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2 "Tamotsu Sugai"
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Colorectal neoplasia
Microvascular density under magnifying narrow-band imaging endoscopy in colorectal epithelial neoplasms
Takahiro Gonai, Keisuke Kawasaki, Shotaro Nakamura, Shunichi Yanai, Risaburo Akasaka, Kunihiko Sato, Yousuke Toya, Kensuke Asakura, Jun Urushikubo, Yasuko Fujita, Makoto Eizuka, Noriyuki Uesugi, Tamotsu Sugai, Takayuki Matsumoto
Intest Res 2020;18(1):107-114.   Published online November 4, 2019
DOI: https://doi.org/10.5217/ir.2019.00061
AbstractAbstract PDFPubReaderePub
Background/Aims
Magnifying endoscopic classification systems, such as the Japan narrow-band imaging (NBI) Expert Team (JNET) classification, have been widely used for predicting the histologic diagnosis and invasion depth of colorectal epithelial tumors. However, disagreement exists among observers regarding magnifying endoscopic diagnosis, because these classification systems are subjective. We herein investigated the utility of endoscopic microvascular density (eMVD) calculated from magnifying NBI endoscopic images in colorectal tumors.
Methods
We reviewed magnifying NBI endoscopic images from 169 colorectal epithelial tumors (97 adenomas, 72 carcinomas/high-grade dysplasias) resected endoscopically or surgically. The eMVD on magnifying NBI endoscopic images was evaluated using image-editing software, and relationships between eMVD and clinical, endoscopic, and pathological findings were retrospectively analyzed.
Results
The eMVD in carcinomas (0.152 ± 0.079) was significantly higher than that in adenomas (0.119 ± 0.059, P< 0.05). The best cutoff value for distinguishing carcinoma from adenoma was 0.133. Sensitivity, specificity, and accuracy were 56.9%, 67.0%, and 62.7%, respectively. In addition, JNET type 2B tumors showed significantly higher eMVD (0.162 ± 0.079) compared to type 2A tumors (0.111 ± 0.050, P< 0.05).
Conclusions
The eMVD as determined by magnifying NBI endoscopy is considered to be a possible objective indicator for differentiating colorectal carcinomas from adenomas.

Citations

Citations to this article as recorded by  
  • Novel physiological analysis using blood flow velocity for colonic polyps: Pilot study
    Eiji Kamba, Takashi Murakami, Naoki Tsugawa, Kei Nomura, Keiichi Haga, Yoichi Akazawa, Hirofumi Fukushima, Hiroya Ueyama, Kenshi Matsumoto, Tomoyoshi Shibuya, Takeshi Terai, Takashi Yao, Akihito Nagahara
    Endoscopy International Open.2024; 12(06): E781.     CrossRef
  • Feasibility of moxifloxacin and proflavine dual fluorescence imaging for detecting gastrointestinal neoplastic lesions: A prospective study
    Kwangwoo Nam, Noseong Park, Seunghun Lee, Suil Jeon, Jungbin Lee, Seung‐Mo Hong, Sung Wook Hwang, Sang Hyoung Park, Dong‐Hoon Yang, Byong Duk Ye, Jeong‐Sik Byeon, Suk‐Kyun Yang, Jeong Hoon Lee, Do Hoon Kim, Ki Hean Kim, Seung‐Jae Myung
    Lasers in Surgery and Medicine.2023; 55(4): 378.     CrossRef
  • Application of artificial intelligence in diagnosis and treatment of colorectal cancer: A novel Prospect
    Zugang Yin, Chenhui Yao, Limin Zhang, Shaohua Qi
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Chicken skin mucosa surrounding small colorectal cancer could be an endoscopic predictive marker of submucosal invasion
    Ying-Jie Zhang, Wu Wen, Fan Li, Yi Jian, Chuan-Ming Zhang, Meng-Xia Yuan, Ye Yang, Feng-Lin Chen
    World Journal of Gastrointestinal Oncology.2023; 15(6): 1062.     CrossRef
  • A review on self-healing featured soft robotics
    Md. Ariful Islam, Labanya Talukder, Md. Firoj Al, Subrata K. Sarker, S. M. Muyeen, Prangon Das, Md. Mehedi Hasan, Sajal K. Das, Md. Manirul Islam, Md. Robiul Islam, Sumaya Ishrat Moyeen, Faisal R. Badal, Md. Hafiz Ahamed, Sarafat Hussain Abhi
    Frontiers in Robotics and AI.2023;[Epub]     CrossRef
  • Emergence of a New Optical Marker for Colorectal Neoplasms: To What Extent Should We Accept It?
    Han Hee Lee
    Clinical Endoscopy.2022; 55(2): 315.     CrossRef
  • Endoscopic diagnosis and treatment of early colorectal cancer
    Seung Wook Hong, Jeong-Sik Byeon
    Intestinal Research.2022; 20(3): 281.     CrossRef
  • Colonic Chicken Skin Mucosa Surrounding Colon Polyps Is an Endoscopic Predictive Marker for Colonic Neoplastic Polyps
    Yu Mi Lee, Kyung Ho Song, Hoon Sup Koo, Choong-Sik Lee, Inseok Ko, Sang Hyuk Lee, Kyu Chan Huh
    Gut and Liver.2022; 16(5): 754.     CrossRef
  • Artificial intelligence-based colorectal polyp histology prediction using narrow-band image-magnifying colonoscopy: a stepping stone for clinical practice
    Ji Young Chang
    Clinical Endoscopy.2022; 55(5): 699.     CrossRef
  • Response to Artificial intelligence-based colorectal polyp histology prediction using narrow-band image-magnifying colonoscopy: a stepping stone for clinical practice
    Istvan Racz, Andras Horvath, Zoltán Horvath
    Clinical Endoscopy.2022; 55(5): 701.     CrossRef
  • Photoacoustic endoscopy: A progress review
    Heng Guo, Ying Li, Weizhi Qi, Lei Xi
    Journal of Biophotonics.2020;[Epub]     CrossRef
  • Diagnostic efficacy of the Japan Narrow-band-imaging Expert Team and Pit pattern classifications for colorectal lesions: A meta-analysis
    Yu Zhang, Hui-Yan Chen, Xiao-Lu Zhou, Wen-Sheng Pan, Xin-Xin Zhou, Hang-Hai Pan
    World Journal of Gastroenterology.2020; 26(40): 6279.     CrossRef
  • 6,591 View
  • 115 Download
  • 11 Web of Science
  • 12 Crossref
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IBD
Immunohistochemical differentiation between chronic enteropathy associated with SLCO2A1 gene and other inflammatory bowel diseases
Satoko Yamaguchi, Shunichi Yanai, Shotaro Nakamura, Keisuke Kawasaki, Makoto Eizuka, Noriyuki Uesugi, Tamotsu Sugai, Junji Umeno, Motohiro Esaki, Takayuki Matsumoto
Intest Res 2018;16(3):393-399.   Published online July 27, 2018
DOI: https://doi.org/10.5217/ir.2018.16.3.393
AbstractAbstract PDFPubReaderePub
<b>Background/Aims</b><br/>

We recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) as causative variants of chronic enteropathy associated with SLCO2A1 (CEAS). The aim of this study was to evaluate SLCO2A1 protein expression in the intestinal tissues of patients with CEAS, intestinal Behçet's disease (BD), simple ulcer (SU), and Crohn's disease (CD).

Methods

Immunohistochemical staining using a polyclonal anti-SLCO2A1 antibody was performed on the resected intestinal specimens from 13 cases of CD, 9 cases of intestinal BD/SU, and 3 cases of CEAS. The extent of SLCO2A1 expression was determined by counting positively-staining vascular endothelial cells and scored as 0 (no cells), 1 (1%–30% cells), 2 (31%–60%), or 3 (>60%). The intensity of SLCO2A1 expression was scored either as 0 (negative), 1 (intermediate), or 2 (strong). The extent score and intensity score were summed for the final score of 0, 2, 3, 4, or 5.

Results

SLCO2A1 protein expression was observed in 1 of 3 cases of CEAS (33%), all 13 cases of CD (100%), and all 9 cases of BD/SU (100%). The mean final expression scores of CEAS, CD, and BD/SU were 1.6 (range, 0–5), 4.8 (range, 4–5), and 4.3 (range, 4–5), respectively. The final expression score in CEAS was significantly lower than in CD (P=0.03).

Conclusions

Immunohistochemical staining of the SLCO2A1 protein is considered useful to distinguish CEAS from other inflammatory bowel diseases.

Citations

Citations to this article as recorded by  
  • First case report of dichorionic diamniotic twins with chronic enteropathy associated with the SLCO2A1 gene
    Ryutaro Saura, Shin-ichiro Hagiwara, Keinosuke Hizuka, Nobuhiko Okamoto, Yuri Etani
    Clinical Journal of Gastroenterology.2024; 17(2): 240.     CrossRef
  • Characteristics of chronic enteropathy associated with SLCO2A1 gene (CEAS) in children, a unique type of monogenic very early-onset inflammatory bowel disease
    Jin Gyu Lim, Jae Sung Ko, Jung Min Ko, Hyun Young Kim, Man Jin Kim, Moon Woo Seong, Young Hun Choi, Gyeong Hoon Kang, Jaemoon Koh, Jin Soo Moon
    BMC Pediatrics.2024;[Epub]     CrossRef
  • Clinical and genetic characteristics of Chinese patients diagnosed with chronic enteropathy associated with SLCO2A1 gene
    Qing Shang, Yimin Dai, Jingyi Huang, Wei Liu, Weixun Zhou, Yaping Liu, Hong Yang, Qiang Wang, Yue Li
    Orphanet Journal of Rare Diseases.2024;[Epub]     CrossRef
  • Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children
    Paul Kelly, Kelley VanBuskirk, David Coomes, Samer Mouksassi, Gerald Smith, Zehra Jamil, Md Shabab Hossain, Sana Syed, Chelsea Marie, Phillip I Tarr, Peter B Sullivan, William A Petri, Donna M Denno, Tahmeed Ahmed, Mustafa Mahfuz, S Asad Ali, Sean R Moore
    The American Journal of Clinical Nutrition.2024; 120: S15.     CrossRef
  • Capsule Endoscopy for the Diagnosis of Suspected Small Bowel Bleeding
    P. P. Polyakov, A. Ya. Alimetov, A. V. Onopriev, A. V. Avakimyan, A. Kh. Kade, S. A. Zanin, E. S. Zanina, Z. S. Popov, A. I. Trofimenko, Z. T. Jndoyan, A. A. Avagimyan
    Innovative Medicine of Kuban.2023; (3): 121.     CrossRef
  • Attenuated Expression of SLCO2A1 Caused by DNA Methylation in Pediatric Inflammatory Bowel Disease
    Natsuki Ito, Takahiro Kudo, Hidetaka Eguchi, Keisuke Jimbo, Atsushi Furuhata, Toshiaki Okuno, Ichiro Takeuchi, Katsuhiro Arai, Takashi Ishige, Yasushi Okazaki, Toshiaki Shimizu
    Inflammatory Bowel Diseases.2023; 29(12): 1920.     CrossRef
  • Updates on the diagnosis and management of cryptogenic multifocal ulcerative stenosing enteropathy (CMUSE) and non-steroidal enteropathy
    Tom G. Moreels, Ayaskanta Singh
    Best Practice & Research Clinical Gastroenterology.2023; 64-65: 101847.     CrossRef
  • Chronic Enteropathy Associated with Solute Carrier Organic Anion Transporter Family, Member 2A1 (SLCO2A1) with Positive Immunohistochemistry for SLCO2A1 Protein
    Chizuru Ariake, Naoki Hosoe, Hinako Sakurai, Anna Tojo, Yukie Hayashi, Kenji JL Limpias Kamiya, Tomohisa Sujino, Kaoru Takabayashi, Kenjiro Kosaki, Satowa Seki, Tadakazu Hisamatsu, Haruhiko Ogata, Takanori Kanai
    Internal Medicine.2022; 61(17): 2607.     CrossRef
  • Epithelial Abnormalities in the Small Intestine of Zambian Children With Stunting
    Chola Mulenga, Sanja Sviben, Kanta Chandwe, Beatrice Amadi, Violet Kayamba, James A. J. Fitzpatrick, Victor Mudenda, Paul Kelly
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Functional analysis of mutant SLCO2A1 transporters found in patients with chronic enteropathy associated with SLCO2A1
    Satowa Seki, Gen Tanaka, Toru Kimura, Mari Hayashida, Jun Miyoshi, Minoru Matsuura, Hiroyuki Sakurai, Tadakazu Hisamatsu
    Journal of Gastroenterology and Hepatology.2022; 37(9): 1776.     CrossRef
  • Clinical and Genetic Characteristics of Korean Patients Diagnosed with Chronic Enteropathy Associated with SLCO2A1 Gene: A KASID Multicenter Study
    Hee Seung Hong, Jiwon Baek, Jae Chul Park, Ho-Su Lee, Dohoon Park, A-Ran Yoon, Soo Jung Park, Sung Noh Hong, Seong-Joon Koh, Chang Kyun Lee, Bo-In Lee, Sung Wook Hwang, Sang Hyoung Park, Seung-Jae Myung, Suk-Kyun Yang, Kyuyoung Song, Byong Duk Ye
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    Takeo Nakanishi, Yoshinobu Nakamura, Junji Umeno
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  • Meta-Analysis-Assisted Detection of Gravity-Sensitive Genes in Human Vascular Endothelial Cells
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    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • Chronic Nonspecific Multiple Ulcers of the Small Intestine / Chronic Enteropathy Associated with SLCO2A1 Gene (CEAS)
    Junji Umeno, Yuta Fuyuno, Yuichi Matsuno, Takehiro Torisu
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  • Retrospective study of the differential diagnosis between cryptogenic multifocal ulcerous stenosing enteritis and small bowel Crohn’s disease
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  • Chronic Enteropathy Associated with SLCO2A1 with Pachydermoperiostosis
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    Martin Keuchel, Niehls Kurniawan, Peter Baltes
    Current Opinion in Gastroenterology.2019; 35(3): 213.     CrossRef
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    Yuichi Matsuno, Junji Umeno, Motohiro Esaki, Yoichiro Hirakawa, Yuta Fuyuno, Yasuharu Okamoto, Atsushi Hirano, Shigeyoshi Yasukawa, Fumihito Hirai, Toshiyuki Matsui, Shuhei Hosomi, Kenji Watanabe, Naoki Hosoe, Haruhiko Ogata, Tadakazu Hisamatsu, Shunichi
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  • Distinction between Chronic Enteropathy Associated with the SLCO2A1 Gene and Crohn's Disease
    Shunichi Yanai, Satoko Yamaguchi, Shotaro Nakamura, Keisuke Kawasaki, Yosuke Toya, Noriyuki Yamada, Makoto Eizuka, Noriyuki Uesugi, Junji Umeno, Motohiro Esaki, Eiko Okimoto, Shunji Ishihara, Tamotsu Sugai, Takayuki Matsumoto
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  • Chronic enteropathy associated with SLCO2A1 gene: A case report and literature review
    Peng Hu, Huiqin He, Ning Dai, Shizheng Zhang, Liping Deng
    Clinics and Research in Hepatology and Gastroenterology.2019; 43(5): e68.     CrossRef
  • 6,925 View
  • 117 Download
  • 17 Web of Science
  • 20 Crossref
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