Intestinal Research

Original Articles

Inflammatory Bowel Diseases

The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis: Yujin Jeong, Seong Ran Jeon, Hyun Gun Kim, Jung Rock Moon, Tae Hee Lee, Jae Young Jang, Jun-Hyung Cho, Jun Seok Park, Heesu Park, Ki-hun Lee, Jin-Oh Kim, Joon Seong Lee, Bong Min Ko, Suyeon Park; Intest Res 2021;19(1):62-70. Published online May 8, 2020; DOI: https://doi.org/10.5217/ir.2019.09156

Background/Aims
Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) can serve as biomarkers for diagnosing and assessing disease activity in ulcerative colitis (UC). We investigated their clinical significance in UC.
Methods
We analyzed 48 patients with UC who underwent measurement of fecal calprotectin (FC) and endoscopy and 96 age- and sex-matched healthy controls. NLR and PLR were compared between the patients and healthy controls. The endoscopic activity was divided into 2 groups: group 1 (mild to moderate inflammation) and group 2 (severe inflammation) according to the Mayo endoscopic subscore in UC.
Results
To diagnose UC, the optimal cutoff of NLR and PLR was 2.26 (sensitivity 54.2%; specificity 90.6%; positive likelihood ratio 5.778, 95% confidence interval [CI] 2.944–11.339; area under the curve [AUC] 0.774, 95% CI, 0.690–0.859) and 179.8 (sensitivity 35.4%; specificity 90.6%; positive likelihood ratio 3.778, 95% CI 1.821–7.838; AUC 0.654, 95% CI 0.556–0.753), respectively. The optimal cutoff to differentiate group 1 and group 2 was 3.44, 175.9, and 453 µg/g for NLR, PLR, and FC, respectively (sensitivity, 63.6% vs. 90.9% vs. 81.8%; specificity, 81.1% vs. 78.4% vs. 73.0%; positive likelihood ratio, 3.364 vs. 4.205 vs. 3.027; AUC, 0.714 vs. 0.897 vs. 0.813). PLR had the highest AUC and positive likelihood ratio.
Conclusions
NLR and PLR help differentiate patients with UC from healthy controls. NLR, PLR, and FC indicate endoscopic activity and may reflect intestinal mucosal conditions.

Citations

Citations to this article as recorded by

Predictive Value of Albumin to Fibrinogen Ratio and CALLY Index for Diagnosis of Ulcerative Colitis and Mucosal Healing After Vedolizumab Treatment
Kairong Su, Sinan Xiao, Mei Wang, Kairuo Wang, Qing Fan, Sumei Sha, Yongli Cheng, Xin Liu, Haitao Shi
Journal of Inflammation Research.2025; Volume 18: 589. CrossRef
The ability of C-reactive protein-albumin ratio to predict disease activity in ulcerative colitis
Ibrahimhalil Dusunceli, Zeynep Gok Sargin, Umut Celik, Fatih Sargin
Biomarkers in Medicine.2025; 19(4): 113. CrossRef
Exploring the utility of cellular indices in the diagnosis of ulcerative colitis
Julio César Moreno Alfonso, Sharom Barbosa-Velásquez, Carlos Delgado-Miguel, Ada Molina Caballero, Sara Hernández-Martín, Alberto Pérez Martínez, María Concepción Yárnoz Irazábal
Gastroenterología y Hepatología.2025; : 502349. CrossRef
Ischemia-modified albumin: a novel blood marker of endoscopic mucosal healing in inflammatory bowel disease
Seung Bum Lee, Hyun-Ki Kim, Sang Hyuk Park, Ji-Hun Lim, Sang Hyoung Park
Intestinal Research.2024; 22(1): 75. CrossRef
Evaluation of the prognostic nutritional index (PNI) as a tool for assessing disease activity in rheumatoid arthritis patients
Nuran Öz, Halise Hande Gezer, Selin Cilli Hayıroğlu, Mehmet Tuncay Duruöz
Clinical Rheumatology.2024; 43(5): 1461. CrossRef
Progress in Biomarkers of Inflammatory Bowel Disease
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Advances in Clinical Medicine.2024; 14(03): 1418. CrossRef
Fecal calprotectin and platelet count predict histologic disease activity in pediatric ulcerative colitis: results from a projection-predictive feature selection
B. Schiller, E. Wirthgen, F. Weber, S. Schiller, M. Radke, M. Claßen, J. Däbritz, S. Buderus, P. Bufler, J. Däbritz, S. Dammann, J. de Laffolie, M. Friedt, A. Hauer, K. M. Keller, A. Krahl, M. Laaß, T. Lang, C. Posovszky, B. Rodeck, S. Trenkel
European Journal of Pediatrics.2024; 183(8): 3277. CrossRef
Association of Hemogram Parameters with Body Mass Index in Knee Osteoarthritis
Koksal Gundogdu, Gülşah Gündoğdu, Alper Kurtoğlu
Online Türk Sağlık Bilimleri Dergisi.2024; 9(3): 202. CrossRef
Systemic Immune-Inflammation Index: Unveiling the Diagnostic Potential in Ulcerative Colitis through a Comprehensive Systematic Review and Meta-Analysis
Anas Elgenidy, Omar Alomari, Tasbih Emad, Sara K. Kamal, Islam E. Al Ghanam, Aya Sherif, Mohammed Al-mahdi Al-kurdi, Abdallah A. Helal, Yusof Mohamed Omar, Mohamed Rafiek Ramadan
Gastroenterology & Endoscopy.2024;[Epub] CrossRef
CRP/Albumin Ratio as Potential Indicator for Assessment of Disease Activity in Inflammatory Bowel Disease Patients
Fatma Abdel-Kader Attia Mohamed, Eman Refaat Youness, Marwa M. Hassan, Nesma Hassan Hasanein Ashour
Biomedical and Pharmacology Journal.2024; 17(4): 2683. CrossRef
Cytomegalovirus Reactivation in Ulcerative Colitis Patients: Early Indicators
LN Altunal, AS Ozel, C AK
Nigerian Journal of Clinical Practice.2023; 26(6): 765. CrossRef
The role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in the diagnosis and severity of inflammatory bowel disease in children
Arefeh Zahmatkesh, Mohammad Hassan Sohouli, Seyed Mahmoud Eshagh Hosseini, Pejman Rohani
European Journal of Pediatrics.2023; 182(9): 4263. CrossRef
Ülseratif kolit aktivitesi ve şiddetinin invaziv olmayan biyobelirteçler ile değerlendirilmesi
İlyas TENLİK, Orhan COŞKUN, Mustafa ÇAPRAZ, Volkan GÖKBULUT, Ömer ÖZTÜRK
Akademik Gastroenteroloji Dergisi.2023; 22(2): 59. CrossRef
Interrelation of Hypoxia-Inducible Factor-1 Alpha (HIF-1 α) and the Ratio between the Mean Corpuscular Volume/Lymphocytes (MCVL) and the Cumulative Inflammatory Index (IIC) in Ulcerative Colitis
Ioan Sabin Poenariu, Lidia Boldeanu, Bogdan Silviu Ungureanu, Daniel Cosmin Caragea, Oana Mariana Cristea, Vlad Pădureanu, Isabela Siloși, Anca Marinela Ungureanu, Răzvan-Cristian Statie, Alina Elena Ciobanu, Dan Ionuț Gheonea, Eugen Osiac, Mihail Virgil
Biomedicines.2023; 11(12): 3137. CrossRef
Effect of ozone therapy on neutrophil/lymphocyte, platelet/lymphocyte ratios, and disease activity in ankylosing spondylitis
Habibe İnci, Fatih İnci
Medical Gas Research.2023; 13(2): 53. CrossRef
Biomarker dynamics during infliximab salvage for acute severe ulcerative colitis: C-reactive protein (CRP)-lymphocyte ratio and CRP-albumin ratio are useful in predicting colectomy
Danny Con, Bridgette Andrew, Steven Nicolaides, Daniel R van Langenberg, Abhinav Vasudevan
Intestinal Research.2022; 20(1): 101. CrossRef
Personalized medicine in inflammatory bowel disease: Perspectives on Asia
Su Hyun Park, Sang Hyoung Park
Journal of Gastroenterology and Hepatology.2022; 37(8): 1434. CrossRef
The Usefulness of Extended Inflammation Parameters and Systemic Inflammatory Response Markers in the Diagnostics of Autoimmune Hepatitis
Weronika Domerecka, Anna Kowalska-Kępczyńska, Iwona Homa-Mlak, Agata Michalak, Radosław Mlak, Marcin Mazurek, Halina Cichoż-Lach, Teresa Małecka-Massalska
Cells.2022; 11(16): 2554. CrossRef
Complete Blood Count-Derived Inflammatory Markers Changes in Dogs with Chronic Inflammatory Enteropathy Treated with Adipose-Derived Mesenchymal Stem Cells
José Ignacio Cristóbal, Francisco Javier Duque, Jesús Usón-Casaús, Rafael Barrera, Esther López, Eva María Pérez-Merino
Animals.2022; 12(20): 2798. CrossRef
Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential markers for ulcerative colitis: a retrospective study
Wan Feng, Yajun Liu, Lei Zhu, Luzhou Xu, Hong Shen
BMC Gastroenterology.2022;[Epub] CrossRef
Association of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Diabetic Kidney Disease in Chinese Patients with Type 2 Diabetes: A Cross-Sectional Study
Lan Li, Qing Shen, Sijie Rao
Therapeutics and Clinical Risk Management.2022; Volume 18: 1157. CrossRef
Evaluation of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Chronic Plaque Psoriasis
Sudeshna Mondal, Samudra Guha, Abanti Saha, Loknath Ghoshal, Debabrata Bandyopadhyay
Indian Journal of Dermatology.2022; 67(4): 477. CrossRef
Correlations of disease severity and age with hematology parameter variations in patients with COVID‐19 pre‐ and post‐treatment
Juanying Liang, Shaoyun Nong, Liejun Jiang, Xiaowei Chi, Dewu Bi, Jun Cao, Lida Mo, Xiaolu Luo, Huayi Huang
Journal of Clinical Laboratory Analysis.2021;[Epub] CrossRef
Elevated systemic immune inflammation index level is associated with disease activity in ulcerative colitis patients
Yiyi Xie, Tingting Zhuang, Ying Ping, Yingzhi Zhang, Xuchu Wang, Pan Yu, Xiuzhi Duan
Clinica Chimica Acta.2021; 517: 122. CrossRef
Endoscopy within 7 days after detecting high calprotectin levels can be useful for therapeutic decision-making in ulcerative colitis
Ho Min Yong, Sung-Jo Park, Seong Ran Jeon, Heesu Park, Hyun Gun Kim, Tae Hee Lee, Junseok Park, Jin-Oh Kim, Joon Seong Lee, Bong Min Ko, Hyeon Jeong Goong, Suyeon Park
Medicine.2021; 100(34): e27065. CrossRef
Inflammatory Bowel Disease and Neutrophil–Lymphocyte Ratio: A Systematic Scoping Review
Blake O. Langley, Sara E. Guedry, Joshua Z. Goldenberg, Douglas A. Hanes, Jennifer A. Beardsley, Jennifer Joan Ryan
Journal of Clinical Medicine.2021; 10(18): 4219. CrossRef
Lymphocyte-to-Monocyte Ratio as a Marker for Endoscopic Activity in Ulcerative Colitis
Natsuki Ishida, Satoru Takahashi, Yusuke Asai, Takahiro Miyazu, Satoshi Tamura, Shinya Tani, Mihoko Yamade, Moriya Iwaizumi, Yasushi Hamaya, Satoshi Osawa, Takahisa Furuta, Ken Sugimoto
Immuno.2021; 1(4): 360. CrossRef
Peripheral blood neutrophil-to-lymphocyte ratio in inflammatory bowel disease and disease activity: A meta-analysis
Wei Fu, Hu Fu, Weixia Ye, Yinsuo Han, Xianqiang Liu, Sirui Zhu, Hongmin Li, Rong Tang, Qin Wang
International Immunopharmacology.2021; 101: 108235. CrossRef
Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Noninvasive Predictors of the Therapeutic Outcomes of Systemic Corticosteroid Therapy in Ulcerative Colitis
Katsuya Endo, Tomonori Satoh, Yuki Yoshino, Shiho Kondo, Yoko Kawakami, Tomofumi Katayama, Yoshiteru Sasaki, Atsuko Takasu, Takayuki Kogure, Morihisa Hirota, Takayoshi Meguro, Kennichi Satoh
Inflammatory Intestinal Diseases.2021; 6(4): 218. CrossRef
Association between platelet count and mucosal healing in Japanese patients with ulcerative colitis: a cross-sectional study
Shinya Furukawa, Sen Yagi, Kana Shiraishi, Kenichirou Mori, Tomoyuki Ninomiya, Keitarou Kawasaki, Yuji Mizukami, Seiyuu Suzuki, Masayoshi Uraoka, Naozumi Shibata, Sanae Nakamura, Satoshi Imamine, Hidehiro Murakami, Katsuhisa Ohashi, Masamoto Torisu, Aki H
BMC Gastroenterology.2020;[Epub] CrossRef

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Polymorphisms in PRKCDBP, a Transcriptional Target of TNF-α, Are Associated With Inflammatory Bowel Disease in Korean: Jung-Wook Kim, Chang Kyun Lee, Hyo Jong Kim, Jae-Jun Shim, Jae Young Jang, Seok Ho Dong, Byung-Ho Kim, Young Woon Chang, Sung-Gil Chi; Intest Res 2015;13(3):242-249. Published online June 9, 2015; DOI: https://doi.org/10.5217/ir.2015.13.3.242

Abstract PDF PubReader

<b>Background/Aims</b><br/>

Emerging data indicate that polymorphic sequence variations in the tumor necrosis factor alpha (TNF-α) gene may affect its production, and be associated with the risk of inflammatory bowel disease (IBD). PRKCDBP is a putative tumor suppressor gene and a transcriptional target of TNF-α. The aim of this case-control study is to explore the possible association of single nucleotide polymorphisms (SNPs) in PRKCDBP with the development of IBD in Koreans.

Methods

Genotyping analysis of four SNPs of PRKCDBP [rs35301211 (G210A), rs11544766 (G237C), rs12294600 (C797T), and rs1051992 (T507C)] was performed on 170 ulcerative colitis (UC),131 Crohn's disease (CD) patients, and 100 unrelated healthy controls using polymerase chain reaction and restriction fragment length polymorphism.

Results

Heterozygous configuration of three SNPs (G210A, G237C, and C797T) was very rare in both patients and healthy controls. However, allele frequencies of the T507C SNP showed a significant difference between UC patients and controls (P=0.037). The CC genotype of the T507C SNP was identified in 46.6% (61 of 131) of CD and 49.4% (84 of 170) of UC patients, but only in 33.0% (33 of 100) of healthy controls. Furthermore, CC homozygosity was more prevalent than TC heterozygosity in both CD and UC patients versus controls (P=0.016; gender-adjusted odds ratio [aOR], 2.16; 95% confidence interval [CI], 1.16-4.04 and P=0.009; aOR, 2.09; 95% CI, 1.193.64; respectively)

Conclusions

Our results suggest that the T507C SNP in PRKCDBP, a TNF-α-inducible gene, might be associated with susceptibility to IBD (particularly UC) development in Koreans.

Citations

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Comprehensive analysis of key host gene-microbe networks in the cecum tissues of the obese rabbits induced by a high-fat diet
Yanhong Li, Xiaolan Qi, Qinrong Wang, Yan He, Zhupeng Li, Xi Cen, Limin Wei
Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef
IL-32 gamma reduces lung tumor development through upregulation of TIMP-3 overexpression and hypomethylation
Jaesuk Yun, Mi Hee Park, Dong Ju Son, Kyung Tak Nam, Dae Bong Moon, Jung Heun Ju, Ok Kyung Hwang, Jeong Soon Choi, Tae Hoon Kim, Young Suk Jung, Dae Yeon Hwang, Sang Bae Han, Do-Young Yoon, Jin Tae Hong
Cell Death & Disease.2018;[Epub] CrossRef
The Correlation of Serum IL-12B Expression With Disease Activity in Patients With Inflammatory Bowel Disease
Hye Won Lee, Sook Hee Chung, Chang Mo Moon, Xiumei Che, Seung Won Kim, Soo Jung Park, Sung Pil Hong, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
Medicine.2016; 95(23): e3772. CrossRef

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Case Report

Drug Rash with Eosinophilia and Systemic Symptoms Syndrome in a Patient on Sulfasalazine for Ulcerative Colitis: Kyung Hwan Kang, Chang Kyun Lee, Hyo Jong Kim, Jaejun Shim, Jae Young Jang, Seok Ho Dong, Byung Ho Kim, Young Woon Chang; Intest Res 2012;10(4):383-387. Published online October 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.4.383

Abstract PDF

Drug rash with eosinophilia and systemic symptoms (DRESS) is a life-threatening systemic drug reaction characterized by fever, rash, hematological abnormalities, lymphadenopathy, and multiple internal organ involvement. Unfortunately, a long latency period as well as clinicians' unawareness of the disease entity often results in a delay of prompt diagnosis and treatment in clinical practice. A search of the literature revealed only few reports on DRESS in patients with inflammatory bowel diseases. The pathogenesis of the disease is not clearly understood, although several possible mechanisms, such as drug detoxification, slow acetylation, and reactivation of human herpes viruses, have been proposed in its development. Here, we present a rare case of DRESS associated with viral reactivation and defects in drug metabolism in a 22-year-old man who had been on sulfasalazine for 6 weeks to treat ulcerative colitis. (Intest Res 2012;10:383-387)

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When Treatment Backfires: A Case Report of Sulfasalazine-Induced Hypersensitivity Syndrome in a Moroccan Patient With Crohn's Disease and Literature Review
Imane Zouaki, Fatimaezzahra Lairani, Hala Aouroud, Oussama Nacir, Adil Ait Errami, Sofia Oubaha, Zouhour Samlani, Khadija Krati
Cureus.2025;[Epub] CrossRef

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Original Articles

Efficacy of Infliximab Rescue Therapy in Hospitalized Patients with Steroid-Refractory Ulcerative Colitis: Single Center Experience: Jun Hyung Cho, Chang Kyun Lee, Hyo Jong Kim, Jae Jun Shim, Jae Young Jang, Seok Ho Dong, Byung Ho Kim, Young Woon Chang; Intest Res 2012;10(2):152-160. Published online April 30, 2012; DOI: https://doi.org/10.5217/ir.2012.10.2.152

Abstract PDF

Background/Aims
In hospitalized patients with acute steroid-refractory UC, infliximab has been demonstrated to be one of the medical rescue therapies to avoid colectomy. We report the result of a retrospective observational study to find the efficacy and safety of infliximab as a rescue therapy in our hospital. Methods: Between January 2007 and January 2010, 9 hospitalized patients with steroid-refractory UC were selected to receive three infusions of infliximab (5 mg/kg), at weeks 0, 2, and 6. Efficacy of treatment was evaluated at 8 weeks after the first infliximab infusion and at the end of follow-up period. Adverse events related to infliximab rescue therapy were also collected. Results: Seven patients (77.8%) had completed 3 infusions of infliximab and achieved clinical response at 8 weeks after the first infliximab infusion. Clinical remission rate and the rate of mucosal healing at 8 weeks were 57.1% (4/7) and 71.4% (5/7), respectively. They were followed up for median time of 24.9 months (19.5-53.6 months). One patient underwent emergency colectomy at weeks 2, due to colon perforation, while another patient had discontinued infliximab treatment at weeks 4, because of Clostridium difficile-associated colitis. Finally, colectomy was avoided in 77.8% (7/9) of cases. There was no mortality. Conclusions: Rescue therapy with infliximab has sustained clinical benefit in 88.9% of our hospitalized patients with acute steroid-refractory UC. Future prospective and long-term follow-up trials with a large number of patients are needed to confirm the efficacy and safety of the treatment. (Intest Res 2012;10: 0-160)

Citations

Citations to this article as recorded by

Differences in the Prognosis according to the Periods of Diagnosis in Ulcerative Colitis
Hyun Beom Chae, Yoon Suk Jung, Dong Il Park, Chang Kyun Lee, Kyu Chan Huh, Jeong Eun Shin, Jae Hak Kim, You Sun Kim, Yunho Jung, Sung Ae Jung, Hyun Ju Song, Hyun Joo Jang, Sung Noh Hong, Young-Ho Kim
The Korean Journal of Gastroenterology.2014; 64(2): 93. CrossRef

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Capsule Endoscopy for Suspected Small Bowel Bleeding in Patients with Portal Hypertension: Gang Il Cheon, Jin Oh Kim, Sung Wook Hong, Seong Ran Jeon, Tae Hee Lee, Hyun Gun Kim, Won Young Cho, Wan Jung Kim, Min Jeong Kim, Sung Won Jeong, Jae Young Jang, Bong Min Ko, Joo Young Cho, Joon Seong Lee; Intest Res 2011;9(2):129-138. Published online August 30, 2011; DOI: https://doi.org/10.5217/ir.2011.9.2.129

Abstract PDF: Background/Aims
In Korea, limited data are available on small bowel bleeding in patients with portal hypertension. This study reports on the use of capsule endoscopy in cases of suspected small bowel bleeding in patients with portal hypertension. Methods: Capsule endoscopy was used at our hospital to evaluate small bowel disease in 501 cases from July 2003 to June 2010. Of those cases, nine patients with portal hypertension due to liver cirrhosis with suspected small bowel bleeding were selected for the study. A retrospective analysis was performed using data from medical records. Results: Six of the nine (66.7%) patients were males with an average age of 53.4 years. The average hemoglobin level was 8.1 g/dL. Abnormalities noted during capsule endoscopy included portal hypertensive enteropathy in all nine cases (100%), jejunal varices in four (44.4%), jejunal and ileal angiodysplasia in five (55.5%), multiple small bowel erosions in one (11.1%), granularity of the jejunal mucosa in one (11.1%), and small bowel erythema in three (33.3%). Active bleeding from jejunal varices was detected in two patients (22.2%). Despite having no obvious active bleeding during the capsule endoscopy, four patients (44.4%) were diagnosed with portal hypertensive enteropathy with obscure small bowel bleeding. Conclusions: Capsule endoscopy is a useful diagnostic tool for the evaluation of small bowel bleeding in patients with portal hypertensive enteropathy. Additional prospective and multicenter studies on the use of capsule endoscopy are needed to evaluate the incidence and clinical importance of portal hypertensive enteropathy. (Intest Res 2011;9:129-138)

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Case Reports

Two Cases of Crohn's Disease Presented with Hematochezia in Patients with Hemophilia: Jae Hyun Park, Hyo Jong Kim, Seong Dong Sohn, Young Hwangbo, Jaejun Shim, Jae Young Jang, Seok Ho Dong, Byung Ho Kim, Young Woon Chang, Rin Chang; Intest Res 2011;9(1):35-39. Published online April 30, 2011; DOI: https://doi.org/10.5217/ir.2011.9.1.35

Abstract PDF: The etiology of Crohn's disease, which is a chronic inflammatory condition that potentially involves any location of the alimentary tract from the mouth to the anus, is unknown. However, there is strong evidence that vascular damage could play a role in the pathogenesis of Crohn's disease. Crohn's disease is mediated by multifocal gastrointestinal infarctions, which occur at an early stage in the disease process. Persistent activation of coagulation in patients with Crohn's disease has been shown. In contrast, hemophilia is an inherited disorder of coagulation. The deficiencies of clotting factors usually involve occult or overt bleeding. The pathogenic mechanisms of Crohn's disease and hemophilia are incompatible. An association between Crohn's disease and hemophilia has not been reported in Korea. We managed 21- and 33-year-old men with Crohn's disease associated with hemophilia, who presented with hematochezia. (Intest Res 2011;9: 9-39)

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Pseudo-Obstruction of Jejunum due to AA Amyloidosis Associated with Latent Syphilis: Young Hwangbo, Hyo Jong Kim, Jae Yeon Lee, Jae Young Jang, Seok Ho Dong, Byung Ho Kim, Young Woon Chang, Rin Chang; Intest Res 2010;8(2):195-199. Published online December 30, 2010; DOI: https://doi.org/10.5217/ir.2010.8.2.195

Abstract PDF: Amyloidosis uncommonly presents with intestinal pseudo-obstruction. According to previous reports, patients with primary AL amyloidosis presented with a chronic process with symtom duration of more than 1 year, but patients with secondary AA amyloidosis presented as an acute illness, usually less than 10 weeks. Localized gastrointestinal amyloidosis limited to the jejunum, without involvement of stomach, duodenum, colon, or rectum, is very rare. Imaging studies in small intestinal amyloidosis generally show a symmetrical uniform appearance. AA amyloidosis with acute-phase reactant serum amyloid A protein is associated with inflammatory, infectious or neoplastic disorders. To our knowledge, no case of amyloidosis associated with latent syphilis has been reported to date. We present a case of a 56-year-old man who presented with clinical and radiographic features of a small bowel obstruction and obscure gastrointestinal bleeding. Investigations including laparoscopy and other laboratory dataled to a diagnosis of pseudo-obstruction of the jejunum due to AA amyloidosis associated with latent syphilis. After appropriate treatment for latent syphilis, abdominal symptoms had been disappeared, but jejunal dilatation was still present two years later. (Intest Res 2010;8:195-199)

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Original Article

Change of Circulating Leptin, Adiponectin, Resistin, and Visfatin Level after Treatment of Patients with Active Inflammatory Bowel Disease: Young Hwangbo, Hyo Jong Kim, Jaejun Shim, Jae Young Jang, Seok Ho Dong, Byung Ho Kim, Young Woon Chang; Intest Res 2010;8(2):151-161. Published online December 30, 2010; DOI: https://doi.org/10.5217/ir.2010.8.2.151

Abstract PDF

Background/Aims
The aim of this study was to evaluate the change in circulating levels of adipokines, including leptin, adiponectin, resistin, and visfatin, after induction therapy of patients with active inflammatory bowel disease (IBD). Methods: We prospectively evaluated 20 patients with Crohn's disease (CD) and 14 patients with ulcerative colitis (UC) who received induction therapy. The disease activity, body mass index (BMI), and C-reactive protein (CRP) and serum adipolines levels were checked before treatment and 10 weeks after treatment. Results: After induction therapy, significant reduction of disease activity was noted in patients with CD (CD activity index, 267.9±73.7 vs. 50.8±36.5, P＜0.001) and patients with UC (Mayo score, 9.8±2.2 vs. 1.4±1.6, P＜0.001). The mean serum leptin, adiponectin, resistin, and visfatin levels were 4.0±2.7 ng/mL and 4.4±2.3 ng/mL (P=0.323), 27.0±20.5 Ռg/mL and 33.8±26.5Ռg/mL (P=0.084), 9.0±4.0 ng/mL and 10.2±3.2 ng/mL (P=0.108), and 4.6±3.7 ng/mL and 2.5±4.1 ng/mL (P=0.046) before and after infliximab treatment, respectively. No significant correlation between the changes in BMI, CRP level, or the clinical indices of activity and alterations of the measured adipokines was demonstrated. Conclusions: The serum levels of leptin, adiponectin, and resistin showed no significant alterations, whereas the serum visfatin level decreased significantly after induction therapy, suggesting a possible pro-inflammatory property of visfatin and a role as a marker of successful therapy of IBD. (Intest Res 2010;8:151-161)

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Circulating Ghrelin Levels and Obestatin/Ghrelin Ratio as a Marker of Activity in Ulcerative Colitis
Ja Young Jung, Ji Bong Jeong, Ji Won Kim, Su Hwan Kim, Seong-Joon Koh, Byeong Gwan Kim, Kook Lae Lee
Intestinal Research.2015; 13(1): 68. CrossRef

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Case Report

A Case of Sigmoidorectal Intussusception after Self-Expandable Colonic Stent Placement: Chang Kyun Lee, Hyo Jong Kim, Jae Young Jang, Seok Ho Dong, Byung-Ho Kim, Young Woon Chang, Rin Chang, Hyoung Jung Kim, Kil Yeon Lee; Intest Res 2008;6(1):70-75. Published online June 30, 2008

Abstract PDF: Self-expandable metallic stents are widely used to relieve acute colorectal obstruction that's secondary to malignancy. They are utilized for both palliation and preoperative decompression prior to colorectal surgery. Although stents have been documented as a relatively safe therapeutic modality, procedure-related complications such as perforation, bleeding, stent reobstruction and migration can occur during or after colonic stent placement. Therefore, clinicians must be aware of the various complications associated with colonic stent placement. We present here a very rare case of sigmoidorectal intussusception that developed after fluoroscopic placement of a self-expandable metallic stent for preoperative decompression of sigmoid colon cancer. We misdiagnosed the intussusception as a distal stent migration on the plain radiography. On the sigmoidoscopic examination to evaluate the unrelieved colonic obstruction, we diagnosed a sigmoidorectal intussusception of the stent-implanted malignant tumor. The patient was successfully treated by laparoscopic partial reduction, followed by a curative anterior resection. This case demonstrates that careful examination must be done in cases of unrelieved colonic obstruction with suspicious stent migration, and intussusception must be considered as a rare complication of self-expandable metallic stent placement in the colon. (Intest Res 2008;6:70-75)

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Original Articles

A Roles of Apoptotic Genes in Colon Cancers: Jae Young Jang, Hyo Jong Kim, Sung-Gil Chi, Kil Yeon Lee, Ki Deuk Nam, Nam Hoon Kim, Sang Kil Lee, Kwang Ro Joo, Seok Ho Dong, Byung-Ho Kim, Young Woon Chang, Joung Il Lee, Rin Chang; Intest Res 2004;2(2):71-76. Published online December 22, 2004

Abstract PDF: Badkground/Aims: X-linked inhibitor of apoptosis (XIAP) is the most potent member of the IAP family that exerts antiapoptotic effects. Recently, XIAP-associated factor 1 (XAF1) and two mitochondrial proteins, Smac/DIABLO and HtrA2, have been identified to negatively regulate the caspase-inhibiting activity of XIAP. We explored the candidacy of XAF1, Smac/DIABLO and HtrA2 as a tumor suppressor in colonic carcinogenesis. Methods: The expression and mutation status of the genes were assessed in 10 colorectal carcinoma cell lines. Results: XAF1 transcript was not expressed or present at extremely low levels in 60% (6/10) of cancer cell lines whereas Smac/DIABLO and HtrA2 are normally expressed in all cell lines examined. XAF1 transcript was reactivated in all low expressor cell lines by treatment with the demethylating agent 5-aza-2'-deoxycytidine. Moreover, bisulfite DNA sequencing analysis for 34 CpG sites in the promoter region revealed a strong association between hypermethylation and gene silencing. Restoration of XAF1 expression resulted in enhanced apoptotic response to etoposide and 5-flurouracil. Conclusions: XAF1 undergoes epigenetic gene silencing in a considerable proportion of human colon cancers by aberrant promoter hypermethylation, suggesting that XAF1 inactivation might be implicated in colonic tumorigenesis. (Intestinal Research 2004;2:71-76)

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Bioflor^Ⱂ Suppresses Expression of Interleukin-8 in HT-29 cell: Sang Kil Lee, Hyo Jong Kim, Sung Gil Chi, Jae Young Jang, Ki Deok Nam, Nam Hoon Kim, Kwang Ro Joo, Seok Ho Dong, Byung Ho Kim, Young Woon Chang, Joung Il Lee, Rin Chang; Intest Res 2004;2(2):96-101. Published online December 22, 2004

Abstract PDF: Background/Aims
Nowadays, there is a growing interest in probiotics as a safe way of changing the intestinal bacterial flora. Probiotics may have potential in several gastroenterological conditions. The nonpathogenic yeast, Saccharomyces boulardii (S. boulardii, Bioflor^Ⱂ), has been used empirically in the treatment of acute infectious diarrhea and antibiotics-associated diarrhea. Recently, S. boulardii was reported to be beneficial in the treatment of inflammatory bowel disease, however, little is known about their mechanisms of action. We examined the ability of S. boulardii to modulate inflammatory response in human colon cells. Methods: Effects of Bioflor^Ⱂ on survival and proliferation of HT-29 human colon cells were assessed by MTT and [3H]thymidine incorporation assays. Interleukin-8 (IL-8) expression was stimulated with tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), or lipopolysacharide (LPS). IL-8 was assessed by RT-PCR. Results: Bioflor^Ⱂ did not affect viability and proliferation of HT-29 cell. Pretreatment of HT-29 cells with Bioflor^Ⱂ blocked IL-8 up-regulation by TNF-α, IL-1β, or LPS to these proinflammatory factors. Conclusions: Bioflor^Ⱂ reduces responses to proinflammatory cytokines in human colon cells. (Intestinal Research 2004;2:96-101)

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