Intestinal Research

Review

Recent Updates on the Treatment of Constipation: Han Seung Ryu, Suck Chei Choi; Intest Res 2015;13(4):297-305. Published online October 15, 2015; DOI: https://doi.org/10.5217/ir.2015.13.4.297

The treatment of constipation aims to regulate the frequency and quantity of stool in order to promote successful defecation. Numerous studies on pharmacologic treatments and non-pharmacologic therapies for constipation have attempted to overcome limitations such as temporary and insufficient efficacy. Conventional laxatives have less adverse effects and are inexpensive, but often have limited efficacy. Recently developed enterokinetic agents and intestinal secretagogues have received attention owing to their high efficacies and low incidences of adverse events. Studies on biofeedback and surgical treatment have focused on improving symptoms as well as quality of life for patients with refractory constipation.

Citations

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Journal of Translational Medicine.2025;[Epub] CrossRef
EFFICACY AND SAFETY OF INTESTINAL SECRETAGOGUES FOR CHRONIC CONSTIPATION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Juan Sebastian LASA, María Josefina ALTAMIRANO, Luis Florez BRACHO, Silvina PAZ, Ignacio ZUBIAURRE
Arquivos de Gastroenterologia.2018; 55(suppl 1): 2. CrossRef
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Hyo Jeong Lee, Kee Wook Jung, Sun Ju Chung, Seung-Mo Hong, Juyeon Kim, Jeong Hoon Lee, Sung Wook Hwang, Ho-Sung Ryu, Mi Jung Kim, Ho-Su Lee, Myeongsook Seo, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Jaewon Choe, Hwoon-Yong Jung, Suk
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European Journal of Integrative Medicine.2018; 24: 23. CrossRef

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Original Article

Risk Factors for Recurrent Clostridium difficile Infection: Han Seung Ryu, Yong Sung Kim, Geom Seog Seo, Yu Min Lee, Suck Chei Choi; Intest Res 2012;10(2):176-182. Published online April 30, 2012; DOI: https://doi.org/10.5217/ir.2012.10.2.176

Abstract PDF

Background/Aims
Clostridium difficile infection (CDI) is a common nosocomial infection associated with substantial morbidity, mortality and increased medical care costs. Although most patients initially respond to therapy, with either metronidazole or vancomycin, about 15-20% of patients experience recurrence. The aim of this study was to analyze the risk factors related to recurrent CDI (RCDI). Methods: We retrospectively reviewed data, from patients diagnosed with CDI during admission at a university hospital between January 2000 and December 2006, for comparison with data from RCDI patients. Results: Among a total of 294 CDI patients, 32 (10.8%) had experienced RCDI. Risk factors for RCDI included anemia, congestive heart failure, respiratory infection, time between admission and CDI diagnosis, duration of antibiotic therapy prior to CDI diagnosis, tube feeding, and gastrointestinal endoscopy. Multivariate analysis revealed that tube feeding was associated with recurrence (odds ratio, 3.65; 95% confidence interval, 1.38-9.65; P=0.009). Conclusions: Patients who received tube feeding were at increased risk of RCDI. Targeting these patients for preventive strategies may contribute to a reduction in the incidence of RCDI. (Intest Res 2012;10: 0-182)

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