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IBD
Rapid prediction of 1-year efficacy of tofacitinib for treating refractory ulcerative colitis
Hiromichi Shimizu, Toshimitsu Fujii, Shuji Hibiya, Maiko Motobayashi, Kohei Suzuki, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
Intest Res 2021;19(1):115-118.   Published online June 11, 2020
DOI: https://doi.org/10.5217/ir.2020.00030
PDFSupplementary MaterialPubReaderePub

Citations

Citations to this article as recorded by  
  • Comparative short-term efficacy of upadacitinib versus tofacitinib for ulcerative colitis: a 24-week real-world study in Japan
    Akiko Tamura, Hiromichi Shimizu, Toshimitsu Fujii, Ami Kawamoto, Ryo Morikawa, Shuji Hibiya, Kento Takenaka, Masakazu Nagahori, Kazuo Ohtsuka, Ryuichi Okamoto
    Intestinal Research.2026; 24(1): 95.     CrossRef
  • Tofacitinib safety in inflammatory bowel disease: a disproportionality analysis of the FDA adverse event reporting system
    Suqi Zeng, Sihan Zhang, Jianxuan Sun, Junjie Chen
    Naunyn-Schmiedeberg's Archives of Pharmacology.2026;[Epub]     CrossRef
  • Inflammatory bowel disease therapeutics: a bibliometric analysis of tofacitinib research in ulcerative colitis
    Jianping Zhou, Yuting Xi, Yaping Zhang, Rui Zhang, Hao Fu, Ce Zhou
    Frontiers in Pharmacology.2025;[Epub]     CrossRef
  • Association between inflammatory bowel disease, current therapies, and cardiovascular events: a review and meta-analysis of data from 2.2 million individuals
    David-Raj Thomas, Gavin Huangfu, Fiona Yeaman, Sara Sukudom, Nick S R Lan, Girish Dwivedi, Lena Thin
    Journal of Crohn's and Colitis.2025;[Epub]     CrossRef
  • Toward Precision Medicine: Molecular Biomarkers of Response to Tofacitinib in Inflammatory Bowel Disease
    Anja Bizjak, Boris Gole, Gregor Jezernik, Uroš Potočnik, Mario Gorenjak
    Genes.2025; 16(8): 908.     CrossRef
  • Histological healing induced by tofacitinib in ulcerative colitis: A multicentre study
    Sophie Vieujean, David Laharie, Anthony Buisson, Xavier Roblin, Mathurin Fumery, Stephane Nancey, Pauline Wils, Romain Altwegg, Laurence Seidel, Bénédicte Caron, Laurent Peyrin-Biroulet
    Digestive and Liver Disease.2024; 56(4): 613.     CrossRef
  • Continued JAK inhibitor treatment on the risk of recurrent herpes zoster reactivation in patients with immune-mediated inflammatory diseases: A nationwide population-based study in South Korea
    Young-Eun Kim, Ye-Jee Kim, Dae Hyun Jeong, Seonok Kim, Min Jee Kim, Hyeon Hwa Kim, Kyung-Wook Jo, Sang Hyoung Park, Seokchan Hong
    Seminars in Arthritis and Rheumatism.2024; 65: 152362.     CrossRef
  • Preventing and managing cardiovascular events in patients with inflammatory bowel diseases treated with small-molecule drugs, an international Delphi consensus
    Pablo A. Olivera, Axel Dignass, Marla C. Dubinsky, Giovanni Peretto, Paulo G. Kotze, Iris Dotan, Taku Kobayashi, Subrata Ghosh, Fernando Magro, Jose Rocha Faria-Neto, Britta Siegmund, Silvio Danese, Laurent Peyrin-Biroulet
    Digestive and Liver Disease.2024; 56(8): 1270.     CrossRef
  • Long-term efficacy and safety of tofacitinib in patients with ulcerative colitis: 3-year results from a real-world study
    Hiromichi Shimizu, Yuko Aonuma, Shuji Hibiya, Ami Kawamoto, Kento Takenaka, Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Ryuichi Okamoto
    Intestinal Research.2024; 22(3): 369.     CrossRef
  • Safety and effectiveness of tofacitinib in Korean adult patients with ulcerative colitis: post-marketing surveillance study
    Hyuk Yoon, Byong Duk Ye, Sang-Bum Kang, Kang-Moon Lee, Chang Hwan Choi, Joo-young Jo, Juwon Woo, Jae Hee Cheon
    BMC Gastroenterology.2024;[Epub]     CrossRef
  • Effectiveness of tofacitinib in patients with ulcerative colitis: an updated systematic review and meta-analysis of real-world studies
    Chien-Hung Lin, Wen-Sheng Liu, Chuan Wan, Hsin-Hui Wang
    BMJ Open Gastroenterology.2024; 11(1): e001347.     CrossRef
  • Real-World Evidence of Tofacinitib in Ulcerative Colitis: Short-Term and Long-Term Effectiveness and Safety
    María Chaparro, Diana Acosta, Cristina Rodríguez, Francisco Mesonero, Miren Vicuña, Manuel Barreiro-de Acosta, Agnès Fernández-Clotet, Álvaro Hernández Martínez, Maite Arroyo, Isabel Vera, Alexandra Ruiz-Cerulla, Beatriz Sicilia, M. José Cabello Tapia, Ca
    American Journal of Gastroenterology.2023; 118(7): 1237.     CrossRef
  • Real-life effectiveness and safety of tofacitinib treatment in patients with ulcerative colitis: a KASID multicenter cohort study
    Seung Hwan Shin, Kyunghwan Oh, Sung Noh Hong, Jungbok Lee, Shin Ju Oh, Eun Soo Kim, Soo-Young Na, Sang-Bum Kang, Seong-Joon Koh, Ki Bae Bang, Sung-Ae Jung, Sung Hoon Jung, Kyeong Ok Kim, Sang Hyoung Park, Suk-Kyun Yang, Chang Hwan Choi, Byong Duk Ye
    Therapeutic Advances in Gastroenterology.2023;[Epub]     CrossRef
  • Review article: Risk of cardiovascular events in patients with inflammatory bowel disease receiving small molecule drugs
    Pablo A. Olivera, Juan S. Lasa, Giovanni Peretto, Stephane Zuily, Silvio Danese, Laurent Peyrin‐Biroulet
    Alimentary Pharmacology & Therapeutics.2023; 57(11): 1231.     CrossRef
  • Positioning of tofacitinib in treatment of ulcerative colitis: a global perspective
    Shubhra Mishra, Anuraag Jena, Rinkalben Kakadiya, Vishal Sharma, Vineet Ahuja
    Expert Review of Gastroenterology & Hepatology.2022; 16(8): 737.     CrossRef
  • Oral beclomethasone dipropionate as an add-on therapy and response prediction in Korean patients with ulcerative colitis
    Kyuwon Kim, Hee Seung Hong, Kyunghwan Oh, Jae Yong Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye, Sang Hyoung Park
    The Korean Journal of Internal Medicine.2022; 37(6): 1140.     CrossRef
  • Review article: guide to tofacitinib dosing in patients with ulcerative colitis
    Peter M. Irving, Yvette Leung, Marla C. Dubinsky
    Alimentary Pharmacology & Therapeutics.2022; 56(7): 1131.     CrossRef
  • Management of inflammatory bowel disease beyond tumor necrosis factor inhibitors: novel biologics and small-molecule drugs
    Soo-Young Na, You Sun Kim
    The Korean Journal of Internal Medicine.2022; 37(5): 906.     CrossRef
  • Effectiveness and Safety of Tofacitinib for Ulcerative Colitis
    Vikas Taneja, Mohammed El-Dallal, Zadid Haq, Kartikeya Tripathi, Hannah K. Systrom, Linda F. Wang, Hyder Said, Paul A. Bain, Youlian Zhou, Joseph D. Feuerstein
    Journal of Clinical Gastroenterology.2022; 56(10): e323.     CrossRef
  • Real-world experience with tofacitinib in ulcerative colitis: a systematic review and meta-analysis
    Laura A. Lucaciu, Nathan Constantine-Cooke, Nikolas Plevris, Spyros Siakavellas, Lauranne A.A.P. Derikx, Gareth-Rhys Jones, Charles W. Lees
    Therapeutic Advances in Gastroenterology.2021;[Epub]     CrossRef
  • 9,370 View
  • 268 Download
  • 23 Web of Science
  • 20 Crossref
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Review
IBD
Stem cell-based therapy for inflammatory bowel disease
Hiromichi Shimizu, Kohei Suzuki, Mamoru Watanabe, Ryuichi Okamoto
Intest Res 2019;17(3):311-316.   Published online July 25, 2019
DOI: https://doi.org/10.5217/ir.2019.00043
AbstractAbstract PDFPubReaderePub
Inflammatory bowel disease (IBD) is an idiopathic, multi-etiological disease characterized by inflammation and mucosal destruction of the gastrointestinal tract. Despite the remarkable advance in immunomodulating therapies, there still remains a certain population of patients who are refractory to conventional as well as biologic therapies and fail to achieve mucosal healing. To improve the prognosis of those patients, at least 2 types of stem cells have been tested for their potential therapeutic use. Transplantation of hematopoietic stem cells or mesenchymal stem cells have been tested in several clinical studies, but their beneficial effect still remains controversial. In this review, we would like to overview the recent clinical challenges of stem cell-based therapies in IBD and also introduce our new therapeutic plan of intestinal stem cell transplantation for IBD, based on our ex vivo intestinal organoid culture technique.

Citations

Citations to this article as recorded by  
  • Mesenchymal stem cell-derived exosomes as a plausible immunomodulatory therapeutic tool for inflammatory diseases
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    Frontiers in Cell and Developmental Biology.2025;[Epub]     CrossRef
  • Myths and Realities about the Private Sector Stem Cell Industry in Malaysia
    Kean Chang Phang, Mohammad Firdaus Bin Abdul Aziz
    Asian Bioethics Review.2025; 17(4): 729.     CrossRef
  • Optimizing Wnt activation in fetal calf serum (FCS)-free organoid expansion media
    Esther J. M. Liefting, Jeffrey J. Bajramovic
    Frontiers in Toxicology.2025;[Epub]     CrossRef
  • From bench to bedside: the role of gastrointestinal stem cells in health and disease
    Xiaopeng Bai, Eikichi Ihara, Yoshimasa Tanaka, Yosuke Minoda, Masafumi Wada, Yoshitaka Hata, Mitsuru Esaki, Haruei Ogino, Takatoshi Chinen, Yoshihiro Ogawa
    Inflammation and Regeneration.2025;[Epub]     CrossRef
  • Cell-derived vesicles extruded from adipose mesenchymal stem cells attenuate intestinal inflammation and augment epithelial regeneration in a colitis model
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    Nanoscale.2025; 17(47): 27337.     CrossRef
  • The nasal basal cell population shifts toward a diseased phenotype with impaired barrier formation capacity in allergic rhinitis
    Emma Ruysseveldt, Brecht Steelant, Tine Wils, Jonathan Cremer, Dominique M.A. Bullens, Peter W. Hellings, Katleen Martens
    Journal of Allergy and Clinical Immunology.2024; 154(3): 631.     CrossRef
  • Cellular Plasticity in Gut and Liver Regeneration
    Minwook Kim, Yoojeong Park, You Sun Kim, Sungjin Ko
    Gut and Liver.2024; 18(6): 949.     CrossRef
  • Revolutionizing medicine: recent developments and future prospects in stem-cell therapy
    Bashdar M. Hussen, Mohammad Taheri, Raya Kh. Yashooa, Gaylany H. Abdullah, Snur R. Abdullah, Ramiar Kamal Kheder, Suhad A. Mustafa
    International Journal of Surgery.2024; 110(12): 8002.     CrossRef
  • Nigakinone alleviates DSS‐induced experimental colitis via regulating bile acid profile and FXR/NLRP3 signaling pathways
    Fangle Liu, Yufeng Yao, Qian Wang, Fengxue Zhang, Meiqi Wang, Chenchen Zhu, Chaozhan Lin
    Phytotherapy Research.2023; 37(1): 15.     CrossRef
  • TNFα Induces LGR5+ Stem Cell Dysfunction In Patients With Crohn’s Disease
    Chansu Lee, Minae An, Je-Gun Joung, Woong-Yang Park, Dong Kyung Chang, Young-Ho Kim, Sung Noh Hong
    Cellular and Molecular Gastroenterology and Hepatology.2022; 13(3): 789.     CrossRef
  • Bovine colostrum derived-exosomes prevent dextran sulfate sodium-induced intestinal colitis via suppression of inflammation and oxidative stress
    Geonhee Han, Haeun Cho, Hyosuk Kim, Yeongji Jang, Hochung Jang, Da Eun Kim, Eun Sun Kim, Eun Hye Kim, Kwang Yeon Hwang, Kwangmeyung Kim, Yoosoo Yang, Sun Hwa Kim
    Biomaterials Science.2022; 10(8): 2076.     CrossRef
  • The therapeutic potential of stem cell-derived exosomes in the ulcerative colitis and colorectal cancer
    Gang Guo, Zhaobang Tan, Yaping Liu, Feiyu Shi, Junjun She
    Stem Cell Research & Therapy.2022;[Epub]     CrossRef
  • Mesenchymal stem/stromal cells in the pathogenesis and regenerative therapy of inflammatory bowel diseases
    Zhengping Che, Ziyu Ye, Xueying Zhang, Bihua Lin, Weiqing Yang, Yanfang Liang, Jincheng Zeng
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Mechanotransduction through adhesion molecules: Emerging roles in regulating the stem cell niche
    Ryan Lim, Avinanda Banerjee, Ritusree Biswas, Anana Nandakumar Chari, Srikala Raghavan
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • Clinical applications and optimization of patient-derived organoids in intestinal diseases
    Tae Il Kim
    Organoid.2022; 2: e22.     CrossRef
  • Effects of human induced pluripotent stem cell-derived intestinal organoids on colitis-model mice
    Anna Nakanishi, Satoshi Toyama, Daichi Onozato, Chihiro Watanabe, Tadahiro Hashita, Takahiro Iwao, Tamihide Matsunaga
    Regenerative Therapy.2022; 21: 351.     CrossRef
  • Therapeutic Advances in Diabetes, Autoimmune, and Neurological Diseases
    Jinsha Liu, Joey Paolo Ting, Shams Al-Azzam, Yun Ding, Sepideh Afshar
    International Journal of Molecular Sciences.2021; 22(6): 2805.     CrossRef
  • Comparative perianal fistula closure rates following autologous adipose tissue-derived stem cell transplantation or treatment with anti-tumor necrosis factor agents after seton placement in patients with Crohn’s disease: a retrospective observational stud
    Min Young Park, Yong Sik Yoon, Jong Lyul Lee, Sang Hyoung Park, Byong Duk Ye, Suk-Kyun Yang, Chang Sik Yu
    Stem Cell Research & Therapy.2021;[Epub]     CrossRef
  • Current Trends and Research Topics Regarding Intestinal Organoids: An Overview Based on Bibliometrics
    Meng-Meng Zhang, Ke-Lu Yang, Yan-Cheng Cui, Yu-Shi Zhou, Hao-Ran Zhang, Quan Wang, Ying-Jiang Ye, Shan Wang, Ke-Wei Jiang
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • The Potential of Vitamin D3 to Repaired Mucosal Injury in Dextran Sulfate Sodium Induced Acute Colitis in Mice
    Satrio Wibowo, Krisni Subandiyah, Kusworini Handono, Sri Poeranto
    Open Access Macedonian Journal of Medical Sciences.2021; 9(B): 931.     CrossRef
  • Pharmacogenetics-based personalized treatment in patients with inflammatory bowel disease: A review
    Ji Young Chang, Jae Hee Cheon
    Precision and Future Medicine.2021; 5(4): 151.     CrossRef
  • Mutual regulation between butyrate and hypoxia‐inducible factor‐1α in epithelial cell promotes expression of tight junction proteins
    Jiuheng Yin, Chao Zhou, Kunqiu Yang, Yanbei Ren, Yuan Qiu, Pengyuan Xu, Weidong Xiao, Hua Yang
    Cell Biology International.2020; 44(6): 1405.     CrossRef
  • Letter: off‐label use of hyperbaric oxygen therapy in inflammatory bowel disease—Authors’ reply
    Melek Simsek, Nanne K. H. de Boer
    Alimentary Pharmacology & Therapeutics.2020; 52(1): 216.     CrossRef
  • The Role of Immune and Epithelial Stem Cells in Inflammatory Bowel Disease Therapy
    Agata Binienda, Sylwia Ziolkowska, Ingvild H. Hauge, Maciej Salaga
    Current Drug Targets.2020; 21(14): 1405.     CrossRef
  • 12,463 View
  • 277 Download
  • 24 Web of Science
  • 24 Crossref
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