Intestinal Research

Original Articles

Burden of inflammatory bowel disease in India: analysis of the Global Burden of Disease study from 1990 to 2019: Suprabhat Giri, Anuraag Jena, Praveen Kumar-M, Jaikumar Rajavoor Muniswamy, Preetam Nath, Vishal Sharma; Received August 26, 2024 Accepted December 4, 2024 Published online February 6, 2025; DOI: https://doi.org/10.5217/ir.2024.00134 [Epub ahead of print]

Background/Aims
Inflammatory bowel disease (IBD) is increasing across the globe, more so in populous countries like India. We aimed to study the disease burden and epidemiological trends of IBD in India and look closer into the disease pattern across the country from 1990 to 2019.
Methods
The burden of IBD was estimated in India using the data from the Global Burden of Disease estimate for 2019, which is a comprehensive worldwide project. The analysis included various parameters like incidence, prevalence, mortality, disability-adjusted life years, years lived with disability, and years of life lost as age-adjusted rates (per 100,000 population). Using modeling, the prediction was also made for 2050 in India.
Results
The age-standardized incidence, prevalence, mortality, and disability rates of IBD in India for 2019 were 2.34, 20.34, 0.40, and 13.04, respectively. These are lower than the global incidence, prevalence, mortality, and disability rates of 4.97, 59.25, 0.54, and 20.15, respectively. The annual rates of change in incidence, prevalence, mortality, and disability rates in India from 1990 to 2019 were 0.05, –0.02, –0.36, and –0.35, respectively. The annual rates of change in incidence and prevalence are higher than the global rate of –0.18 and –0.19, while the annual rates of change in mortality and disability are lower than the global rate of –0.19 and –0.26.
Conclusions
The incidence and prevalence of IBD in India are lower compared to the global population but are increasing at a faster rate than the global population.

Citations

Citations to this article as recorded by

Impact of GLP-1 analogues on immune-mediated inflammatory diseases: A systematic review
Chhagan L. Birda, Fadwa Ibrahim, Abhirup Chatterjee, Anuraag Jena, Vishal Sharma, Shaji Sebastian
Autoimmunity Reviews.2026; 25(1): 103936. CrossRef
Burden of anemia in inflammatory bowel disease: A systematic review and meta-analysis
Rupa Tharu, Savitesh Kushwaha, Rachana Srivastava, Vaneet Jearth, Nitin Kaushal, Anupam Kumar Singh, Shweta Khandelwal, Poonam Khanna
Clinical Epidemiology and Global Health.2026; 37: 102262. CrossRef
Modulation of colonic DNA methyltransferase by mild moxibustion and electroacupuncture in ulcerative colitis TET2 knockout mice
Gege Feng, Yue Zhang, Huangan Wu, Lu Zhu, Hongxiao Xu, Zhe Ma, Yan Huang
Digital Chinese Medicine.2025; 8(1): 100. CrossRef
Research Status of Anemia Associated with Inflammatory Bowel Disease
莉娟孙
Journal of Clinical Personalized Medicine.2025; 04(03): 712. CrossRef
Efficacy of tirzepatide for weight loss and it’s comparative effectiveness to weight loss surgery in inflammatory bowel disease
Aakash Desai, Himsikhar Khataniar, Fjona Tabaku, Jana G. Hashash, Francis A. Farraye, Gursimran S. Kochhar
Indian Journal of Gastroenterology.2025;[Epub] CrossRef
The adoption of a westernized gut microbiome in Indian Immigrants and Indo-Canadians is associated with dietary acculturation
Leah D. D’Aloisio, Mamatha Ballal, Sanjoy Ghosh, Natasha Haskey, Nijiati Abulizi, Ramin Karimianghadim, Chuyi Liu, Pacha Sruthi, Lakshmipriya Nagarajan, Sudha Vasudevan, Vignesh Shetty, Mrudgandha Purandare, Ushasi Bhaumik, Debaki Ranjan Howlader, Sepideh
npj Biofilms and Microbiomes.2025;[Epub] CrossRef
Next-generation non-animal models for inflammatory bowel disease: In vitro and in silico approaches for mechanistic understanding
Priyanka Raju Chougule, Sukesh Narayan Sinha
NAM Journal.2025; 1: 100051. CrossRef
Relation of ultra-processed food consumption with ulcerative colitis disease activity
Nancy Sahni, Ayushi, Urvashi Rana, Radhika Khosla, Usha Dutta, Rakesh Kochhar, Vishal Sharma
Indian Journal of Gastroenterology.2025;[Epub] CrossRef
Modulation of inflammatory and cuproptotic crosstalk by Ethyl and propyl gallate: a multi-targeted strategy against experimental colitis
Priyanka Raju Chougule, Sukesh Narayan Sinha, Sudip Ghosh, Sangaraju Rajendra, Saikanth Varma, Suresh Challa, Manjula Bhanoori
Molecular Biology Reports.2025;[Epub] CrossRef
Stroke in paediatric Crohn’s disease
Sai Anjali Kambala, Seema Pavaman Sindgikar, Daniya Hameed, Chandrashekar J Sorake
BMJ Case Reports.2025; 18(12): e269145. CrossRef
Editorial: The Hidden Burden—Stigmatisation in Inflammatory Bowel Disease: Authors' Reply
Suprabhat Giri, Anuraag Jena, Vishal Sharma, Shaji Sebastian
Alimentary Pharmacology & Therapeutics.2025;[Epub] CrossRef

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IBD

Prevalence of hepatitis B virus and hepatitis C virus infection in patients with inflammatory bowel disease: a systematic review and meta-analysis: Suprabhat Giri, Dhiraj Agrawal, Shivaraj Afzalpurkar, Sunil Kasturi, Amrit Gopan, Sridhar Sundaram, Aditya Kale; Intest Res 2023;21(3):392-405. Published online December 2, 2022; DOI: https://doi.org/10.5217/ir.2022.00094

Abstract PDF Supplementary Material PubReader ePub

Background/Aims
The data on the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in patients with inflammatory bowel disease (IBD) are conflicting. The present systematic review was thus conducted to study the prevalence of HBV and HCV markers in patients with IBD.
Methods
A comprehensive literature search of 3 databases was conducted from 2000 to April 2022 for studies evaluating the prevalence of HBV or HCV in patients with IBD. Pooled prevalence rates across studies were expressed with summative statistics.
Results
A total of 34 studies were included in the final analysis. The pooled prevalence of hepatitis B surface antigen (HBsAg) and hepatitis B core antibodies were 3.3% and 14.2%, respectively. In HBsAg positive IBD patients, hepatitis B e antigen positivity and detectable HBV DNA were seen in 15.3% and 61.0% of patients, respectively. Only 35.6% of the IBD patients had effective HBV vaccination. The pooled prevalence of anti-HCV and detectable HCV RNA were 1.8% and 0.8%, respectively. The pooled prevalence of markers of HBV infection was higher in Asian studies, while the prevalence of markers of HCV infection was higher in European studies. The prevalence of viral hepatitis markers was similar between IBD patients and the general population and that between ulcerative colitis and Crohn’s disease.
Conclusions
The prevalence of markers of viral hepatitis remains same as the general population with significant regional variations, although the quality of evidence remains low due to publication bias. Only a small proportion of IBD patients had an effective HBV vaccination, requiring improvement in screening and vaccination practices.

Citations

Citations to this article as recorded by

Hepatobiliary and pancreatic manifestations in inflammatory bowel disease: an umbrella review of meta-analyses
Runsheng Hong, Zhixue Li, Meng Li, Yun Dai
Therapeutic Advances in Gastroenterology.2025;[Epub] CrossRef
Serological Assessment of Hepatitis in Patients with Inflammatory Bowel Disease in Taiwan: A Retrospective Cohort Analysis
Yueh-An Lee, Hsu-Heng Yen, Yang-Yuan Chen
Life.2025; 15(6): 893. CrossRef
British Society of Gastroenterology guidelines on inflammatory bowel disease in adults: 2025
Gordon W Moran, Morris Gordon, Vassiliki Sinopoulou, Shellie J Radford, Ana-Maria Darie, Sudheer Kumar Vuyyuru, Laith Alrubaiy, Naila Arebi, Jonathan Blackwell, Thomas D Butler, Thean Chew, Michael Colwill, Rachel Cooney, Gabriele De Marco, Said Din, Shah
Gut.2025; 74(Suppl 2): s1. CrossRef
Management of ulcerative colitis in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease updated in 2023
Hsu-Heng Yen, Jia-Feng Wu, Horng-Yuan Wang, Ting-An Chang, Chung-Hsin Chang, Chen-Wang Chang, Te-Hsin Chao, Jen-Wei Chou, Yenn-Hwei Chou, Chiao-Hsiung Chuang, Wen-Hung Hsu, Tzu-Chi Hsu, Tien-Yu Huang, Tsung-I Hung, Puo-Hsien Le, Chun-Che Lin, Chun-Chi Lin
Intestinal Research.2024; 22(3): 213. CrossRef
Assessing the associations of inflammatory bowel disease and hepatitis B virus infections with two-sample bidirectional mendelian randomization
Ping Han, Chaohui Wang, Yan Qiu
Critical Public Health.2024; 34(1): 1. CrossRef
Associations between chronic hepatitis B infection and inflammatory bowel diseases in East Asian populations
Haiyan Ye, Deqin Wei, Yike Huang
Future Virology.2024; 19(16-18): 563. CrossRef
Protective role of flavonoids quercetin and silymarin in the viral-associated inflammatory bowel disease: an updated review
Elham Zarenezhad, Hussein T. Abdulabbas, Ahmed Shayaa Kareem, Seyed Amin Kouhpayeh, Silvia Barbaresi, Sohrab Najafipour, Abdulbaset Mazarzaei, Mitra Sotoudeh, Abdolmajid Ghasemian
Archives of Microbiology.2023;[Epub] CrossRef
Infectious complications in patients with inflammatory bowel disease in Asia: the results of a multinational web-based survey in the 8th Asian Organization for Crohn’s and Colitis meeting
Yu Kyung Jun, Seong-Joon Koh, Dae Seong Myung, Sang Hyoung Park, Choon Jin Ooi, Ajit Sood, Jong Pil Im
Intestinal Research.2023; 21(3): 353. CrossRef
Ulcerative colitis coexisting with hepatitis C: A rare occurrence
Xiaoqiang Liu, Yisen Huan, Yubin Wang, Yingxuan Huang
Medicine.2023; 102(50): e36629. CrossRef

8,076 View
400 Download
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9 Crossref

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