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Case Report
A Case of Localized Amyloid Light-Chain Amyloidosis in the Small Intestine
Jong Hyo Choi, Bong Min Ko, Cheol Kim, Hee Kyung Kim, Jae Pil Han, Su Jin Hong, Jong Ho Moon, Moon Sung Lee
Intest Res 2014;12(3):245-250.   Published online July 25, 2014
DOI: https://doi.org/10.5217/ir.2014.12.3.245
AbstractAbstract PDFPubReaderePub

Amyloidosis is characterized by the abnormal deposition of extracellular amyloid fibrils. Cases involving amyloid light-chain amyloidosis in the small intestine have been reported infrequently in Korea. Here, we report a case of localized light chain protein amyloidosis in the small intestine. Esophagogastroduodenoscopy, push enteroscopy, and capsule endoscopy revealed submucosal tumor-like lesions, multiple shallow ulcers, and several erosions in the distal duodenum and jejunum. An endoscopic biopsy established the diagnosis of amyloidosis. In through an immunohistochemical analysis, the presence of lambda light chain protein was detected. The patient had no evidence of an underlying clonal plasma cell disorder or additional organ involvement. Therefore, we concluded that the patient had localized amyloidosis of the small intestine.

Citations

Citations to this article as recorded by  
  • A systematic review of the literature on localized gastrointestinal tract amyloidosis: Presentation, management and outcomes
    Mariuxi Alexandra Viteri Malone, David Alfonso Alejos Castillo, Heitor Tavares Santos, Anahat Kaur, Tarek Elrafei, Lewis Steinberg, Abhishek Kumar
    European Journal of Haematology.2024; 113(4): 400.     CrossRef
  • Iatrogenic Sigma Perforation in a Patient with Localized Rectal and Sigma AL Amyloidosis: A Forensic Case and a Literature Review
    Giuseppe Davide Albano, Stefania Zerbo, Simone Di Franco, Elisabetta Orlando, Eleonora Formisano, Antonina Argo, Beatrice Belmonte
    Forensic Sciences.2024; 4(3): 453.     CrossRef
  • Systemic Immunoglobulin Light Chain Amyloidosis Involving the Large Intestine
    Renugadevi Swaminathan, Samuel Igbinedion, Sudha Pandit
    ACG Case Reports Journal.2021; 8(5): e00578.     CrossRef
  • Unusual case of amyloidosis presenting as a jejunal mass
    Sachin Mohan, Elliot Graziano, James Campbell, Irshad H Jafri
    BMJ Case Reports.2021; 14(5): e240226.     CrossRef
  • Gastrointestinal AA amyloidosis secondary to chronic pyelonephritis presenting with refractory diarrhea and severe hypoalbuminemia
    Tomoko Tanaka, Tatsushi Naito, Yohei Midori, Takuto Nosaka, Kazuto Takahashi, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Yoshiaki Imamura, Osamu Yokoyama, Hironobu Naiki, Yasunari Nakamoto
    Clinical Journal of Gastroenterology.2021; 14(6): 1642.     CrossRef
  • Morphological and Immunohistochemical Characteristics of Experimental Mandibular Fractures Healing Process
    A. A. Matchin, A. A. Stadnikov, E. V. Nosov, S. Kh. Kiriakidi
    Journal of Anatomy and Histopathology.2019; 8(1): 44.     CrossRef
  • Specific Clinical and Morphological Characteristics of Amyloidosis of the Stomach and Duodenum
    Z. V. Gioeva, L. M. Mikhaleva
    Journal of Anatomy and Histopathology.2019; 8(1): 39.     CrossRef
  • Localized Gastrointestinal ALλ Amyloidosis
    Tomoya Iida, Kentaro Yamashita, Hiroshi Nakase
    Clinical Gastroenterology and Hepatology.2018; 16(9): e93.     CrossRef
  • Small Bowel Amyloidosis
    Raghav Bansal, Umer Syed, Jacob Walfish, Joshua Aron, Aaron Walfish
    Current Gastroenterology Reports.2018;[Epub]     CrossRef
  • Systemic amyloidosis with gastrointestinal involvement: Diagnosis from endoscopic and histological views
    Tomoya Iida, Hiroo Yamano, Hiroshi Nakase
    Journal of Gastroenterology and Hepatology.2018; 33(3): 583.     CrossRef
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Original Articles
Clinical Review about Colon Perforation Complicated Diagnostic or Therapeutic Colonoscopy
Song Won Jung, Chang Beom Ryu, Yon Soo Kim, Min Soo Song, Bong Min Ko, Sang Woo Cha, Kwon Ho You, Soo Jin Hong, Young Seok Kim, Jong Ho Moon, Moon Sung Lee, Chan Sup Shim, Boo Sung Kim
Intest Res 2004;2(1):21-25.   Published online April 16, 2004
AbstractAbstract PDF
Colonoscopy is used increasingly because the indication for therapeutic colonoscopy has been increased and the technique has been developed continuously as well as colonosopy is useful for diagnosis of colonic disease. Therefore, It is important understanding precisely about the complication of colonoscopy and managing the complication immediately and properly. In particular, colon perforation is the most fatal, emergency case and have needed surgical treatment, generally. Recently, the case treated with endoscopic clipping and conservative management has been reported. but until now, when perforated, wheather the endoscopic clipping or the surgical management at each other case is beneficial is not confirmed. (Intestinal Research 2004;2:21-25)
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  • 27 Download
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Usefulness of Follow-up Colonoscopy in Laterally Spreading Tumor Resected by Endoscopic Piecemeal Mucosal Resection
Hwan Yeol Kim, Bong Min Ko, Sang Woo Cha, Kye Won Kwon, Soo Jin Hong, Chang Beom Ryu, Young Seok Kim, Jong Ho Moon, Jin Oh Kim, Joo Young Cho, Joon Sung Lee, Moon Sung Lee, Chan Sup Shim, Boo Sung Sung Kim
Intest Res 2003;1(2):186-191.   Published online November 27, 2003
AbstractAbstract PDF
Background/Aims
Laterally spreading tumors (LST) of the colon are defined as tumors over 10 mm in diameter that are low in height and grow superficially. These tumors are highly malignant and usually mucosal lesions, therefore endoscopic mucosal resection is desirable. We analysed retrospectively the result of endoscopic piecemeal mucosal resection (EPMR) in LSTs larger than 20 mm in diameter. Methods: 21 patients with LSTs larger than 20 mm in diameter were treated using EPMR. The resection sites were examined for residual or recurrent lesions by follow-up colonoscopy. Results: Of the 21 patients who underwent EPMR, 2 patients performed surgical resection and 4 patients were lost during follow-up period. Residual or recurrent lesions were detected in 5 of these 15 patients after EPMR. After additional endoscopic therapy, no more residual or recurrent lesions were detected. Conclusions: After EPMR for large LSTs, it is necessary to strictly follow-up at least within 1 year. (Intestinal Research 2003;2:186-191)
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  • 19 Download
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