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- Antinuclear antibodies seroconversion and endoscopic response to infliximab in biologic-naive Crohn’s disease: a Chinese single-center, retrospective study
- Jinlu Tong, Xitao Xu, Yuan Cao, Mingming Zhu, Juntao Lu, Yuqi Qiao, Zhanghan Dai, Tianrong Wang, Ying Sun, Zhijun Cao, Shen Jun
- Intest Res 2026;24(2):376-383. Published online November 14, 2025
- DOI: https://doi.org/10.5217/ir.2025.00018
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Abstract
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ePub - Background/Aims
The development of antinuclear antibodies (ANAs) during infliximab treatment has been observed in previous clinical trials. To evaluate the clinical significance of ANA seroconversion and its potential association with the formation of antibodies against infliximab.
Methods
This retrospective study included 130 Crohn’s disease patients undergoing infliximab therapy. ANA titers were measured at baseline and after 6 months of treatment. Inverse probability of treatment weighting was applied to control for confounding variables.
Results
Among the 111 patients with negative baseline ANA, 36 (32.4%) developed ANA positivity after 6 months of infliximab treatment. After adjustment with inverse probability of treatment weighting, a significantly higher proportion of patients in the ANA non-seroconversion group achieved endoscopic remission at 6 months compared to those with ANA seroconversion (64.5% vs. 35.5%: adjusted odds ratio [aOR], 3.61; 95% confidence interval [CI], 1.30–10.02; P= 0.014). At 18 months, patients in the non-seroconversion group also exhibited higher rates of both endoscopic response (57.5% vs. 42.3%: aOR, 3.38; 95% CI, 1.15–9.96; P= 0.027) and endoscopic remission (60.0% vs. 40.1%: aOR, 2.91; 95% CI, 1.06–8.01; P= 0.039) compared to the seroconversion group. Additionally, patients who developed ANA seroconversion had a higher rate of detectable antibodies against infliximab at both 6 and 18 months. A multivariable analysis identified female sex, older age at diagnosis, and lower serum albumin levels as independent predictors of ANA seroconversion at 6 months.
Conclusions
ANA non-seroconversion at 6 months was associated with higher rates of endoscopic remission and a lower likelihood of developing antibodies against infliximab.
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- 162 Download
- Status of serum vitamin B12 and folate in patients with inflammatory bowel disease in China
- Shaozhong Huang, Jiayi Ma, Mingming Zhu, Zhihua Ran
- Intest Res 2017;15(1):103-108. Published online January 31, 2017
- DOI: https://doi.org/10.5217/ir.2017.15.1.103
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Abstract
PDFPubReaderePub
<b>Background/Aims</b><br/> Inflammatory bowel disease (IBD) primarily involves the intestinal tract and can affect vitamin absorption. This study was designed to assess the prevalence of vitamin B12 and folate deficiencies in patients with IBD, and to identify the risk factors associated with abnormal serum vitamin B12 and folate levels.
Methods We evaluated the medical records of 195 patients with Crohn's disease (CD) and 62 patients with ulcerative colitis (UC), and selected 118 healthy subjects for the control group.
Results There were more CD patients with vitamin B12 deficiency than UC patients (14.9% vs. 3.2%,
P =0.014) and controls (14.9% vs. 4.2%,P =0.003). The prevalence of folate deficiency was higher in CD patients than in controls (13.3% vs. 3.4%,P =0.004). There were no significant differences in the serum vitamin B12 and folate statuses of the UC and control groups. Patients with prior ileal or ileocolic resection showed a higher prevalence of abnormal vitamin B12 levels than those without prior resection (n=6/16, n=23/179;P =0.018). A disease duration within 5 years was a risk factor of abnormal folate levels in CD patients.Conclusions This study showed that vitamin B12 and folate deficiencies were more common in patients with CD than in UC patients and controls. Prior ileal or ileocolonic resection was a risk factor of serum vitamin B12 abnormalities, and a disease duration within 5 years was a risk factor of low serum folate levels in CD patients.
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Citations
Citations to this article as recorded by
- Diet and Gut Microbiota in Inflammatory Bowel Disease: A Clinical and Nutritional Perspective
Luisa Bertin, Sonia Facchin, Brigida Barberio, Daria Maniero, Greta Lorenzon, Francesco Cesaroni, Miriana Zanconato, Giulia Romanelli, Francesco Francini-Pesenti, Luca Busetto, Mara Cananzi, Paola Gaio, Luca Bosa, Fabiana Zingone, Laura Gianolio, Oriana M
Pharmaceuticals.2026; 19(2): 318. CrossRef - Evaluation of serum and dietary profiles of vitamin B12 and folate and their association with systemic complications in patients with Crohn’s disease
Marina Moreira de Castro, Vitor Nascimento dos Santos, Maysa Santos Gomes, Aline Dias Gonçalves Ferraz, Leticia Martins Ignacio-Souza, Marcio Alberto Torsoni, Adriana Souza Torsoni, Maria de Lourdes Setsuko Ayrizono, Raquel Franco Leal, Ligiana Pires Coro
European Journal of Clinical Nutrition.2026; 80(5): 498. CrossRef - The Influence of Crohn’s Disease on Folic Acid Absorption by Small Intestinal Villi: Modeling and Simulation
Mengcheng Yao, Hong Zhu, Jie Xiao
Applied Sciences.2026; 16(8): 3724. CrossRef - Molecular Mechanisms Underlying the Higher Prevalence of Anemia in Crohn’s Disease Compared with Ulcerative Colitis: A Systematic Review
Dragos-Florin Tesoi, Laura Mihaela Trandafir, Laura Bozomitu, Otilia Elena Frasinariu, Nina Filip, Cornelia Mircea, Monica Hancianu, Oana-Viola Badulescu
International Journal of Molecular Sciences.2026; 27(12): 5570. CrossRef - Inpatient Outcomes of Pulmonary Embolism in Patients with Inflammatory Bowel Disease: Insights from a Nationwide Analysis
Uday Sankar Akash Vankayala, Chloe Lahoud, Bivin George, Ali Sohail, Bahy Abofrekha, John Afif, Omar Abureesh, Suzanne El-Sayegh, Hassan Al Moussawi
Journal of Clinical Medicine.2026; 15(14): 5328. CrossRef - Anemia in inflammatory bowel disease—A comprehensive review
Amit Kumar Dutta, Hemanth Chinthala, John Titus George, David Mathew Thomas, Anjilivelil Joseph Joseph
Indian Journal of Gastroenterology.2025; 44(4): 430. CrossRef - Integrated Macrogenomics and Metabolomics Analysis of the Effect of Sea Cucumber Ovum Hydrolysates on Dextran Sodium Sulfate-Induced Colitis
Shunmin Gong, Liqin Sun, Yongjun Sun, Wenming Ju, Gongming Wang, Jian Zhang, Xuejun Fu, Chang Lu, Yu Zhang, Wenkui Song, Mingbo Li, Leilei Sun
Marine Drugs.2025; 23(2): 73. CrossRef - B vitamins as a potential nutritional approach to fatigue management in inflammatory bowel disease: a systematic review
Naheed Aryaeian, Negin Tahvilian, Azadeh Heydarian, Ali Nouri, Mehrnaz Morvaridi
Nutrire.2025;[Epub] CrossRef - Fatigue in children and adolescents with inflammatory bowel disease: a cross-sectional study
Yahui Zuo, Jinjin Cao, Yuanyuan Wang, Wenqian Cai, Mei Li
Frontiers in Pediatrics.2024;[Epub] CrossRef - Role of micronutrients in inflammatory bowel disease
Wen-Xuan Song, Zi-Han Yu, Xiang-Feng Ren, Ji-Hua Chen, Xin Chen
World Chinese Journal of Digestology.2023; 31(17): 711. CrossRef - Review article: The complex interplay between diet and Escherichia coli in inflammatory bowel disease
Nojoud Faqerah, Daniel Walker, Konstantinos Gerasimidis
Alimentary Pharmacology & Therapeutics.2023; 58(10): 984. CrossRef - Group B Vitamins: From Homeostasis to Pathogenesis and Treatment of Multiple Sclerosis
I. N. Abdurasulova, A. V. Dmitriev
Успехи физиологических наук.2023; 54(1): 26. CrossRef - An assessment of serum vitamin B12 and folate in patients with Crohn’s disease
Sabiye Akbulut
Medicine.2022; 101(50): e31892. CrossRef - A food pyramid, based on a review of the emerging literature, for subjects with inflammatory bowel disease
Mariangela Rondanelli, Silvia Lamburghini, Milena A. Faliva, Gabriella Peroni, Antonella Riva, Pietro Allegrini, Daniele Spadaccini, Clara Gasparri, Giancarlo Iannello, Vittoria Infantino, Tariq A. Alalwan, Simone Perna, Alessandra Miccono
Endocrinología, Diabetes y Nutrición.2021; 68(1): 17. CrossRef - A food pyramid, based on a review of the emerging literature, for subjects with inflammatory bowel disease
Mariangela Rondanelli, Silvia Lamburghini, Milena A. Faliva, Gabriella Peroni, Antonella Riva, Pietro Allegrini, Daniele Spadaccini, Clara Gasparri, Giancarlo Iannello, Vittoria Infantino, Tariq A. Alalwan, Simone Perna, Alessandra Miccono
Endocrinología, Diabetes y Nutrición (English ed.).2021; 68(1): 17. CrossRef - Review article: The aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies
Jordan J. McGing, Shellie Jean Radford, Susan T. Francis, Sébastien Serres, Paul L. Greenhaff, Gordon W. Moran
Alimentary Pharmacology & Therapeutics.2021; 54(4): 368. CrossRef - Nutritional supplementation for vitamin B12 and vitamin K2 deficiency following ileostomy or colostomy formation
David Mantle
Gastrointestinal Nursing.2020; 18(Sup4): S12. CrossRef - Nutrients in the Prevention of Osteoporosis in Patients with Inflammatory Bowel Diseases
Alicja Ewa Ratajczak, Anna Maria Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak
Nutrients.2020; 12(6): 1702. CrossRef - Methyl-donor supplementation prevents intestinal colonization by Adherent-Invasive E. coli in a mouse model of Crohn’s disease
Elodie Gimier, Mélissa Chervy, Allison Agus, Adeline Sivignon, Elisabeth Billard, Maud Privat, Sandrine Viala, Régine Minet-Quinard, Anthony Buisson, Emilie Vazeille, Nicolas Barnich, Jérémy Denizot
Scientific Reports.2020;[Epub] CrossRef - Parkinson’s disease: Are gut microbes involved?
Yogesh Bhattarai, Purna C. Kashyap
American Journal of Physiology-Gastrointestinal and Liver Physiology.2020; 319(5): G529. CrossRef - Vitamin D deficiency is associated with disease activity in patients with Crohn’s disease
Kyoung Ho Ko, You Sun Kim, Bo Kyung Lee, Jong Hyun Choi, Yong Moon Woo, Jin Young Kim, Jeong Seop Moon
Intestinal Research.2019; 17(1): 70. CrossRef - Metagenomic analysis of microbe-mediated vitamin metabolism in the human gut microbiome
Promi Das, Parizad Babaei, Jens Nielsen
BMC Genomics.2019;[Epub] CrossRef - Effective Use of the Laboratory in the Management of Patients with Inflammatory Bowel Diseases
M. Nedim Ince, David E. Elliott
Gastroenterology Clinics of North America.2019; 48(2): 237. CrossRef
- Diet and Gut Microbiota in Inflammatory Bowel Disease: A Clinical and Nutritional Perspective
- 13,114 View
- 67 Download
- 22 Web of Science
- 23 Crossref
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