Intestinal Research

Original Articles

High C-reactive protein level is associated with high-risk adenoma: Hyae Min Lee, Jae Myung Cha, Jung Lok Lee, Jung Won Jeon, Hyun Phil Shin, Kwang Ro Joo, Jin Young Yoon, Joung Il Lee; Intest Res 2017;15(4):511-517. Published online October 23, 2017; DOI: https://doi.org/10.5217/ir.2017.15.4.511

Background/Aims

There is substantial evidence supporting a role of inflammation in the pathogenesis of colorectal cancer; however, little is known about the association between serum C-reactive protein (CRP) and the risk of colorectal adenoma. This study was conducted to investigate the association between serum CRP and colorectal adenoma risk.

Methods

A retrospective cross-sectional study was performed on first-time screening colonoscopies in asymptomatic subjects who also had their serum CRP level measured during a routine health check-up between September 2006 and September 2009 in Korea. Serum CRP level was compared between high-risk and low-risk adenoma groups and independent predictors of high-risk adenoma were analyzed using multivariate regression analysis.

Results

Among the 3,309 eligible patients, the high-risk adenoma group had higher serum CRP levels than the low-risk adenoma group (P=0.000). In addition, patients with a high-risk adenoma were more frequently included in the high CRP group than in the low CRP group (8.6% vs. 4.0%, P<0.001). The prevalence of high-risk adenoma was 3.5 times higher in the highest quartile of CRP level (P=0.000) compared with that in the lowest quartile. In logistic regression analysis, a higher quartile CRP level was found to be an independent risk factor for high-risk adenoma (odds ratio, 1.8; 95% confidence interval, 1.3–2.5; P=0.000).

Conclusions

High CRP level is associated with high-risk adenoma in both men and women. Our data may support the association between chronic inflammation and colorectal neoplasia, which warrants further investigation.

Citations

Citations to this article as recorded by

Short-term and residential exposure to air pollution: Associations with inflammatory biomarker levels in adults living in northern France
Marion Darras-Hostens, Djamal Achour, Manon Muntaner, Céline Grare, Gianni Zarcone, Guillaume Garçon, Philippe Amouyel, Farid Zerimech, Régis Matran, Jean-Marc Lo Guidice, Luc Dauchet
Science of The Total Environment.2022; 833: 154985. CrossRef
Functional Plasmon-Activated Water Increases Akkermansia muciniphila Abundance in Gut Microbiota to Ameliorate Inflammatory Bowel Disease
Chun-Chao Chang, Chih-Yi Liu, I-Chia Su, Yuarn-Jang Lee, Hsing-Jung Yeh, Wen-Chao Chen, Chih-Jui Yu, Wei-Yu Kao, Yu-Chuan Liu, Chi-Jung Huang
International Journal of Molecular Sciences.2022; 23(19): 11422. CrossRef
Self-reported Metabolic Risk Factor Associations with Adenomatous, Sessile Serrated, and Synchronous Adenomatous and Sessile Serrated Polyps
Celina N. Santiago, Samara Rifkin, Julia Drewes, Gerard Mullin, Emma Spence, Linda M. Hylind, Joell J. Gills, David Kafonek, David M. Cromwell, Louis La Luna, Francis Giardello, Cynthia L. Sears
Cancer Prevention Research.2021; 14(7): 697. CrossRef
Single‐incision laparoscopic colectomy for ascending colon tumor with relapsing polychondritis
Ryugo Teranishi, Norikatsu Miyoshi, Kansuke Kido, Masayuki Nishide, Shiki Fujino, Takayuki Ogino, Hidekazu Takahashi, Mamoru Uemura, Chu Matsuda, Tsunekazu Mizusima, Masaki Mori, Yuichiro Doki
Asian Journal of Endoscopic Surgery.2020; 13(4): 569. CrossRef
Increased Th17-Related Cytokine Serum Levels in Patients With Multiple Polyps of Unexplained Origin
Miren Alustiza, Eva Hernández-Illán, Miriam Juárez, Mar Giner-Calabuig, Cristina Mira, Alejandro Martínez-Roca, Luis Bujanda, Francisco Rodríguez-Moranta, Joaquín Cubiella, Luisa de-Castro, José-Carlos Marín-Gabriel, Alberto Herreros-de-Tejada, Fernando F
Clinical and Translational Gastroenterology.2020; 11(3): e00143. CrossRef

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5 Web of Science
5 Crossref

Determining the optimal surveillance interval after a colonoscopic polypectomy for the Korean population?: Jung Lok Lee, Jae Myung Cha, Hye Min Lee, Jung Won Jeon, Min Seob Kwak, Jin Young Yoon, Hyun Phil Shin, Kwang Ro Joo, Joung Il Lee, Dong Il Park; Intest Res 2017;15(1):109-117. Published online January 31, 2017; DOI: https://doi.org/10.5217/ir.2017.15.1.109

Abstract PDF PubReader ePub

Background/Aims

Western surveillance strategies cannot be directly adapted to the Korean population. The aim of this study was to estimate the risk of metachronous neoplasia and the optimal surveillance interval in the Korean population.

Methods

Clinical and pathological data from index colonoscopy performed between June 2006 and July 2008 and who had surveillance colonoscopies up to May 2015 were compared between low- and high-risk adenoma (LRA and HRA) groups. The 3- and 5-year cumulative risk of metachronous colorectal neoplasia in both groups were compared.

Results

Among 895 eligible patients, surveillance colonoscopy was performed in 399 (44.6%). Most (83.3%) patients with LRA had a surveillance colonoscopy within 5 years and 70.2% of patients with HRA had a surveillance colonoscopy within 3 years. The cumulative risk of metachronous advanced adenoma was 3.2% within 5 years in the LRA group and only 1.7% within 3 years in the HRA group. The risk of metachronous neoplasia was similar between the surveillance interval of <5 and ≥5 years in the LRA group; however, it was slightly higher at surveillance interval of ≥3 than <3 years in the HRA group (9.4% vs. 2.4%). In multivariate analysis, age and the ≥3-year surveillance interval were significant independent risk factors for metachronous advanced adenoma (P=0.024 and P=0.030, respectively).

Conclusions

Patients had a surveillance colonoscopy before the recommended guidelines despite a low risk of metachronous neoplasia. However, the risk of metachronous advanced adenoma was increased in elderly patients and those with a ≥3-year surveillance interval.

Citations

Citations to this article as recorded by

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British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland/Public Health England post-polypectomy and post-colorectal cancer resection surveillance guidelines
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Gut.2020; 69(2): 201. CrossRef
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Eun Ran Kim, Hyuk Nam Kwon, Hoonsik Nam, Jae J. Kim, Sunghyouk Park, Young-Ho Kim
Scientific Reports.2019;[Epub] CrossRef
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Gastrointestinal Endoscopy.2018; 88(4): 715. CrossRef
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Moon Joo Hwang, Kyeong Ok Kim, A Lim Kim, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
Intestinal Research.2018; 16(3): 475. CrossRef
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Jin Young Yoon, Jae Myung Cha, Yoon Tae Jeen
Intestinal Research.2018; 16(1): 48. CrossRef

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11 Web of Science
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Case Report

Anaphylactic Shock Caused by Ingestion of Polyethylene Glycol: Sun Hee Lee, Jae Myung Cha, Joung Il Lee, Kwang Ro Joo, Hyun Phil Shin, Il Hyun Baek, Jung Won Jeon, Jun Uk Lim, Jung Lok Lee, Hyae Min Lee, Young-Hak Cho; Intest Res 2015;13(1):90-94. Published online January 29, 2015; DOI: https://doi.org/10.5217/ir.2015.13.1.90

Abstract PDF PubReader

Colonoscopy is the current standard method for evaluation of the colon. The diagnostic accuracy and therapeutic safety of colonoscopy depend on the quality of colonic cleansing and preparation. Generally, all these preparations have been demonstrated to be safe for use in healthy individuals without significant comorbid conditions. Based on safety and efficacy concerns, polyethylene glycol (PEG) is most commonly utilized as a bowel preparation solution for colonoscopy. Adverse events in patients receiving PEG are mostly clinically non-significant. However, fatal adverse events rarely have been shown to occur in the few individuals who experience vomiting or aspiration. Anaphylactic shock associated with ingestion of PEG electrolyte solution is an extremely rare fatal complication, and reported mainly in Western countries. Here, we report the first case of anaphylactic shock following the ingestion of PEG solution in Korea.

Citations

Citations to this article as recorded by

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Annals of Allergy, Asthma & Immunology.2019; 123(3): 302. CrossRef
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Anaphylaxis During Intracardiac and Endovascular Implantations: A Multifactorial Problem Involving Kounis Syndrome
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Journal of Cardiothoracic and Vascular Anesthesia.2017; 31(3): 804. CrossRef
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Clinical & Experimental Allergy.2016; 46(7): 907. CrossRef
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So-Hee Lee, Sun Hyuk Hwang, Jin Soo Park, Hae-Sim Park, Yoo Seob Shin
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11,480 View
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19 Web of Science
16 Crossref

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