Intestinal Research

Statement

Cancer

Clinical practice guideline for endoscopic resection of early gastrointestinal cancer: Chan Hyuk Park, Dong-Hoon Yang, Jong Wook Kim, Jie-Hyun Kim, Ji Hyun Kim, Yang Won Min, Si Hyung Lee, Jung Ho Bae, Hyunsoo Chung, Kee Don Choi, Jun Chul Park, Hyuk Lee, Min-Seob Kwak, Bun Kim, Hyun Jung Lee, Hye Seung Lee, Miyoung Choi, Dong-Ah Park, Jong Yeul Lee, Jeong-Sik Byeon, Chan Guk Park, Joo Young Cho, Soo Teik Lee, Hoon Jai Chun; Intest Res 2021;19(2):127-157. Published online October 13, 2020; DOI: https://doi.org/10.5217/ir.2020.00020

Abstract PDF Supplementary Material PubReader ePub

Although surgery was the standard treatment for early gastrointestinal cancers, endoscopic resection is now a standard treatment for early gastrointestinal cancers without regional lymph node metastasis. High-definition white light endoscopy, chromoendoscopy, and image-enhanced endoscopy such as narrow band imaging are performed to assess the edge and depth of early gastrointestinal cancers for delineation of resection boundaries and prediction of the possibility of lymph node metastasis before the decision of endoscopic resection. Endoscopic mucosal resection and/or endoscopic submucosal dissection can be performed to remove early gastrointestinal cancers completely by en bloc fashion. Histopathological evaluation should be carefully made to investigate the presence of risk factors for lymph node metastasis such as depth of cancer invasion and lymphovascular invasion. Additional treatment such as radical surgery with regional lymphadenectomy should be considered if the endoscopically resected specimen shows risk factors for lymph node metastasis. This is the first Korean clinical practice guideline for endoscopic resection of early gastrointestinal cancer. This guideline was developed by using mainly de novo methods and encompasses endoscopic management of superficial esophageal squamous cell carcinoma, early gastric cancer, and early colorectal cancer. This guideline will be revised as new data on early gastrointestinal cancer are collected.

Citations

Citations to this article as recorded by

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Lihua Guo, Yong Ding, Jinfeng Wen, Min Miao, Kefeng Hu, Guoliang Ye
World Journal of Surgical Oncology.2025;[Epub] CrossRef
High Frequency of RhoGAP Fusion and Muscularis Mucosae Invasion in pT1a Gastric Adenocarcinoma Harboring Lymph Node Metastasis
Chiina Hata, Hiroto Noda, Kaoru Nakano, Seiji Sakata, Kazuma Moriya, Satoko Baba, Toshiaki Hirasawa, Manabu Takamatsu, Emiko Sugawara, Noriko Yamamoto, Souya Nunobe, Takuji Gotoda, Kenichi Ohashi, Kengo Takeuchi, Hiroshi Kawachi
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D. H. Kim, B. C. Jin, H. H. Oh, H. Y. Song, S. J. Kim, D. S. Myung, H. S. Kim, S. W. Kim, J. Lee, Y. E. Joo, G. S. Seo
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Zhenghua Piao, Rong Ge, Chunnian Wang
International Journal of Colorectal Disease.2023;[Epub] CrossRef
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Valli De Re, Stefano Realdon, Roberto Vettori, Alice Zaramella, Stefania Maiero, Ombretta Repetto, Vincenzo Canzonieri, Agostino Steffan, Renato Cannizzaro
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The Korean Journal of Gastroenterology.2023; 82(2): 47. CrossRef
Effectiveness and Safety of Endoscopic Submucosal Dissection for Colorectal Neoplasm in Patients with High Charlson Comorbidity Index Score: A HASID Multicenter Study
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Endoscopic management of pseudo-lumen stapling following laparoscopic esophagojejunostomy: A case report
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Jihun Jang, Jihye Park, Soo Jung Park, Jae Jun Park, Jae Hee Cheon, Tae Il Kim
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Yoon Suk Jung
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Prognosis and risk factors of electrocoagulation syndrome after endoscopic submucosal dissection in the colon and rectum. Large cohort study
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Yu Mi Lee, Kyung Ho Song, Hoon Sup Koo, Choong-Sik Lee, Inseok Ko, Sang Hyuk Lee, Kyu Chan Huh
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Ji Young Chang
Clinical Endoscopy.2022; 55(5): 699. CrossRef
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Jing Wang, Shi-Jie Li, Yan Yan, Peng Yuan, Wei-Feng Li, Chang-Qi Cao, Wei-Gang Chen, Ke-Neng Chen, Qi Wu
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Darina Kohoutova, Matthew Banks, Jan Bures
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29 Web of Science
24 Crossref

Case Reports

Colorectal neoplasia

Primary malignant melanoma without melanosis of the colon: Nam Hee Yi, Sang Heon Lee, Sang Heon Lee, Ji Hyun Kim, Sam Ryong Jee, Sang Yong Seol; Intest Res 2019;17(4):561-564. Published online August 5, 2019; DOI: https://doi.org/10.5217/ir.2019.00020

Abstract PDF PubReader ePub

Primary malignant melanoma (PMM) of the gastrointestinal tract is rare. Reported cases of PMM of the lower gastrointestinal tract typically describe anal and rectal involvement rather than colonic lesions. This report describes a rare case of a 50-year-old woman with PMM originating in the colon. The patient presented to Inje University Busan Paik Hospital with a 3-day history of blood-tinged stools. She underwent colonoscopy for a diagnosis of hematochezia. The colonoscopic examination revealed a large-sized semi-pedunculated sigmoid colon polyp with a reddish-colored mucosal surface. Endoscopic mucosal resection was performed, and the final histopathological findings were consistent with a diagnosis of malignant melanoma. Systemic work-up was performed for assessment of metastasis and to identify the primary tumor considering the high metastatic rate of gastrointestinal malignant melanoma; however, no other malignant lesion was detected. Thus, she was diagnosed with colonic PMM. She underwent laparoscopic low anterior resection and lymph node dissection and has been recurrence-free for > 2 years.

Citations

Citations to this article as recorded by

Primary melanoma of the gastrointestinal tract
Paola De Nardi, Stefania Guida, Giuseppe Damiano, Nathalie Rizzo, Ana Maria Samanes Gajate, Silvia Teresa Riva, Giovanni Paolino, Michele Colombo, Roberta Tummineri, Franco Rongioletti, Santo Raffaele Mercuri, Arturo Chiti, Pierpaolo Sileri, Vincenzo Russ
World Journal of Gastroenterology.2026;[Epub] CrossRef
Malignant primary melanoma of the colon: a case report
Claire K Foley, Marybeth S Hughes, Charles T Hehman
Journal of Surgical Case Reports.2023;[Epub] CrossRef

8,119 View
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4 Web of Science
2 Crossref

IBD

Duodenal amyloidosis secondary to ulcerative colitis: Seung Woon Park, Sam Ryong Jee, Ji Hyun Kim, Sang Heon Lee, Jin Won Hwang, Ji Geon Jang, Dong Woo Lee, Sang Yong Seol; Intest Res 2018;16(1):151-154. Published online January 18, 2018; DOI: https://doi.org/10.5217/ir.2018.16.1.151

Abstract PDF PubReader ePub

Amyloidosis is defined as the extracellular deposition of non-branching fibrils composed of a variety of serum-protein precursors. Secondary amyloidosis is associated with several chronic inflammatory conditions, such as rheumatologic or intestinal diseases, familial Mediterranean fever, or chronic infectious diseases, such as tuberculosis. Although the association of amyloidosis with inflammatory bowel disease is known, amyloidosis secondary to ulcerative colitis (UC) is rare. A 36-year-old male patient with a 15-year history of UC presented with nausea, vomiting, and abdominal pain. He had been treated with infliximab for 6 years. At the time of admission, he had been undergoing treatment with mesalazine and adalimumab since the preceding 5 months. Esophagogastroduodenoscopy showed mucosal erythema, edema, and erosions with geographic ulcers at the 2nd and 3rd portions of the duodenum. Duodenal amyloidosis was diagnosed using polarized light microscopy and Congo red stain. Monoclonal gammopathy was not detected in serum and urine tests, while the serum free light chain assay result was not specific. An increase in plasma cells in the bone marrow was not found. Secondary amyloidosis due to UC was suspected. The symptoms were resolved after glucocorticoid therapy.

Citations

Citations to this article as recorded by

Idiopathic AA amyloidosis presenting with initial abdominal pain: a case report and literature review
Pianpian Xia, Deliang Liu, Feihong Deng, Dalian Ou, Mingyang Deng
Frontiers in Medicine.2025;[Epub] CrossRef
Gastrointestinal amyloidosis in a 50‐year‐old patient with miliary tuberculosis: A case report
Sameer Abdul Rauf, Hussain Haider Shah, Rahul Khatri, Mansoor Ul Haq, Tirth Dave, Javaria Parwez Ali, Syed Khizar Ali
Clinical Case Reports.2024;[Epub] CrossRef
Therapeutic effects of biological treatments on AA amyloidosis associated with inflammatory bowel disease: a case report and literature review
Marouf Alhalabi, Kamal Alaa Eddin, Ahmad Abbas
European Journal of Gastroenterology & Hepatology.2023; 35(11): 1298. CrossRef
Rheumatoid arthritis: Extra-articular manifestations and comorbidities
Fabiana Assunta Figus, Matteo Piga, Irene Azzolin, Rebecca McConnell, Annamaria Iagnocco
Autoimmunity Reviews.2021; 20(4): 102776. CrossRef
Specific Clinical and Morphological Characteristics of Amyloidosis of the Stomach and Duodenum
Z. V. Gioeva, L. M. Mikhaleva
Journal of Anatomy and Histopathology.2019; 8(1): 39. CrossRef
Morphological and Immunohistochemical Characteristics of Experimental Mandibular Fractures Healing Process
A. A. Matchin, A. A. Stadnikov, E. V. Nosov, S. Kh. Kiriakidi
Journal of Anatomy and Histopathology.2019; 8(1): 44. CrossRef
Secondary, AA, Amyloidosis
Riccardo Papa, Helen J. Lachmann
Rheumatic Disease Clinics of North America.2018; 44(4): 585. CrossRef

9,374 View
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6 Web of Science
7 Crossref

Rare Case of Ogilvie Syndrome Associated with Herpes Zoster: Ji Hyun Kim, Suck-Ho Lee, Gyeong Jae Na, Su Jin Lee, Yeong Geol Jo, Tae Hoon Lee, Il Kwun Chung, Sang Heum Park, Sun Joo Kim; Intest Res 2012;10(4):379-382. Published online October 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.4.379

Abstract PDF

Acute colonic pseudo-obstruction (Ogilvie syndrome) associated with herpes zoster is extremely rare, and few cases have been reported. An 81-year-old woman diagnosed with herpes zoster was referred for accompanying colonic ileus. The diameter of the cecum was 7 cm and a computed tomographic scan showed no definite obstructive cause. Because the patient showed minimal improvement with conservative treatment, endoscopic colonic decompression was performed successfully. Previous studies revealed that the treatment of Ogilvie syndrome associated with herpes zoster does not differ from that of other conditions, and the role of the varicella-zoster virus in this syndrome is unclear. Here, we present the first case of Ogilvie syndrome associated with herpes zoster in Korea, which was improved by endoscopic colonic decompression. (Intest Res 2012;10:379-382)

Citations

Citations to this article as recorded by

Looking back to move forward: a twenty-year audit of herpes zoster in Asia-Pacific
Liang-Kung Chen, Hidenori Arai, Liang-Yu Chen, Ming-Yueh Chou, Samsuridjal Djauzi, Birong Dong, Taro Kojima, Ki Tae Kwon, Hoe Nam Leong, Edward M. F. Leung, Chih-Kuang Liang, Xiaohong Liu, Dilip Mathai, Jiun Yit Pan, Li-Ning Peng, Eduardo Rommel S. Poblet
BMC Infectious Diseases.2017;[Epub] CrossRef
Acute Colonic Pseudo-Obstruction (Ogilvie’s syndrome) as a Complication of Herpes Zoster
Kyung-Sun Min
The Korean Journal of Medicine.2016; 90(4): 318. CrossRef

3,452 View
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2 Crossref

A Case of Mixed Hyperplastic-adenomatous Rectal Polyp with Composition of Invasive Adenocarcinoma: Hyo Rim Seo, Ji Hyun Kim, Soo Jin Jung, Yun Jung Choi, Choong Heon Ryu, Kwan Sik Park, Seoung In Ha, Eun Uk Jung, Sang Heon Lee, Sung Jae Park, Jung Sik Choi, Sam Ryong Jee, Youn Jae Lee, Sang Young Seol; Intest Res 2012;10(3):295-299. Published online July 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.3.295

Abstract PDF: Epithelial colon polyps are largely divided into hyperplastic and adenomatous polyps. Adenomatous polyps are premalignant lesions, whereas hyperplastic polyps are regarded as benign lesions. However, this histological classification has been blurred, as cases of malignant changes in hyperplastic polyposis, mixed hyperplastic adenomatous polyps (MHAPs), and serrated adenomas in the colon have been reported. Rare cases of MHAP have been reported, and are mainly found at the proximal colon with a relatively large size. MHAPs seem to be an intermediate stage of the hyperplastic polyp-adenoma sequence or a collision tumor. Here, we report on a case of a single polyp in the rectum diagnosed with a MHAP combined with an invasive adenocarcinoma. (Intest Res 2012;10: 0-299)

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Original Articles

The Characteristics of Colonoscopic Findings in Differentiating Crohn's Disease from Intestinal Tuberculosis: In Soo Je, Sang Hyuk Lee, Eun Uk Jung, Myoung Joo Kang, Sang Won Park, Paul Choi, Ji Hyun Kim, Sung Jae Park, Sam Ryong Jee, Eun Taek Park, Youn Jae Lee, Sang Yong Seol; Intest Res 2007;5(2):158-164. Published online December 30, 2007

Abstract PDF: Background/Aims
The incidence of Crohn's disease (CD) is on the increase in Korea. The differentiation of Crohn's disease from intestinal tuberculosis (IT) is difficult. The aim of this study is to determine the characteristics of colonoscopic findings and factors that differentiate CD from IT. Methods: A total of 136 patients who were diagnosed with CD or IT at the Busan Paik Hospital from January 1995 to May 2005 were included in this study. We analyzed endoscopic findings, clinical characteristics and histological findings of 75 patients with CD and 61 patients with IT retrospectively. Results: For patients with IT, 18 (58.1%) of the patients had circular ulcers. For patients with CD, 27 (42.1%) of the patients had transverse ulcers, 18 (28.1%) of the patients had longitudinal ulcer, and 19 (29.6%) of the patients had both types of ulcers. The involvement of the ileocecal valve was noted in 18 (58.0%) of the patients with CD and in 37 (57.8%) of the patients with IT. The involvement of the rectum or anus was noted in 24 (51.5%) of the patients with CD and one (3.2%) patient with IT. Conclusions: According to previous studies, the presence of an ulcer was important to differentiate CD from IT. However, the presence of an ulcer was not a significant differentiating factor in our study. On colonoscopic findings, involved segments, an aphthous ulcer, cobblestone appearance, involvement of the rectum or anus and mucosal bridge should be observed carefully. (Intest Res 2007;5:158-164)

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Clinical Analysis of Sigmoid Volvulus: Ji Hyun Kim, Jin Yong Kim, Kwan An Kwon, Moon Gi Chung, Jong Eun Yeon, Jong-Jae Park, Jae Seon Kim, Kwan Soo Byun, Young-Tae Bak; Intest Res 2005;3(2):117-120. Published online December 30, 2005

Abstract PDF: Background/Aims
Sigmoid volvulus is a rare cause of large bowel obstruction, but can lead to significant morbidity, but there have been few recent studies in Korea. This study was undertaken to evaluate the clinical features of sigmoid volvulus. Methods: We retrospectively reviewed the medical records of 11 patients diagnosed as a sigmoid volvulus in Korea university Guro, Ansan, Anam hospital and Gachon medical school Gil medical center from January 2000 to February 2005 and investigated their demographics, clinical course and outcomes. Results: The mean age was 34 years (range 25-58) and the male：female ratio was 6：5. Endoscopic decompression was attempted in 10 of 11 patients and was successful in all of them. 4 of them were undergone elective surgery and 1 of them developed recurrent sigmoid volvulus. 1 patient died by sepsis and total 4 patients developed recurrent volvulus. Conclusions: The mean age was relatively young compared with previously reported cases. Initial endoscopic decompression resolves the acute obstruction in the all of cases and recurrent rate was 40% and mortality rate was 9%. (Intestinal Research 2005;3:117-120)

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