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Volume 2(1); April 2004
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Reviews
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Clinical Usage of Probiotics and Its Mechanism of Action
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Dong Soo Han, Joon Yong Park
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Intest Res 2004;2(1):5-10. Published online April 16, 2004
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Abstract
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- Probiotics has been prescribed for various medical purposes. The benefit of using probiotics has been clarified in antibiotics associated diarrhea, travelers' diarrhea, acute diarrhea, diarrhea in the pediatric field, functional diarrhea and some part of inflammatory bowel disease. However, the mechanism of action of probiotics is still in the investigation. Its functions of excreting bacterial products, adhesion to bowel wall, competition with other bacteria, and promoting mucin secretion from bowel mucosa have been discussed as the mechanism of action of probiotics. Recently the immune modulation of probiotics started to be regarded as the main part of its mechanism of action. Probiotics may produce its immune modulation by modifying the activation of Toll-like receptor: the main receptor of inducing innate immunity. (Intestinal Research 2004;2:5-10)
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Post-infectious Irritable Bowel Syndrome
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Young Soo Park, Dong Ho Lee
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Intest Res 2004;2(1):11-14. Published online April 16, 2004
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Original Articles
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Clinical Usefulness of Telomerase and hTERT for the Detection of Colon Cancer in Ulcerative Colitis
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Kyu-Jong Kim, Seung-Jae Myung, Seong Soo Hong, Sun-Mi Lee Lee, Jeong-Sik Byeon, Suk-Kyun Yang, Weon-Seon Hong, Jin-Ho Kim, Young Il Min
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Intest Res 2004;2(1):15-20. Published online April 16, 2004
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Abstract
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- Background/Aims
Telomerase and telomerase reverse transcriptase (hTERT), are specifically expressed in cancer cells, making them candidate markers for the early detection of cancer. The aims of our study were to determine whether these assays may be useful in the diagnosis of colorectal cancer (CRC) developed in ulcerative colitis (UC) patients. Methods: Luminal washings and biopsies were collected during colonoscopy in 66 patients; 34 with CRC, 21 with UC, and 11 controls. Telomerase activity was detected by telomeric repeat amplification protocol (TRAP) and hTERT was assayed by RT-PCR. Results: Telomerase activity was detected in biopsies from 33/34 (97%) CRC, 14/21 (67%) UC, and 3/11 (27%) controls. hTERT was positive in biopsies from 32/34 (94%) CRC, 12/21 (57%) UC, and 5/11 (45%) controls. In washing fluid, 21/34 (62%) of CRC patients were positive for telomerase, but UC patients and controls were negative. The sensitivity of telomerase for CRC was 97% in tissues and 62% in washing fluid. The specificity of telomerase in washing fluid was 100%, whereas the specificity of telomerase or hTERT mRNA in tissues was 47% each. Conclusions: The low specificity of telomerase and hTERT in colonic tissue suggest that these are not candidate markers for CRC arising in UC. Telomerase in colonoscopic luminal washings, however, may be a novel marker for early CRC in UC. (Intestinal Research 2004;2:15-20)
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Clinical Review about Colon Perforation Complicated Diagnostic or Therapeutic Colonoscopy
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Song Won Jung, Chang Beom Ryu, Yon Soo Kim, Min Soo Song, Bong Min Ko, Sang Woo Cha, Kwon Ho You, Soo Jin Hong, Young Seok Kim, Jong Ho Moon, Moon Sung Lee, Chan Sup Shim, Boo Sung Kim
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Intest Res 2004;2(1):21-25. Published online April 16, 2004
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Abstract
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- Colonoscopy is used increasingly because the indication for therapeutic colonoscopy has been increased and the technique has been developed continuously as well as colonosopy is useful for diagnosis of colonic disease. Therefore, It is important understanding precisely about the complication of colonoscopy and managing the complication immediately and properly. In particular, colon perforation is the most fatal, emergency case and have needed surgical treatment, generally. Recently, the case treated with endoscopic clipping and conservative management has been reported. but until now, when perforated, wheather the endoscopic clipping or the surgical management at each other case is beneficial is not confirmed. (Intestinal Research 2004;2:21-25)
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The Influence of Inflammatory Bowel Disease and Its Treatment with 5-Aminosalicylic Acid on Pregnancy and Fetal Outcome
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Ji Hun Choi, Hye Seung Yoo, Suk-Kyun Yang, Seung-Jae Myung, Yun Kyung Cho, Yun-Jung Lee, Jeong-Sik Byeon, Gin Hyug Lee, Hwoon-Yong Jung, Weon-Seon Hong, Jin-Ho Kim, Young Il Min
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Intest Res 2004;2(1):26-30. Published online April 16, 2004
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Abstract
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- Background/Aims
5-Aminosalicylic acid (5-ASA) preparations are the first-line drugs in the treatment of inflammatory bowel disease (IBD). The aim of this study was to examine the influence of IBD and its treatment with 5-ASA on pregnancy and fetal outcome. Methods: A total of 56 patients (ulcerative colitis 41, Crohn's disease 15) experienced 84 pregnancies among 634 female patients with IBD between June 1989 and August 2003. The outcomes of 42 pregnancies exposed to 5-ASA during pregnancy were compared with those of 42 non-exposed pregnancies. Results: Pregnancy outcomes were not different between the exposed and non-exposed pregnancies in terms of live birth (85.7% vs 80.9%), abortion (11.9% vs 19.0%), stillbirth (2.4% vs 0%), preterm delivery (11.1% vs 5.9%), low birth weight (11.1% vs 8.8%), congenital malformation (2.8% vs 2.9%), and aggravation of disease during pregnancy (21.4% vs 16.7%). These figures appear to be similar to those of general population. Conclusions: Neither ulcerative colitis nor Crohn's disease has any significant impact on pregnancy outcome, and 5-ASA does not increase the risk of congenital malformation. (Intestinal Research 2004;2:26-30)
Case Reports
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Two Cases of Desmoid Tumor After the Total Colectomy in FAP Patients
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Bo Young Hwang, Hyo Jong Kim, Jae Young Chang, Nam Hoon Kim, Sang Kil Lee, Kwnag Ro Joo, Seok Ho Dong, Joung Il Lee, Byung Ho Kim, Young Woon Chang, Rin Chang
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Intest Res 2004;2(1):31-35. Published online April 16, 2004
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Abstract
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- Desmoid tumors (DT) are rare and slow-growing tumor that consist of proliferation of well-differentiated fibroblast. Although the typical characteristics of malignant tumors, such as distant metastasis, are absent, the tumor are locally aggressive and grow into neighbouring structures and have a high propensity for recurrence after surgical resection. Surgical trauma, genetic predisposition and hormonal factors are considered to be correlated with the development and growth of DT. The prevalence of desmoid tumors in patients with familial adenomatous polyposis (FAP) is 7-12%. The lifetime risk of developing desmoid tumors is about 20%. Inpatients with FAP, desmoids often appear after total colectomy as descrete masses in surgical scars of the abdominal wall or as infiltrating fibroblast sheets within the abdominal mesentery or retroperitoneum. Intra-abdominal or mesenteric desmoids pose a serious management problem because of their propensity to surroud and compress major blood vessels and viscera. Next to colorectal cancer, desmoid tumors are the most frequent cause of death in FAP. There are no standard medical approaches. Recently we experienced two cases of desmoid tumor associated with FAP after total colectomy. One case treated with non steroidal anti-inflammatory drug (NSAID) and tamoxifen, the other with combination chemotherpy. We report comparision of two cases with review of the literatures. (Intestinal Research 2004;2:31-35)
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A Case of Large Polypoid Arteriovenous Malformation of Colon Treated with Detachable Snare
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Jeong Seon Ji, Bo In Lee, Byung Wook Kim, Hwang M.D., Se Hyun Cho, Kyu Yong Choi, Woo Chul Chung, Kang Moon Lee, Hyun Suk Chae, In Sik Chung, Kyong Mee Kim
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Intest Res 2004;2(1):36-39. Published online April 16, 2004
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Abstract
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- Arteriovenous malformation is well known cause of lower gastrointestinal bleeding in elderly patients. This is relatively uncommon in people younger than 50 years of age. Endoscopically, it generally appears as bright red flat or elevated bright red lesion. A polypoid appearance is extremely uncommon. We report a case of large polypoid arteriovenous malformation of colon in 81-year-old male patient. He has complained of hematochezia for 4 days. During colonoscopy, a 3.5 cm sized semipedunculated polypoid mass in the proximal transverse colon was detected. For prevention of bleeding, detachable snare was applied and biopsy was done. 3 days later, follow up colonoscopy was done. There was no hemorrhege. We performed endoscopic mucosal resection. Polypoid arteriovenous malformation of colon was comfirmed by microscopic findings. Histologically, section of excised polyp shows ulceration, hemorrhage and the dilated, irregularly thick walled blood vessels in the mucosa and submucosa. (Intestinal Research 2004;2:36-39)
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A Case of Small Bowel Bleeding not Being Found by Capsule Endoscopy
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Myung Ryul Lee, Hyo Jong Kim, Sang Kil Lee, Nam Hoon Kim, Jae Young Chang, Kwang Ro Joo, Seok Ho Dong, Byung-Ho Kim, Young Woon Chang, Joung Il Lee, Rin Chang
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Intest Res 2004;2(1):40-42. Published online April 16, 2004
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- Diagnostic tool for the study of patients with obscure gastrointestinal bleeding is not confirmed. Recently,capsule endoscopy was used to the effective diagnostic tool for patients with obscure gastrointestinaI bleeding, and was well tolerated and better accepted by patient. But the diagnostic result of this technique has not been adequately studied. We reported a case of finding small bowel beeding due to intraoperative endoscopy with negative capsule endoscopic result. (Intestinal Research 2004;2:40-42)
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A Case of NSAIDs Induced Small Bowel Ulcer Diagnosed by Capsule Endoscopy
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Jae Il Park, Dong Soo Han, Hang Lak Lee, Jin Bae Kim, Jong Pyo Kim, Joo Hyun Sohn, Joon Soo Hahm, Gyung Jo Kim
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Intest Res 2004;2(1):43-45. Published online April 16, 2004
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Abstract
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- The current prevalence of obscure bleeding among all cases of gastrointestinal bleeding was about 5%, most often the site of hemorrhage is suspected to be the small bowel. Bleeding sites located in the small bowel are difficult to detect with conventional radiological methods. Also, endoscopic examination of the small bowel is limited by its significant length and distance from accessible orifices. Nowadays, capsule endoscopy has been developed to facilitate examination of small bowel disorders, including gastrointestinal bleeding. We report a case of NSAIDs induced small bowel ulcer bleeding diagnosed by capsule endoscopy. (Intestinal Research 2004;2:43-45)
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Letter to the Editor
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Intest Res 2004;2(1):46-46. Published online April 16, 2004
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Abstract
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- No abstract available
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Letter to the Editor
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Intest Res 2004;2(1):47-48. Published online April 16, 2004
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Abstract
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- No abstract available
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