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Inflammatory bowel diseases
Risk Factors Associated with Impaired Ovarian Reserve in Young Women of Reproductive Age with Crohn’s Disease
Yue Zhao, Baili Chen, Yao He, Shenghong Zhang, Yun Qiu, Rui Feng, Hongsheng Yang, Zhirong Zeng, Shomron Ben-Horin, Minhu Chen, Ren Mao
Intest Res 2020;18(2):200-209.   Published online March 31, 2020
DOI: https://doi.org/10.5217/ir.2019.00103
AbstractAbstract PDFPubReaderePub
Background/Aims
Crohn’s disease (CD) primarily affects young female adults of reproductive age. Few studies have been conducted on this population’s ovarian reserve status. The aim of study was to investigate potential risk factors associated with low ovarian reserve, as reflected by serum anti-Müllerian hormone (AMH) in women of reproductive age with CD.
Methods
This was a case-control study. Cases included 87 patients with established CD, and healthy controls were matched by age, height and weight in a 1:1 ratio. Serum AMH levels were measured by enzyme-linked immunosorbent assay.
Results
The average serum AMH level was significantly lower in CD patients than in control group (2.47±2.08 ng/mL vs. 3.87±1.96 ng/mL, respectively, P<0.001). Serum AMH levels were comparable between CD patients and control group under 25 years of age (4.41±1.52 ng/mL vs. 3.49±2.10 ng/mL, P=0.06), however, serum AMH levels were significantly lower in CD patients over 25 years of age compared to control group (P<0.05). Multivariable analysis showed that an age greater than 25 (odds ratio [OR], 10.03; 95% confidence interval [CI], 1.90–52.93, P=0.007), active disease state (OR, 27.99; 95% CI, 6.13–127.95, P<0.001) and thalidomide use (OR, 15.66; 95% CI, 2.22–110.65, P=0.006) were independent risk factors associated with low ovarian reserve (serum AMH levels <2 ng/mL) in CD patients.
Conclusions
Ovarian reserve is impaired in young women of reproductive age with CD. Age over 25 and an active disease state were both independently associated with low ovarian reserve. Thalidomide use could result in impaired ovarian reserve.

Citations

Citations to this article as recorded by  
  • Efficacy and Tolerance of Thalidomide in Patients With Very Early Onset Inflammatory Bowel Disease
    Matteo Bramuzzo, Fabiola Giudici, Serena Arrigo, Paolo Lionetti, Giovanna Zuin, Claudio Romano, Francesco Graziano, Simona Faraci, Patrizia Alvisi, Sara Signa, Luca Scarallo, Stefano Martelossi, Grazia Di Leo
    Inflammatory Bowel Diseases.2024; 30(1): 20.     CrossRef
  • Inhibin B and antiMüllerian hormone as surrogate markers of fertility in male and female Crohn’s disease patients: a case-control study
    Ana Gutiérrez, Roser Muñoz-Pérez, Pedro Zapater, Cristina Mira, Andrés Rodríguez, Laura Sempere-Robles, María Eugenia Torregrosa, Rocio Alfayate, Violeta Moreno-Torres, Lorena Bernal, Olivia Belén-Galipienso, Jose Ignacio Cameo, Paula Sirera, Belen Herrer
    Frontiers in Medicine.2024;[Epub]     CrossRef
  • Factors associated with decreased ovarian reserve in Crohn's disease: A systematic review and meta‐analysis
    Arthur Foulon, Nicolas Richard, Camille Guichard, Clara Yzet, Coraline Breuval, Jean Gondry, Rosalie Cabry‐Goubet, Audrey Michaud, Mathurin Fumery
    Acta Obstetricia et Gynecologica Scandinavica.2024; 103(9): 1714.     CrossRef
  • Serum anti-mullerian hormone, sex hormone, and nutrient levels in reproductive age women with celiac disease
    Ailifeire Tuerxuntayi, Tian Shi, Beiyao Gao, Yan Feng, Ting Li, Wenjia Hui, Shenglong Xue, Feng Gao
    Journal of Assisted Reproduction and Genetics.2024; 41(8): 2129.     CrossRef
  • Inflammatory bowel disease can reduce ovarian reserve function in women: A systematic review and meta-analysis
    Lin Guo, Yi Liu, Jiansheng Li, Quan Liu, Bing Liu, Xuewen Shi
    Medicine.2023; 102(11): e33113.     CrossRef
  • Inflammatory bowel disease in pregnancy and breastfeeding
    Max N. Brondfield, Uma Mahadevan
    Nature Reviews Gastroenterology & Hepatology.2023; 20(8): 504.     CrossRef
  • Case report: A pregnant woman with Crohn disease who used ustekinumab to the 3rd trimester developed severe infection
    Peng Guo, Wulan Cao
    Medicine.2023; 102(48): e36253.     CrossRef
  • Monitoring of Inflammatory Bowel Disease in Pregnancy: A Review of the Different Modalities
    Reem Al-jabri, Panu Wetwittayakhlang, Peter L. Lakatos
    Journal of Clinical Medicine.2023; 12(23): 7343.     CrossRef
  • General review of pregnancy in inflammatory bowel disease
    Elena Santos Pérez, Marta Calvo Moya
    Revista Española de Enfermedades Digestivas.2022;[Epub]     CrossRef
  • Inflammatory Bowel Disease and Reproductive Health: From Fertility to Pregnancy—A Narrative Review
    Camilla Ronchetti, Federico Cirillo, Noemi Di Segni, Martina Cristodoro, Andrea Busnelli, Paolo Emanuele Levi-Setti
    Nutrients.2022; 14(8): 1591.     CrossRef
  • Ovarian reserve and IVF outcomes in patients with inflammatory bowel disease: A systematic review and meta-analysis
    Honghao Sun, Jiao Jiao, Feng Tian, Qing Liu, Jiansu Bian, Rongmin Xu, Da Li, Xiuxia Wang, Hong Shu
    eClinicalMedicine.2022; 50: 101517.     CrossRef
  • Inflammatory Bowel Disease and Pregnancy
    Eugenia Shmidt, Marla C. Dubinsky
    American Journal of Gastroenterology.2022; 117(10S): 60.     CrossRef
  • Reproductive Health in IBD Patients
    Sanket Patel, Haleh Vaziri
    Current Treatment Options in Gastroenterology.2021; 19(2): 237.     CrossRef
  • Ovarian Reserve Assessed by the Anti-Mullerian Hormone and Reproductive Health Parameters in Women With Crohn´s Disease, a Case-Control Study
    T. Koller, J. Kollerová, T. Hlavatý, B. Kadlečková, J. Payer
    Physiological Research.2021; : S69.     CrossRef
  • THE ROLE OF IMMUNOGLOBULIN A IN THE INFLAMMATORY PROCESS INVOLVING NEUTROPHILS
    O.O. Prudnikov, I.M. Prudnikov, V.M. Tsyvkin, A.M. Smirnov, R.I. Yanchiy
    Fiziolohichnyĭ zhurnal.2021; 67(5): 44.     CrossRef
  • Update on Pregnancy in Patients with IBD
    Rachel W. Winter, Sonia Friedman
    Current Treatment Options in Gastroenterology.2020; 18(3): 423.     CrossRef
  • 6,695 View
  • 130 Download
  • 14 Web of Science
  • 16 Crossref
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Surgical management of inflammatory bowel disease in China: a systematic review of two decades
Qiao Yu, Ren Mao, Lei Lian, Siew chien Ng, Shenghong Zhang, Zhihui Chen, Yanyan Zhang, Yun Qiu, Baili Chen, Yao He, Zhirong Zeng, Shomron Ben-Horin, Xinming Song, Minhu Chen
Intest Res 2016;14(4):322-332.   Published online October 17, 2016
DOI: https://doi.org/10.5217/ir.2016.14.4.322
AbstractAbstract PDFSupplementary MaterialPubReader
<b>Background/Aims</b><br/>

The past decades have seen increasing incidence and prevalence of inflammatory bowel disease (IBD) in China. This article aimed to summarize the current status and characteristics of surgical management for IBD in China.

Methods

We searched PubMed, Embase, and Chinese databases from January 1, 1990 to July 1, 2014 for all relevant studies on the surgical treatment IBD in China. Eligible studies with sufficient defined variables were further reviewed for primary and secondary outcome measures.

Results

A total of 74 studies comprising 2,007 subjects with Crohn's disease (CD) and 1,085 subjects with ulcerative colitis (UC) were included. The percentage of CD patients misdiagnosed before surgery, including misdiagnosis as appendicitis or UC, was 50.8%±30.9% (578/1,268). The overall postoperative complication rate was 22.3%±13.0% (267/1,501). For studies of UC, the overall postoperative complication rate was 22.2%±27.9% (176/725). In large research centers (n>50 surgical cases), the rates of emergency operations for CD (P=0.032) and in-hospital mortalities resulting from both CD and UC were much lower than those in smaller research centers (n≤50 surgical cases) (P=0.026 and P <0.001, respectively). Regarding the changes in CD and UC surgery over time, postoperative complications (P=0.045 for CD; P=0.020 for UC) and postoperative in-hospital mortality (P=0.0002 for CD; P=0.0160 for UC) both significantly improved after the year 2010.

Conclusions

The surgical management of IBD in China has improved over time. However, the rates of misdiagnosis and postoperative complications over the past two decades have remained high. Large research centers were found to have relatively better capacity for surgical management than the smaller ones. Higher quality prospective studies are needed in China.

Citations

Citations to this article as recorded by  
  • Epidemiological research, burden, and clinical advances of inflammatory bowel disease in China
    Hong Yang, Jiaming Qian
    Chinese Medical Journal.2024; 137(9): 1009.     CrossRef
  • Laparoscopic surgery contributes to a decrease in short-term complications in surgical ulcerative colitis patients during 2008–2017: a multicenter retrospective study in China
    Zerong Cai, Xiaosheng He, Jianfeng Gong, Peng Du, Wenjian Meng, Wei Zhou, Jinbo Jiang, Bin Wu, Weitang Yuan, Qi Xue, Lianwen Yuan, Jinhai Wang, Jiandong Tai, Jie Liang, Weiming Zhu, Ping Lan, Xiaojian Wu
    Intestinal Research.2023; 21(2): 235.     CrossRef
  • Differences in inflammatory bowel diseases between East and West: a Chinese perspective
    Guanglin Cui, Junling Li, Hanzhe Liu, Jann-Birger Laugsand, Zhanju Liu
    Journal of Public Health.2021; 29(1): 19.     CrossRef
  • Diagnostic and Predictive Value of Immune-Related Genes in Crohn’s Disease
    Bing Yu, Yi-xin Yin, Yan-ping Tang, Kang-lai Wei, Zhi-gang Pan, Ke-Zhi Li, Xian-wen Guo, Bang-li Hu
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Role of a multidisciplinary team (MDT) in the diagnosis, treatment, and outcomes of inflammatory bowel disease: a single Chinese center's experience
    Qiang Wu, Xuehong Wang, Feng Wu, Dehong Peng, Guotao Wu, Lichao Yang, Lianwen Yuan
    BioScience Trends.2021; 15(3): 171.     CrossRef
  • MANAGEMENT OF ILEOCECAL CROHN’S DISEASE DURING SURGICAL TREATMENT FOR ACUTE APPENDICITIS: A SYSTEMATIC REVIEW
    Abel Botelho QUARESMA, Eron Fabio MIRANDA, Paulo Gustavo KOTZE
    Arquivos de Gastroenterologia.2021; 58(4): 560.     CrossRef
  • Risk factors and long-term outcome of disease extent progression in Asian patients with ulcerative colitis: a retrospective cohort study
    Yun Qiu, Baili Chen, Yufei Li, Shanshan Xiong, Shenghong Zhang, Yao He, Zhirong Zeng, Shomron Ben-Horin, Minhu Chen, Ren Mao
    BMC Gastroenterology.2019;[Epub]     CrossRef
  • Initial medical and surgical management of inflammatory bowel disease in the biologic era: A comparison between the United States and China
    Sanskriti Varma, Jun Hu, Ambar Mehta, Yiran Song, Angela Park, Min Zhi, Susan Hutfless
    JGH Open.2019; 3(3): 234.     CrossRef
  • Can molecular stratification improve the treatment of inflammatory bowel disease?
    Claire Wang, Hannah M. Baer, Daniel R. Gaya, Robert J.B. Nibbs, Simon Milling
    Pharmacological Research.2019; 148: 104442.     CrossRef
  • Intrarectally administered polaprezinc attenuates the development of dextran sodium sulfate‑induced ulcerative colitis in mice
    Zhaoyang Liu, Wenbo Xie, Mingru Li, Jing Liu, Xiao Liang, Tao Li
    Experimental and Therapeutic Medicine.2019;[Epub]     CrossRef
  • Changing treatment paradigms for the management of inflammatory bowel disease
    Jong Pil Im, Byong Duk Ye, You Sun Kim, Joo Sung Kim
    The Korean Journal of Internal Medicine.2018; 33(1): 28.     CrossRef
  • Is Adsorptive Granulocyte and Monocyte Apheresis Effective as an Alternative Treatment Option in Patients with Ulcerative Colitis?
    Seong Ran Jeon
    Gut and Liver.2017; 11(2): 171.     CrossRef
  • 5,955 View
  • 75 Download
  • 12 Web of Science
  • 12 Crossref
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