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IBD
Asian–Pacific perspectives on the management of very early-onset inflammatory bowel disease
Ichiro Takeuchi, Katsuhiro Arai, Pornthep Tanpowpong, Ming-Wei Lai, Andrew S Day, Way Seah Lee, James Guoxian Huang, Karen Sophia Calixto-Mercado, Rosanna Ming Sum Wong, Muhammad Arshad Alvi, Zubin Grover, Jung Ok Shim, Ujjal Poddar
Intest Res 2025;23(4):405-429.   Published online October 28, 2025
DOI: https://doi.org/10.5217/ir.2025.00082
AbstractAbstract PDFPubReaderePub
Children diagnosed with inflammatory bowel disease (IBD) before the age of 6 years are considered to have “very early-onset IBD (VEO-IBD),” which is challenging to diagnose and treat. Notably, many children with VEO-IBD have monogenic forms of the disease, meaning that early genetic testing is useful. However, because the prevalence of genetic variants causing VEO-IBD differs globally, the diagnosis and treatment of this disease should be tailored to each region. In the present review paper, the IBD Subcommittee of the Scientific Committee of the Asia-Pacific Society of Pediatric Gastroenterology, Hepatology and Nutrition (APSPGHAN) has summarized the epidemiology, presenting features, diagnosis, and treatment of VEO-IBD in the Asia– Pacific region, with an aim to guide clinicians and researchers who work with VEO-IBD in this area. Our 3 main messages are as follows: endoscopy is essential for VEO-IBD diagnosis; all children diagnosed with VEO-IBD should be suspected of having a monogenic form; and children with suspected monogenic IBD should undergo early genetic testing. Our messages aim to improve the early diagnosis and treatment of VEO-IBD in the Asia–Pacific region, including the early detection of monogenic IBD in this area.

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Citations to this article as recorded by  
  • Clinical Phenotypes and Genetic Findings in Very-Early-Onset Inflammatory Bowel Disease: A Vietnamese Pediatric Cohort Study
    Manh Cuong Nguyen, Thi Viet Ha Nguyen, Loi Nguyen, Thuy Ha Dang, Tam Tran, Thi Van Anh Nguyen, Ngoc Thach Hoang, Ngoc Quynh Le Nguyen, Thi Minh Phuong Do, Van Tinh Nguyen, Hai Yen Vu, Thi Ngoc Hong Nguyen, Thi Thu Trang Nguyen, Thi Cam Van Le, Thi Khanh N
    Children.2026; 13(5): 666.     CrossRef
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  • 1 Web of Science
  • 1 Crossref
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IBD
An overview of the role of exclusive enteral nutrition for complicated Crohn’s disease
Mustafa Adamji, Andrew S Day
Intest Res 2019;17(2):171-176.   Published online December 3, 2018
DOI: https://doi.org/10.5217/ir.2018.00079
AbstractAbstract PDFPubReaderePub
The role and efficacy of exclusive enteral nutrition (EEN) in the treatment of luminal Crohn’s disease (CD) has been well established over the last 2 decades. Consequently, in many centers nutritional therapy is now considered first line therapy in the induction of remission of active CD. However, the use of nutritional therapy in complicated CD has yet to be fully determined. This article aimed to review case reports and clinical trials published in the last decade that have considered and evaluated nutritional therapy in the setting of complicated CD in children and adults. Published literature focusing upon the use of nutritional therapy as part of medical therapy in the management of complicated CD were identified and reviewed. Although there continue to be various interventions utilized for complicated CD, the currently available literature demonstrates that nutritional therapies, especially EEN, have important roles in the management of these complex scenarios. Further assessments, involving large numbers of patients managed with consistent approaches, are required to further substantiate these roles.

Citations

Citations to this article as recorded by  
  • Diet in Inflammatory Bowel Diseases: Efficacy, Tolerability, and Microbiome Effects Toward Personalized Management
    Francesco Calabrese, Andrea Pasta, Elena Formisano, Elisa Marabotto, Manuele Furnari, Livia Pisciotta, Patrizia Zentilin, Edoardo G. Giannini, Giorgia Bodini
    Digestive Diseases and Sciences.2026; 71(5): 1650.     CrossRef
  • Crohnʼs Disease Exclusion Diet (CDED) und partielle enterale Ernährungstherapie (PEN) zur Remissionsinduktion bei Kindern und Jugendlichen mit Morbus Crohn – Aktualisierte Stellungnahme der Arbeitsgemeinschaften CEDATA und Ernährung/Diätetik/Ernährungsmed
    Evdokia Alexanidou, André Hörning, Jan de Laffolie, Anjona Schmidt-Choudhury, Jan Däbritz, AG Ernährung und CEDATA-Studiengruppe
    Zeitschrift für Gastroenterologie.2026; 64(02): 184.     CrossRef
  • Adjunct polymeric exclusive enteral nutrition helps achieve biochemical remission in active Crohn’s disease in adults irrespective of disease location and concomitant corticosteroid use
    Hellen Kuo, Katrina Tognolini, Rumbidzai Mutsekwa, Dheeraj Shukla, Laura Willmann, Hadi Moattar, Alexander Dorrington, Naveed Ishaq, Maneesha Bhullar, John Edwards, Waled Mohsen, Pradeep Kakkadasam Ramaswamy
    Frontline Gastroenterology.2025; 16(1): 3.     CrossRef
  • Partial Enteral Nutrition in the Management of Crohn’s Disease: A Systematic Review and Meta-Analysis
    Aleksandra Jatkowska, Bernadette White, Konstantinos Gkikas, John Paul Seenan, Jonathan MacDonald, Konstantinos Gerasimidis
    Journal of Crohn's and Colitis.2025;[Epub]     CrossRef
  • Positionspapier der Gesellschaft für Pädiatrische Gastroenterologie und Ernährung (GPGE) zum zulassungsüberschreitenden Gebrauch von für Erwachsene mit CED zugelassenen Biologika und Signalinhibitoren bei Kindern und Jugendlichen
    Jan Däbritz, Martin Classen, Kathrin Krohn, Andreas Krahl, Stephan Buderus, Elke Lainka, Jan de Laffolie, Carsten Posovszky
    Zeitschrift für Gastroenterologie.2025; 63(03): 255.     CrossRef
  • Understanding Role of Nutrition in Inflammatory Bowel Disease: A Comprehensive Review With Incorporation of AGA Update
    Galvin Dhaliwal, Dushyant Singh Dahiya, Ashvin Singh Dhaliwal, Hassam Ali, Manesh Kumar Gangwani, Fouad Jaber, Saqr Alsakarneh, Islam Mohamed, Umar Hayat, Bhanu Siva Mohan Pinnam, Sahib Singh, Sasha Mangray, Stephen Bickston
    Journal of Gastroenterology and Hepatology.2025; 40(6): 1352.     CrossRef
  • TPMT and HLA-DQ Allelic Variants in Relation to Drug Response, Safety and Need for Therapy Optimization in Pediatric Inflammatory Bowel Disease
    Mirjana Stojšić, Ognjen Ležakov, Sanja Ćeranić, Nikola Stojšić, Marko Rajković, Savina Marković, Milica Kovačević, Nina Brkić
    Children.2025; 12(10): 1334.     CrossRef
  • Human Gut Microbiome in Relation to Food, Nutrition, Health and Disease
    Mirjana Menkovska, Sabeen Raza
    Advances in Bioscience and Biotechnology.2025; 16(12): 550.     CrossRef
  • From the gut to the brain: Potential novel avenues for IBD treatment via serotonergic pathways
    Sara Ibgui, Daisy Lints, Simon Milling
    Pharmacological Research.2025; 222: 108059.     CrossRef
  • Mycobacterium avium ssp. paratuberculosis and Crohn’s Disease—Diagnostic Microbiological Investigations Can Inform New Therapeutic Approaches
    John M. Aitken, Jack E. Aitken, Gaurav Agrawal
    Antibiotics.2024; 13(2): 158.     CrossRef
  • Aktualisierte S3-Leitlinie „Diagnostik und Therapie des Morbus Crohn“ der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) (Version 4.1) – living guideline
    Andreas Sturm, Raja Atreya, Dominik Bettenworth, Bernd Bokemeyer, Axel Dignass, Robert Ehehalt, Christoph-Thomas Germer, P. C. Grunert, Ulf Helwig, Karoline Horisberger, Klaus Herrlinger, Peter Kienle, Torsten Kucharzik, Jost Langhorst, Christian Maaser,
    Zeitschrift für Gastroenterologie.2024; 62(08): 1229.     CrossRef
  • Mechanisms of Action of Exclusive Enteral Nutrition and Other Nutritional Therapies in Crohn’s Disease
    Ramasatyaveni Geesala, Pratik Gongloor, Neeraja Recharla, Xuan-Zheng Shi
    Nutrients.2024; 16(21): 3581.     CrossRef
  • Is Salt at Fault? Dietary Salt Consumption and Inflammatory Bowel Disease
    Rebecca Kuang, Stephen J D O’Keefe, Claudia Ramos del Aguila de Rivers, Filippos Koutroumpakis, David G Binion
    Inflammatory Bowel Diseases.2023; 29(1): 140.     CrossRef
  • The Role of the Gut Microbiota in the Relationship Between Diet and Human Health
    Bryce K. Perler, Elliot S. Friedman, Gary D. Wu
    Annual Review of Physiology.2023; 85(1): 449.     CrossRef
  • Global research trends on diet and nutrition in Crohn’s disease
    Muna Shakhshir, Sa'ed H Zyoud
    World Journal of Gastroenterology.2023; 29(20): 3203.     CrossRef
  • Enterale Ernährungstherapien beim pädiatrischen M. Crohn Anwendungen und Wirkweise
    André Hörning, Anjona Schmidt-Choudhury
    Aktuelle Ernährungsmedizin.2023; 48(03): 183.     CrossRef
  • Identifying Microbiome Dynamics in Pediatric IBD: More than a Family Matter
    Nikolas Dovrolis, Anastasia Moschoviti, Smaragdi Fessatou, George Karamanolis, George Kolios, Maria Gazouli
    Biomedicines.2023; 11(7): 1979.     CrossRef
  • Unraveling the Impact of Gut and Oral Microbiome on Gut Health in Inflammatory Bowel Diseases
    Hala Elzayat, Ghaidaa Mesto, Farah Al-Marzooq
    Nutrients.2023; 15(15): 3377.     CrossRef
  • Interplay between inflammatory bowel disease therapeutics and the gut microbiome reveals opportunities for novel treatment approaches
    Catherine O’Reilly, Susan Mills, Mary C. Rea, Aonghus Lavelle, Subrata Ghosh, Colin Hill, R. Paul Ross
    Microbiome Research Reports.2023;[Epub]     CrossRef
  • Current understanding of the aetiology and pathogenesis of inflammatory bowel diseases (Part 2): the role of the microbiome and nutritional factors
    A. I. Khavkin, K. M. Nikolaychuk, E. V. Shrayner, D. R. Shaimardanova, A. S. Veremenko, I. D. Levchenko, P. Ya. Platonova, M. F. Novikova, V. V. Dudurich
    Experimental and Clinical Gastroenterology.2023; (12): 164.     CrossRef
  • FODMAPs, inflammatory bowel disease and gut microbiota: updated overview on the current evidence
    Catarina D. Simões, Marta Maganinho, Ana S. Sousa
    European Journal of Nutrition.2022; 61(3): 1187.     CrossRef
  • Effects of Olive Oil and Its Components on Intestinal Inflammation and Inflammatory Bowel Disease
    Josip Vrdoljak, Marko Kumric, Marino Vilovic, Dinko Martinovic, Iris Jeroncic Tomic, Mladen Krnic, Tina Ticinovic Kurir, Josko Bozic
    Nutrients.2022; 14(4): 757.     CrossRef
  • Exclusive enteral nutrition: An optimal care pathway for use in children with active luminal Crohn's disease
    Deirdre Burgess, Kathleen H McGrath, Caitlin Watson, Tanya Collins, Stephanie Brown, Katie Marks, Kate Dehlsen, Kim Herbison, Emma Landorf, Laura Benn, Julia Fox, Ming Liew
    Journal of Paediatrics and Child Health.2022; 58(4): 572.     CrossRef
  • Aktualisierte S3-Leitlinie „Diagnostik und Therapie des Morbus Crohn“ der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – August 2021 – AWMF-Registernummer: 021-004
    Andreas Sturm, Raja Atreya, Dominik Bettenworth, Bernd Bokemeyer, Axel Dignaß, Robert Ehehalt, Christoph Germer, Philip C. Grunert, Ulf Helwig, Klaus Herrlinger, Peter Kienle, Martin E. Kreis, Torsten Kucharzik, Jost Langhorst, Christian Maaser, Johann Oc
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  • The Optimal Management of Fistulizing Crohn’s Disease: Evidence beyond Randomized Clinical Trials
    Panu Wetwittayakhlang, Alex Al Khoury, Gustavo Drügg Hahn, Peter Laszlo Lakatos
    Journal of Clinical Medicine.2022; 11(11): 3045.     CrossRef
  • Laser Therapy in Perianal Fistulas
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    Applied Sciences.2022; 12(23): 12433.     CrossRef
  • Enterale Ernährungstherapien beim pädiatrischen M. Crohn
    André Hörning, Anjona Schmidt-Choudhury
    Kinder- und Jugendmedizin.2022; 22(06): 439.     CrossRef
  • Dietary patterns, beliefs and behaviours among individuals with inflammatory bowel disease: a cross‐sectional study
    K. J. Kamp, B. Pennings, D. Javelli, G. Wyatt, B. Given
    Journal of Human Nutrition and Dietetics.2021; 34(2): 257.     CrossRef
  • Alterations in drug disposition in older adults: a focus on geriatric syndromes
    Dorsa Maher, Nagham Ailabouni, Arduino A. Mangoni, Michael D. Wiese, Emily Reeve
    Expert Opinion on Drug Metabolism & Toxicology.2021; 17(1): 41.     CrossRef
  • Nutritional Therapy Strategies in Pediatric Crohn’s Disease
    Charlotte M. Verburgt, Mohammed Ghiboub, Marc A. Benninga, Wouter J. de Jonge, Johan E. Van Limbergen
    Nutrients.2021; 13(1): 212.     CrossRef
  • Enteral nutrition modulation with n-3 PUFAs directs microbiome and lipid metabolism in mice
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    PLOS ONE.2021; 16(3): e0248482.     CrossRef
  • Fish Sidestream-Derived Protein Hydrolysates Suppress DSS-Induced Colitis by Modulating Intestinal Inflammation in Mice
    Maria G. Daskalaki, Konstantinos Axarlis, Tone Aspevik, Michail Orfanakis, Ourania Kolliniati, Ioanna Lapi, Maria Tzardi, Eirini Dermitzaki, Maria Venihaki, Katerina Kousoulaki, Christos Tsatsanis
    Marine Drugs.2021; 19(6): 312.     CrossRef
  • Efficacy and tolerability of exclusive enteral nutrition in adult patients with complicated Crohn’s disease
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  • The Effect of Formula-based Nutritional Treatment on Colitis in a Murine Model
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    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Efficacy of Exclusive Enteral Nutrition in Pediatric Crohn’s Disease
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    Nutrición Clínica y Dietética Hospitalaria.2021;[Epub]     CrossRef
  • 14,224 View
  • 316 Download
  • 34 Web of Science
  • 36 Crossref
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