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Inflammatory bowel diseases
Fibrostenotic strictures in Crohn’s disease
Jun Hwan Yoo, Stefan Holubar, Florian Rieder
Intest Res 2020;18(4):379-401.   Published online April 10, 2020
DOI: https://doi.org/10.5217/ir.2019.09148
AbstractAbstract PDFPubReaderePub
The use of biologic agents including anti-tumor necrosis factor monoclonal antibodies followed by anti-integrins and anti-interleukins has drastically changed the treatment paradigm of Crohn’s disease (CD) by improving clinical symptoms and mucosal healing. However, up to 70% of CD patients still eventually undergo surgery mainly due to fibrostenotic strictures. There are no specific anti-fibrotic drugs yet. This review comprehensively addresses the mechanism, prediction, diagnosis and treatment of the fibrostenotic strictures in CD. We also introduce promising anti-fibrotic agents which may be available in the near future and summarize challenges in developing novel therapies to treat fibrostenotic strictures in CD.

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