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Rapid and accurate diagnosis of
Clostridium difficile infection by real-time polymerase chain reaction - Pil Hun Song, Jung Hwa Min, You Sun Kim, Soo Yeon Jo, Eun Jin Kim, Kyung Jin Lee, Jeonghun Lee, Hyun Sung, Jeong Seop Moon, Dong Hee Whang
- Intest Res 2018;16(1):109-115. Published online January 18, 2018
- DOI: https://doi.org/10.5217/ir.2018.16.1.109
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Abstract
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ePub <b>Background/Aims</b><br/> The incidence and severity of
Clostridium difficile infection (CDI) have increased worldwide, resulting in a need for rapid and accurate diagnostic methods.Methods A retrospective study was conducted to compare CDI diagnosis methods between January 2014 and December 2014. The stool samples, which were obtained in presumptive CDI patients, were compared for their diagnostic accuracy and rapidity, including real-time polymerase chain reaction (PCR) of toxin genes,
C. difficile toxin assay, and culture forC. difficile .Results A total of 207 cases from 116 patients were enrolled in this study and 117 cases (56.5%) were diagnosed as having CDI. Among the 117 cases, the sensitivities of real-time PCR,
C. difficile toxin assay, and culture forC. difficile were 87.2% (102 cases; 95% CI, 80.7%–92.8%), 48.7% (57 cases; 95% CI, 41.0%–59.8%), and 65.0% (76 cases; 95% CI, 60.2%–78.5%), respectively (P <0.005). Notably, 34 cases (29.0%) were diagnosed with CDI by real-time PCR only. The time required to obtain results was 2.27 hours (136.62±82.51 minutes) for real-time PCR, 83.67 hours (5,020.66±3,816.38 minutes) for toxin assay, and 105.79 hours (6,347.68±3,331.46 minutes) for culture (P <0.005), respectively.Conclusions We confirmed that real-time PCR of toxin genes is the most effective diagnostic method for accurate and early diagnosis of CDI. It also helps to diagnose hypervirulent CDI, such as ribotype 027 infection.
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Citations
Citations to this article as recorded by
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Seo Hyun Kim, You Sun Kim, Seung Hyuk Kim, Won Eui Yoon, Hee Jun Myung, Jeong Seop Moon, Dong Hee Whang
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Ashley Howard, Michelle R. Rychalsky, Thomas S. Murray
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Jiyoun Song, Bevin Cohen, Philip Zachariah, Jianfang Liu, Elaine L. Larson
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Heera Jeong, Ji-Man Kang, Jong Gyun Ahn
Pediatric Infection & Vaccine.2020; 27(3): 158. CrossRef - RecurrentClostridium difficileInfection: Risk Factors, Treatment, and Prevention
Jung Hoon Song, You Sun Kim
Gut and Liver.2019; 13(1): 16. CrossRef - Is Clostridium difficile infection a real threat in patients with ulcerative colitis? A prospective, multicenter study in Korea
Dae Bum Kim, Kang-Moon Lee, Sang Hyoung Park, You Sun Kim, Eun Soo Kim, Jun Lee, Sung-Ae Jung, Geom Seog Seo, Ji Min Lee
Intestinal Research.2018; 16(2): 267. CrossRef
- Clostridium Difficile Infection in Childhood: Case Series
- 8,976 View
- 94 Download
- 7 Web of Science
- 8 Crossref
- Risk Factors for Delayed Post-Polypectomy Bleeding
- Min Jung Kwon, You Sun Kim, Song I Bae, Young Il Park, Kyung Jin Lee, Jung Hwa Min, Soo Yeon Jo, Mi Young Kim, Hye Jin Jung, Seong Yeon Jeong, Won Jae Yoon, Jin Nam Kim, Jeong Seop Moon
- Intest Res 2015;13(2):160-165. Published online April 27, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.2.160
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Abstract
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<b>Background/Aims</b><br/> Among the many complications that can occur following therapeutic endoscopy, bleeding is the most serious, which occurs in 1.0-6.1% of all colonoscopic polypectomies. The aim of this study was to identify risk factors of delayed post-polypectomy bleeding (PPB).
Methods We retrospectively reviewed the data of patients who underwent colonoscopic polypectomy between January 2003 and December 2012. We compared patients who experienced delayed PPB with those who did not. The control-to-patient ratio was 3:1. The clinical data analyzed included polyp size, number, location, and shape, patient' body mass index (BMI), preventive hemostasis, and endoscopist experience.
Results Of 1,745 patients undergoing colonoscopic polypectomy, 21 (1.2%) experienced significant delayed PPB. We selected 63 age- and sex-matched controls. Multivariate logistic regression analysis showed that polyps >10 mm (odds ratio [OR], 2.605; 95% confidence interval [CI], 1.035-4.528;
P =0.049), a pedunculated polyp (OR, 3.517; 95% CI, 1.428-7.176;P =0.045), a polyp located in the right hemicolon (OR, 3.10; 95% CI, 1.291-5.761;P =0.013), and a high BMI (OR, 3.681; 95% CI, 1.876-8.613;P =0.013) were significantly associated with delayed PPB.Conclusions Although delayed PPB is a rare event, more caution is needed during colonoscopic polypectomies performed in patients with high BMI or large polyps, pedunculated polyps, or polyps located in the right hemicolon.
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Citations
Citations to this article as recorded by- The Use of Clips to Prevent Post-Polypectomy Bleeding: A Clinical Review
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International Journal of Gastrointestinal Intervention.2024; 13(4): 122. CrossRef - Colonic polypectomy in 2024: hot or cold?
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Aaron Yeoh, Ajitha Mannalithara, Uri Ladabaum
Clinical Gastroenterology and Hepatology.2023; 21(2): 507. CrossRef - Prophylactic clipping to prevent delayed colonic post-polypectomy bleeding: meta-analysis of randomized and observational studies
Kirles Bishay, Zhao Wu Meng, Levi Frehlich, Matthew T. James, Gilaad G. Kaplan, Michael J. Bourke, Robert J. Hilsden, Steven J. Heitman, Nauzer Forbes
Surgical Endoscopy.2022; 36(2): 1251. CrossRef - Establishment of a model for predicting delayed post-polypectomy bleeding: A real-world retrospective study
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- The Use of Clips to Prevent Post-Polypectomy Bleeding: A Clinical Review
- 18,935 View
- 85 Download
- 37 Web of Science
- 33 Crossref
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