Intestinal Research

Case Report

Drug-induced eosinophilic pneumonia in a patient with Crohn's disease: diagnosis and treatment using fraction of exhaled nitric oxide: Jina Yeo, Hyun Sun Woo, Sang Min Lee, Yoon Jae Kim, Kwang An Kwon, Dong Kyun Park, Jung Ho Kim, Kyoung Oh Kim, Jun-Won Chung; Intest Res 2017;15(4):529-534. Published online October 23, 2017; DOI: https://doi.org/10.5217/ir.2017.15.4.529

Oral 5-aminosalicylic acid agents (mesalazine and sulfasalazine) and azathioprine are the mainstays of treatment for inflammatory bowel disease. Reports of pulmonary toxicity induced by oral 5-aminosalicylic acid agents or azathioprine in patients with inflammatory bowel disease are very rare; to date, only 38 cases have been reported worldwide. We, herein, report a case involving a 26-year-old man who was diagnosed with eosinophilic pneumonia after using mesalazine and azathioprine for the treatment of Crohn's disease and recovered after treatment. We also found that the fraction of exhaled nitric oxide level was elevated in this patient. After treatment, the fraction of exhaled nitric oxide level decreased and the symptoms improved. The present case shows that fraction of exhaled nitric oxide is related to the disease activity and treatment effectiveness of druginduced eosinophilic pneumonia.

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World Journal of Gastroenterology.2020; 26(5): 478. CrossRef
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Oxidative Stress and Effect of Treatment on the Oxidation Product Decomposition Processes in IBD
Ewa Dudzińska, Magdalena Gryzinska, Katarzyna Ognik, Paulina Gil-Kulik, Janusz Kocki, Vladimir Jakovljevic
Oxidative Medicine and Cellular Longevity.2018;[Epub] CrossRef

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Original Articles

Old Age at Diagnosis Is Associated With Favorable Outcomes in Korean Patients With Inflammatory Bowel Disease: Jae Hyuk Choi, Eun Soo Kim, Kwang Bum Cho, Kyung Sik Park, Yoo Jin Lee, Sang Min Lee, Yu Jin Kang, Byung Ik Jang, Kyeong Ok Kim; Intest Res 2015;13(1):60-67. Published online January 29, 2015; DOI: https://doi.org/10.5217/ir.2015.13.1.60

Abstract PDF PubReader

Background/Aims

Despite the rising incidence and prevalence of inflammatory bowel disease (IBD) in Asian populations, data regarding clinical characteristics of patients in Asia based on age at diagnosis are relatively sparse. The aim of this study was to compare clinical characteristics based on the age at diagnosis according to the Montreal Classification in Korean IBD patients.

Methods

We recruited consecutive patients with IBD at two tertiary hospitals and retrospectively reviewed their medical information. Patients were divided into three groups according to their age at diagnosis: youth (<17 years), young adult (17-40 years), and middle-old (>40 years). The main clinical characteristics for comparison were the achievement of a remission state at the last follow-up visit, cumulative rate of surgery, and cumulative use of immunomodulators and tumor necrosis factor-α (TNFα) blockers during the follow-up period.

Results

In total, 346 IBD patients were included (Crohn's disease [CD] 146 and ulcerative colitis 200; 36 youth, 202 young adult, and 113 middle-old). The middle-old group with CD was characterized by a predominance of uncomplicated behavior (P=0.013) and a lower frequency of perianal disease (P=0.009). The middle-old group was associated more with a less aggressive disease course than the younger group, as shown by more frequent remission (P=0.004), being less likely to undergo surgery (P<0.001), and lower cumulative use of immunomodulators and TNFα blockers (P<0.001).

Conclusions

Age at diagnosis according to the Montreal Classification is an important prognostic factor for Korean IBD patients.

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Suk-Kyun Yang
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Impact of age at diagnosis on long‐term prognosis in patients with intestinal Behçet's disease
Ji Young Chang, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Hee Cheon, Jihye Park
Journal of Gastroenterology and Hepatology.2024; 39(3): 519. CrossRef
Peripheral blood neutrophil-to-lymphocyte ratio in inflammatory bowel disease and disease activity: A meta-analysis
Wei Fu, Hu Fu, Weixia Ye, Yinsuo Han, Xianqiang Liu, Sirui Zhu, Hongmin Li, Rong Tang, Qin Wang
International Immunopharmacology.2021; 101: 108235. CrossRef
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Hinaben Panchal, Mathilde Wagner, Manjil Chatterji, Bachir Taouli, Russell McBride, Jeromy R. Patterson, Ryan Ungaro, Marla Dubinsky, Judy Cho, David B. Sachar
Digestive Diseases and Sciences.2019; 64(11): 3274. CrossRef
Characteristics and management of patients with inflammatory bowel disease between a secondary and tertiary hospitals: a propensity score analysis
Ki Hwan Song, Eun Soo Kim, Yoo Jin Lee, Byung Ik Jang, Kyeong Ok Kim, Sang Gyu Kwak, Hyun Seok Lee
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Risk Factors for Vitamin D, Zinc, and Selenium Deficiencies in Korean Patients with Inflammatory Bowel Disease
Yoo Min Han, Hyuk Yoon, Soo Lim, Mi-Kyung Sung, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Joo Sung Kim
Gut and Liver.2017; 11(3): 363. CrossRef
Sampling Strategies for Three-Dimensional Spatial Community Structures in IBD Microbiota Research
Shaocun Zhang, Xiaocang Cao, He Huang
Frontiers in Cellular and Infection Microbiology.2017;[Epub] CrossRef
Influence of age at diagnosis on the clinical characteristics of Crohn's disease in Korea: Results from the CONNECT study
Sung Wook Hwang, Jee Hyun Kim, Jong Pil Im, Byong Duk Ye, Hoon Sup Koo, Kyu Chan Huh, Jae Hee Cheon, You Sun Kim, Young Ho Kim, Dong Soo Han, Won Ho Kim, Joo Sung Kim
Journal of Gastroenterology and Hepatology.2017; 32(10): 1716. CrossRef
Impact of inflammatory bowel disease on daily life: an online survey by the Korean Association for the Study of Intestinal Diseases
Young Sun Kim, Sung-Ae Jung, Kang-Moon Lee, Soo Jung Park, Tae Oh Kim, Chang Hwan Choi, Hyun Gun Kim, Won Moon, Chang Mo Moon, Hye Kyoung Song, Soo-Young Na, Suk-Kyun Yang
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Yoon Jee Lee, Jae Hee Cheon, Jae Hyun Kim, SunHo Yoo, Hyun Jung Lee, Soo Jung Park, Sung Pil Hong, Tae Il Kim, Won Ho Kim
Yonsei Medical Journal.2017; 58(1): 144. CrossRef
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Solvey Schüle, Jean‐Benoît Rossel, Diana Frey, Luc Biedermann, Michael Scharl, Jonas Zeitz, Natália Freitas‐Queiroz, Valérie Pittet, Stephan R Vavricka, Gerhard Rogler, Benjamin Misselwitz
United European Gastroenterology Journal.2016; 4(5): 669. CrossRef
Effect of mucosal healing (Mayo 0) on clinical relapse in patients with ulcerative colitis in clinical remission
Jae Hyun Kim, Jae Hee Cheon, Yehyun Park, Hyun Jung Lee, Soo Jung Park, Tae Il Kim, Won Ho Kim
Scandinavian Journal of Gastroenterology.2016; 51(9): 1069. CrossRef
Patients with perianal Crohn's disease have poor disease outcomes after primary bowel resection
Yoo Min Han, Ji Won Kim, Seong‐Joon Koh, Byeong Gwan Kim, Kook Lae Lee, Jong Pil Im, Joo Sung Kim, Hyun Chae Jung
Journal of Gastroenterology and Hepatology.2016; 31(8): 1436. CrossRef
Clinical features of Crohn's disease in Korean patients residing in Busan and Gyeongnam
Eun Ji Lee, Tae Oh Kim, Geun Am Song, Jong hun Lee, Hyung Wook Kim, Sam Ryong Jee, Seun Ja Park, Hyun Jin Kim, Jong Ha Park
Intestinal Research.2016; 14(1): 30. CrossRef
The Positive Influences of Increasing Age at Diagnosis of Inflammatory Bowel Disease on Disease Prognostication in Asian Perspective
Raja Affendi Raja Ali
Intestinal Research.2015; 13(1): 4. CrossRef
Continuous duodenal levodopa infusion in a patient with Crohn's disease and small bowel surgery — Case report
Svetlana Tomic, Danijela Skelac, Dario Mick, Ivan Segec, Bojan Resan, Silva Butkovic Soldo
Journal of the Neurological Sciences.2015; 358(1-2): 525. CrossRef

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Is the Environment of the Endoscopy Unit a Reservoir of Pathogens?: Eun Sung Choi, Jae Hyuk Choi, Jung Min Lee, Sang Min Lee, Yoo Jin Lee, Yu Jin Kang, Eun Soo Kim, Kwang Bum Cho, Kyung Sik Park, Byoung Kuk Jang, Jae Seok Hwang, Woo Jin Chung, Nam Hee Ryoo, Seong Woo Jeon, Min Kyu Jung; Intest Res 2014;12(4):306-312. Published online October 27, 2014; DOI: https://doi.org/10.5217/ir.2014.12.4.306

Abstract PDF PubReader ePub

Background/Aims

Given the characteristic procedures involved in the endoscopy unit, the spread of pathogens is much more frequent in this unit than in other environments. However, there is a lack of data elucidating the existence of pathogens in the endoscopy unit. The aim of this study was to detect the presence of possible pathogens in the endoscopy unit.

Methods

We performed environmental culture using samples from the endoscopy rooms of 2 tertiary hospitals. We used sterile cotton-tipped swabs moistened with sterile saline to swab the surfaces of 197 samples. Then, we cultured the swab in blood agar plate. Samples from the colonoscopy room were placed in thioglycollate broth to detect the presence of anaerobes. After 2 weeks of culture period, we counted the colony numbers.

Results

The most commonly contaminated spots were the doctor's keyboard, nurse's cart, and nurse's mouse. The common organisms found were non-pathogenic bacterial microorganisms Staphylococcus, Micrococcus, and Streptococcus spp.. No definite anaerobe organism was detected in the colonoscopy room.

Conclusions

Although the organisms detected in the endoscopy unit were mainly non-pathogenic organisms, they might cause opportunistic infections in immunocompromised patients. Therefore, the environment of the endoscopy room should be managed appropriately; moreover, individual hand hygiene is important for preventing possible hospital-acquired infections.

Citations

Citations to this article as recorded by

Speech Recognition System Generates Highly Accurate Endoscopic Reports in Clinical Practice
Hiroshi Takayama, Toshitatsu Takao, Ryo Masumura, Yoshikazu Yamaguchi, Ryo Yonezawa, Hiroya Sakaguchi, Yoshinori Morita, Takashi Toyonaga, Kazutaka Izumiyama, Yuzo Kodama
Internal Medicine.2023; 62(2): 153. CrossRef
What’s on your keyboard? A systematic review of the contamination of peripheral computer devices in healthcare settings
Nicole Ide, Bianca K Frogner, Cynthia M LeRouge, Patrick Vigil, Matthew Thompson
BMJ Open.2019; 9(3): e026437. CrossRef
Addressing Bacterial Surface Contamination in Radiology Work Spaces
Alexander Harvin, Kyle VanMiddlesworth, Jonathan Botstein, Robert Hazelrigg, Jeanne Hill, Paul Thacker
Journal of the American College of Radiology.2016; 13(10): 1271. CrossRef

9,445 View
51 Download
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