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Volume 18(3); July 2020
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Editorials
Inflammatory bowel diseases
Tumor necrosis factor-α inhibitor use in patients with malignancy: is it safe?
Gyu Man Oh, Won Moon
Intest Res 2020;18(3):245-246.   Published online July 20, 2020
DOI: https://doi.org/10.5217/ir.2020.00061
PDFPubReaderePub

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  • Impact of Crohn’s Disease on the Survival of Patients with Small-Bowel Adenocarcinoma in Korea: A Bicenter Cohort Study
    Kyuwon Kim, Kookhwan Choi, Sung Wook Hwang, Jong Pil Im, Byong Duk Ye, Joo Sung Kim, Kyu Joo Park, Suk-Kyun Yang, Seong-Joon Koh, Sang Hyoung Park
    Gut and Liver.2023; 17(4): 581.     CrossRef
  • 4,148 View
  • 104 Download
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Education levels and survival in colorectal cancer: is there really an obvious association?
Bruna Valiati, Rodrigo Oliva Perez, Paulo Gustavo Kotze
Intest Res 2020;18(3):247-248.   Published online July 20, 2020
DOI: https://doi.org/10.5217/ir.2020.00064
PDFPubReaderePub

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  • Correlations between Demographic, Clinical, and Paraclinical Variables and Outcomes in Patients with KRAS-Mutant or KRAS Wild-Type Metastatic Colorectal Cancer—A Retrospective Study from a Tertiary-Level Center in Romania
    Edvina Elena Pîrvu, Emilia Severin, Raluca Ileana Pătru, Irina Niță, Stefania Andreea Toma, Roxana Rodica Macarie, Cristina Elena Cocioabă, Ioana Florescu, Simona Coniac
    Diagnostics.2023; 13(18): 2930.     CrossRef
  • 4,100 View
  • 71 Download
  • 2 Web of Science
  • 1 Crossref
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Reviews
Inflammatory bowel diseases
Pathogenesis and clinical perspectives of extraintestinal manifestations in inflammatory bowel diseases
Jung Min Kim, Jae Hee Cheon
Intest Res 2020;18(3):249-264.   Published online April 18, 2020
DOI: https://doi.org/10.5217/ir.2019.00128
AbstractAbstract PDFPubReaderePub
A considerable number of patients with inflammatory bowel disease (IBD) experience extraintestinal manifestations (EIMs), which can present either before or after IBD diagnosis. Unraveling the pathogenic pathways of EIMs in IBD is challenging because of the lack of reliable criteria for diagnosis and difficulty in distinguishing EIMs from external pathologies caused by drugs or other etiologies. Optimizing treatment can also be difficult. Early diagnosis and management of EIM revolve around multidisciplinary teams, and they should have the resources necessary to make and implement appropriate decisions. In addition, specialists of the affected organs should be trained in IBD treatment. Furthermore, patient awareness regarding the extraintestinal symptoms of IBD is of paramount importance for improving patient understanding of disease and health outcomes. Herein, we review the pathogenesis and clinical perspectives of EIMs in IBD.

Citations

Citations to this article as recorded by  
  • Pomegranate seed oil mitigates liver and kidney damage in an experimental colitis model: Modulation of NF-κB activation and apoptosis
    Açelya Gül Koyuncu, Alev Cumbul, Elvan Yilmaz Akyüz, Müge Kopuz Alvarez Noval
    Prostaglandins & Other Lipid Mediators.2024; 171: 106804.     CrossRef
  • Screening of silent inflammatory bowel disease in seronegative spondyloarthritis patients: Fecal calprotectin, ileo-colonoscopy and histopathology assessment
    Shaimaa Badran, Andrew Saweres, Hadeel GamalEldeen, Mohamed B. Hashem, Dalia Abdel-kareem, Fatma H. Abdelraouf, Wafaa Gaber, Tamer Elbaz
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  • Effect of ustekinumab on extraintestinal manifestations in patients with Crohn’s disease or ulcerative colitis
    D. I. Abdulganieva, D. D. Mukhametova
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  • Extraintestinal Manifestations in Inflammatory Bowel Disease: From Pathophysiology to Treatment
    Ilaria Faggiani, Jacopo Fanizza, Ferdinando D’Amico, Mariangela Allocca, Alessandra Zilli, Tommaso Lorenzo Parigi, Alberto Barchi, Silvio Danese, Federica Furfaro
    Biomedicines.2024; 12(8): 1839.     CrossRef
  • Long‐term clinical outcomes of intestinal Behçet's disease: A 30‐year cohort study at a tertiary hospital in South Korea
    Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Hee Cheon
    Journal of Gastroenterology and Hepatology.2023; 38(3): 386.     CrossRef
  • Risks of colorectal cancer and biliary cancer according to accompanied primary sclerosing cholangitis in Korean patients with ulcerative colitis: a nationwide population-based study
    Eun Hye Oh, Ye-Jee Kim, Minju Kim, Seung Ha Park, Tae Oh Kim, Sang Hyoung Park
    Intestinal Research.2023; 21(2): 252.     CrossRef
  • The Oral-Gut Axis: Periodontal Diseases and Gastrointestinal Disorders
    Gretchen A Lam, Hala Albarrak, Cassidy J McColl, Alaina Pizarro, Harsha Sanaka, Adrian Gomez-Nguyen, Fabio Cominelli, Andre Paes Batista da Silva
    Inflammatory Bowel Diseases.2023; 29(7): 1153.     CrossRef
  • Risk Factors for Surgery in Patients with Intestinal Behçet’s Disease During Anti-Tumor Necrosis Factor-Alpha Therapy
    So Jung Han, Eun Ae Kang, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
    Yonsei Medical Journal.2023; 64(2): 111.     CrossRef
  • Are the risks of colorectal cancer and biliary cancer really increased if patients with ulcerative colitis have primary sclerosing cholangitis?
    Jung Wook Lee, Won Moon
    Intestinal Research.2023; 21(2): 171.     CrossRef
  • The Relationship Between Rosacea and Inflammatory Bowel Disease: A Systematic Review and Meta-analysis
    Yu Kyung Jun, Da-Ae Yu, Yoo Min Han, Soo Ran Lee, Seong-Joon Koh, Hyunsun Park
    Dermatology and Therapy.2023; 13(7): 1465.     CrossRef
  • Treatment of primary sclerosing cholangitis combined with inflammatory bowel disease
    You Sun Kim, Edward H. Hurley, Yoojeong Park, Sungjin Ko
    Intestinal Research.2023; 21(4): 420.     CrossRef
  • Novel Histone Deacetylase 6 Inhibitor Confers Anti-inflammatory Effects and Enhances Gut Barrier Function
    Jae-Young Lee, Hyun Woo Ma, Ji Hyung Kim, I Seul Park, Mijeong Son, Keun Ho Ryu, Jieun Shin, Seung Won Kim, Jae Hee Cheon
    Gut and Liver.2023; 17(5): 766.     CrossRef
  • Regional variations in the prevalence of primary sclerosing cholangitis associated with inflammatory bowel disease
    Kwang Woo Kim, Hyoun Woo Kang
    Intestinal Research.2023; 21(4): 413.     CrossRef
  • Downregulation of Heat Shock Protein 72 Contributes to Fibrostenosis in Crohn’s Disease
    Seung Won Kim, Jae-Young Lee, Han Cheol Lee, Jae Bum Ahn, Ji Hyung Kim, I Seul Park, Jae Hee Cheon, Duk Hwan Kim
    Gut and Liver.2023; 17(6): 905.     CrossRef
  • Effectiveness and safety of adalimumab in patients with intestinal Behçet’s disease: a real-world prospective observational study in South Korea
    Jongwook Yu, Sung Jae Shin, Yune-Jung Park, Hyung Wook Kim, Bo-In Lee, Byong Duk Ye, Geun-Tae Kim, Sung Kook Kim, Joo Sung Kim, Young-Ho Kim, Seonjeong Jeong, Jae Hee Cheon
    BMC Gastroenterology.2023;[Epub]     CrossRef
  • Fermented rice bran supplementation attenuates chronic colitis-associated extraintestinal manifestations in female C57BL/6N mice
    Jahidul Islam, Afifah Zahra Agista, Kouichi Watanabe, Tomonori Nochi, Hisashi Aso, Yusuke Ohsaki, Takuya Koseki, Michio Komai, Hitoshi Shirakawa
    The Journal of Nutritional Biochemistry.2022; 99: 108855.     CrossRef
  • Functional Gastrointestinal Disorders in Patients with Inflammatory Bowel Disease
    Kyeong Ok Kim
    The Korean Journal of Gastroenterology.2022; 79(1): 4.     CrossRef
  • Is primary sclerosing cholangitis with inflammatory bowel disease different between patients in the East and West?
    Yong Eun Park
    Intestinal Research.2022; 20(2): 157.     CrossRef
  • A Review of Extraintestinal Manifestations & Medication-Induced Myocarditis and Pericarditis in Pediatric Inflammatory Bowel Disease
    Kevin Cesa, Catherine Cunningham, Tyler Harris, Whitney Sunseri
    Cureus.2022;[Epub]     CrossRef
  • Venous Thromboembolism Risk in Asian Patients with Inflammatory Bowel Disease: A Population-Based Nationwide Inception Cohort Study
    Su Young Kim, Yeon Seo Cho, Hyun-Soo Kim, Jung Kuk Lee, Hee Man Kim, Hong Jun Park, Hyunil Kim, Jihoon Kim, Dae Ryong Kang
    Gut and Liver.2022; 16(4): 555.     CrossRef
  • Medication Adherence in Korean Patients with Inflammatory Bowel Disease and Its Associated Factors
    Kyunghwan Oh, Eun Ja Kwon, Jeong Hye Kim, Kyuwon Kim, Jae Yong Lee, Hee Seung Hong, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Jeong Yun Park, Sang Hyoung Park
    The Ewha Medical Journal.2022; 45(2): 35.     CrossRef
  • Inflammatory bowel disease in Korea: epidemiology and pathophysiology
    Jung Won Lee, Chang Soo Eun
    The Korean Journal of Internal Medicine.2022; 37(5): 885.     CrossRef
  • Korean Association for the Study of Intestinal Diseases guidance for clinical practice of adult inflammatory bowel disease during the coronavirus disease 2019 pandemic: expert consensus statements
    Yong Eun Park, Yoo Jin Lee, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seong-Eun Kim, Seung-Jae Myung
    Intestinal Research.2022; 20(4): 431.     CrossRef
  • A Review of Ophthalmic Complications in Inflammatory Bowel Diseases
    Wiktoria Pytrus, Katarzyna Akutko, Tomasz Pytrus, Anna Turno-Kręcicka
    Journal of Clinical Medicine.2022; 11(24): 7457.     CrossRef
  • Atopic dermatitis does not increase the risk of inflammatory bowel disease: A nationwide cohort study
    Yu‐Ching Weng, Chao‐Kuei Juan, Hsiu J. Ho, Yi‐Ling Chang, Chun‐Ying Wu, Yi‐Ju Chen
    The Journal of Dermatology.2021; 48(2): 168.     CrossRef
  • Subclinical sacroiliitis detected by abdominopelvic computed tomography in Korean patients with Crohn’s disease
    You-Jung Ha, Hyo Jin Kim, Eugene Lee, Ji Hye Park, Young Soo Park, Yun Jong Lee, Yusuhn Kang, Hyuk Yoon
    The Korean Journal of Internal Medicine.2021; 36(4): 868.     CrossRef
  • Proteomic analysis-based discovery of a novel biomarker that differentiates intestinal Behçet’s disease from Crohn’s disease
    Jihye Park, Daeun Jeong, Youn Wook Chung, Seunghan Han, Da Hye Kim, Jongwook Yu, Jae Hee Cheon, Ji-Hwan Ryu
    Scientific Reports.2021;[Epub]     CrossRef
  • Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management
    Gerhard Rogler, Abha Singh, Arthur Kavanaugh, David T. Rubin
    Gastroenterology.2021; 161(4): 1118.     CrossRef
  • Pancreatic Associated Manifestations in Pediatric Inflammatory Bowel Diseases
    Ugo Cucinotta, Claudio Romano, Valeria Dipasquale
    Genes.2021; 12(9): 1372.     CrossRef
  • KASID Guidance for Clinical Practice Management of Adult Inflammatory Bowel Disease during the COVID-19 Pandemic: Expert Consensus Statement
    Yong Eun Park, Yoo Jin Lee, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seong-Eun Kim, Seung-Jae Myung
    The Korean Journal of Gastroenterology.2021; 78(2): 105.     CrossRef
  • Epidemiology and diagnosis of inflammatory bowel diseases
    Kang-Moon Lee
    Journal of the Korean Medical Association.2021; 64(9): 579.     CrossRef
  • Current status of inflammatory bowel diseases in Korea
    Suk-Kyun Yang
    Journal of the Korean Medical Association.2021; 64(9): 572.     CrossRef
  • A review of ophthalmic manifestations of inflammatory bowel disease and associated treatments
    Priya Janardhana, Saad Al-Kadhi
    Current Opinion in Ophthalmology.2021; 32(6): 549.     CrossRef
  • Etiopathogenic and Clinical Aspects in Inflammatory Bowel Disease – Literature Review
    Petronela Nicoleta Seritean Isac, Diana Popescu, Tudor Marcel Genes, Minerva Codruta Badescu, Ioana Irina Rezus, Nicoleta Dima, Ana Roxana Rusu Ganceanu, Elena Rezus, Ciprian Rezus
    Journal of Interdisciplinary Medicine.2021; 6(3): 132.     CrossRef
  • Crohn’s disease at radiological imaging: focus on techniques and intestinal tract
    Giuseppe Cicero, Silvio Mazziotti
    Intestinal Research.2021; 19(4): 365.     CrossRef
  • Anti-inflammatory properties of Escherichia coli Nissle 1917 in a murine colitis model
    Jihye Park, Da Hye Kim, Soochan Kim, Hyun Woo Ma, I Seul Park, Mijeong Son, Ji Hyung Kim, Yoojin Shin, Seung Won Kim, Jae Hee Cheon
    Intestinal Research.2021; 19(4): 478.     CrossRef
  • Ficus pandurata Hance Inhibits Ulcerative Colitis and Colitis‐Associated Secondary Liver Damage of Mice by Enhancing Antioxidation Activity
    Weibo Dai, Xinyi Zhan, Weijie Peng, Xin Liu, Weiwen Peng, Quanxi Mei, Xianjing Hu, Kai Wang
    Oxidative Medicine and Cellular Longevity.2021;[Epub]     CrossRef
  • Liver-side of inflammatory bowel diseases: Hepatobiliary and drug-induced disorders
    Stefano Mazza, Sara Soro, Maria Chiara Verga, Biagio Elvo, Francesca Ferretti, Fabrizio Cereatti, Andrea Drago, Roberto Grassia
    World Journal of Hepatology.2021; 13(12): 1828.     CrossRef
  • Temporal Relationship of Extraintestinal Manifestations in Inflammatory Bowel Disease
    Istvan Fedor, Eva Zold, Zsolt Barta
    Journal of Clinical Medicine.2021; 10(24): 5984.     CrossRef
  • 14,621 View
  • 439 Download
  • 40 Web of Science
  • 40 Crossref
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Inflammatory bowel diseases
Capsule endoscopy in inflammatory bowel disease: when and how
Ida Hilmi, Taku Kobayashi
Intest Res 2020;18(3):265-274.   Published online July 7, 2020
DOI: https://doi.org/10.5217/ir.2019.09165
AbstractAbstract PDFPubReaderePub
Capsule endoscopy (CE) is emerging as an important investigation in inflammatory bowel disease (IBD); common types include the standard small bowel CE and colon CE. More recently, the pan-enteric CE was developed to assess the large and small bowel in patients with Crohn’s disease (CD). Emerging indications include noninvasive assessment for mucosal healing (both in the small bowel and the colon) and detection of postoperative recurrence in patients with CD. Given the increasing adoption, several CE scoring systems have been specifically developed for IBD. The greatest concern with performing CE, particularly in CD, is capsule retention, but this can be overcome by performing cross-sectional imaging such as magnetic resonance enterography and using patency capsules before performing the procedure. The development of software for automated detection of mucosal abnormalities typically seen in IBD may further increase its adoption.

Citations

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    Virginia Solitano, Ferdinando D’Amico, Mariangela Allocca, Gionata Fiorino, Alessandra Zilli, Laura Loy, Daniela Gilardi, Simona Radice, Carmen Correale, Silvio Danese, Laurent Peyrin-Biroulet, Federica Furfaro
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  • Addition of castor oil as a booster in colon capsule regimens significantly improves completion rates and polyp detection
    Serhiy Semenov, Mohd Syafiq Ismail, Fintan O'Hara, Sandeep Sihag, Barbara Ryan, Anthony O'Connor, Sarah O'Donnell, Deirdre McNamara
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  • 6,948 View
  • 250 Download
  • 12 Web of Science
  • 14 Crossref
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Inflammatory bowel diseases
NUDT15 gene variants and thiopurine-induced leukopenia in patients with inflammatory bowel disease
Katsuyoshi Matsuoka
Intest Res 2020;18(3):275-281.   Published online June 3, 2020
DOI: https://doi.org/10.5217/ir.2020.00002
AbstractAbstract PDFPubReaderePub
Thiopurine has been used to maintain remission and to reduce antidrug antibody formation in monoclonal antibody therapy in patients with inflammatory bowel disease (IBD). The use of thiopurine is limited by side effects such as leukopenia. Thiopurine S-methyltransferase (TPMT) variants are associated with thiopurine-induced leukopenia in Westerners, but the frequency of the risk alleles is low in Asians. Recently, a variant in the nudix hydrolase 15 (NUDT15) gene (R139C, c.415C > T) was reported to be associated with early severe leukopenia in Asians. NUDT15 is an enzyme that converts 6-thio-(deoxy)guanosine triphosphate (6-T(d)GTP) to 6-thio-(deoxy)guanosine monophosphate (6-T(d)GMTP). The R139C variant impairs the stability of the protein and increases incorporation of 6-TGTP and 6-TdGTP into RNA and DNA, respectively, resulting in leukopenia. The frequency of C/C, C/T, and T/T are approximately 80%, 20%, and 1%, respectively in East Asians. Early leukopenia occurred in less than 3% of patients with C/C and in around 20% of those with C/T, whereas it occurred in almost all patients with T/T. Patients homozygous for this variant also develop severe hair loss. The measurement of NUDT15 R139C can increase the safety of thiopurine dramatically and is a successful example of personalized medicine in the field of IBD.

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    Shenjia Huang, Yicong Bian, Chenrong Huang, Liyan Miao
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  • Updates on conventional therapies for inflammatory bowel diseases: 5-aminosalicylates, corticosteroids, immunomodulators, and anti-TNF-α
    Jihye Park, Jae Hee Cheon
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    Chuang‐Wei Wang, Min‐Hui Chi, Tsen‐Fang Tsai, Kuang‐Hui Yu, Hsiao‐Wen Kao, Hsiang‐Cheng Chen, Chun‐Bing Chen, Chun‐Wei Lu, Wei‐Ti Chen, Ya‐Ching Chang, Chih‐Jung Chang, Yun‐Ting Chang, Yeong‐Jian Jan Wu, Chee‐Jen Chang, Yu Huei Huang, Chau‐Yee Ng, Po‐Wei
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  • Monotherapy with thiopurines in stricturing Crohn’s disease: A real-life experience from low- and middle-income countries
    Bhaskar Kante, Sudheer Kumar Vuyyuru, Saurabh Kedia, Pabitra Sahu, Peeyush Kumar, Mukesh Kumar Ranjan, Shubi Virmani, Raju Sharma, Kumble Seetharama Madhusudhan, Rajesh Panwar, Prasenjit Das, Govind Makharia, Vineet Ahuja
    Indian Journal of Gastroenterology.2022; 41(4): 343.     CrossRef
  • Personalized medicine to implementation science: Thiopurines set for the leap
    Vishal Sharma, Saurabh Kedia, Vineet Ahuja
    JGH Open.2022; 6(10): 651.     CrossRef
  • Natural history of inflammatory bowel disease: a comparison between the East and the West
    Eun Mi Song, Suk-Kyun Yang
    Intestinal Research.2022; 20(4): 418.     CrossRef
  • Prevalence of polymorphisms in thiopurine metabolism and association with adverse outcomes: a South Asian region-specific systematic review and meta-analysis
    Anuraag Jena, Daya Krishna Jha, Praveen Kumar-M, Kripa Shanker Kasudhan, Ankit Kumar, Dhruv Sarwal, Shubhra Mishra, Anupam Kumar Singh, Prateek Bhatia, Amol Patil, Vishal Sharma
    Expert Review of Clinical Pharmacology.2021; 14(4): 491.     CrossRef
  • Clinical characteristics of ulcerative colitis in elderly patients
    Mingming Zhu, Zhihua Ran
    JGH Open.2021; 5(8): 849.     CrossRef
  • TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India
    Narinder Grover, Prateek Bhatia, Antriksh Kumar, Minu Singh, Deepesh Lad, Harshal S. Mandavdhare, Jayanta Samanta, Kaushal K. Prasad, Usha Dutta, Vishal Sharma
    BMC Gastroenterology.2021;[Epub]     CrossRef
  • Current status of inflammatory bowel diseases in Korea
    Suk-Kyun Yang
    Journal of the Korean Medical Association.2021; 64(9): 572.     CrossRef
  • Treatment of inflammatory bowel diseases: focusing on 5-aminosalicylates and immunomodulators
    You Sun Kim
    Journal of the Korean Medical Association.2021; 64(9): 596.     CrossRef
  • Pharmacogenetics-based personalized treatment in patients with inflammatory bowel disease: A review
    Ji Young Chang, Jae Hee Cheon
    Precision and Future Medicine.2021; 5(4): 151.     CrossRef
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Original Articles
Inflammatory bowel diseases
Safety of tumor necrosis factor inhibitor use in patients with concomitant malignancy
Hiep Phan, Rick A. Weideman, Daisha J. Cipher, Linda A. Feagins
Intest Res 2020;18(3):282-288.   Published online April 7, 2020
DOI: https://doi.org/10.5217/ir.2019.09140
AbstractAbstract PDFPubReaderePub
Background/Aims
Safety for tumor necrosis factor inhibitors (TNFi) in cancer has been focused on risk of incident malignancies, but studies on prognostic effects have been scarce. We determined survival and recurrence rates at 1, 2, and 5 years after cancer diagnosis in patients with and without concurrent TNFi use.
Methods
Chart reviews were performed between 1996 and 2015 at the VA North Texas Healthcare System. Cases were patients with inflammatory disease, concomitant malignancy, and TNFi use while controls were patients with inflammatory disease, concomitant malignancy but no TNFi use. Cases and controls were matched for type of malignancy. Analysis was performed with log-rank tests on Kaplan-Meier curves.
Results
Thirty-six cases and 72 controls were identified. For cases, survival at 1, 2, and 5 years were 32 (89%), 31 (86%), and 29 (81%) compared to 63 (90%), 61 (87%), and 51 (73%) for the control group (P=0.985). For cases, recurrence rates at 1, 2, and 5 years were 3 (8%), 5 (14%), and 6 (17%) compared to 2 (3%), 5 (7%), and 7 (10%) for the control group (P=0.158).
Conclusions
Our findings suggest TNFi may be safely used in select inflammatory disease patients with concurrent cancer if therapy is needed for proper disease control. However, case-by-case consideration in conjunction with an oncologist is recommended while considering the apparent safety of TNFi for patients suffering from active inflammatory diseases despite having a concomitant malignancy.

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  • Risk of Cancer Recurrence in Patients With Immune-Mediated Diseases With Use of Immunosuppressive Therapies: An Updated Systematic Review and Meta-Analysis
    Akshita Gupta, Laurent Peyrin-Biroulet, Ashwin N. Ananthakrishnan
    Clinical Gastroenterology and Hepatology.2024; 22(3): 499.     CrossRef
  • Survival in patients with rheumatoid arthritis and early breast cancer treated with tumor necrosis factor inhibitors
    Juan I. Ruiz, Xiudong Lei, Wu Chi-Fang, Sharon H. Giordano, Hui Zhao, Suja S. Rajan, Heather Lin, Maria E. Suarez-Almazor
    Breast Cancer.2024;[Epub]     CrossRef
  • Anti-tumor necrosis factor-alpha monoclonal antibody suppresses colorectal cancer growth in an orthotopic transplant mouse model
    Takeshi Takasago, Ryohei Hayashi, Yoshitaka Ueno, Misa Ariyoshi, Kana Onishi, Ken Yamashita, Yuichi Hiyama, Hidehiko Takigawa, Ryo Yuge, Yuji Urabe, Shiro Oka, Yasuhiko Kitadai, Shinji Tanaka, Kenji Fujiwara
    PLOS ONE.2023; 18(3): e0283822.     CrossRef
  • Dermatofibrosarcoma Protuberans (DFSP) with Fibrosarcomatous Changes in a Patient with Crohn’s Disease Treated with Anti-TNF (Adalimumab)
    Ivo Klarin, Yoshihiro Moriwaki
    Case Reports in Gastrointestinal Medicine.2023; 2023: 1.     CrossRef
  • Use of Disease-modifying Antirheumatic Drugs After Cancer Diagnosis in Rheumatoid Arthritis Patients
    Young Bin Joo, Seung Min Jung, Yune-Jung Park, Ki-Jo Kim, Kyung-Su Park
    Journal of Rheumatic Diseases.2022; 29(3): 162.     CrossRef
  • Updates on conventional therapies for inflammatory bowel diseases: 5-aminosalicylates, corticosteroids, immunomodulators, and anti-TNF-α
    Jihye Park, Jae Hee Cheon
    The Korean Journal of Internal Medicine.2022; 37(5): 895.     CrossRef
  • Twenty Years of Targeted and Biologic Immunomodulatory Drugs
    Julia Berman, Yarden Yavne, Yonatan Edel, Ori Elkayam, Victoria Furer, Daniel Shepshelovich
    Mayo Clinic Proceedings.2022; 97(8): 1512.     CrossRef
  • Impact of rheumatoid arthritis and biologic and targeted synthetic disease modifying antirheumatic agents on cancer risk and recurrence
    Namrata Singh, Christopher I. Li
    Current Opinion in Rheumatology.2021; 33(3): 292.     CrossRef
  • Can Anti-Tumor Necrosis Factor Agents Be Discontinued in Patients with Inflammatory Bowel Disease?
    Jihye Park, Jae Hee Cheon
    Gut and Liver.2021; 15(5): 641.     CrossRef
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Inflammatory bowel diseases
Presentation and outcomes among inflammatory bowel disease patients with concurrent pneumatosis intestinalis: a case series and systematic review
Youran Gao, Meka Uffenheimer, Michael Ashamallah, Gregory Grimaldi, Arun Swaminath, Keith Sultan
Intest Res 2020;18(3):289-296.   Published online November 4, 2019
DOI: https://doi.org/10.5217/ir.2019.00073
AbstractAbstract PDFPubReaderePub
Background/Aims
Inflammatory bowel disease (IBD) involves chronic inflammation of the colon with ulcerative colitis (UC), and the colon and/or small intestine with Crohn’s disease (CD). Pneumatosis intestinalis (PI), characterized by compromise of the intestinal wall with gas-filled cysts, has rarely been reported with IBD. The presentation, best management and outcomes of PI with IBD are poorly defined.
Methods
We conducted a search for PI in all abdominal computed tomography (CT) reports at 2 large tertiary care hospitals from January 1, 2010 to December 31, 2017, cross referenced to ICD codes for IBD. CT and chart review was performed to confirm PI and IBD respectively. A systematic review excluding case reports was performed for PI with IBD for comparison.
Results
Of 5,990 patients with a CT abdomen report mentioning PI, we identified 11 cases of PI with IBD, 4 UC, 6 CD, and 1 indeterminate colitis. PI was limited to the small bowel in 5 patients, the right colon in 5, and small bowel and colonic in 1. All 3 mortalities had CD, small intestinal PI and portal/mesenteric venous gas. The systematic literature search identified 9 articles describing 58 patients with IBD and PI. These cases were mostly included in larger cohorts of PI patients without extractable data on presentation or outcomes in the IBD subpopulation.
Conclusions
Ours appears to be the first reporting of presentations and outcomes, outside of case reports, for those with PI and IBD. The high mortality for those with CD and PI of the small bowel appears to define a group requiring more than supportive medical care.

Citations

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  • MR Enterography in Ulcerative Colitis: Beyond Endoscopy
    Amir Reza Radmard, Mehrnam Amouei, Ala Torabi, Ali Reza Sima, Hiva Saffar, Amine Geahchan, Amir H. Davarpanah, Bachir Taouli
    RadioGraphics.2024;[Epub]     CrossRef
  • Plaque-like Mucosal Change in Pneumatosis Intestinalis with Ulcerative Colitis
    Atsushi Ikehata, Machi Kiyohara, Sadahide Ono, Takashi Kajiwara
    Internal Medicine.2024;[Epub]     CrossRef
  • The Challenge of Pneumatosis Intestinalis: A Contemporary Systematic Review
    Gennaro Perrone, Mario Giuffrida, Valentina Donato, Gabriele Luciano Petracca, Giorgio Rossi, Giacomo Franzini, Sara Cecconi, Alfredo Annicchiarico, Elena Bonati, Fausto Catena
    Journal of Personalized Medicine.2024; 14(2): 167.     CrossRef
  • Pneumatosis Intestinalis Manifesting as an Atypical Presentation of Crohn’s Disease
    Charles Vallejo, Yousra Gheit, Talwinder K Nagi, Zoilo K Suarez, Muhammad Haider, Touqir Zahra
    Cureus.2024;[Epub]     CrossRef
  • The spectrum of pneumatosis intestinalis in the adult. A surgical dilemma
    Giuseppe Tropeano, Marta Di Grezia, Caterina Puccioni, Valentina Bianchi, Gilda Pepe, Valeria Fico, Gaia Altieri, Giuseppe Brisinda
    World Journal of Gastrointestinal Surgery.2023; 15(4): 553.     CrossRef
  • Neumoperitoneo secundario a neumatosis intestinal masiva: un reporte de caso
    David Charry-Borrero, Yesica Ascanio-Quintero, Juan Rodríguez-Valenzuela, Faure Yezid Rodríguez-Velásquez, Juan Felipe Coronado-Sarmiento, Eduardo Tuta-Quintero
    Revista Colombiana de Cirugía.2023;[Epub]     CrossRef
  • Idiopathic asymptomatic pneumoperitoneum in a patient with ureteric calculus and Crohn’s disease
    Gitte Grunnet Raabe, Benedicte Schelde-Olesen, Thomas Bjørsum-Meyer
    Journal of Surgical Case Reports.2022;[Epub]     CrossRef
  • Pneumatosis Intestinalis Induced by Anticancer Treatment: A Systematic Review
    Gianluca Gazzaniga, Federica Villa, Federica Tosi, Elio Gregory Pizzutilo, Stefano Colla, Stefano D’Onghia, Giusy Di Sanza, Giulia Fornasier, Michele Gringeri, Maria Victoria Lucatelli, Giulia Mosini, Arianna Pani, Salvatore Siena, Francesco Scaglione, An
    Cancers.2022; 14(7): 1666.     CrossRef
  • Pneumatosis Intestinalis Induced by Alpha-Glucosidase Inhibitors in Patients with Diabetes Mellitus
    Blake J. McKinley, Mariangela Santiago, Christi Pak, Nataly Nguyen, Qing Zhong
    Journal of Clinical Medicine.2022; 11(19): 5918.     CrossRef
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Inflammatory bowel diseases
Hypermethylated promoters of tumor suppressor genes were identified in Crohn’s disease patients
Tae-Oh Kim, Yu Kyeong Han, Joo Mi Yi
Intest Res 2020;18(3):297-305.   Published online February 7, 2020
DOI: https://doi.org/10.5217/ir.2019.00105
AbstractAbstract PDFPubReaderePub
Background/Aims
Overwhelming evidence suggests that inflammatory bowel disease (IBD) is caused by a complicated interplay between the multiple genes and abnormal epigenetic regulation in response to environmental factors. It is becoming apparent that epigenetic factors are significantly associated with the development of the disease. DNA methylation remains the most studied epigenetic modification, and hypermethylation of gene promoters is associated with gene silencing.
Methods
DNA methylation alterations may contribute to the many complex diseases development by regulating the interplay between external and internal environmental factors and gene transcriptional expression. In this study, we used 15 tumor suppressor genes (TSGs), originally identified in colon cancer, to detect promoter methylation in patients with Crohn’s disease (CD). Methylation specific polymerase chain reaction and bisulfite sequencing analyses were performed to assess methylation level of TSGs in CD patients.
Results
We found 6 TSGs (sFRP1, sFRP2, sFRP5, TFPI2, Sox17, and GATA4) are robustly hypermethylated in CD patient samples. Bisulfite sequencing analysis confirmed the methylation levels of the sFRP1, sFRP2, sFRP5, TFPI2, Sox17, and GATA4 promoters in the representative CD patient samples.
Conclusions
In this study, the promoter hypermethylation of the TSGs observed indicates that CD exhibits specific DNA methylation signatures with potential clinical applications for the noninvasive diagnosis of IBD and the prognosis for patients with IBD.

Citations

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  • Effects of DNA methylation and its application in inflammatory bowel disease (Review)
    Francis Akanyibah, Yi Zhu, Aijun Wan, Dickson Ocansey, Yuxuan Xia, An-Ning Fang, Fei Mao
    International Journal of Molecular Medicine.2024;[Epub]     CrossRef
  • Transcriptomic Module Discovery of Diarrhea-Predominant Irritable Bowel Syndrome: A Causal Network Inference Approach
    Davide Guido, Fatima Maqoud, Michelangelo Aloisio, Domenica Mallardi, Blendi Ura, Nicolò Gualandi, Massimiliano Cocca, Francesco Russo
    International Journal of Molecular Sciences.2024; 25(17): 9322.     CrossRef
  • From Crypts to Cancer: A Holistic Perspective on Colorectal Carcinogenesis and Therapeutic Strategies
    Ehsan Gharib, Gilles A. Robichaud
    International Journal of Molecular Sciences.2024; 25(17): 9463.     CrossRef
  • Epigenotoxicity: a danger to the future life
    Farzaneh Kefayati, Atoosa Karimi Babaahmadi, Taraneh Mousavi, Mahshid Hodjat, Mohammad Abdollahi
    Journal of Environmental Science and Health, Part A.2023; 58(4): 382.     CrossRef
  • Evaluating the Clinical Performance of a Dual-Target Stool DNA Test for Colorectal Cancer Detection
    Zhongxin Wang, Jian Shang, Guannan Zhang, Lingjun Kong, Feng Zhang, Ye Guo, Yaling Dou, Jun Lin
    The Journal of Molecular Diagnostics.2022; 24(2): 131.     CrossRef
  • Lipocalin 2 potentially contributes to tumorigenesis from colitis via IL-6/STAT3/NF-κB signaling pathway
    Se Lim Kim, Min Woo Shin, Seung Young Seo, Sang Wook Kim
    Bioscience Reports.2022;[Epub]     CrossRef
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    Su Hyun Park, Sang Hyoung Park
    Journal of Gastroenterology and Hepatology.2022; 37(8): 1434.     CrossRef
  • Landscape of sialylation patterns identify biomarkers for diagnosis and prediction of response to anti-TNF therapy in crohn’s disease
    Chenglin Ye, Sizhe Zhu, Yuan Gao, Yabing Huang
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • The role of epigenetic modifications for the pathogenesis of Crohn's disease
    M. Hornschuh, E. Wirthgen, M. Wolfien, K. P. Singh, O. Wolkenhauer, J. Däbritz
    Clinical Epigenetics.2021;[Epub]     CrossRef
  • SFRP5 inhibits melanin synthesis of melanocytes in vitiligo by suppressing the Wnt/β-catenin signaling
    Dao-Pei Zou, Yang-Mei Chen, Ling-Zhao Zhang, Xiao-Hui Yuan, Yu-Jie Zhang, Adelina Inggawati, Pham Thi Kieu Nguyet, Tian-Wen Gao, Jin Chen
    Genes & Diseases.2021; 8(5): 677.     CrossRef
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Inflammatory bowel diseases
Concordance between tuberculin skin test and interferon-gamma release assay for latent tuberculosis screening in inflammatory bowel disease
Saad Alrajhi, Pascale Germain, Myriam Martel, Peter Lakatos, Talat Bessissow, Talal Al-Taweel, Waqqas Afif
Intest Res 2020;18(3):306-314.   Published online March 20, 2020
DOI: https://doi.org/10.5217/ir.2019.00116
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background/Aims
Latent tuberculosis screening is mandatory prior to initiating anti-tumor necrosis factor (anti-TNF) medications. Guidelines recommend interferon-gamma release assays (IGRA) as first line screening method for the general population. Studies provided conflicting evidence on IGRA and tuberculin skin test (TST) performance in inflammatory bowel disease (IBD) patients. We assessed test concordance and the effects of immunosuppression on their performance in IBD patients.
Methods
We searched MEDLINE, Embase and Cochrane databases (2011–2018) for studies testing TST and IGRA in IBD. Primary outcome was TST and IGRA concordance. Secondary outcomes were effects of immunosuppressive therapy on performance. Immunosuppression defined as either steroids, thiopurine, methotrexate or cyclosporine use. We used the pooled random effects model to adjust for heterogeneity analyzed using (I2–Q statistics). We compared the fixed model to exclude smaller study effects.
Results
Sixteen studies (2,488 patients) were included. Pooled TST and IGRA concordance was 85% (95% confidence interval [CI], 81%–88%; P=0.01). Effects of immunosuppression were reported in 8 studies (814 patients). The odds ratio of testing positive by IGRA decreased to 0.57 if immunosuppressed (95% CI, 0.31–1.03; P=0.06). The odds ratio of testing positive by TST if immunosuppressed was 1.14 (95% CI, 0.61–2.12; P=0.69). The fixed model yielded similar results, however the negative effect of immunosuppression on IGRA reached statistical significance (P=0.01).
Conclusions
While concordance was 85% between TST and IGRA, the performance of IGRA seems to be negatively affected by immunosuppression. Given the importance of detecting latent tuberculosis prior to anti-TNF initiation, further randomized controlled trials comparing the performance of TST and IGRA in IBD patients are needed.

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  • Bronchoesophageal fistula in a patient with Crohn’s disease receiving anti-tumor necrosis factor therapy
    Kyunghwan Oh, Kee Don Choi, Hyeong Ryul Kim, Tae Sun Shim, Byong Duk Ye, Suk-Kyun Yang, Sang Hyoung Park
    Clinical Endoscopy.2023; 56(2): 239.     CrossRef
  • Impact of Immunosuppressive Therapy on the Performance of Latent Tuberculosis Screening Tests in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
    Chan Hyuk Park, Jung Ho Park, Yoon Suk Jung
    Journal of Personalized Medicine.2022; 12(3): 507.     CrossRef
  • The Risk of Tuberculosis in Patients With Inflammatory Bowel Disease Treated With Vedolizumab or Ustekinumab in Korea
    Myeong Geun Choi, Byong Duk Ye, Suk-Kyun Yang, Tae Sun Shim, Kyung-Wook Jo, Sang Hyoung Park
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Prophylactic Antitubercular Therapy Is Associated With Accelerated Disease Progression in Patients With Crohn's Disease Receiving Anti-TNF Therapy: A Retrospective Multicenter Study
    Fen Liu, Jian Tang, Lingna Ye, Jinyu Tan, Yun Qiu, Fan Hu, Jinshen He, Baili Chen, Yao He, Zhirong Zeng, Ren Mao, Qian Cao, Xiang Gao, Minhu Chen
    Clinical and Translational Gastroenterology.2022; 13(6): e00493.     CrossRef
  • Updates on conventional therapies for inflammatory bowel diseases: 5-aminosalicylates, corticosteroids, immunomodulators, and anti-TNF-α
    Jihye Park, Jae Hee Cheon
    The Korean Journal of Internal Medicine.2022; 37(5): 895.     CrossRef
  • Latent and Active Tuberculosis Infection in Patients with Inflammatory Bowel Disease
    Byung Chul Jin, Hee Jin Moon, Sang Wook Kim
    The Korean Journal of Gastroenterology.2022; 80(2): 72.     CrossRef
  • Differentiating between Intestinal Tuberculosis and Crohn’s Disease May Be Complicated by Multidrug-resistant Mycobacterium tuberculosis
    Seung Wook Hong, Sang Hyoung Park, Byong Duk Ye, Suk-Kyun Yang
    The Ewha Medical Journal.2021; 44(3): 93.     CrossRef
  • Risk and characteristics of tuberculosis after anti-tumor necrosis factor therapy for inflammatory bowel disease: a hospital-based cohort study from Korea
    Jae Yong Lee, Kyunghwan Oh, Hee Seung Hong, Kyuwon Kim, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Ho-Su Lee, Kyung-Wook Jo, Sang Hyoung Park
    BMC Gastroenterology.2021;[Epub]     CrossRef
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    Seong-Eun Kim
    The Ewha Medical Journal.2021; 44(4): 148.     CrossRef
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Colorectal neoplasia
Factors associated with the survival of colorectal cancer in Mexico
Carlos Quezada-Gutiérrez, María Teresa Álvarez-Bañuelos, Jaime Morales-Romero, Clara Luz Sampieri, Raúl Enrique Guzmán-García, Evangelina Montes-Villaseñor
Intest Res 2020;18(3):315-324.   Published online May 19, 2020
DOI: https://doi.org/10.5217/ir.2019.09179
AbstractAbstract PDFPubReaderePub
Background/Aims
Colorectal cancer (CRC) is a public health problem. In Mexico, there have been no recent studies conducted on survival in terms of this pathology or on the influence of prognostic factors. The study aims to determine the probability of survival in patients with CRC presence of low levels of schooling and a rural population, adjusted for clinical stage and type of treatment.
Methods
A retrospective study was conducted in a cohort of 305 patients with CRC treated at State Cancer Center, located in Veracruz-Mexico; the follow-up period of 60 months (2012–2016). The survival probability was calculated using the Kaplan-Meier estimator and the log-rank test with 95% confidence intervals (CIs). Prognostic factors were determined using hazard ratio (HR) multivariate Cox regression analysis.
Results
Overall survival was 40% at 60 months. Subjects in the age group ≥ 65 years had a low survival rate of 28% (P= 0.026) and an advanced clinical stage of 22% (P< 0.001). Of the patients with bone metastasis, none survived longer than 5 years (P= 0.008). With respect to the unfavorable prognostic factors identified in the multivariate analysis, a decreased level of schooling was associated with an HR of 7.6 (95% CI, 1.1–54.7), advanced clinical stage was associated with an HR of 2.1 (95% CI, 1.2–4.0), and the presence of metastasis had an HR of 1.8 (95% CI, 1.1–2.9).
Conclusions
Poor prognostic factors include an advanced clinical stage, the presence of metastasis and a low level of schooling. These findings confirm the importance of screening for early diagnosis, diminishing the barriers to accessing treatment and prospectively monitoring the population.

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    Maria Elena Martinez, Kathleen M. Schmeler, Martin Lajous, Lisa A. Newman
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    P.F Gomez- Galicia, I. Parola-Contreras, Juan Gabriel Báez- González, R. Durán-Lugo
    Investigación y Desarrollo en Ciencia y Tecnología de Alimentos.2023; 8(1): 379.     CrossRef
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    Edvina Elena Pîrvu, Emilia Severin, Raluca Ileana Pătru, Irina Niță, Stefania Andreea Toma, Roxana Rodica Macarie, Cristina Elena Cocioabă, Ioana Florescu, Simona Coniac
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Miscellaneous
Melatonin in the colon modulates intestinal microbiota in response to stress and sleep deprivation
Young Sook Park, Soo Hyung Kim, Jong Won Park, Younglim Kho, Pu Rum Seok, Jae-Ho Shin, Yoon Ji Choi, Jin-Hyun Jun, Hee Chan Jung, Eun Kyung Kim
Intest Res 2020;18(3):325-336.   Published online June 23, 2020
DOI: https://doi.org/10.5217/ir.2019.00093
AbstractAbstract PDFPubReaderePub
Background/Aims
Stress is closely related to the deterioration of digestive disease. Melatonin has potent anti-inflammatory properties. The objective of this study was to determine the effect of water stress (WS) and sleep deprivation (SD) on intestinal microbiota and roles of melatonin in stressful condition.
Methods
We used C57BL/6 mice and specially designed water bath for stress and SD for 10 days. We measured melatonin concentrations in serum, feces, and colon tissues by high-performance liquid chromatography. Genomic DNA was extracted from feces and amplified using primers targeting V3 to V4 regions of bacterial 16S ribosomal RNA genes.
Results
Compared to the control, melatonin concentration was lower in the WS and SD. Fecal concentration was 0.132 pg/mL in control, 0.062 pg/mL in WS, and 0.068 pg/mL in SD. In colon tissue, it was 0.45 pg/mL in control, 0.007 pg/mL in WS, and 0.03 pg/mL in SD. After melatonin treatment, melatonin concentrations in feces and colon tissue were recovered to the level of control. Metagenomic analysis of microbiota showed abundance in colitogenic microbiota in WS and SD. Melatonin injection attenuated this harmful effect. WS and SD showed decreased Lactobacillales and increased Erysipelotrichales and Enterobacteriales. Melatonin treatment increased Akkermansia muciniphila and Lactobacillus and decreased Bacteroides massiliensis and Erysipelotrichaceae.
Conclusions
This study showed that stress and SD could affect intestinal dysbiosis and increase colitogenic microbiota, which could contribute to the aggravating digestive disease. Melatonin concentrations in feces and colon tissue decreased under WS and SD. Melatonin treatment brought recovery of melatonin concentration in colon tissue and modulating dysbiosis of intestinal microbiota.

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  • The use of melatonin in the treatment of irritable bowel syndrome: a systematic review of randomized placebo-controlled clinical trials
    D. S. Mironov, I. A. Spirin, T. N. Trubeckaya, N. S. Shitova, V. A. Postoev
    Experimental and Clinical Gastroenterology.2024; (9): 168.     CrossRef
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Case Report
Inflammatory bowel diseases
Incidental benefits after fecal microbiota transplant for ulcerative colitis
Ramit Mahajan, Vandana Midha, Arshdeep Singh, Varun Mehta, Yogesh Gupta, Kirandeep Kaur, Ritu Sudhakar, Anmol Singh Pannu, Dharmatma Singh, Ajit Sood
Intest Res 2020;18(3):337-340.   Published online April 22, 2020
DOI: https://doi.org/10.5217/ir.2019.00108
AbstractAbstract PDFPubReaderePub
Gut dysbiosis can result in several diseases, including infections (Clostridium difficile infection and infectious gastroenteritis), autoimmune diseases (inflammatory bowel disease, diabetes, and allergic disorders), behavioral disorders and other conditions like metabolic syndrome and functional gastrointestinal disorders. Amongst various therapies targeting gut microbiome, fecal microbiota transplantation (FMT) is becoming a focus in the public media and peer reviewed literature. We have been using FMT for induction of remission in patients with moderate to severe active ulcerative colitis (UC) and also for subsequent maintenance of remission. Four cases reported incidental benefits while being treated with FMT for UC. These included weight loss (n=1), improvement in hair loss (n=1), amelioration of axial arthritis (n=1) and improvement in allergic rhinitis (n=1), thereby suggesting potential clinical applications of FMT in treating extraintestinal diseases associated with gut dysbiosis.

Citations

Citations to this article as recorded by  
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    Madeline Pilkington, Declan Lloyd, Brad Guo, Stephanie L. Watson, Kenneth Gek-Jin Ooi
    Exploration of Medicine.2024; : 127.     CrossRef
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  • Case report: Fecal microbiota transplantation in refractory ankylosing spondylitis
    Lei Wang, Zhimin Wei, Fei Pan, Chuan Song, Lihua Peng, Yunsheng Yang, Feng Huang
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    Tadatsugu Morimoto, Takaomi Kobayashi, Toshihiko Kakiuchi, Motohiro Esaki, Masatsugu Tsukamoto, Tomohito Yoshihara, Hirohito Hirata, Shoji Yabuki, Masaaki Mawatari
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Images of the Issue
Inflammatory bowel diseases
Sausage-like fingers in Crohn’s disease
Akira Hokama, Taiga Miyagi, Yukiko Takeichi, Eriko Uema, Sayuri Takehara, Tetsuya Ohira, Atsushi Iraha, Tetsu Kinjo, Jiro Fujita
Intest Res 2020;18(3):341-342.   Published online May 25, 2020
DOI: https://doi.org/10.5217/ir.2020.00036
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Corrigendum
Corrigendum: Randomized, crossover questionnaire survey of acceptabilities of controlled-release mesalazine tablets and granules in ulcerative colitis patients
Keiji Yagisawa, Taku Kobayashi, Ryo Ozaki, Shinji Okabayashi, Takahiko Toyonaga, Miki Miura, Mari Hayashida, Eiko Saito, Masaru Nakano, Hajime Matsubara, Tadakazu Hisamatsu, Toshifumi Hibi
Intest Res 2020;18(3):343-344.   Published online July 20, 2020
DOI: https://doi.org/10.5217/ir.2018.00078-c1
Corrects: Intest Res 2019;17(1):87
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