Background/Aims 5-Aminosalicylic acid (ASA) causes intolerance reactions in some patients. This study was performed to examine the prognosis of patients with ulcerative colitis (UC) and 5-ASA intolerance, and to evaluate the potential interaction between 5-ASA intolerance and the intestinal microbiota.
Methods We performed a retrospective cohort study of patients with UC who visited participating hospitals. The primary endpoint was to compare the incidence of hospitalization within 12 months between the 5-ASA intolerance group and the 5-ASA tolerance group. The secondary endpoint was to compare the risk of adverse clinical outcomes after the start of biologics between the 2 groups. We also assessed the correlation between 5-ASA intolerance and microbial change in an independently recruited cohort of patients with UC.
Results Of 793 patients, 59 (7.4%) were assigned to the 5-ASA intolerance group and 734 (92.5%) were assigned to the 5-ASA tolerance group. The admission rate and incidence of corticosteroid use were significantly higher in the intolerance than tolerance group (P< 0.001). In 108 patients undergoing treatment with anti-tumor necrosis factor biologics, 5-ASA intolerance increased the incidence of additional induction therapy after starting biologics (P< 0.001). The 5-ASA intolerance group had a greater abundance of bacteria in the genera Faecalibacterium, Streptococcus, and Clostridium than the 5-ASA tolerance group (P< 0.05).
Conclusions In patients with UC, 5-ASA intolerance is associated with a risk of adverse clinical outcomes and dysbiosis. Bacterial therapeutic optimization of 5-ASA administration may be important for improving the prognosis of patients with UC.
Citations
Citations to this article as recorded by
Hemp seed mitigates colonic inflammation through macrophage polarization and microbiota-barrier axis restoration Jieun Woo, Dekun Cheng, Erica A. Long, Kristin L. Whitney, Guangyi Shen, Lavanya Reddivari, Qing Jiang, Senay Simsek, Tingting Ju, Weicang Wang Food & Function.2026; 17(1): 231. CrossRef
Neural regulation of gut inflammation via autonomic nerves: therapeutic implications for inflammatory bowel disease Mai Hasegawa, Takaaki Kawaguchi, Hiroki Kiyohara, Toshiaki Teratani, Nobuhiro Nakamoto, Yohei Mikami, Takanori Kanai Immunological Medicine.2026; 49(2): 164. CrossRef
Evaluation of drug-induced lymphocyte stimulation test in mesalazine-associated allergic drug reaction Naoto Fukasawa, Hiroki Kiyohara, Takeya Adachi, Shinya Sugimoto, Yusuke Yoshimatsu, Soichiro Murakami, Ichiro Mizushima, Yuta Kaieda, Kaoru Takabayashi, Junya Tsunoda, Nobuhiro Nakamoto, Koichi Fukunaga, Masataka Taguri, Yohei Mikami, Takanori Kanai Journal of Allergy and Clinical Immunology: Global.2026; 5(2): 100625. CrossRef
5-Aminosalicylic Acid-Induced Colitis in a Patient with Rheumatoid Arthritis Without Inflammatory Bowel Disease: A Case Report Ryosuke Izumi, Issei Hirata, Yuta Hattori, Yuki Shirane, Hirosato Tamari, Teruo Mori, Makoto Higashiyama, Yoshio Kuga, Takashi Moriya Internal Medicine.2026;[Epub] CrossRef
Tacrolimus therapy for ulcerative colitis: a retrospective study of factors associated with inducing and maintaining remission Ayumi Ito, Shun Murasugi, Miki Koroku, Maria Yonezawa, Teppei Omori, Shinichi Nakamura, Katsutoshi Tokushige, Yousuke Nakai BMC Gastroenterology.2026;[Epub] CrossRef
Association of Proton Pump Inhibitor and Potassium‐Competitive Acid Blocker Use With Discontinuation and Intolerance of Oral 5‐Aminosalicylic Acid in Patients With Ulcerative Colitis Shinsuke Otagiri, Takahiro Ito, Keiji Yagisawa, Ayumu Sugitani, Atsuo Maemoto JGH Open.2026;[Epub] CrossRef
The Gut-Brain Axis in Comorbidity of Inflammatory Bowel Disease and Anxiety/Depression: Mechanisms, Controversies, and Future Directions Yuheng Cui, Yangfeng Huang International Journal of General Medicine.2026; Volume 19: 1. CrossRef
Comment on “Association of Proton Pump Inhibitor and Potassium‐Competitive Acid Blocker Use With Discontinuation and Intolerance of Oral 5‐Aminosalicylic Acid in Patients With Ulcerative Colitis” Bashair Fatima Journal of Gastroenterology and Hepatology.2026;[Epub] CrossRef
Gut Microbiome Dysbiosis and Inflammatory Bowel Disease Complement Each Other Huan Zhang, Jingrong Xiang, Jie Feng, Mengting Zhang, Qinhua Xi Digestive Diseases.2025; 43(3): 345. CrossRef
Inactivated Cells and Metabolites of Saccharomyces boulardii Alleviate Inflammation Damage in Caco-2 Monolayer Cells and Mice with Ulcerative Colitis Yuxin Jin, Zehui Niu, Menglin Feng, Huilian Che, Zhihong Liang Antioxidants.2025; 14(6): 737. CrossRef
Increasing age at diagnosis raises malignancy risk and aminosalicylate intolerance influences therapeutic strategies in ulcerative colitis: a multicenter I‑BRITE cohort study Shintaro Akiyama, Yuka Ito, Mamiko Shiroyama, Satoshi Suzuki, Masanori Ochi, Toshiro Kamoshida, Hiroshi Kashimura, Junichi Iwamoto, Rie Saito, Tsuyoshi Kaneko, Kazuto Ikezawa, Yoshinori Hiroshima, Junji Hattori, Takashi Mamiya, Satoshi Fukuda, Kazuho Iked Journal of Gastroenterology.2025; 60(10): 1259. CrossRef
Gut microbial healing in IBD: visionary approach or evidence-based reality? Linda Nanni, Marco Murgiano, Chieh-En Hsu, Sheida Khalili, Giovanni Cammarota, Alfredo Papa, Antonio Gasbarrini, Franco Scaldaferri, Loris Riccardo Lopetuso Expert Review of Gastroenterology & Hepatology.2025; 19(8): 833. CrossRef
Effectiveness of granulocyte and monocyte adsorptive apheresis in patients with ulcerative colitis and 5-aminosalicylate intolerance Masaki Kato, Masaki Yamashita, Shigeki Kojima, Mitsuto Tsukui, Yoshihiko Iijima, Kenichi Araki, Jun Ishida, Takumi Komatsu, Yusuke Nakamoto, Akiyo Kawashima, Maki Konno, Hirofumi Kiyokawa, Yoshinori Sato, Tsutomu Sakurada, Tadateru Maehata, Hiroshi Yasuda Medicine.2025; 104(31): e43389. CrossRef
Significance of the drug-induced lymphocyte stimulation test for various oral mesalamines in ulcerative colitis with mesalamine intolerance Akira Madarame, Masakatsu Fukuzawa, Kumiko Uchida, Tadashi Ichimiya, Sakiko Naito, Yoshiya Yamauchi, Takashi Morise, Yasuyuki Kagawa, Takahiro Muramatsu, Takao Itoi, Mohammed Misbah Ul Haq PLOS One.2025; 20(10): e0334969. CrossRef
Lacticaseibacillus rhamnosus MS27 Potentially Prevents Ulcerative Colitis Through Modulation of Gut Microbiota Jie Zhang, Jiakun Shen, Linbao Ji, Peng Tan, Chunchen Liu, Xiujun Zhang, Xi Ma International Journal of Molecular Sciences.2025; 26(23): 11397. CrossRef
Efficacy of 5-aminosalicylic acid continuation versus discontinuation in patients with ulcerative colitis escalated to advanced therapy: a systematic review and meta-analysis of adjusted effect estimates Hyun Hee Sul, Douglas Mesadri Gewehr, Hara Kang, Odery Ramos, Ryan C Ungaro, Charles N Bernstein Journal of Crohn's and Colitis.2025;[Epub] CrossRef
Drug-induced Interstitial Nephritis in a Patient with Ulcerative Colitis Treated with 5-Aminosalicylic Acid Daichi Hayashi, Tsutomu Nishida, Naoto Osugi, Yasuo Kusunoki, Satoru Okabe, Yoshifumi Fujii, Dai Nakamatsu, Kengo Matsumoto, Masashi Yamamoto, Koji Fukui Internal Medicine.2024; 63(8): 1081. CrossRef
The impact of 5-aminosalicylates on the efficacy of mesenchymal stem cell therapy in a murine model of ulcerative colitis Huanhuan Chen, Huimin Wang, XiaoJing Xu, Ya'nan Hu, Jing Su, Dongdong Li, Zimu Li, Shixiang Feng, Jinming Liu, Huanxiang Zhang, Xiaoyan Wang International Immunopharmacology.2024; 134: 112255. CrossRef
CURRENT STATUS, PROBLEMS AND PROSPECTS OF ULCERATIVE COLITIS MEDICAL CORRECTION (LITERATURE REVIEW) T. O. Briukhanova, O. A. Nakonechna, O. V Babenko Bulletin of Problems Biology and Medicine.2023; 1(3): 28. CrossRef
Significance of 5-Aminosalicylic Acid Intolerance in the Clinical Management of Ulcerative Colitis Yohei Mikami, Junya Tsunoda, Shohei Suzuki, Ichiro Mizushima, Hiroki Kiyohara, Takanori Kanai Digestion.2023; 104(1): 58. CrossRef
Genetic Background of Mesalamine-induced Fever and Diarrhea in Japanese Patients with Inflammatory Bowel Disease Kaoru Suzuki, Yoichi Kakuta, Takeo Naito, Tetsuya Takagawa, Hiroyuki Hanai, Hiroshi Araki, Yu Sasaki, Hirotake Sakuraba, Makoto Sasaki, Tadakazu Hisamatsu, Satoshi Motoya, Takayuki Matsumoto, Motoyuki Onodera, Yoh Ishiguro, Hiroshi Nakase, Akira Andoh, Sa Inflammatory Bowel Diseases.2022; 28(1): 21. CrossRef
Classification and clinical features of adverse drug reactions in patients with ulcerative colitis treated with 5‐aminosalicylate acid: a single-center, observational study Yuri Tsujii, Tsutomu Nishida, Naoto Osugi, Yoshifumi Fujii, Aya Sugimoto, Dai Nakamatsu, Kaori Mukai, Kengo Matsumoto, Shiro Hayashi, Masashi Yamamoto, Sachiko Nakajima Scandinavian Journal of Gastroenterology.2022; 57(2): 190. CrossRef
The Prognostic Value of Residual Nonrectal Inflammation in Ulcerative Colitis Eun Ae Kang Gut and Liver.2022; 16(3): 487. CrossRef
Personalized medicine in inflammatory bowel disease: Perspectives on Asia Su Hyun Park, Sang Hyoung Park Journal of Gastroenterology and Hepatology.2022; 37(8): 1434. CrossRef
Updates on conventional therapies for inflammatory bowel diseases: 5-aminosalicylates, corticosteroids, immunomodulators, and anti-TNF-α Jihye Park, Jae Hee Cheon The Korean Journal of Internal Medicine.2022; 37(5): 895. CrossRef
The emerging microbiome‐based approaches to IBD therapy: From SCFAs to urolithin A Mohammad Rudiansyah, Saade Abdalkareem Jasim, Bakhadir S. Azizov, Vadim Samusenkov, Walid Kamal Abdelbasset, Ghulam Yasin, Hawraa Jabbar Mohammad, Mohammed Abed Jawad, Trias Mahmudiono, Seyed Reza Hosseini‐Fard, Rasoul Mirzaei, Sajad Karampoor Journal of Digestive Diseases.2022; 23(8-9): 412. CrossRef
Multicenter survey on mesalamine intolerance in patients with ulcerative colitis Sakiko Hiraoka, Akiko Fujiwara, Tatsuya Toyokawa, Reiji Higashi, Yuki Moritou, Shinjiro Takagi, Kazuhiro Matsueda, Seiyuu Suzuki, Jiro Miyaike, Toshihiro Inokuchi, Masahiro Takahara, Jun Kato, Hiroyuki Okada Journal of Gastroenterology and Hepatology.2021; 36(1): 137. CrossRef
Bacteriotherapy for inflammatory bowel disease Yusuke Yoshimatsu, Yohei Mikami, Takanori Kanai Inflammation and Regeneration.2021;[Epub] CrossRef
Treatment of inflammatory bowel diseases: focusing on 5-aminosalicylates and immunomodulators You Sun Kim Journal of the Korean Medical Association.2021; 64(9): 596. CrossRef
The Communication Between Intestinal Microbiota and Ulcerative Colitis: An Exploration of Pathogenesis, Animal Models, and Potential Therapeutic Strategies Yu Hu, Zhen Ye, Mingquan Wu, Yingqi She, Linzhen Li, Yujie Xu, Kaihua Qin, Zhipeng Hu, Maoyi Yang, Fating Lu, Qiaobo Ye Frontiers in Medicine.2021;[Epub] CrossRef
Pharmacogenetics-based personalized treatment in patients with inflammatory bowel disease: A review Ji Young Chang, Jae Hee Cheon Precision and Future Medicine.2021; 5(4): 151. CrossRef
5‐aminosalicylate–intolerant patients are at increased risk of colectomy for ulcerative colitis Shuji Hibiya, Yusuke Matsuyama, Toshimitsu Fujii, Chiaki Maeyashiki, Eiko Saito, Kimiko Ito, Hiromichi Shimizu, Ami Kawamoto, Maiko Motobayashi, Kento Takenaka, Masakazu Nagahori, Masayuki Kurosaki, Tsunehito Yauchi, Kazuo Ohtsuka, Takeo Fujiwara, Ryuichi Alimentary Pharmacology & Therapeutics.2021; 53(1): 103. CrossRef
Mesalazine allergy and an attempt at desensitization therapy in patients with inflammatory bowel disease Satohiro Matsumoto, Hirosato Mashima Scientific Reports.2020;[Epub] CrossRef
Ulcerative colitis (UC) is a chronic inflammatory condition of the gastrointestinal tract. Although the cause of UC is postulated to be multifactorial in nature, including genetic predisposition, epithelial barrier defects, dysregulation of immune responses, and environmental factors, the specific pathogenesis of UC is still incompletely understood. In the treatment of UC so far, a method of suppressing immunity and treating it has been mainstream. Immunosuppressant drugs, including thiopurines (azathioprine or 6-mercaptopurine), anti-tumor necrosis factor-α (anti-TNF-α) antibody (infliximab and adalimumab), and calcineurin inhibitor, can be used in treat patients with corticosteroid-dependent and/or corticosteroid-refractory moderateto- severe UC. Recently, in addition to such a conventional therapeutic agent, golimumab, which is the first transgenic human monoclonal anti-TNF-α antibody to be fabricated, anti α-4/β-7 integrin antibody, and Janus kinase inhibitor have been reported to novel immunosuppressant therapy. Furthermore, other treatments with unique mechanisms different from immunosuppression, have also been suggested, including fecal microbiota transplantation and Indigo naturalis, which is a Chinese herbal medicine. We compared the features and efficacy of these new treatments. In this issue, the features and treatment options for these new treatments is reviewed.
Citations
Citations to this article as recorded by
Squid cartilage-derived chondroitin sulfate from Uroteuthis chinensis: a novel marine prebiotic modulating gut microbiota and ameliorating ulcerative colitis Shiwei Chen, Hanjing Li, Rongkun Chen, Zihua Liang, Zongjie Ou, Pengzhe Zhang, Li Ni, Jiacong Deng, Xucong Lv Food Research International.2026; 235: 119141. CrossRef
Systemic investigation of the mechanism underlying the therapeutic effect of Astragalus membranaceus in ulcerative colitis Jingxin Mao, Lihong Tan, Cheng Tian, Wenxiang Wang, YanLin Zou, Zhaojing Zhu, Yan Li The American Journal of the Medical Sciences.2025; 369(2): 238. CrossRef
Hepatoprotective Effects of Resveratrol on Acetaminophen-Induced Acute Liver Injury and Its Implications for Tofacitinib Disposition in Rats Hyeon Gyeom Choi, So Yeon Park, Sung Hun Bae, Sun-Young Chang, So Hee Kim Biomolecules & Therapeutics.2025; 33(3): 501. CrossRef
Evaluation of Indigo Naturalis Prepared Using a Novel Method: Therapeutic Effects on Experimental Ulcerative Colitis in Mice Xianxiang Xu, Lin Lin, Wenjie Ning, Xinyi Zhou, Aftab Ullah, Huiyong Yang, Xunxun Wu, Yong Diao Pharmaceutics.2025; 17(5): 674. CrossRef
Physiologically Based Pharmacokinetic Simulation of Tofacitinib in Humans Using Extrapolation from Single-Species Renal Failure Model Sung Hun Bae, So Yeon Park, Hyeon Gyeom Choi, So Hee Kim Pharmaceutics.2025; 17(7): 914. CrossRef
Modulation of tofacitinib pharmacokinetics by isosakuranetin in streptozotocin-induced diabetic rats Hyeon Gyeom Choi, Sung Hun Bae, So Yeon Park, Hyoungsu Kim, Sun-Young Chang, So Hee Kim Journal of Pharmaceutical Investigation.2025;[Epub] CrossRef
Development of Validated RP-UHPLC and Analogous UV Spectroscopic Methods for the Analysis of Tofacitinib Citrate Jahid Hossain, Diponkor Kumar Shill, Kausik Chandra Mondal, Abu Shara Shamsur Rouf, Uttom Kumar Drug Analytical Research.2025; 9(2): 48. CrossRef
Histologic features and predicting prognosis in ulcerative colitis patients with mild endoscopic activity Seung Yong Shin, Hee Sung Kim, Kisung Kim, Chang Won Choi, Jung Min Moon, Jeong Wook Kim, Hyun Jin Joo, Jeongkuk Seo, Muhyeon Sung, Chang Hwan Choi The Korean Journal of Internal Medicine.2024; 39(1): 68. CrossRef
Recent Updates on the Therapeutics Benefits, Clinical Trials, and Novel
Delivery Systems of Chlorogenic Acid for the Management of Diseases with a
Special Emphasis on Ulcerative Colitis Ranjit K. Harwansh, Hemant Bhati, Rohitas Deshmukh Current Pharmaceutical Design.2024; 30(6): 420. CrossRef
Dose-dependent effects of cobalt chloride supplementation in a rat model of acetic acid-induced ulcerative colitis Akinleye Stephen Akinrinde, Ekundayo Stephen Samuel, Bisi Olajumoke Adeoye Comparative Clinical Pathology.2024; 33(5): 705. CrossRef
Pharmacogenetics in personalized treatment in pediatric patients with inflammatory bowel disease (IBD) Daniela Kosorínová, Pavlína Suchá, Zuzana Havlíčeková, Marek Pršo, Pavol Dvoran, Peter Bánovčin Česko-slovenská pediatrie.2024; 79(4): 213. CrossRef
Long‐term safety and efficacy of filgotinib for the treatment of moderately to severely active ulcerative colitis: Interim analysis from up to 4 years of follow‐up in the SELECTION open‐label long‐term extension study Brian G. Feagan, Katsuyoshi Matsuoka, Gerhard Rogler, David Laharie, Séverine Vermeire, Silvio Danese, Edward V. Loftus, Ian Beales, Stefan Schreiber, Hyo Jong Kim, Margaux Faes, Angela de Haas, Tomasz Masior, Christine Rudolph, Laurent Peyrin‐Biroulet Alimentary Pharmacology & Therapeutics.2024; 60(5): 563. CrossRef
Loganin Ameliorates Acute Kidney Injury and Restores Tofacitinib Metabolism in Rats: Implications for Renal Protection and Drug Interaction Hyeon Gyeom Choi, So Yeon Park, Sung Hun Bae, Sun-Young Chang, So Hee Kim Biomolecules & Therapeutics.2024; 32(5): 601. CrossRef
Dynamic changes in the gut microbiota composition during adalimumab therapy in patients with ulcerative colitis: implications for treatment response prediction and therapeutic targets Han Na Oh, Seung Yong Shin, Jong-Hwa Kim, Jihye Baek, Hyo Jong Kim, Kang-Moon Lee, Soo Jung Park, Seok-Young Kim, Hyung-Kyoon Choi, Wonyong Kim, Woo Jun Sul, Chang Hwan Choi Gut Pathogens.2024;[Epub] CrossRef
Protective effect of (E)-(2,4-dihydroxy)-α-aminocinnamic acid, a hydroxy cinnamic acid derivative, in an ulcerative colitis model induced by TNBS Astrid Mayleth Rivera Antonio, Itzia Irene Padilla Martínez, Yazmín Karina Márquez-Flores, Alan Hipólito Juárez Solano, Mónica A. Torres Ramos, Martha Cecilia Rosales Hernández Bioscience Reports.2024;[Epub] CrossRef
Lactiplantibacillus plantarum BW2013 protects mucosal integrity and modulates gut microbiota of mice with colitis Xiaohui Niu, Qian Li, Na Luan, Jia Liu, Michael Zhang, Jun An, Zuming Li, Zhihui Bai, Ran Xia, Zhichao Wu Canadian Journal of Microbiology.2023; 69(4): 158. CrossRef
Reviewing not Homer’s Iliad, but “Kai Bao Ben Cao”: indigo dye—the past, present, and future Yusuke Yoshimatsu, Tomohisa Sujino, Takanori Kanai Intestinal Research.2023; 21(2): 174. CrossRef
Effect and mechanism of total ginsenosides repairing SDS‑induced Drosophila enteritis model based on MAPK pathway Hang Su, Yujing Tan, Zhijiang Zhou, Chunjuan Wang, Wei Chen, Jinlong Wang, Haiming Sun Experimental and Therapeutic Medicine.2023;[Epub] CrossRef
Effects of Hyperlipidemia on the Pharmacokinetics of Tofacitinib, a JAK 1/3 Inhibitor, in Rats Jong Mun Won, Hyeon Gyeom Choi, So Yeon Park, Jang-Hee Kim, So Hee Kim Pharmaceutics.2023; 15(9): 2195. CrossRef
Knowledge, attitude, and practice of patients living with inflammatory bowel disease: A cross-sectional study Xiao-Xiao Shao, Lu-Yan Fang, Xu-Ri Guo, Wei-Zhong Wang, Rui-Xin Shi, Dao-Po Lin World Journal of Gastroenterology.2023; 29(43): 5818. CrossRef
Biomarker dynamics during infliximab salvage for acute severe ulcerative colitis: C-reactive protein (CRP)-lymphocyte ratio and CRP-albumin ratio are useful in predicting colectomy Danny Con, Bridgette Andrew, Steven Nicolaides, Daniel R van Langenberg, Abhinav Vasudevan Intestinal Research.2022; 20(1): 101. CrossRef
Efficacy of sigmoidoscopy for evaluating disease activity in patients with ulcerative colitis Su Bum Park, Seong-Jung Kim, Jun Lee, Yoo Jin Lee, Dong Hoon Baek, Geom Seog Seo, Eun Soo Kim, Sang-Wook Kim, So Yeong Kim BMC Gastroenterology.2022;[Epub] CrossRef
Protective effects of Ligularia fischeri root extracts against ulcerative colitis in mice through activation of Bcl-2/Bax signalings Yong-Ping Fu, Huan Yuan, Yan Xu, Ru-Ming Liu, Yi Luo, Jian-Hui Xiao Phytomedicine.2022; 99: 154006. CrossRef
Traditional Chinese Medicine Alleviates Ulcerative Colitis via Modulating Gut Microbiota Wan Feng, Lei Zhu, Hong Shen, Jin-Yi Wan Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1. CrossRef
Risk of Hepatitis B Virus (HBV) Reactivation in Patients with Immune-Mediated Inflammatory Diseases Receiving Biologics: Focus on the Timing of Biologics after Anti-HBV Treatment Soo Min Ahn, Jonggi Choi, Byong Duk Ye, Suk-Kyun Yang, Ji Seon Oh, Yong‑Gil Kim, Chang-Keun Lee, Bin Yoo, Sang Hyoung Park, Seokchan Hong Gut and Liver.2022; 16(4): 567. CrossRef
Oral beclomethasone dipropionate as an add-on therapy and response prediction in Korean patients with ulcerative colitis Kyuwon Kim, Hee Seung Hong, Kyunghwan Oh, Jae Yong Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye, Sang Hyoung Park The Korean Journal of Internal Medicine.2022; 37(6): 1140. CrossRef
“Two-birds-one-stone” colon-targeted nanomedicine treats ulcerative colitis via remodeling immune microenvironment and anti-fibrosis Jiaxin Zhang, Ante Ou, Xueping Tang, Rong Wang, Yujuan Fan, Yuefei Fang, Yuge Zhao, Pengfei Zhao, Dongying Chen, Bing Wang, Yongzhuo Huang Journal of Nanobiotechnology.2022;[Epub] CrossRef
Additive effect of probiotics (Mutaflor) on 5-aminosalicylic acid therapy in patients with ulcerative colitis Soo-Kyung Park, Sang-Bum Kang, SangSoo Kim, Tae Oh Kim, Jae Myung Cha, Jong Pil Im, Chang Hwan Choi, Eun Soo Kim, Geom Seog Seo, Chang Soo Eun, Dong Soo Han, Dong Il Park The Korean Journal of Internal Medicine.2022; 37(5): 949. CrossRef
Effects of Dextran Sulfate Sodium-Induced Ulcerative Colitis on the Disposition of Tofacitinib in Rats Sung Hun Bae, Hyo Sung Kim, Hyeon Gyeom Choi, Sun-Young Chang, So Hee Kim Biomolecules & Therapeutics.2022; 30(6): 510. CrossRef
Effects of Isosakuranetin on Pharmacokinetic Changes of Tofacitinib in Rats with N-Dimethylnitrosamine-Induced Liver Cirrhosis Sung Hun Bae, Hyeon Gyeom Choi, So Yeon Park, Sun-Young Chang, Hyoungsu Kim, So Hee Kim Pharmaceutics.2022; 14(12): 2684. CrossRef
Trends in Corticosteroid Prescriptions for Ulcerative Colitis and Factors Associated with Long-Term Corticosteroid Use: Analysis Using Japanese Claims Data from 2006 to 2016 Katsuyoshi Matsuoka, Ataru Igarashi, Noriko Sato, Yuri Isono, Maki Gouda, Katsuhiko Iwasaki, Ayako Shoji, Tadakazu Hisamatsu Journal of Crohn's and Colitis.2021; 15(3): 358. CrossRef
Comparison of Long-Term Outcomes of Infliximab versus Adalimumab Treatment in Biologic-Naïve Patients with Ulcerative Colitis Yong Il Lee, Yehyun Park, Soo Jung Park, Tae Il Kim, Won Ho Kim, Jae Hee Cheon Gut and Liver.2021; 15(2): 232. CrossRef
Efficacy and Safety of Fecal Microbiota Transplantation and Prospect of Microbe-based Therapies for Inflammatory Bowel Disease Hoon Gil Jo, Geom Seog Seo The Korean Journal of Gastroenterology.2021; 78(1): 31. CrossRef
The Clinical Features of Inflammatory Bowel Disease in Patients with Obesity Seong Kyun Kim, Ho-Su Lee, Beom-Jun Kim, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park, Masanao Nakamura Canadian Journal of Gastroenterology and Hepatology.2021;[Epub] CrossRef
Treatment of inflammatory bowel diseases: focusing on 5-aminosalicylates and immunomodulators You Sun Kim Journal of the Korean Medical Association.2021; 64(9): 596. CrossRef
Long-term Outcomes after the Discontinuation of Anti-Tumor Necrosis Factor-α Therapy in Patients with Inflammatory Bowel Disease under Clinical Remission: A Korean Association for the Study of Intestinal Disease Multicenter Study Joo Hye Song, Eun Ae Kang, Soo-Kyung Park, Sung Noh Hong, You Sun Kim, Ki Bae Bang, Kyeong Ok Kim, Hong Sub Lee, Sang-Bum Kang, Seung Yong Shin, Eun Mi Song, Jong Pil Im, Chang Hwan Choi Gut and Liver.2021; 15(5): 752. CrossRef
Treatment of inflammatory bowel diseases: focusing on biologic agents and new therapies Hyo Yeop Song, Geom Seog Seo Journal of the Korean Medical Association.2021; 64(9): 605. CrossRef
Current status of inflammatory bowel diseases in Korea Suk-Kyun Yang Journal of the Korean Medical Association.2021; 64(9): 572. CrossRef
Intestinal microbiota and inflammatory bowel diseases Chang Soo Eun Journal of the Korean Medical Association.2021; 64(9): 588. CrossRef
Does cytomegalovirus load predict the outcome of acute severe ulcerative colitis? You Sun Kim Intestinal Research.2021; 19(4): 357. CrossRef
Clinical Course of COVID-19 in Patients with Inflammatory Bowel Disease in Korea: a KASID Multicenter Study Jin Wook Lee, Eun Mi Song, Sung-Ae Jung, Sung Hoon Jung, Kwang Woo Kim, Seong-Joon Koh, Hyun Jung Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park Journal of Korean Medical Science.2021;[Epub] CrossRef
Development of a Machine Learning Model to Distinguish between Ulcerative Colitis and Crohn’s Disease Using RNA Sequencing Data Soo-Kyung Park, Sangsoo Kim, Gi-Young Lee, Sung-Yoon Kim, Wan Kim, Chil-Woo Lee, Jong-Lyul Park, Chang-Hwan Choi, Sang-Bum Kang, Tae-Oh Kim, Ki-Bae Bang, Jaeyoung Chun, Jae-Myung Cha, Jong-Pil Im, Kwang-Sung Ahn, Seon-Young Kim, Dong-Il Park Diagnostics.2021; 11(12): 2365. CrossRef
Pharmacogenetics-based personalized treatment in patients with inflammatory bowel disease: A review Ji Young Chang, Jae Hee Cheon Precision and Future Medicine.2021; 5(4): 151. CrossRef
Intestinal Epithelial Deletion of Sphk1 Prevents Colitis-Associated Cancer Development by Inhibition of Epithelial STAT3 Activation Seung Bin Park, Byung-il Choi, Beom Jae Lee, Nam Joo Kim, Yoon A. Jeong, Moon Kyung Joo, Hyo Jung Kim, Jong-Jae Park, Jae Seon Kim, Yoon-Seok Noh, Hyun Joo Lee Digestive Diseases and Sciences.2020; 65(8): 2284. CrossRef
Simple determination and quantification of tofacitinib, a JAK inhibitor, in rat plasma, urine and tissue homogenates by HPLC and its application to a pharmacokinetic study Ji Eun Kim, Mun Young Park, So Hee Kim Journal of Pharmaceutical Investigation.2020; 50(6): 603. CrossRef
Effects of Diabetes Mellitus on the Disposition of Tofacitinib, a Janus Kinase Inhibitor, in Rats Eun Hye Gwak, Hee Young Yoo, So Hee Kim Biomolecules & Therapeutics.2020; 28(4): 361. CrossRef
Slower Elimination of Tofacitinib in Acute Renal Failure Rat Models: Contribution of Hepatic Metabolism and Renal Excretion Sung Hun Bae, Sun-Young Chang, So Hee Kim Pharmaceutics.2020; 12(8): 714. CrossRef
The amelioration of ulcerative colitis induced by Dinitrobenzenesulfonic acid with Radix Hedysari Gengen Shi, Donghan Wang, Zhiyuan Xue, Xianglin Zhou, Yaoyao Fang, Shilan Feng, Lianggong Zhao Journal of Food Biochemistry.2020;[Epub] CrossRef
Dose-Dependent Pharmacokinetics of Tofacitinib in Rats: Influence of Hepatic and Intestinal First-Pass Metabolism Ji Sang Lee, So Hee Kim Pharmaceutics.2019; 11(7): 318. CrossRef
Dermatologische Komplikationen unter Therapie mit Biologika bei entzündlichen Autoimmunerkrankungen Wiebke Sondermann, Saskia Herz, Elsa Sody, Andreas Körber JDDG: Journal der Deutschen Dermatologischen Gesellschaft.2019; 17(10): 1029. CrossRef
Dermatological complications of therapy with biologics in inflammatory autoimmune diseases Wiebke Sondermann, Saskia Herz, Elsa Sody, Andreas Körber JDDG: Journal der Deutschen Dermatologischen Gesellschaft.2019; 17(10): 1029. CrossRef