Intestinal Research

Original Articles

High C-reactive protein level is associated with high-risk adenoma: Hyae Min Lee, Jae Myung Cha, Jung Lok Lee, Jung Won Jeon, Hyun Phil Shin, Kwang Ro Joo, Jin Young Yoon, Joung Il Lee; Intest Res 2017;15(4):511-517. Published online October 23, 2017; DOI: https://doi.org/10.5217/ir.2017.15.4.511

Background/Aims

There is substantial evidence supporting a role of inflammation in the pathogenesis of colorectal cancer; however, little is known about the association between serum C-reactive protein (CRP) and the risk of colorectal adenoma. This study was conducted to investigate the association between serum CRP and colorectal adenoma risk.

Methods

A retrospective cross-sectional study was performed on first-time screening colonoscopies in asymptomatic subjects who also had their serum CRP level measured during a routine health check-up between September 2006 and September 2009 in Korea. Serum CRP level was compared between high-risk and low-risk adenoma groups and independent predictors of high-risk adenoma were analyzed using multivariate regression analysis.

Results

Among the 3,309 eligible patients, the high-risk adenoma group had higher serum CRP levels than the low-risk adenoma group (P=0.000). In addition, patients with a high-risk adenoma were more frequently included in the high CRP group than in the low CRP group (8.6% vs. 4.0%, P<0.001). The prevalence of high-risk adenoma was 3.5 times higher in the highest quartile of CRP level (P=0.000) compared with that in the lowest quartile. In logistic regression analysis, a higher quartile CRP level was found to be an independent risk factor for high-risk adenoma (odds ratio, 1.8; 95% confidence interval, 1.3–2.5; P=0.000).

Conclusions

High CRP level is associated with high-risk adenoma in both men and women. Our data may support the association between chronic inflammation and colorectal neoplasia, which warrants further investigation.

Citations

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Short-term and residential exposure to air pollution: Associations with inflammatory biomarker levels in adults living in northern France
Marion Darras-Hostens, Djamal Achour, Manon Muntaner, Céline Grare, Gianni Zarcone, Guillaume Garçon, Philippe Amouyel, Farid Zerimech, Régis Matran, Jean-Marc Lo Guidice, Luc Dauchet
Science of The Total Environment.2022; 833: 154985. CrossRef
Functional Plasmon-Activated Water Increases Akkermansia muciniphila Abundance in Gut Microbiota to Ameliorate Inflammatory Bowel Disease
Chun-Chao Chang, Chih-Yi Liu, I-Chia Su, Yuarn-Jang Lee, Hsing-Jung Yeh, Wen-Chao Chen, Chih-Jui Yu, Wei-Yu Kao, Yu-Chuan Liu, Chi-Jung Huang
International Journal of Molecular Sciences.2022; 23(19): 11422. CrossRef
Self-reported Metabolic Risk Factor Associations with Adenomatous, Sessile Serrated, and Synchronous Adenomatous and Sessile Serrated Polyps
Celina N. Santiago, Samara Rifkin, Julia Drewes, Gerard Mullin, Emma Spence, Linda M. Hylind, Joell J. Gills, David Kafonek, David M. Cromwell, Louis La Luna, Francis Giardello, Cynthia L. Sears
Cancer Prevention Research.2021; 14(7): 697. CrossRef
Single‐incision laparoscopic colectomy for ascending colon tumor with relapsing polychondritis
Ryugo Teranishi, Norikatsu Miyoshi, Kansuke Kido, Masayuki Nishide, Shiki Fujino, Takayuki Ogino, Hidekazu Takahashi, Mamoru Uemura, Chu Matsuda, Tsunekazu Mizusima, Masaki Mori, Yuichiro Doki
Asian Journal of Endoscopic Surgery.2020; 13(4): 569. CrossRef
Increased Th17-Related Cytokine Serum Levels in Patients With Multiple Polyps of Unexplained Origin
Miren Alustiza, Eva Hernández-Illán, Miriam Juárez, Mar Giner-Calabuig, Cristina Mira, Alejandro Martínez-Roca, Luis Bujanda, Francisco Rodríguez-Moranta, Joaquín Cubiella, Luisa de-Castro, José-Carlos Marín-Gabriel, Alberto Herreros-de-Tejada, Fernando F
Clinical and Translational Gastroenterology.2020; 11(3): e00143. CrossRef

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Determining the optimal surveillance interval after a colonoscopic polypectomy for the Korean population?: Jung Lok Lee, Jae Myung Cha, Hye Min Lee, Jung Won Jeon, Min Seob Kwak, Jin Young Yoon, Hyun Phil Shin, Kwang Ro Joo, Joung Il Lee, Dong Il Park; Intest Res 2017;15(1):109-117. Published online January 31, 2017; DOI: https://doi.org/10.5217/ir.2017.15.1.109

Abstract PDF PubReader ePub

Background/Aims

Western surveillance strategies cannot be directly adapted to the Korean population. The aim of this study was to estimate the risk of metachronous neoplasia and the optimal surveillance interval in the Korean population.

Methods

Clinical and pathological data from index colonoscopy performed between June 2006 and July 2008 and who had surveillance colonoscopies up to May 2015 were compared between low- and high-risk adenoma (LRA and HRA) groups. The 3- and 5-year cumulative risk of metachronous colorectal neoplasia in both groups were compared.

Results

Among 895 eligible patients, surveillance colonoscopy was performed in 399 (44.6%). Most (83.3%) patients with LRA had a surveillance colonoscopy within 5 years and 70.2% of patients with HRA had a surveillance colonoscopy within 3 years. The cumulative risk of metachronous advanced adenoma was 3.2% within 5 years in the LRA group and only 1.7% within 3 years in the HRA group. The risk of metachronous neoplasia was similar between the surveillance interval of <5 and ≥5 years in the LRA group; however, it was slightly higher at surveillance interval of ≥3 than <3 years in the HRA group (9.4% vs. 2.4%). In multivariate analysis, age and the ≥3-year surveillance interval were significant independent risk factors for metachronous advanced adenoma (P=0.024 and P=0.030, respectively).

Conclusions

Patients had a surveillance colonoscopy before the recommended guidelines despite a low risk of metachronous neoplasia. However, the risk of metachronous advanced adenoma was increased in elderly patients and those with a ≥3-year surveillance interval.

Citations

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Risk of developing metachronous colorectal neoplasia after the resection of proximal versus distal adenomas
Yoon Suk Jung, Nam Hee Kim, Youngwoo Kim, Dong Il Park
Digestive and Liver Disease.2022; 54(4): 537. CrossRef
Post-polypectomy surveillance interval and advanced neoplasia detection rates: a multicenter, retrospective cohort study
Amanda J. Cross, Emma C. Robbins, Kevin Pack, Iain Stenson, Matthew D. Rutter, Andrew M. Veitch, Brian P. Saunders, Stephen W. Duffy, Kate Wooldrage
Endoscopy.2022; 54(10): 948. CrossRef
Comparison of Risk of Metachronous Advanced Colorectal Neoplasia in Patients with Sporadic Adenomas Aged < 50 Versus ≥ 50 years: A Systematic Review and Meta-Analysis
Yoon Suk Jung, Jung Ho Park, Chan Hyuk Park
Journal of Personalized Medicine.2021; 11(2): 120. CrossRef
British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland/Public Health England post-polypectomy and post-colorectal cancer resection surveillance guidelines
Matthew D Rutter, James East, Colin J Rees, Neil Cripps, James Docherty, Sunil Dolwani, Philip V Kaye, Kevin J Monahan, Marco R Novelli, Andrew Plumb, Brian P Saunders, Siwan Thomas-Gibson, Damian J M Tolan, Sophie Whyte, Stewart Bonnington, Alison Scope,
Gut.2020; 69(2): 201. CrossRef
Urine-NMR metabolomics for screening of advanced colorectal adenoma and early stage colorectal cancer
Eun Ran Kim, Hyuk Nam Kwon, Hoonsik Nam, Jae J. Kim, Sunghyouk Park, Young-Ho Kim
Scientific Reports.2019;[Epub] CrossRef
A Comparison of the Cumulative Incidences of Metachronous Colorectal Adenoma and Cancer According to the Initial FindingsAmong Colonoscopically Followed-up Patients
Seiji Kimura, Masanori Tanaka, Shinsaku Fukuda
Nippon Daicho Komonbyo Gakkai Zasshi.2019; 72(6): 395. CrossRef
Impact of obesity and metabolic abnormalities on the risk of metachronous colorectal neoplasia after polypectomy in men
Nam Hee Kim, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
Journal of Gastroenterology and Hepatology.2019; 34(9): 1504. CrossRef
Risk of developing metachronous advanced colorectal neoplasia after colonoscopic polypectomy in patients aged 30 to 39 and 40 to 49 years
Nam Hee Kim, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
Gastrointestinal Endoscopy.2018; 88(4): 715. CrossRef
Quality is the Key for Emerging Issues of Population-Based Colonoscopy Screening
Jin Young Yoon, Jae Myung Cha, Yoon Tae Jeen
Clinical Endoscopy.2018; 51(1): 50. CrossRef
Histologic discrepancy between endoscopic forceps biopsy and endoscopic mucosal resection specimens of colorectal polyp in actual clinical practice
Moon Joo Hwang, Kyeong Ok Kim, A Lim Kim, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
Intestinal Research.2018; 16(3): 475. CrossRef
Quality is the key for emerging issues of population-based colonoscopy screening
Jin Young Yoon, Jae Myung Cha, Yoon Tae Jeen
Intestinal Research.2018; 16(1): 48. CrossRef

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Case Reports

Cerebral venous thrombosis in a patient with Crohn's disease: Young-Hak Cho, Min Kyu Chae, Jae Myung Cha, Joung Il Lee, Kwang Ro Joo, Hyun Phil Shin, Il Hyun Baek, Jung Won Jeon, Jun Uk Lim, In Taik Hong, Hye-Jin Ki, Jae Bin Kang; Intest Res 2016;14(1):96-101. Published online January 26, 2016; DOI: https://doi.org/10.5217/ir.2016.14.1.96

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Patients with inflammatory bowel disease (IBD) have an elevated risk of venous thromboembolism compared with the general population. The most common sites of venous thromboembolism in IBD patients are the deep veins of the legs, the pulmonary system, and portal and mesenteric veins. However, cerebral venous thrombosis is rarely associated with IBD. This report describes a case of cerebral venous thrombosis in a patient with Crohn's disease. A 17-year-old girl, diagnosed 4 years earlier with Crohn's disease, presented with headache and vomiting. Magnetic resonance imaging of the brain with venography showed venous thrombosis in the cortical veins, superior sagittal sinus, right transverse sinus, and right internal jugular vein. The patient immediately started anticoagulation therapy with intravenous heparin infusion followed by daily oral rivaroxaban 10 mg. Follow-up imaging after 2 weeks showed resolution of the thrombosis, with recanalization of the cortical veins, superior sagittal sinus, right transverse sinus, and right internal jugular vein. She continued rivaroxaban therapy for 6 months, and remained well, without neurologic sequelae. A high level of concern for cerebral venous thrombosis may be important when treating active IBD patients, because anticoagulation treatment can prevent fatal complications.

Citations

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Cerebral venous thrombosis during relapse of ulcerative colitis: Case report with review of literature
S. Bouchal, B. Alami, N. Chtaou, M. Abkari, M. Maaroufi, F. Belahsen
JMV-Journal de Médecine Vasculaire.2021; 46(1): 22. CrossRef
Direct oral anticoagulants in treatment of cerebral venous thrombosis: a systematic review
Gauruv Bose, Justin Graveline, Vignan Yogendrakumar, Risa Shorr, Dean A Fergusson, Gregoire Le Gal, Jonathan Coutinho, Marcelo Mendonça, Miguel Viana-Baptista, Simon Nagel, Dar Dowlatshahi
BMJ Open.2021; 11(2): e040212. CrossRef
The Twists and Turns of Diagnosis and Treatment of Pediatric Neuro-Behcet's Disease: A Case Report and Literature Review
Qiao Zhang, Yizhen Luo, Jianli Zhou, Shaoming Zhou, Zhaoxia Wang
Frontiers in Pediatrics.2021;[Epub] CrossRef
Recurrent Unprovoked Venous Thrombosis (Cerebral Sinus Thrombosis and Mesenteric Vein Thrombosis) in Young Patient with Crohn’s Disease: A Case Report and Review
Abdullah Mohammed Albishi, Rafaat Chakik, Ali Saleh Alshamrani
Case Reports in Gastrointestinal Medicine.2020; 2020: 1. CrossRef
Use of direct oral anticoagulants in cerebral venous thrombosis: a systematic review
Sen Sheng, Krishina Nalleballe, Naga V. Pothineni, Rohan Sharma, Aliza Brown, Hisham Elkhider, Saritha Ranabothu, Nidhi Kapoor, Kelly-Ann Patrice, Sanjeeva Onteddu
Blood Coagulation & Fibrinolysis.2020; 31(8): 501. CrossRef
Direct oral anticoagulant use in patients with thrombophilia, antiphospholipid syndrome or venous thrombosis of unusual sites: A narrative review
Laurent Bertoletti, Ygal Benhamou, Yannick Béjot, Sylvestre Marechaux, Saida Cheggour, Boris Aleil, Nicolas Lellouche, Jean-Guillaume Dillinger, Aurélien Delluc
Blood Reviews.2018; 32(4): 272. CrossRef
A case of ulcerative colitis presenting with cerebral venous thrombosis
Junghwan Lee, Sung Wook Hwang, Jinhee Lee, Kyung Hwa Jung, Ha Il Kim, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang
Intestinal Research.2018; 16(2): 306. CrossRef
Rivaroxaban and Apixaban for Initial Treatment of Acute Venous Thromboembolism of Atypical Location
Dawid T. Janczak, Malgorzata K. Mimier, Robert D. McBane, Patrick S. Kamath, Benjamin S. Simmons, Dalene M. Bott-Kitslaar, Charles J. Lenz, Emily R. Vargas, David O. Hodge, Waldemar E. Wysokinski
Mayo Clinic Proceedings.2018; 93(1): 40. CrossRef
Use of Novel Oral Anticoagulant to Treat Pulmonary Thromboembolism in Patient with Ulcerative Colitis Superinfected Cytomegalovirus Colitis
Seok-Hwan Kim, Sunhee Jang, Yegyu Sung, Jun Kyu Park, Yunjung Park, Jintak Yun, Sang-Bum Kang
The Korean Journal of Gastroenterology.2017; 70(1): 44. CrossRef

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Anaphylactic Shock Caused by Ingestion of Polyethylene Glycol: Sun Hee Lee, Jae Myung Cha, Joung Il Lee, Kwang Ro Joo, Hyun Phil Shin, Il Hyun Baek, Jung Won Jeon, Jun Uk Lim, Jung Lok Lee, Hyae Min Lee, Young-Hak Cho; Intest Res 2015;13(1):90-94. Published online January 29, 2015; DOI: https://doi.org/10.5217/ir.2015.13.1.90

Abstract PDF PubReader

Colonoscopy is the current standard method for evaluation of the colon. The diagnostic accuracy and therapeutic safety of colonoscopy depend on the quality of colonic cleansing and preparation. Generally, all these preparations have been demonstrated to be safe for use in healthy individuals without significant comorbid conditions. Based on safety and efficacy concerns, polyethylene glycol (PEG) is most commonly utilized as a bowel preparation solution for colonoscopy. Adverse events in patients receiving PEG are mostly clinically non-significant. However, fatal adverse events rarely have been shown to occur in the few individuals who experience vomiting or aspiration. Anaphylactic shock associated with ingestion of PEG electrolyte solution is an extremely rare fatal complication, and reported mainly in Western countries. Here, we report the first case of anaphylactic shock following the ingestion of PEG solution in Korea.

Citations

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Poly(Ethylene Glycols) to Facilitate Celloidin Removal for Immunohistochemical Studies on Archival Human Brain and Temporal Bone Sections
David Bächinger, Jennifer T. O’Malley, Morris Wolf, Stephane Bérnhard, M. Charles Liberman, Mark W. Tibbitt, Andreas H. Eckhard
Journal of Histochemistry & Cytochemistry.2024; 72(7): 419. CrossRef
Anaphylatoxin Complement 5a in Pfizer BNT162b2-Induced Immediate-Type Vaccine Hypersensitivity Reactions
Xin Rong Lim, Grace Yin Lai Chan, Justina Wei Lynn Tan, Carol Yee Leng Ng, Choon Guan Chua, Guat Bee Tan, Stephrene Seok Wei Chan, Kiat Hoe Ong, Ying Zhi Tan, Sarah Hui Zhen Tan, Claire Min Li Teo, Samuel Shang Ming Lee, Bernard Yu Hor Thong, Bernard Pui
Vaccines.2023; 11(6): 1020. CrossRef
Anaphylactic shock induced by polyethylene glycol after bowel preparation for the colorectal cancer surgery: A case report
Go Woon Park, Nahyeon Park, Jung Cheol Kuk, Eung Jin Shin, Dae Ro Lim
World Journal of Clinical Cases.2023; 11(23): 5589. CrossRef
Neither iatrogenic nor hereditary cause: A rare case of anaphylaxis to low sorb tubing used for infusions
Amber Gibson, Muhammad Usman Baig, Sana Mohiuddin, Wafik Zaky
Pediatric Blood & Cancer.2021;[Epub] CrossRef
Anaphylaxis associated with the mRNA COVID-19 vaccines: Approach to allergy investigation
Viktorija Erdeljic Turk
Clinical Immunology.2021; 227: 108748. CrossRef
Coronavirus disease 2019 vaccines and relevant adverse reactions
Eun Hee Chung
Allergy, Asthma & Respiratory Disease.2021; 9(3): 124. CrossRef
Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies
Bing-Mae Chen, Tian-Lu Cheng, Steve R. Roffler
ACS Nano.2021; 15(9): 14022. CrossRef
Anaphylaxis due to macrogol in a laxative solution with a positive basophil activation test
Nicola Giangrande, Jesús Miguel García-Menaya, Mariana Marcos-Fernández, Carmen Cámara-Hijón, Pedro Bobadilla-González
Annals of Allergy, Asthma & Immunology.2019; 123(3): 302. CrossRef
Anaphylaxis due to polyethylene glycol: A case report
Tae-Se Kim, Dong-Chull Choi, Byung-Jae Lee
Allergy, Asthma & Respiratory Disease.2018; 6(5): 274. CrossRef
Hyponatremic Seizures After Polyethylene Glycol Bowel Preparation: The Elderly at Risk
Arjun Saradna, Shyam Shankar, Parita Soni, Chetana Pendkar, Abhinav Saxena, Yizhak Kupfer, Stephan Kamholz
American Journal of Therapeutics.2018; 25(6): e779. CrossRef
Anaphylaxis During Intracardiac and Endovascular Implantations: A Multifactorial Problem Involving Kounis Syndrome
Nicholas G. Kounis, Ioanna Koniari, George Soufras, Grigorios Tsigkas, George Hahalis
Journal of Cardiothoracic and Vascular Anesthesia.2017; 31(3): 804. CrossRef
“Bowel prep hyponatremia“ – a state of acute water intoxication facilitated by low dietary solute intake: case report and literature review
Martin Windpessl, Christoph Schwarz, Manfred Wallner
BMC Nephrology.2017;[Epub] CrossRef
Immediate‐type hypersensitivity to polyethylene glycols: a review
E. Wenande, L. H. Garvey
Clinical & Experimental Allergy.2016; 46(7): 907. CrossRef
Anaphylaxis to Polyethylene Glycol (Colyte®) in a Patient with Diverticulitis
So-Hee Lee, Sun Hyuk Hwang, Jin Soo Park, Hae-Sim Park, Yoo Seob Shin
Journal of Korean Medical Science.2016; 31(10): 1662. CrossRef
Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer
Thomas J. Povsic, Monica G. Lawrence, A. Michael Lincoff, Roxana Mehran, Christopher P. Rusconi, Steven L. Zelenkofske, Zhen Huang, Jeffrey Sailstad, Paul W. Armstrong, P. Gabriel Steg, Christoph Bode, Richard C. Becker, John H. Alexander, N. Franklin Adk
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Polyethylene Glycol (PEG)-Induced Anaphylactic Reaction During Bowel Preparation
David Gachoka
ACG Case Reports Journal.2015; 2(1): 216. CrossRef

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Original Articles

Association of Gallbladder Polyp with the Risk of Colorectal Adenoma: Jung Won Jeun, Jae Myung Cha, Joung Il Lee, Kwang Ro Joo, Hyun Phil Shin, Jun Uk Lim; Intest Res 2014;12(1):48-52. Published online January 28, 2014; DOI: https://doi.org/10.5217/ir.2014.12.1.48

Abstract PDF PubReader

Background/Aims

Gallbladder polyps and colorectal adenomas share many common risk factors; however, their association has never been studied. The aim of this study was to investigate this association in asymptomatic healthy subjects.

Methods

Consecutive asymptomatic subjects who underwent both screening colonoscopy and abdominal ultrasonography at Kyung Hee University Hospital in Gang Dong between July 2010 and April 2011 were prospectively enrolled. The prevalence of colorectal adenoma was compared between subjects with or without gallbladder polyps. Furthermore, a logistic regression analysis was performed to determine the independent risk factors for colorectal adenoma in these subjects.

Results

Of the 581 participants, 55 presented with gallbladder polyps and 526 did not have gallbladder polyps. Participants with gallbladder polyps showed a trend toward a higher prevalence of colorectal adenoma than those without gallbladder polyps (52.7% vs. 39.2%, P=0.051). Although the result was not statistically significant, gallbladder polyps were found to be a possible risk factor for colorectal adenoma (odds ratio=1.796, 95% confidence interval=0.986-3.269, P=0.055), even after adjusting for potential confounding factors. There was no difference observed in colorectal adenoma characteristics between the two groups.

Conclusions

Our results suggest a possible association between gallbladder polyps and colorectal adenomas. Future studies with larger cohorts are warranted to further investigate this matter.

Citations

Citations to this article as recorded by

Risk Factors for Colorectal Polyps
嫣琦王
Advances in Clinical Medicine.2023; 13(09): 14803. CrossRef
Research Progress of Factors Related to CRP in Middle-Aged and Elderly People
瑞武邢
Advances in Clinical Medicine.2022; 12(11): 10466. CrossRef
Association of gallbladder diseases with risk of gastrointestinal polyps
Wenbin Geng, Xiangrong Qin, Peng Yang, Junmei Wang, Jing Yu, Xiaoyong Wang
BMC Gastroenterology.2022;[Epub] CrossRef
Gallbladder Polyps Are Associated with Proximal Colon Polyps
Kuan-Chieh Lee, Wen-Juei Jeng, Chen-Ming Hsu, Chia-Jung Kuo, Ming-Yao Su, Cheng-Tang Chiu
Gastroenterology Research and Practice.2019; 2019: 1. CrossRef
Gallbladder Adenoumatous Polyps prevelance in Cholcystectomy in Saudi Arabia-cross sectional study
Alharbi Mohammad
Journal of Surgery and Surgical Research.2019; 5(1): 047. CrossRef
Gallbladder stones and gallbladder polyps associated with increased risk of colorectal adenoma in men
Yen‐Ling Liu, Jin‐Shang Wu, Yi‐Ching Yang, Feng‐Hwa Lu, Chih‐Ting Lee, Wan‐Ju Lin, Chih‐Jen Chang
Journal of Gastroenterology and Hepatology.2018; 33(4): 800. CrossRef
Risk of Colorectal Neoplasia According to Fatty Liver Severity and Presence of Gall Bladder Polyps
Taeyoung Lee, Kyung Eun Yun, Yoosoo Chang, Seungho Ryu, Dong Il Park, Kyuyong Choi, Yoon Suk Jung
Digestive Diseases and Sciences.2016; 61(1): 317. CrossRef
Can gallbladder polyps predict colorectal adenoma or even neoplasia? A systematic review
Konstantinos Stergios, Christos Damaskos, Maximos Frountzas, Nikolaos Nikiteas, Olutunde Lalude
International Journal of Surgery.2016; 33: 23. CrossRef
The Risk of Colorectal Neoplasia in Patients with Gallbladder Diseases
Sung Noh Hong, Tae Yoon Lee, Sung-Cheol Yun
Journal of Korean Medical Science.2015; 30(9): 1288. CrossRef
Recent Updates on the Diagnosis and Management of Gallbladder Polyps
Eaum Seok Lee
Korean Journal of Pancreas and Biliary Tract.2014; 19(2): 64. CrossRef

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Preoperative Carbohydrate Antigen 19-9 Levels Can Predict Stage and Survival Rate in Patients with Colorectal Cancer: Soo Young Moon, Jae Myung Cha, Joung Il Lee, Kwang Ro Joo, Hyun Phil Shin, Jae Jun Park, Jung Won Jeon, Jun Uk Lim, Seung Jung Jun, Yoon Jong Seo, Chi Hoon Lee; Intest Res 2013;11(3):184-190. Published online July 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.3.184

Abstract PDF

Background/Aims
The purpose of this study was to determine whether preoperative carbohydrate antigen 19-9 (CA 19-9) levels can predict the stage of diseases or survival rate in patients with resectable colorectal cancer (CRC). Methods: A total of 247 patients who underwent curative resections at Kyung Hee University Hospital at Gangdong between 2006 and 2011 were enrolled. We investigated the correlations of preoperative serum levels of CA19-9 with clinicopathological features of CRC. Receiver operative curve was constructed for evaluating the efficiency of the serum CA 19-9 levels in the stratifying stage of CRC. Survival analysis was performed with Kaplan-Meire method and log-rank test. Cox regression analysis was used for the multivariate analysis for survival. Results: Abnormal level of serum CA 19-9 (>37 IU/mL) were associated with advanced T stage (P<0.001), N stage (P=0.002) and TNM stage (P<0.001) in patients with resectable CRC. Furthermore, abnormal level of serum CA 19-9 were related with vascular invasion (P=0.002) and lymphatic invasion (P=0.026). The area under the curve was 0.75 (95% confidence interval [CI] 0.67-0.83) for T4 stage CRC and 0.680 (95% CI 0.61-0.75) for TNM stage III CRC. In patients with TNM stage III CRC, a preoperative CA 19-9 higher than 60 IU/mL (P=0.033) and presence of vascular invasion (P=0.002) were identified as significant predictors of survival rate on multivariate analysis. Conclusions: In patients with resectable CRC, preoperative CA 19-9 correlates with T stage, N stage and TNM stage of disease. Serum CA 19-9 >60 U/mL was an independent predictor of survival rate in the patients with TNM stage III CRC. (Intest Res 2013;11:184-190)

Citations

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Neutrophil to lymphocyte ratio can predict overall survival in patients with stage II to III colorectal cancer
Yerim Cho, Su Bee Park, Jin Young Yoon, Min Seob Kwak, Jae Myung Cha
Medicine.2023; 102(11): e33279. CrossRef

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Clinical Characteristics and Outcomes of Diverticulitis by Physician's Specialty: Seung Jung Jun, Jae Myung Cha, Joung Il Lee, Kwang Ro Joo, Hyun Phil Shin, Jae Jun Park, Jung Won Jeon, Jun Uk Lim, Yoon Jong Seo, Soo Young Moon, Chi Hoon Lee; Intest Res 2013;11(2):92-99. Published online April 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.2.92

Abstract PDF: Background/Aims
Several factors affecting the severity and outcomes of diverticulitis have been reported, but there is little research on physician specialty related with this disease. Therefore, we evaluated the clinical characteristics and outcomes of diverticulitis depending on physician's specialty. Methods: Medical records of 239 patients, who had been hospitalized with first-diagnosed acute colonic diverticulitis at Kyung Hee University Hospital in Gang Dong (Seoul, Korea) from June 2006 to December 2012, were retrospectively analyzed. The patients were classified according to whether they had been managed by gastroenterologists or not. Clinical characteristics and treatment outcomes were compared between two groups. Results: Of these 239 patients, 38 (15.9%) patients were treated by a gastroenterologist and 201 (84.1%) patients by a non-gastroenterologist. Clinical characteristics such as age, gender, body mass index, comorbidity, medication, laboratory results, recurrence and complication were not significantly different between two groups. However, right-sided diverticulitis predominated in the non-gastroenterologist group (79% vs. 91%, P=0.028). From the sub-group analysis of uncomplicated diverticulitis, intravenous antibiotics was used for a shorter period of time by gastroenterologists than non-gastroenterologists (3.3±1.9 days vs. 4.4±2.8 days, P=0.032). Multivariate logistic regression analysis showed that the 3 day administration of intravenous antibiotics significantly depended on the physician's specialty (odds ratio 7.984, 95% confidence interval 1.990-32.043, P=0.003). Conclusions: The results suggest that the duration of intravenous antibiotics for treating uncomplicated colonic diverticulitis was shortened by gastroenterology specialists without increasing operation or recurrence. (Intest Res 2013;11:92-99)

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The Improvement of Nutritional Support with Percutaneous Endoscopic Gastrostomy: Yoon Jong Seo, Jae Myung Cha, Joung Il Lee, Kwang Ro Joo, Hyun Phil Shin, Jae Jun Park, Jung Won Jeon, Jun Uk Lim, Seung Jung Jun, Soo Young Moon, Soo Young Moon, Mi Ran Cho, Jung Sook Lee; Intest Res 2013;11(2):120-126. Published online April 30, 2013; DOI: https://doi.org/10.5217/ir.2013.11.2.120

Abstract PDF

Background/Aims
Percutaneous endoscopic gastrostomy (PEG) is the most common method of enteral nutrition for patients who require long term artificial nutrition. PEG has been used as a method of nutritional support; however, improvement of nutritional support via PEG has not yet been reported. In this study, we analyzed the efficacy of nutritional support via PEG. Methods: We conducted a retrospective analysis of 196 consecutive patients who underwent PEG at Kyung Hee University Hospital in Gang Dong from 2006 to 2012. We analyzed clinical characteristics, the method of nutritional support, and the proportion of intake to establish recommendations for nutritional requirements and the duration needed to reach the level of appropriate nutrition. Results: A total of 196 patients included 130 men and 66 women, and their mean age (standard deviation) was 69.1±14.0 years. Compared with caloric and protein supplementation before PEG, 113 kcal (13.8% of baseline) and 4.8 g of protein (17.5% of baseline) could be additionally supplied with PEG (P=0.001, respectively). The number of patients who could take more than 90% of the recommended requirements of caloric and protein supplementation after PEG showed increased caloric and protein intake by 25.4% and 20.2%, respectively, in comparison with those before PEG (P=0.001 and P=0.001, respectively). The mean duration of catch-up for more than 90% of the recommended caloric and protein intake was approximately 11 days. Procedure related complications and early mortality were reported in 8.1% and 0% of patients, respectively. Conclusions: PEG is an effective and safe nutritional support method for patients who require long term artificial nutrition. (Intest Res 2013;11:120-126)

Citations

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Reappraisal of Pneumoperitoneum After Percutaneous Endoscopic Gastrostomy
Won Young Park, Tae Hee Lee, Joon Seong Lee, Su Jin Hong, Seong Ran Jeon, Hyun Gun Kim, Joo Young Cho, Jin Oh Kim, Jun Hyung Cho, Sang Wook Lee, Young Kwan Cho
Intestinal Research.2015; 13(4): 313. CrossRef

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Clinicopathological Characteristics of Colorectal Cancer according to Gender Difference: Dae Ho Kim, Jae Myung Cha, Joung Il Lee, Kwang Ro Joo, Hyun Phil Shin, Jae Jun Park, Jung Won Jeon, Jun Uk Lim, Seung Jung Jun, Yoon Jong Seo; Intest Res 2012;10(4):365-371. Published online October 31, 2012; DOI: https://doi.org/10.5217/ir.2012.10.4.365

Abstract PDF

Background/Aims
Colorectal cancer (CRC) has been one of the major causes of death and has become a major public health concern. The incidence of CRC has been increasing regardless of gender in Korea. Until now, however, the studies on gender-based clinicopathological characteristics of CRC focused on pathology have never been reported. Therefore, we aimed to evaluate the difference in clinicopathological characteristics of CRC according to gender in Korea. Methods: Medical records of 342 patients with advanced CRC who underwent surgical resection at Kyung Hee University Hospital at Gangdong from June 2006 to December 2011 were retrospectively analyzed. The data of the clinicopathological characteristics of CRC by gender difference were compared. Results: Of these 341 patients, 203 (60%) patients were male and 138 (40%) patients were female. The male preponderance was noted in all age groups for total CRC and left-sided CRC. However, for right-sided colon cancer, this male preponderance was significantly decreased with increasing age groups (P=0.025) and was finally reversed in elderly groups (age ≥60 years). The microsatellite instability represented by negative staining for hMLH1 and hMSH2 was more frequently detected in women than men (P=0.037). Conclusions: The male preponderance in right-sided colon cancer decreased with increasing age groups and finally reversed in age groups more than 60 years. Microsatellite instability with immunohistochemical staining was more frequently detected in women. However, further studies with a large number of patients are warranted on this issue. (Intest Res 2012;10:365-371)

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Screening strategy for colorectal cancer according to risk
Dong Soo Han
Journal of the Korean Medical Association.2017; 60(11): 893. CrossRef
Prevalence, Clinicopathologic Characteristics, and Predictors of Interval Colorectal Cancers in Korean Population
Chang Joon Kim, Yoon Suk Jung, Jung Ho Park, Hong Joo Kim, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Shin Yeong Lee, Hwa Mok Kim, Ki Bae Bang, Dae Sung Lee, Dong Il Park
Intestinal Research.2013; 11(3): 178. CrossRef

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Case Report

Mucosa-Associated Lymphoid Tissue Lymphoma of the Rectum Cured by Radiotherapy: Joon Gi Min, Jae Ho Choi, Eun Young Kim, Hyun Soo Kim, Jae Myung Cha, Joung Il Lee, Kwang Ro Joo, Hyun Phil Shin, Jae Jun Park, Weon Kyu Chung; Intest Res 2012;10(2):201-205. Published online April 30, 2012; DOI: https://doi.org/10.5217/ir.2012.10.2.201

Abstract PDF

Primary rectal mucosa-associated lymphoid tissue (MALT) lymphoma is a particularly rare disease, comprising ＜1% of gastrointestinal lymphomas. Although antibiotic therapy has been demonstrated effective for gastric MALT lymphoma, the optimal treatment for MALT lymphoma of the rectum is unknown. Radiotherapy or surgery is often used to treat limited stage MALT lymphoma of the rectum. Here, we describe a case of a 44-year-old-man, who was diagnosed with primary MALT lymphoma of the rectum through colonoscopy. Other staging evaluations, including upper gastrointestinal endoscopy, abdomino-pelvic CT, chest CT, 18F fludeoxyglucose-positron emission tomography, and a bone marrow examination showed no other abnormalities, except stage IA para-rectal lymphadenopathy. The patient received 2 months of radiotherapy without major toxicity. A follow-up abdomino-pelvic CT scan revealed marked improvement in the volume of rectal lymphoma and adjacent lymph nodes. Mucosal nodularity of the lower rectum had completely regressed at the follow-up endoscopy and complete remission was confirmed with a biopsy. (Intest Res 2012;10: 0-205)

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Endoscopic features and clinical outcomes of colorectal mucosa-associated lymphoid tissue lymphoma
Min Kyung Jeon, Hoonsub So, Jooryung Huh, Hee Sang Hwang, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Kee Don Choi, Byong Duk Ye, Seung-Jae Myung, Suk-Kyun Yang, Jeong-Sik Byeon
Gastrointestinal Endoscopy.2018; 87(2): 529. CrossRef

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Original Article

The Significance of Fecal Immunochemical Test to Screen for Colorectal Cancer in National Cancer Screening Program: Jun Uk Lim, Na Young Bae, Won Koung Song, Jae Myung Cha, Joung Il Lee; Intest Res 2010;8(2):126-134. Published online December 30, 2010; DOI: https://doi.org/10.5217/ir.2010.8.2.126

Abstract PDF

Background/Aims
Colorectal cancer (CRC) is one of the major causes of death and poses a major public health concern. The National CRC Screening Programme (NCSP) provides annual CRC screening using a fecal occult blood test for individuals ＞50 years of age since 2004. The purpose of the current study was to determine the outcomes and efficacy of a fecal immunochemical test (FIT) based on the NCSP in a quality-controlled university hospital setting. Methods: We retrospectively reviewed the medical records and a standardized questionnaire from the NCSP of 3,852 individuals who underwent a FIT between March and December 2009. All of the subjects submitted a stool specimen for a FIT, while a double-contrast barium enema or colonoscopy was performed as a confirmatory examination for FIT-positive individuals. The CRC screening rate and rate of detection colorectal adenomas, advanced adenomas, and colorectal cancers by FIT were evaluated. Results: The CRC screening rate with FIT was very high (72.3%), but the positive rate of detection by FIT was only 1.3%. The rate of detection for colorectal cancers, adenomas, and advanced adenomas by FIT was 0.08%, 0.39%, and 0.13%, respectively. The quantitative values of FIT in individuals with colorectal adenomas and cancers were significantly higher than other colorectal diseases. Men (P=0.001) and elderly individuals (P=0.039) were significantly more common in the FIT-positive group than the FIT-negative group. Approximately 28% of the subjects with FIT-positive tests did not receive a confirmatory examination. Conclusions: Although the FIT had a low rate of detection, the FIT was a useful screening tool for detection of CRC in the NCSP. It will be important to increase CRC screening rates and confirmatory examination rates. (Intest Res 2010;8:126-134)

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Factors influencing colonoscopy behaviour among Koreans with a positive faecal occult blood tests
EunHee Choi, JaeHee Jeon, JinHee Kim
European Journal of Cancer Care.2019; 28(2): e13008. CrossRef
Performance Evaluation of Two Automated Quantitative Fecal Occult Blood Tests
Ari Ahn, Jeongeun Kim, Young Jin Ko, Heungsup Sung, Mi-Na Kim
Laboratory Medicine Online.2016; 6(4): 233. CrossRef
A comparison of qualitative and quantitative fecal immunochemical tests in the Korean national colorectal cancer screening program
Mi Jin Park, Kui Son Choi, You Kyoung Lee, Jae Kwan Jun, Hoo-Yeon Lee
Scandinavian Journal of Gastroenterology.2012; 47(4): 461. CrossRef
Telephone Reminder Call in Addition to Mailing Notification Improved the Acceptance Rate of Colonoscopy in Patients with a Positive Fecal Immunochemical Test
Jae Myung Cha, Joung Il Lee, Kwang Ro Joo, Hyun Phil Shin, Jae Jun Park
Digestive Diseases and Sciences.2011; 56(11): 3137. CrossRef
The Significance of Fecal Immunochemical Test in National Cancer Screening Program
Dong Il Park
Intestinal Research.2010; 8(2): 200. CrossRef

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Case Report

Recurrent Primary Signet Ring Cell Cancer of the Colon at Anastomosis Site after Curative Resection: Yu Jin Suh, Jae Myung Cha, Joung Il Lee, Kwang Ro Joo, Sung Won Jung, Hyun Phil Shin, Soo Woong Kim; Intest Res 2010;8(1):58-62. Published online June 30, 2010; DOI: https://doi.org/10.5217/ir.2010.8.1.58

Abstract PDF: A primary signet ring cell cancer (SRCC) is a rare form of an adenocarcinoma of the large intestine. The prognosis of SRCC of the colon has been reported to be worse than classic adenocarcinoma of the colon; however, there is no difference in the post-operative surveillance for SRCC. We report a case of SRCC of the colon with negative resection margins that recurred at the anastomosis site 26 months after curative resection. A 55-year-old male presented to the hospital with abdominal pain. The initial colonoscopy and abdominal computed tomography revealed SRCC of the proximal ascending colon. He underwent extensive curative surgical resection and adjuvant chemotherapy for 8 months. However, 26 months post-operatively, the cancer recurred at the anastomosis site without peritoneal dissemination. Physicians should be aware that SRCC may have different recurrence patterns compared with classic adenocarcinoma, and may need more vigorous surveillance, even after curative surgery. (Intest Res 2010;8:58-62)

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Original Articles

A Roles of Apoptotic Genes in Colon Cancers: Jae Young Jang, Hyo Jong Kim, Sung-Gil Chi, Kil Yeon Lee, Ki Deuk Nam, Nam Hoon Kim, Sang Kil Lee, Kwang Ro Joo, Seok Ho Dong, Byung-Ho Kim, Young Woon Chang, Joung Il Lee, Rin Chang; Intest Res 2004;2(2):71-76. Published online December 22, 2004

Abstract PDF: Badkground/Aims: X-linked inhibitor of apoptosis (XIAP) is the most potent member of the IAP family that exerts antiapoptotic effects. Recently, XIAP-associated factor 1 (XAF1) and two mitochondrial proteins, Smac/DIABLO and HtrA2, have been identified to negatively regulate the caspase-inhibiting activity of XIAP. We explored the candidacy of XAF1, Smac/DIABLO and HtrA2 as a tumor suppressor in colonic carcinogenesis. Methods: The expression and mutation status of the genes were assessed in 10 colorectal carcinoma cell lines. Results: XAF1 transcript was not expressed or present at extremely low levels in 60% (6/10) of cancer cell lines whereas Smac/DIABLO and HtrA2 are normally expressed in all cell lines examined. XAF1 transcript was reactivated in all low expressor cell lines by treatment with the demethylating agent 5-aza-2'-deoxycytidine. Moreover, bisulfite DNA sequencing analysis for 34 CpG sites in the promoter region revealed a strong association between hypermethylation and gene silencing. Restoration of XAF1 expression resulted in enhanced apoptotic response to etoposide and 5-flurouracil. Conclusions: XAF1 undergoes epigenetic gene silencing in a considerable proportion of human colon cancers by aberrant promoter hypermethylation, suggesting that XAF1 inactivation might be implicated in colonic tumorigenesis. (Intestinal Research 2004;2:71-76)

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Bioflor^Ⱂ Suppresses Expression of Interleukin-8 in HT-29 cell: Sang Kil Lee, Hyo Jong Kim, Sung Gil Chi, Jae Young Jang, Ki Deok Nam, Nam Hoon Kim, Kwang Ro Joo, Seok Ho Dong, Byung Ho Kim, Young Woon Chang, Joung Il Lee, Rin Chang; Intest Res 2004;2(2):96-101. Published online December 22, 2004

Abstract PDF: Background/Aims
Nowadays, there is a growing interest in probiotics as a safe way of changing the intestinal bacterial flora. Probiotics may have potential in several gastroenterological conditions. The nonpathogenic yeast, Saccharomyces boulardii (S. boulardii, Bioflor^Ⱂ), has been used empirically in the treatment of acute infectious diarrhea and antibiotics-associated diarrhea. Recently, S. boulardii was reported to be beneficial in the treatment of inflammatory bowel disease, however, little is known about their mechanisms of action. We examined the ability of S. boulardii to modulate inflammatory response in human colon cells. Methods: Effects of Bioflor^Ⱂ on survival and proliferation of HT-29 human colon cells were assessed by MTT and [3H]thymidine incorporation assays. Interleukin-8 (IL-8) expression was stimulated with tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), or lipopolysacharide (LPS). IL-8 was assessed by RT-PCR. Results: Bioflor^Ⱂ did not affect viability and proliferation of HT-29 cell. Pretreatment of HT-29 cells with Bioflor^Ⱂ blocked IL-8 up-regulation by TNF-α, IL-1β, or LPS to these proinflammatory factors. Conclusions: Bioflor^Ⱂ reduces responses to proinflammatory cytokines in human colon cells. (Intestinal Research 2004;2:96-101)

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Case Reports

A Case of Anikiasis Invading the Ascending Colon: Doo Hyun Woo, Hyo Jong Kim, Han Soo Kim, Jae Young Chang, Ki Duk Nam, Nam Hoon Kim, Sang Kil Lee, Kwang Roh Joo, Seok Ho Dong, Byung Ho Kim, Young Woon Chang, Joung Il Lee, Rin Chang; Intest Res 2004;2(2):120-123. Published online December 22, 2004

Abstract PDF: Anisakiasis is a human disease caused by the accidental ingestion of larval nematodes, belonging to the family Anisakidae. The disease is caused by eating raw seafood dishes or undercooked fish and squid dishes. Considering the popularity of eating the raw fish in Korea, the incidence of anisakiasis has been increasing. The entire gastrointestinal tract from the esophagus to the rectum can be involved. Colonic anisakiasis is very rare, and it is relatively hard to diagnose compared with gastric anisakiasis. We are reporting a case of anisakiasis involving the ascending colon, which was treated by colonoscopic removal. (Intestinal Research 2004;2:120-123)

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Two Cases of Desmoid Tumor After the Total Colectomy in FAP Patients: Bo Young Hwang, Hyo Jong Kim, Jae Young Chang, Nam Hoon Kim, Sang Kil Lee, Kwnag Ro Joo, Seok Ho Dong, Joung Il Lee, Byung Ho Kim, Young Woon Chang, Rin Chang; Intest Res 2004;2(1):31-35. Published online April 16, 2004

Abstract PDF: Desmoid tumors (DT) are rare and slow-growing tumor that consist of proliferation of well-differentiated fibroblast. Although the typical characteristics of malignant tumors, such as distant metastasis, are absent, the tumor are locally aggressive and grow into neighbouring structures and have a high propensity for recurrence after surgical resection. Surgical trauma, genetic predisposition and hormonal factors are considered to be correlated with the development and growth of DT. The prevalence of desmoid tumors in patients with familial adenomatous polyposis (FAP) is 7-12%. The lifetime risk of developing desmoid tumors is about 20%. Inpatients with FAP, desmoids often appear after total colectomy as descrete masses in surgical scars of the abdominal wall or as infiltrating fibroblast sheets within the abdominal mesentery or retroperitoneum. Intra-abdominal or mesenteric desmoids pose a serious management problem because of their propensity to surroud and compress major blood vessels and viscera. Next to colorectal cancer, desmoid tumors are the most frequent cause of death in FAP. There are no standard medical approaches. Recently we experienced two cases of desmoid tumor associated with FAP after total colectomy. One case treated with non steroidal anti-inflammatory drug (NSAID) and tamoxifen, the other with combination chemotherpy. We report comparision of two cases with review of the literatures. (Intestinal Research 2004;2:31-35)

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A Case of Small Bowel Bleeding not Being Found by Capsule Endoscopy: Myung Ryul Lee, Hyo Jong Kim, Sang Kil Lee, Nam Hoon Kim, Jae Young Chang, Kwang Ro Joo, Seok Ho Dong, Byung-Ho Kim, Young Woon Chang, Joung Il Lee, Rin Chang; Intest Res 2004;2(1):40-42. Published online April 16, 2004

Abstract PDF: Diagnostic tool for the study of patients with obscure gastrointestinal bleeding is not confirmed. Recently,capsule endoscopy was used to the effective diagnostic tool for patients with obscure gastrointestinaI bleeding, and was well tolerated and better accepted by patient. But the diagnostic result of this technique has not been adequately studied. We reported a case of finding small bowel beeding due to intraoperative endoscopy with negative capsule endoscopic result. (Intestinal Research 2004;2:40-42)

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Genetic Analysis in a Case of Turcot's Syndrome Associated with Cerebral Oligodendroglioma: Han Soo Kim, Ji Young Park, Hyo Jong Kim, Sung-Gil Chi, Yoon Hwa Kim, Kil Yeon Lee, Yong Hee Joung, Yo Seb Han, Seok Ho Dong, Byung Ho Kim, Young Woon Chang, Joung Il Lee, Rin Chang; Intest Res 2003;1(2):192-196. Published online November 27, 2003

Abstract PDF: Turcot's syndrome (TS) is a genetic disease characterized by primary brain tumor, colon cancer and/or multiple colorectal polyps. The mode of genetic transmission of the syndrome still remains unclear because TS is a rare disorder. The majority of central nervous system (CNS) neoplasms associated with TS are glioma, glioblstoma multiformes and medulloblastoma. Other types of CNS tumors related to TS have been noted in a few case reports, and there are only two reports of oligodendroglioma associated with TS. To the authors' knowledge, this is the first case of a patient with TS who had a cerebral oligodendroglioma and a colorectal adenocarcinoma in Korea. Therefore, the authors performed genetic analysis of this patient and her family to determine the genetic variants, including mutations in APC gene and mismatch repair gene, in Turcot's syndrome. (Intestinal Research 2003;2:192-196)

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Original Articles

Genetic Anticipation in Korean Patients with Inflammatory Bowel Disease: Byoung Wook Lee, Hyo Jong Kim, Suk-Kyun Yang, Jong Beom Park, Yong Hee Jeong, Yo Seb Han, Won Gab Park , Seok Ho Dong , Byung Ho Kim, Young Woon Chang, Joung Il Lee, Rin Chang, Young Il Min; Intest Res 2003;1(1):31-38. Published online May 27, 2003

Abstract PDF: Background/Aims
Several recent epidemiologic studies in familial inflammatory bowel disease (IBD) reported preliminary evidences for genetic anticipation in IBD. However, presence of genetic anticipation in IBD has been questioned. We studied pairs of two-generation first-degree relatives with IBD to identify evidence for genetic anticipation in Korean patients with familial IBD and to know the influence of gender of transmitting parent on anticipation in IBD. Methods: Through retrospective review of the records of 11 parent-child pairs with IBD, we compared age at diagnosis (AAD) and severity of disease between generations and investigate difference in the degree of anticipation with respect to gender of transmitting parent. Results: At the time of study enrollment, the mean age of parents was 56.2 years and 29.1 years in children. Diagnostic intervals (time from first symptoms to diagnosis) between generations were similar (p=0.307). The mean AAD was 21.7 years younger in children than in parents (p<0.001). But, the degree of anticipation was not different according to gender of transmitting parents (p=0.369). Also, severities of disease were not significantly different between generations. Conclusions: Genetic anticipation may exist in Korean patients with familial IBD but, further studies with larger cohorts and sufficient observation time is warranted to rule out the effect of short follow-up time bias. (Intestinal Research 2003;1:31-38)

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Comparison of Postoperative Ouality of Life in Ulcerative Colitis According to the Operative Method: Ileostomy versus Ileoanal Pouch Anastomosis: Yong Hee Joung , Hyo Jong Kim, Kil Yeon Lee, Byoung Wook Lee, Yo Seb Han, Seok Ho Dong, Byung Ho Kim, Young Woon Chang, Joung Il Lee, Rin Chang; Intest Res 2003;1(1):39-44. Published online May 27, 2003

Abstract PDF: Background/Aims
Ileostomy (IL) and ileal-pouch anal anastomosis (IPAA) are treatment of choice in ulcerative colitis. We investigate the complications and quality of life after operation according to the operative methods. Methods: We analyzed patients experienced total proctocolectomy. We divided them in two groups according to the operation methods. We analyzed the characteristics and outcomes after IL or IPAA group for evaluation quality of life and evaluated the characteristics of patients preoperative and postoperative state retrospectively. Results: Fourteen patients were enrolled this study. IPAA was done at eight of them and IL was done at the six of them. There were no difference in sex, age, frequency of use of immunosuppressive agent, duration of medication of steroid and duration of ulcerative colitis according to the operation methods. Most common indication of operation was medical intractability. Similar incidence of postoperative complication in both operation methods. According to the questionnares for evaluating of quality of life, we compared both operation method. There was no difference. But in IPAA, antidiarrheal medication was more needed. Conclusions: In IL and IPAA, quality of life was improved. There was no difference in quality of life in IL and IPAA. (Intestinal Research 2003;1:39-44)

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