cancer.2022;[Epub]     CrossRef
  • Association between A Family History of Colorectal Cancer and the Risk of Colorectal Cancer: A Nationwide Population-Based Study
    Yoon Suk Jung, Huiyeon Song, Mai Thi Xuan Tran, Boyoung Park, Chang Mo Moon
    Journal of Personalized Medicine.2022; 12(10): 1566.     CrossRef
  • ERCC1 Overexpression Increases Radioresistance in Colorectal Cancer Cells
    Yi-Jung Huang, Ming-Yii Huang, Tian-Lu Cheng, Shih-Hsun Kuo, Chien-Chih Ke, Yi-Ting Chen, Yuan-Chin Hsieh, Jaw-Yuan Wang, Chiu-Min Cheng, Chih-Hung Chuang
    Cancers.2022; 14(19): 4798.     CrossRef
  • Dietary Nonstarch Polysaccharide Intake and Risk of Colorectal Cancer: Findings from the Singapore Chinese Health Study
    Yi-Chuan Yu, Pedram Paragomi, Aizhen Jin, Renwei Wang, Robert E. Schoen, Woon-Puay Koh, Jian-Min Yuan, Hung N. Luu
    Cancer Research Communications.2022; 2(10): 1304.     CrossRef
  • Expression of Vascular Endothelial Growth Factor (VEGF) in Colorectal Adenoma and Carcinoma in a Tertiary Care Center
    Subalakshmi Balasubramanian, Nagarajan Priyathersini, Thanka Johnson
    Cureus.2022;[Epub]     CrossRef
  • Clinicopathological characteristics of high microsatellite instability/mismatch repair-deficient colorectal cancer: A narrative review
    Wei-Jian Mei, Mi Mi, Jing Qian, Nan Xiao, Ying Yuan, Pei-Rong Ding
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Diagnosis by Volatile Organic Compounds in Exhaled Breath from Patients with Gastric and Colorectal Cancers
    Jinwook Chung, Salima Akter, Sunhee Han, Yoonhwa Shin, Tae Choi, Insug Kang, Sung Kim
    International Journal of Molecular Sciences.2022; 24(1): 129.     CrossRef
  • Association between Diet-related Behaviour and Risk of Colorectal Cancer: A Scoping Review
    Nur Mahirah Amani Binti Mohammad, Mohd Razif Shahril, Suzana Shahar, Michael Fenech, Razinah Sharif
    Journal of Cancer Prevention.2022; 27(4): 208.     CrossRef
  • Inhibition of Cell Proliferation and Induction of Cell Cycle Arrest in Colon Cancer Cells by Lyophilized Mango (Mangifera indicaL.) Pulp Extract
    Gustavo Argenor Lozano-Casabianca, Sandra Sulay Arango-Varela, Johanny Aguillón-Osma, María Alejandra Llano-Ramírez, María Elena Maldonado-Celis
    Preventive Nutrition and Food Science.2022; 27(4): 436.     CrossRef
  • Hereditary, environmental, and dietary risk factors of colorectal cancer: a case-control study in the Algerian East
    Samira Negrichi, Salima Taleb
    Environmental Science and Pollution Research.2021; 28(10): 12372.     CrossRef
  • Risk of Colorectal Cancer in Patients With Attention-Deficit Hyperactivity Disorder: A Nationwide, Population-Based Cohort Study
    Je-Ming Hu, Chia-Cheng Lee, Tzu-Chiao Lin, Chi-Hsiang Chung, Chao-Yang Chen, Pi-Kai Chang, Cheng-Wen Hsiao, Chien-An Sun, Nian-Sheng Tzeng, Wu-Chien Chien
    Frontiers in Psychiatry.2021;[Epub]     CrossRef
  • Incidence and Risk Factors of Colorectal Cancer in the Iranian Population: a Systematic Review
    Hossein Mozafar Saadati, Batool Okhovat, Farzad Khodamoradi
    Journal of Gastrointestinal Cancer.2021; 52(2): 414.     CrossRef
  • Increasing changes in visceral adiposity is associated with higher risk for colorectal adenoma: Multilevel analysis in a prospective cohort
    Jung Min Moon, Jong Pil Im, Donghee Kim, Yoo Min Han, Hosim Soh, Ji Hyun Song, Sun Young Yang, Young Sun Kim, Jeong Yoon Yim, Seon Hee Lim, Joo Sung Kim
    Journal of Gastroenterology and Hepatology.2021; 36(7): 1836.     CrossRef
  • Dietary Intake as Determinant Nongenetic Factors to Colorectal Cancer Incidence and Staging Progression: A Study in South Sulawesi Population, Indonesia
    Ika Nurlaila, Alam A. Hidayat, Arif Budiarto, Bharuno Mahesworo, Kartika Purwandari, Bens Pardamean
    Nutrition and Cancer.2021; 73(11-12): 2523.     CrossRef
  • Comparison of Risk of Metachronous Advanced Colorectal Neoplasia in Patients with Sporadic Adenomas Aged < 50 Versus ≥ 50 years: A Systematic Review and Meta-Analysis
    Yoon Suk Jung, Jung Ho Park, Chan Hyuk Park
    Journal of Personalized Medicine.2021; 11(2): 120.     CrossRef
  • Survival of colorectal cancer patients in Brunei Darussalam: comparison between 2002–09 and 2010–17
    Shirley H. F. Lee, Hanif Abdul Rahman, Nadiah Abidin, Sok King Ong, Elvynna Leong, Lin Naing
    BMC Cancer.2021;[Epub]     CrossRef
  • Schistosoma japonicum Associated With Colorectal Cancer
    Anas Almoghrabi, Obaie Mzaik, Bashar Attar
    ACG Case Reports Journal.2021; 8(5): e00572.     CrossRef
  • Use of Antiplatelet Agents Decreases the Positive Predictive Value of Fecal Immunochemical Tests for Colorectal Cancer but Does Not Affect Their Sensitivity
    Yoonsuk Jung, Eui Im, Jinhee Lee, Hyeah Lee, Changmo Moon
    Journal of Personalized Medicine.2021; 11(6): 497.     CrossRef
  • Risk of colorectal cancer in patients with positive results of fecal immunochemical test performed within 5 years since the last colonoscopy
    Yoon Suk Jung, Jinhee Lee, Chang Mo Moon
    The Korean Journal of Internal Medicine.2021; 36(5): 1083.     CrossRef
  • Strategies for colorectal cancer screening and post-polypectomy surveillance for young adults under age 50
    Yoon Suk Jung
    Precision and Future Medicine.2021; 5(2): 69.     CrossRef
  • CTSE Overexpression Is an Adverse Prognostic Factor for Survival among Rectal Cancer Patients Receiving CCRT
    Chia-Lin Chou, Tzu-Ju Chen, Yu-Feng Tian, Ti-Chun Chan, Cheng-Fa Yeh, Wan-Shan Li, Hsin-Hwa Tsai, Chien-Feng Li, Hong-Yue Lai
    Life.2021; 11(7): 646.     CrossRef
  • Risk-stratified colorectal cancer screening for optimal use of colonoscopy resources
    Dong-Hoon Yang
    The Korean Journal of Internal Medicine.2021; 36(4): 839.     CrossRef
  • Orally Administrable Therapeutic Nanoparticles for the Treatment of Colorectal Cancer
    Kangkang Ying, Bingjun Bai, Xing Gao, Yuzi Xu, Hangxiang Wang, Binbin Xie
    Frontiers in Bioengineering and Biotechnology.2021;[Epub]     CrossRef
  • RNA-sequencing identification and validation of genes differentially expressed in high-risk adenoma, advanced colorectal cancer, and normal controls
    Namjoo Kim, Jeong-An Gim, Beom Jae Lee, Byung il Choi, Seung Bin Park, Hee Sook Yoon, Sang Hee Kang, Seung Han Kim, Moon Kyung Joo, Jong-Jae Park, Chungyeul Kim, Han-Kyeom Kim
    Functional & Integrative Genomics.2021; 21(3-4): 513.     CrossRef
  • Metabolic Evidence Rather Than Amounts of Red or Processed Meat as a Risk on Korean Colorectal Cancer
    Eunbee Kim, Joon Seok Lee, Eunjae Kim, Myung-Ah Lee, Alfred N. Fonteh, Michael Kwong, Yoon Hee Cho, Un Jae Lee, Mihi Yang
    Metabolites.2021; 11(7): 462.     CrossRef
  • Participation Rate, Risk Factors, and Incidence of Colorectal Cancer in the Screening Program Among the Population Covered by the Health Centers in Arak, Iran
    Pegah Mohaghegh, Farzane Ahmadi, Mahjabin Shiravandi, Javad Nazari
    International Journal of Cancer Management.2021;[Epub]     CrossRef
  • Detection of Colon Polyps in India—A Large Retrospective Cohort Study (DoCPIr)
    Nitin Jagtap, Aniruddha Pratap Singh, Pradev Inavolu, Manu Tandan, Shubhankar Godbole, Pranav Ambardekar, Anuradha Sekaran, Sundeep Lakhtakia, Mohan Ramchandani, Rakesh Kalapala, Rajesh Gupta, P. Manohar Reddy, Zaheer Nabi, Radhika Chavan, G. Venkat Rao,
    Journal of Digestive Endoscopy.2021; 12(02): 063.     CrossRef
  • Exosomal Components and Modulators in Colorectal Cancer: Novel Diagnosis and Prognosis Biomarkers
    Yu-Chan Chang, Ming-Hsien Chan, Chien-Hsiu Li, Chih-Yeu Fang, Michael Hsiao, Chi-Long Chen
    Biomedicines.2021; 9(8): 931.     CrossRef
  • Extricating the Association Between the Prognostic Factors of Colorectal Cancer
    Younis Mohd, Balamuralikrishnan Balasubramanian, Arun Meyyazhagan, Haripriya Kuchi Bhotla, Suresh Kumar Shanmugam, Mithun Kumar Ramesh Kumar, Manikantan Pappusamy, Karthick Kumar Alagamuthu, Sasikala Keshavarao, Vijaya Anand Arumugam
    Journal of Gastrointestinal Cancer.2021; 52(3): 1022.     CrossRef
  • Association between the serum concentrations and mutational status of IL‑8, IL‑27 and VEGF and the expression levels of the hERG potassium channel gene in patients with colorectal cancer
    Marewan Abid, Fikry Qadir, Abbas Salihi
    Oncology Letters.2021;[Epub]     CrossRef
  • Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis treatment and follow-up of patients with localised colon cancer
    T. Yoshino, G. Argilés, E. Oki, E. Martinelli, H. Taniguchi, D. Arnold, S. Mishima, Y. Li, B.K. Smruti, J.B. Ahn, I. Faud, C.E. Chee, K.-H. Yeh, P.-C. Lin, C. Chua, H.H. Hasbullah, M.A. Lee, A. Sharma, Y. Sun, G. Curigliano, H. Bando, F. Lordick, T. Yaman
    Annals of Oncology.2021; 32(12): 1496.     CrossRef
  • Recent Updates on Mechanisms of Resistance to 5-Fluorouracil and Reversal Strategies in Colon Cancer Treatment
    Shamin Azwar, Heng Fong Seow, Maha Abdullah, Mohd Faisal Jabar, Norhafizah Mohtarrudin
    Biology.2021; 10(9): 854.     CrossRef
  • Association of four genetic variants with colorectal cancer in Kazakhstan population
    Yevgeniya Kolesnikova, Dmitriy Babenko, Irina Kadyrova, Svetlana Kolesnichenko, Lyudmila Akhmaltdinova, Ilya Korshukov, Naylya Kabildina, Valentina Sirota, Vera Zhumaliyeva, Dana Taizhanova, Dmitriy Vazenmiller, Anar Turmukhambetova
    Oncotarget.2021; 12(21): 2215.     CrossRef
  • Exosomal circRNAs: new players in colorectal cancer
    Faezeh Vakhshiteh, Shokoufeh Hassani, Navid Momenifar, Fatemeh Pakdaman
    Cancer Cell International.2021;[Epub]     CrossRef
  • Screening and prevention of colorectal cancer
    Priyanka Kanth, John M Inadomi
    BMJ.2021; : n1855.     CrossRef
  • Can Real-time Computer-Aided Detection Systems Diminish the Risk of Postcolonoscopy Colorectal Cancer?
    Mariusz Madalinski, Roger Prudham
    JMIR Medical Informatics.2021; 9(12): e25328.     CrossRef
  • Bioinformatic analysis reveals in common genes between colorectal cancer and recurrent colorectal malignancy
    Rasoul Nemati, Mehdi Valizadeh, Mehrdad Mohammadi, Atena Kamali
    Gene Reports.2021; 25: 101375.     CrossRef
  • Colorectal Cancer in Uganda: A 10-Year, Facility-Based, Retrospective Study
    Godfrey Wekha, Nelson Ssewante, Angelique Iradukunda, Micheal Jurua, Shadia Nalwoga, Sharon Lanyero, Ronald Olum, Felix Bongomin
    Cancer Management and Research.2021; Volume 13: 7697.     CrossRef
  • Area-Level Determinants in Colorectal Cancer Spatial Clustering Studies: A Systematic Review
    Sharifah Saffinas Syed Soffian, Azmawati Mohammed Nawi, Rozita Hod, Huan-Keat Chan, Muhammad Radzi Abu Hassan
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Original Articles
Inflammatory bowel diseases
Iranian Registry of Crohn’s and Colitis: study profile of first nation-wide inflammatory bowel disease registry in Middle East
Masoud M Malekzadeh, Alireza Sima, Sudabeh Alatab, Anahita Sadeghi, Nasser Ebrahimi Daryani, Payman Adibi, Iradj Maleki, Hassan Vossoughinia, Hafez Fakheri, Abbas Yazdanbod, Seyed Alireza Taghavi, Rahim Aghazadeh, Mohammad Hassan Somi, Kazem Zendedel, Homayoon Vahedi, Reza Malekzadeh
Intest Res 2019;17(3):330-339.   Published online April 24, 2019
DOI: https://doi.org/10.5217/ir.2018.00157
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background/Aims
A recent study revealed increasing incidence and prevalence of inflammatory bowel disease (IBD) in Iran. The Iranian Registry of Crohn’s and Colitis (IRCC) was designed recently to answer the needs. We reported the design, methods of data collection, and aims of IRCC in this paper.
Methods
IRCC is a multicenter prospective registry, which is established with collaboration of more than 100 gastroenterologists from different provinces of Iran. Minimum data set for IRCC was defined according to an international consensus on standard set of outcomes for IBD. A pilot feasibility study was performed on 553 IBD patients with a web-based questionnaire. The reliability of questionnaire evaluated by Cronbach’s α.
Results
All sections of questionnaire had Cronbach’s α of more than 0.6. In pilot study, 312 of participants (56.4%) were male and mean age was 38 years (standard deviation=12.8) and 378 patients (68.35%) had ulcerative colitis, 303 subjects (54,7%) had college education and 358 patients (64.74%) were of Fars ethnicity. We found that 68 (12.3%), 44 (7.9%), 13 (2.3%) of participants were smokers, hookah and opium users, respectively. History of appendectomy was reported in 58 of patients (10.48%). The most common medication was 5-aminosalicylate (94.39%).
Conclusions
To the best of our knowledge, IRCC is the first national IBD registry in the Middle East and could become a reliable infrastructure for national and international research on IBD. IRCC will improve the quality of care of IBD patients and provide national information for policy makers to better plan for controlling IBD in Iran.

Citations

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  • Genomic testing identifies monogenic causes in patients with very early-onset inflammatory bowel disease: a multicenter survey in an Iranian cohort
    Golnaz Eslamian, Mahnaz Jamee, Tooba Momen, Pejman Rohani, Sarehossadat Ebrahimi, Mehrnaz Mesdaghi, Soodeh Ghadimi, Mahboubeh Mansouri, Seyed Alireza Mahdaviani, Mahnaz Sadeghi-shabestari, Morteza Fallahpour, Bibi Shahin Shamsian, Narges Eslami, Samin Sha
    Clinical and Experimental Immunology.2024; 217(1): 1.     CrossRef
  • Sex and age differences in inflammatory bowel disease patients; a nationwide study based on Iranian Registry of Crohn’s and Colitis (IRCC)
    Shaghayegh Khanmohammadi, Ali Sheidaei, Sudabeh Alatab, Ozra Tabatabaei-Malazy, Homayoon Vahedi, Fariborz Mansour-Ghanaei, Hafez Fakheri, Farshad Sheikhesmaeili, Anahita Sadeghi, Ali Reza Sima, Amir Anushiravan, Abbas Yazdanbod, Seyed Hamid Moosavy, Iradj
    PLOS ONE.2024; 19(7): e0304792.     CrossRef
  • The cost of illness analysis of inflammatory bowel disease
    Majid Pakdin, Leila Zarei, Kamran Bagheri Lankarani, Sulmaz Ghahramani
    BMC Gastroenterology.2023;[Epub]     CrossRef
  • Iranian Consensus Guideline for Pharmacotherapy with Biologics and Small Molecules Drugs in Adults with Inflammatory Bowel Diseases
    Niloofar Khoshnam-Rad, Homayoon Vahedi, Anahita Sadeghi, Mansoor Rastegarpanah, Soha Namazi, Amir Anushiravani, Ali Reza Sima, Shabnam Shahrokh, Sudabeh Alatab, Reza Malekzadeh
    Middle East Journal of Digestive Diseases.2023; 15(2): 83.     CrossRef
  • Clinical Phenotype and Disease Course of Inflammatory Bowel Disease: A Comparison Between Sporadic and Familial Cases
    Bahar Saberzadeh-Ardestani, Amir Anushiravani, Fariborz Mansour-Ghanaei, Hafez Fakheri, Homayoon Vahedi, Farshad Sheikhesmaeili, Abbas Yazdanbod, Seyed Hamid Moosavy, Hasan Vosoghinia, Iradj Maleki, Siavosh Nasseri-Moghaddam, Bardia Khosravi, Masoud Malek
    Inflammatory Bowel Diseases.2022; 28(7): 1004.     CrossRef
  • Susceptibility of Patients with Inflammatory Bowel Disease to COVID-19 Compared with Their Households
    Amir Anushiravani, Bahar Saberzadeh-Ardestani, Homayoon Vahedi, Hafez Fakheri, Fariborz Mansour-Ghanaei, Iraj Maleki, Siavosh Nasseri-Moghaddam, Hasan Vosoghinia, Mohammad Reza Ghadir, Ahmad Hormati, Amir Kasaeian, Amir Reza Radmard, Bardia Khosravi, Maso
    Middle East Journal of Digestive Diseases.2022; 14(2): 182.     CrossRef
  • Risk Factors Affecting 90-day Readmission of Patients with Inflammatory Bowel Disease
    Sulmaz Ghahramani, Zahra Tamartash, Mohammad Sayari, Homayoun Vahedi, Fatemeh Karimian, Sadegh Heydari, Kamran Bagheri Lankarani
    Middle East Journal of Digestive Diseases.2022; 14(1): 34.     CrossRef
  • What Are the Different Phenotypes of Inflammatory Bowel Disease in Asia?
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    Gut and Liver.2022; 16(5): 676.     CrossRef
  • The clinical significance of biliary findings in magnetic resonance enterography of patients with inflammatory bowel disease
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    Polish Journal of Radiology.2022; 87: 613.     CrossRef
  • Colitis and Crohn’s Foundation (India): a first nationwide inflammatory bowel disease registry
    Ajit Sood, Kirandeep Kaur, Ramit Mahajan, Vandana Midha, Arshdeep Singh, Sarit Sharma, Amarender Singh Puri, Bhabhadev Goswami, Devendra Desai, C. Ganesh Pai, Kiran Peddi, Mathew Philip, Rakesh Kochhar, Sandeep Nijhawan, Shobna Bhatia, N. Sridhara Rao
    Intestinal Research.2021; 19(2): 206.     CrossRef
  • Enteroscopy in Crohn’s Disease: Are There Any Changes in Role or Outcomes Over Time? A KASID Multicenter Study
    Seong Ran Jeon, Jin-Oh Kim, Jeong-Sik Byeon, Dong-Hoon Yang, Bong Min Ko, Hyeon Jeong Goong, Hyun Joo Jang, Soo Jung Park, Eun Ran Kim, Sung Noh Hong, Jong Pil Im, Seong-Eun Kim, Ja Seol Koo, Chang Soo Eun, Dong Kyung Chang
    Gut and Liver.2021; 15(3): 375.     CrossRef
  • Short-term tolerability and effectiveness of methotrexate monotherapy in adult patients with Crohn’s disease: a retrospective study
    Hee Seung Hong, Kyuwon Kim, Kyunghwan Oh, Jae Yong Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park
    Therapeutic Advances in Gastroenterology.2021; 14: 175628482110430.     CrossRef
  • Treatment of inflammatory bowel diseases: focusing on 5-aminosalicylates and immunomodulators
    You Sun Kim
    Journal of the Korean Medical Association.2021; 64(9): 596.     CrossRef
  • Association of LRRK2 rs11564258 single nucleotide polymorphisms with type and extent of gastrointestinal mycobiome in ulcerative colitis: a case–control study
    Niusha Sharifinejad, Seyed Hamidreza Mozhgani, Mahmood Bakhtiyari, Elaheh Mahmoudi
    Gut Pathogens.2021;[Epub]     CrossRef
  • Anti-TNF containing regimens may be associated with increased risk of Clostridioides difficile infection in patients with underlying inflammatory bowel disease
    Fahimeh Sadat Gholam-Mostafaei, Abbas Yadegar, Hamid Asadzadeh Aghdaei, Masoumeh Azimirad, Nasser Ebrahimi Daryani, Mohammad Reza Zali
    Current Research in Translational Medicine.2020; 68(3): 125.     CrossRef
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Inflammatory bowel diseases
Ustekinumab is effective in biological refractory Crohn’s disease patients–regardless of approval study selection criteria
Sadik Saman, Martin Goetz, Judith Wendler, Nisar P. Malek, Jan Wehkamp, Thomas Klag
Intest Res 2019;17(3):340-348.   Published online May 31, 2019
DOI: https://doi.org/10.5217/ir.2019.00012
AbstractAbstract PDFPubReaderePub
Background/Aims
Ustekinumab is effective in active Crohn’s disease. In a retrospective study we assessed the clinical outcome in nonresponders to anti-tumor necrosis factor therapy, and/or conventional therapy and/or the α4β7-integrin inhibitor vedolizumab. As approval study populations do not always reflect the average “real world” patient cohort, we assessed weather patients who would not have qualified for approval studies show similar outcomes.
Methods
Forty-one patients with mild to severe active Crohn’s disease were treated with ustekinumab (intravenous 6 mg per kg/body weight) followed by subcutaneous ustekinumab (90 mg) at week 8. Depending on the clinical response maintenance therapy was chosen every 8 or 12 weeks. Clinical response was defined by Crohn’s Disease Activity Index (CDAI) decline, decline of stool frequency or clinical improvement. Inclusion criteria for approval studies were assessed.
Results
The 58.5% (24/41) showed clinical response to ustekinumab. The 58.3% of this group (14/24) achieved clinical remission. Clinical response correlated significantly with drop of stool frequency and improvement of CDAI score. The 39 out of 41 patients had no side effects and we observed no serious infections. About a third of our patients would not have met ustekinumab approval study criteria. However, patients who did not meet study criteria showed clinical improvement numerically in the same range compared to patients who would have qualified for approval studies.
Conclusions
Ustekinumab is effective, safe and well tolerated in a highly therapy refractory patient cohort. Even though a reasonable number of patients did not meet ustekinumab approval study criteria, approval study results seem to be representative to the overall patient cohort.

Citations

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  • Comparative effectiveness and safety of ustekinumab at different intervals of maintenance phase in inflammatory bowel disease: a systematic review and meta-analysis
    Yaqing Bai, Yinghao Sun, Qi He, Xiaoyin Bai, Hong Yang
    European Journal of Gastroenterology & Hepatology.2024; 36(4): 359.     CrossRef
  • Long-term real-world data of ustekinumab in Crohn’s disease: the Stockholm ustekinumab study
    Francesca Bello, Samer Muhsen, Haider Sabhan, Alexandra Borin, Fredrik Johansson, Charlotte Höög, Ole Forsberg, Christina Wennerström, Charlotte Söderman, Mikael Lördal, Sven Almer
    Therapeutic Advances in Gastroenterology.2024;[Epub]     CrossRef
  • Effectiveness and Safety of Ustekinumab in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
    Sailish Honap, Susanna Meade, Hajir Ibraheim, Peter M. Irving, Michael P. Jones, Mark A. Samaan
    Digestive Diseases and Sciences.2022; 67(3): 1018.     CrossRef
  • Systematic review with meta‐analysis: loss of response and requirement of ustekinumab dose escalation in inflammatory bowel diseases
    Hongsheng Yang, Bingyang Li, Qin Guo, Jian Tang, Bo Peng, Ni Ding, Miao Li, Qingfang Yang, Zicheng Huang, Na Diao, Xia Zhu, Jun Deng, Huili Guo, Pinjin Hu, Kang Chao, Xiang Gao
    Alimentary Pharmacology & Therapeutics.2022; 55(7): 764.     CrossRef
  • Clinically reversible ustekinumab-induced encephalopathy: case report and review of the literature
    Jordi Sarto, Berta Caballol, Joan Berenguer, Iban Aldecoa, Álvaro Carbayo, Daniel Santana, Ivan Archilla, Carles Gaig, Francesc Graus, Julián Panés, Albert Saiz
    Therapeutic Advances in Neurological Disorders.2022; 15: 175628642210796.     CrossRef
  • Safety and Efficacy of Ustekinumab in the Treatment of Crohn Disease: A Systematic Review and Meta-analysis
    Mohammed Assem Khorshid, Ahmed Cordie, Sherief Abd-Elsalam
    Journal of Coloproctology.2022; 42(02): 178.     CrossRef
  • Real-World Evidence of the Effectiveness and Safety of Ustekinumab for the Treatment of Crohn’s Disease: Systematic Review and Meta-Analysis of Observational Studies
    Cristina Rubín de Célix, María Chaparro, Javier P. Gisbert
    Journal of Clinical Medicine.2022; 11(14): 4202.     CrossRef
  • Management of inflammatory bowel disease beyond tumor necrosis factor inhibitors: novel biologics and small-molecule drugs
    Soo-Young Na, You Sun Kim
    The Korean Journal of Internal Medicine.2022; 37(5): 906.     CrossRef
  • Prospective observational study on Stelara (ustekinumab) assessing effectiveness in Crohn’s disease (PROSE): a 16-week follow-up
    Anders Forss, Mark Clements, Pär Myrelid, Hans Strid, Charlotte Söderman, Agnieszka Wagner, David Andersson, Fredrik Hjelm, Ola Olén, Jonas F. Ludvigsson, Jonas Halfvarson
    Scandinavian Journal of Gastroenterology.2021; 56(6): 680.     CrossRef
  • Efficacy and tolerability of infliximab retreatment in patients with inflammatory bowel disease: a systematic review and meta-analysis
    Seungwon Yang, Siyoung Yang, Young Kwon Jo, Seungyeon Kim, Min Jung Chang, Junjeong Choi, Jae Hee Cheon, Yun Mi Yu
    Therapeutic Advances in Chronic Disease.2021; 12: 204062232110419.     CrossRef
  • Treatment of inflammatory bowel diseases: focusing on biologic agents and new therapies
    Hyo Yeop Song, Geom Seog Seo
    Journal of the Korean Medical Association.2021; 64(9): 605.     CrossRef
  • Eficacia y seguridad de ustekinumab en la práctica clínica real. Estudio multicéntrico retrospectivo. Cohorte ARAINF
    Diego Casas Deza, Santiago García López, Miguel Lafuente Blasco, Raquel Vicente Lidón, Juan Nerín de la Puerta, Elena Peña Gonzalez, Yolanda Ber Nieto, Mara Charro Calvillo, María José Alcalá Escriche, Fernando Gomollón García, Maite Arroyo Villarino
    Gastroenterología y Hepatología.2020; 43(3): 126.     CrossRef
  • Effectiveness and safety of Ustekinumab for the treatment of Crohn’s disease in real-life experiences: a meta-analysis of observational studies
    Fabio Salvatore Macaluso, Marcello Maida, Marco Ventimiglia, Mario Cottone, Ambrogio Orlando
    Expert Opinion on Biological Therapy.2020; 20(2): 193.     CrossRef
  • Efficacy and safety of ustekinumab in real clinical practice. Retrospective multicentre study. ARAINF cohort
    Diego Casas Deza, Santiago García López, Miguel Lafuente Blasco, Raquel Vicente Lidón, Juan Nerín de la Puerta, Elena Peña Gonzalez, Yolanda Ber Nieto, Mara Charro Calvillo, María José Alcalá Escriche, Fernando Gomollón García, Maite Arroyo Villarino
    Gastroenterología y Hepatología (English Edition).2020; 43(3): 126.     CrossRef
  • Ustekinumab en enfermedad de Crohn: efectividad y seguridad en práctica clínica
    Cristina Saldaña Dueñas, María Rullán Iriarte, Alfonso Elosua González, Cristina Rodríguez Gutiérrez, Saioa Rubio Iturria, Óscar Nantes Castillejo
    Gastroenterología y Hepatología.2020; 43(9): 497.     CrossRef
  • Real‐world long‐term effectiveness of ustekinumab in Crohn's disease: results from the ENEIDA registry
    Marisa Iborra, Belén Beltrán, Agnes Fernández‐Clotet, Eva Iglesias‐Flores, Pablo Navarro, Montserrat Rivero, Ana Gutiérrez, Mónica Sierra‐Ausin, Francisco Mesonero, Rocío Ferreiro‐Iglesias, Joaquín Hinojosa, Xavier Calvet, Beatriz Sicilia, Carlos González
    Alimentary Pharmacology & Therapeutics.2020; 52(6): 1017.     CrossRef
  • Objectively assessed disease activity and drug persistence during ustekinumab treatment in a nationwide real-world Crohn’s disease cohort
    Clas-Göran af Björkesten, Tuire Ilus, Taru Hallinen, Erkki Soini, Anja Eberl, Kalle Hakala, Mikko Heikura, Airi Jussila, Ritva Koskela, Inka Koskinen, Veikko Moilanen, Christian Nielsen, Urpo Nieminen, Heikki Nuutinen, Markku Heikkinen, Ulla-Maija Suhonen
    European Journal of Gastroenterology & Hepatology.2020; 32(12): 1507.     CrossRef
  • Ustekinumab in Crohn's disease: Effectiveness and safety in clinical practice
    Cristina Saldaña Dueñas, María Rullán Iriarte, Alfonso Elosua González, Cristina Rodríguez Gutiérrez, Saioa Rubio Iturria, Óscar Nantes Castillejo
    Gastroenterología y Hepatología (English Edition).2020; 43(9): 497.     CrossRef
  • Editorial: real‐world short‐term effectiveness of ustekinumab in 305 patients with Crohn’s disease—results from the ENEIDA registry. Authors' reply
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    Alimentary Pharmacology & Therapeutics.2019; 50(5): 600.     CrossRef
  • 7,798 View
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Inflammatory bowel diseases
Adherence to Asacol once daily versus divided regimen for maintenance therapy in ulcerative colitis: a prospective, multicenter, randomized study
Soo-Kyung Park, Sang Hyun Park, Chang Soo Eun, Geom Seog Seo, Jong Pil Im, Tae Oh Kim, Dong-Il Park
Intest Res 2019;17(3):349-356.   Published online February 8, 2019
DOI: https://doi.org/10.5217/ir.2018.00064
AbstractAbstract PDFPubReaderePub
Background/Aims
A once-daily (OD) regimen of 5-aminosalicylic acid (5-ASA) was easier to comply with than a divided daily (DD) regimen, and that treatment efficacy for ulcerative colitis (UC) was not affected by the dosing regimen. This study evaluated treatment adherence of OD and DD dosing in the Korean UC patients.
Methods
This study was a prospective, multicenter, randomized trial. UC patients were enrolled who have been in remission for more than 3 months. Patients were randomly assigned to the OD or DD group in a 1:1 ratio. The primary endpoint was adherence rate measured by tablet counts and self-reported adherence rate at 3, 6, 9, and 12 months. The relapse rate was measured at 1 year.
Results
Data from the 180 patients who were randomized were analyzed. Both self-reported adherence rate and adherence rate measured by tablet counts were not different at every points, including 1 year. The patients’ satisfaction of the OD group was higher than that of the DD group (P<0.001). At 1 year, 91.2% and 95.5% of patients in the OD group and DD group had maintained clinical remission, respectively (P=0.37).
Conclusions
The adherence rates were not different between the OD group and DD group. The patients’ satisfaction was higher in the OD group than in the DD group. 5-ASA OD dosing might have the same effect as DD for the maintenance of UC remission.

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  • Improving Medication Adherence Levels in Inflammatory Bowel Disease (IBD) Patients: A Narrative Evidence-Based Review
    Obreniokibo Amiesimaka, Kristina Aluzaite, Rhiannon Braund, Michael Schultz
    Patient Preference and Adherence.2024; Volume 18: 905.     CrossRef
  • Continuing or stopping 5‐aminosalicylates in patients with inflammatory bowel disease on anti‐TNF therapy: A nationwide population‐based study
    Jeongkuk Seo, Seonok Kim, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Dong‐Hoon Yang, Jeong‐Sik Byeon, Seung‐Jae Myung, Suk‐Kyun Yang, Ye‐Jee Kim, Byong Duk Ye
    Alimentary Pharmacology & Therapeutics.2024; 60(3): 389.     CrossRef
  • Researching Interventions to Improve Medication Adherence in Ulcerative Colitis Patients
    Mila Palma Pacheco, Flora Maria Lorenzo Fortes, Raquel Rocha dos Santos, Genoile Oliveira Santana Silva
    Journal of Coloproctology.2021; 41(01): 096.     CrossRef
  • Treatment of inflammatory bowel diseases: focusing on 5-aminosalicylates and immunomodulators
    You Sun Kim
    Journal of the Korean Medical Association.2021; 64(9): 596.     CrossRef
  • Living with ulcerative colitis in Germany: a retrospective analysis of dose escalation, concomitant treatment use and healthcare costs
    Axel Dignass, John Waller, Joseph C. Cappelleri, Irene Modesto, Agnes Kisser, Lena Dietz, Marco DiBonaventura, Robert Wood, Melanie May, Berit Libutzki, Danielle Bargo
    Journal of Medical Economics.2020; 23(4): 415.     CrossRef
  • Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis
    Alistair Murray, Tran M Nguyen, Claire E Parker, Brian G Feagan, John K MacDonald
    Cochrane Database of Systematic Reviews.2020;[Epub]     CrossRef
  • 8,014 View
  • 182 Download
  • 5 Web of Science
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Inflammatory bowel diseases
Risk of surgery in patients with stricturing type of Crohn’s disease at the initial diagnosis: a single center experience
Yuji Maehata, Yutaka Nagata, Tomohiko Moriyama, Yuichi Matsuno, Atsushi Hirano, Junji Umeno, Takehiro Torisu, Tatsuya Manabe, Takanari Kitazono, Motohiro Esaki
Intest Res 2019;17(3):357-364.   Published online February 21, 2019
DOI: https://doi.org/10.5217/ir.2018.00107
AbstractAbstract PDFPubReaderePub
Background/Aims
It remains uncertain which patients with stricturing-type Crohn’s disease (CD) require early small bowel surgery after the initial diagnosis. We aimed to clarify clinical characteristics associated with the intervention in such condition of CD.
Methods
We retrospectively evaluated the clinical course of 53 patients with CD and small bowel strictures who were initially treated with medications after the initial diagnosis. We investigated possible associations between small bowel surgery and the following: clinical factors and radiologic findings at initial diagnosis and the types of medications administered during follow-up.
Results
Twenty-eight patients (53%) required small bowel resection during a median follow-up period of 5.0 years (range, 0.5–14.3 years). The cumulative incidence rates of small bowel surgery at 2, 5, and 10 years were 26.4%, 41.0%, and 63.2%, respectively. Univariate analysis indicated that obstructive symptoms (P=0.036), long-segment stricture (P<0.0001), and prestenotic dilation (P<0.0001) on radiography were associated with small bowel surgery, and immunomodulatory (P=0.037) and biological therapy (P=0.008) were significant factors during follow-up. Multivariate analysis revealed that long-segment stricture (hazard ratio [HR], 4.25; 95% confidence interval [CI], 1.78–10.53; P=0.001) and prestenotic dilation (HR, 3.41; 95% CI, 1.24–9.62; P=0.018) on radiography showed a positive correlation with small bowel surgery, and biological therapy (HR, 0.40; 95% CI, 0.15–0.99; P=0.048) showed a negative correlation.
Conclusions
CD patients with long-segment stricture and prestenotic dilation on radiography seem to be at a higher risk of needing small bowel surgery. For such patients, early surgical intervention might be appropriate, even at initial diagnosis.

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  • Comprehensive review and update of stricturing Crohn’s disease
    Alexander T. Elford, Zaid Ardalan, Paul Simkin, Britt Christensen
    Indian Journal of Gastroenterology.2024; 43(1): 64.     CrossRef
  • A global consensus on the definitions, diagnosis and management of fibrostenosing small bowel Crohn’s disease in clinical practice
    Dominik Bettenworth, Mark E. Baker, Joel G. Fletcher, Vipul Jairath, Cathy Lu, Willem Bemelman, Geert d’Haens, Andre d’Hoore, Axel Dignass, Iris Dotan, Roger Feakins, Phillip Fleshner, Christina Ha, Gaylyn Henderson, Ruishen Lyu, Julian Panes, Gerhard Rog
    Nature Reviews Gastroenterology & Hepatology.2024; 21(8): 572.     CrossRef
  • Reliability of MR Enterography Features for Describing Fibrostenosing Crohn Disease
    Florian Rieder, Mark E. Baker, David H. Bruining, Jeff L. Fidler, Eric C. Ehman, Shannon P. Sheedy, Jay P. Heiken, Justin M. Ream, David R. Holmes, Akitoshi Inoue, Payam Mohammadinejad, Yong S. Lee, Stuart A. Taylor, Jaap Stoker, Guangyong Zou, Zhongya Wa
    Radiology.2024;[Epub]     CrossRef
  • Reliability of CT Enterography for Describing Fibrostenosing Crohn Disease
    Florian Rieder, Christopher Ma, Jurij Hanzel, Joel G. Fletcher, Mark E. Baker, Zhongya Wang, Leonardo Guizzetti, Lisa M. Shackelton, Julie Rémillard, Mihir Patel, Jiafei Niu, Ronald Ottichilo, Cynthia S. Santillan, Nunzia Capozzi, Stuart A. Taylor, David
    Radiology.2024;[Epub]     CrossRef
  • Use of oral diet and nutrition support in management of stricturing and fistulizing Crohn's disease
    Kush Fansiwala, Neha D. Shah, Kelly A. McNulty, Mary R. Kwaan, Berkeley N. Limketkai
    Nutrition in Clinical Practice.2023; 38(6): 1282.     CrossRef
  • Sarcopenia hinders the decline in disease activity after surgery for people with Crohn's disease: Preliminary results
    Asuka Yasueda, Yuki Sekido, Takashi Takeda, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Yuichiro Doki, Hidetoshi Eguchi, Tsunekazu Mizushima
    Nutrition.2022; 94: 111526.     CrossRef
  • Efficacy of drug and endoscopic treatment of Crohn's disease strictures: A systematic review
    Julien D Schulberg, Emily K Wright, Bronte A Holt, Helen E Wilding, Amy L Hamilton, Alyson L Ross, Michael A Kamm
    Journal of Gastroenterology and Hepatology.2021; 36(2): 344.     CrossRef
  • Comparison of Long-term Outcomes of Infliximab versus Adalimumab in 1,488 Biologic-Naive Korean Patients with Crohn’s Disease
    Yoon Suk Jung, Minkyung Han, Sohee Park, Jae Hee Cheon
    Gut and Liver.2021; 15(1): 92.     CrossRef
  • Molecular targets and the use of biologics in the management of small bowel fibrosis in inflammatory bowel disease
    Muaad Abdulla, Thean Soon Chew
    Current Opinion in Gastroenterology.2021; 37(3): 275.     CrossRef
  • Real world analysis on the efficacy and safety of anti-tumor necrosis factor therapy in patients with stricturing Crohn’s disease
    Sudheer K. Vuyyuru, Bhaskar Kante, Peeyush Kumar, Pabitra Sahu, Saurabh Kedia, Mukesh Kumar Ranjan, Raju Sharma, Rajesh Panwar, Govind Makharia, Vineet Ahuja
    Scientific Reports.2021;[Epub]     CrossRef
  • Inpatient Management of Inflammatory Bowel Disease-Related Complications
    Manreet Kaur, Robin L. Dalal, Seth Shaffer, David A. Schwartz, David T. Rubin
    Clinical Gastroenterology and Hepatology.2020; 18(6): 1346.     CrossRef
  • Surgical treatment of intestinal stricture in inflammatory bowel disease
    Helen M. Mohan, John C. Coffey
    Journal of Digestive Diseases.2020; 21(6): 355.     CrossRef
  • 6,791 View
  • 178 Download
  • 10 Web of Science
  • 12 Crossref
Close layer
Inflammatory bowel diseases
Real-time data monitoring for ulcerative colitis: patient perception and qualitative analysis
Alissa Walsh, Lawrence Matini, Christopher Hinds, Vanashree Sexton, Oliver Brain, Satish Keshav, John Geddes, Guy Goodwin, Gary Collins, Simon Travis, Michele Peters
Intest Res 2019;17(3):365-374.   Published online May 31, 2019
DOI: https://doi.org/10.5217/ir.2018.00173
AbstractAbstract PDFPubReaderePub
Background/Aims
TrueColours ulcerative colitis (TCUC) is a comprehensive web-based program that functions through email, providing direct links to questionnaires. Several similar programs are available, however patient perspectives are unexplored.
Methods
A pilot study was conducted to determine feasibility, usability and patient perceptions of real-time data collection (daily symptoms, fortnightly quality of life, 3 monthly outcomes). TCUC was adapted from a web-based program for patients with relapsing-remitting bipolar disorder, using validated UC indices. A semi-structured interview was developed and audio-recorded face-to-face interviews were conducted after 6 months of interaction with TCUC. Transcripts were coded in NVivo11, a qualitative data analysis software package. An inductive approach and thematic analysis was conducted.
Results
TCUC was piloted in 66 patients for 6 months. Qualitative analysis currently defies statistical appraisal beyond “data saturation,” even if it has more influence on clinical practice than quantitative data. A total of 28 face-to-face interviews were conducted. Six core themes emerged: awareness, control, decision-making, reassurance, communication and burden of treatment. There was a transcending overarching theme of patient empowerment, which cut across all aspects of the TCUC experience.
Conclusions
Patient perception of the impact of real-time data collection was extremely positive. Patients felt empowered as a product of the self-monitoring format of TCUC, which may be a way of improving self-management of UC whilst also decreasing the burden on the individual and healthcare services.

Citations

Citations to this article as recorded by  
  • Investigating Patient Perspectives on Using eHealth Technologies for the Self-Management of Inflammatory Bowel Disease: Mixed Methods Study
    Sander Hermsen, Danielle Tump, Eva Wentink, Marjolijn Duijvestein
    Journal of Medical Internet Research.2024; 26: e53512.     CrossRef
  • The body as an obstacle and the “other”. How patients with chronic inflammatory bowel diseases view their body, self and the good life
    Anke Erdmann, Christoph Rehmann-Sutter, Florian Schrinner, Claudia Bozzaro
    BMC Medical Ethics.2024;[Epub]     CrossRef
  • Development of the Escalation of Therapy or Intervention (ETI) Calculator for Patients with Ulcerative Colitis Using ePROMs
    Lawrence Matini, Thomas P Chapman, Ramona Kantschuster, Jean Wilson, Adib Tarafdar, Moheez Hussain, Kaiyang Song, Daniel M Simadibrata, Pavetha Seeva, Lydia White, Jessica Slater, Andrey Kormilitzin, Gary Collins, Simon P L Travis, Alissa Walsh
    Journal of Crohn's and Colitis.2023; 17(11): 1744.     CrossRef
  • Deep learning model for distinguishing Mayo endoscopic subscore 0 and 1 in patients with ulcerative colitis
    Ji Eun Kim, Yoon Ho Choi, Yeong Chan Lee, Gyeol Seong, Joo Hye Song, Tae Jun Kim, Eun Ran Kim, Sung Noh Hong, Dong Kyung Chang, Young-Ho Kim, Soo-Yong Shin
    Scientific Reports.2023;[Epub]     CrossRef
  • Patient-reported Outcomes: the ICHOM Standard Set for Inflammatory Bowel Disease in Real-life Practice Helps Quantify Deficits in Current Care
    Darren Wong, Lawrence Matini, Andrey Kormilitzin, Ramona Kantschuster, Daniel Martin Simadibrata, Sara Lyden, Jean Wilson, Oliver A Brain, Rebecca Palmer, Tim Ambrose, Jack Satsangi, Matthew South, John Geddes, Keith Bodger, Simon P L Travis, Alissa Walsh
    Journal of Crohn's and Colitis.2022; 16(12): 1874.     CrossRef
  • Analysis of the Current Situation of Teaching and Learning of Ideological and Political Theory Courses by Deep Learning
    Jin Chao, Yijiang Zhang, Arpit Bhardwaj
    Computational Intelligence and Neuroscience.2022; 2022: 1.     CrossRef
  • Ulcerative Colitis Narrative Global Survey Findings: Communication Gaps and Agreements Between Patients and Physicians
    David T Rubin, Ailsa Hart, Remo Panaccione, Alessandro Armuzzi, Ulla Suvanto, J Jasper Deuring, John Woolcott, Joseph C Cappelleri, Kathy Steinberg, Laura Wingate, Stefan Schreiber
    Inflammatory Bowel Diseases.2021; 27(7): 1096.     CrossRef
  • Telehealth and mobile health interventions in adults with inflammatory bowel disease: A mixed‐methods systematic review
    Suja P. Davis, Megan Suzanne Hardin Ross, Reuben Adatorwovor, Holly Wei
    Research in Nursing & Health.2021; 44(1): 155.     CrossRef
  • COVID-19 and Gastrointestinal Disease: Implications for the Gastroenterologist
    Richard H. Hunt, James E. East, Angel Lanas, Peter Malfertheiner, Jack Satsangi, Carmelo Scarpignato, Gwilym J. Webb
    Digestive Diseases.2021; 39(2): 119.     CrossRef
  • The True Colours Remote Symptom Monitoring System: A Decade of Evolution
    Sarah M Goodday, Lauren Atkinson, Guy Goodwin, Kate Saunders, Matthew South, Clare Mackay, Mike Denis, Chris Hinds, Mary-Jane Attenburrow, Jim Davies, James Welch, William Stevens, Karen Mansfield, Juulia Suvilehto, John Geddes
    Journal of Medical Internet Research.2020; 22(1): e15188.     CrossRef
  • Developments and challenges of e-health strategies for people with inflammatory bowel disease
    Pearl Avery
    British Journal of Healthcare Management.2020; 26(3): 73.     CrossRef
  • Pathogenesis and clinical perspectives of extraintestinal manifestations in inflammatory bowel diseases
    Jung Min Kim, Jae Hee Cheon
    Intestinal Research.2020; 18(3): 249.     CrossRef
  • The UK IBD Registry COVID-19 Risk Tool; Patient Generated Data Can Improve the Hospital Record
    Nicholas A. Kennedy, Naila Arebi, Keith Bodger, Vida Cairnes, R. Fraser Cummings, Liz Dobson, Stephen Grainger, Paul Harrow, A. Barney Hawthorne, Gareth-Rhys Jones, Alexandra Kent, Shaji Sebastian, Christian Selinger, Gareth J. Walker, Lisa Younge, Stuart
    SSRN Electronic Journal .2020;[Epub]     CrossRef
  • 63,624 View
  • 130 Download
  • 13 Web of Science
  • 13 Crossref
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Inflammatory bowel diseases
Efficacy and safety of abrilumab, an α4β7 integrin inhibitor, in Japanese patients with moderate-to-severe ulcerative colitis: a phase II study
Toshifumi Hibi, Satoshi Motoya, Toshifumi Ashida, Souken Sai, Yukinori Sameshima, Shiro Nakamura, Atsuo Maemoto, Masahiro Nii, Barbara A Sullivan, Robert A. Gasser Jr, Yasuo Suzuki
Intest Res 2019;17(3):375-386.   Published online February 12, 2019
DOI: https://doi.org/10.5217/ir.2018.00141
AbstractAbstract PDFPubReaderePub
Background/Aims
Inhibition of α4β7 integrin has been shown to be effective for induction and maintenance therapy in patients with ulcerative colitis (UC). We investigated the effects of varying doses of the α4β7 inhibitor abrilumab in Japanese patients with moderate-to-severe UC despite conventional treatments.
Methods
In this randomized, double-blind, placebocontrolled study, 45 UC patients were randomized to abrilumab 21 mg (n=11), 70 mg (n=12), 210 mg (n=9), or placebo (n=13) via subcutaneous (SC) injection for 12 weeks. The double-blind period was followed by a 36-week open-label period, in which all patients received abrilumab 210 mg SC every 12 weeks, and a 28-week safety follow-up period. The primary efficacy variable was clinical remission at week 8 (total Mayo score ≤2 points with no individual subscore >1 point).
Results
Clinical remission at week 8 was 4 out of 31 (12.9%) overall in the abrilumab groups versus 0 out of 13 in the placebo group (abrilumab 21 mg, 1/10 [10.0%]; 70 mg, 2/12 [16.7%]; 210 mg, 1/9 [11.1%]). In both the double-blind and open-label periods, fewer patients in the abrilumab groups experienced ≥1 adverse event compared with those in the placebo group. There were no cases of progressive multifocal leukoencephalopathy and no deaths.
Conclusions
Abrilumab 70 mg and 210 mg yielded numerically better results in terms of clinical remission rate at Week 8 than placebo, with the 210 mg dose showing more consistent treatment effects. Abrilumab was well tolerated in Japanese patients with UC.

Citations

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  • Drug-Induced Progressive Multifocal Leukoencephalopathy (PML): A Systematic Review and Meta-Analysis
    Lorenzo Vittorio Rindi, Drieda Zaçe, Neva Braccialarghe, Barbara Massa, Virginia Barchi, Roberta Iannazzo, Ilenia Fato, Francesco De Maria, Dimitra Kontogiannis, Vincenzo Malagnino, Loredana Sarmati, Marco Iannetta
    Drug Safety.2024; 47(4): 333.     CrossRef
  • Targeting integrin pathways: mechanisms and advances in therapy
    Xiaocong Pang, Xu He, Zhiwei Qiu, Hanxu Zhang, Ran Xie, Zhiyan Liu, Yanlun Gu, Nan Zhao, Qian Xiang, Yimin Cui
    Signal Transduction and Targeted Therapy.2023;[Epub]     CrossRef
  • Emerging drugs for the treatment of moderately to severely active ulcerative colitis: review of phase II and III clinical trials
    Laura Neurath, Ferdinando D’Amico, Silvio Danese
    Expert Opinion on Emerging Drugs.2023; 28(1): 27.     CrossRef
  • Inflammatory Bowel Disease: Emerging Therapies and Future Treatment Strategies
    Elisabetta Bretto, Davide Giuseppe Ribaldone, Gian Paolo Caviglia, Giorgio Maria Saracco, Elisabetta Bugianesi, Simone Frara
    Biomedicines.2023; 11(8): 2249.     CrossRef
  • Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities
    Siyi Li, Chibuzo Sampson, Changhao Liu, Hai-long Piao, Hong-Xu Liu
    Cell Communication and Signaling.2023;[Epub]     CrossRef
  • Immunology of Inflammatory Bowel Disease: Molecular Mechanisms and Therapeutics
    Quan Lu, Mei-feng Yang, Yu-jie Liang, Jing Xu, Hao-ming Xu, Yu-qiang Nie, Li-sheng Wang, Jun Yao, De-feng Li
    Journal of Inflammation Research.2022; Volume 15: 1825.     CrossRef
  • Factors predicting clinical and endoscopic remission with placebo therapy in East Asian patients with ulcerative colitis: a systematic review and meta-analysis
    Jian Zeng, Zhong Wang, Xiao-Jun Yang
    European Journal of Clinical Pharmacology.2022; 78(7): 1069.     CrossRef
  • Tackling Inflammatory Bowel Diseases: Targeting Proinflammatory Cytokines and Lymphocyte Homing
    Yijie Song, Man Yuan, Yu Xu, Hongxi Xu
    Pharmaceuticals.2022; 15(9): 1080.     CrossRef
  • Targeting Immune Cell Trafficking – Insights From Research Models and Implications for Future IBD Therapy
    Maximilian Wiendl, Emily Becker, Tanja M. Müller, Caroline J. Voskens, Markus F. Neurath, Sebastian Zundler
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Anti-Integrins for the Treatment of Inflammatory Bowel Disease: Current Evidence and Perspectives
    John Gubatan, Kian Keyashian, Samuel JS Rubin, Jenny Wang, Cyrus Buckman, Sidhartha Sinha
    Clinical and Experimental Gastroenterology.2021; Volume 14: 333.     CrossRef
  • Anti-integrin drugs in clinical trials for inflammatory bowel disease (IBD): insights into promising agents
    Virginia Solitano, Tommaso Lorenzo Parigi, Elisa Ragaini, Silvio Danese
    Expert Opinion on Investigational Drugs.2021; 30(10): 1037.     CrossRef
  • Efficacy and safety of a new vedolizumab subcutaneous formulation in Japanese patients with moderately to severely active ulcerative colitis
    Taku Kobayashi, Hiroaki Ito, Toshifumi Ashida, Tadashi Yokoyama, Masakazu Nagahori, Tomoki Inaba, Mitsuhiro Shikamura, Takayoshi Yamaguchi, Tetsuharu Hori, Philippe Pinton, Mamoru Watanabe, Toshifumi Hibi
    Intestinal Research.2021; 19(4): 448.     CrossRef
  • Emerging therapeutic options in inflammatory bowel disease
    Jesus K Yamamoto-Furusho, Norma N Parra-Holguín
    World Journal of Gastroenterology.2021; 27(48): 8242.     CrossRef
  • Subcutaneous integrin inhibitors may provide more treatment options for patients with moderate-to-severe ulcerative colitis
    Hyuk Yoon
    Intestinal Research.2019; 17(3): 283.     CrossRef
  • 7,141 View
  • 197 Download
  • 15 Web of Science
  • 14 Crossref
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Inflammatory bowel diseases
Quantitative histology-based classification system for assessment of the intestinal mucosal histological changes in patients with celiac disease
Prasenjit Das, Gaurav PS Gahlot, Alka Singh, Vandana Baloda, Ramakant Rawat, Anil K Verma, Gaurav Khanna, Maitrayee Roy, Archana George, Ashok Singh, Aasma Nalwa, Prashant Ramteke, Rajni Yadav, Vineet Ahuja, Vishnubhatla Sreenivas, Siddhartha Datta Gupta, Govind K Makharia
Intest Res 2019;17(3):387-397.   Published online April 22, 2019
DOI: https://doi.org/10.5217/ir.2018.00167
AbstractAbstract PDFPubReaderePub
Background/Aims
The existing histological classifications for the interpretation of small intestinal biopsies are based on qualitative parameters with high intraobserver and interobserver variations. We have developed and propose a quantitative histological classification system for the assessment of intestinal mucosal biopsies.
Methods
We performed a computer-assisted quantitative histological assessment of digital images of duodenal biopsies from 137 controls and 124 patients with celiac disease (CeD) (derivation cohort). From the receiver-operating curve analysis, followed by multivariate and logistic regression analyses, we identified parameters for differentiating control biopsies from those of the patients with CeD. We repeated the quantitative histological analysis in a validation cohort (105 controls and 120 patients with CeD). On the basis of the results, we propose a quantitative histological classification system. The new classification was compared with the existing histological classifications for interobserver and intraobserver agreements by a group of qualified pathologists.
Results
Among the histological parameters, intraepithelial lymphocyte count of ≥25/100 epithelial cells, adjusted villous height fold change of ≤0.7, and crypt depth-to-villous height ratio of ≥0.5 showed good discriminative power between the mucosal biopsies from the patients with CeD and those from the controls, with 90.3% sensitivity, 93.5% specificity, and 96.2% area under the curve. Among the existing histological classifications, our quantitative histological classification showed the highest intraobserver (69.7%–85.03%) and interobserver (24.6%–71.5%) agreements.
Conclusions
Quantitative assessment increases the reliability of the histological assessment of mucosal biopsies in patients with CeD. Such a classification system may be used for clinical trials in patients with CeD. (Intest Res, Published online)

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  • Celiac Disease Deep Learning Image Classification Using Convolutional Neural Networks
    Joaquim Carreras
    Journal of Imaging.2024; 10(8): 200.     CrossRef
  • CD, or not CD, that is the question: a digital interobserver agreement study in coeliac disease
    James Denholm, Benjamin A Schreiber, Florian Jaeckle, Mike N Wicks, Emyr W Benbow, Tim S Bracey, James Y H Chan, Lorant Farkas, Eve Fryer, Kishore Gopalakrishnan, Caroline A Hughes, Kathryn J Kirkwood, Gerald Langman, Betania Mahler-Araujo, Raymond F T Mc
    BMJ Open Gastroenterology.2024; 11(1): e001252.     CrossRef
  • Role of Serology, Dietary Assessment, and Fecal Gluten Immunogenic Peptides for Predicting Histologic Recovery in Children with Celiac Disease
    Keerthivasan Seetharaman, Sadhna Bhasin Lal, Kaushal Kishor Prasad, Yashwant Kumar, Alka Bhatia, Sunita Malhotra
    Digestive Diseases and Sciences.2023; 68(2): 529.     CrossRef
  • Usefulness of a double immunofluorescence technique for detection of intestinal tTG-IgA deposits in diabetic and non-diabetic children with celiac disease
    Raghav Lal, Ranjeet Bhardwaj, Ranjana Walker Minz, Kaushal Kishore Prasad, Sadhna Lal, Devi Dayal, Yashwant Kumar
    Pediatrics & Neonatology.2023; 64(4): 388.     CrossRef
  • The global burden of coeliac disease: opportunities and challenges
    Govind K. Makharia, Prashant Singh, Carlo Catassi, David S. Sanders, Daniel Leffler, Raja Affendi Raja Ali, Julio C. Bai
    Nature Reviews Gastroenterology & Hepatology.2022; 19(5): 313.     CrossRef
  • Gluten Induces Subtle Histological Changes in Duodenal Mucosa of Patients with Non-Coeliac Gluten Sensitivity: A Multicentre Study
    Kamran Rostami, Arzu Ensari, Michael N. Marsh, Amitabh Srivastava, Vincenzo Villanacci, Antonio Carroccio, Hamid Asadzadeh Aghdaei, Julio C. Bai, Gabrio Bassotti, Gabriel Becheanu, Phoenix Bell, Camillo Di Bella, Anna Maria Bozzola, Moris Cadei, Giovanni
    Nutrients.2022; 14(12): 2487.     CrossRef
  • The Role of Nerve Fibers in the Tumor Immune Microenvironment of Solid Tumors
    Sharia Hernandez, Alejandra G. Serrano, Luisa M. Solis Soto
    Advanced Biology.2022;[Epub]     CrossRef
  • Case Report: Morphologic and Functional Characteristics of Intestinal Mucosa in a Child With Short Bowel Syndrome After Treatment With Teduglutide: Evidence in Favor of GLP-2 Analog Safety
    Enrico Costantino Falco, Antonella Lezo, Pierluigi Calvo, Caterina Rigazio, Anna Opramolla, Ludovica Verdun, Giovanna Cenacchi, Marianna Pellegrini, Marco Spada, Gabriella Canavese
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Quantitative histology as a diagnostic tool for celiac disease in children and adolescents
    Mateus M. Vargas, Ricardo Artigiani Neto, Vera L. Sdepanian
    Annals of Diagnostic Pathology.2022; 61: 152031.     CrossRef
  • Best practices of handling, processing, and interpretation of small intestinal biopsies for the diagnosis and management of celiac disease: A joint consensus of Indian association of pathologists and microbiologists and Indian society of gastroenterology
    Prasenjit Das, Kim Vaiphei, AnjaliD Amarapurkar, Puja Sakhuja, Ritambhra Nada, RoopaRachel Paulose, Rachana Chaturvedi, Anuradha Sekaran, Usha Kini, Archana Rastogi, Niraj Kumari, Anna Pulimood, Mala Banerjee, Prateek Kinra, Lavleen Singh, AmarenderSingh
    Indian Journal of Pathology and Microbiology.2021; 64(5): 8.     CrossRef
  • Artificial intelligence in small intestinal diseases: Application and prospects
    Yu Yang, Yu-Xuan Li, Ren-Qi Yao, Xiao-Hui Du, Chao Ren
    World Journal of Gastroenterology.2021; 27(25): 3734.     CrossRef
  • Opportunities and challenges in the management of celiac disease in Asia
    Ashish Agarwal, Ashish Chauhan, Vineet Ahuja, Govind K Makharia
    JGH Open.2020; 4(5): 795.     CrossRef
  • Digital histology in celiac disease: A practice changer
    Daniel Vasile Balaban, Mariana Jinga
    Artificial Intelligence in Gastroenterology.2020; 1(1): 1.     CrossRef
  • Digital histology in celiac disease: A practice changer
    Daniel Vasile Balaban, Mariana Jinga
    Artificial Intelligence in Gastroenterology.2020; 1(1): 1.     CrossRef
  • 7,455 View
  • 177 Download
  • 13 Web of Science
  • 14 Crossref
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Colorectal neoplasia
Endoscopic features of gastrointestinal stromal tumor in the small intestine
Yutaro Ihara, Takehiro Torisu, Tomohiko Moriyama, Junji Umeno, Atsushi Hirano, Yasuharu Okamoto, Yoshifumi Hori, Hidetaka Yamamoto, Takanari Kitazono, Motohiro Esaki
Intest Res 2019;17(3):398-403.   Published online July 25, 2019
DOI: https://doi.org/10.5217/ir.2018.00161
AbstractAbstract PDFPubReaderePub
Background/Aims
Gastrointestinal stromal tumor (GIST) is one of the most common types of submucosal tumors (SMTs). Because of GIST’s malignant potential, it is crucial to differentiate it from other SMTs. The present study aimed to identify characteristic endoscopic findings of GISTs in the small intestine.
Methods
We reviewed the clinicopathological and endoscopic findings of 38 patients with endoscopically or surgically resected SMTs in the small intestine. SMTs were classified into GIST and non-GIST groups, and clinicopathological and endoscopic findings were compared between the 2 groups.
Results
Fifteen patients had GIST and 23 patients had other types of SMTs in the small intestine. Comparison of the endoscopic findings between the 2 groups revealed that dilated vessels in the surrounding mucosa were significantly more in number in the GIST group than in the non-GIST group (P<0.05). However, there were no other differences in endoscopic findings between the 2 groups. Among patients with GISTs, the presence of dilated vessels in the surrounding mucosa was not associated with bleeding risk, tumor size, or metastasis rate at diagnosis.
Conclusions
Dilated vessels in the surrounding mucosa, identified during balloon-assisted endoscopy, may be a diagnostic indicator for GIST in the small intestine. However, its clinical significance should be further analyzed.

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  • Multiple Small Bowel Gastrointestinal Stromal Tumors Associated with Neurofibromatosis Type 1 that Were Not Detected by Endoscopy: A Case Report
    Satomi Saito, Teppei Omori, Shun Murasugi, Maria Yonezawa, Yukiko Takayama, Takeshi Ohki, Hiromi Onizuka, Yoji Nagashima, Katsutoshi Tokushige
    Case Reports in Gastroenterology.2023; 17(1): 167.     CrossRef
  • Convolutional neural network‐based object detection model to identify gastrointestinal stromal tumors in endoscopic ultrasound images
    Chang Kyo Oh, Taewan Kim, Yu Kyung Cho, Dae Young Cheung, Bo‐In Lee, Young‐Seok Cho, Jin Il Kim, Myung‐Gyu Choi, Han Hee Lee, Seungchul Lee
    Journal of Gastroenterology and Hepatology.2021; 36(12): 3387.     CrossRef
  • Small Bowel Malignancies in Patients Undergoing Capsule Endoscopy for Iron Deficiency Anemia
    Su Hwan Kim, Ji Won Kim
    Diagnostics.2021; 12(1): 91.     CrossRef
  • 7,302 View
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Colorectal neoplasia
Association of visceral adiposity and insulin resistance with colorectal adenoma and colorectal cancer
In Sub Jung, Cheol Min Shin, Sung Jae Park, Young Soo Park, Hyuk Yoon, Hyun Jin Jo, Nayoung Kim, Dong Ho Lee
Intest Res 2019;17(3):404-412.   Published online November 12, 2018
DOI: https://doi.org/10.5217/ir.2018.00072
AbstractAbstract PDFPubReaderePub
Background/Aims
To examine whether visceral adiposity serves as a risk factor for colorectal cancer (CRC) and colorectal adenomas.
Methods
Two hundred healthy subjects, 200 patients with colorectal adenoma, and 151 patients with CRC (46 with early-stage and 105 with advanced-stage cancers) were enrolled at a tertiary referral hospital. All subjects underwent colonoscopy, and had laboratory data, and computed tomography (CT) scan available for abdominal fat measurement. An abdominal CT scan taken 1 to 4 years (mean interval, 20.6 months) before the diagnosis of CRC was also available in the 42 CRC patients.
Results
The mean areas of visceral adipose tissue (VAT) areas in the control, adenoma, early- and advanced-stage CRC groups were 94.6, 116.8, 110.4, and 99.7 cm2 , respectively (P<0.001). The risk of adenoma positively correlated with VAT area and the visceral-to-total fat ratio (P for trend <0.01), but the risk of CRC did not (P>0.05). The risk of both adenoma and CRC positively correlated with fasting plasma glucose levels (P for trend <0.05). In patients with early-stage cancer (n=17), VAT area decreased when the CT scan at diagnosis was compared with that taken before the diagnosis of CRC, but superficial adipose tissue area did not, so visceral-to-total fat ratio significantly decreased (46.6% vs. 50.7%, respectively, P=0.018)
Conclusions
VAT area is related to the risk of colorectal adenoma. However, VAT decreases from the early stages of CRC. Impaired fasting glucose has a role in colorectal carcinogenesis.

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  • Change in abdominal obesity after colon cancer surgery – effects of left-sided and right-sided colonic resection
    Younes Kays Mohammed Ali, Troels Gammeltoft Dolin, Janus Damm Nybing, Jakob Lykke, Frederik Hvid Linden, Erik Høgh-Schmidt, Thorkild I. A. Sørensen, Jesper Frank Christensen, Yousef J. W. Nielsen, Jim Stenfatt Larsen, Sten Madsbad, Julia Sidenius Johansen
    International Journal of Obesity.2024; 48(4): 533.     CrossRef
  • Research Progress on the Correlation between Metabolic Syndrome and Colorectal Polyps
    欣然 王
    Advances in Clinical Medicine.2024; 14(03): 1733.     CrossRef
  • MAFLD with central obesity is associated with increased risk of colorectal adenoma and high-risk adenoma
    Jingfang Xiong, Yijun Wu, Dongya Chen, Zhaolin Zhang, Yihui Liu, Jiandong Luo, Hong Xu
    BMC Gastroenterology.2024;[Epub]     CrossRef
  • Association between Atherosclerosis and High-Risk Colorectal Adenomas based on Cardio-Ankle Vascular Index and Ankle-Brachial Index
    Jung Ho Lee, Hyunseok Cho, Sang Hoon Lee, Sung Joon Lee, Chang Don Kang, Dae Hee Choi, Jin Myung Park, Seung-Joo Nam, Tae Suk Kim, Ji Hyun Kim, Sung Chul Park
    The Korean Journal of Gastroenterology.2024; 83(4): 143.     CrossRef
  • Hot Spots and Trends in the Relationship between Cancer and Obesity: A Systematic Review and Knowledge Graph Analysis
    Le Gao, Tian Yang, Ziru Xue, Chak Kwan Dickson Chan
    Life.2023; 13(2): 337.     CrossRef
  • Abdominal fat and muscle distributions in different stages of colorectal cancer
    Jun Han, Xinyang Liu, Min Tang, Fan Yang, Zuoyou Ding, Guohao Wu
    BMC Cancer.2023;[Epub]     CrossRef
  • Arterial stiffness is associated with high-risk colorectal adenomas and serrated lesions: A cross-sectional study in a Taiwanese population
    Hung-Yu Chen, Wen-Huang Lee, Hung-Lung Hsu, Yu-Tsung Chou, Fei-Lin Su, I-Hsuan Wu, Ting-Hsing Chao
    Journal of Cardiology.2022; 80(2): 139.     CrossRef
  • Relationship between BMI, CT-derived body composition and colorectal neoplasia in a bowel screening population
    Domenic G. Di Rollo, Josh McGovern, Christopher Morton, Gillian Miller, Ross Dolan, Paul G. Horgan, Donald C. McMillan, David Mansouri
    Scottish Medical Journal.2022; 67(3): 93.     CrossRef
  • Review article: obesity and colorectal cancer
    Marc Bardou, Alexia Rouland, Myriam Martel, Romaric Loffroy, Alan N. Barkun, Nicolas Chapelle
    Alimentary Pharmacology & Therapeutics.2022; 56(3): 407.     CrossRef
  • The Association of Waist Circumference with the Prevalence and Survival of Digestive Tract Cancer in US Adults: A Population Study Based on Machine Learning Methods
    Xingyu Jiang, Qi Liang, Huanhuan Xu, Shouyong Gu, Lingxiang Liu, Jincheng Wang
    Computational and Mathematical Methods in Medicine.2022; 2022: 1.     CrossRef
  • Obesity Is Not an Independent Predictor of Necrotizing Soft Tissue Infection Outcomes
    Hannah Zhao-Fleming, Mhd Hasan Almekdash, Elizabeth Cook, Armand Northcut, Diana Mitchell, Kendra Rumbaugh, Sharmila Dissanaike
    Surgical Infections.2021; 22(2): 187.     CrossRef
  • Optimization of the surveillance strategy in patients with colorectal adenomas: A combination of clinical parameters and index colonoscopy findings
    Chan Hyuk Park, Yoon Suk Jung, Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn
    Journal of Gastroenterology and Hepatology.2021; 36(4): 974.     CrossRef
  • Obesity, sleep apnea, and cancer
    Isaac Almendros, Miguel A. Martinez-Garcia, Ramon Farré, David Gozal
    International Journal of Obesity.2020; 44(8): 1653.     CrossRef
  • Opportunistic use of radiological measures of visceral adiposity for assessment of risk of colorectal adenoma
    Zi Qin Ng, Ruwan Wijesuriya, Philip Misur, Jih Huei Tan, Kyaw Soe Moe, Mary Theophilus
    ANZ Journal of Surgery.2020; 90(11): 2298.     CrossRef
  • Changes in Abdominal Obesity Affect the Risk of Metachronous Advanced Colorectal Neoplasia Development after Polypectomy
    Yoon Suk Jung, Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn
    Yonsei Medical Journal.2020; 61(7): 579.     CrossRef
  • 39,734 View
  • 179 Download
  • 15 Web of Science
  • 15 Crossref
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Endoscopy
Clinical comparison of low-volume agents (oral sulfate solution and sodium picosulfate with magnesium citrate) for bowel preparation: the EASE study
Jeeyeon Kim, Hyun Gun Kim, Kyeong Ok Kim, Hyung Wook Kim, Jongha Park, Jeong-Sik Byeon, Sung-Wook Hwang, Hyun Deok Shin, Jeong Eun Shin, Hyo-Joon Yang, Hyun Seok Lee, Yunho Jung, Young-Seok Cho, Young Eun Joo, Dae-Seong Myung, Kyu Chan Huh, Eu Mi Ahn
Intest Res 2019;17(3):413-418.   Published online April 8, 2019
DOI: https://doi.org/10.5217/ir.2018.00156
AbstractAbstract PDFPubReaderePub
Background/Aims
This study compared the efficacy, compliance, and safety of bowel preparation between sodium picosulfate with magnesium citrate (SPMC) and oral sulfate solution (OSS).
Methods
A prospective randomized multicenter study was performed. Split preparation methods were performed in both groups; the SPMC group, 2 sachets on the day before, and 1 sachet on the day of the procedure, the OSS group, half of the OSS with 1 L of water on both the day before and the day of the procedure. The adenoma detection rate (ADR), adequacy of bowel preparation using the Boston Bowel Preparation Scale (BBPS) score, patient satisfaction on a visual analog scale (VAS), and safety were compared between the 2 groups.
Results
This study analyzed 229 patients (121 in the SPMC group and 108 in the OSS group). ADR showed no differences between 2 groups (51.7% vs. 41.7%, P> 0.05). The mean total BBPS score (7.95 vs. 8.11, P> 0.05) and adequate bowel preparation rate (94.9% vs. 96.3%, P> 0.05) were similar between the 2 groups. The mean VAS score for taste (7.62 vs. 6.87, P=0.006) was significantly higher in the SPMC group than in the OSS group. There were no significant differences in any other safety variables between the 2 groups except nausea symptom (36.1% vs. 20.3%, P=0.008).
Conclusions
Bowel preparation for colonoscopy using low volume OSS and SPMC yielded similar ADRs and levels of efficacy. SPMC had higher levels of satisfaction for taste and feeling than did OSS.

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  • Comments on Oral Sulfate Solution Is as Effective as Polyethylene Glycol with Ascorbic Acid in a Split Method for Bowel Preparation in Patients with Inactive Ulcerative Colitis: A Randomized, Multicenter, and Single-Blind Clinical Trial
    Ji Eun Kim
    Gut and Liver.2024; 18(1): 192.     CrossRef
  • Oral Sulfate Solution Is as Effective as Polyethylene Glycol with Ascorbic Acid in a Split Method for Bowel Preparation in Patients with Inactive Ulcerative Colitis: A Randomized, Multicenter, and Single-Blind Clinical Trial
    Ji Min Lee, Kang-Moon Lee, Ho Suk Kang, Ja Seol Koo, Hyun Seok Lee, Seok-Hoo Jeong, Jung Ho Kim, Dae Bum Kim
    Gut and Liver.2023; 17(4): 591.     CrossRef
  • Quality indicators in colonoscopy: the chasm between ideal and reality
    Su Bee Park, Jae Myung Cha
    Clinical Endoscopy.2022; 55(3): 332.     CrossRef
  • Comparison of the efficacy and safety between oral sulfate tablet and polyethylene glycol for bowel preparation before colonoscopy according to age
    Jae Hyun Kim, Yong Eun Park, Tae Oh Kim, Jongha Park, Gyu Man Oh, Won Moon, Seun Ja Park
    Medicine.2022; 101(27): e29884.     CrossRef
  • Efficacy, safety and tolerability of oral sulphate tablet for bowel preparation in patients with inflammatory bowel disease: A multicentre randomized controlled study
    Kyeong Ok Kim, Eun Young Kim, Yoo Jin Lee, Hyun Seok Lee, Eun Soo Kim, Yun Jin Chung, Byung Ik Jang, Sung Kook Kim, Chang Heon Yang
    Journal of Crohn's and Colitis.2022; 16(11): 1706.     CrossRef
  • Comparison of Two Types of 1-L Polyethylene Glycol-ascorbic Acid as Colonoscopic Bowel Preparation: A Prospective Randomized Study
    Suh Hyun Choi, Won Eui Yoon, Seung Hyuk Kim, Hee Jun Myung, Seo Hyun Kim, Soon Oh So, Se Hun Kim, Hyun Mi Lee, Yeoun Jung Oh, Jeong Seop Moon, Tae Yeong Park, You Sun Kim
    The Korean Journal of Gastroenterology.2022; 80(2): 85.     CrossRef
  • Correlation between Surrogate Quality Indicators for Adenoma Detection Rate and Adenoma Miss Rate in Qualified Colonoscopy, CORE Study: KASID Multicenter Study
    Jae Hee Han, Hyun Gun Kim, Eu Mi Ahn, Suyeon Park, Seong Ran Jeon, Jae Myung Cha, Min Seob Kwak, Yunho Jung, Jeong Eun Shin, Hyun Deok Shin, Young-Seok Cho
    Gut and Liver.2022; 16(5): 716.     CrossRef
  • How to Choose the Optimal Bowel Preparation Regimen for Colonoscopy
    Ji Eun Na, Eun Ran Kim
    The Ewha Medical Journal.2021; 44(4): 122.     CrossRef
  • Optimal Laxatives for Oral Colonoscopy Bowel Preparation: from High-volume to Novel Low-volume Solutions
    Soo-Young Na, Won Moon
    The Korean Journal of Gastroenterology.2020; 75(2): 65.     CrossRef
  • No inferioridad entre dos agentes de bajo volumen (Picosulfato de Sodio/Citrato de Magnesio vs. Sulfato de Sodio/Potasio/Magnesio) en la preparación de colon para procedimientos diagnósticos: estudio observacional
    Erika D. Pérez-Riveros, Margarita Rey R., Belén Mendoza De Molano, Juan Carlos Robayo, Jaime Solano Mariño, Rafael García Duperly, Andrés Gómez, Renzo Pinto Carta, Gerardo Ardila, Jose De la Hoz-Valle, Fernando Sierra-Arango
    Revista Colombiana de Gastroenterología.2020; 35(4): 436.     CrossRef
  • 7,574 View
  • 250 Download
  • 9 Web of Science
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Functional bowel disorders
Is stool frequency associated with the richness and community composition of gut microbiota?
Hye Jung Kwon, Jong Hyun Lim, Dongmin Kang, Sanghyun Lim, Seun Ja Park, Jae Hyun Kim
Intest Res 2019;17(3):419-426.   Published online February 7, 2019
DOI: https://doi.org/10.5217/ir.2018.00149
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background/Aims
Recently, a number of studies have reported that the gut microbiota could contribute to human conditions, including obesity, inflammation, cancer development, and behavior. We hypothesized that the composition and distribution of gut microbiota are different according to stool frequency, and attempted to identify the association between gut microbiota and stool frequency.
Methods
We collected fecal samples from healthy individuals divided into 3 groups according to stool frequency: group 1, a small number of defecation (≤2 times/wk); group 2, normal defecation (1 time/day or 1 time/2 day); and group 3, a large number of defecation (≥2–3 times/day). We evaluated the composition and distribution of the gut microbiota in each group via 16S rRNA-based taxonomic profiling of the fecal samples.
Results
Fecal samples were collected from a total of 60 individuals (31 men and 29 women, aged 34.1±5.88 years), and each group comprised 20 individuals. The microbial richness of group 1 was significantly higher than that of group 3 and tended to decrease with increasing number of defecation (P<0.05). The biological community composition was fairly different according to the number of defecation, and Bacteroidetes to Firmicutes ratio was higher in group 1 than in the other groups. Moreover, we found specific strains at the family and genus levels in groups 1 and 3.
Conclusions
Bacteroidetes to Firmicutes ratio and the abundance of Bifidobacterium were different according to the stool frequency, and specific bacteria were identified in the subjects with large and small numbers of defecation, respectively. These findings suggest that stool frequency might be associated with the richness and community composition of the gut microbiota.

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  • Personalized probiotic strategy considering bowel habits: impacts on gut microbiota composition and alleviation of gastrointestinal symptoms via Consti-Biome and Sensi-Biome
    Uigi Min, Yoo-Jeong Jin, You Jin Jang, Jonghyun Lim, Byung-Yong Kim
    Frontiers in Nutrition.2024;[Epub]     CrossRef
  • Deciphering the Impact of Defecation Frequency on Gut Microbiome Composition and Diversity
    Gwoncheol Park, Seongok Kim, WonJune Lee, Gyungcheon Kim, Hakdong Shin
    International Journal of Molecular Sciences.2024; 25(9): 4657.     CrossRef
  • Advancing human gut microbiota research by considering gut transit time
    Nicola Procházková, Gwen Falony, Lars Ove Dragsted, Tine Rask Licht, Jeroen Raes, Henrik M Roager
    Gut.2023; 72(1): 180.     CrossRef
  • Gut Microbiome Analysis for Personalized Nutrition: The State of Science
    Marie‐Christine Simon, Christian Sina, Paola G. Ferrario, Hannelore Daniel
    Molecular Nutrition & Food Research.2023;[Epub]     CrossRef
  • The gut-microbiota-brain axis in a Spanish population in the aftermath of the COVID-19 pandemic: microbiota composition linked to anxiety, trauma, and depression profiles
    Stefanie Malan-Müller, Mireia Valles-Colomer, Tomás Palomo, Juan C. Leza
    Gut Microbes.2023;[Epub]     CrossRef
  • Fecal microbiota transplantation in Parkinson's disease—A randomized repeat-dose, placebo-controlled clinical pilot study
    Herbert L. DuPont, Jessika Suescun, Zhi-Dong Jiang, Eric L. Brown, Heather T. Essigmann, Ashley S. Alexander, Andrew W. DuPont, Tehseen Iqbal, Netanya S. Utay, Michael Newmark, Mya C. Schiess
    Frontiers in Neurology.2023;[Epub]     CrossRef
  • Effect of Probiotic-Fortified Infant Formula on Infant Gut Health and Microbiota Modulation
    Ju Young Eor, Chul Sang Lee, Sung Ho Moon, Ju Young Cheon, Duleepa Pathiraja, Byeonghyeok Park, Min Jae Shin, Jae-Young Kim, Sangjong Kim, Youngbae Noh, Yunhan Kim, In-Geol Choi, Sae Hun Kim
    Food Science of Animal Resources.2023; 43(4): 659.     CrossRef
  • Efficacy of washed microbiota transplantation for therapeutic targets of refractory functional constipation and the influencing factors: a single-center, retrospective, 24-week follow-up study
    Liquan Wu, Qingfen Yuan, Lihao Wu, Harry Hua-Xiang Xia, Muxiao Zhong, Tao Liu, Xiaoyan Ye, Danping Luo, Jiating Xu, Wenrui Xie, Xingxiang He, Jieyi Cai
    BMC Gastroenterology.2023;[Epub]     CrossRef
  • Scarring the early-life microbiome: its potential life-long effects on human health and diseases
    Hyunji Park, Na-Young Park, Ara Koh
    BMB Reports.2023; 56(9): 469.     CrossRef
  • Frequency of Bowel Movements and Risk of Diverticulitis
    Manol Jovani, Wenjie Ma, Kyle Staller, Amit D. Joshi, Po-Hong Liu, Long H. Nguyen, Paul Lochhead, Yin Cao, Idy Tam, Kana Wu, Edward L. Giovannucci, Lisa L. Strate, Andrew T. Chan
    Clinical Gastroenterology and Hepatology.2022; 20(2): 325.     CrossRef
  • Association Between Gastrointestinal Symptoms and Depression in a Representative Sample of Adults in the United States: Findings From National Health and Nutrition Examination Survey (2005–2016)
    Sarah J. Eustis, Michael W. McCall, E. Angela Murphy, Michael D. Wirth
    Journal of the Academy of Consultation-Liaison Psychiatry.2022; 63(3): 268.     CrossRef
  • Effects of probiotics on cognitive and emotional functions in healthy older adults: Protocol for a double‐blind randomized placebo‐controlled crossover trial
    Cristofer Ruiz‐Gonzalez, Diana Cardona, Miguel Rodriguez‐Arrastia, Carmen Ropero‐Padilla, Lola Rueda‐Ruzafa, Francisca Carvajal, Nuria Sanchez‐Labraca, Adrian Aparicio Mota, Pablo Roman
    Research in Nursing & Health.2022; 45(3): 274.     CrossRef
  • Diet and Gut Microbiome and the “Chicken or Egg” Problem
    Hannelore Daniel
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Proposal of a health gut microbiome index based on a meta-analysis of Korean and global population datasets
    Hyun-Seok Oh, Uigi Min, Hyejin Jang, Namil Kim, Jeongmin Lim, Mauricio Chalita, Jongsik Chun
    Journal of Microbiology.2022; 60(5): 533.     CrossRef
  • Physical Complaints Decrease after Following a Few-Foods Diet in Children with ADHD
    Lidy Pelsser, Tim Stobernack, Klaas Frankena
    Nutrients.2022; 14(15): 3036.     CrossRef
  • Differences in gut microbiota correlate with symptoms and regional brain volumes in patients with late-life depression
    Chia-Fen Tsai, Chia-Hsien Chuang, Yen-Po Wang, Ya-Bo Lin, Pei-Chi Tu, Pei-Yi Liu, Po-Shan Wu, Chung-Yen Lin, Ching-Liang Lu
    Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
  • A Clinical Outcome of the Anti-PD-1 Therapy of Melanoma in Polish Patients Is Mediated by Population-Specific Gut Microbiome Composition
    Bernadeta Pietrzak, Katarzyna Tomela, Agnieszka Olejnik-Schmidt, Łukasz Galus, Jacek Mackiewicz, Mariusz Kaczmarek, Andrzej Mackiewicz, Marcin Schmidt
    Cancers.2022; 14(21): 5369.     CrossRef
  • Nutritional, Health and Lifestyle Status of a Highly Physically Active and Health-Conscious Long-Term Vegan Man: A Case Report from Slovenia
    Boštjan Jakše, Stanislav Pinter
    Reports.2022; 5(4): 45.     CrossRef
  • Self-Perception of Changes in Routines in Adults and Older Adults Associated to Social Distancing Due to COVID-19—A Study in São Paulo, Brazil
    Adriana Machado-Lima, Angélica Castilho Alonso, Débora Gozzo, Gisele Garcia Zanca, Guilherme Carlos Brech, José Maria Montiel, Marta Ferreira Bastos, Priscila Larcher Longo, Sandra Regina Mota-Ortiz
    Frontiers in Psychology.2021;[Epub]     CrossRef
  • Changes in gut microbiota in the acute phase after spinal cord injury correlate with severity of the lesion
    Gabriele Bazzocchi, Silvia Turroni, Maria Chiara Bulzamini, Federica D’Amico, Angelica Bava, Mirco Castiglioni, Valentina Cagnetta, Ernesto Losavio, Maurizio Cazzaniga, Laura Terenghi, Luisa De Palma, Giuseppina Frasca, Beatrice Aiachini, Sonia Cremascoli
    Scientific Reports.2021;[Epub]     CrossRef
  • Stool pattern is associated with not only the prevalence of tumorigenic bacteria isolated from fecal matter but also plasma and fecal fatty acids in healthy Japanese adults
    Daiki Watanabe, Haruka Murakami, Harumi Ohno, Kumpei Tanisawa, Kana Konishi, Kikue Todoroki-Mori, Yuta Tsunematsu, Michio Sato, Yuji Ogata, Noriyuki Miyoshi, Naoto Kubota, Jun Kunisawa, Keiji Wakabayashi, Tetsuya Kubota, Kenji Watanabe, Motohiko Miyachi
    BMC Microbiology.2021;[Epub]     CrossRef
  • Shifts in the Fecal Microbial Community of Cystoisospora suis Infected Piglets in Response to Toltrazuril
    Aruna Shrestha, Barbara U. Metzler-Zebeli, Hamadi Karembe, Daniel Sperling, Simone Koger, Anja Joachim
    Frontiers in Microbiology.2020;[Epub]     CrossRef
  • Diet and the gut microbiome: from hype to hypothesis
    Hannelore Daniel
    British Journal of Nutrition.2020; 124(6): 521.     CrossRef
  • The Microbiota Profile in Inflamed and Non-Inflamed Ileal Pouch–Anal Anastomosis
    Sabrina Just Kousgaard, Thomas Yssing Michaelsen, Hans Linde Nielsen, Karina Frahm Kirk, Mads Albertsen, Ole Thorlacius-Ussing
    Microorganisms.2020; 8(10): 1611.     CrossRef
  • 11,602 View
  • 251 Download
  • 25 Web of Science
  • 24 Crossref
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Functional bowel disorders
Evaluation of symptoms and symptom combinations in histamine intolerance
Wolfgang J. Schnedl, Sonja Lackner, Dietmar Enko, Michael Schenk, Sandra J. Holasek, Harald Mangge
Intest Res 2019;17(3):427-433.   Published online March 7, 2019
DOI: https://doi.org/10.5217/ir.2018.00152
AbstractAbstract PDFPubReaderePub
Background/Aims
Food intolerance/malabsorption, particularly histamine intolerance (HIT), may cause nonspecific functional gastrointestinal and extraintestinal symptoms. We evaluated gastrointestinal and extraintestinal symptoms in patients with HIT.
Methods
In an analysis of outpatients’ charts we identified 133 patients, who presented with recurring nonspecific functional gastrointestinal, extraintestinal symptoms, and a diamine oxidase value <10 U/mL, indicative of HIT. A standardized anonymous questionnaire with symptoms of HIT based on known symptoms and the 4 histamine receptors including gastrointestinal, cardiovascular, respiratory and skin complaints was developed, and sent by mail to the patients.
Results
In the 62 patients that completed the questionnaire bloating was the most common and most serious symptom. Other commonly reported gastrointestinal symptoms were postprandial fullness, diarrhea, abdominal pain, and constipation. The presence of 2 from a list of 24 symptoms resulted in 276 various symptom combinations. From calculated 2.024 possible combinations of 3 symptoms the patients with HIT presented 1.975 combinations.
Conclusions
The knowledge of this wide variability of symptoms and complex symptom combinations in patients with HIT may help to clinically recognize and diagnose HIT.

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  • Exploring the Relationship between Diamine Oxidase and Psychotropic Medications in Fibromyalgia Treatment, Finding No Reduction in Diamine Oxidase Levels and Activity except with Citalopram
    Yaiza Tobajas, Marc Alemany-Fornés, Iris Samarra, Jordi Romero-Giménez, Jordi Cuñé-Castellana, Maria Tintoré, Antoni del Pino, Núria Canela, Josep M. del Bas, Nàdia Ortega-Olivé, Carlos de Lecea, Xavier Escoté
    Journal of Clinical Medicine.2024; 13(3): 792.     CrossRef
  • Nahrungsmittelallergie und Histaminintoleranz
    Yurdagül Zopf, Walburga Dieterich
    Die Gastroenterologie.2024; 19(1): 3.     CrossRef
  • Prevalence and Clinical Picture of Diamine Oxidase Gene Variants in Children and Adolescents with Attention Deficit Hyperactivity Disorder: A Pilot Study
    Hilario Blasco-Fontecilla, Marcos Bella-Fernández, Ping Wang, Marina Martin-Moratinos, Chao Li
    Journal of Clinical Medicine.2024; 13(6): 1659.     CrossRef
  • Histamine intolerance
    Martin Fuchs
    Medicína pro praxi.2024; 21(1): 18.     CrossRef
  • Pilot Study on the Prevalence of Diamine Oxidase Gene Variants in Patients with Symptoms of Histamine Intolerance
    Adriana Duelo, Oriol Comas-Basté, Sònia Sánchez-Pérez, M. Teresa Veciana-Nogués, Eva Ruiz-Casares, M. Carmen Vidal-Carou, M. Luz Latorre-Moratalla
    Nutrients.2024; 16(8): 1142.     CrossRef
  • Histamine Intolerance: Symptoms, Diagnosis, and Beyond
    Christoph Jochum
    Nutrients.2024; 16(8): 1219.     CrossRef
  • Histamin İntoleransına Güncel Bakış
    Yeşim Öztekin
    İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi.2024; (22): 446.     CrossRef
  • A Novel Herbal Composition Alleviates Functional Constipation, Reduces Gastrointestinal Transit Time, and Improves Bowel Function in Adults: A Double-Blind, Randomized Clinical Study
    Gaurav Singh, Indresh Dixit, Douglas Kalman, Naga Tejaswi Gogineni
    Journal of the American Nutrition Association.2024; 43(6): 553.     CrossRef
  • Nutritional Implications of Mast Cell Diseases
    Cheryl Iny Harris, Bonnie Nasar, Celeste C. Finnerty
    Journal of the Academy of Nutrition and Dietetics.2024;[Epub]     CrossRef
  • The Factors Influencing the Concentration of Histamine in Jarred Baby Foods Containing Fish, Considering Evaluation of Daily Histamine Intake
    Marta Buczkowska, Anna Szczyrba, Dominika Szajnoga, Michał Górski, Jolanta Malinowska-Borowska, Joanna Domagalska, Piotr Rozentryt
    Journal of Food Protection.2024; 87(9): 100328.     CrossRef
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    Xin-Yi Liu, Yan Zhao, Ling-Ling Jin, Yue Pang, Bo Yu
    Journal of Asian Natural Products Research.2023; 25(9): 867.     CrossRef
  • Focus on histamine production during cheese manufacture and processing: A review
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    Food Chemistry.2023; 419: 136046.     CrossRef
  • Cumulative effect of AOC1 gene variants on symptoms and pathological conditions in adult women with fibromyalgia: a pilot study
    Gülşah Okutan, Teresa Perucho Alcalde, Eva Ruiz Casares, Bruno F. Penadés, Guerthy Melissa Sánchez Niño, Ana Terrén Lora, Sara López Oliva, Lorena Torrente Estríngana, Adriana Duelo, Ismael San Mauro Martín
    Frontiers in Genetics.2023;[Epub]     CrossRef
  • Food Fermentation Technology: Examples of application in Malaysian Foods
    Genevie Eleanor Ruby, Noor Azira Abdul Mutalib, Nurul Hanisah Juhari, Ungku Fatimah Ungku Zainal Abidin
    Food and Humanity.2023; 1: 32.     CrossRef
  • Histamine intolerance and irritable bowel syndrome
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    Profilakticheskaya meditsina.2023; 26(6): 130.     CrossRef
  • Functional Abdominal Pain Disorders in Children May Be Associated with Food Intolerance/Malabsorption
    Wolfgang J. Schnedl, Michael Schenk, Simon Michaelis, Dietmar Enko, Harald Mangge
    Children.2023; 10(9): 1444.     CrossRef
  • Resistant potato starch supplementation reduces serum histamine levels in healthy adults with links to attenuated intestinal permeability
    Jason R. Bush, Jun Han, Edward C. Deehan, Scott V. Harding, Madhura Maiya, Joshua Baisley, David Schibli, David R. Goodlett
    Journal of Functional Foods.2023; 108: 105740.     CrossRef
  • Placebo-Controlled Histamine Challenge Disproves Suspicion of Histamine Intolerance
    Rebekka Karolin Bent, Claudia Kugler, Valentina Faihs, Ulf Darsow, Tilo Biedermann, Knut Brockow
    The Journal of Allergy and Clinical Immunology: In Practice.2023; 11(12): 3724.     CrossRef
  • Exogenous Supplementation with DAO Enzyme in Women with Fibromyalgia: A Double-Blind Placebo-Controlled Clinical Trial
    Gülşah Okutan, Guerthy Melissa Sánchez Niño, Ana Terrén Lora, Sara López Oliva, Ismael San Mauro Martín
    Journal of Clinical Medicine.2023; 12(20): 6449.     CrossRef
  • Diet of the 21st-century person — food intolerances and elimination diets
    Ewa Gacoń
    Health Promotion & Physical Activity.2023; 23(2): 21.     CrossRef
  • Health concerns associated with biogenic amines in food and interaction with amine oxidase drugs
    Bruno M Dala-Paula, Flávia B Custódio, Maria BA Gloria
    Current Opinion in Food Science.2023; 54: 101090.     CrossRef
  • Myths and Facts about Food Intolerance: A Narrative Review
    Fabiana Zingone, Luisa Bertin, Daria Maniero, Michela Palo, Greta Lorenzon, Brigida Barberio, Carolina Ciacci, Edoardo Vincenzo Savarino
    Nutrients.2023; 15(23): 4969.     CrossRef
  • Diamine Oxidase Interactions with Anti-Inflammatory and Anti-Migraine Medicines in the Treatment of Migraine
    Yaiza Tobajas, Marc Alemany-Fornés, Iris Samarra, Jordi Romero-Giménez, Maria Tintoré, Antoni del Pino, Núria Canela, Josep M. del Bas, Nàdia Ortega-Olivé, Carlos de Lecea, Xavier Escoté
    Journal of Clinical Medicine.2023; 12(23): 7502.     CrossRef
  • Nachblutung bei Septorhinoplastik
    Olaf Michel
    HNO Nachrichten.2023; 53(6): 35.     CrossRef
  • Intolerancia alimentaria
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    Revista Alergia México.2023; 70(4): 265.     CrossRef
  • Diagnóstico diferencial en alergia alimentaria
    Liziane Nunes de Castilho Santos
    Revista Alergia México.2023; 70(4): 260.     CrossRef
  • Food allergy and hypersensitivity reactions in children and adults—A review
    Sandra G. Tedner, Anna Asarnoj, Helena Thulin, Marit Westman, Jon R. Konradsen, Caroline Nilsson
    Journal of Internal Medicine.2022; 291(3): 283.     CrossRef
  • Histamine Intolerance—A Kind of Pseudoallergic Reaction
    Ying Zhao, Xiaoyan Zhang, Hengxi Jin, Lu Chen, Jiang Ji, Zhongwei Zhang
    Biomolecules.2022; 12(3): 454.     CrossRef
  • Food intolerances and the small intestine
    Asfold I. Parfenov
    Terapevticheskii arkhiv.2022; 94(2): 153.     CrossRef
  • Basal Serum Diamine Oxidase Levels as a Biomarker of Histamine Intolerance: A Retrospective Cohort Study
    Valentina Cucca, Giuseppe A. Ramirez, Patrizia Pignatti, Chiara Asperti, Marco Russo, Emanuel Della-Torre, Daniela Breda, Samuele E. Burastero, Lorenzo Dagna, Mona-Rita Yacoub
    Nutrients.2022; 14(7): 1513.     CrossRef
  • Intestinal Dysbiosis in Patients with Histamine Intolerance
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    Nutrients.2022; 14(9): 1774.     CrossRef
  • Serum Diamine Oxidase Values, Indicating Histamine Intolerance, Influence Lactose Tolerance Breath Test Results
    Wolfgang J. Schnedl, Nathalie Meier-Allard, Simon Michaelis, Sonja Lackner, Dietmar Enko, Harald Mangge, Sandra J. Holasek
    Nutrients.2022; 14(10): 2026.     CrossRef
  • WITHDRAWN: Elevated histamine etiology model for most major vaccine associated adverse events including SARS-CoV-2 spike vaccines
    Darrell O. Ricke
    Medical Hypotheses.2022; : 110893.     CrossRef
  • Histamine intolerance (HIT)
    Joanna Matysiak
    Journal of Medical Science.2022; : e727.     CrossRef
  • The dietary treatment of histamine intolerance reduces the abundance of some histamine-secreting bacteria of the gut microbiota in histamine intolerant women. A pilot study
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    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Advances in the Clinical Application of Histamine and Diamine Oxidase (DAO) Activity: A Review
    Zhaowang Tan, Yingwei Ou, Wenwei Cai, Yueliang Zheng, Hengjie Li, Yunyun Mao, Shengang Zhou, Jianfeng Tu
    Catalysts.2022; 13(1): 48.     CrossRef
  • Improvement of digestive symptoms in fibromyalgia patients following a diet modification according to histamine release test – an observational study
    Jose Gomez-Arguelles, Oscar Caceres, Manuel Blanco, Ceferino Maestu, Francisco Martin
    Rheumatology.2022; 60(3): 209.     CrossRef
  • Considering histamine in functional gastrointestinal disorders
    Wolfgang J. Schnedl, Dietmar Enko
    Critical Reviews in Food Science and Nutrition.2021; 61(17): 2960.     CrossRef
  • Non-responsive celiac disease may coincide with additional food intolerance/malabsorption, including histamine intolerance
    Wolfgang J. Schnedl, Harald Mangge, Michael Schenk, Dietmar Enko
    Medical Hypotheses.2021; 146: 110404.     CrossRef
  • Histamine accumulation in dairy products: Microbial causes, techniques for the detection of histamine‐producing microbiota, and potential solutions
    Marta Moniente, Diego García‐Gonzalo, Ignacio Ontañón, Rafael Pagán, Laura Botello‐Morte
    Comprehensive Reviews in Food Science and Food Safety.2021; 20(2): 1481.     CrossRef
  • Histamine Intolerance Originates in the Gut
    Wolfgang J. Schnedl, Dietmar Enko
    Nutrients.2021; 13(4): 1262.     CrossRef
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    Nutrients.2021; 13(5): 1395.     CrossRef
  • Histamine Intolerance in Children: A Narrative Review
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    Nutrients.2021; 13(5): 1486.     CrossRef
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    Nutrients.2021; 13(5): 1638.     CrossRef
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    Nutrients.2021; 13(9): 3207.     CrossRef
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    Food Quality and Safety.2021;[Epub]     CrossRef
  • Comparing histamine intolerance and non-clonal mast cell activation syndrome
    Nevio Cimolai
    Intestinal Research.2020; 18(1): 134.     CrossRef
  • Lyophilised legume sprouts as a functional ingredient for diamine oxidase enzyme supplementation in histamine intolerance
    Oriol Comas-Basté, M. Luz Latorre-Moratalla, Judit Rabell-González, M. Teresa Veciana-Nogués, M. Carmen Vidal-Carou
    LWT.2020; 125: 109201.     CrossRef
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    Biomolecules.2020; 10(8): 1181.     CrossRef
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  • Interdisciplinary Significance of Food-Related Adverse Reactions in Adulthood
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    Scientific Reports.2020;[Epub]     CrossRef
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    Nutrients.2019; 11(7): 1684.     CrossRef
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Brief Communication
Miscellaneous
Fecal microbiota transplant via colonoscopy may be preferred due to intraprocedure findings
Janice M. Cho, Laura Pestana, Ryan Pardi, Darrell S. Pardi, Sahil Khanna
Intest Res 2019;17(3):434-437.   Published online May 31, 2019
DOI: https://doi.org/10.5217/ir.2019.00056
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Citations

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  • Retrospective subgroup analysis of fecal microbiota, live-jslm (REBYOTA®) administered by colonoscopy under enforcement discretion for the prevention of recurrent Clostridioides difficile infection
    Whitfield L. Knapple, David S. Yoho, Alexander Sheh, Joan Thul, Paul Feuerstadt
    Therapeutic Advances in Gastroenterology.2024;[Epub]     CrossRef
  • Non-alcoholic fatty liver disease and gut microbial dysbiosis- underlying mechanisms and gut microbiota mediated treatment strategies
    Muthukumaran Jayachandran, Shen Qu
    Reviews in Endocrine and Metabolic Disorders.2023; 24(6): 1189.     CrossRef
  • Efficacy of Fecal Microbiota Transplantation for Recurrent C. Difficile Infection in Inflammatory Bowel Disease
    Raseen Tariq, Molly B Disbrow, John K Dibaise, Robert Orenstein, Srishti Saha, Dipesh Solanky, Edward V Loftus, Darrell S Pardi, Sahil Khanna
    Inflammatory Bowel Diseases.2020; 26(9): 1415.     CrossRef
  • Faecal Microbiota Transplantation is Effective for the Initial Treatment of Clostridium difficile Infection: A Retrospective Clinical Review
    Niloufar Roshan, Annabel K. Clancy, Thomas J. Borody
    Infectious Diseases and Therapy.2020; 9(4): 935.     CrossRef
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A pulmonary nodule in a patient with Crohn’s disease
Akira Hokama, Shusaku Haranaga, Takanobu Sasaki, Hirofumi Matsumoto, Tetsuya Ohira, Atsushi Iraha, Tetsu Kinjo, Saifun Nahar, Jiro Fujita
Intest Res 2019;17(3):438-439.   Published online February 11, 2019
DOI: https://doi.org/10.5217/ir.2019.00010
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