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2 "Shinji Tanaka"
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Original Article
Inflammatory Bowel Diseases
Clinical characteristics of inflammatory bowel disease patients with immunoglobulin A nephropathy
Ryohei Hayashi, Yoshitaka Ueno, Shinji Tanaka, Kana Onishi, Takeshi Takasago, Masaki Wakai, Toshikatsu Naito, Kensuke Sasaki, Shigehiro Doi, Takao Masaki, Kazuaki Chayama
Intest Res 2021;19(4):430-437.   Published online November 9, 2020
DOI: https://doi.org/10.5217/ir.2020.00067
AbstractAbstract PDFPubReaderePub
Background/Aims
Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract. Some patients with this condition have been reported to present with immunoglobulin A nephropathy (IgAN), a renal complication that can cause end-stage renal failure, but the frequency of this comorbidity has not been described. Thus, the aim of this study was to investigate the frequency of IgAN in patients with IBD.
Methods
This study included 620 patients with IBD (338 with ulcerative colitis [UC] and 282 with Crohn’s disease [CD]) from the Hiroshima University Hospital outpatient department. IgAN cases were identified from medical interviews, blood examinations (serum immunoglobulin A), and urinalyses (occult blood, proteinuria). Definitive IgAN cases were diagnosed by renal biopsies, while those detected through the clinical course and test results, but not clinically recommended for renal biopsy, were defined as suspected IgAN.
Results
We analyzed 427 cases meeting the inclusion criteria (220 with UC and 207 with CD). The incidence of IgAN across all patients with IBD was 3.0%. The frequency of IgAN was significantly higher in patients with CD (11/207, 5.3%) than in those with UC (2/220, 0.9%) (P< 0.01). Moreover, a significant correlation was found between CD patients with ileostomy or colostomy and a diagnosis of IgAN.
Conclusions
Patients with IBD present a high incidence of IgAN, especially those with CD who have undergone ileostomy or colostomy.

Citations

Citations to this article as recorded by  
  • Infliximab may contribute to remit rapidly progressive of IgA nephropathy secondary to Crohn's disease: A case report
    Songyan Wan, Han Chen, Siqi Liu, Zhenliang Fan, Junfen Fan
    Technology and Health Care.2025;[Epub]     CrossRef
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    World Journal of Nephrology.2024;[Epub]     CrossRef
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    Frontiers in Immunology.2022;[Epub]     CrossRef
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Brief Communication
IBD
Effect of elemental diet combined with infliximab dose escalation in patients with Crohn's disease with loss of response to infliximab: CERISIER trial
Tadakazu Hisamatsu, Reiko Kunisaki, Shiro Nakamura, Tomoyuki Tsujikawa, Fumihito Hirai, Hiroshi Nakase, Kenji Watanabe, Kaoru Yokoyama, Masakazu Nagahori, Takanori Kanai, Makoto Naganuma, Hirofumi Michimae, Akira Andoh, Akihiro Yamada, Tadashi Yokoyama, Noriko Kamata, Shinji Tanaka, Yasuo Suzuki, Toshifumi Hibi, Mamoru Watanabe
Intest Res 2018;16(3):494-498.   Published online July 27, 2018
DOI: https://doi.org/10.5217/ir.2018.16.3.494
PDFSupplementary MaterialPubReaderePub

Citations

Citations to this article as recorded by  
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    Journal of Crohn's and Colitis.2025;[Epub]     CrossRef
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    Fleur T. R. Wijers, Suzanne M. C. van Zundert, Charlotte M. Verburgt, Nikki van der Kruk, Johan E. Van Limbergen, Nicolette J. Wierdsma
    Therapeutic Advances in Gastroenterology.2025;[Epub]     CrossRef
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    Konstantinos Gerasimidis
    Clinical Nutrition ESPEN.2025; 67: 233.     CrossRef
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    United European Gastroenterology Journal.2025;[Epub]     CrossRef
  • Prospective study of an adalimumab combined with partial enteral nutrition in the induction period of Crohn’s disease
    Sisi Zhou, Zeyu Huang, Wenjing Hou, Yiting Lin, Jing Yu
    Inflammation Research.2024; 73(2): 199.     CrossRef
  • Role of diet in prevention versus treatment of Crohn’s disease and ulcerative colitis
    Emma P Halmos, Lihi Godny, Julie Vanderstappen, Chen Sarbagili-Shabat, Vaios Svolos
    Frontline Gastroenterology.2024; : flgastro-2023-102417.     CrossRef
  • Immunoregulatory Effects of Elemental Diet and Its Ingredient, Tryptophan, via Activation of the Aryl Hydrocarbon Receptor in Mice
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  • Nutritional Therapy Strategies in Pediatric Crohn’s Disease
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  • Evidence-based clinical practice guidelines for inflammatory bowel disease 2020
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  • 7,699 View
  • 158 Download
  • 22 Web of Science
  • 23 Crossref
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