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Original Articles
Long-Term Clinical Outcomes of Korean Patient With Crohn's Disease Following Early Use of Infliximab
Nam Hee Kim, Yoon Suk Jung, Chang Mo Moon, Shin Yeong Lee, Eun Ran Kim, Young Ho Kim, Chang Kyun Lee, Suck Ho Lee, Jae Hak Kim, Kyu Chan Huh, Soon Man Yoon, Hyun Joo Song, Sun-Jin Boo, Hyun Joo Jang, You Sun Kim, Kang-Moon Lee, Jeong Eun Shin, Dong Il Park
Intest Res 2014;12(4):281-286.   Published online October 27, 2014
DOI: https://doi.org/10.5217/ir.2014.12.4.281
AbstractAbstract PDFPubReaderePub
<b>Background/Aims</b><br/>

Several recent studies have reported that the early use of infliximab (IFX) improves the prognosis of Crohn's disease (CD). However, no data are available from Asian populations, as the forementioned studies have all been conducted in Western countries. The aim of the current study was to evaluate the impact of early use of IFX on the prognosis of Korean patients with CD.

Methods

Patients with a diagnosis of CD established between July 1987 and January 2012 were investigated in 12 university hospitals in Korea. Because insurance coverage for IFX treatment began in August 2005, patients were assigned to either of 2 groups based on diagnosis date. The first group included patients diagnosed from July 1987 to December 2005, and the second from January 2006 to January 2012. We compared the cumulative probabilities of operation and reoperation between the two groups using the Kaplan-Meier method and a log-rank test.

Results

Of the 721 patients investigated, 443 (61.4%) comprized the second group. Although the cumulative probabilities of immunosuppressant (P<0.001) and IFX use (P<0.001) after diagnosis were significantly higher in the second group, there were no significant differences in cumulative probabilities of operation (P=0.905) or reoperation (P=0.418) between two groups.

Conclusions

The early use of IFX did not reduce CD-related surgery requirements in Korean patients with CD. These study results suggest that the early use of IFX may have little impact on the clinical outcome of CD in Korean patients in the setting of a conventional step-up algorithm.

Citations

Citations to this article as recorded by  
  • The Potential of Molecular Remission: Tissue Neutrophil Elastase Is Better Than Histological Activity for Predicting Long-Term Relapse in Patients With Ulcerative Colitis in Endoscopic Remission
    Yu Kyung Jun, Hyeon Jeong Oh, Ji Ae Lee, Yonghoon Choi, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Hyuk Yoon
    Inflammatory Bowel Diseases.2025; 31(2): 514.     CrossRef
  • Differences in the risk of clinical failure between thiopurine and methotrexate in bio-naïve patients with Crohn’s disease: a Korean nationwide population-based study
    Yu Kyung Jun, Eunjeong Ji, Hye Ran Yang, Yonghoon Choi, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Hyuk Yoon
    Therapeutic Advances in Gastroenterology.2024;[Epub]     CrossRef
  • Efficacy of COVID-19 vaccines in inflammatory bowel disease patients receiving anti-TNF therapy: A systematic review and meta-analysis
    Dan Dou, Fangyi Zhang, Xin Deng, Yun Ma, Shuqing Wang, Xingyu Ji, Xihan Zhu, Dianpeng Wang, Shengsheng Zhang, Luqing Zhao
    Heliyon.2023; 9(9): e19609.     CrossRef
  • Pharmacodynamic mechanisms behind a refractory state in inflammatory bowel disease
    Rasmus Goll, Øystein K. Moe, Kay-Martin Johnsen, Renate Meyer, Joachim Friestad, Mona D. Gundersen, Hege Kileng, Knut Johnsen, Jon R. Florholmen
    BMC Gastroenterology.2022;[Epub]     CrossRef
  • Editorial: does anti‐TNF “treatment persistence” always equate to “effective treatment”? Only objective disease assessments can answer the question
    Ashish Srinivasan, Daniel R. van Langenberg
    Alimentary Pharmacology & Therapeutics.2021; 54(5): 718.     CrossRef
  • Blocking tumor necrosis factor paved the way for targeted therapeutics in inflammatory diseases
    Cong-Qiu Chu
    Chinese Medical Journal.2021; 134(21): 2525.     CrossRef
  • A State-of-the-Art Review of New and Emerging Therapies for the Treatment of IBD
    Kenechukwu O Chudy-Onwugaje, Kaci E Christian, Francis A Farraye, Raymond K Cross
    Inflammatory Bowel Diseases.2019; 25(5): 820.     CrossRef
  • Efficacy of Anti-TNF Therapy for the Treatment of Patients with Moderate-to-Severe Inflammatory Bowel Disease; a First Iranian Report
    Samaneh Mohagheghi Darehranj, Sudabeh Alatab, Homayoon Vahedi, Anahita Sadeghi, Alireza Sima, Masoud Malekzadeh, Amir Anoshiravani, Hafez Fakheri, Nasser Ebrahimi Daryani, Abdolhamid Mousavi, Fariborz Mansour-Ghanaei, Mohammad Javad Zahedi, Reza Malekzade
    Middle East Journal of Digestive Diseases.2019; 12(1): 12.     CrossRef
  • Novel treatments for inflammatory bowel disease
    Hyo Sun Lee, Soo-Kyung Park, Dong Il Park
    The Korean Journal of Internal Medicine.2018; 33(1): 20.     CrossRef
  • Association of Perianal Fistulas with Clinical Features and Prognosis of Crohn's Disease in Korea: Results from the CONNECT Study
    Jaeyoung Chun, Jong Pil Im, Ji Won Kim, Kook Lae Lee, Chang Hwan Choi, Hyunsoo Kim, Jae Hee Cheon, Byong Duk Ye, Young-Ho Kim, You Sun Kim, Yoon Tae Jeen, Dong Soo Han, Won Ho Kim, Joo Sung Kim
    Gut and Liver.2018; 12(5): 544.     CrossRef
  • Physicians Should Provide Shared Decision-Making for Anti-TNF Therapy to Inflammatory Bowel Disease Patients
    Jae Myung Cha, Dong Il Park, Sang Hyoung Park, Jeong Eun Shin, Wan Soo Kim, Suk-Kyun Yang
    Journal of Korean Medical Science.2017; 32(1): 85.     CrossRef
  • Fecal microbiota transplantation for refractory Crohn's disease
    Seon Ho Bak, Hyun Ho Choi, Jinhee Lee, Mi Hee Kim, Youn Hee Lee, Jin Su Kim, Young-Seok Cho
    Intestinal Research.2017; 15(2): 244.     CrossRef
  • Long-Term Outcomes of Infliximab Treatment in 582 Korean Patients with Crohn’s Disease: A Hospital-Based Cohort Study
    Sang Hyoung Park, Sung Wook Hwang, Min Seob Kwak, Wan Soo Kim, Jeong-Mi Lee, Ho-Su Lee, Dong-Hoon Yang, Kyung-Jo Kim, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Yong Sik Yoon, Chang Sik Yu, Jin-Ho Kim, Suk-Kyun Yang
    Digestive Diseases and Sciences.2016; 61(7): 2060.     CrossRef
  • Factors Contributing to the Preference of Korean Patients with Crohn's Disease When Selecting an Anti-Tumor Necrosis Factor Agent (CHOICE Study)
    Eun Soo Kim, Kyeong Ok Kim, Byung Ik Jang, Chang Kyun Lee, Hyo Jong Kim, Kang-Moon Lee, You Sun Kim, Chang Soo Eun, Sung-Ae Jung, Suk-Kyun Yang, Jun Lee, Tae-Oh Kim, Yunho Jung, Geom Seog Seo, Soon Man Yoon
    Gut and Liver.2016;[Epub]     CrossRef
  • The Efficiency of Intravenous Iron Therapy in Korean Inflammatory Bowel Disease Patients
    Kyeong Ok Kim
    Gut and Liver.2016; 10(4): 487.     CrossRef
  • Clinical features of Crohn's disease in Korean patients residing in Busan and Gyeongnam
    Eun Ji Lee, Tae Oh Kim, Geun Am Song, Jong hun Lee, Hyung Wook Kim, Sam Ryong Jee, Seun Ja Park, Hyun Jin Kim, Jong Ha Park
    Intestinal Research.2016; 14(1): 30.     CrossRef
  • Advanced age impacts surgical characteristics and postoperative course in patients with Crohn's disease
    Stanislaus Argeny, Anton Stift, Martina Mittlböck, Amy C. Lord, Svenja Maschke, Mathias Schneeweiß, Stefan Riss
    International Journal of Surgery.2016; 33: 182.     CrossRef
  • The clinical usefulness of a web-based messaging system between patients with Crohn disease and their physicians
    Da Eun Jeong, Kyeong Ok Kim, Byung Ik Jang, Eun Young Kim, Jin Tae Jung, Seong Woo Jeon, Hyun Seok Lee, Eun Soo Kim, Kyung Sik Park, Kwang Bum Cho
    Medicine.2016; 95(26): e4028.     CrossRef
  • The clinical characteristics of patients with free perforation in Korean Crohn’s disease: results from the CONNECT study
    Young Seok Doh, You Sun Kim, Song I Bae, Jong Pil Im, Jae Hee Cheon, Byong Duk Ye, Ji Won Kim, Young Sook Park, Ji Hyun Lee, Young-Ho Kim, Joo Sung Kim, Dong Soo Han, Won Ho Kim
    BMC Gastroenterology.2015;[Epub]     CrossRef
  • Management of Anemia in Patients with Inflammatory Bowel Disease
    Kyeong Ok Kim
    The Korean Journal of Gastroenterology.2015; 65(3): 145.     CrossRef
  • Could Early Anti-Tumor Necrosis Factor Therapy Change the Prognosis of Crohn's Disease?
    Byong Duk Ye
    Intestinal Research.2014; 12(4): 263.     CrossRef
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  • 20 Web of Science
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Prevalence, Clinicopathologic Characteristics, and Predictors of Interval Colorectal Cancers in Korean Population
Chang Joon Kim, Yoon Suk Jung, Jung Ho Park, Hong Joo Kim, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Shin Yeong Lee, Hwa Mok Kim, Ki Bae Bang, Dae Sung Lee, Dong Il Park
Intest Res 2013;11(3):178-183.   Published online July 30, 2013
DOI: https://doi.org/10.5217/ir.2013.11.3.178
AbstractAbstract PDF
Background/Aims
A subset of patients may develop colorectal cancer after a colonoscopy that was negative for carcinoma. These missed or de novo developed lesions were termed as interval cancers. Many studies regarding interval cancer have been conducted in Western countries, whereas very limited data are available in Asian populations. Therefore, the purpose of this study was to investigate prevalence, clinicopathologic features, and predictors of interval colorectal cancers in the Korean population. Methods: Interval cancer was defined as a cancer that is diagnosed within 5 years of a negative colonoscopy result. Among the patients who were diagnosed colorectal cancers at Kangbuk Samsung Hospital from January 2007 to April 2012, clinicopathologic characteristics of interval cancers were compared with those of sporadic cancers. Results: Among the 785 patients, 482 responded to telephone calls. Of these, 30 (6.2%) developed interval cancers. Finally, 28 patients who had interval cancers were compared with 415 patients who had sporadic cancers. Interval cancer group was significantly younger and more frequent in the right side colon than sporadic cancer group. There was no differences in sex, tumor size, differentiation, and staging between two groups. In multivariate analysis, young age and right side colon cancer were independent factors associated with an interval cancer. Conclusions: A significant proportion of Korean patients developed interval colorectal cancer, especially at the young age and in the proximal colon. (Intest Res 2013;11:178-183)

Citations

Citations to this article as recorded by  
  • Post-colonoscopy Colorectal Cancer: Causes and Prevention
    Jong Yoon Lee
    Journal of Digestive Cancer Research.2024; 12(3): 160.     CrossRef
  • Clinical and endoscopic characteristics of sessile serrated lesions with dysplasia/carcinoma
    Peel Jung, Hyung Wook Kim, Su Bum Park, Dae Hwan Kang, Cheol Woong Choi, Su Jin Kim, Hyeong Seok Nam, Dae Gon Ryu, Dong Hoon Shin, Joo Young Na, Mi Sook Yun
    The Korean Journal of Internal Medicine.2023; 38(3): 349.     CrossRef
  • Post-colonoscopy Colorectal Cancer: Causes and Prevention of Interval Colorectal Cancer
    Jong Yoon Lee, Jong Hoon Lee
    The Korean Journal of Gastroenterology.2020; 75(6): 314.     CrossRef
  • Frequency and Characteristics of Interval Colorectal Cancer in Actual Clinical Practice: A KASID Multicenter Study
    Kyeong Ok Kim, Kyu Chan Huh, Sung Pil Hong, Won Hee Kim, Hyuk Yoon, Sang Wook Kim, Yeon Soo Kim, Jong Ha Park, Jun Lee, Bum Jae Lee, Young Sook Park
    Gut and Liver.2018; 12(5): 537.     CrossRef
  • Molecular Imaging of Colorectal Tumors by Targeting Colon Cancer Secreted Protein-2 (CCSP-2)
    Jaeil Kim, Eun-ju Do, Helen Moinova, Sang Mun Bae, Ja Young Kang, Seung-Mo Hong, Stephen P. Fink, Jinmyoung Joo, Young-Ah Suh, Se Jin Jang, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Jaewon Choe, Suk-Kyun Yang, Sanfo
    Neoplasia.2017; 19(10): 805.     CrossRef
  • External Validation of the Endoscopic Features of Sessile Serrated Adenomas in Expert and Trainee Colonoscopists
    Hyo-Joon Yang, Jeong In Lee, Soo-Kyung Park, Yoon Suk Jung, Jin Hee Sohn, Kyu Yong Choi, Dong Il Park
    Clinical Endoscopy.2017; 50(3): 279.     CrossRef
  • Comparative Study on Bowel Preparation Efficacy of Ascorbic Acid Containing Polyethylene Glycol by Adding Either Simethicone or 1 L of Water in Health Medical Examination Patients: A Prospective Randomized Controlled Study
    Se Hwan Yeo, Jae Hoon Kwak, Yeo Un Kim, Tae Ho Kwon, Jeong Bae Park, Jun Hyung Park, Yong Kook Lee, Yun Jeong Lim, Chang Heon Yang
    The Korean Journal of Gastroenterology.2016; 67(4): 189.     CrossRef
  • Microsatellite Instability Status of Interval Colorectal Cancers in a Korean Population
    Kil Woo Lee, Soo-Kyung Park, Hyo-Joon Yang, Yoon Suk Jung, Kyu Yong Choi, Kyung Eun Kim, Kyung Uk Jung, Hyung Ook Kim, Hungdai Kim, Ho-Kyung Chun, Dong Il Park
    Gut and Liver.2016; 10(5): 781.     CrossRef
  • Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population
    Seung Eun Lee, Hee Bum Jo, Won Gun Kwack, Yun Jin Jeong, Yeo-Jin Yoon, Hyoun Woo Kang
    World Journal of Gastroenterology.2016; 22(10): 2981.     CrossRef
  • Randomized Controlled Trial of Sodium Phosphate Tablets versus 2 L Polyethylene Glycol Solution for Bowel Cleansing prior to Colonoscopy
    Yun Ho Lee, Seong Yeon Jeong, You Sun Kim, Hye Jin Jung, Min Jung Kwon, Cheol Hun Kwak, Song I Bae, Jeong Seop Moon, Ji Won Kim, Su Hwan Kim, Kook Lae Lee
    The Korean Journal of Gastroenterology.2015; 65(1): 27.     CrossRef
  • The Risk of Metachronous Advanced Colorectal Neoplasia Rises in Parallel with an Increasing Number of High-Risk Findings at Baseline
    Seung Min Lee, Jeong Hwan Kim, In Kyung Sung, Sung Noh Hong
    Gut and Liver.2015; 9(6): 741.     CrossRef
  • Rapidly Growing Interval Colon Cancer
    Jae Hyun Kim, Moo In Park
    The Korean Journal of Gastroenterology.2015; 65(5): 326.     CrossRef
  • Colonoscopy Quality is the Answer for the Emerging Issue of Interval Cancer
    Jae Myung Cha
    Intestinal Research.2014; 12(2): 110.     CrossRef
  • Interval Cancers after a Negative Colonoscopy Finding in a Korean Population: A Small Step for Gastroenterologists but One Giant Leap for Koreans
    Jae Myung Cha
    Intestinal Research.2014; 12(2): 169.     CrossRef
  • Author's Reply
    Dong Il Park
    Intestinal Research.2014; 12(2): 171.     CrossRef
  • Development and Predictor of Interval Colorectal Cancer
    Tae-Oh Kim
    Intestinal Research.2013; 11(3): 153.     CrossRef
  • What Matters in Colonoscopy?
    Hyun Shig Kim
    Annals of Coloproctology.2013; 29(6): 223.     CrossRef
  • 3,216 View
  • 50 Download
  • 17 Crossref
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