Intestinal Research

Effect of Probiotics on Intestinal Infections: Shigeru Kamiya; Intest Res 2011;9(3):171-178. Published online December 30, 2011; DOI: https://doi.org/10.5217/ir.2011.9.3.171

Probiotics are defined as live microorganisms that confer a health benefit on the host when consumed in adequate amounts, such as Lactobacillus, Streptococcus, Enterococcus, Lactococcus, Bifidobacterium, Bacillus, Clostridium, Saccharomyces, Aspergillus, and Escherichia coli species. Previous studies have reported beneficial effects of probiotics on intestinal infections, including Clostridium difficile antibiotic-associated diarrhea, rotavirus infection, traveler's diarrhea, and other bacterial enteric diseases. Although few studies have reported serious adverse effects from probiotics, more evidence-based research is required for an in-depth evaluation of probiotics in medical science. (Intest Res 2011;9:171-178)

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The Challenges of Eradicating Pediatric Helicobacter pylori Infection in the Era of Probiotics
Lorena Elena Meliț, Cristina Oana Mărginean, Maria Oana Săsăran
Children.2022; 9(6): 795. CrossRef
The effect of probiotics on bowel movement and metabolic parameters in schizophrenia patients: a retrospective chart review
Takahiko NAGAMINE, Masaru NAKAMURA
Bioscience of Microbiota, Food and Health.2020; 39(4): 197. CrossRef

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Dose Endoscopic Ultrasonography Impact Diagnosis of Intestinal Diseases?: Qi Zhu, Chao Xu, Duanmin Hu; Intest Res 2011;9(3):179-188. Published online December 30, 2011; DOI: https://doi.org/10.5217/ir.2011.9.3.179

Abstract PDF

Substantial development in equipment such as miniprobe endosonography and enteroscopy has made it possible to use endoscopic ultrasonography (EUS) to detect any part of the digestive tract. EUS plays a vital role in evaluating a lower intestinal malignancy, particularly rectal cancer, to determine whether the disease is localized (T1-2, N0) and appropriate for surgery or locally advanced (T any, N1-2) and would benefit from preoperative neoadjuvant chemoradiation. Moreover, follow-up by EUS may contribute to early recognition of focal tumor recurrence, particularly for lesions that cannot be detected by other imaging modalities. EUS is also an invaluable modality for diagnosing intestinal submucosal tumors, such as gastrointestinal stromal tumors, lipomas, lymphangiomas, leiomyomas, carcinoids, and others such as intestinal endometriosis. Although a definite diagnosis of a submucosal tumor is generally confirmed by cytology or histology results, EUS-guided fine needle aspiration or core biopsy is a fairly helpful practice. EUS is also useful for discriminating between Crohn's disease and ulcerative colitis as well as assessing disease severity. Moreover, it has emerged as a powerful imaging tool to manage perianorectal diseases. EUS also has the potential to be useful for intra-small intestinal ultrasonography for the diagnosis of small bowel diseases in the future. (Intest Res 2011;9:179-188)

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The Clinical Usefulness of Endoscopic Ultrasound-Guided Fine Needle Aspiration and Biopsy for Rectal and Perirectal Lesions
Jae Seung Soh, Ho-Su Lee, Seohyun Lee, Jungho Bae, Hyo Jeong Lee, Sang Hyoung Park, Dong-Hoon Yang, Kyung-Jo Kim, Byong Duk Ye, Seung-Jae Myung, Suk-Kyun Yang, Jin-Ho Kim, Jeong-Sik Byeon
Intestinal Research.2015; 13(2): 135. CrossRef
Application of Endoscopic Ultrasonography in the Diagnosis and Treatment of Lower Gastrointestinal Disease
Eun Young Kim
Intestinal Research.2015; 13(2): 101. CrossRef

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Comparison of Infliximab and Infliximab/Azathioprine for Maintenance Therapy in Korean Patients with Luminal Crohn's Disease: Hyun Sun Won, Dong Il Park, Chang Uk Chon, Hyo Sun Seok, Tae Wan Kim, Woon Je Heo, Chang Kyun Lee, Chang Soo Eun, Dong Soo Han, Suck-Ho Lee; Intest Res 2011;9(3):189-195. Published online December 30, 2011; DOI: https://doi.org/10.5217/ir.2011.9.3.189

Abstract PDF

Background/Aims
The benefits and risks of concomitant immunomodulators with infliximab maintenance therapy in patients with luminal Crohn's disease (CD) have not been adequately evaluated. We studied the influence of immunomodulator discontinuation in patients in remission with infliximab therapy through a restrospective case- control study. Methods: Medical records of 37 patients with luminal CD who received infliximab at four medical centers were retrospectively analyzed. We compared clinical and follow-up data of patients who were treated with infliximab alone with that of patients with combination therapy. Results: Among 37 patients, 31 (83.7%) were treated with infliximab plus azathioprine and six (16.2%) were treated with infliximab alone. Of the 31 patients receiving combination maintenance therapy, 26 (83.9%) were in complete remission after 12 months, as compared with five of six patients (83.3%) receiving infliximab alone. No significant difference was observed in remission rate between two groups (P=0.735). In total, 16.1% of patients in combination therapy and 16.7% in infliximab alone group reported side effects (P=1.000), but serious adverse events such as reactivation of tuberculosis were noted in only one patient in combination therapy group. Conclusions: Concomitant immunomodulators did not improve efficacy in patients with luminal CD who received scheduled infliximab maintenance. (Intest Res 2011;9:189-195)

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Clinical Outcome of Treatment with Infliximab in Crohn's Disease: A Single-Center Experience
Yeon-Ju Kim, Jung-Wook Kim, Chang Kyun Lee, Hyun Jin Park, Jae-Jun Shim, Jae Young Jang, Suk Ho Dong, Hyo Jong Kim, Byung-Ho Kim, Young Woon Chang
The Korean Journal of Gastroenterology.2013; 61(5): 270. CrossRef

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A Korean National Survey for Treatment Modality in Colon Polypectomy: Sung Jae Shin, Suck-Ho Lee, Dong Il Park, Sung Noh Hong, Seong-Eun Kim, Dong-Hoon Yang, Sung Pil Hong, Bo In Lee, Hyun Soo Kim, Young-Ho Kim, Suk-Kyun Yang, Hyo Jong Kim, Se Hyung Kim, Multi-Society Task Force for the Guidelines for Colorectal Polyp Screening, Surveillance and Managem; Intest Res 2011;9(3):196-205. Published online December 30, 2011; DOI: https://doi.org/10.5217/ir.2011.9.3.196

Abstract PDF

Background/Aims
There are no evidence-based, procedural guidelines to appropriately perform a colon polypectomy. Thus, we investigated the treatment modality for colon polypectomy in Korea, using a web-based e-mail survey. Methods: A questionnaire of preferred treatment modality for colon polypectomy was sent via e-mail to members of the Korean Association for the Study of Intestinal Diseases and primary care physicians who performed colonoscopies as a screening or surveillance program nationwide. Among 425 colonoscopists who were sent the e-mail, 263 replied. We analysed data from 252 colonoscopists who had performed colon polypectomies. Results: The stopping time for antiplatelet and anticoagulation therapy before a colon polypectomy had a tendency to increase and the restarting time for these drugs was delayed as polyp size increased. Colonoscopists preferred cold biopsy removal for polyps <5 mm in size and a hot snare polypectomy after injecting normal saline and epinephrine mixture for polyps ≥5 mm in size. More than half of colonoscopists preferred observation rather than additional procedures for adenomas with incomplete resection. In contrast, most colonoscopists recommended additional procedures, such as endoscopic mucosal resection, endoscopic submucosal dissection or surgery for an advanced adenoma with incomplete resection. The most preferred prophylactic treatment for immediate postpolypectomy bleeding washemoclipping. Conclusions: Various treatment modalities were used for a colon polypectomy because there are few guidelines for performing a colon polypectomy based on a critical review of the available data. Further well-designed, prospective studies are needed to develop evidence-based guidelines for colon polypectomy. (Intest Res 2011;9:196- 205)

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A survey of current practices in post-polypectomy surveillance in Korea
Jeongseok Kim, Tae-Geun Gweon, Min Seob Kwak, Su Young Kim, Seong Jung Kim, Hyun Gun Kim, Eun Ran Kim, Sung Noh Hong, Eun Sun Kim, Chang Mo Moon, Dae Seong Myung, Dong Hoon Baek, Shin Ju Oh, Hyun Jung Lee, Ji Young Lee, Yunho Jung, Jaeyoung Chun, Dong-Hoo
Intestinal Research.2024; 22(2): 186. CrossRef
Cold polypectomy techniques for small and diminutive colorectal polyps: a systematic review and network meta-analysis of randomized controlled trials
Mohamed Abuelazm, Ahmed K. Awad, Islam Mohamed, Abdelrahman Mahmoud, Hosam Shaikhkhalil, Nour Shaheen, Omar Abdelwahab, Ahmed M. Afifi, Basel Abdelazeem, Mohamed O. Othman
Current Medical Research and Opinion.2023; 39(10): 1329. CrossRef
Risk of post-polypectomy bleeding after endoscopic mucosal resection in patients receiving antiplatelet medication: comparison between the continue and hold groups
Sang Hyun Park, Soo-Kyung Park, Hyo-Joon Yang, Yoon Suk Jung, Jung Ho Park, Chong Il Sohn, Dong Il Park
Surgical Endoscopy.2022; 36(9): 6410. CrossRef
Colonoscopic Polypectomy Preferences of Asian Endoscopists: Results of a Survey-Based Study
Dong-Hoon Yang, Bayasgalan Luvsandagva, Quang Trung Tran, Achmad Fauzi, Panida Piyachaturawat, Thida Soe, Zhiqin Wong, Jeong-Sik Byeon
Gut and Liver.2021; 15(3): 391. CrossRef
Comparative efficacy of cold polypectomy techniques for diminutive colorectal polyps: a systematic review and network meta-analysis
Yoon Suk Jung, Chan Hyuk Park, Eunwoo Nam, Chang Soo Eun, Dong Il Park, Dong Soo Han
Surgical Endoscopy.2018; 32(3): 1149. CrossRef
Resection of Diminutive and Small Colorectal Polyps: What Is the Optimal Technique?
Jun Lee
Clinical Endoscopy.2016; 49(4): 355. CrossRef

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Association between Thyroid Cancer and Advanced Colorectal Neoplasia: Da Min Kim, Jung Ha Kim, Jun Young Park, Byung Woo Jun, Lim Hwa Song, Hyun Ae Jung, Young-Ho Kim; Intest Res 2011;9(3):206-210. Published online December 30, 2011; DOI: https://doi.org/10.5217/ir.2011.9.3.206

Abstract PDF: Background/Aims
Colorectal cancer and thyroid cancer are common diseases with relatively higher survival rates compared with other cancers. The number of patients identified with colorectal cancer or thyroid cancer who develop multiple primary malignancy during long-term follow-up is increasing with advances in diagnostic techniques and treatment modalities. However, the association between colorectal cancer and thyroid cancer is uncertain, and few data have been reported in Korea. This study examined the association between thyroid cancer and colorectal neoplasm. Methods: We retrospectively investigated 363 patients who underwent a colonoscopy, among patients diagnosed with thyroid cancer between January 2004 and December 2008 at Samsung Medical Center. The control group was comprised of 2,494 patients who underwent screening colonoscopy for the first time within the study period at the center for health promotion at Samsung Medical Center between March 2004 and December 2005. Results: The detection rates in patients with thyroid cancer were 4.7% (17/363) for advanced adenomas and 2.8% (10/363) for colorectal cancer. In the control group, it was 3.2% (79/2,494) for advanced adenomas and 0.3% (7/2,494) for colorectal cancer. A multivariate analysis revealed that the presence of thyroid cancer had an odds ratio of 1.893 (95% confidence interval, 0.868-4.128, P=0.109) in favor of finding at least one advanced colorectal neoplasm. Conclusions: The results indicate that thyroid cancer is not associated with advanced colorectal neoplasm. Survivors of thyroid and colorectal cancer live longer and hence are at risk for second primary cancers. Therefore, further studies that prospectively evaluate the association between thyroid cancer and colorectal advanced neoplasm are needed. (Intest Res 2011;9:206-210)

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Endoscopic Treatment Strategy for Large Laterally Spreading Tumor: Endoscopic Piecemeal Mucosal Resection or Endoscopic Submucosal Dissection: Sang Goo Kang, Suck-Ho Lee, Seung Kyu Chung, Jae Min Shin, Seong Ran Jeon, Tae Hee Lee, Hyun Gun Kim, Jin Oh Kim; Intest Res 2011;9(3):211-216. Published online December 30, 2011; DOI: https://doi.org/10.5217/ir.2011.9.3.211

Abstract PDF

Background/Aims
The therapeutic strategy between endoscopic piecemeal mucosal resection (EPMR) and endoscopic submucosal dissection (ESD) for large laterally spreading tumors (LSTs) has not been clearly defined. The aim of this study was to compare the clinical outcomes between EPMR and ESD in patients with large LST. Methods: From July 2006 to September 2010, 106 patients who underwent endoscopic resection for large (＞20 mm) LSTs were included in our retrospective analysis. Results: Baseline characteristics of the patients and tumors were not different between two groups except for location (EPMR-right colon, ESD-rectum). The en bloc resection rate and complete resection rate were significantly higher in the ESD group than those in the EPMR group (EPMR vs. ESD, 53.5% vs. 88.6, P＜0.01, 45.1% vs. 71.4%, P=0.01, respectively). However, total procedure time was significantly shorter in the EPMR group (21.3 min vs. 44.4 min, P＜0.01). Furthermore, the rates of complication including perforation and bleeding were significantly lower in the EPMR group than those in the ESD group (perforation, 1.4% vs. 11.4%, P=0.02; bleeding, 4.2% vs. 17.1%, P=0.03, respectively). During 19.9 months of follow-up, no significant difference was observed in terms of recurrence (1.5% vs. 3.2%). Non-granular, pseudo-depressed type (LST-PD) showed a significantly higher presence of adenocarcinoma and deeper submucosal invasion than other types of LSTs. Conclusions: The therapeutic strategy for choosing between EPMR and ESD for large LST lesions should be determined based on the macroscopic findings of their subtype. En bloc resection with ESD should be applied to LST-PDs due to their higher rate of submucosal invasion. (Intest Res 2011;9:211-216)

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Long‐term clinical outcomes of endoscopic submucosal dissection for colorectal neoplasia with or without the hybrid technique
DU Kang, JC Park, SW Hwang, SH Park, DH Yang, KJ Kim, BD Ye, SJ Myung, SK Yang, JS Byeon
Colorectal Disease.2020; 22(12): 2008. CrossRef
Current practices in endoscopic submucosal dissection for colorectal neoplasms: a survey of indications among Korean endoscopists
Tae Jun Kim, Eun Ran Kim, Sung Noh Hong, Young-Ho Kim, Dong Kyung Chang
Intestinal Research.2017; 15(2): 228. CrossRef

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Endoscopic Resection for Rectal Carcinoid Tumor: Efficacy and Clinical Results of Follow-up: Gwang Un Kim, Byong Duk Ye, Jeong-Sik Byeon, Hwan Sung Park, Tae Jin Ok, Dong-Hoon Yang, Kee Wook Jung, Kyung Jo Kim, Seung-Jae Myung, Suk-Kyun Yang, Jin-Ho Kim; Intest Res 2011;9(3):217-224. Published online December 30, 2011; DOI: https://doi.org/10.5217/ir.2011.9.3.217

Abstract PDF

Background/Aims
With the growing volume of screening colonoscopies, the incidence of rectal carcinoids and the number of endoscopic resections for rectal carcinoids are also increasing. However, the prognosis including recurrence and metachronous lesions after endoscopic resection is unclear. Methods: The medical records of 255 patients who had undergone endoscopic resection for rectal carcinoids between October 1999 and April 2010 were retrospectively reviewed. Results: The number of males was 150 (58.8%), and the mean age was 54.1 years (range, 27-85 years). Mean tumor size was 6.9 mm. In total, 162 cases (63.5%) were treated with endoscopic mucosal resection and 93 (36.5%) were treated with endoscopic submucosal dissection. Although endoscopic complete resections were achieved in all cases, the histological examination showed 47 cases with a positive resection margin (18.4%) and three with lymphovascular invasion (1.2%). In the 54 patients with a free resection margin, who were followed for more than 12 months, abdominopelvic computed tomography and endoscopy did not show recurrence after a median of 30.5 and 36 months, respectively. Three patients with lymphovascular invasion did not show recurrence during follow-up period of 13, 30, and 37 months, respectively. Metachronous rectal carcinoids were detected in four patients at 23, 58, 61, and 89 months, respectively, after initial endoscopic resection, leading to a second endoscopic treatment. Conclusions: Small rectal carcinoids completely resected grossly and pathologically without lymphovascular invasion appear to have low probability of short-term recurrence. However, considering the slow growth rate of carcinoids, long-term follow-up for recurrence and metachronous carcinoids is required. (Intest Res 2011;9:217-224)

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Clinical outcomes and risk factors associated with poor prognosis after endoscopic resection of 10–20 mm rectal neuroendocrine tumors: a multicenter, retrospective study of 10-year experience
Ja Jun Goo, Dong Hoon Baek, Hyung Wook Kim, Hong Sub Lee, Jong Yoon Lee, Su Bum Park, Geun Am Song, Sang Heon Lee, Jong Hoon Lee
Surgical Endoscopy.2023; 37(7): 5196. CrossRef
Risk Factors for Lymph Node Metastasis and Oncologic Outcomes in Small Rectal Neuroendocrine Tumors with Lymphovascular Invasion
Seung-Joo Nam, Byung Chang Kim, Hee Jin Chang, Han Ho Jeon, Junho Kim, Su Young Kim
Gut and Liver.2022; 16(2): 228. CrossRef
Multiple small, rectal neuroendocrine tumors with numerous micronests
Sung Sil Park, Nayoung Han, Jihyeon Lee, Hee Jin Chang, Jae Hwan Oh, Dae Kyung Sohn
Journal of Digestive Diseases.2018; 19(9): 572. CrossRef
Clinical outcomes of endoscopic mucosal resection for rectal neuroendocrine tumor
Jihye Kim, Jee Hyun Kim, Joo Young Lee, Jaeyoung Chun, Jong Pil Im, Joo Sung Kim
BMC Gastroenterology.2018;[Epub] CrossRef
Are Small Rectal Neuroendocrine Tumors Safe?
Jae Ho Choi, Jae Myung Cha
Intestinal Research.2015; 13(2): 103. CrossRef
Appendiceal Neuroendocrine Tumor with Lymph Node Metastasis in a Teenager
Keun Young Kim, Won Cheol Park
The Korean Journal of Gastroenterology.2015; 65(2): 127. CrossRef

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A Case of Pyoderma Gangrenosum of the Face Associated with Ulcerative Colitis: Eun Sil Kim, Min Ho Seo, Hyuk Soon Choi, Bora Keum, Yeon Seok Seo, Yong Sik Kim, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Soon Ho Um, Chang Duck Kim, Ho Sang Ryu; Intest Res 2011;9(3):225-229. Published online December 30, 2011; DOI: https://doi.org/10.5217/ir.2011.9.3.225

Abstract PDF: Ulcerative colitis is associated with various extra-intestinal manifestations, including rheumatic, dermatologic, ophthalmologic, biliary, and hematologic manifestations. Cutaneous findings are common extra-intestinal manifestations of ulcerative colitis, occurring in 10-20% of patients. Cutaneous manifestations include erythema nodosum, pyoderma gangrenosum, aphthous stomatitis, and acute febrile neutrophilic dermatosis. Treatments for these cutaneous manifestations include corticosteroids, cyclosporine, tacrolimus, mycophenolate mofetil, azathioprine, and infliximab. A 48-year-old male presented with an acute exacerbation of ulcerative colitis associated with multiple skin lesions on his face, thumbs, thighs, and feet. The final impression was neutrophilic folliculitis, which is an early form of pyoderma gangrenosum. The patient's skin lesions and colitis both improved with corticosteroids. There are rare published case reports of ulcerative colitis exacerbations associated with pyoderma gangrenosum that initiated as neutrophilic folliculitis of the face. This case report includes a review of the literature. (Intest Res 2011;9:225-229)

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A Case of Right Side Ischemic Colitis Associated with Herbal Medication for Weight Reduction in a Young Woman: Nam Jun Kim, Chung Hun Kim, Jin Hyun Cho, Sung Min Ko, Byung-Hoon Min; Intest Res 2011;9(3):230-233. Published online December 30, 2011; DOI: https://doi.org/10.5217/ir.2011.9.3.230

Abstract PDF: Ischemic colitis has a relatively high prevalence in the elderly population with underlying vascular disorders such as hypertension and usually occurs on the left side of the colon. However, ischemic colitis also rarely occurs in healthy young adults with no risk factors. Herbal medication use is increasing, particularly for weight loss. Ischemic colitis associated with herbal medication use has been rarely reported. Here, we describe a case of right-sided ischemic colitis in a young woman that was potentially linked to the use of herbal medication. An 18-year-old woman was admitted to our emergency department with abdominal pain and bloody diarrhea for 1 day. Her medical history was unremarkable for bowel ischemia risk factors. However, she had taken herbal medication for weight loss for the past 2 weeks. Abdominopelvic CT showed diffuse wall thickening with decreased mucosal enhancement from the ascending to the transverse colon. A colonoscopic biopsy specimen showed coagulative necrosis of the mucosa, hemorrhage, and inflammatory cell infiltration. The abdominopelvic CT, colonoscopy, and biopsy findings were compatible with ischemic colitis. Her abdominal pain and bloody diarrhea improved completely with conservative management, and she was advised to discontinue the use of herbal medications. (Intest Res 2011;9:230-233)

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Pneumatosis Cystoides Intestinalis and Partial Abdominal Obstruction in a Patient with Polymyositis: Ji Yeon Kim, Yong Hwan Kwon, Sang Jik Lee, Se Young Jang, Soo Young Park; Intest Res 2011;9(3):234-237. Published online December 30, 2011; DOI: https://doi.org/10.5217/ir.2011.9.3.234

Abstract PDF

Pneumatosis cystoides intestinalis (PCI) is a rare disease characterized by the presence of intramural gas-filled cysts in the gastrointestinal wall. This disease has been documented in patients with various medical conditions such as gastrointestinal disease, chronic obstructive lung disease, sepsis, and autoimmune disorders. A 49-year-old woman, who was undergoing immumosuppressant therapy due to polymyositis, developed PCI. She experienced a gradual onset of abdominal distension. A simple abdominal radiograph revealed small, round air shadows involving the small bowel, and abdominal computed tomography showed intraluminal air bubbles at the jejunal loop with free air in the peritoneum. Treatment with doxycycline effectively relieved the clinical symptoms and reduced the intramural gas. (Intest Res 2011;9:234-237)

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Pneumomediastinum, pneumatosis intestinalis and pneumoperitoneum in a patient with polymyositis: case-based review
Melis Dilbil, Funda Erbasan, Bengisu Aslan, Tahir Saygın Öğüt, Mine Nokay, Veli Yazısız, Mustafa Ender Terzioğlu
Rheumatology International.2022; 43(4): 771. CrossRef
A Case of Pneumatosis Cystoides Intestinalis in a Patient with Dermatomyositis
Dong Jin Go, Jeong Seok Lee, Sang Hyun Joo, Jinyoung Moon, Jae Hyun Lee, Eun Young Lee
Journal of Rheumatic Diseases.2015; 22(4): 238. CrossRef
Pneumatosis Cystoides Intestinalis with Pneumoperitoneum Complicating Systemic Sclerosis: A Case Report
Jae Uk Im, Eun Hye Kim, Hong Gil Jun, Ji Seon Oh, Seung Won Choi, Byeong Seong Kang
Korean Journal of Medicine.2013; 84(6): 868. CrossRef
Recurrent pneumatosis intestinalis in a patient with dermatomyositis
Yousef Zarbalian, Erik C von Rosenvinge, William Twadell, Jamal Mikdashi
BMJ Case Reports.2013; : bcr2013200308. CrossRef

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A Case of Cronkhite-Canada Syndrome Presenting with Hematochezia: Hyun Ji Lee, Sang Jung Park, Hyuk Soon Choi, Bora Keum, Yeon Seok Seo, Yong Sik Kim, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Soon Ho Um, Chang Duck Kim, Ho Sang Ryu; Intest Res 2011;9(3):238-242. Published online December 30, 2011; DOI: https://doi.org/10.5217/ir.2011.9.3.238

Abstract PDF

Cronkhite-Canada syndrome (CCS) is a rare, non-familial hamartomatous polyposis syndrome characterized by multiple polyps in the entire gastrointestinal tract, nail dystrophy, skin pigmentation, and systemic alopecia. The clinical symptoms of this syndrome include diarrhea, abdominal pain, and alopecia often accompanied by taste disturbances, hypoalbuminemia, recurrent infections, nutritional absorption disturbances, heart failure, and gastrointestinal bleeding. We report a patient with CCS who was admitted complaining of hematochezia, melena, and a 1 month history of diarrhea, nail changes, taste disturbances, and alopecia. Upper endoscopy, colonoscopy, and capsule endoscopy were performed and showed numerous polyps in the stomach, small intestine, and large intestine. Histological sections of these polyps showed edematous stroma and cystically dilated foveolar epithelium, which was consistent with CCS. We diagnosed CCS based on the clinical symptoms and the histological findings of the polyps found via endoscopy. We report on this case and review this syndrome. (Intest Res 2011;9:238-242)

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Cronkhite-Canada Syndrome Associated with Serrated Adenoma and Malignant Polyp: A Case Report and a Literature Review of 13 Cronkhite-Canada Syndrome Cases in Korea
So Hee Yun, Jin Woong Cho, Ji Woong Kim, Joong Keun Kim, Moon Sik Park, Na Eun Lee, Jae Un Lee, Young Jae Lee
Clinical Endoscopy.2013; 46(3): 301. CrossRef
A Case of Cronkhite-Canada Syndrome Showing Spontaneous Remission
Dong-Uk Kang, Dong-Hoon Yang, Yunsik Choi, Ji-Beom Kim, Ho-Su Lee, Hyo Jeong Lee, Sang Hyoung Park, Kee Wook Jung, Kyung-Jo Kim, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Jin-Ho Kim
Intestinal Research.2013; 11(4): 317. CrossRef

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Duodenal Diverticulitis Due to Impacted Foreign Body: Enteroscopic Diagnosis and Treatment: Seung Mo Kang, Yunju Jo, Young Kwan Cho, Sang Bong Ahn, Seong Hwan Kim, Young Sook Park; Intest Res 2011;9(3):243-246. Published online December 30, 2011; DOI: https://doi.org/10.5217/ir.2011.9.3.243

Abstract PDF: Duodenal diverticulitis is a rare complication of the duodenal diverticulum. Its rarity is due to the relatively large diameter of the duodenum, which makes the intraluminal flow of sterile liquid duodenal contents fluent. Additionally, nonspecific signs and symptoms of duodenal diverticulitis make it very difficult to diagnose properly. We describe a patient presenting with abdominal pain, nausea, and leukocytosis, with diverticulitis of the third portion of the duodenum caused by the impaction of a foreign body, who was diagnosed and treated with enteroscopy. (Intest Res 2011;9:243-246)

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Use of Aspirin or Nonsteroidal Anti-inflammaotory Drugs Increases Risk for Diverticulitis and Diverticular Bleeding (Gastroenterology 2011;140:1427-1433): Rok Seon Choung; Intest Res 2011;9(3):247-249. Published online December 30, 2011; DOI: https://doi.org/10.5217/ir.2011.9.3.247

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Anti-oxidant and Anti-inflammatory Effects of Chulbu-tang
Kyun Hyeong, Je-Hoon Won, Chang-Hoon Woo
Journal of Korean Medicine Rehabilitation.2020; 30(3): 71. CrossRef

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