Skip Navigation
Skip to contents

Intest Res : Intestinal Research

IMPACT FACTOR

Previous issues

Page Path
HOME > Browse articles > Previous issues
12 Previous issues
Filter
Filter
Article category
Keywords
Authors
Funded articles
Volume 18(4); October 2020
Prev issue Next issue
Editorial
Inflammatory bowel diseases
The first step to unveil the epidemiology of inflammatory bowel disease in Central Asia
Seung Wook Hong, Byong Duk Ye
Intest Res 2020;18(4):345-346.   Published online October 26, 2020
DOI: https://doi.org/10.5217/ir.2020.00121
PDFPubReaderePub

Citations

Citations to this article as recorded by  
  • Old and New Biologics and Small Molecules in Inflammatory Bowel Disease: Anti-Tumor Necrosis Factors
    Sang Un Kim, Hyun Seok Lee
    The Korean Journal of Gastroenterology.2024; 84(2): 35.     CrossRef
  • Bronchoesophageal fistula in a patient with Crohn’s disease receiving anti-tumor necrosis factor therapy
    Kyunghwan Oh, Kee Don Choi, Hyeong Ryul Kim, Tae Sun Shim, Byong Duk Ye, Suk-Kyun Yang, Sang Hyoung Park
    Clinical Endoscopy.2023; 56(2): 239.     CrossRef
  • Impact of Crohn’s Disease on the Survival of Patients with Small-Bowel Adenocarcinoma in Korea: A Bicenter Cohort Study
    Kyuwon Kim, Kookhwan Choi, Sung Wook Hwang, Jong Pil Im, Byong Duk Ye, Joo Sung Kim, Kyu Joo Park, Suk-Kyun Yang, Seong-Joon Koh, Sang Hyoung Park
    Gut and Liver.2023; 17(4): 581.     CrossRef
  • Diagnosis of inflammatory bowel disease–Asian perspectives: the results of a multinational web-based survey in the 8th Asian Organization for Crohn’s and Colitis meeting
    Han Hee Lee, Jae Jun Park, Bo-In Lee, Ida Hilmi, Jose Sollano, Zhi Hua Ran
    Intestinal Research.2023; 21(3): 328.     CrossRef
  • Evolving Trends and Burden of Inflammatory Bowel Disease in Asia, 1990–2019: A Comprehensive Analysis Based on the Global Burden of Disease Study
    Xuejie Chen, Xin Xiang, Weitong Xia, Xindi Li, Sidan Wang, Shuyu Ye, Li Tian, Lian Zhao, Feiyan Ai, Zhaohua Shen, Kai Nie, Minzi Deng, Xiaoyan Wang
    Journal of Epidemiology and Global Health.2023; 13(4): 725.     CrossRef
  • The Comparative Risk of Serious Adverse Events With Tofacitinib and TNF Inhibitors in Patients With Ulcerative Colitis: The Korean Experience as Revealed by a National Database
    Gi Hyeon Seo, Sung Hoon Jung
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Update on the epidemiology of inflammatory bowel disease in Asia: where are we now?
    Sang Hyoung Park
    Intestinal Research.2022; 20(2): 159.     CrossRef
  • Oral beclomethasone dipropionate as an add-on therapy and response prediction in Korean patients with ulcerative colitis
    Kyuwon Kim, Hee Seung Hong, Kyunghwan Oh, Jae Yong Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye, Sang Hyoung Park
    The Korean Journal of Internal Medicine.2022; 37(6): 1140.     CrossRef
  • Inflammatory bowel disease in Korea: epidemiology and pathophysiology
    Jung Won Lee, Chang Soo Eun
    The Korean Journal of Internal Medicine.2022; 37(5): 885.     CrossRef
  • Clostridioides Infection in Patients with Inflammatory Bowel Disease
    Mi Rae Lee, Eun Soo Kim
    The Korean Journal of Gastroenterology.2022; 80(2): 66.     CrossRef
  • Risk and characteristics of tuberculosis after anti-tumor necrosis factor therapy for inflammatory bowel disease: a hospital-based cohort study from Korea
    Jae Yong Lee, Kyunghwan Oh, Hee Seung Hong, Kyuwon Kim, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Ho-Su Lee, Kyung-Wook Jo, Sang Hyoung Park
    BMC Gastroenterology.2021;[Epub]     CrossRef
  • Capsule Endoscopy in Inflammatory Bowel Disease: When? To Whom?
    Soo-Young Na, Yun-Jeong Lim
    Diagnostics.2021; 11(12): 2240.     CrossRef
  • Pharmacogenetics-based personalized treatment in patients with inflammatory bowel disease: A review
    Ji Young Chang, Jae Hee Cheon
    Precision and Future Medicine.2021; 5(4): 151.     CrossRef
  • 4,283 View
  • 130 Download
  • 13 Web of Science
  • 13 Crossref
Close layer
Reviews
Inflammatory bowel diseases
Clinical management for small bowel of Crohn’s disease in the treat-to-target era: now is the time to optimize treatment based on the dominant lesion
Kenji Watanabe
Intest Res 2020;18(4):347-354.   Published online October 26, 2020
DOI: https://doi.org/10.5217/ir.2020.00032
AbstractAbstract PDFPubReaderePub
A treat-to-target strategy, in which treatment is continuously adjusted according to the results of scheduled objective monitoring, is optimal for patients with Crohn’s disease (CD) in the era of biologics. The small bowel is a common site of intractable CD, which may result from multiple strictures or expanding lesions. To improve the prognosis of patients with small bowel CD, lesions should be proactively monitored within the subclinical phase. Objective assessment of small bowel lesions is technically difficult, however, due to the relatively poor correlation between endoscopic activity and clinical symptoms or biomarker titers. The presence of proximal small bowel lesions and asymptomatic “Real Silent CD” must be considered. Endoscopy remains the gold standard to assess these lesions. In clinical practice, the advantages and disadvantages of each imaging modality and biomarker must be carefully weighed for appropriate application and reliable monitoring. The prevalence of small bowel lesions depends on the precision of the imaging modality used for detection. Clinical management should be based on the dominant location of the intestinal lesions rather than classical classification. Optimal strategies for detecting and treating small bowel lesions in patients with CD must be developed utilizing reliable, precise, and objective monitoring.

Citations

Citations to this article as recorded by  
  • Comparison of an Endoscopic Scoring System and the Simplified Magnetic Resonance Index of Activity in Patients with Small Bowel Crohn’s Disease
    Ji Eun Na, Hon Soul Kim, Sung Noh Hong, Kyoung Doo Song, Ji Eun Kim, Eun Ran Kim, Young-Ho Kim, Dong Kyung Chang
    Gut and Liver.2024; 18(1): 97.     CrossRef
  • Use of double-balloon endoscopy and an endoscopic scoring system to assess endoscopic remission in isolated small bowel Crohn’s disease after treatment with infliximab
    Wei Han, Jing Hu, Juan Wu, Peipei Zhang, Qiuyuan Liu, Naizhong Hu, Qiao Mei
    Therapeutic Advances in Gastroenterology.2024;[Epub]     CrossRef
  • Outcomes of Patients With Prior Biologic Intolerance Are Better Than Those With Biologic Failure in Clinical Trials of Inflammatory Bowel Disease
    Sunil Samnani, Emily C L Wong, Hasan Hamam, Parambir S Dulai, John K Marshall, Vipul Jairath, Walter Reinisch, Neeraj Narula
    Journal of Crohn's and Colitis.2024;[Epub]     CrossRef
  • Intestinal ultrasound accurately predicts future therapy failure in Crohn’s disease patients in a biologics-induced remission
    Ahmad Albshesh, Alon Abend, Reuma Margalit Yehuda, Hussein Mahajna, Bella Ungar, Shomron Ben-Horin, Uri Kopylov, Dan Carter
    European Journal of Gastroenterology & Hepatology.2024;[Epub]     CrossRef
  • Compositional changes in fecal microbiota associated with clinical phenotypes and prognosis in Korean patients with inflammatory bowel disease
    Seung Yong Shin, Young Kim, Won-Seok Kim, Jung Min Moon, Kang-Moon Lee, Sung-Ae Jung, Hyesook Park, Eun Young Huh, Byung Chang Kim, Soo Chan Lee, Chang Hwan Choi
    Intestinal Research.2023; 21(1): 148.     CrossRef
  • Impact of Crohn’s Disease on the Survival of Patients with Small-Bowel Adenocarcinoma in Korea: A Bicenter Cohort Study
    Kyuwon Kim, Kookhwan Choi, Sung Wook Hwang, Jong Pil Im, Byong Duk Ye, Joo Sung Kim, Kyu Joo Park, Suk-Kyun Yang, Seong-Joon Koh, Sang Hyoung Park
    Gut and Liver.2023; 17(4): 581.     CrossRef
  • Diagnosis of Crohn’s disease and ulcerative colitis using the microbiome
    Da-Yeon Kang, Jong-Lyul Park, Min-Kyung Yeo, Sang-Bum Kang, Jin-Man Kim, Ju Seok Kim, Seon-Young Kim
    BMC Microbiology.2023;[Epub]     CrossRef
  • Combined Endoscopic and Radiologic Healing Is Associated With a Better Prognosis Than Endoscopic Healing Only in Patients With Crohn's Disease Receiving Anti-TNF Therapy
    Kyunghwan Oh, Eun Hye Oh, Soo Min Noh, Seong Ho Park, Nayoung Kim, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
    Clinical and Translational Gastroenterology.2022; 13(1): e00442.     CrossRef
  • Clinical factors to predict flare-up in patients with inflammatory bowel disease during international air travel: A prospective study
    Jihye Park, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Alaa El-Hussuna
    PLOS ONE.2022; 17(1): e0262571.     CrossRef
  • Long-term Disease Course of Crohn’s Disease: Changes in Disease Location, Phenotype, Activities, and Predictive Factors
    Choong Wui Cho, Myung-Won You, Chi Hyuk Oh, Chang Kyun Lee, Sung Kyoung Moon
    Gut and Liver.2022; 16(2): 157.     CrossRef
  • Comparative effectiveness of second-line biological therapies for ulcerative colitis and Crohn’s disease in patients with prior failure of anti-tumour necrosis factor treatment
    Hye Kyung Hyun, Hyun-Soo Zhang, Jongwook Yu, Eun Ae Kang, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
    BMC Gastroenterology.2022;[Epub]     CrossRef
  • Is radiological healing alone enough? ‘Can’t take my eyes off’ the mucosa
    Su Hyun Park, Sang Hyoung Park
    The Korean Journal of Internal Medicine.2022; 37(3): 551.     CrossRef
  • Fecal S100A12 is associated with future hospitalization and step-up of medical treatment in patients with Crohn’s disease in clinical remission: a pilot study
    Sun-Ho Lee, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
    Intestinal Research.2022; 20(2): 203.     CrossRef
  • Continued Postoperative Use of Tumor Necrosis Factor-α Inhibitors for the Prevention of Crohn’s Disease Recurrence
    Jongwook Yu, Hye Kyung Hyun, Jihye Park, Eun Ae Kang, Soo Jung Park, Jae Jun Park, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
    Gut and Liver.2022; 16(3): 414.     CrossRef
  • Intestinal ultrasonography and fecal calprotectin for monitoring inflammation of ileal Crohn’s disease: two complementary tests
    José María Paredes, Tomás Ripollés, Ángela Algarra, Rafael Diaz, Nadia Moreno, Patricia Latorre, María Jesús Martínez, Pilar Llopis, Antonio López, Eduardo Moreno-Osset
    Intestinal Research.2022; 20(3): 361.     CrossRef
  • Radiation Exposure among Patients with Inflammatory Bowel Disease: A Single-Medical-Center Retrospective Analysis in Taiwan
    Chen-Ta Yang, Hsu-Heng Yen, Yang-Yuan Chen, Pei-Yuan Su, Siou-Ping Huang
    Journal of Clinical Medicine.2022; 11(17): 5050.     CrossRef
  • Capsule endoscopy in Crohn's disease surveillance: A monocentric, retrospective analysis in Italy
    Carlo Calabrese, Dania Gelli, Fernando Rizzello, Paolo Gionchetti, Rafael Torrejon Torres, Rhodri Saunders, Jason Davis
    Frontiers in Medical Technology.2022;[Epub]     CrossRef
  • Risk factors and prognostic value of acute severe lower gastrointestinal bleeding in Crohn’s disease
    Jiyoung Yoon, Dae Sung Kim, Ye-Jee Kim, Jin Wook Lee, Seung Wook Hong, Ha Won Hwang, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang
    World Journal of Gastroenterology.2021; 27(19): 2353.     CrossRef
  • Is Paradigm for the Role of Balloon-Assisted Enteroscopy Changing in Crohn’s Disease?
    Yoo Jin Lee
    Gut and Liver.2021; 15(3): 325.     CrossRef
  • Epithelial Regeneration Ability of Crohn’s Disease Assessed Using Patient-Derived Intestinal Organoids
    Chansu Lee, Sung-Noh Hong, Eun-Ran Kim, Dong-Kyung Chang, Young-Ho Kim
    International Journal of Molecular Sciences.2021; 22(11): 6013.     CrossRef
  • Editorial: higher concentrations of cytokine blockers are needed to obtain small bowel mucosal healing during maintenance therapy in Crohn's disease
    Shana Rakowsky, Adam S. Cheifetz, Konstantinos Papamichael
    Alimentary Pharmacology & Therapeutics.2021; 54(8): 1085.     CrossRef
  • Another Piece of Evidence for Early Administration of Biologics in Children with Crohn's Disease Who Start as an Inflammatory Phenotype
    Hyuk Yoon
    Gut and Liver.2021; 15(6): 791.     CrossRef
  • Capsule Endoscopy in Inflammatory Bowel Disease: When? To Whom?
    Soo-Young Na, Yun-Jeong Lim
    Diagnostics.2021; 11(12): 2240.     CrossRef
  • 6,298 View
  • 229 Download
  • 22 Web of Science
  • 23 Crossref
Close layer
Inflammatory bowel diseases
Colitis and Crohn’s Foundation (India) consensus statements on use of 5-aminosalicylic acid in inflammatory bowel disease
Ajit Sood, Vineet Ahuja, Vandana Midha, Saroj Kant Sinha, C. Ganesh Pai, Saurabh Kedia, Varun Mehta, Sawan Bopanna, Philip Abraham, Rupa Banerjee, Shobna Bhatia, Karmabir Chakravartty, Sunil Dadhich, Devendra Desai, Manisha Dwivedi, Bhabhadev Goswami, Kirandeep Kaur, Rajeev Khosla, Ajay Kumar, Ramit Mahajan, S. P. Misra, Kiran Peddi, Shivaram Prasad Singh, Arshdeep Singh
Intest Res 2020;18(4):355-378.   Published online July 13, 2020
DOI: https://doi.org/10.5217/ir.2019.09176
AbstractAbstract PDFPubReaderePub
Despite several recent advances in therapy in inflammatory bowel disease (IBD), 5-aminosalicylic acid (5-ASA) therapy has retained its place especially in ulcerative colitis. This consensus on 5-ASA is obtained through a modified Delphi process, and includes guiding statements and recommendations based on literature evidence (randomized trials, and observational studies), clinical practice, and expert opinion on use of 5-ASA in IBD by Indian gastroenterologists. The aim is to aid practitioners in selecting appropriate treatment strategies and facilitate optimal use of 5-ASA in patients with IBD.

Citations

Citations to this article as recorded by  
  • Effectiveness of Tofacitinib in Ulcerative Proctitis Compared to Left Sided Colitis and Pancolitis
    Arshdeep Singh, Ramit Mahajan, Vandana Midha, Kirandeep Kaur, Dharmatma Singh, Ramandeep Kaur, Shreya Garg, Kirti Arora, Namita Bansal, Ajit Sood
    Digestive Diseases and Sciences.2024; 69(4): 1389.     CrossRef
  • The impact of 5-aminosalicylates on the efficacy of mesenchymal stem cell therapy in a murine model of ulcerative colitis
    Huanhuan Chen, Huimin Wang, XiaoJing Xu, Ya'nan Hu, Jing Su, Dongdong Li, Zimu Li, Shixiang Feng, Jinming Liu, Huanxiang Zhang, Xiaoyan Wang
    International Immunopharmacology.2024; 134: 112255.     CrossRef
  • The impact of clinical experience on decision-making regarding the treatment and management of mild-to-moderate ulcerative colitis
    Jae Hee Cheon, Kristine Paridaens, Sameer Al Awadhi, Jakob Begun, John R Fullarton, Edouard Louis, Fernando Magro, Juan Ricardo Marquez, Alexander R Moschen, Neeraj Narula, Grazyna Rydzewska, Axel U Dignass, Simon PL Travis
    Intestinal Research.2023; 21(1): 161.     CrossRef
  • Development of Novel pH-Sensitive Eudragit Coated Beads Containing Curcumin-Mesalamine Combination for Colon-Specific Drug Delivery
    Eman J. Heikal, Rashad M. Kaoud, Shadeed Gad, Hatem I. Mokhtar, Abdullah Alattar, Reem Alshaman, Sawsan A. Zaitone, Yasser M. Moustafa, Taha M. Hammady
    Gels.2023; 9(4): 264.     CrossRef
  • Consenso colombiano de la enfermedad inflamatoria intestinal pediátrica
    José Fernando Vera Chamorro, Claudia Sánchez Franco, Melquicedec Vargas Sandoval, Diana Victoria Mora Quintero, Juan Pablo Riveros López, Fernando Sarmiento Quintero, Catalina Ortiz-Piedrahita, Otto Gerardo Calderón-Guerrero, Hugo Laignelet, Claudia Lilia
    Revista colombiana de Gastroenterología.2023; 38(Supl No. 1): 1.     CrossRef
  • Clinical Features and Long-Term Outcomes of Paediatric-Onset Inflammatory Bowel Disease in a Population-Based Cohort in the Songpa-Kangdong District of Seoul, Korea
    Sang Hyoung Park, Jong Pil Im, Hyunju Park, Seung Kyu Jeong, Ji Hyun Lee, Kyoung Hoon Rhee, Young-Ho Kim, Sung Noh Hong, Kyung Ho Kim, Seung In Seo, Jae Myung Cha, Sun Yong Park, Joo Sung Kim, Hyuk Yoon, Sung Hoon Kim, Jisun Jang, Jeong Hwan Kim, Seong O
    Journal of Crohn's and Colitis.2022; 16(2): 207.     CrossRef
  • Serum inter-alpha-trypsin inhibitor heavy chain 4 in patients with inflammatory bowel disease: correlation with disease risk, inflammation, activity, and its variation after treatment
    Nuan Wen, Na Zhao, Huixian Xu, Ying Zhao, Jian Ma
    Irish Journal of Medical Science (1971 -).2022; 191(5): 2105.     CrossRef
  • 5-Aminosalicylic Acid-induced Myocarditis in a Patient with Atypical Ulcerative Colitis
    Hyo Yeop Song, Geom Seog Seo
    The Korean Journal of Gastroenterology.2022; 79(1): 31.     CrossRef
  • The Prognostic Value of Residual Nonrectal Inflammation in Ulcerative Colitis
    Eun Ae Kang
    Gut and Liver.2022; 16(3): 487.     CrossRef
  • Updates on conventional therapies for inflammatory bowel diseases: 5-aminosalicylates, corticosteroids, immunomodulators, and anti-TNF-α
    Jihye Park, Jae Hee Cheon
    The Korean Journal of Internal Medicine.2022; 37(5): 895.     CrossRef
  • Oral beclomethasone dipropionate as an add-on therapy and response prediction in Korean patients with ulcerative colitis
    Kyuwon Kim, Hee Seung Hong, Kyunghwan Oh, Jae Yong Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye, Sang Hyoung Park
    The Korean Journal of Internal Medicine.2022; 37(6): 1140.     CrossRef
  • Treatment of inflammatory bowel diseases: focusing on 5-aminosalicylates and immunomodulators
    You Sun Kim
    Journal of the Korean Medical Association.2021; 64(9): 596.     CrossRef
  • Pharmacogenetics-based personalized treatment in patients with inflammatory bowel disease: A review
    Ji Young Chang, Jae Hee Cheon
    Precision and Future Medicine.2021; 5(4): 151.     CrossRef
  • 9,814 View
  • 331 Download
  • 13 Web of Science
  • 13 Crossref
Close layer
Inflammatory bowel diseases
Fibrostenotic strictures in Crohn’s disease
Jun Hwan Yoo, Stefan Holubar, Florian Rieder
Intest Res 2020;18(4):379-401.   Published online April 10, 2020
DOI: https://doi.org/10.5217/ir.2019.09148
AbstractAbstract PDFPubReaderePub
The use of biologic agents including anti-tumor necrosis factor monoclonal antibodies followed by anti-integrins and anti-interleukins has drastically changed the treatment paradigm of Crohn’s disease (CD) by improving clinical symptoms and mucosal healing. However, up to 70% of CD patients still eventually undergo surgery mainly due to fibrostenotic strictures. There are no specific anti-fibrotic drugs yet. This review comprehensively addresses the mechanism, prediction, diagnosis and treatment of the fibrostenotic strictures in CD. We also introduce promising anti-fibrotic agents which may be available in the near future and summarize challenges in developing novel therapies to treat fibrostenotic strictures in CD.

Citations

Citations to this article as recorded by  
  • Role of Endoscopic Ultrasound in the Diagnosis and Management of Complications of Inflammatory Bowel Disease
    Jay Bapaye, Saurabh Chandan, Gursimran S. Kochhar
    Gastrointestinal Endoscopy Clinics of North America.2025; 35(1): 235.     CrossRef
  • Histological Image-based Ensemble Model to Identify Myenteric Plexitis and Predict Endoscopic Postoperative Recurrence in Crohn’s Disease: A Multicentre, Retrospective Study
    Yuexin Wang, Qi He, Danhua Yao, Yuhua Huang, Wenwen Xia, Weilin Chen, Zhe Cui, Yousheng Li
    Journal of Crohn's and Colitis.2024; 18(5): 727.     CrossRef
  • Contemporary Imaging Assessment of Strictures and Fibrosis in Crohn Disease, With Focus on Quantitative Biomarkers: From the AJR Special Series on Imaging of Fibrosis
    Jordi Rimola, Kim J. Beek, Ingrid Ordás, Krisztina B. Gecse, Míriam Cuatrecasas, Jaap Stoker
    American Journal of Roentgenology.2024;[Epub]     CrossRef
  • Surgical Emergencies in Inflammatory Bowel Disease
    John Van Eaton, Quinton M. Hatch
    Surgical Clinics of North America.2024; 104(3): 685.     CrossRef
  • Fibrosis in IBD: from pathogenesis to therapeutic targets
    Florian Rieder, Pranab K Mukherjee, William J Massey, Yan Wang, Claudio Fiocchi
    Gut.2024; 73(5): 854.     CrossRef
  • Enter the Matrix: Fibroblast-immune interactions shape ECM deposition in health and disease.
    Anthony Altieri, Grace V. Visser, Matthew B. Buechler
    F1000Research.2024; 13: 119.     CrossRef
  • Preventing fibrosis in IBD: update on immune pathways and clinical strategies
    Jie Wang, Bo Yang, Jyotsna Chandra, Andrei Ivanov, J. Mark Brown, Florian Rieder
    Expert Review of Clinical Immunology.2024; 20(7): 727.     CrossRef
  • Intestinal strictures in Crohn's disease: An update from 2023
    Zishan Liu, Zhuoyan Huang, Yu Wang, Shanshan Xiong, Sinan Lin, Jinshen He, Jinyu Tan, Caiguang Liu, Xiaomin Wu, Jing Nie, Weidong Huang, Yao Zhang, Longyuan Zhou, Ren Mao
    United European Gastroenterology Journal.2024; 12(6): 802.     CrossRef
  • Naringin Alleviates Intestinal Fibrosis by Inhibiting ER Stress–Induced PAR2 Activation
    Jinguo Liu, Lei Xu, Li Wang, Qianqian Wang, Liangliang Yu, Shuo Zhang
    Inflammatory Bowel Diseases.2024; 30(11): 1946.     CrossRef
  • Characterization of patient-derived intestinal organoids for modelling fibrosis in Inflammatory Bowel Disease
    Ilaria Laudadio, Claudia Carissimi, Noemi Scafa, Alex Bastianelli, Valerio Fulci, Alessandra Renzini, Giusy Russo, Salvatore Oliva, Roberta Vitali, Francesca Palone, Salvatore Cucchiara, Laura Stronati
    Inflammation Research.2024; 73(8): 1359.     CrossRef
  • Efficacy and Safety of Endoscopic Stricturotomy in Inflammatory Bowel Disease-Related Strictures: A Systematic Review and Meta-Analysis
    Fouad Jaber, Laith Numan, Mohammed Ayyad, Mohamed Abuelazm, Muhammad Imran, Majd M. AlBarakat, Aya M. Aboutaleb, Ubaid Khan, Saqr Alsakarneh, Mohammad Bilal
    Digestive Diseases and Sciences.2024; 69(11): 4152.     CrossRef
  • A Comprehensive Multidisciplinary Approach to Diagnosing Chronic Inflammatory Bowel Diseases: Integration of Clinical, Endoscopic, and Imaging Modalities
    Clelia Cicerone, Ferdinando D’Amico, Mariangela Allocca, Alessandra Zilli, Tommaso Lorenzo Parigi, Silvio Danese, Federica Furfaro
    Diagnostics.2024; 14(14): 1530.     CrossRef
  • Management of Crohn’s disease in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease updated in 2023
    Jia-Feng Wu, Hsu-Heng Yen, Horng-Yuan Wang, Ting-An Chang, Chung-Hsin Chang, Chen-Wang Chang, Te-Hsin Chao, Jen-Wei Chou, Yenn-Hwei Chou, Chiao-Hsiung Chuang, Wen-Hung Hsu, Tzu-Chi Hsu, Tien-Yu Huang, Tsung-I Hung, Puo-Hsien Le, Chun-Che Lin, Chun-Chi Lin
    Intestinal Research.2024; 22(3): 250.     CrossRef
  • Enfermedad de Crohn estenosante y endometriosis intestinal: coexistencia inusual
    F. Carvajal, F. López, P. Núñez, L. Contreras, R. Quera
    Revista de Gastroenterología de México.2024; 89(4): 550.     CrossRef
  • Muscular hyperplasia in Crohn’s disease strictures: through thick and thin
    Ido Veisman, William J. Massey, Idan Goren, Weiwei Liu, Gaurav Chauhan, Florian Rieder
    American Journal of Physiology-Cell Physiology.2024; 327(3): C671.     CrossRef
  • Inhibition of intestinal inflammation and fibrosis by Scutellaria Baicalensis georgi and Boswellia serrata in human epithelial cells and fibroblasts
    Ilaria Laudadio, Beatrice Leter, Francesca Palone, Salvatore Cucchiara, Claudia Carissimi, Noemi Scafa, Daniela Secci, Roberta Vitali, Laura Stronati
    Immunity, Inflammation and Disease.2024;[Epub]     CrossRef
  • Eicosatetraynoic Acid Regulates Profibrotic Pathways in an Induced Pluripotent Stem Cell–Derived Macrophage-Human Intestinal Organoid Model of Crohn’s Disease
    Ingrid Jurickova, Benjamin W Dreskin, Elizabeth Angerman, Erin Bonkowski, Jack Nguyen, Richard Villarreal, Kentaro Tominaga, Kentaro Iwasawa, Tzipi Braun, Takanori Takebe, Michael A Helmrath, Yael Haberman, James M Wells, Lee A Denson
    Journal of Crohn's and Colitis.2024;[Epub]     CrossRef
  • How Protein Depletion Balances Thrombosis and Bleeding Risk in the Context of Platelet’s Activatory and Negative Signaling
    Hector Montecino-Garrido, Andrés Trostchansky, Yolanda Espinosa-Parrilla, Iván Palomo, Eduardo Fuentes
    International Journal of Molecular Sciences.2024; 25(18): 10000.     CrossRef
  • Stricturing Crohn’s disease and intestinal endometriosis: An unusual coexistence
    F. Carvajal, F. López, P. Núñez, L. Contreras, R. Quera
    Revista de Gastroenterología de México (English Edition).2024; 89(4): 550.     CrossRef
  • The Versatile Role of Peroxisome Proliferator-Activated Receptors in Immune-Mediated Intestinal Diseases
    Edit Posta, Istvan Fekete, Istvan Varkonyi, Eva Zold, Zsolt Barta
    Cells.2024; 13(20): 1688.     CrossRef
  • Eosinophils mitigate intestinal fibrosis while promoting inflammation in a chronic DSS colitis model and co-culture model with fibroblasts
    Inge Jacobs, Sara Deleu, Bo-Jun Ke, Jonathan Cremer, Ellen Dilissen, Gert De Hertogh, Tobie Martens, Pieter Vanden Berghe, Gianluca Matteoli, Séverine Vermeire, Christine Breynaert, Tim Vanuytsel, Bram Verstockt
    Scientific Reports.2024;[Epub]     CrossRef
  • Endoskopische und chirurgische Behandlung intestinaler Stenosen im Zusammenhang mit chronisch-entzündlichen Darmerkrankungen
    Tabea Pfister, Jonas Zbinden, Benjamin Misselwitz, Emanuel Burri, Florian Rieder, Lukas Brügger, Reiner Wiest
    Schweizer Gastroenterologie.2024;[Epub]     CrossRef
  • Enter the Matrix: Fibroblast-immune cell interactions shape extracellular matrix deposition in health and disease.
    Anthony Altieri, Grace V. Visser, Matthew B. Buechler
    F1000Research.2024; 13: 119.     CrossRef
  • Korean clinical practice guidelines on biologics for moderate to severe Crohn’s disease
    Seong-Joon Koh, Sung Noh Hong, Soo-Kyung Park, Byong Duk Ye, Kyeong Ok Kim, Jeong Eun Shin, Yong Sik Yoon, Hong Sub Lee, Sung Hoon Jung, Miyoung Choi, Soo-Young Na, Chang Hwan Choi, Joo Sung Kim
    Intestinal Research.2023; 21(1): 43.     CrossRef
  • Targeting integrin pathways: mechanisms and advances in therapy
    Xiaocong Pang, Xu He, Zhiwei Qiu, Hanxu Zhang, Ran Xie, Zhiyan Liu, Yanlun Gu, Nan Zhao, Qian Xiang, Yimin Cui
    Signal Transduction and Targeted Therapy.2023;[Epub]     CrossRef
  • Adipokine C1q/Tumor Necrosis Factor- Related Protein 3 (CTRP3) Attenuates Intestinal Inflammation Via Sirtuin 1/NF-κB Signaling
    Huimin Yu, Zixin Zhang, Gangping Li, Yan Feng, Lingling Xian, Fatemeh Bakhsh, Dongqing Xu, Cheng Xu, Tyrus Vong, Bin Wu, Florin M. Selaru, Fengyi Wan, Mark Donowitz, G. William Wong
    Cellular and Molecular Gastroenterology and Hepatology.2023; 15(4): 1000.     CrossRef
  • Burden of disease among patients with prevalent Crohn’s disease: results from a large German sickness fund
    Evi Zhuleku, Beatriz Antolin-Fontes, Andras Borsi, Riikka Nissinen, Ivana Bravatà, Jennifer Norma Barthelmes, Jennifer Lee, Alun Passey, Daniel Wirth, Ulf Maywald, Bernd Bokemeyer, Thomas Wilke, Marco Ghiani
    International Journal of Colorectal Disease.2023;[Epub]     CrossRef
  • Fibro-Stenosing Crohn’s Disease: What Is New and What Is Next?
    Virginia Solitano, Arianna Dal Buono, Roberto Gabbiadini, Marek Wozny, Alessandro Repici, Antonino Spinelli, Stefania Vetrano, Alessandro Armuzzi
    Journal of Clinical Medicine.2023; 12(9): 3052.     CrossRef
  • How to Evaluate Fibrosis in IBD?
    Helena Tavares de Sousa, Fernando Magro
    Diagnostics.2023; 13(13): 2188.     CrossRef
  • Smooth muscle dysfunction in the pre-inflammation site in stenotic Crohn’s-like colitis: implication of mechanical stress in bowel dysfunction in gut inflammation
    John C. Johnson, Ramasatyaveni Geesala, Ke Zhang, You-Min Lin, Amosy E. M’Koma, Xuan-Zheng Shi
    Frontiers in Physiology.2023;[Epub]     CrossRef
  • Risk and incidence of colorectal stricture progressing to colorectal neoplasia in patients with inflammatory bowel disease: a systematic review and meta-analysis
    Yanrong Zhan, Xianwen Cheng, Pingping Mei, Jiyun Wu, Yan Ou, Yaping Cui
    European Journal of Gastroenterology & Hepatology.2023; 35(10): 1075.     CrossRef
  • P2X7 Receptor Regulates Collagen Expression in Human Intestinal Fibroblasts: Relevance in Intestinal Fibrosis
    Lluis Lis-López, Cristina Bauset, Marta Seco-Cervera, Dulce Macias-Ceja, Francisco Navarro, Ángeles Álvarez, Juan Vicente Esplugues, Sara Calatayud, Maria Dolores Barrachina, Dolores Ortiz-Masià, Jesús Cosín-Roger
    International Journal of Molecular Sciences.2023; 24(16): 12936.     CrossRef
  • Solitary lipoma of ileocaecal valve mimicking Crohn's disease: A case report of a challenging diagnosis for a rare benign tumor of the intestinal tract
    Debaibi Mehdi, Talbi Skander, Trigui Racem, Nejib Fatma, Guermazi Ahmed, Chouchen Adnen
    International Journal of Surgery Case Reports.2023; 110: 108696.     CrossRef
  • Role of the epithelial barrier in intestinal fibrosis associated with inflammatory bowel disease: relevance of the epithelial-to mesenchymal transition
    Dulce C. Macias-Ceja, M. Teresa Mendoza-Ballesteros, María Ortega-Albiach, M. Dolores Barrachina, Dolores Ortiz-Masià
    Frontiers in Cell and Developmental Biology.2023;[Epub]     CrossRef
  • Distribution of small bowel involvement and its association with clinical outcomes in patients with Crohn’s disease
    Jin Park, Hae Young Kim, Yoon Jin Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee
    Medicine.2023; 102(40): e35040.     CrossRef
  • Downregulation of Heat Shock Protein 72 Contributes to Fibrostenosis in Crohn’s Disease
    Seung Won Kim, Jae-Young Lee, Han Cheol Lee, Jae Bum Ahn, Ji Hyung Kim, I Seul Park, Jae Hee Cheon, Duk Hwan Kim
    Gut and Liver.2023; 17(6): 905.     CrossRef
  • Association of Circulating Fibrocytes With Fibrostenotic Small Bowel Crohn’s Disease
    Aito Ueno, Humberto B Jijon, Richard Peng, Steven Sparksman, Barbara Mainoli, Alexis Filyk, Yan Li, Stephanie Wilson, Kerri Novak, Remo Panaccione, Simon Hirota, Antoine Dufour, Cathy Lu, Paul L Beck
    Inflammatory Bowel Diseases.2022; 28(2): 246.     CrossRef
  • Revisiting fibrosis in inflammatory bowel disease: the gut thickens
    Silvia D’Alessio, Federica Ungaro, Daniele Noviello, Sara Lovisa, Laurent Peyrin-Biroulet, Silvio Danese
    Nature Reviews Gastroenterology & Hepatology.2022; 19(3): 169.     CrossRef
  • Clinical factors to predict flare-up in patients with inflammatory bowel disease during international air travel: A prospective study
    Jihye Park, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Alaa El-Hussuna
    PLOS ONE.2022; 17(1): e0262571.     CrossRef
  • Diagnosis and Psychotherapeutic Needs by Early Maladaptive Schemas in Patients With Inflammatory Bowel Disease
    Cornelia Rada, Dan Gheonea, Cristian George Ţieranu, Denisa Elena Popa
    Frontiers in Psychology.2022;[Epub]     CrossRef
  • Network Pharmacology-Based Strategy to Identify the Pharmacological Mechanisms of Pulsatilla Decoction against Crohn’s Disease
    Jinguo Liu, Lu Zhang, Zhaojun Wang, Shanshan Chen, Shuyan Feng, Yujin He, Shuo Zhang
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Is radiological healing alone enough? ‘Can’t take my eyes off’ the mucosa
    Su Hyun Park, Sang Hyoung Park
    The Korean Journal of Internal Medicine.2022; 37(3): 551.     CrossRef
  • Intestinal Ultrasound for Differentiating Fibrotic or Inflammatory Stenosis in Crohn’s Disease: A Systematic Review and Meta-analysis
    Chenjing Xu, Wenyu Jiang, Lu Wang, Xiaqiong Mao, Ziping Ye, Hongjie Zhang
    Journal of Crohn's and Colitis.2022; 16(9): 1493.     CrossRef
  • Continued Postoperative Use of Tumor Necrosis Factor-α Inhibitors for the Prevention of Crohn’s Disease Recurrence
    Jongwook Yu, Hye Kyung Hyun, Jihye Park, Eun Ae Kang, Soo Jung Park, Jae Jun Park, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
    Gut and Liver.2022; 16(3): 414.     CrossRef
  • Use of Intraoperative Calibration Spheres for Endoluminal Stricture Assessment to Facilitate Heineke-Mikulicz Strictureplasty in Diffuse Stricturing Crohn’s Jejunoileitis
    Leonardo C. Duraes, Chun Hin Angus Lee, Stefan D. Holubar
    Diseases of the Colon & Rectum.2022; 65(7): e741.     CrossRef
  • Medication Adherence in Korean Patients with Inflammatory Bowel Disease and Its Associated Factors
    Kyunghwan Oh, Eun Ja Kwon, Jeong Hye Kim, Kyuwon Kim, Jae Yong Lee, Hee Seung Hong, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Jeong Yun Park, Sang Hyoung Park
    The Ewha Medical Journal.2022; 45(2): 35.     CrossRef
  • Frequency of Anastomosis Leak in Primary Repair in Ileal Perforation
    Muhammad Shah, Muhammad Iftikhar, Yousaf Jan, Shehzad Akbar Khan, Shimee Shahzadi
    Journal of Gandhara Medical and Dental Science.2022; 9(3): 39.     CrossRef
  • Bowel Preserving Surgery for Diffuse Stricturing Crohn’s Jejunoileitis
    Leonardo C. Duraes, Stefan D. Holubar
    Diseases of the Colon & Rectum.2022;[Epub]     CrossRef
  • Prevention and Treatment of Stricturing Crohn’s Disease – Perspectives and Challenges
    Joseph Sleiman, Sara El Ouali, Taha Qazi, Benjamin Cohen, Scott R. Steele, Mark E. Baker, Florian Rieder
    Expert Review of Gastroenterology & Hepatology.2021; 15(4): 401.     CrossRef
  • Risk factors for rebleeding in Crohn's disease patients with acute severe lower gastrointestinal bleeding: With special reference to the role of anti‐tumor necrosis factor therapy
    Dae Sung Kim, Jiyoung Yoon, Ye‐Jee Kim, Jin Wook Lee, Seung Wook Hong, Ha Won Hwang, Sang Hyoung Park, Dong‐Hoon Yang, Byong Duk Ye, Jeong‐Sik Byeon, Seung‐Jae Myung, Suk‐Kyun Yang
    Journal of Gastroenterology and Hepatology.2021; 36(9): 2455.     CrossRef
  • Crohn’s disease: a population-based study of surgery in the age of biological therapy
    Christian Stöss, Maximilian Berlet, Stefan Reischl, Ulrich Nitsche, Marie-Christin Weber, Helmut Friess, Dirk Wilhelm, Philipp-Alexander Neumann
    International Journal of Colorectal Disease.2021; 36(11): 2419.     CrossRef
  • Novel mechanisms and clinical trial endpoints in intestinal fibrosis*
    Jie Wang, Sinan Lin, Jonathan Mark Brown, David van Wagoner, Claudio Fiocchi, Florian Rieder
    Immunological Reviews.2021; 302(1): 211.     CrossRef
  • Is Paradigm for the Role of Balloon-Assisted Enteroscopy Changing in Crohn’s Disease?
    Yoo Jin Lee
    Gut and Liver.2021; 15(3): 325.     CrossRef
  • Intestinal stricture in Crohn's disease: A 2020 update
    Xiao Xuan Lin, Yun Qiu, Xiao Jun Zhuang, Fen Liu, Xiao Min Wu, Min Hu Chen, Ren Mao
    Journal of Digestive Diseases.2021; 22(7): 390.     CrossRef
  • Medical Management of Aggressive Inflammatory Bowel Disease: When Is the Time to Cut Your (and the Patient's) Losses?
    Jared Sninsky, Edward L. Barnes
    Journal of Laparoendoscopic & Advanced Surgical Techniques.2021; 31(8): 905.     CrossRef
  • Epidemiology and diagnosis of inflammatory bowel diseases
    Kang-Moon Lee
    Journal of the Korean Medical Association.2021; 64(9): 579.     CrossRef
  • Intestinal microbiota and inflammatory bowel diseases
    Chang Soo Eun
    Journal of the Korean Medical Association.2021; 64(9): 588.     CrossRef
  • The Multiple Faces of Integrin–ECM Interactions in Inflammatory Bowel Disease
    Valentina Garlatti, Sara Lovisa, Silvio Danese, Stefania Vetrano
    International Journal of Molecular Sciences.2021; 22(19): 10439.     CrossRef
  • A Novel Cause of Bowel Obstruction in a Patient with Long-Standing Crohn’s Disease
    Satya V. Vedula, T. Paul Nickerson, Douglas J. Grider, Mark Li cheng Wu
    Case Reports in Pathology.2021; 2021: 1.     CrossRef
  • 14,331 View
  • 686 Download
  • 55 Web of Science
  • 59 Crossref
Close layer
Original Articles
Inflammatory bowel diseases
A glycolipid adjuvant, 7DW8-5, provides a protective effect against colonic inflammation in mice by the recruitment of CD1d-restricted natural killer T cells
Chansu Lee, Sung Noh Hong, Young-Ho Kim
Intest Res 2020;18(4):402-411.   Published online April 8, 2020
DOI: https://doi.org/10.5217/ir.2019.00132
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background/Aims
The modulation of CD1d-restricted natural killer T (NKT) cells by glycolipids has been considered as a potential therapy against immunologic diseases, including inflammatory bowel disease. A recently identified a glycolipid analog, 7DW8-5, which is derived from α-galactosylceramide (α-GalCer), is as much as 100-fold more active at stimulating both human and mice NKT cells when compared to α-GalCer. We explored the effects of 7DW8-5 in mouse models of acute and chronic colitis.
Methods
We investigated the effects of 7DW8-5 on intestinal inflammation by assessing the effects of 7dW8-5 on a murine dextran sulfate sodium (DSS)-induced acute colitis model and a chronic colitis-associated tumor model.
Results
The acute DSS-induced colitis model showed a dose-dependent response to 7DW8-5, as mice administered 7DW8-5 showed a significant improvement in DSS-induced colitis based on their disease activity index, histologic analysis, and serum C-reactive protein levels, when compared to mice administered vehicle alone. However, DSS-induced colitis in CD1d-KO mice showed no response to 7DW8-5. A fluorescence-activating cell sorting analysis revealed an increase in NKT cells in colonic tissues of 7DW8-5-treated mice. RNA-seq and real-time quantitative polymerase chain reaction showed a significant increase in the expression of interleukin (IL)-4, IL-13, and interferon-gamma in 7DW8-5-treated mice. In addition, 7DW8-5 treatment reduced colitis-associated tumor development in an azoxymethane/DSS mouse model.
Conclusions
7DW8-5 activates NKT cells through CD1d and provides a protective effect against intestinal inflammation in mice. Therefore, 7DW8-5 may be a promising therapeutic agent for treatment of inflammatory bowel disease.

Citations

Citations to this article as recorded by  
  • Role of CD1d and iNKT cells in regulating intestinal inflammation
    Sung Won Lee, Hyun Jung Park, Luc Van Kaer, Seokmann Hong
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • An immunostimulatory glycolipid that blocks SARS-CoV-2, RSV, and influenza infections in vivo
    Moriya Tsuji, Manoj S. Nair, Kazuya Masuda, Candace Castagna, Zhenlu Chong, Tamarand L. Darling, Kuljeet Seehra, Youngmin Hwang, Ágata Lopes Ribeiro, Geovane Marques Ferreira, Laura Corredor, Jordana Grazziela Alves Coelho-dos-Reis, Yukiko Tsuji, Munemasa
    Nature Communications.2023;[Epub]     CrossRef
  • Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan Extracted from Sargassum fusiforme
    Xiang Li, Shijun Xin, Xiaoqun Zheng, Liqin Lou, Shiqing Ye, Shengkai Li, Qilong Wu, Qingyong Ding, Ling Ji, Chunrong Nan, Yongliang Lou
    Journal of Agricultural and Food Chemistry.2022; 70(30): 9463.     CrossRef
  • Sex-Specific Differences in Cytokine Induction by the Glycolipid Adjuvant 7DW8-5 in Mice
    Felicia N. Watson, Caroline J. Duncombe, Anya C. Kalata, Ethan Conrad, Sumana Chakravarty, B. Kim Lee Sim, Stephen L. Hoffman, Moriya Tsuji, Melanie J. Shears, Sean C. Murphy
    Biomolecules.2022; 13(1): 8.     CrossRef
  • 6,033 View
  • 149 Download
  • 4 Web of Science
  • 4 Crossref
Close layer
Inflammatory bowel diseases
Phenotypic characteristics of pediatric inflammatory bowel disease in Japan: results from a multicenter registry
Katsuhiro Arai, Reiko Kunisaki, Fumihiko Kakuta, Shin-ichiro Hagiwara, Takatsugu Murakoshi, Tadahiro Yanagi, Toshiaki Shimizu, Sawako Kato, Takashi Ishige, Tomoki Aomatsu, Mikihiro Inoue, Takeshi Saito, Itaru Iwama, Hisashi Kawashima, Hideki Kumagai, Hitoshi Tajiri, Naomi Iwata, Takahiro Mochizuki, Atsuko Noguchi, Toshihiko Kashiwabara, Hirotaka Shimizu, Yasuo Suzuki, Yuri Hirano, Takeo Fujiwara
Intest Res 2020;18(4):412-420.   Published online August 18, 2020
DOI: https://doi.org/10.5217/ir.2019.00130
AbstractAbstract PDFPubReaderePub
Background/Aims
There are few published registry studies from Asia on pediatric inflammatory bowel disease (IBD). Registry network data enable comparisons among ethnic groups. This study examined the characteristics of IBD in Japanese children and compared them with those in European children.
Methods
This was a cross-sectional multicenter registry study of newly diagnosed Japanese pediatric IBD patients. The Paris classification was used to categorize IBD features, and results were compared with published EUROKIDS data.
Results
A total of 265 pediatric IBD patients were initially registered, with 22 later excluded for having incomplete demographic data. For the analysis, 91 Crohn’s disease (CD), 146 ulcerative colitis (UC), and 6 IBD-unclassified cases were eligible. For age at diagnosis, 20.9% of CD, 21.9% of UC, and 83.3% of IBD-unclassified cases were diagnosed before age 10 years. For CD location, 18.7%, 13.2%, 64.8%, 47.3%, and 20.9% were classified as involving L1 (ileocecum), L2 (colon), L3 (ileocolon), L4a (esophagus/stomach/duodenum), and L4b (jejunum/proximal ileum), respectively. For UC extent, 76% were classified as E4 (pancolitis). For CD behavior, B1 (non-stricturing/non-penetrating), B2 (stricturing), B3 (penetrating), and B2B3 were seen in 83.5%, 11.0%, 3.3%, and 2.2%, respectively. A comparison between Japanese and European children showed less L2 involvement (13.2% vs. 27.3%, P< 0.01) but more L4a (47.3% vs. 29.6%, P< 0.01) and L3 (64.8% vs. 52.7%, P< 0.05) involvement in Japanese CD children. Pediatric perianal CD was more prevalent in Japanese children (34.1% vs. 9.7%, P< 0.01).
Conclusions
Upper gastrointestinal and perianal CD lesions are more common in Japanese children than in European children.

Citations

Citations to this article as recorded by  
  • Prognosis of pediatric ulcerative colitis after infliximab failure: A multicenter registry‐based cohort study
    Ryusuke Nambu, Takahiro Kudo, Nao Tachibana, Hirotaka Shimizu, Tatsuki Mizuochi, Sawako Kato, Mikihiro Inoue, Hideki Kumagai, Takashi Ishige, Reiko Kunisaki, Atsuko Noguchi, Toshifumi Yodoshi, Shin‐Ichiro Hagiwara, Shigeo Nishimata, Fumihiko Kakuta, Takes
    Journal of Gastroenterology and Hepatology.2024; 39(2): 312.     CrossRef
  • Prevalence of Inflammatory Bowel Disease Unclassified, as Estimated Using the Revised Porto Criteria, among Korean Pediatric Patients with Inflammatory Bowel Disease
    Sung Hee Lee, Minsoo Shin, Seo Hee Kim, Seong Pyo Kim, Hyung-Jin Yoon, Yangsoon Park, Jaemoon Koh, Seak Hee Oh, Jae Sung Ko, Jin Soo Moon, Kyung Mo Kim
    Pediatric Gastroenterology, Hepatology & Nutrition.2024; 27(4): 206.     CrossRef
  • Clinical Efficacy and Future Application of Indigo Naturalis in the Treatment of Ulcerative colitis
    Dianzhen Wu, Qi Huang, Yingbi Xu, Ruiyi Cao, Ming Yang, Jin Xie, Dingkun Zhang
    Journal of Ethnopharmacology.2024; : 118782.     CrossRef
  • Long‐term clinical and endoscopic outcomes of ustekinumab in pediatric Crohn's disease with anti‐tumor necrosis factor failure
    Yoko Yamamoto, Ichiro Takeuchi, Hirotaka Shimizu, Hiroki Fujikawa, Masanori Toda, Eri Miyata, Hiroaki To, Satoru Nagata, Katsuhiro Arai
    Journal of Gastroenterology and Hepatology.2024;[Epub]     CrossRef
  • Validation of the simplified PIBD‐classes criteria: A single‐center retrospective study
    Yoshikazu Miura, Shin‐ichiro Hagiwara, Keinosuke Hizuka, Ryutaro Saura, Ayaha Hata, Takatoshi Maeyama, Yuri Etani
    Pediatrics International.2024;[Epub]     CrossRef
  • Comparison of Clinical Outcomes in Pediatric Patients with Ileocolonic Crohn Disease Treated with Infliximab Versus Adalimumab
    Eliana Fanous, Tal Marshanski, Noa Tal, Manar Matar, Yael Weintraub, Raanan Shamir, Dror S. Shouval
    Journal of Pediatric Gastroenterology & Nutrition.2023; 77(3): 358.     CrossRef
  • Caracterización clínica y terapéutica de una cohorte multicéntrica de pacientes con enfermedad inflamatoria intestinal en Colombia
    Viviana Parra-Izquierdo, Cristian Flórez Sarmiento, Juan Sebastián Frías-Ordoñez, Melquicedec Vargas, Joshua Kock, Natalia Lozano Escobar, Juan Ricardo Márquez
    Gastroenterología y Hepatología.2023; 46(8): 585.     CrossRef
  • Potential of Gut Microbe-Derived Extracellular Vesicles to Differentiate Inflammatory Bowel Disease Patients from Healthy Controls
    Min Heo, Young Soo Park, Hyuk Yoon, Nam-Eun Kim, Kangjin Kim, Cheol Min Shin, Nayoung Kim, Dong Ho Lee
    Gut and Liver.2023; 17(1): 108.     CrossRef
  • Medical management of pediatric inflammatory bowel disease in the Asia‐Pacific region: A position paper by the Asian Pan‐Pacific Society for Pediatric Gastroenterology, Hepatology, and Nutrition (APPSPGHAN) PIBD Working Group
    Way Seah Lee, Katsuhiro Arai, George Alex, Suporn Treepongkaruna, Kyung Mo Kim, Chee Liang Choong, Karen S. C. Mercado, Andy Darma, Anshu Srivastava, Marion M. Aw
    Journal of Gastroenterology and Hepatology.2023; 38(4): 523.     CrossRef
  • Clinical outcome of ulcerative colitis with severe onset in children: a multicenter prospective cohort study
    Ryusuke Nambu, Katsuhiro Arai, Takahiro Kudo, Takatsugu Murakoshi, Reiko Kunisaki, Tatsuki Mizuochi, Sawako Kato, Hideki Kumagai, Mikihiro Inoue, Takashi Ishige, Takeshi Saito, Atsuko Noguchi, Toshifumi Yodoshi, Shin-Ichiro Hagiwara, Naomi Iwata, Shigeo N
    Journal of Gastroenterology.2023; 58(5): 472.     CrossRef
  • Mucosal immune systems of pediatric inflammatory bowel disease: A review
    Takahiro Kudo, Toshiaki Shimizu
    Pediatrics International.2023;[Epub]     CrossRef
  • Clinical and therapeutic characterisation of a multicentre cohort of patients with inflammatory bowel disease in Colombia
    Viviana Parra-Izquierdo, Cristian Flórez Sarmiento, Juan Sebastián Frías-Ordoñez, Melquicedec Vargas, Joshua Kock, Natalia Lozano Escobar, Juan Ricardo Márquez
    Gastroenterología y Hepatología (English Edition).2023; 46(8): 585.     CrossRef
  • Clinical characteristics and nursing diagnoses of pediatric patients hospitalized with inflammatory bowel disease: a single-center retrospective study in South Korea
    Sung-Yoon Jo, Kyung-Sook Bang
    Child Health Nursing Research.2023; 29(3): 218.     CrossRef
  • Clinical Features and Long-Term Outcomes of Paediatric-Onset Inflammatory Bowel Disease in a Population-Based Cohort in the Songpa-Kangdong District of Seoul, Korea
    Sang Hyoung Park, Jong Pil Im, Hyunju Park, Seung Kyu Jeong, Ji Hyun Lee, Kyoung Hoon Rhee, Young-Ho Kim, Sung Noh Hong, Kyung Ho Kim, Seung In Seo, Jae Myung Cha, Sun Yong Park, Joo Sung Kim, Hyuk Yoon, Sung Hoon Kim, Jisun Jang, Jeong Hwan Kim, Seong O
    Journal of Crohn's and Colitis.2022; 16(2): 207.     CrossRef
  • Long-term Disease Course of Crohn’s Disease: Changes in Disease Location, Phenotype, Activities, and Predictive Factors
    Choong Wui Cho, Myung-Won You, Chi Hyuk Oh, Chang Kyun Lee, Sung Kyoung Moon
    Gut and Liver.2022; 16(2): 157.     CrossRef
  • Symptom Improvement of ulceRative colitis after an Induction dose of UStekinumab in Japanese clinical practice (SIRIUS), measured using patient-reported outcomes: a prospective observational study
    Katsuyoshi Matsuoka, Katsumasa Nagano, Shinya Nagasaki, Yoko Murata, Tadakazu Hisamatsu
    BMJ Open.2022; 12(5): e060081.     CrossRef
  • Personalized medicine in inflammatory bowel disease: Perspectives on Asia
    Su Hyun Park, Sang Hyoung Park
    Journal of Gastroenterology and Hepatology.2022; 37(8): 1434.     CrossRef
  • Phenotypic Pattern of Early Versus Later-Onset Pediatric Inflammatory Bowel Disease in a Eurasian Country
    Bilge S. Akkelle, Deniz Ertem, Burcu Volkan, Engin Tutar
    Journal of Pediatric Gastroenterology & Nutrition.2022; 75(4): e61.     CrossRef
  • Clinical features of very early-onset inflammatory bowel disease in Japan: a retrospective single-center study
    Masaaki Usami, Ichiro Takeuchi, Reiko Kyodo, Yuri Hirano, Kosuke Kashiwagi, Hiroki Fujikawa, Hirotaka Shimizu, Toshinao Kawai, Katsuhiro Arai
    Intestinal Research.2022; 20(4): 475.     CrossRef
  • SYSTEMATIC REVIEW AND META - ANALYSIS OF THE FREQUENCY AND RE-CLASSIFICATION TRENDS OF PEDIATRIC INFLAMMATORY BOWEL DISEASE - UNCLASSIFIED
    Rishi BOLIA, Akhil Dhanesh GOEL
    Arquivos de Gastroenterologia.2022; 59(4): 531.     CrossRef
  • Comparison between Pediatric Crohn’s Disease and Ulcerative Colitis at Diagnosis in Korea: Results from a Multicenter, Registry-Based, Inception Cohort Study
    Sowon Park, Ben Kang, Seung Kim, Sujin Choi, Hyo Rim Suh, Eun Sil Kim, Ji Hyung Park, Mi Jin Kim, Yon Ho Choe, Yeoun Joo Lee, Jae Hong Park, Eell Ryoo, Hong Koh, Byung-Ho Choe
    Gut and Liver.2022; 16(6): 921.     CrossRef
  • Epidemiology and diagnosis of inflammatory bowel diseases
    Kang-Moon Lee
    Journal of the Korean Medical Association.2021; 64(9): 579.     CrossRef
  • Very early onset inflammatory bowel disease in a South Asian country where inflammatory bowel disease is emerging: a distinct clinical phenotype from later onset disease
    Rupa Banerjee, Partha Pal, Zaheer Nabi, Upender Shava, Girish Ganesh, D. Nageshwar Reddy
    Intestinal Research.2021; 19(4): 398.     CrossRef
  • Incidentally Detected Asymptomatic Perianal Abscess in an Adolescent during Crohn's Disease Diagnosis: Is Routine Pelvic Imaging Required in Korean Pediatric Patients at Diagnosis?
    Soo Hyun Um, Sang Woo Lee, Ki Hwan Song, So Mi Lee, Byung-Ho Choe, Yoo Min Lee, Ben Kang
    Pediatric Gastroenterology, Hepatology & Nutrition.2021; 24(6): 564.     CrossRef
  • 6,384 View
  • 206 Download
  • 22 Web of Science
  • 24 Crossref
Close layer
Inflammatory bowel diseases
Pathophysiological role of Atg5 in human ulcerative colitis
Razieh Ardali, Nasrin Kazemipour, Saeed Nazifi, Kamran Bagheri Lankarani, Iman Razeghian Jahromi, Masood Sepehrimanesh
Intest Res 2020;18(4):421-429.   Published online May 8, 2020
DOI: https://doi.org/10.5217/ir.2019.00120
AbstractAbstract PDFPubReaderePub
Background/Aims
Ulcerative colitis (UC), along with Crohn’s disease, is one of the main types of inflammatory bowel disease (IBD). On the other hand, deregulated autophagy is involved in many chronic diseases, including IBD. In this study, we aimed to investigate the role of Atg5 and microRNA-181a (miR-181a) in the pathophysiology of UC.
Methods
Colon biopsy, stool, and blood samples of 6 men and 9 women were confirmed for UC. Also, 13 men and 17 women were selected as healthy control (HC). Enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry were used to measure the Atg-5 content of the colon biopsies. Besides, the serum and stool levels of Atg5 were measured using ELISA. Moreover, the total RNA of blood cells was extracted and evaluated for the expression of miR-181a.
Results
We found 1.2 ng/mL versus 0.46 ng/mL, 0.34 ng/mL versus 0.24 ng/mL, and 0.082 ng/mL versus 0.062 ng/mL of Atg5 in stool, intestinal tissue, and serum of UC and HCs, respectively. There was no significant difference in the expression of miR-181a in the blood samples of UC and HCs. Immunohistochemistry showed high positivity without any significant difference between the 2 groups in the quantitative analysis.
Conclusions
The significant difference observed between the stool Atg5 content of the HCs and UC patients may provide new insight into using this protein as a diagnostic biomarker, however, considering the small size of our studied population further studies are needed.

Citations

Citations to this article as recorded by  
  • Pharmacological induction of autophagy reduces inflammation in macrophages by degrading immunoproteasome subunits
    Jiao Zhou, Chunxia Li, Meng Lu, Gaoyue Jiang, Shanze Chen, Huihui Li, Kefeng Lu, Hans-Uwe Simon
    PLOS Biology.2024; 22(3): e3002537.     CrossRef
  • Autophagy: A potential target for natural products in the treatment of ulcerative colitis
    Wei Zhang, Menglong Zou, Jia Fu, Yin Xu, Ying Zhu
    Biomedicine & Pharmacotherapy.2024; 176: 116891.     CrossRef
  • Deficiency of Autophagy-Related Gene 5 in Keratinocytes Leads to Aggravation of Epidermal Damage in 2,4-Dinitrochlorobenzene-Induced Allergic Contact Dermatitis
    Yi-Qun Zhang, Ta Xiao, Chang-Jun Song, Yang-Ying Ke, Xiang Gao, Min Li, Heng Gu, Xu Chen
    International Journal of Dermatology and Venereology.2023; 6(4): 214.     CrossRef
  • Circular RNA HECTD1 Mitigates Ulcerative Colitis by Promoting Enterocyte Autophagy Via miR-182-5p/HuR Axis
    Yan Xu, Yuxi Tian, Fujun Li, Ying Wang, Junwen Yang, Hui Gong, Xiaoping Wan, Miao Ouyang
    Inflammatory Bowel Diseases.2022; 28(2): 273.     CrossRef
  • Personalized medicine in inflammatory bowel disease: Perspectives on Asia
    Su Hyun Park, Sang Hyoung Park
    Journal of Gastroenterology and Hepatology.2022; 37(8): 1434.     CrossRef
  • Management of inflammatory bowel disease beyond tumor necrosis factor inhibitors: novel biologics and small-molecule drugs
    Soo-Young Na, You Sun Kim
    The Korean Journal of Internal Medicine.2022; 37(5): 906.     CrossRef
  • A study on the potential role of autophagy‐related protein 10 as a biomarker for ulcerative colitis
    Fatemeh Abbasi Teshnizi, Nasrin Kazemipour, Saeed Nazifi, Kamran Bagheri Lankarani, Masood Sepehrimanesh, Iman Razeghian Jahromi
    Physiological Reports.2021;[Epub]     CrossRef
  • Regulation of Endoplasmic Reticulum Stress-Autophagy: A Potential Therapeutic Target for Ulcerative Colitis
    Dan Qiao, Ziwei Zhang, Yali Zhang, Qian Chen, Yujun Chen, Yingjue Tang, Xiong Sun, Zhipeng Tang, Yancheng Dai
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • 5,662 View
  • 133 Download
  • 7 Web of Science
  • 8 Crossref
Close layer
Inflammatory bowel diseases
Prevalence and patient awareness of inflammatory bowel disease in Kazakhstan: a cross-sectional study
Jamilya Kaibullayeva, Aliya Ualiyeva, Ainash Oshibayeva, Anar Dushpanova, John K. Marshall
Intest Res 2020;18(4):430-437.   Published online September 29, 2020
DOI: https://doi.org/10.5217/ir.2019.00099
AbstractAbstract PDFPubReaderePub
Background/Aims
There has been a paucity of published data on the epidemiology of inflammatory bowel disease (IBD) in Central Asia and Kazakhstan. Therefore, we aimed to study IBD prevalence and patient awareness among adults in Kazakhstan.
Methods
The cross-sectional study was carried out among subjects of both sexes aged 18 years and older using IBD Alert Questionnaire (CalproQuest), single fecal calprotectin test, and endoscopy with biopsy to verify IBD from January to December 2017, across regions of Kazakhstan. All participants were included in the study after providing informed consent.
Results
Out of 115,556 subjects, there were 128 confirmed IBD cases, in which 36 Crohn’s disease (CD) and 92 ulcerative colitis (UC) cases identified. The age and sex-adjusted IBD prevalence were 113.9 (95% confidence interval [CI], 69.0–158.9) per 100,000 population. The age- and sex-adjusted prevalence for UC were 84.4 (95% CI, 44.8–123.9) and for CD were 29.5 (95% CI, 8.2–50.9) per 100,000 population.
Conclusions
This is the first report on the prevalence of IBD with a verified diagnosis in the Central Asia and could be used to better plan and allocate healthcare resources for IBD management program.

Citations

Citations to this article as recorded by  
  • A review investigating delays in Crohn's disease diagnosis
    Christophe Souaid, Eddy Fares, Paul Primard, Gilles Macaigne, Weam El Hajj, Stephane Nahon
    Clinics and Research in Hepatology and Gastroenterology.2025; 49(1): 102500.     CrossRef
  • Awareness of inflammatory bowel disease among the general population of Al-Baha region, Saudi Arabia
    Turki Alkully, Sarah Taishan, Wafaa Taishan, Lara Alsakka, Njood Alghamdi, Nouf Alghamdi, Mohammed Alghamdi
    Journal of Medicine and Life.2024; 17(2): 164.     CrossRef
  • Capsule endoscopy in Kazakhstan: a multicenter clinical experience
    Sang Jun Sohn, Kanat Batyrbekov, Ainura Galiakbarova, Laura Yerdaliyeva, Jamilya Kaibullayeva, Jeongwoo Ju, Haejin Lee, Yeoun Joo Lee
    Kosin Medical Journal.2024; 39(3): 179.     CrossRef
  • Systematic review with meta‐analysis: Time to diagnosis and the impact of delayed diagnosis on clinical outcomes in inflammatory bowel disease
    Nishani Jayasooriya, Samantha Baillie, Jonathan Blackwell, Alex Bottle, Irene Petersen, Hanna Creese, Sonia Saxena, Richard C. Pollok
    Alimentary Pharmacology & Therapeutics.2023; 57(6): 635.     CrossRef
  • Impact of Sarcopenia on Clinical Course of Inflammatory Bowel Disease in Korea
    Kwangwoo Nam, Jae Yong Lee, Yousun Ko, Kyung Won Kim, Ho-Su Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byoun, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park
    Digestive Diseases and Sciences.2023; 68(6): 2165.     CrossRef
  • Real-world effectiveness and safety of ustekinumab induction therapy for Korean patients with Crohn’s disease: a KASID prospective multicenter study
    Kyunghwan Oh, Hee Seung Hong, Nam Seok Ham, Jungbok Lee, Sang Hyoung Park, Suk-Kyun Yang, Hyuk Yoon, You Sun Kim, Chang Hwan Choi, Byong Duk Ye
    Intestinal Research.2023; 21(1): 137.     CrossRef
  • Obesity and novel management of inflammatory bowel disease
    Jee Hyun Kim, Chang-Myung Oh, Jun Hwan Yoo
    World Journal of Gastroenterology.2023; 29(12): 1779.     CrossRef
  • Bronchoesophageal fistula in a patient with Crohn’s disease receiving anti-tumor necrosis factor therapy
    Kyunghwan Oh, Kee Don Choi, Hyeong Ryul Kim, Tae Sun Shim, Byong Duk Ye, Suk-Kyun Yang, Sang Hyoung Park
    Clinical Endoscopy.2023; 56(2): 239.     CrossRef
  • Evolving Trends and Burden of Inflammatory Bowel Disease in Asia, 1990–2019: A Comprehensive Analysis Based on the Global Burden of Disease Study
    Xuejie Chen, Xin Xiang, Weitong Xia, Xindi Li, Sidan Wang, Shuyu Ye, Li Tian, Lian Zhao, Feiyan Ai, Zhaohua Shen, Kai Nie, Minzi Deng, Xiaoyan Wang
    Journal of Epidemiology and Global Health.2023; 13(4): 725.     CrossRef
  • Combined Endoscopic and Radiologic Healing Is Associated With a Better Prognosis Than Endoscopic Healing Only in Patients With Crohn's Disease Receiving Anti-TNF Therapy
    Kyunghwan Oh, Eun Hye Oh, Soo Min Noh, Seong Ho Park, Nayoung Kim, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
    Clinical and Translational Gastroenterology.2022; 13(1): e00442.     CrossRef
  • Changes in the Long-term Prognosis of Crohn’s Disease between 1986 and 2015: The Population-Based Songpa-Kangdong Inflammatory Bowel Disease Cohort Study
    Byong Duk Ye, Sung Noh Hong, Seung In Seo, Ye-Jee Kim, Jae Myung Cha, Kyoung Hoon Rhee, Hyuk Yoon, Young-Ho Kim, Kyung Ho Kim, Sun Yong Park, Seung Kyu Jeong, Ji Hyun Lee, Hyunju Park, Joo Sung Kim, Jong Pil Im, Sung Hoon Kim, Jisun Jang, Jeong Hwan Kim,
    Gut and Liver.2022; 16(2): 216.     CrossRef
  • Update on the epidemiology of inflammatory bowel disease in Asia: where are we now?
    Sang Hyoung Park
    Intestinal Research.2022; 20(2): 159.     CrossRef
  • Fecal S100A12 is associated with future hospitalization and step-up of medical treatment in patients with Crohn’s disease in clinical remission: a pilot study
    Sun-Ho Lee, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
    Intestinal Research.2022; 20(2): 203.     CrossRef
  • Clinical Course of Hepatitis B Viral Infection in Patients Undergoing Anti-Tumor Necrosis Factor α Therapy for Inflammatory Bowel Disease
    Ji Min Lee, Shu-Chen Wei, Kang-Moon Lee, Byong Duk Ye, Ren Mao, Hyun-Soo Kim, Soo Jung Park, Sang Hyoung Park, Eun Hye Oh, Jong Pil Im, Byung Ik Jang, Dae Bum Kim, Ken Takeuchi
    Gut and Liver.2022; 16(3): 396.     CrossRef
  • Personalized medicine in inflammatory bowel disease: Perspectives on Asia
    Su Hyun Park, Sang Hyoung Park
    Journal of Gastroenterology and Hepatology.2022; 37(8): 1434.     CrossRef
  • Medication Adherence in Korean Patients with Inflammatory Bowel Disease and Its Associated Factors
    Kyunghwan Oh, Eun Ja Kwon, Jeong Hye Kim, Kyuwon Kim, Jae Yong Lee, Hee Seung Hong, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Jeong Yun Park, Sang Hyoung Park
    The Ewha Medical Journal.2022; 45(2): 35.     CrossRef
  • Evaluation of nutritional status using bioelectrical impedance analysis in patients with inflammatory bowel disease
    Seung Hyuk Kim, You Sun Kim, Si Hyeong Lee, Hyun Mi Lee, Won Eui Yoon, Seo Hyun Kim, Hee Jun Myung, Jeong Seop Moon
    Intestinal Research.2022; 20(3): 321.     CrossRef
  • Oral beclomethasone dipropionate as an add-on therapy and response prediction in Korean patients with ulcerative colitis
    Kyuwon Kim, Hee Seung Hong, Kyunghwan Oh, Jae Yong Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye, Sang Hyoung Park
    The Korean Journal of Internal Medicine.2022; 37(6): 1140.     CrossRef
  • Inflammatory bowel disease in Korea: epidemiology and pathophysiology
    Jung Won Lee, Chang Soo Eun
    The Korean Journal of Internal Medicine.2022; 37(5): 885.     CrossRef
  • Management of inflammatory bowel disease beyond tumor necrosis factor inhibitors: novel biologics and small-molecule drugs
    Soo-Young Na, You Sun Kim
    The Korean Journal of Internal Medicine.2022; 37(5): 906.     CrossRef
  • What Are the Different Phenotypes of Inflammatory Bowel Disease in Asia?
    Su Bee Park, Jin Young Yoon, Jae Myung Cha
    Gut and Liver.2022; 16(5): 676.     CrossRef
  • Natural history of inflammatory bowel disease: a comparison between the East and the West
    Eun Mi Song, Suk-Kyun Yang
    Intestinal Research.2022; 20(4): 418.     CrossRef
  • Clinical Features and Long-term Prognosis of Crohn’s Disease in Korea: Results from the Prospective CONNECT Study
    Seung Wook Hong, Byong Duk Ye, Jae Hee Cheon, Ji Hyun Lee, Ja Seol Koo, Byung Ik Jang, Kang-Moon Lee, You Sun Kim, Tae Oh Kim, Jong Pil Im, Geun Am Song, Sung-Ae Jung, Hyun Soo Kim, Dong Il Park, Hyun-Soo Kim, Kyu Chan Huh, Young-Ho Kim, Jae Myung Cha, Ge
    Gut and Liver.2022; 16(6): 907.     CrossRef
  • The epidemiology of inflammatory bowel disease in Asia and Asian immigrants to Western countries
    Satimai Aniwan, Priscila Santiago, Edward V. Loftus, Sang Hyoung Park
    United European Gastroenterology Journal.2022; 10(10): 1063.     CrossRef
  • Public awareness toward inflammatory bowel disease in Saudi Arabia
    Siraj Eid, Saeed Mohammad, Sulafa Noorelahi, Ali Asiri, Abdullah Taha, Ghallah Najee, Abdulkarim Aldukhail, Taif Alenezi, Rajis Aldosari
    International Journal of Medicine in Developing Countries.2021; : 929.     CrossRef
  • The Clinical Features of Inflammatory Bowel Disease in Patients with Obesity
    Seong Kyun Kim, Ho-Su Lee, Beom-Jun Kim, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park, Masanao Nakamura
    Canadian Journal of Gastroenterology and Hepatology.2021; 2021: 1.     CrossRef
  • Optimal Cutoff Level of Fecal Calprotectin for Detecting Small Bowel Inflammation in Crohn's Disease
    Eun Soo Kim
    Gut and Liver.2021; 15(5): 637.     CrossRef
  • Short-term tolerability and effectiveness of methotrexate monotherapy in adult patients with Crohn’s disease: a retrospective study
    Hee Seung Hong, Kyuwon Kim, Kyunghwan Oh, Jae Yong Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park
    Therapeutic Advances in Gastroenterology.2021;[Epub]     CrossRef
  • Epidemiology and diagnosis of inflammatory bowel diseases
    Kang-Moon Lee
    Journal of the Korean Medical Association.2021; 64(9): 579.     CrossRef
  • Risk and characteristics of tuberculosis after anti-tumor necrosis factor therapy for inflammatory bowel disease: a hospital-based cohort study from Korea
    Jae Yong Lee, Kyunghwan Oh, Hee Seung Hong, Kyuwon Kim, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Ho-Su Lee, Kyung-Wook Jo, Sang Hyoung Park
    BMC Gastroenterology.2021;[Epub]     CrossRef
  • Real world practice of medical treatment for moderate and severe inflammatory bowel diseases in Russian Federation, Republic of Belarus and Republic of Kazakhstan: intermediate results of the INTENT study
    O. V. Knyazev, E. A. Belousova, D. I. Abdulganieva, I. V. Gubonina, J. A. Kaibullayeva, Yu. Kh. Marakhouski, E. Yu. Chashkova, M. V. Shapina, O. B. Shchukina, B. B. Gegenava, N. S. Oliferuk
    Almanac of Clinical Medicine.2021; 49(7): 443.     CrossRef
  • The first step to unveil the epidemiology of inflammatory bowel disease in Central Asia
    Seung Wook Hong, Byong Duk Ye
    Intestinal Research.2020; 18(4): 345.     CrossRef
  • Pediatric Ulcerative Colitis in Kazakhstan: First Case Series from Central Asia and Current Clinical Management
    Dimitri Poddighe, Aigerim Telman, Ernas Tuleutayev, Aigul Ibrayeva
    Gastroenterology Insights.2020; 11(2): 27.     CrossRef
  • 5,842 View
  • 131 Download
  • 29 Web of Science
  • 33 Crossref
Close layer
Inflammatory bowel diseases
Advanced neoplasia detection using chromoendoscopy and white light colonoscopy for surveillance in patients with inflammatory bowel disease
Kyeong Ok Kim, Michael V. Chiorean
Intest Res 2020;18(4):438-446.   Published online October 26, 2020
DOI: https://doi.org/10.5217/ir.2019.00090
AbstractAbstract PDFPubReaderePub
Background/Aims
Chromoendoscopy (CE) has been shown to be superior to white light endoscopy (WLE) for neoplasia detection in inflammatory bowel disease (IBD). We aimed to compare the yield of CE and WLE for the detection of overall neoplasia and advanced neoplasia in IBD.
Methods
Patients who underwent surveillance colonoscopy from 1999 to 2017 were identified from our IBD database. CE procedures were compared with their respective WLE controls in a paired comparison, and frequency of all neoplasia, advanced neoplasia, and serrated neoplasia was assessed for both targeted and random biopsies.
Results
A total of 290 procedures performed in 98 individuals were identified with a median follow-up 4 years (median 3 colonoscopies/patient). CE and WLE were performed in 159 and 131 episodes, respectively. CE detected neoplasia in 40.9% of colonoscopies versus 23.7% with WLE (P= 0.002). In addition, CE detected more advanced neoplasia (18.2% vs. 6.1%, P= 0.002) and serrated lesions (14.5% vs. 6.1%, P= 0.022). Significantly fewer samples were obtained per procedure with CE (14.9 ± 9.7 vs. 20.9 ± 11.1, P< 0.001). Cancer was diagnosed in 2 cases.
Conclusions
CE has a higher detection rate than WLE for advanced neoplasia and serrated lesions in patients with IBD under surveillance. Further prospective studies evaluating the impact of CE on decreasing the risk of interval cancer and colectomy in IBD patients are warranted.

Citations

Citations to this article as recorded by  
  • Colorectal cancer screening guidelines for average-risk and high-risk individuals: A systematic review
    Caroline Tanadi, Kevin Tandarto, Maureen Miracle Stella, Kenny Wijaya Sutanto, Mario Steffanus, Riki Tenggara, Muhammad Begawan Bestari
    Romanian Journal of Internal Medicine.2024; 62(2): 101.     CrossRef
  • Factors Affecting Adherence to National Colorectal Cancer Screening: A 12-Year Longitudinal Study Using Multi-Institutional Pooled Data in Korea
    Dae Sung Kim, Jeeyoung Hong, Kihyun Ryu, Sang Hyuk Lee, Hwanhyi Cho, Jehyeong Yu, Jieun Lee, Jong-Yeup Kim
    Journal of Korean Medical Science.2024;[Epub]     CrossRef
  • Feasibility of moxifloxacin and proflavine dual fluorescence imaging for detecting gastrointestinal neoplastic lesions: A prospective study
    Kwangwoo Nam, Noseong Park, Seunghun Lee, Suil Jeon, Jungbin Lee, Seung‐Mo Hong, Sung Wook Hwang, Sang Hyoung Park, Dong‐Hoon Yang, Byong Duk Ye, Jeong‐Sik Byeon, Suk‐Kyun Yang, Jeong Hoon Lee, Do Hoon Kim, Ki Hean Kim, Seung‐Jae Myung
    Lasers in Surgery and Medicine.2023; 55(4): 378.     CrossRef
  • Colorectal Cancer Surveillance in Patients with Inflammatory Bowel Diseases: Chromoendoscopy or Non-Chromoendoscopy, That Is the Question
    Roberto Gabbiadini, Ferdinando D’Amico, Alessandro De Marco, Maria Terrin, Alessandra Zilli, Federica Furfaro, Mariangela Allocca, Gionata Fiorino, Silvio Danese
    Journal of Clinical Medicine.2022; 11(3): 509.     CrossRef
  • Efficacy, safety and tolerability of oral sulphate tablet for bowel preparation in patients with inflammatory bowel disease: A multicentre randomized controlled study
    Kyeong Ok Kim, Eun Young Kim, Yoo Jin Lee, Hyun Seok Lee, Eun Soo Kim, Yun Jin Chung, Byung Ik Jang, Sung Kook Kim, Chang Heon Yang
    Journal of Crohn's and Colitis.2022; 16(11): 1706.     CrossRef
  • Endoscopic activity in inflammatory bowel disease: clinical significance and application in practice
    Kyeong Ok Kim
    Clinical Endoscopy.2022; 55(4): 480.     CrossRef
  • Image-Enhanced Endoscopy in the Surveillance of Colitis-Associated Neoplasia
    Olga Maria Nardone, Marietta Iacucci
    Gastrointestinal Endoscopy Clinics of North America.2022; 32(4): 845.     CrossRef
  • Active Assessment of Inflammatory Bowel Disease
    金良 肖
    Advances in Clinical Medicine.2022; 12(12): 11023.     CrossRef
  • Chromoendoskopie – Alles, was man wissen muss
    Lisa Amsberg, Ulrike Schempf, Dörte Wichmann
    Endo-Praxis.2022; 38(04): 169.     CrossRef
  • Underutilization of societal guidelines: occasional or widespread?
    Richard Kozarek
    Endoscopy International Open.2021; 09(07): E986.     CrossRef
  • 5,253 View
  • 100 Download
  • 7 Web of Science
  • 10 Crossref
Close layer
Inflammatory bowel diseases
An assessment of dietary intake, food avoidance and food beliefs in patients with ulcerative colitis of different disease status
Nor Hamizah Shafiee, Zahara Abdul Manaf, Norfilza M. Mokhtar, Raja Affendi Raja Ali
Intest Res 2020;18(4):447-458.   Published online June 2, 2020
DOI: https://doi.org/10.5217/ir.2019.00042
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background/Aims
Ulcerative colitis (UC) is a chronic, relapsing and remitting inflammation of the gastrointestinal tract. Little is known about the link between dietary intake, food avoidance, and beliefs among UC patients of different disease severity. Therefore, this study aimed to assess the dietary intake, food avoidance, and beliefs among active and inactive UC patients.
Methods
A cross-sectional study was conducted among UC patients from a tertiary medical center in Kuala Lumpur, Malaysia. Demographic, anthropometric, dietary intake, food avoidance and beliefs were assessed. Disease activity of UC patients was evaluated using the Powell Tuck Index.
Results
UC patients were recruited (64.1% inactive UC and 35.9% active UC). As compared to inactive UC patients, active UC patients were likely to lose weight (75.0% vs. 0%), possess certain food beliefs (95.7% vs. 39.0%), and frequently practiced dietary avoidance (95.7% vs. 43.9%). The dietary intake among inactive UC patients was higher than active UC patients. However, neither of them met the standard nutrients recommendation for protein, calcium, iron, folate, zinc, vitamin D, vitamin B12, and vitamin E.
Conclusions
Active UC patients had poorer dietary intake, were more prone to practicing food avoidance and exhibited certain food beliefs as compared to inactive UC patients. Both macro- and micronutrients intakes were inadequate regardless of patient’s disease status. These findings emphasized the importance for patients to be provided with the nutrition-related knowledge as part of strategies to avoid nutritional inadequacies.

Citations

Citations to this article as recorded by  
  • Analysis of the Nutritional Value of Diets and Food Choices in Polish Female Ulcerative Colitis Individuals Compared with a Pair-Matched Control Sample
    Dominika Głąbska, Dominika Guzek, Gustaw Lech
    Nutrients.2023; 15(4): 857.     CrossRef
  • Mobile-based program improves healthy eating of ulcerative colitis patients: A pilot study
    Wenjing Tu, Shuxia Yan, Tingting Yin, Sumin Zhang, Wenjing Xu, Ping Zhang, Guihua Xu
    DIGITAL HEALTH.2023;[Epub]     CrossRef
  • Self‐reported flares among people living with inflammatory bowel disease are associated with stress and worry but not associated with recent diet changes: The Manitoba Living with IBD Study
    Kathy Vagianos, Leigh Anne Shafer, Kelcie Witges, Lesley A. Graff, Laura E. Targownik, Charles N. Bernstein
    Journal of Parenteral and Enteral Nutrition.2022; 46(7): 1686.     CrossRef
  • Evaluation of nutritional status using bioelectrical impedance analysis in patients with inflammatory bowel disease
    Seung Hyuk Kim, You Sun Kim, Si Hyeong Lee, Hyun Mi Lee, Won Eui Yoon, Seo Hyun Kim, Hee Jun Myung, Jeong Seop Moon
    Intestinal Research.2022; 20(3): 321.     CrossRef
  • Dietary beliefs and information resources of ulcerative colitis patients in clinical remission: A cross-sectional survey in Taiwan
    Cheng-Tzu Hsieh, Meng-Tzu Weng, Chien-Chih Tung, Nai-Chia Chen, Hui-Chuen Chen, Kuo-Liong Chien, Shu-Chen Wei
    Clinical Nutrition ESPEN.2022; 51: 430.     CrossRef
  • Micronutrient deficiency among patients with ulcerative colitis
    Amany Hussien, Sawsan Abd El-Moniem, Ziyad Tawhid, Ahmed Altonbary
    The Egyptian Journal of Internal Medicine.2022;[Epub]     CrossRef
  • 6,688 View
  • 147 Download
  • 6 Web of Science
  • 6 Crossref
Close layer
Functional bowel disorders
Psychological profiles of irritable bowel syndrome patients with different phenotypes
Michel Bouchoucha, Ghislain Devroede, Noëlle Girault-Lidvan, Maria Hejnar, Florence Mary, Robert Benamouzig
Intest Res 2020;18(4):459-468.   Published online October 26, 2020
DOI: https://doi.org/10.5217/ir.2019.09171
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background/Aims
Abnormal psychological profiles are frequently found in patients with functional gastrointestinal disorders (FGIDs). The present study aimed to evaluate the psychological profiles of FGID patients with irritable bowel syndrome (IBS), and IBS phenotypes.
Methods
In 608 FGID patients, including 235 with IBS, have filled a Rome III questionnaire and the French version of the Minnesota Multiphasic Personality Inventory 2. Data analysis was performed using univariate analysis and multivariate logistic regression.
Results
This study shows that IBS patients have abnormal psychological profiles with more significant symptom exaggeration and decreased test defensiveness than non-IBS patients. They have a significantly higher score for all clinical scales. Logistic regression analysis showed in IBS patients a decrease of body mass index (P= 0.002), and test defensiveness score K (P= 0.001) and an increase of Hypochondriasis (P< 0.001) and Masculinity-Femininity scale (P= 0.018). By comparison with non-IBS patients, IBS-constipation, IBS-diarrhea, and mixed IBS patients have increased Hypochondriasis value and Depression score, mixed IBS patients have higher Psychasthenia score and higher Hypomania score. No item was significantly different in the IBS-unspecified group.
Conclusions
This study shows that IBS patients have different psychological profiles than other FGID patients and that psychological characteristics are associated with IBS phenotypes except for patients with unsubtyped IBS.

Citations

Citations to this article as recorded by  
  • Psychopathology and the Validity of Gastrointestinal Symptom Reporting as Revealed Through Cluster Analyses of MMPI-2-RF Results
    Paris A. Lang, Linda Thomas, Brett A. Lidbury
    Digestive Diseases and Sciences.2024; 69(11): 4063.     CrossRef
  • The role of psychological factors in functional gastrointestinal disorders: a systematic review and meta-analysis
    Liyanran Yan, Xueli Zhang, Yan Li, Chengjiang Liu, Hua Yang, Chunchun Yang
    International Journal of Colorectal Disease.2023;[Epub]     CrossRef
  • An Asian perspective on irritable bowel syndrome
    Kee Wook Jung, Seung-Jae Myung
    Intestinal Research.2023; 21(2): 189.     CrossRef
  • Limited evidence of moderation of the association between gastrointestinal symptoms and prospective healthcare utilisation by quality of life
    David T. McNaughton, Anna Andreasson, Brjánn Ljótsson, Alissa P. Beath, Julia M. Hush, Gunnar Ljunggren, Peter T. Schmidt, Nicholas J. Talley, Lars Agréus, Michael P. Jones
    Alimentary Pharmacology & Therapeutics.2022; 55(3): 311.     CrossRef
  • Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Trial
    Seung Yong Shin, Sein Park, Jung Min Moon, Kisung Kim, Jeong Wook Kim, Jongsik Chun, Tae Hee Lee, Chang Hwan Choi
    Journal of Neurogastroenterology and Motility.2022; 28(4): 642.     CrossRef
  • Psychopathological and neuropsychological disorders associated with chronic primary visceral pain: Systematic review
    Alejandro Arévalo-Martínez, Juan Manuel Moreno-Manso, María Elena García-Baamonde, Macarena Blázquez-Alonso, Pilar Cantillo-Cordero
    Frontiers in Psychology.2022;[Epub]     CrossRef
  • Impact of Psychological Comorbidity on the Prognosis of Irritable Bowel Syndrome
    Vivek C. Goodoory, Antonina Mikocka-Walus, Yan Yiannakou, Lesley A. Houghton, Christopher J. Black, Alexander C. Ford
    American Journal of Gastroenterology.2021; 116(7): 1485.     CrossRef
  • 17,977 View
  • 123 Download
  • 8 Web of Science
  • 7 Crossref
Close layer
Case Report
Inflammatory bowel diseases
Long-term outcome after surgery in a patient with intestinal Behçet’s disease complicated by myelodysplastic syndrome and trisomy 8
Yuki Mori, Fumihiko Iwamoto, Yasuaki Ishida, Toru Kuno, Shoji Kobayashi, Takashi Yoshida, Tatsuya Yamaguchi, Tadashi Sato, Makoto Sudo, Daisuke Ichikawa, Nobuyuki Enomoto
Intest Res 2020;18(4):469-475.   Published online May 12, 2020
DOI: https://doi.org/10.5217/ir.2019.09141
AbstractAbstract PDFPubReaderePub
Behçet’s disease (BD) is a multisystem inflammatory disease of unknown origin. Rarely, BD occurs together with myelodysplastic syndrome (MDS). Interestingly, it is speculated that these are not simple coexistence but that the etiology of intestinal BD is at least partly derived from MDS itself. Furthermore, there is a relationship between MDS in patients with intestinal BD and trisomy 8. Immunosuppressive agents alone are insufficient to control MDS-associated BD, and many of these patients die of infection or hemorrhage. Surgery is considered for intestinal BD patients who are unresponsive to medical treatment or those with bowel complications such as perforation or persistent bleeding. We report a case of intestinal BD associated with MDS and trisomy 8. The patient was unresponsive to oral steroids and immunosuppressive treatment; the patient improved by surgical repair of a bowel perforation. Five years after the surgery, the patient is free of recurrence and not on medication. Our experience suggests that surgery may provide an effective therapeutic option for the treatment of MDS-related BD.

Citations

Citations to this article as recorded by  
  • Optimal Treatment Approaches to Intestinal Behçet's Disease Complicated by Myelodysplastic Syndrome: The KASID and KSBD Multicenter Study
    Jung-Bin Park, So Jung Han, Seung Bum Lee, Dong Hyun Kim, Jae Hee Cheon, Sung Wook Hwang, Byong Duk Ye, Suk-Kyun Yang, Soo Jung Park, Sang Hyoung Park
    Yonsei Medical Journal.2024; 65(5): 265.     CrossRef
  • Long‐term clinical outcomes of intestinal Behçet's disease: A 30‐year cohort study at a tertiary hospital in South Korea
    Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Hee Cheon
    Journal of Gastroenterology and Hepatology.2023; 38(3): 386.     CrossRef
  • Interplay between chronic inflammation and clonal haematopoiesis of indeterminate potential in Behçet’s disease
    Jihye Park, Hongyul An, Jiwoo Lim, I Seul Park, Mi Hyun Kim, Ji Hyung Kim, Seung Won Kim, Young Il Koh, Eun Young Lee, Jae Hee Cheon
    Arthritis Research & Therapy.2023;[Epub]     CrossRef
  • Real-world effectiveness and safety of adalimumab in Korean patients with intestinal Behcet’s disease: a Korean Association for the Study of Intestinal Diseases (KASID) multicenter study
    Seung Bum Lee, Hee Seung Hong, Chang Kyun Lee, Bo-In Lee, Sol Kim, Seong-Joon Koh, Hosun Yu, Jung-Bin Park, Sung Wook Hwang, Byong Duk Ye, Suk-Kyun Yang, Sang Hyoung Park
    The Korean Journal of Internal Medicine.2023; 38(5): 661.     CrossRef
  • Effectiveness and safety of adalimumab in patients with intestinal Behçet’s disease: a real-world prospective observational study in South Korea
    Jongwook Yu, Sung Jae Shin, Yune-Jung Park, Hyung Wook Kim, Bo-In Lee, Byong Duk Ye, Geun-Tae Kim, Sung Kook Kim, Joo Sung Kim, Young-Ho Kim, Seonjeong Jeong, Jae Hee Cheon
    BMC Gastroenterology.2023;[Epub]     CrossRef
  • Trisomy 8-positive Polycythemia Vera Complicated with Intestinal Behçet's-like Disease: A New Perspective for a Clinical Approach
    Yuki Mori, Fumihiko Iwamoto, Toru Kuno, Shoji Kobayashi, Takashi Yoshida, Tatsuya Yamaguchi, Shinichi Takano, Tetsuo Kondo, Keita Kirito, Nobuyuki Enomoto
    Internal Medicine.2022; 61(11): 1713.     CrossRef
  • Clinical Course of Patients with Intestinal Behçet’s Disease According to Consensus-Based Diagnostic Categories
    Yu Young Joo, Bo-In Lee, Seung-Jun Kim, Han Hee Lee, Jin Su Kim, Jae Myung Park, Young-Seok Cho, Kang Moon Lee, Sang Woo Kim, Hwang Choi, Myung-Gyu Choi
    Gut and Liver.2022; 16(5): 746.     CrossRef
  • 5,603 View
  • 167 Download
  • 7 Web of Science
  • 7 Crossref
Close layer

Intest Res : Intestinal Research
Close layer
TOP